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https://www.readbyqxmd.com/read/29135773/tree-based-claims-algorithm-for-measuring-pretreatment-quality-of-care-in-medicare-disabled-hepatitis-c-patients
#1
Viktor V Chirikov, Fadia T Shaya, Ebere Onukwugha, C Daniel Mullins, Susan dosReis, Charles D Howell
BACKGROUND: To help broaden the use of machine-learning approaches in health services research, we provide an easy-to-follow framework on the implementation of random forests and apply it to identify quality of care (QC) patterns correlated with treatment receipt among Medicare disabled patients with hepatitis C virus (HCV). METHODS: Using Medicare claims 2006-2009, we identified 1936 patients with 6 months continuous enrollment before HCV diagnosis. We ran a random forest on 14 pretreatment QC indicators, extracted the forest's representative tree, and aggregated its terminal nodes into 4 QC groups predictive of treatment...
December 2017: Medical Care
https://www.readbyqxmd.com/read/29134483/evaluating-the-impact-of-dyslexia-laws-on-the-identification-of-specific-learning-disability-and-dyslexia
#2
B Anne Barber Phillips, Timothy N Odegard
Dyslexia is a specific learning disability that impacts word reading accuracy and/or reading fluency. Over half of the states in the USA have passed legislation intended to promote better identification of individuals with dyslexia. To date, no study has been conducted to investigate the potential impact of state laws on the identification of specific learning disability (SLD), and limited data has been presented on the rate at which students in public school settings are identified with dyslexia. The first aim of the current study was to determine if any detectable changes in the identification rates of SLD have occurred in states implementing dyslexia laws because most states do not report number of students identified as dyslexic but rather those students identified with an SLD...
November 13, 2017: Annals of Dyslexia
https://www.readbyqxmd.com/read/29133437/abnormal-microglia-and-enhanced-inflammation-related-gene-transcription-in-mice-with-conditional-deletion-of-ctcf-in-camk2a-cre-expressing-neurons
#3
Bryan E McGill, Ruteja A Barve, Susan E Maloney, Amy Strickland, Nicholas Rensing, Peter Wang, Michael Wong, Richard Head, David F Wozniak, Jeffrey Milbrandt
CCCTC-binding factor (CTCF) is an 11 zinc finger DNA-binding domain protein that regulates gene expression by modifying three dimensional chromatin structure. Human mutations in CTCF cause intellectual disability and autistic features. Knocking out Ctcf in mouse embryonic neurons is lethal by neonatal age, but the effects of CTCF deficiency in postnatal neurons are less well studied. We knocked out Ctcf postnatally in glutamatergic forebrain neurons under the control of Camk2a-CreCtcf(loxP/loxP) ;Camk2a-Cre+ (Ctcf CKO) mice of both sexes were viable and exhibited profound deficits in spatial learning/memory, impaired motor co-ordination, and decreased sociability by 4 months of age...
November 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29128904/pharmacological-rescue-of-hippocampal-fear-learning-deficits-in-fragile-x-syndrome
#4
Luis A Martinez, Maria Victoria Tejada-Simon
Fragile X Syndrome (FXS) is the leading cause of autism spectrum disorder and intellectual disability and results from loss of Fragile X mental retardation protein (FMRP). In neurons, FMRP controls the translation of synaptic plasticity proteins that are implicated in learning and memory. FMRP also regulates development- and experience-dependent actin cytoskeleton remodeling within dendritic spines through the small Rho GTPase Rac1. Modulation of Rac1 activity is critical during synaptic plasticity as well as learning and memory...
November 11, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29128445/the-promise-of-induced-pluripotent-stem-cells-for-neurodevelopmental-disorders
#5
REVIEW
Katrin Linda, Carol Fiuza, Nael Nadif Kasri
A major challenge in clinical genetics and medicine is represented by genetically and phenotypically highly diverse neurodevelopmental disorders, like for example intellectual disability and autism. Intellectual disability is characterized by substantial limitations in cognitive function and adaptive behaviour. At the cellular level, this is reflected by deficits in synaptic structure and plasticity and therefore has been coined as a synaptic disorder or "synaptopathy". In this review, we summarize the findings from recent studies in which iPSCs have been used to model specific neurodevelopmental syndromes, including Fragile X syndrome, Rett syndrome, Williams-Beuren syndrome and Phelan-McDermid syndrome...
November 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29122542/twin-twin-transfusion-syndrome-what-we-have-learned-from-clinical-trials
#6
REVIEW
Fatiha Djaafri, Julien Stirnemann, Imen Mediouni, Claire Colmant, Yves Ville
Monochorionic twin pregnancies are at increased risk for adverse outcome compared to dichorionic twin pregnancies and singletons. Monochorionic-specific complications include twin-twin transfusion syndrome (TTTS), twin anemia-polycythemia sequence, single intrauterine fetal demise and its consequences on the co-twin, and selective intrauterine growth restriction. Whereas the natural history of monochorionic-specific complications carries a high risk of fetal death or severe neurologic disability, a framework now exists, based on well-designed clinical trials, for optimal treatment of these entities...
November 6, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29118725/cognitive-and-neural-correlates-of-mathematical-giftedness-in-adults-and-children-a-review
#7
REVIEW
Timothy Myers, Emma Carey, Dénes Szűcs
Most mathematical cognition research has focused on understanding normal adult function and child development as well as mildly and moderately impaired mathematical skill, often labeled developmental dyscalculia and/or mathematical learning disability. In contrast, much less research is available on cognitive and neural correlates of gifted/excellent mathematical knowledge in adults and children. In order to facilitate further inquiry into this area, here we review 40 available studies, which examine the cognitive and neural basis of gifted mathematics...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29110728/how-a-diverse-research-ecosystem-has-generated-new-rehabilitation-technologies-review-of-nidilrr-s-rehabilitation-engineering-research-centers
#8
REVIEW
David J Reinkensmeyer, Sarah Blackstone, Cathy Bodine, John Brabyn, David Brienza, Kevin Caves, Frank DeRuyter, Edmund Durfee, Stefania Fatone, Geoff Fernie, Steven Gard, Patricia Karg, Todd A Kuiken, Gerald F Harris, Mike Jones, Yue Li, Jordana Maisel, Michael McCue, Michelle A Meade, Helena Mitchell, Tracy L Mitzner, James L Patton, Philip S Requejo, James H Rimmer, Wendy A Rogers, W Zev Rymer, Jon A Sanford, Lawrence Schneider, Levin Sliker, Stephen Sprigle, Aaron Steinfeld, Edward Steinfeld, Gregg Vanderheiden, Carolee Winstein, Li-Qun Zhang, Thomas Corfman
Over 50 million United States citizens (1 in 6 people in the US) have a developmental, acquired, or degenerative disability. The average US citizen can expect to live 20% of his or her life with a disability. Rehabilitation technologies play a major role in improving the quality of life for people with a disability, yet widespread and highly challenging needs remain. Within the US, a major effort aimed at the creation and evaluation of rehabilitation technology has been the Rehabilitation Engineering Research Centers (RERCs) sponsored by the National Institute on Disability, Independent Living, and Rehabilitation Research...
November 6, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29104930/brain-and-behavioral-assessment-of-executive-functions-for-self-regulating-levels-of-language-in-reading-brain
#9
Virginia W Berninger, Todd L Richards, Robert D Abbott
This brief research report examines brain-behavioral relationships specific to levels of language in the complex reading brain. The first specific aim was to examine prior findings for significant fMRI connectivity from four seeds (left precuneus, left occipital temporal, left supramarginal, left inferior frontal) for each of four levels of language-subword, word (word-specific spelling or affixed words), syntax (with and without homonym foils or affix foils), and multi-sentence text to identify significant fMRI connectivity (a) unique to the lower level of language when compared to the immediately higher adjacent level of language across subword-word, word-syntax, and syntax-text comparisons; and (b) involving a brain region associated with executive functions...
November 2017: Journal of Nature and Science
https://www.readbyqxmd.com/read/29080434/potential-and-challenges-for-learning-during-acute-medical-surgical-placement-for-intellectual-disability-mental-health-and-midwifery-students
#10
Jane Mc Carthy, Margaret M Graham, Dympna Tuohy, Brid O'Brien, Anne Fahy, Therese Hennessy, Deirdre O'Sullivan, Kathleen Markey
In Ireland nursing and midwifery degree programmes involve four pathways to registration. Three of which, intellectual disability and mental health nursing and midwifery require students to undertake acute medical/surgical placements offering learning opportunities caring for patients with complex needs in settings beyond their core discipline. This paper focuses on findings from a descriptive qualitative study exploring intellectual disability and mental health nursing and midwifery students experiences of such placements...
October 18, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29078104/modeling-individual-variation-in-early-literacy-skills-in-kindergarten-children-with-intellectual-disabilities
#11
Arjan van Tilborg, Eliane Segers, Hans van Balkom, Ludo Verhoeven
In the present study, we investigated (i) to what extent the early literacy skills (phonological awareness, letter knowledge, and word decoding) along with cognitive (nonverbal reasoning, attention, phonological short-term memory, sequential memory, executive functioning) and linguistic (auditory discrimination, rapid naming, articulation, vocabulary) precursor measures of 53 six-year old children with intellectual disabilities (ID) differ from a group of 74 peers with normal language acquisition (NLA) and (ii) whether the individual variation of early literacy skills in the two groups to the same extent can be explained from the precursor measures...
October 24, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29075834/sequence-specific-implicit-motor-learning-using-whole-arm-three-dimensional-reach-movements
#12
Jessica Baird, Jill Campbell Stewart
Implicit motor learning is essential to the acquisition of motor skills. Examination of implicit motor learning, however, has largely involved single-finger button presses or two-dimensional movements of a computer mouse or joystick. The purpose of this study was to examine sequence-specific implicit motor learning during practice of  a three-dimensional (3D) whole-arm reach task. Fifteen young, non-disabled individuals completed two consecutive days of practice of a 3D target task presented in a virtual environment with the dominant, right arm...
October 26, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29075560/deletion-of-fmr1-results-in-sex-specific-changes-in-behavior
#13
Suzanne O Nolan, Conner D Reynolds, Gregory D Smith, Andrew J Holley, Brianna Escobar, Matthew A Chandler, Megan Volquardsen, Taylor Jefferson, Ashvini Pandian, Tileena Smith, Jessica Huebschman, Joaquin N Lugo
OBJECTIVE: In this study, we used a systemic Fmr1 knockout in order to investigate both genotype- and sex-specific differences across multiple measures of sociability, repetitive behaviors, activity levels, anxiety, and fear-related learning and memory. BACKGROUND: Fragile X syndrome is the most common monogenic cause of intellectual disability and autism. Few studies to date have examined sex differences in a mouse model of Fragile X syndrome, though clinical data support the idea of differences in both overall prevalence and phenotype between the sexes...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29074112/identifying-content-gaps-in-health-status-measures-for-intermittent-claudication-using-the-international-classification-of-functioning-disability-and-health
#14
David S Kauvar, Candice L Osborne
OBJECTIVE: The Walking Impairment Questionnaire (WIQ) and Intermittent Claudication Questionnaire (ICQ) are commonly used patient-reported functional outcome measures for intermittent claudication, but their functional representation has not been characterized. The World Health Organization's International Classification of Functioning, Disability and Health (ICF) framework comprehensively describes health-related function and has been used to evaluate health status and quality of life (QOL) measures...
October 23, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29062760/the-experiences-and-challenges-faced-by-rehabilitation-community-service-therapists-within-the-south-african-primary-healthcare-health-system
#15
Lieketseng Ned, Lizahn Cloete, Gubela Mji
BACKGROUND: Twenty-two years after the promulgation of a plethora of progressive health policies since 1994, the South African public health system reflects a number of stumbling blocks regarding implementation. Rehabilitation professionals are not sufficiently equipped nor allowed the opportunity to comprehensively implement Primary Healthcare (PHC) from a bottom-up approach, thus engaging communities. Training on addressing social health determinants and their impact on ill-health and health outcomes is inadequate...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/29061717/identifying-people-with-a-learning-disability-an-advanced-search-for-general-practice
#16
Amy M Russell, Louise Bryant, Allan House
BACKGROUND: People with learning disabilities (LD) have poor physical and mental health when compared with the general population. They are also likely to find it more difficult than others to describe their symptoms adequately. It is therefore harder for healthcare workers to identify the health needs of those with learning disabilities, with the danger of some problems being left unrecognised. Practice registers record only a proportion of those who are eligible, making it difficult to target improvements in their health care...
October 23, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29060546/automated-subdural-hematoma-segmentation-for-traumatic-brain-injured-tbi-patients
#17
Negar Farzaneh, S M Reza Soroushmehr, Craig A Williamson, Cheng Jiang, Ashok Srinivasan, Jayapalli R Bapuraj, Kevin R Ward, Frederick K Korley, Kayvan Najarian
Traumatic brain injury is a serious public health problem in the U.S. contributing to a large portion of permanent disability. However, its early management and treatment could limit the impact of the injury, save lives and reduce the burden of cost for patients as well as healthcare systems. Subdural hematoma is one of the most common types of TBI, which its visual detection and quantitative evaluation are time consuming and prone to error. In this study, we propose a fully auto-mated machine learning based approach for 3D segmentation of convexity subdural hematomas...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060142/classification-of-voluntary-coughs-applied-to-the-screening-of-respiratory-disease
#18
Christian Infante, Daniel B Chamberlain, Rahul Kodgule, Richard Ribon Fletcher
Pulmonary and respiratory diseases (e.g. asthma, COPD, allergies, pneumonia, tuberculosis, etc.) represent a large proportion of the global disease burden, mortality, and disability. In this context of creating automated diagnostic tools, we explore how the analysis of voluntary cough sounds may be used to screen for pulmonary disease. As a clinical study, voluntary coughs were recorded using a custom mobile phone stethoscope from 54 patients, of which 7 had COPD, 15 had asthma, 11 had allergic rhinitis, 17 had both asthma and allergic rhinitis, and four had both COPD and allergic rhinitis...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059494/molecular-based-diagnosis-of-multiple-sclerosis-and-its-progressive-stage
#19
Christopher Barbour, Peter Kosa, Mika Komori, Makoto Tanigawa, Ruturaj Masvekar, Tianxia Wu, Kory Johnson, Panagiotis Douvaras, Valentina Fossati, Ronald Herbst, Yue Wang, Keith Tan, Mark Greenwood, Bibiana Bielekova
OBJECTIVE: Biomarkers aid diagnosis, allow inexpensive screening of therapies and guide selection of patient-specific therapeutic regimens in most internal medicine disciplines. In contrast, neurology lacks validated measurements of the physiological status, or dysfunction(s) of cells of the central nervous system (CNS). Accordingly, patients with chronic neurological diseases are often treated with a single disease-modifying therapy without understanding patient-specific drivers of disability...
October 23, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29057368/intervention-development-for-the-indicated-prevention-of-depression-in-later-life-the-dil-protocol-in-goa-india
#20
Amit Dias, Fredric Azariah, Public Health, Alex Cohen, Stewart Anderson, Jennifer Morse, Pim Cuijpers, Miriam Sequeira, M A Psychology, Vithoba Gaude, Salvino Soares, Vikram Patel, Charles F Reynolds
Because depression is a major source of the global burden of illness- related disability, developing effective strategies for reducing its incidence is an important public health priority, especially in low-income countries, where resources for treating depression are scarce. We describe in this report an intervention development project, funded by the US National Institute of Mental Health, to address "indicated" prevention of depression in older adults attending rural and urban primary care clinics in Goa, India...
June 2017: Contemporary Clinical Trials Communications
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