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"Antineutrophil cytoplasmic autoantibodies"

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https://www.readbyqxmd.com/read/27805540/massive-bitemporal-hemorrhages-in-antineutrophil-cytoplasmic-autoantibodies-vasculitis
#1
David Bergeron, Annie Dionne, Raphaël Marchand, Robert Laforce
No abstract text is available yet for this article.
November 2, 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27714710/cardiac-manifestations-in-antineutrophil-cytoplasmic-autoantibody-anca-associated-vasculitides
#2
Katarzyna Życińska, Anna Borowiec
No abstract text is available yet for this article.
October 7, 2016: Kardiologia Polska
https://www.readbyqxmd.com/read/27596099/pathogenesis-and-treatment-of-anca-associated-vasculitis-a-role-for-complement
#3
Damien Noone, Diane Hebert, Christoph Licht
The antineutrophil cytoplasm autoantibody (ANCA)-associated vasculitides (AAV), although rare in childhood, can have devastating effects on affected organs, especially the kidney. In this review we present an update on the pathogenesis and treatment of ANCA vasculitis, with a particular emphasis on the role of the alternative pathway of complement. The rationale and evidence for the current treatment strategies are summarized. Targeting the activation of neutrophils by the anaphylatoxin C5a may serve as an additional therapeutic strategy, however the results of clinical studies are awaited...
September 5, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27536680/overview-of-the-pathogenesis-of-anca-associated-vasculitis
#4
REVIEW
Hong Xiao, Peiqi Hu, Ronald J Falk, J Charles Jennette
BACKGROUND: Antineutrophil cytoplasmic autoantibodies (ANCA) are associated with a spectrum of necrotizing vasculitis including granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, and renal-limited necrotizing and crescentic glomerulonephritis. Clinical observations and in vitro and in vivo experimental evidence strongly indicate that ANCA are pathogenic. SUMMARY: The etiology and pathogenesis of ANCA-associated vasculitis (AAV) are multifactorial, with contributions from genetic factors, environmental exposures, infections, characteristics of the innate and adaptive immune system, and the intensity and duration of the injury...
March 2016: Kidney Diseases
https://www.readbyqxmd.com/read/27530224/pyogenic-arthritis-pyoderma-gangrenosum-acne-suppurative-hidradenitis-pa-pash-syndrome-an-atypical-presentation-of-a-rare-syndrome
#5
Mohammad A Ursani, Joan Appleyard, Onome Whiteru
BACKGROUND Pyogenic arthritis, pyoderma gangrenosum (PG), acne, and suppurative hidradenitis (PA-PASH) syndrome has been linked to an auto-inflammatory pathway. We report a case that is an atypical presentation of a rare syndrome, which supports literature suggesting that different phenotypes of PG-related syndromes may be a variation of the same pathogenic spectrum. Interestingly, our patient displayed a positive proteinase-3 antibody (PR-3). The clinical relevance of this is unclear. In recent literature, antineutrophil cytoplasmic autoantibodies (ANCA) positivity has been reported in various inflammatory conditions other than ANCA-associated vasculitis (AAV)...
2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27461086/long-term-outcomes-in-antineutrophil-cytoplasmic-autoantibody-positive-eosinophilic-granulomatosis-with-polyangiitis-patients-with-renal-involvement-a-retrospective-study-of-14-chinese-patients
#6
Yinghua Chen, Yuemei Ding, Zhengzhao Liu, Haitao Zhang, Zhihong Liu, Weixin Hu
BACKGROUND: The clinic-pathological features and outcomes of Chinese patients with antineutrophil cytoplasmic autoantibody (ANCA)-positive eosinophilic granulomatosis with polyangiitis (EGPA) and renal involvement have not been studied. METHODS: Fourteen EGPA patients with renal involvement were included. All patients underwent renal biopsy. Clinic-pathological features and outcomes were retrospectively analyzed. RESULTS: The most common initial symptom of EGPA was asthma (57...
July 26, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27449465/a-rare-case-of-florid-antineutrophil-cytoplasmic-autoantibody-associated-vasculitis-involving-both-atrioventricular-valves
#7
Habib Khan, Sanjay Chaubey, Rynda Nitiahpapand, Jatin Desai
Cardiac involvement is rare in antineutrophil cytoplasmic autoantibody (ANCA)-associated systemic vasculitis but can involve aortic and mitral valves. We present an unusual case of a 65-year-old woman who presented 16 years after an aortic valve replacement with severe mitral regurgitation with ACNA-associated vasculitis. The extensive nature of the pathologic condition, which extended to the tricuspid valve, prevented the replacement of the mitral valve during a surgical procedure. This is a rare case in which florid valvulopathy was observed in association with vasculitis...
August 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27418985/autoantibodies-in-a-three-year-old-girl-with-visceral-leishmaniasis-a-potential-diagnostic-pitfall
#8
Gholamreza Pouladfar, Zahra Jafarpour, Amir Hossein Babaei, Bahman Pourabbas, Bita Geramizadeh, Anahita Sanaei Dashti
Visceral leishmaniasis (VL), a life-threatening parasitic infection, is endemic in the Mediterranean region. Diagnosis of VL is based on epidemiologic, clinical, and laboratory findings. However, sometimes, clinical features and laboratory findings overlap with those of autoimmune diseases. In some cases, autoantibodies are detected in patients with VL and this could be a potential diagnostic pitfall. In this study, we have reported on a three-year-old girl from a VL-endemic area in Iran, who presented with prolonged fever and splenomegaly...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/26948291/double-filtration-plasmapheresis-in-the-treatment-of-antineutrophil-cytoplasmic-autoantibody-associated-vasculitis-with-severe-renal-failure-a-preliminary-study-of-15-patients
#9
Yinghua Chen, Liu Yang, Kang Li, Zhengzhao Liu, Dehua Gong, Haitao Zhang, Zhihong Liu, Weixin Hu
Our aim was to investigate the clinical efficacy of double filtration plasmapheresis (DFPP) in the treatment of antineutrophil cytoplasmic autoantibody-(ANCA) associated vasculitis (AAV) with severe renal involvement. Fifteen AAV patients who had severe renal failure (median SCr 5.6(IQR 5.2-9.0) mg/dL) and needed initial renal replacement therapy (RRT) were treated with DFPP and immunosuppressive therapy. Two plasma volumes were processed during each DFPP session. The changes of serum ANCA and renal function were investigated...
April 2016: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/26923204/plasma-cells-as-an-innovative-target-in-autoimmune-disease-with-renal-manifestations
#10
REVIEW
Falk Hiepe, Andreas Radbruch
Autoantibodies are secreted by plasma cells and have an essential role in driving the renal manifestations of autoimmune diseases such as systemic lupus erythematosus and antineutrophil cytoplasmic autoantibody-associated vasculitis. Effective depletion of autoreactive plasma cells might be the key to curative treatment of these diseases. Two major plasma-cell compartments exist: short-lived plasmablasts or plasma cells, which result from differentiation of activated B cells, and long-lived plasma cells, which result from secondary immune responses...
April 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/26913718/-effector-memory-t%C3%A2-cells-in-the-pathogenesis-of-anca-associated-vasculitides-german-version
#11
A Kerstein, A Müller, D Kabelitz, P Lamprecht
Patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) have an expansion of effector memory T‑cells in peripheral blood. The enlarged effector memory cell population contains distinct cell subsets, including T‑helper type 1 (Th1) CD4+ T‑cells lacking co-stimulatory CD28 expression and Th17 cells in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) and Th2 type and Th17 cells in eosinophilic granulomatosis with polyangiitis (EGPA). The cytokine response of autoreactive proteinase 3 (PR3)-specific effector memory T‑cells is skewed towards an increase of Th2 type, Th17 and Th22 cell fractions in GPA...
March 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/26913717/effector-memory-t%C3%A2-cells-in-the-pathogenesis-of-anca-associated-vasculitides
#12
A Kerstein, A Müller, D Kabelitz, P Lamprecht
Patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) have an expansion of effector memory T‑cells in peripheral blood. The enlarged effector memory cell population contains distinct cell subsets, including T‑helper type 1 (Th1) CD4(+) T‑cells lacking co-stimulatory CD28 expression and Th17 cells in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) and Th2 type and Th17 cells in eosinophilic granulomatosis with polyangiitis (EGPA). The cytokine response of autoreactive proteinase 3 (PR3)-specific effector memory T‑cells is skewed towards an increase of Th2 type, Th17, and Th22 cell fractions in GPA...
February 25, 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/26876879/the-lung-in-systemic-vasculitis-radiological-patterns-and-differential-diagnosis
#13
REVIEW
Beatrice Feragalli, Cesare Mantini, Marco Sperandeo, Michele Galluzzo, Giovanni Belcaro, Armando Tartaro, Antonio R Cotroneo
The respiratory system may be involved in all systemic vasculitides, although with a variable frequency. The aim of our review is to describe radiographic and high-resolution CT (HRCT) findings of pulmonary vasculitides and to correlate radiological findings with pathological results. Lung disease is a common feature of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitides, including granulomatosis with polyangiitis (Wegener's), eosinophilic granulomatosis with polyangiitis (Churg-Strauss) and microscopic polyangiitis...
2016: British Journal of Radiology
https://www.readbyqxmd.com/read/26841801/the-transition-of-renal-histopathology-after-immunosuppressive-therapy-in-a-woman-with-renal-limited-anca-associated-vasculitis-a-case-report-and-literature-review
#14
REVIEW
Xiang-Yang Li, Ying-Shan Liang, Pearl Pai
OBJECTIVES: The kidneys are frequently involved in antineutrophil cytoplasmic autoantibody (ANCA) associated small-vessel vasculitis (AASVV). The pathological hallmark of ANCA-associated glomerulonephritis (AAGN) is a pauci-immune necrotising crescentic glomerulonephritis. The histopathology of AAGN may change during the course of the disease as a consequence of immunosuppressive therapy. Herein, we report the pathological evolution of a case of AAGN. METHODS: We report a female presented with renal-limited AASVV, hypocomplementemia and nephrotic syndrome...
May 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/26608931/acute-hemorrhagic-edema-of-young-children-a-prospective-case-series
#15
Alessandra Ferrarini, Cecilia Benetti, Pietro Camozzi, Alessandro Ostini, Giacomo D Simonetti, Gregorio P Milani, Mario G Bianchetti, Sebastiano A G Lava
UNLABELLED: Acute hemorrhagic edema of young children is a rare leukocytoclastic vasculitis that has been reported exclusively in small retrospective cases series, case reports, or quizzes. Considering that retrospective experience deserves confirmation in at least one observational prospective study, we present our experience with 16 children (12 boys and 4 girls, 5-28 months of age) affected by acute hemorrhagic edema. The patients were in good general conditions and with a low-grade or even absent fever...
April 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/26599379/b-cell-targeted-therapy-in-systemic-vasculitis
#16
REVIEW
Lindsay Lally, Robert Spiera
PURPOSE OF REVIEW: The present review discusses the evidence supporting the use of B-cell-targeted therapy in the treatment of various forms of systemic vasculitis with a focus on the use of rituximab (RTX), in the antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV). RECENT FINDINGS: Long-term follow-up of the two studies establishing the efficacy of a RTX-based induction regimen for severe AAV have demonstrated noninferiority of a single course of RTX compared with conventional therapy for remission maintenance...
January 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/26599378/usefulness-of-antineutrophil-cytoplasmic-autoantibodies-in-diagnosing-and-managing-systemic-vasculitis
#17
REVIEW
Cees G M Kallenberg
PURPOSE OF REVIEW: Antineutrophil cytoplasmic autoantibodies (ANCAs) are considered important diagnostic tests in the work-up of patients suspected of vasculitis. Here we discuss new developments in the methodology of testing, the pitfalls in using these tests as diagnostic tools, and the value of serial ANCA testing for the follow-up of patients with ANCA-associated vasculitis including treatment decisions. RECENT FINDINGS: Both the indirect immunofluorescence (IIF) test and antigen-specific assays should be performed...
January 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/26413270/clinical-features-of-iga-nephropathy-with-serum-anca-positivity-a-retrospective-case-control-study
#18
Ya-Zi Yang, Su-Fang Shi, Yu-Qing Chen, Min Chen, Yi-He Yang, Xin-Fang Xie, Rong Zou, Ji-Cheng Lv, Li-Jun Liu, Hong Zhang
BACKGROUND: The coexistence of IgA nephropathy (IgAN) and antineutrophil cytoplasmic autoantibodies (ANCAs) is relatively rare. Only a few studies have reported the features of these patients. METHODS: We studied the clinical and histological features of 20 ANCA-positive IgAN patients. They were compared with ANCA-negative IgAN patients (n = 40) and ANCA-associated systemic vasculitis (AASV) patients (n = 40) with a randomly selected and matched proportion of crescentic glomeruli...
October 2015: Clinical Kidney Journal
https://www.readbyqxmd.com/read/26379042/significance-of-cd163-positive-macrophages-in-proliferative-glomerulonephritis
#19
Jun Li, Chang-Hua Liu, Dao-Liang Xu, Bo Gao
BACKGROUND: CD163, a marker of M2 macrophages, possesses anti-inflammatory properties. This study aims to investigate the clinicopathological significance of CD163-positive macrophages in proliferative glomerulonephritis. METHODS: Renal tissue samples from patients with lupus nephritis (LN, n = 22), antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune necrotizing glomerulonephritis (PNGN, n = 10), type 1 membranoproliferative glomerulonephritis (n = 5), minimal change disease (n = 8) and normal control kidneys (n = 3) were included in this study...
November 2015: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/26318749/induction-of-proteinase-3-anti-neutrophil-cytoplasmic-autoantibodies-by-proteinase-3-homologous-bacterial-protease-in-mice
#20
Yong Chul Kim, Yun Sik Choi, Jehan Alam, Yun-Ji Kim, Keum Jin Baek, Jaemoon Koh, Yeong Wook Song, Doo-Hyun Chung, Youngnim Choi
Proteinase 3 (PR3) is the principal target of antineutrophil cytoplasmic autoantibodies (ANCA) associated with granulomatosis with polyangiitis. The aim of this study was to investigate whether bacterial PR3-homologous protease can induce autoantibodies to PR3 and ANCA-associated pathology in mice. Among the bacterial proteases that have greater than 30 % identity with PR3, a trypsin-like serine protease of Saccharomonospora viridis, a bacterium that causes hypersensitivity pneumonitis, was chosen. When the mice were immunized with the recombinant protease of S...
April 2016: Immunologic Research
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