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influenza asthma

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https://www.readbyqxmd.com/read/29132960/influenza-derived-peptides-cross-react-with-allergens-and-provide-asthma-protection
#1
Chrysanthi Skevaki, Christoph Hudemann, Mikhail Matrosovich, Christian Möbs, Sinu Paul, Andreas Wachtendorf, Bilal Alashkar Alhamwe, Daniel P Potaczek, Stefanie Hagner, Diethard Gemsa, Holger Garn, Alessandro Sette, Harald Renz
BACKGROUND: The hygiene hypothesis is the leading concept to explain the current asthma epidemic, which is built on the observation that a lack of bacterial contact early in life induces allergic Th2 immune responses. OBJECTIVE: Since little is known about the contribution of respiratory viruses in this context, we evaluated the effect of prior influenza-infection on the development of allergic asthma. METHODS: Mice were infected with influenza and once recovered, subjected to an ovalbumin or house dust mite-induced experimental asthma protocol...
November 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29128032/acute-effects-of-ambient-air-pollution-on-lower-respiratory-infections-in-hanoi-children-an-eight-year-time-series-study
#2
Nguyen Thi Trang Nhung, Christian Schindler, Tran Minh Dien, Nicole Probst-Hensch, Laura Perez, Nino Künzli
BACKGROUND: Lower respiratory diseases are the most frequent causes of hospital admission in children worldwide, particularly in developing countries. Daily levels of air pollution are associated with lower respiratory diseases, as documented in many time-series studies. However, investigations in low-and-middle-income countries, such as Vietnam, remain sparse. OBJECTIVE: This study investigated the short-term association of ambient air pollution with daily counts of hospital admissions due to pneumonia, bronchitis and asthma among children aged 0-17 in Hanoi, Vietnam...
January 2018: Environment International
https://www.readbyqxmd.com/read/29105786/influenza-burden-prevention-and-treatment-in-asthma-a-scoping-review-by-the-eaaci-influenza-in-asthma-task-force
#3
REVIEW
Jürgen Schwarze, Peter Openshaw, Akhilesh Jha, Stefano R Del Giacco, Davide Firinu, Olympia Tsilochristou, Graham Roberts, Anna Selby, Cezmi Akdis, Ioana Agache, Adnan Custovic, Enrico Heffler, Georgia Pinna, Musa Khaitov, Alexandra Nikonova, Nikolaos Papadopoulos, Ather Akhlaq, Ulugbek Nurmatov, Harald Renz, Aziz Sheikh, Chrysanthi Skevaki
To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccine recommendations; vaccination coverage; immunogenicity, efficacy, effectiveness and safety of influenza vaccines; and the benefits of antiviral drugs in people with asthma. We found significant variation in the reported rates of influenza detection in individuals with acute asthma exacerbations making it unclear to what degree influenza causes exacerbations of underlying asthma...
November 6, 2017: Allergy
https://www.readbyqxmd.com/read/29089191/a-multi-site-feasibility-study-to-assess-fever-and-wheezing-in-children-after-influenza-vaccines-using-text-messaging
#4
Melissa S Stockwell, Colin D Marchant, A Patrica Wodi, Elizabeth D Barnett, Karen R Broder, Kathleen Jakob, Paige Lewis, Meyer Kattan, Anne Marie Rezendes, Angela Barrett, Devindra Sharma, Nadira Fernandez, Philip LaRussa
BACKGROUND: Using text messaging for vaccine safety monitoring, particularly for non-medically attended events, would be valuable for pandemic influenza and emergency vaccination program preparedness. We assessed the feasibility and acceptability of text messaging to evaluate fever and wheezing post-influenza vaccination in a prospective, observational, multi-site pediatric study. METHODS: Children aged 2-11 years old, with an emphasis on children with asthma, were recruited during the 2014-2015 influenza season from three community-based clinics in New York City, and during the 2014-2015 and 2015-2016 seasons from a private practice in Fall River, Massachusetts...
October 28, 2017: Vaccine
https://www.readbyqxmd.com/read/29049206/the-molecular-epidemiology-of-respiratory-viruses-associated-with-asthma-attacks-a-single-center-observational-study-in-japan
#5
Takeshi Saraya, Hirokazu Kimura, Daisuke Kurai, Haruyuki Ishii, Hajime Takizawa
Few reports have described the significance of viral respiratory infections (VRIs) in exacerbation of asthma in adult patients. The aim of this study was to elucidate the profiles of VRIs in adult patients with asthma along with their molecular epidemiology.A cross-sectional observational study was conducted at Kyorin University Hospital from August 2012 to May 2015. To identify respiratory pathogens in inpatients and outpatients suffering from asthma attacks, RT-PCR/sequencing/phylogenetic analysis methods were applied alongside conventional microbiological methods...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048277/retrospective-observational-study-of-atypical-winter-respiratory-illness-season-using-real-time-syndromic-surveillance-england-2014-15
#6
Sue Smith, Roger Morbey, Richard G Pebody, Thomas C Hughes, Simon de Lusignan, F Alex Yeates, Helen Thomas, Sarah J O'Brien, Gillian E Smith, Alex J Elliot
During winter 2014-15, England experienced severe strains on acute health services. We investigated whether syndromic surveillance could contribute to understanding of the unusually high level of healthcare needs. We compared trends for several respiratory syndromic indicators from that winter to historical baselines. Cumulative and mean incidence rates were compared by winter and age group. All-age influenza-like illness was at expected levels; however, severe asthma and pneumonia levels were above those expected...
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29042178/patterns-of-influenza-vaccination-coverage-in-the-united-states-from-2009-to-2015
#7
Alice P Y Chiu, Jonathan Dushoff, Duo Yu, Daihai He
BACKGROUND: Globally, influenza is a major cause of morbidity, hospitalization and mortality. Influenza vaccination has shown substantial protective effectiveness in the United States. METHODS: We investigated state-level patterns of coverage rates of seasonal and pandemic influenza vaccination, among the overall population (six months or older) in the U.S. and specifically among children (aged between 6 months and 17 years) and the elderly (aged 65 years or older), from 2009/10 to 2014/15, and associations with ecological factors...
October 14, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29033947/interferon-%C3%AE-s-front-line-guardians-of-immunity-and-homeostasis-in-the-respiratory-tract
#8
REVIEW
Evangelos Andreakos, Maria Salagianni, Ioanna E Galani, Ourania Koltsida
Type III interferons (IFNs), also termed lambda IFNs (IFNλs) or interleukins-28/29, constitute a new addition to the IFN family. They are induced upon infection and are particularly abundant at barrier surfaces, such as the respiratory and gastrointestinal tracts. Although they signal through a unique heterodimeric receptor complex comprising IFNLR1 and IL10RB, they activate a downstream signaling pathway remarkably similar to that of type I IFNs and share many functions with them. Yet, they also have important differences which are only now starting to unfold...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28975014/the-relative-burden-of-menopausal-and-postmenopausal-symptoms-versus-other-major-conditions-a-retrospective-analysis-of-the-medical-expenditure-panel-survey-data
#9
Annlouise R Assaf, Andrew G Bushmakin, Nina Joyce, Michael J Louie, Michael Flores, Margaret Moffatt
BACKGROUND: The direct costs associated with menopausal and postmenopausal symptoms (hereafter "menopausal symptoms") may include the costs of physician and emergency department visits, medications, laboratory testing, and the management of side effects. However, much remains unknown about the costs related to menopausal symptoms, including how they compare with the costs of other diseases that are common among menopausal women. OBJECTIVE: To compare the economic burden of menopausal symptoms with other select prevalent chronic conditions among a nationally representative sample of US menopausal women aged 45 to 65 years...
September 2017: American Health & Drug Benefits
https://www.readbyqxmd.com/read/28914750/live-attenuated-influenza-vaccination-prior-to-age-3-years-and-subsequent-development-of-asthma-a-14-year-follow-up-study
#10
Roger P Baxter, Ned Lewis, Bruce Fireman, John Hansen, Nicola P Klein, Justin R Ortiz
BACKGROUND: Live-attenuated influenza vaccines (LAIVs) are not licensed in children <2 years because of a wheezing safety signal that has not been fully elucidated. In 2000, the Kaiser Permanente Vaccine Study Center conducted a placebo controlled randomized clinical trial (RCT) of LAIV in children. As many of these children were still enrolled in Kaiser Permanente in 2014, we could assess the possible long-term association between LAIV and subsequent asthma diagnosis. METHODS: We identified all children who were originally enrolled into the LAIV RCT at < 3 years of age...
September 12, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28913991/seasonal-cycle-and-relationship-of-seasonal-rhino-and-influenza-virus-epidemics-with-episodes-of-asthma-exacerbation-in-different-age-groups
#11
Seung Won Lee, Shinhae Lee, Youn Ho Sheen, Eun Kyo Ha, Sun Hee Choi, Min Suk Yang, Sohyun Hwang, Sung Soon Kim, Jang Hoon Choi, Man Yong Han
PURPOSE: Seasonal variations in asthma exacerbation (AE) are associated with respiratory virus outbreaks and the return of children to school after vacation. This study aims to elucidate the period, phase, and amplitude of seasonal cycles of AE in 5 different age groups with regard to rhino- and influenza virus epidemics in Korea. METHODS: The number of daily emergency department (ED) visits for AE in all age groups of Korea and the nationwide weekly incidence of rhino- and influenza virus, were obtained for 2008-2012...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28913988/prevalence-of-respiratory-viral-infections-in-korean-adult-asthmatics-with-acute-exacerbations-comparison-with-those-with-stable-state
#12
Ki Hyun Seo, Da Jeong Bae, Ji Na Kim, Ho Sung Lee, Yong Hoon Kim, Jong Sook Park, Myung Shin Kim, Hun Soo Chang, Ji Hye Son, Dong Gyu Baek, Jun Suk Lee, Choon Sik Park
PURPOSE: Viral infections are involved in ~50% of exacerbations among Caucasian adult asthmatics. However, there have been few reports on the causative virus of exacerbations in Korean adult asthmatics. Thus, we compared frequencies and types of viruses between lower respiratory tract illnesses (LRTIs) with exacerbations (exacerbated LRTIs) and those without exacerbations (stable LRTIs) to evaluate contribution of respiratory viruses to exacerbations. METHODS: Viral RNA was extracted from sputum using the Viral Gene-spin™ Kit...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28889999/humoral-immune-responses-during-asthma-and-influenza-co-morbidity-in-mice
#13
Laura A Doorley, Kim S LeMessurier, Amy R Iverson, Maneesha Palipane, Amali E Samarasinghe
Humoral immunity serve dual functions of direct pathogen neutralization and enhancement of leukocyte function. Antibody classes are determined by antigen triggers, and the resulting antibodies can contribute to disease pathogenesis and host defense. Although asthma and influenza are immunologically distinct diseases, since we have found that allergic asthma exacerbation promotes antiviral host responses to influenza A virus, we hypothesized that humoral immunity may contribute to allergic host protection during influenza...
December 2017: Immunobiology
https://www.readbyqxmd.com/read/28880061/clinical-course-of-asthma-patients-with-h1n1-influenza-infection-and-oseltamivir
#14
Min-Hye Kim, Woo-Jung Song, Min-Suk Yang, So-Hee Lee, Jae-Woo Kwon, Sae-Hoon Kim, Hye-Ryun Kang, Heung-Woo Park, Young-Joo Cho, Sang-Heon Cho, Kyung-Up Min, You-Young Kim, Yoon-Seok Chang
BACKGROUND: H1N1 influenza virus prevailed throughout the world in 2009. However, there are few reports on the clinical features of H1N1 influenza infection in adult asthma patients. We evaluated the clinical features in asthma patients with H1N1 influenza infection who took oseltamivir and compared them to those with other upper respiratory infections. METHODS: We reviewed asthma patients over 15 years of age who had visited Seoul National University Hospital and Seoul National University Bundang Hospital for suspected H1N1 influenza infection from August 2009 to March 2010...
September 5, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28870461/enhanced-plasmacytoid-dendritic-cell-antiviral-responses-after-omalizumab
#15
Michelle A Gill, Andrew H Liu, Agustin Calatroni, Rebecca Z Krouse, Baomei Shao, Allison Schiltz, James E Gern, Alkis Togias, William W Busse
BACKGROUND: Atopy and viral respiratory tract infections synergistically promote asthma exacerbations. IgE cross-linking inhibits critical virus-induced IFN-α responses of plasmacytoid dendritic cells (pDCs), which can be deficient in patients with allergic asthma. OBJECTIVE: We sought to determine whether reducing IgE levels in vivo with omalizumab treatment increases pDC antiviral IFN-α responses in inner-city children with asthma. METHODS: PBMCs and pDCs isolated from children with exacerbation-prone asthma before and during omalizumab treatment were stimulated ex vivo with rhinovirus and influenza in the presence or absence of IgE cross-linking...
September 1, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28852915/evaluation-of-pharmacist-initiated-interventions-on-vaccination-rates-in-patients-with-asthma-or-copd
#16
Haley M Klassing, Janelle F Ruisinger, Emily S Prohaska, Brittany L Melton
To determine if pharmacy-initiated interventions improved the rate of influenza and pneumococcal vaccinations in adult patients with asthma and/or chronic obstructive pulmonary disease (COPD). Adult patients who filled prescriptions at one of three community pharmacies, who had a dispensing history indicative of an asthma and/or COPD diagnosis were randomized to receive a personal phone call or standardized mailed letter recommending influenza and pneumococcal vaccinations, or control with no vaccination information...
August 29, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28844189/prevalence-of-comorbidities-in-periodontitis-patients-compared-to-the-general-austrian-population
#17
Martina Sperr, Michael Kundi, Vernes Tursic, Margit Bristela, Andreas Moritz, Oleh Andrukhov, Xiaohui Rausch-Fan, Wolfgang R Sperr
BACKGROUND: To analyze the prevalence and impact of comorbidities in patients with periodontitis in Austria. METHODS: The prevalence of comorbidities was evaluated in 1199 patients with periodontitis (median age: 49, range: 14-83 years). These data were compared to an age and sex matched randomly selected cohort of the Austrian population by an unconditional logistic regression model. RESULTS: Comorbidities were found in 821/1199=68.5% patients...
August 28, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28831046/pulmonary-inflammation-and-cytokine-dynamics-of-bronchoalveolar-lavage-fluid-from-a-mouse-model-of-bronchial-asthma-during-a-h1n1-pdm09-influenza-infection
#18
Yousuke Fujimoto, Shunji Hasegawa, Takeshi Matsushige, Hiroyuki Wakiguchi, Tamaki Nakamura, Hideki Hasegawa, Noriko Nakajima, Akira Ainai, Atsunori Oga, Hiroshi Itoh, Komei Shirabe, Shoichi Toda, Ryo Atsuta, Tsuneo Morishima, Shouichi Ohga
Asthmatic patients present more rapid progression of respiratory distress after A(H1N1)pdm09 influenza infection than after seasonal infection. Here, we sought to clarify the pathophysiology of early deterioration in asthmatic patients after A(H1N1)pdm09 infection. Cytokine levels and virus titres in bronchoalveolar lavage fluid from mice with and without asthma after A(H1N1)pdm09 or seasonal H1N1 infection were examined. In asthma/A(H1N1)pdm09 mice, IL-6 and TNF-α levels peaked at 3 days post-infection and were higher than those in all other groups...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813449/influenza-virus-infections-among-patients-attending-emergency-department-according-to-main-reason-to-presenting-to-ed-a-3-year-prospective-observational-study-during-seasonal-epidemic-periods
#19
Enrique Casalino, Stephanie Antoniol, Nadhira Fidouh, Christophe Choquet, Jean-Christophe Lucet, Xavier Duval, Benoit Visseaux, Laurent Pereira
OBJECTIVE: The role of influenza virus in patients presenting at ED during seasonal-epidemic periods has not previously been specified. Our objective was to determine its frequency according to clinical presentation. METHODS: This is a prospective observational study conducted during three-consecutive seasonal Influenza epidemics (2013-2015), including patients presenting i) community-acquired pneumonia (CAP); ii) severe acute symptoms (SAS): respiratory failure (RF), hemodynamic failure (HF), cardiac failure (CF), and miscellaneous symptoms (M); iii) symptoms suggesting influenza (PSSI)...
2017: PloS One
https://www.readbyqxmd.com/read/28771405/pediatric-readmissions-after-hospitalizations-for-lower-respiratory-infections
#20
Mari M Nakamura, Alan M Zaslavsky, Sara L Toomey, Carter R Petty, Maria C Bryant, Alexandra T Geanacopoulos, Ashish K Jha, Mark A Schuster
BACKGROUND AND OBJECTIVE: Lower respiratory infections (LRIs) are among the most common reasons for pediatric hospitalization and among the diagnoses with the highest number of readmissions. Characterizing LRI readmissions would help guide efforts to prevent them. We assessed variation in pediatric LRI readmission rates, risk factors for readmission, and readmission diagnoses. METHODS: We analyzed 2008-2009 Medicaid Analytic eXtract data for patients <18 years of age in 26 states...
August 2017: Pediatrics
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