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levetiracetam and hippocampal volume

Huichao Zou, Max Hurwitz, Lorraine Fowler, Amy K Wagner
OBJECTIVE: Long-term prophylactic treatment with levetiracetam (LEV) has multiple neuroprotective effects in a traumatic brain injury (TBI) rat model. Although a rational time-frame of seizure prophylactic treatment with LEV for after TBI is not well established, clinical prophylaxis with LEV often includes treatment duration similar to clinical treatment guidelines with Phenytoin. Thus, this study investigated the effects of abbreviated LEV treatment on behavioural function and histological evidence of neuroprotection...
2015: Brain Injury: [BI]
Huichao Zou, Samuel W Brayer, Maxwell Hurwitz, Christian Niyonkuru, Lorraine E Fowler, Amy K Wagner
BACKGROUND: Prophylactic treatment with antiepileptic drugs (AEDs) has been recommended to prevent early seizure onset in patients with traumatic brain injury (TBI). However, the potential neuroprotective and/or detrimental effects of prophylactic AED treatment on behavioral and cognitive function after TBI are not well studied. OBJECTIVE: To investigate the effects of a novel AED, levitiracetam (LEV), on behavioral and cognitive function after experimental TBI in rats...
November 2013: Neurorehabilitation and Neural Repair
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