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https://www.readbyqxmd.com/read/28654465/high-velocity-paint-gun-injuries
#1
Wendi E Wohltmann, Joshua A Wisell, Celina M C Lafrades, Daniel M Cramer, Bruce D Ragsdale
Cutaneous injuries due to industrial high-pressure paint guns are well-documented in the literature; however, the histologic characteristics are uncommonly described, and facial involvement has not been previously reported. Histopathologic features of paint gun injuries vary depending on the time since injection and type of material. Early lesions display an acute neutrophilic infiltrate, edema, and thrombosis, with varying degrees of skin, fat, and muscle necrosis. More developed lesions (120-192 hours after injury) have prominent histiocytes and fibrosis around necrotic foci, possibly with the pitfall of muscle regenerative giant cells that could be mistaken for sarcoma...
June 20, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28654190/interobserver-variability-in-scoring-liver-biopsies-with-a-diagnosis-of-alcoholic-hepatitis
#2
Bela Horvath, Daniela Allende, Hao Xie, John Guirguis, Jennifer Jeung, James Lapinski, Deepa Patil, Arthur J McCullough, Srinivasan Dasarathy, Xiuli Liu
BACKGROUND: Alcoholic hepatitis (AH) is one of the most severe forms of alcoholic liver disease. Recently, a histologic scoring system for predicting prognosis in this patient cohort was proposed as Alcoholic Hepatitis Histologic Score (AHHS). We aimed to assess interobserver variability in recognizing histologic features of AH, and the effect of this variability on the proposed AHHS categories. DESIGN: Hematoxylin-eosin and trichrome stained slides from 32 patients diagnosed with AH with liver biopsies within 1 month of presentation (2000-2015), were reviewed by 5 pathologists including 3 liver pathologists and 2 gastrointestinal (GI) pathologists masked to the clinical findings or outcome...
June 27, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28653873/the-prognostic-value-of-pretreatment-neutrophil-to-lymphocyte-ratio-in-breast-cancer-deleterious-or-advantageous
#3
Qingqing Ou, Jiang Cheng, Licui Zhang, Huimin Wang, Wei Wang, Yajing Ma
Breast cancer is one of the leading malignant tumors that endanger women's health worldwide. Despite the rapid progress on the therapies, including chemotherapy, surgical resection, and other auxiliary methods, there were still numerous people died of breast cancer, which promoted the researchers to concentrate on the prognostic factor of breast cancer. In recent years, an increasing number of studies have been focused on the prognostic value of pretreatment neutrophil-to-lymphocyte ratio in breast cancer. This article is a brief review of the associations between neutrophil-to-lymphocyte ratio and the prognosis of breast cancer patients, which may give a greater insight into the development of breast cancer and enable clinicians to cure it completely...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28653439/intraepidermal-neutrophilic-dermatosis-type-of-iga-pemphigus-with-circulating-linear-iga-disease-antibodies-associated-with-ulcerative-colitis
#4
Eleni Papakonstantinou, Alexander Kapp, Marcel F Jonkman, Ulrike Raap
A 42-year-old woman with ulcerative colitis previously well controlled on mesalazine presented with blistering, crusts and severe itching on her upper body and legs together with painful erosions on her conjunctivae and oral mucous membranes in addition to active bowel symptoms for two weeks. Clinical examination revealed multiple lesions consisting of vesiculopustules with circinate distribution and central crusts in sunflower-like configuration on her flanks and legs, a typical characteristic of intraepidermal neutrophilic dermatosis (IEN)-type of IgA pemphigus (Figure 1A and 1C) [1]...
June 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28653372/the-effects-of-environmental-salinity-on-the-growth-and-physiology-of-totoaba-totoaba-macdonaldi-and-shortfin-corvina-cynoscion-parvipinnis
#5
M L González-Félix, M Perez-Velazquez, H Cañedo-Orihuela
Totoaba Totoaba macdonaldi and shortfin corvina Cynoscion parvipinnis, were acclimated and reared together at salinities of 0, 2, 5, 10, 20 and 35 for 56 days. Initial overall mean ± s.d. body masses of 67·6 ± 7·1 g T. macdonaldi and 37·3 ± 3·1 g C. parvipinnis increased to final overall masses of 217·4 ± 30·3 and 96·5 ± 16·5 g, respectively, at the end of the study. Totoaba macdonaldi was not able to tolerate salinities of 0 and 2 and C. parvipinnis of 0. In contrast, both species had 100% survival at salinities ≥ 10...
June 27, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28653285/innate-defense-regulator-idr-1018-activates-human-mast-cells-through-g-protein-phospholipase-c-mapk-and-nf-%C3%A4-b-sensitive-pathways
#6
Kensuke Yanashima, Panjit Chieosilapatham, Eri Yoshimoto, Ko Okumura, Hideoki Ogawa, François Niyonsaba
Host defense (antimicrobial) peptides not only display antimicrobial activities against numerous pathogens but also exert a broader spectrum of immune-modulating functions. Innate defense regulators (IDRs) are a class of host defense peptides synthetically developed from natural or endogenous cationic host defense peptides. Of the IDRs developed to date, IDR-1018 is more efficient not only in killing bacteria but also in regulating the various functions of macrophages and neutrophils and accelerating the wound healing process...
June 26, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28653226/urinary-biomarkers-in-the-early-detection-and-follow-up-of-tubular-injury-in-childhood-urolithiasis
#7
Mehmet Taşdemir, Dilara Fuçucuoğlu, Suat Hayri Küçük, Meltem Erol, Özgül Yiğit, Ilmay Bilge
BACKGROUND: To investigate relationships among urinary biomarkers [kidney injury molecule-1 (KIM-1), N-acetyl-β-glucosaminidase (NAG)], neutrophil gelatinase-associated lipocalin (NGAL) levels and renal tubular injury in childhood urolithiasis. METHODS: Seventy children [36 girls, mean age: 7.3 ± 5.0 years (0.5-18.2)] with urolithiasis/microlithiasis and 42 controls [18 girls, mean age: 8.5 ± 3.8 years (0.9-16.2)] were included in this multicenter, controlled, prospective cohort study...
June 26, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28652934/phytochemical-rich-medicinal-plant-extracts-suppress-bacterial-antigens-induced-inflammation-in-human-tonsil-epithelial-cells
#8
Niluni M Wijesundara, Satvir Sekhon-Loodu, Hp Vasantha Rupasinghe
BACKGROUND: Pharyngitis is an inflammatory condition of the pharynx and associated structures commonly caused by the Group A streptococci (GAS). There is a growing interest in discovering plant-based anti-inflammatory compounds as potential alternatives to conventional drugs. This study evaluated anti-inflammatory activity of phytochemical-rich extracts prepared from 12 herbal plants using human tonsil epithelial cells (HTonEpiC) in vitro. METHODS: The HTonEpiC were induced by a mixture of lipoteichoic acid (LTA) and peptidoglycan (PGN) (10 µg/mL; bacterial antigens) for 4 h and then exposed to ethanol extracts (EE) or aqueous extracts (AE) for 20 h...
2017: PeerJ
https://www.readbyqxmd.com/read/28652774/vasculogenic-mimicry-is-associated-with-increased-tumor-infiltrating-neutrophil-and-poor-outcome-in-esophageal-squamous-cell-carcinoma
#9
Jingxin Zhang, Guoxia Zhang, Pingping Hu, Guodong Deng, Qiqi Liu, Lili Qiao, Hui Luo, Jiandong Zhang
PURPOSE: Vasculogenic mimicry (VM) is known to be a mechanism to nourish the tumor, but little is known about its prognostic significance in esophageal squamous cell carcinoma (ESCC). We characterized the predictive relevance of VM expression and tumor-infiltrating neutrophil (TIN) density in patients with resectable ESCC. METHODS: We retrospectively collected clinicopathologic characteristics of 117 esophageal cancer (EC) patients undergoing complete resection and without preoperative therapy...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28652704/rhein-attenuates-inflammation-through-inhibition-of-nf-%C3%AE%C2%BAb-and-nalp3-inflammasome-in-vivo-and-in-vitro
#10
Hui Ge, Hao Tang, Yanbing Liang, Jingguo Wu, Qing Yang, Lijin Zeng, Zhongfu Ma
Rhein is an important component in traditional Chinese herbal medicine formulations for gastrointestinal disorders, including inflammatory bowel diseases such as ulcerative colitis. In this study, we investigated the beneficial effects of rhein in inflammation models in the transgenic zebrafish line TG (corolla eGFP), in which both macrophages and neutrophils express eGFP and RAW264.7 macrophages. We found that the tail-cutting-induced migration of immune cells was significantly reduced in transgenic zebrafish treated with rhein...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28652535/clinical-application-of-ghrelin-for-chronic-respiratory-failure
#11
Nobuhiro Matsumoto, Hironobu Tsubouchi, Yoshifumi Imazu, Yasuji Arimura, Shigehisa Yanagi, Hirotoshi Iiboshi, Masamitsu Nakazato
Chronic respiratory failure, which is often caused by chronic obstructive pulmonary disease, chronic lower respiratory tract infection, or interstitial pneumonia, often leads to cachexia with disease progression. Patients who have chronic respiratory failure with cachexia exhibit increased morbidity. Although cachectic status is an important clinical problem, there are no effective therapies for cachexia. Ghrelin has various effects, including increasing food intake, attenuating sympathetic nerve activity, inhibiting inflammation, increasing cardiac output, and controlling fat utilization...
2017: Endocrine Journal
https://www.readbyqxmd.com/read/28652447/clinical-predictors-for-neutrophil-to-lymphocyte-ratio-changes-in-patients-with-chronic-hepatitis-b-receiving-peginterferon-treatment
#12
Puo-Hsien LE, Kung-Hao Liang, Ming-Ling Chang, Chao-Wei Hsu, Yi-Cheng Chen, Chih-Lang Lin, Wey-Ran Lin, Ming-Wei Lai, Chau-Ting Yeh
BACKGROUND: A lower neutrophil-to-lymphocyte ratio (NLR) was found to be associated with better clinical outcomes in hepatitis B-related liver cirrhosis and hepatocellular carcinoma. We aimed to identify pre-therapeutic variables capable of predicting NLR changes in patients with hepatitis B receiving peginterferon therapy. PATIENTS AND METHODS: The baseline clinicopathological data were analyzed to correlate with NLR changes before and 1 year after peginterferon treatment in 71 patients with hepatitis B...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28652380/immune-escape-in-breast-cancer-during-in-situ-to-invasive-carcinoma-transition
#13
Carlos R Gil Del Alcazar, Sung Jin Huh, Muhammad B Ekram, Anne Trinh, Lin L Liu, Francisco Beca, Xiaoyuan Zi, Minsuk Kwak, Helga Bergholtz, Ying Su, Lina Ding, Hege G Russnes, Andrea L Richardson, Kirsten Babski, Elizabeth Min Hui Kim, Charles McDonnell, Jon Wagner, Ron Rowberry, Gordon J Freeman, Deborah Dillon, Therese Sorlie, Lisa M Coussens, Judy E Garber, Rong Fan, Kristie Bobolis, D Craig Allred, Joon Jeong, So Yeon Park, Franziska Michor, Kornelia Polyak
To investigate immune escape during breast tumor progression, we analyzed the composition of leukocytes in normal breast tissues, ductal carcinoma in situ (DCIS), and invasive ductal carcinomas (IDC). We found significant tissue and tumor subtype-specific differences in multiple cell types including T cells and neutrophils. Gene expression profiling of CD45+CD3+ T cells demonstrated a decrease in CD8+ signatures in IDCs. Immunofluorescence analysis showed fewer activated GZMB+CD8+ T cells in IDC than in DCIS, including in matched DCIS recurrent IDC...
June 26, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28652310/bacterial-nucleotidyl-cyclase-inhibits-host-innate-immune-response-through-suppressing-tak1-activation
#14
Chenxi He, Yilong Zhou, Feng Liu, Haipeng Liu, Hao Tan, Shouguang Jin, Weihui Wu, Baoxue Ge
Exoenzyme Y (ExoY) is a type III secretion system effector found in 90% of the Pseudomonas aeruginosa isolates. Although it is known that ExoY is a soluble nucleotidyl cyclase that increases the cytoplasmic levels of nucleoside 3' , 5' -cyclic monophosphates (cNMPs) to mediate endothelial Tau phosphorylation and permeability, its functional role in the innate immune response is still poorly understood. Transforming growth factor β activated kinase-1 (TAK1) is critical for mediating Toll-like receptor (TLR) signaling and subsequent activation of NF-κB and AP-1, which are transcriptional activators of innate immunity...
June 26, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28652245/unpaired-extracellular-cysteine-mutations-of-csf3r-mediate-gain-or-loss-of-function
#15
Haijiao Zhang, Sophie Means, Anna Reister Schultz, Kevin Watanabe-Smith, Bruno C Medeiros, Daniel Bottomly, Beth Wilmot, Shannon K McWeeney, Tim Kükenshöner, Oliver Hantschel, Jeffrey W Tyner
Exclusive of membrane-proximal mutations seen commonly in chronic neutrophilic leukemia (e.g. T618I), functionally defective mutations in the extracellular domain of the granulocyte colony-stimulating factor receptor (CSF3R) have been reported only in severe congenital and idiopathic neutropenia patients. Here we describe the first activating mutation in the fibronectin like type III domain of the extracellular region of CSF3R (W341C) in a leukemia patient. This mutation transformed cells via cysteine-mediated intermolecular disulfide bonds, leading to receptor dimerization...
June 26, 2017: Cancer Research
https://www.readbyqxmd.com/read/28652240/the-non-antibiotic-macrolide-em703-improves-survival-in-a-model-of-quinolone-treated-pseudomonas-aeruginosa-airway-infection
#16
Gopinath Kasetty, Ravi K V Bhongir, Praveen Papareddy, Heiko Herwald, Arne Egesten
Macrolide antibiotics are used as anti-inflammatory agents, e.g. for prevention of exacerbations in COPD and cystic fibrosis. Several studies have shown improved outcomes after addition of macrolides to beta-lactam antibiotics when treating severe community-acquired pneumonia. However, a beneficial effect of macrolides when treating Gram-negative bacterial airway infections, e.g. those caused by Pseudomonas aeruginosa, remains to be shown. Macrolide antibiotics have significant side effects, in particular motility-stimulating activity of the gastrointestinal tract and promotion of bacterial resistance...
June 26, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28652148/value-of-upper-endoscopic-biopsies-in-predicting-medical-refractoriness-in-pediatric-patients-with-ulcerative-colitis
#17
Katrina J Sullivan, Mike Wei, Elizabeth Chernetsova, Soufiane Hallani, Joseph de Nanassy, Eric I Benchimold, David R Mack, Ahmed Nasr, Dina El Demellawy
Refractory ulcerative colitis (UC) occurs in patients who experience a severe disease manifestation that is unresponsive to medical therapy. The assessment of upper endoscopic microscopic findings and its correlation with refractory UC has not been fully studied in pediatric patients, and is the focus of this study. Medical records of UC patients treated at a tertiary pediatric center between 2000 and 2014 were reviewed. Endoscopic biopsies of the upper gastrointestinal tract of patients meeting a priori inclusion criteria were compared between refractory UC patients and non-refractory UC patients for active inflammation...
June 23, 2017: Human Pathology
https://www.readbyqxmd.com/read/28651927/doxorubicin-plus-evofosfamide-versus-doxorubicin-alone-in-locally-advanced-unresectable-or-metastatic-soft-tissue-sarcoma-th-cr-406-sarc021-an-international-multicentre-open-label-randomised-phase-3-trial
#18
William D Tap, Zsuzsanna Papai, Brian A Van Tine, Steven Attia, Kristen N Ganjoo, Robin L Jones, Scott Schuetze, Damon Reed, Sant P Chawla, Richard F Riedel, Anders Krarup-Hansen, Maud Toulmonde, Isabelle Ray-Coquard, Peter Hohenberger, Giovanni Grignani, Lee D Cranmer, Scott Okuno, Mark Agulnik, William Read, Christopher W Ryan, Thierry Alcindor, Xavier F Garcia Del Muro, G Thomas Budd, Hussein Tawbi, Tillman Pearce, Stew Kroll, Denise K Reinke, Patrick Schöffski
BACKGROUND: Evofosfamide is a hypoxia-activated prodrug of bromo-isophosphoramide mustard. We aimed to assess the benefit of adding evofosfamide to doxorubicin as first-line therapy for advanced soft-tissue sarcomas. METHODS: We did this international, open-label, randomised, phase 3, multicentre trial (TH CR-406/SARC021) at 81 academic or community investigational sites in 13 countries. Eligible patients were aged 15 years or older with a diagnosis of an advanced unresectable or metastatic soft-tissue sarcoma, of intermediate or high grade, for which no standard curative therapy was available, an Eastern Cooperative Oncology Group performance status of 0-1, and measurable disease by Response Evaluation Criteria in Solid Tumors version 1...
June 23, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28651737/higher-neutrophil-counts-and-neutrophil-to-lymphocyte-ratio-predict-prognostic-outcomes-in%C3%A2-patients-after-non-atrial-fibrillation-caused-ischemic-stroke
#19
Yen-Nan Fang, Meng-Shen Tong, Pei-Hsun Sung, Yung-Lung Chen, Chih-Hung Chen, Nei-Wen Tsai, Chih-Jen Huang, Ya-Ting Chang, Shu-Fang Chen, Wen-Neng Chang, Cheng-Hsien Lu, Hon-Kan Yip
BACKGROUND: We aimed to determine whether higher neutrophil counts (NC) and neutrophil-to-lymphocyte ratio (NLR) were independently predictive of worse in-hospital outcome in patients after acute ischemic stroke (IS). METHODS: A retrospective observational study with prospective manner of IS registration. Between April 2012 and August 2014, a total number of 1731 patients with post-IS were consecutively enrolled in the study. Blood samples were drawn upon admission...
June 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28651665/using-milk-leukocyte-differentials-for-diagnosis-of-subclinical-bovine-mastitis
#20
Juliano Leonel Gonçalves, Roberta L Lyman, Mitchell Hockett, Rudy Rodriguez, Marcos Veiga Dos Santos, Kevin L Anderson
This research study aimed to evaluate the use of the milk leukocyte differential (MLD) to: (a) identify quarter milks that are culture-positive; and (b) characterize the milk leukocyte responses to specific groups of pathogens causing subclinical mastitis. The MLD measures the absolute number and relative percentage of inflammatory cells in milk samples. Using the MLD in two dairy herds (170 and 172 lactating cows, respectively), we studied all lactating cows with a most recent monthly Dairy Herd Improvement Association somatic cell count (SCC) >200 × 103 cells/ml...
June 27, 2017: Journal of Dairy Research
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