Shiwa Soukou-Wargalla, Christoph Kilian, Lis N Velasquez, Andres Machicote, Philine Letz, Huu Ban Tran, Saskia Domanig, Franziska Bertram, Friederike Stumme, Tanja Bedke, Anastasios Giannou, Jan Kempski, Morsal Sabihi, Ning Song, Hans-Joachim Paust, Alina Borchers, Laura Garcia Perez, Penelope Pelczar, Beibei Liu, Can Ergen, Babett Steglich, Franziska Muscate, Tobias B Huber, Ulf Panzer, Nicola Gagliani, Christian F Krebs, Samuel Huber
T regulatory type 1 (Tr1) cells, which are defined by their regulatory function, lack of Foxp3, and high expression of IL-10, CD49b, and LAG-3, are known to be able to suppress Th1 and Th17 in the intestine. Th1 and Th17 cells are also the main drivers of crescentic glomerulonephritis (GN), the most severe form of renal autoimmune disease. However, whether Tr1 cells emerge in renal inflammation and, moreover, whether they exhibit regulatory function during GN have not been thoroughly investigated yet. To address these questions, we used a mouse model of experimental crescentic GN and double Foxp3mRFP IL-10eGFP reporter mice...
October 18, 2023: Journal of Immunology