Sisyphus

This article responds to a call from Philosophy of Management (Vandekerckhove 2020) to open a discussion on the contribution of Albert Camus's work to management. The aim of this article is to argue that Camus's sense of cyclicality related to the recurrence of crises is particularly important for existential management. This idea is embodied primarily by Camus's famous retelling of the myth of Sisyphus, which is not only a provocative metaphor of his thoughts, as discussed by many authors, but is also an inspiring expression of the idea of ​​revolt, which is further developed in Camus's later work...

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No abstract text is available yet for this article.

No abstract text is available yet for this article.

In Arabidopsis , LTR retrotransposons are activated by mutations in the chromatin gene DECREASE in DNA METHYLATION 1 ( DDM1 ), giving rise to 21- to 22-nt epigenetically activated siRNA (easiRNA) that depend on RNA DEPENDENT RNA POLYMERASE 6 (RDR6). We purified virus-like particles (VLPs) from ddm1 and ddm1rdr6 mutants in which genomic RNA is reverse transcribed into complementary DNA. High-throughput short-read and long-read sequencing of VLP DNA (VLP DNA-seq) revealed a comprehensive catalog of active LTR retrotransposons without the need for mapping transposition, as well as independent of genomic copy number...

BACKGROUND AND AIM OF THE WORK: Suicide is a worldwide phenomenon, with a relevant number of victims. Moreover, repercussions of suicidality-across its entire spectrum-involve not only the individual but also survivors and communities, in a profound and lasting way. As such, suicidality represents a crucial public mental health concern, in which risk/protection factors' study represent a key issue. However, research primarily focused on suicidality risk factors. This study, moving from Frankl's first observations on "Meaning in Life" (MiL) as protective against suicidality, aimed to identify the main themes that suicidal patients identified as MiL carriers, or potential carriers, in their existences...

In March 2017, we joined a multi-disciplinary expedition on Lake Onego, in the Russian Karelia, with the primary goal to investigate zooplankton strategies to survive deep winter under ice. We intended to focus on the large zooplankters, i.e. crustaceans of tenths to a few mm of body length, through sampling by horizontal and vertical trawls using nets of relatively large mesh-size. Delays in the delivery of sampling gear compelled us to opt, at the last minute, for a much-smaller mesh size net for the horizontal trawls underneath ice...

Perseverance in foraging is a high-risk/high-gain strategy. In this issue of Neuron, Sayin et al. (2019) decipher the neuronal circuit that arbitrates this choice in Drosophila. The fly's remarkable tenacity illuminates the interaction between working memory and decision making.

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We demonstrate that nonconvex Lagrangians, as contemplated in the theory of time crystals, can arise in the effective description of conventional, physically realizable systems. Such embeddings resolve dynamical singularities which arise in the reduced description. Microstructure featuring intervals of fixed velocity interrupted by quick resets-"Sisyphus dynamics"-is a generic consequence. In quantum mechanics, this microstructure can be blurred, leaving entirely regular behavior.

The number of breast cancer (BC) survivors has been increasing lately, due to the improvement in early detection strategies and oncological treatments. However, BC survivors are 3 times as likely to develop heart failure (HF) within 5 years of cancer diagnosis, and 7/100 of them will develop HF in a median follow-up of 8.5 years. Furthermore, HF in BC survivors has a worse prognosis compared to other causes of HF. Anthracyclines and trastuzumab have been proven to improve survival. However, they are also considered as the main causative factors of HF in BC survivors...

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We demonstrate single-atom resolved imaging with a survival probability of 0.99932(8) and a fidelity of 0.99991(1), enabling us to perform repeated high-fidelity imaging of single atoms in tweezers thousands of times. We further observe lifetimes under laser cooling of more than seven minutes, an order of magnitude longer than in previous tweezer studies. Experiments are performed with strontium atoms in 813.4 nm tweezer arrays, which is at a magic wavelength for the clock transition. Tuning to this wavelength is enabled by off-magic Sisyphus cooling on the intercombination line, which lets us choose the tweezer wavelength almost arbitrarily...

Here, we describe a web server that integrates structural alignments with the MAFFT multiple sequence alignment (MSA) tool. For this purpose, we have prepared a web-based Database of Aligned Structural Homologs (DASH), which provides structural alignments at the domain and chain levels for all proteins in the Protein Data Bank (PDB), and can be queried interactively or by a simple REST-like API. MAFFT-DASH integration can be invoked with a single flag on either the web (https://mafft.cbrc.jp/alignment/server/) or command-line versions of MAFFT...

To transport their balls of dung along a constant bearing, diurnal savannah-living dung beetles rely primarily on the sun for compass information. However, in more cluttered environments, such as woodlands, this solitary compass cue is frequently hidden from view by surrounding vegetation. In these types of habitats, insects can, instead, rely on surrounding landmarks, the canopy pattern, or wide-field celestial cues, such as polarised skylight, for directional information. Here, we investigate the compass orientation strategy behind straight-line orientation in the diurnal woodland-living beetle Sisyphus fasciculatus...

The determination of a substrate or enzyme activity by coupling one enzymatic reaction with another easily detectable (indicator) reaction is a common practice in the biochemical sciences. Usually, the kinetics of enzyme reactions is simplified with singular perturbation analysis to derive rate or time course expressions valid under the quasi-steady-state and reactant stationary state assumptions. In this paper, the dynamical behavior of coupled enzyme catalyzed reaction mechanisms is studied by analysis of the phase-plane...

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No abstract text is available yet for this article.

No abstract text is available yet for this article.