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Marek's disease virus

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https://www.readbyqxmd.com/read/28694799/a-tiny-rna-that-packs-a-big-punch-the-critical-role-of-a-viral-mir-155-ortholog-in-lymphomagenesis-in-marek-s-disease
#1
REVIEW
Guoqing Zhuang, Aijun Sun, Man Teng, Jun Luo
MicroRNAs (miRNAs) are small non-coding RNAs that have been identified in animals, plants, and viruses. These small RNAs play important roles in post-transcriptional regulation of various cellular processes, including development, differentiation, and all aspects of cancer biology. Rapid-onset T-cell lymphoma of chickens, namely Marek's disease (MD), induced by Gallid alphaherpesvirus 2 (GaHV2), could provide an ideal natural animal model for herpesvirus-related cancer research. GaHV2 encodes 26 mature miRNAs derived from 14 precursors assembled in three distinct gene clusters in the viral genome...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28677643/telomeres-and-telomerase-role-in-marek-s-disease-virus-pathogenesis-integration-and-tumorigenesis
#2
REVIEW
Ahmed Kheimar, Renato L Previdelli, Darren J Wight, Benedikt B Kaufer
Telomeres protect the ends of vertebrate chromosomes from deterioration and consist of tandem nucleotide repeats (TTAGGG)n that are associated with a number of proteins. Shortening of the telomeres occurs during genome replication, thereby limiting the replication potential of somatic cells. To counteract this shortening, vertebrates encode the telomerase complex that maintains telomere length in certain cell types via de novo addition of telomeric repeats. Several herpesviruses, including the highly oncogenic alphaherpesvirus Marek's disease virus (MDV), harbor telomeric repeats (TMR) identical to the host telomere sequences at the ends of their linear genomes...
July 4, 2017: Viruses
https://www.readbyqxmd.com/read/28665725/industry-wide-surveillance-of-marek-s-disease-virus-on-commercial-poultry-farms
#3
David A Kennedy, Christopher Cairns, Matthew J Jones, Andrew S Bell, Rahel M Salathé, Susan J Baigent, Venugopal K Nair, Patricia A Dunn, Andrew F Read
Marek's disease virus is a herpesvirus of chickens that costs the worldwide poultry industry more than US$1 billion annually. Two generations of Marek's disease vaccines have shown reduced efficacy over the last half century due to evolution of the virus. Understanding where the virus is present may give insight into whether continued reductions in efficacy are likely. We conducted a 3-yr surveillance study to assess the prevalence of Marek's disease virus on commercial poultry farms, determine the effect of various factors on virus prevalence, and document virus dynamics in broiler chicken houses over short (weeks) and long (years) timescales...
June 2017: Avian Diseases
https://www.readbyqxmd.com/read/28652615/gga-mir-219b-targeting-bcl11b-suppresses-proliferation-migration-and-invasion-of-marek-s-disease-tumor-cell-msb1
#4
Chunfang Zhao, Xin Li, Bo Han, Zhen You, Lujiang Qu, Changjun Liu, Jiuzhou Song, Ling Lian, Ning Yang
Marek's disease (MD), caused by Marek's disease virus (MDV), is a lymphotropic neoplastic disease. Previous miRNAome analysis showed gga-miR-219b was significantly downregulated in MDV-induced lymphoma, and one of its potential target genes, B-cell chronic lymphocytic /lymphoma 11B (BCL11B) was predicted. In this study, we further investigated the function of gga-miR-219b, and the gain/loss of function assay showed gga-miR-219b inhibited cell migration and reduced cell proliferation by promoting apoptosis not by cell cycle arrest...
June 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28635675/co-infection-with-marek-s-disease-virus-and-reticuloendotheliosis-virus-increases-illness-severity-and-reduces-marek-s-disease-vaccine-efficacy
#5
Guo-Rong Sun, Yan-Ping Zhang, Lin-Yi Zhou, Hong-Chao Lv, Feng Zhang, Kai Li, Yu-Long Gao, Xiao-Le Qi, Hong-Yu Cui, Yong-Qiang Wang, Li Gao, Qing Pan, Xiao-Mei Wang, Chang-Jun Liu
Marek's disease virus (MDV) and reticuloendotheliosis virus (REV) cause Marek's disease (MD) and reticuloendotheliosis (RE), respectively. Co-infection with MDV and REV is common in chickens, causing serious losses to the poultry industry. However, experimental studies of such co-infection are lacking. In this study, Chinese field strains of MDV (ZW/15) and REV (JLR1501) were used as challenge viruses to evaluate the pathogenicity of co-infection and the influence of MD vaccination in chickens. Compared to the MDV-challenged group, the mortality and tumor rates increased significantly by 20...
June 21, 2017: Viruses
https://www.readbyqxmd.com/read/28622640/clinical-course-and-core-variability-in-hbv-infected-patients-without-detectable-anti-hbc-antibodies
#6
Olympia E Anastasiou, Marek Widera, Jens Verheyen, Johannes Korth, Guido Gerken, Fabian A Helfritz, Ali Canbay, Heiner Wedemeyer, Sandra Ciesek
BACKGROUND: The presence of anti-HBc antibodies indicates direct encounter of the immune system with hepatitis B virus (HBV). OBJECTIVES: Aim of our study was to seek for anti-HBc negative but HBV replicating patients and analyze their clinical course and preconditions. STUDY DESIGN: From 1568 HBV-DNA positive patients, 29 patients (1.85%) tested negative for anti-HBc. The absence of anti-HBc could be confirmed in 19 patients using an alternative assay...
June 8, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28604814/functional-paralysis-of-gm-csf-derived-bone-marrow-cells-productively-infected-with-ectromelia-virus
#7
Lidia Szulc-Dąbrowska, Justyna Struzik, Agnieszka Ostrowska, Maciej Guzera, Felix N Toka, Magdalena Bossowska-Nowicka, Małgorzata M Gieryńska, Anna Winnicka, Zuzanna Nowak, Marek G Niemiałtowski
Ectromelia virus (ECTV) is an orthopoxvirus responsible for mousepox, a lethal disease of certain strains of mice that is similar to smallpox in humans, caused by variola virus (VARV). ECTV, similar to VARV, exhibits a narrow host range and has co-evolved with its natural host. Consequently, ECTV employs sophisticated and host-specific strategies to control the immune cells that are important for induction of antiviral immune response. In the present study we investigated the influence of ECTV infection on immune functions of murine GM-CSF-derived bone marrow cells (GM-BM), comprised of conventional dendritic cells (cDCs) and macrophages...
2017: PloS One
https://www.readbyqxmd.com/read/28591220/comparative-transcriptomics-of-genetically-divergent-lines-of-chickens-in-response-to-marek-s-disease-virus-challenge-at-cytolytic-phase
#8
Kunzhe Dong, Shuang Chang, Qingmei Xie, Alexis Black-Pyrkosz, Huanmin Zhang
Marek's disease (MD), caused by Marek's disease virus (MDV), remains an economically significant threat to the poultry industry worldwide. Genetic resistance to MD is a promising alternative strategy to augment current control measures (vaccination and management). However, only a few functional genes reportedly conferring MD resistance have been identified. Here, we performed a comparative transcriptomics analysis of two highly inbred yet genetically divergent lines of chickens (line 63 and 72) that are resistant and susceptible to MD, respectively, in response to a very virulent plus strain of MDV (vv+MDV) challenge at cytolytic phase...
2017: PloS One
https://www.readbyqxmd.com/read/28570620/viral-etiologies-in-adult-patients-with-encephalitis-in-poland-a-prospective-single-center-study
#9
Marta Popiel, Karol Perlejewski, Agnieszka Bednarska, Tomasz Dzieciątkowski, Marcin Paciorek, Dariusz Lipowski, Monika Jabłonowska, Hanna Czeszko-Paprocka, Iwona Bukowska-Ośko, Kamila Caraballo Cortes, Agnieszka Pawełczyk, Maria Fic, Andrzej Horban, Marek Radkowski, Tomasz Laskus
Encephalitis is a severe neurological syndrome associated with high morbidity and mortality as well as long-term neurological sequelae. Despite being an important public health problem, very few extensive population-based studies were conducted so far in the world and none in Central Europe. Altogether 114 consecutive patients meeting the initial criteria for encephalitis were enrolled at the Warsaw Hospital for Infectious Diseases between June 2012 and July 2015. Eighteen patients were secondarily excluded from the analysis due to incomplete data or noinfectious cause...
2017: PloS One
https://www.readbyqxmd.com/read/28548038/marek-s-disease-virus-infection-of-phagocytes-a-de-novo-in-vitro-infection-model
#10
Pankaj Chakraborty, Lonneke Vervelde, Robert G Dalziel, Peter S Wasson, Venugopal Nair, Bernadette M Dutia, Pete Kaiser
Marek's disease virus (MDV) is an alphaherpesvirus that induces T-cell lymphomas in chickens. Natural infections in vivo are caused by the inhalation of infected poultry house dust and it is presumed that MDV infection is initiated in the macrophages from where the infection is passed to B cells and activated T cells. Virus can be detected in B and T cells and macrophages in vivo, and both B and T cells can be infected in vitro. However, attempts to infect macrophages in vitro have not been successful. The aim of this study was to develop a model for infecting phagocytes [macrophages and dendritic cells (DCs)] with MDV in vitro and to characterize the infected cells...
May 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28532188/differential-amplification-of-marek-s-disease-cvi988-vaccine-and-of-wild-type-isolates-from-organs-of-commercial-chickens-using-single-or-duplexed-probes-in-real-time-pcr
#11
Irit Davidson, Amira Natour-Altoury, Israel Raibstein, Yaad Dahan
The DIVA test, based on the MDV pp38 gene was described by Baigent et al. (2016), using similar primers and alternate probes for virulent MDV-1 and the vaccine CVI988 virus. We now explored the assay applicability for commercial vaccines and for DNAs of commercial chickens, as former study employed tissue cultured prototype MDV strains and chicken tissue from experimental infection trials. DNA of chicken visceral organs and feathers of either vaccinated, or naturally-infected with virulent MDV-1 wild-type viruses was used for DIVA-PCR real-time PCR...
May 22, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28528445/interindividual-spread-of-herpesviruses
#12
Keith W Jarosinski
Interindividual spread of herpesviruses is essential for the virus life cycle and maintenance in host populations. For most herpesviruses, the virus-host relationship is close, having coevolved over millions of years resulting in comparatively high species specificity. The mechanisms governing interindividual spread or horizontal transmission are very complex, involving conserved herpesviral and cellular proteins during the attachment, entry, replication, and egress processes of infection. Also likely, specific herpesviruses have evolved unique viral and cellular interactions during cospeciation that are dependent on their relationship...
2017: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/28510513/putative-roles-as-oncogene-or-tumour-suppressor-of-the-mid-clustered-micrornas-in-gallid-alphaherpesvirus-2-gahv2-induced-marek-s-disease-lymphomagenesis
#13
Man Teng, Zu-Hua Yu, Pu Zhao, Guo-Qing Zhuang, Zi-Xiang Wu, Lu Dang, Hui-Zhen Li, Sheng-Ming Ma, Zhi-Zhong Cui, Gai-Ping Zhang, Run Wu, Jun Luo
In the last decade, numerous microRNAs (miRNAs) have been identified in diverse virus families, particularly in herpesviruses. Gallid alphaherpesvirus 2 (GaHV2) is a representative oncogenic alphaherpesvirus that induces rapid-onset T-cell lymphomas in its natural hosts, namely Marek's disease (MD). In the GaHV2 genome there are 26 mature miRNAs derived from 14 precursors assembled into three clusters, namely the Meq-cluster, Mid-cluster and LAT-cluster. Several GaHV2 miRNAs, especially those in the Meq-cluster (e...
May 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28475033/differentially-expressed-genes-during-spontaneous-lytic-switch-of-marek-s-disease-virus-in-lymphoblastoid-cell-lines-determined-by-global-gene-expression-profiling
#14
William N Mwangi, Deepali Vasoya, Lydia B Kgosana, Mick Watson, Venugopal Nair
Marek's disease virus (MDV), an alphaherpesvirus of poultry, causes Marek's disease and is characterized by visceral CD4+TCRαβ+ T-cell lymphomas in susceptible hosts. Immortal cell lines harbouring the viral genome have been generated from ex vivo cultures of MD tumours. As readily available sources of large numbers of cells, MDV-transformed lymphoblastoid cell lines (LCLs) are extremely valuable for studies of virus-host interaction. While the viral genome in most cells is held in a latent state, minor populations of cells display spontaneous reactivation identifiable by the expression of lytic viral genes...
April 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28414218/exploiting-the-anti-aggregation-of-gold-nanostars-for-rapid-detection-of-hand-foot-and-mouth-disease-causing-enterovirus-71-using-surface-enhanced-raman-spectroscopy
#15
Miguel Reyes, Marek Piotrowski, Swee Kim Ang, Jingqi Chan, Shuai He, Justin Jang Hann Chu, James Chen Yong Kah
Enterovirus 71 (EV71) is a major public health threat that requires rapid point-of-care detection. Here, we developed a surface-enhanced Raman spectroscopy (SERS)-based scheme that utilized protein-induced aggregation of colloidal gold nanostars (AuNS) to rapidly detect EV71 without the need for fabricating a solid substrate, Raman labels or complicated sample handling. We used AuNS (hydrodynamic diameter, DH of 105.12 ± 1.13 nm) conjugated to recombinant scavenger receptor class B, member 2 (SCARB2) protein with known affinity to EV71...
April 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28413051/protective-efficacy-of-a-novel-recombinant-marek-s-disease-virus-vector-vaccine-against-infectious-bursal-disease-in-chickens-with-or-without-maternal-antibodies
#16
Kai Li, Yongzhen Liu, Yanping Zhang, Li Gao, Changjun Liu, Hongyu Cui, Xiaole Qi, Yulong Gao, Li Zhong, Xiaomei Wang
Infectious bursal disease (IBD) causes significant clinical and economic losses to the poultry industry worldwide. Current vaccine programs using live attenuated and inactivated vaccines have numerous drawbacks. As an alternative solution to control IBD, a Marek's disease virus (MDV) vector vaccine (rMDV-VP2) expressing the VP2 gene of infectious bursal disease virus (IBDV) has been developed. In this study, the protective efficacy of rMDV-VP2 was evaluated in a dose-related experiment which showed that a single dose of 1000 PFU was sufficient to fully protect chickens against IBDV infection...
April 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28410454/transcriptomic-analysis-of-host-immune-response-in-the-skin-of-chickens-infected-with-marek-s-disease-virus
#17
Mohammad Heidari, Phillip C Delekta
Marek's disease virus (MDV), a highly cell-associated oncogenic α-herpesvirus, is the causative agent of T cell lymphoma and neuropathic disease called Marek's disease. The skin is the only anatomical site where infectious enveloped cell-free virions are produced and shed into the environment. Studies have demonstrated that MDV infection induces immunological responses within the skin, including the release of cytokines and the recruitment of T lymphocytes. The host immune response, however, is not sufficient to block replication and shedding of the virus particles from the skin...
June 2017: Viral Immunology
https://www.readbyqxmd.com/read/28406989/escdl-1-a-new-cell-line-derived-from-chicken-embryonic-stem-cells-supports-efficient-replication-of-mardiviruses
#18
Jean-François Vautherot, Christian Jean, Laetitia Fragnet-Trapp, Sylvie Rémy, Danièle Chabanne-Vautherot, Guillaume Montillet, Aurélie Fuet, Caroline Denesvre, Bertrand Pain
Marek's disease virus is the etiological agent of a major lymphoproliferative disorder in poultry and the prototype of the Mardivirus genus. Primary avian somatic cells are currently used for virus replication and vaccine production, but they are largely refractory to any genetic modification compatible with the preservation of intact viral susceptibility. We explored the concept of induction of viral replication permissiveness in an established pluripotent chicken embryonic stem cell-line (cES) in order to derive a new fully susceptible cell-line...
2017: PloS One
https://www.readbyqxmd.com/read/28381111/spontaneous-spinal-plexiform-perineurioma-in-a-juvenile-chicken-gallus-domesticus
#19
Lara Cusack, Uriel Blas-Machado, Joerg Mayer
A 2-mo-old pet chicken ( Gallus domesticus) was presented because of lameness and a hind limb mass of 1 mo duration. Radiographs revealed a soft tissue mass extending from the mid-femur into the body wall. Cytology of a sample obtained from a fine-needle aspirate was unremarkable. The bird was prepared for surgical investigation of the mass but died acutely at the time of pre-medication. Autopsy revealed an extradural mesenchymal neoplasm that focally compressed the lumbar spinal cord, extended into and along the adjacent nerve structures, and displaced the kidneys, skeletal muscle, and body wall...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28368367/a-chinese-variant-marek-s-disease-virus-strain-with-divergence-between-virulence-and-vaccine-resistance
#20
Guo-Rong Sun, Yan-Ping Zhang, Hong-Chao Lv, Lin-Yi Zhou, Hong-Yu Cui, Yu-Long Gao, Xiao-le Qi, Yong-Qiang Wang, Kai Li, Li Gao, Qing Pan, Xiao-Mei Wang, Chang-Jun Liu
Marek's disease (MD) virus (MDV) has been evolving continuously, leading to increasing vaccination failure. Here, the MDV field strain BS/15 was isolated from a severely diseased Chinese chicken flock previously vaccinated with CVI988. To explore the causes of vaccination failure, specific-pathogen free (SPF) chickens vaccinated with CVI988 or 814 and unvaccinated controls were challenged with either BS/15 or the reference strain Md5. Both strains induced MD lesions in unvaccinated chickens with similar mortality rates of 85...
April 3, 2017: Viruses
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