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Marek's disease virus

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https://www.readbyqxmd.com/read/29091922/characterization-of-the-deubiquitination-activity-and-substrate-specificity-of-the-chicken-ubiquitin-specific-protease-1-usp-associated-factor-1-complex
#1
Hainan Zheng, Mengyun Wang, Chengcheng Zhao, Shanli Wu, Peifeng Yu, Yan Lü, Tiedong Wang, Yongxing Ai
Deubiquitinases (DUBs) are essential regulators of intracellular processes involving ubiquitin (Ub) modification. The human DUB ubiquitin-specific protease 1 (hUSP1) interacts with human USP-associated factor 1 (hUAF1), and helps to regulate processes such as DNA damage repair. Previously, we identified a chicken USP1 homologue (chUSP1) during an investigation into the properties of Marek's disease virus (MDV). However, chUSP1's deubiquitination activity, interaction with chUAF1, and substrate specificity remained unknown...
2017: PloS One
https://www.readbyqxmd.com/read/29077674/macrophage-activation-and-the-tumor-necrosis-factor-cascade-in-hepatitis-c-disease-progression-among-hiv-infected-women-participating-in-the-women-s-interagency-hiv-study
#2
Audrey L French, Jonathan W Martin, Charlesnika T Evans, Marion Peters, Seble G Kessaye, Marek Nowicki, Mark Kuniholm, Elizabeth Golub, Michael Augenbraun, Seema N Desai
BACKGROUND: HIV/hepatitis C-coinfected persons experience more rapid liver disease progression than hepatitis C virus (HCV) monoinfected persons, even in the setting of potent antiretroviral therapy. METHODS: We sought to articulate the role of macrophage activation and inflammation in liver disease progression by measuring serial soluble markers in HIV/HCV-coinfected women. We compared markers measured during retrospectively defined periods of rapid liver disease progression to periods where little or no liver disease progression occurred...
December 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29061957/negative-correlation-between-hepatitis-c-virus-hcv-and-let-7-microrna-family-in-transplanted-livers-the-role-of-rs868-single-nucleotide-polymorphism
#3
Emir Ahmed Sajjad, Marek Radkowski, Agnieszka Perkowska-Ptasińska, Marek Pacholczyk, Magdalena Durlik, Mikołaj Fedorowicz, Renata Pietrzak, Bogna Ziarkiewicz-Wróblewska, Paweł Włodarski, Jacek Malejczyk
BACKGROUND Genetic alterations of TGF-β pathway members, including its transmembrane receptor, TGFBR1, may influence the course of HCV infection. Rs868 is a single-nucleotide polymorphism of the 3'UTR region of TGFBR1, located in a binding site for the conserved let-7/miR98 microRNA family. Previously, we demonstrated a favorable course of hepatitis C recurrence after liver transplantation in rs868 AG genotype of the transplanted liver when compared to rs868 AA. The aim of the present study was to confirm the biological effect of rs868...
October 24, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29054826/viral-infections-in-common-carp-lead-to-a-disturbance-of-mucin-expression-in-mucosal-tissues
#4
Mikolaj Adamek, Dennis Hazerli, Marek Matras, Felix Teitge, Michal Reichert, Dieter Steinhagen
In response to the constant challenge by potential pathogens, external surfaces of fish, their skin, gills and intestinal tract, are coated with mucus, a gel like substance which largely prevents the entry of pathogens. This mucus gel consists mainly of water and mucins, large O-glycosylated proteins, which are responsible for forming a gel like mixture. A modulation of the mRNA expression of mucins, was described in viral diseases in mammals however there is a knowledge gap about the regulation of mucins during viral infection in fish...
October 17, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29050325/toll-like-receptor-3-pathway-restricts-marek-s-disease-virus-infection
#5
Haitao Zou, Ruixue Su, Jing Ruan, Hongxia Shao, Kun Qian, Jianqiang Ye, Aijian Qin
Marek's disease virus (MDV) is an α-herpesvirus that causes immune suppression and T lymphoma in chickens. Toll-like receptor 3 (TLR3) is critical for the host immune response against MDV infection. Previously, our team demonstrated that pre-treatment of TLR3 agonist poly (I:C) inhibited Marek's disease virus infection in chicken embryo fibroblasts (CEFs). However, whether TLR3 inhibits the aggravation of MDV infection is unknown. In the current study, we found that TLR3 activation in MDV-infected CEFs effectively inhibited virus spread...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29021518/the-lethal-spanish-influenza-pandemic-in-poland
#6
Marek L Grabowski, Bożena Kosińska, Józef P Knap, Lidia B Brydak
The Spanish influenza pandemic in the years 1918-1920 was the largest and most tragic pandemic of infectious disease in human history. Deciphering the structure of the virus (including the determination of complete genome sequence) of this pandemic and the phylogenetic analysis and explanation of its virulence became possible thanks to molecular genetic analysis of the virus isolated from the fixed and frozen lung tissue of influenza victims who died in 1918 and were buried frozen in Alaska and Spitsbergen...
October 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29018431/depression-of-vaccinal-immunity-to-marek-s-disease-by-infection-with-chicken-infectious-anemia-virus
#7
Yankun Zhang, Ning Cui, Ni Han, Jiayan Wu, Zhizhong Cui, Shuai Su
Marek's disease (MD) has been occurring with increasing frequency in chickens in recent years. To our knowledge, however, there has been no report of the very virulent plus (vv+) MD virus (MDV) field isolate in China. Studies have shown that dual infection with immunosuppressive viruses such as chicken infectious anemia virus (CIAV) occurs frequently in chickens developing MD. In this study, we performed a designed set of in vivo experiments, which comprised five different groups of chickens, including the group of CVI988/Rispens-vaccinated chickens, the groups of CVI988/Rispens-vaccinated chickens infected with MDV or CIAV or both viruses (MDV and CIAV), and the group of MDV-challenged chickens...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28978699/induction-of-dna-damages-upon-marek-s-disease-virus-infection-implication-in-viral-replication-and-pathogenesis
#8
Djihad Bencherit, Sylvie Remy, Yves Le Vern, Tereza Vychodil, Luca D Bertzbach, Benedikt B Kaufer, Caroline Denesvre, Laëtitia Trapp-Fragnet
Marek's disease virus (MDV) is a highly contagious alphaherpesvirus that infects chickens and causes a deadly neoplastic disease. We previously demonstrated that MDV infection arrests cells in S-phase and that the tegument protein VP22 plays a major role in this process. In addition, expression of VP22 induces double strand breaks (DSB) in the cellular DNA, suggesting that DNA damage and the associated cellular response might be favorable for the MDV lifecycle. Here, we addressed the role of DNA damage in MDV replication and pathogenesis...
October 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28954472/comparative-molecular-analysis-of-strains-of-the-aleutian-disease-virus-isolated-from-farmed-and-wild-mink
#9
Andrzej Jakubczak, Marek Kowalczyk, Krzysztof Kostro, Grazyna Jezewska-Witkowska
INTRODUCTION AND OBJECTIVE: Aleutian Disease is a significant biological factor causing substantial losses in mink farming. The virus inducing the disease also infects wild populations which may constitute an asymptomatic reservoir. To compare genetic variants of the AMD virus occurring in wild and farmed mink populations, an analysis was performed on a fragment of the VP2 protein sequence of the virus infecting both populations, taken from different living environments. MATERIAL AND METHODS: Genetic material was isolated from 11 farmed animals in which anti-AMDV antibodies had been detected and from 20 wild animals...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28930088/comparison-of-pcr-methods-for-the-detection-of-genetic-variants-of-carp-edema-virus
#10
Mikolaj Adamek, Marek Matras, Verena Jung-Schroers, Felix Teitge, Max Heling, Sven M Bergmann, Michal Reichert, Keith Way, David M Stone, Dieter Steinhagen
The infection of common carp and its ornamental variety, koi, with the carp edema virus (CEV) is often associated with the occurrence of a clinical disease called 'koi sleepy disease'. The disease may lead to high mortality in both koi and common carp populations. To prevent further spread of the infection and the disease, a reliable detection method for this virus is required. However, the high genetic variability of the CEV p4a gene used for PCR-based diagnostics could be a serious obstacle for successful and reliable detection of virus infection in field samples...
September 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28910208/immunohistochemical-and-immunocytochemical-findings-associated-with-marek-s-disease-virus-in-naturally-infected-laying-hens
#11
O Yavuz, H Erer
We compared immunohistochemical (IHC) staining of tissue sections of liver, kidney, spleen, lung, proventriculus, sciatic nerve, bursa of Fabricius, brain, heart, intestine and skin; immunocytochemical (ICC) staining of peripheral blood samples and touch preparations of liver, spleen and kidney of laying hens naturally infected with Marek's disease (MD) virus. We used one hundred and fifty 5-17-week-old commercial hens. IHC and ICC staining were performed using polymer-based techniques. IHC staining exhibited mostly free immunopositive reactions in tumor cells and in the cytoplasm of the parenchymal cells of liver, kidney, spleen and bursa of Fabricius...
September 14, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28860661/long-intergenic-non-coding-rna-galmd3-in-chicken-marek-s-disease
#12
Bo Han, Yanghua He, Li Zhang, Yi Ding, Ling Lian, Chunfang Zhao, Jiuzhou Song, Ning Yang
Long intergenic non-coding RNAs (lincRNAs) are transcribed from non-coding DNA sequences. Studies have revealed that aberrant expressions of lincRNAs are associated with various types of cancers and neurological disorders. Marek's disease (MD) is a highly contagious T-cell lymphoid neoplasia of chicken induced by Marek's disease virus (MDV). In this study, we first identified and validated linc-GALMD3 highly expressed in MDV-infected CD4+ T cells by RNA-Seq and qRT-PCR. By RNA-Seq analysis in MDCC-MSB1 cells after loss of function of linc-GALMD3 by shRNA, we found that linc-GALMD3 could positively cis-regulate its downstream gga-miR-223 gene expression...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28859493/characterizing-the-histopathology-of-natural-co-infection-with-marek-s-disease-virus-and-subgroup-j-avian-leukosis-virus-in-egg-laying-hens
#13
Yawen Wen, Qi Huang, Chengcheng Yang, Ling Pan, Guijun Wang, Kezong Qi, Hongmei Liu
Marek's disease virus (MDV) and avian leukosis virus (ALV) are known to cause tumours in egg-laying hens. Here, we investigated the aetiology of tumours in a flock of egg-laying hens vaccinated against MDV. We carried out gross pathology and histopathological examinations of the diseased tissues, identified virus antigen and sequenced viral oncogenes to elucidate the cause of death in 21-22-wk-old hens. At necropsy, diseased hens had distinctly swollen livers, spleens, and proventriculus, and white tumour nodules in the liver...
September 1, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28819105/a-novel-method-for-genome-wide-profiling-of-dynamic-host-pathogen-interactions-using-3-end-enriched-rna-seq
#14
Jie Li, Liangliang He, Yun Zhang, Chunyi Xue, Yongchang Cao
Marek's disease is a contagious lymphoproliferative disease of chickens and typical model of viral oncogenesis. Mapping changes or different states over the course of infection for both host and pathogen would provide important insights into dynamic host-pathogen interactions. Here we introduced 3' end enriched RNA-seq as a novel method to study host-pathogen interactions in chicken embryo fibroblasts cells challenged with Marek's disease virus. The method allowed accurate profiling of gene expression and alternative polyadenylation sites for host and pathogen simultaneously...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28812393/innate-lymphoid-cells-the-role-in-respiratory-infections-and-lung-tissue-damage
#15
Anna Głobińska, Marek L Kowalski
Innate lymphoid cells (ILCs) represent a diverse family of cells of the innate immune system, which play an important role in regulation of tissue homeostasis, immunity and inflammation. Emerging evidence has highlighted the importance of ILCs in both protective immunity to respiratory infections and their pathological roles in the lungs. Therefore, the aim of this review is to summarize the current knowledge, interpret and integrate it into broader perspective, enabling greater insight into the role of ILCs in respiratory diseases...
October 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28804982/epidemiological-investigation-of-outbreaks-of-fowl-adenovirus-infections-in-commercial-chickens-in-china
#16
Y Niu, Q Sun, G Zhang, W Sun, X Liu, Y Xiao, Y Shang, S Liu
One hundred and five fowl adenovirus (FAdV) strains were isolated in China from 2015 to 2016 from poultry with inclusion body hepatitis (IBH) and hydropericardium syndrome (HPS). Polymerase chain reactions determined that 68 were FAdV species C, five were FAdV species D, two were FAdV species E, and 30 contained two or more different FAdV strains. A phylogenetic analysis showed that the isolated FAdV strains clustered into three major groups: FAdV-C, FAdV-D and FAdV-E. Based on a hexon gene sequencing analysis, these viruses were genetically related to FAdV-4, FAdV-7, FAdV-8b and FAdV-11, of which FAdV-4 was dominant (93% of the strains)...
August 13, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28762757/molecular-characterization-and-phylogenetic-analysis-of-virulent-marek-s-disease-virus-field-strain-in-broiler-chickens-in-japan
#17
Hoda A Abd-Ellatieff, Abdelrahman A Abou Rawash, Hany F Ellakany, Wael M Goda, T Suzuki, Tokuma Yanai
Marek's disease (MD) is a lymphoproliferative disease causing a serious threat in poultry production. Field strains of Marek's disease virus (MDVs) are continuously re-emerging, causing great economical losses to the poultry industry worldwide in spite of the intensive vaccination and restrictive management policy used. Histopathological and molecular characterizations of MDVs are essential for monitoring the changes of viruses and evaluating the effectiveness of existing vaccines. During 2016, 190 visceral tumor tissues representing 30 vaccinated chicken flocks from Gifu prefecture, Japan were analyzed...
August 1, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28757026/marek-s-disease-virus-type-1-encoded-analog-of-mir-155-promotes-proliferation-of-chicken-embryo-fibroblast-and-df-1-cells-by-targeting-hnrnpab
#18
Lu Dang, Man Teng, Hui-Zhen Li, Sheng-Ming Ma, Qing-Xia Lu, Hui-Fang Hao, Dong Zhao, En-Min Zhou, Gai-Ping Zhang, Jun Luo
Marek's disease virus type 1 (MDV-1) is a representative oncogenic Alpha herpesvirus that causes an immunosuppressive and neoplastic lymphoproliferative avian disease, namely Marek's disease (MD). The rapid-onset T-cell lymphoma in chickens induced by MDV-1 has been historically regarded as an ideal natural model for herpesvirus-related cancer research. As a viral analog of cellular miR-155, the MDV-1-encoded miR-M4-5p has been shown to be crucial for the virally-induced MD tumorigenesis. Our previous studies demonstrated that miR-M4-5p induces an over-expression of oncogene c-Myc by targeting LTBP1 and suppressing the TGF-β signaling pathway during MDV-1 infection...
August 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28754487/recombinant-gallid-herpesvirus-2-with-interrupted-meq-genes-confers-safe-and-efficacious-protection-against-virulent-field-strains
#19
Yanping Zhang, Changjun Liu, Fuhai Yan, Ailing Liu, Yun Cheng, Zhijie Li, Guorong Sun, Hongchao Lv, Xiaomei Wang
Gallid herpesvirus 2 (GaHV-2) continuously evolves, which reduces the effectiveness of existing vaccines. To construct new GaHV-2 candidate vaccines, LMS, which is a virulent GaHV-2 field strain isolated from diseased chicken flocks in Southwest China in 2007, was modified such that both copies of its meq oncogene were partially deleted. The resulting virus, i.e., rMSΔmeq, was characterized using PCR and sequencing. To evaluate the safety and protective efficacy of rMSΔmeq, specific pathogen-free (SPF) chickens were inoculated with 2000 plaque forming units (pfu) and 20,000pfu of rMSΔmeq immediately after hatching...
July 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28694799/a-tiny-rna-that-packs-a-big-punch-the-critical-role-of-a-viral-mir-155-ortholog-in-lymphomagenesis-in-marek-s-disease
#20
REVIEW
Guoqing Zhuang, Aijun Sun, Man Teng, Jun Luo
MicroRNAs (miRNAs) are small non-coding RNAs that have been identified in animals, plants, and viruses. These small RNAs play important roles in post-transcriptional regulation of various cellular processes, including development, differentiation, and all aspects of cancer biology. Rapid-onset T-cell lymphoma of chickens, namely Marek's disease (MD), induced by Gallid alphaherpesvirus 2 (GaHV2), could provide an ideal natural animal model for herpesvirus-related cancer research. GaHV2 encodes 26 mature miRNAs derived from 14 precursors assembled in three distinct gene clusters in the viral genome...
2017: Frontiers in Microbiology
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