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https://www.readbyqxmd.com/read/29454235/donor-and-recipient-p450-gene-polymorphisms-influence-individual-pharmacological-effects-of-tacrolimus-in-chinese-liver-transplantation-patients
#1
Jianyu Liu, Yabo Ouyang, Dexi Chen, Bo Yao, Dongdong Lin, Zhiqiang Li, Yunjin Zang, Huan Liu, Xiaoyue Fu
The immunosuppressant drug tacrolimus (Tac) used for the prevention of immunological rejection is a metabolic substrate of cytochrome P450 enzymes. This study was designed to evaluate the short-term and long-term potential influence of single-nucleotide polymorphisms (SNPs) in CYP450 genes of liver transplant (LT) recipients as well as the donors on individual pharmacological effects of Tac and to guide individualized-medication from the perspective of pharmacogenomics. Twenty-one SNPs of the CYP450 gene were genotyped for both recipients and donors in 373 LT patients receiving Tac-based immunosuppressants...
February 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29453340/elevated-nitrogen-allows-the-weak-invasive-plant-galinsoga-quadriradiata-to-become-more-vigorous-with-respect-to-inter-specific-competition
#2
Gang Liu, Ying-Bo Yang, Zhi-Hong Zhu
Elevated nitrogen associated with global change is believed to promote the invasion of many vigorous exotic plants. However, it is unclear how a weak exotic plant will respond to elevated nitrogen in the future. In this study, the competitive outcome of a weak invasive plant (Galinsoga quadriradiata) and two non-invasive plants was detected. The plants were subjected to 3 types of culture (mixed, monoculture or one-plant), 2 levels of nitrogen (ambient or elevated at a rate of 2 g m -2 yr -1 ) and 2 levels of light (65% shade or full sunlight)...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29452418/phf20-collaborates-with-parp1-to-promote-stemness-and-aggressiveness-of-neuroblastoma-cells-through-activation-of-sox2-and-oct4
#3
Wenyong Long, Wei Zhao, Bo Ning, Jing Huang, Junjun Chu, Linfeng Li, Qianquan Ma, Changsheng Xing, Helen Y Wang, Qing Liu, Rong-Fu Wang
The differentiation status of neuroblastoma (NB) strongly correlates with its clinical outcomes; however, the molecular mechanisms driving maintenance of stemness and differentiation remain poorly understood. Here, we show that plant homeodomain finger-containing protein 20 (PHF20) functions as a critical epigenetic regulator in sustaining stem cell-like phenotype of NB by using CRISPR/Cas9-based targeted knockout (KO) for high-throughput screening of gene function in NB cell differentiation. Expression of PHF20 in NB was significantly associated with high aggressiveness of the tumor and poor outcomes for NB patients...
February 14, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29451872/differences-in-neural-responses-to-ipsilateral-stimuli-in-wide-view-fields-between-face-and-house-selective-areas
#4
Bin Wang, Ting Li, Yan Niu, Jie Xiang, Junjie Cheng, Bo Liu, Hui Zhang, Tianyi Yan, Susumu Kanazawa, Jinglong Wu
Category-selective brain areas exhibit varying levels of neural activity to ipsilaterally presented stimuli. However, in face- and house-selective areas, the neural responses evoked by ipsilateral stimuli in the peripheral visual field remain unclear. In this study, we displayed face and house images using a wide-view visual presentation system while performing functional magnetic resonance imaging (fMRI). The face-selective areas (fusiform face area (FFA) and occipital face area (OFA)) exhibited intense neural responses to ipsilaterally presented images, whereas the house-selective areas (parahippocampal place area (PPA) and transverse occipital sulcus (TOS)) exhibited substantially smaller and even negative neural responses to the ipsilaterally presented images...
2018: PloS One
https://www.readbyqxmd.com/read/29449934/a-thin-multifunctional-coating-on-a-separator-improves-the-cyclability-and-safety-of-lithium-sulfur-batteries
#5
Guiyin Xu, Qing-Bo Yan, Shitong Wang, Akihiro Kushima, Peng Bai, Kai Liu, Xiaogang Zhang, Zilong Tang, Ju Li
Lithium-sulfur batteries are one of the most promising next-generation batteries due to their high theoretical specific capacity, but are impeded by the low utilization of insulating sulfur, unstable morphology of the lithium metal anode, and transport of soluble polysulfides. Here, by coating a layer of nano titanium dioxide and carbon black onto a commercial polypropylene separator, we demonstrate a new composite separator that can confine the polysulfides on the cathode side, forming a catholyte chamber, and at the same time block the dendritic lithium on the anode side...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29449644/inhibition-of-the-jnk-mapk-signaling-pathway-by-myogenesis-associated-mirnas-is-required-for-skeletal-muscle-development
#6
Shu-Juan Xie, Jun-Hao Li, Hua-Feng Chen, Ye-Ya Tan, Shu-Rong Liu, Yin Zhang, Hui Xu, Jian-Hua Yang, Shun Liu, Ling-Ling Zheng, Mian-Bo Huang, Yan-Hua Guo, Qi Zhang, Hui Zhou, Liang-Hu Qu
Skeletal muscle differentiation is controlled by multiple cell signaling pathways, however, the JNK/MAPK signaling pathway dominating this process has not been fully elucidated. Here, we report that the JNK/MAPK pathway was significantly downregulated in the late stages of myogenesis, and in contrast to P38/MAPK pathway, it negatively regulated skeletal muscle differentiation. Based on the PAR-CLIP-seq analysis, we identified six elevated miRNAs (miR-1a-3p, miR-133a-3p, miR-133b-3p, miR-206-3p, miR-128-3p, miR-351-5p), namely myogenesis-associated miRNAs (mamiRs), negatively controlled the JNK/MAPK pathway by repressing multiple factors for the phosphorylation of the JNK/MAPK pathway, including MEKK1, MEKK2, MKK7, and c-Jun but not JNK protein itself, and as a result, expression of transcriptional factor MyoD and mamiRs were further promoted...
February 15, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29449621/polygonum-aviculare-l-extract-and-quercetin-attenuate-contraction-in-airway-smooth-muscle
#7
Xi Luo, Lu Xue, Hao Xu, Qing-Yang Zhao, Qian Wang, Yu-Shan She, Dun-An Zang, Jinhua Shen, Yong-Bo Peng, Ping Zhao, Meng-Fei Yu, Weiwei Chen, Li-Qun Ma, Shu Chen, Shanshan Chen, Xiangning Fu, Sheng Hu, Xiaowei Nie, Chenyou Shen, Chunbin Zou, Gangjian Qin, Jiapei Dai, Guangju Ji, Yunchao Su, Shen Hu, Jingyu Chen, Qing-Hua Liu
Because of the serious side effects of the currently used bronchodilators, new compounds with similar functions must be developed. We screened several herbs and found that Polygonum aviculare L. contains ingredients that inhibit the precontraction of mouse and human airway smooth muscle (ASM). High K + -induced precontraction in ASM was completely inhibited by nifedipine, a selective blocker of L-type voltage-dependent Ca 2+ channels (LVDCCs). However, nifedipine only partially reduced the precontraction induced by acetylcholine chloride (ACH)...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449555/intravenous-injections-of-the-oncolytic-virus-m1-as-a-novel-therapy-for-muscle-invasive-bladder-cancer
#8
Cheng Hu, Ying Liu, Yuan Lin, Jian-Kai Liang, Wen-Wen Zhong, Ke Li, Wen-Tao Huang, De-Juan Wang, Guang-Mei Yan, Wen-Bo Zhu, Jian-Guang Qiu, Xin Gao
Muscle-invasive bladder cancer (MIBC) is associated with low survival and high recurrence rates even in cases in which patients receive systemic treatments, such as surgery and chemotherapy. Here, we found that a naturally existing alphavirus, namely, M1, selectively kills bladder cancer cells but not normal cells, findings supported by our observations of changes in viral replication and MIBC and patient-derived MIBC cell apoptosis. Transcriptome analysis revealed that interferon-stimulated genes (ISGs) are expressed at low levels in sensitive bladder cancer cells and high levels in resistant cells...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29449294/disease-characteristics-and-management-of-hospitalised-adolescents-and-adults-with-community-acquired-pneumonia-in-china-a-retrospective-multicentre-survey
#9
Liang Chen, Fei Zhou, Hui Li, Xiqian Xing, Xiudi Han, Yiming Wang, Chunxiao Zhang, Lijun Suo, Jingxiang Wang, Guohua Yu, Guangqiang Wang, Xuexin Yao, Hongxia Yu, Lei Wang, Meng Liu, Chunxue Xue, Bo Liu, Xiaoli Zhu, Yanli Li, Ying Xiao, Xiaojing Cui, Lijuan Li, Timothy M Uyeki, Chen Wang, Bin Cao
OBJECTIVES: To describe the clinical characteristics and management of patients hospitalised with community-acquired pneumonia (CAP) in China. DESIGN: This was a multicentre, retrospective, observational study. SETTING: 13 teaching hospitals in northern, central and southern China from 1 January 2014 to 31 December 2014 PARTICIPANTS: Information on hospitalised patients aged ≥14 years with radiographically confirmed pneumonia with illness onset in the community was collected using standard case report forms...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29448661/study-on-sand-erosion-and-tribological-behavior-of-tio%C3%A2-films-prepared-on-a-glass-surface
#10
Bo Zhang, Junzhong Wang, Zhiming Shi, Quansheng Liu, Guojun Ji
TiO2 films with one, three or five layers were prepared on a glass surface using the sol-gel method. The crystal structure, the surface morphology and the thickness of the films were characterized by X-ray diffraction, atomic force microscopy and ellipsometry. The tribological properties of the TiO2 films were investigated by a tribometer. TiO2 thin films were eroded by sand-air injection. The erosion behavior and mechanism of TiO2 thin films in a sandstorm were analyzed by scanning electron microscopy. The results showed that the films were highly abraded with increased erosion speed and dose of sand...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447479/two-new-lignans-from-horsfieldia-kingii
#11
Bo Liu, Shou-Zhen Du, Fang Kuang, Ying Liu, Xing-Jun Tian, Ye-Gao Chen, Rui Zhan
Two new dibenzylbutyrolactol lignans and three known dibenzylbutyrolactone lignans were isolated from the twigs and leaves of Horsfieldia kingii. Their structures were elucidated by spectroscopic analysis. Cytotoxicity evaluation of these compounds against five human tumour lines showed no inhibitory effects.
February 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29446867/epigallocatechin-gallate-reduces-amyloid-%C3%AE-induced-neurotoxicity-via-inhibiting-endoplasmic-reticulum-stress-mediated-apoptosis
#12
Ke Du, Mingyan Liu, Xin Zhong, Weifan Yao, Qinghuan Xiao, Quan Wen, Bo Yang, Minjie Wei
SCOPE: We investigated the role of endoplasmic reticulum (ER) stress in the protective effects of EGCG against the neuronal apoptosis in Aβ 1-42 -induced SH-SY5Y cells and APP/PS1 transgenic mice. METHODS AND RESULTS: Cell viability (CCK8 assay), flow cytometry, Hoechst 33258 staining, immunohistochemistry, Transmission Electron Microscopy (TEM), western blotting were used. EGCG prevented Aβ1-42-induced toxicity in SH-SY5Y cells, increased cell viability and decreased apoptosis in a dose-dependent manner...
February 15, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29446856/thyroid-carcinoma-producing-%C3%AE-human-chorionic-gonadotropin-shows-different-clinical-behavior
#13
Haiyan Gu, Shaofeng Sui, Xiujie Cui, Bo Han, Chunyan Zhang, Mei Qi, Congcong Li, Zhiyan Liu
Columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is an unusual neoplasm, the clinical behavior of which mainly depends on the encapsulation or infiltration. Patients with extensive extrathyroidal extension usually have an aggressive biological behavior. This study confirmed that beta-human chorionic gonadotropin (β-hCG) secreting invasive CCV-PTC has good prognosis comparing with a cohort of follicular cell differentiated thyroid carcinoma. On the contrary, positive immunoreaction with β-hCG was proved in three anaplastic thyroid carcinoma patients showing aggressive clinical courses...
February 15, 2018: Pathology International
https://www.readbyqxmd.com/read/29446735/epigenetic-regulation-of-regulatory-t-cells-in-kidney-disease-and-transplantation
#14
Yufeng Liu, Bo Peng, Shengdi Wu, Nuo Xu
Regulatory T (Treg) cells are a kind of immunosuppression cells, which have been used to treat autoimmune diseases and induce allograft tolerance in clinical trials. While Treg cells based therapy is a promising treatment for kidney diseases and an emerging concept for tolerance induction in renal transplantation, a better understanding of the functions and biology of Treg cells is needed to be able to optimally exploit them. Epigenetics regulation, which refers to potentially heritable alterations in gene expression without underlying changes of the nucleotide sequence, plays an important role in Treg cells induction and maintenance...
February 13, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/29445189/stk17b-promotes-carcinogenesis-and-metastasis-via-akt-gsk-3%C3%AE-snail-signaling-in-hepatocellular-carcinoma
#15
Yaliang Lan, Jihua Han, Yan Wang, Jiabei Wang, Guangchao Yang, Keyu Li, Ruipeng Song, Tongsen Zheng, Yingjian Liang, Shangha Pan, Xirui Liu, Mingxi Zhu, Yao Liu, Fanzheng Meng, Manzoor Mohsin, Yifeng Cui, Bo Zhang, Sharma Subash, Lianxin Liu
Hepatocellular carcinoma (HCC) is a lethal malignancy worldwide with frequent intrahepatic and distant metastasis. Elucidating the underlying molecular mechanism that modulates HCC progression is critical for exploring novel therapeutic strategies. Serine/Threonine Kinase 17B (STK17B) is upregulated in HCC tissues, but its role in HCC progression remains elusive. In the present studies, we reported that STK17B had a critical role in HCC progression. STK17B was significantly upregulated in HCC cell lines and specimens, and patients with ectopic STK17B expression characterized with poor clinicopathological features...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29445144/lenalidomide-regulates-cns-autoimmunity-by-promoting-m2-macrophages-polarization
#16
Qinjie Weng, Jiaying Wang, Jiajia Wang, Jing Wang, Fahmida Sattar, Zhikang Zhang, Jiahuan Zheng, Zijie Xu, Mengting Zhao, Xuan Liu, Lijun Yang, Guifeng Hao, Liang Fang, Q Richard Lu, Bo Yang, Qiaojun He
Multiple sclerosis (MS) is a chronic and debilitating neurological disorder of the central nervous system (CNS), characterized by infiltration of leukocytes into CNS and subsequent demyelination. Emerging evidences have revealed the beneficial roles of M2 macrophages in ameliorating experimental autoimmune encephalomyelitis (EAE), a model for MS. Here, we identify that lenalidomide alone could promote macrophages M2 polarization to prevent the progression of EAE, which is associated with subsequent inhibition of proinflammatory Th1 and Th17 cells both in peripheral lymph system and CNS...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29445087/rage-induces-hepatocellular-carcinoma-proliferation-and-sorafenib-resistance-by-modulating-autophagy
#17
Jun Li, Peng-Wen Wu, Yuan Zhou, Bo Dai, Peng-Fei Zhang, Yu-Hen Zhang, Yang Liu, Xiao-Lei Shi
The receptor for advanced glycation end products (Rage) is involved in the development of various tumors and acts as an oncogenic protein. Rage is overexpressed in tumors including hepatocellular carcinoma (HCC). However, the molecular mechanism of Rage in HCC progression and sorafenib resistance remains unclear. In this study, enhanced Rage expression is highly associated proliferation and contributes to sorafenib resistance. Rage deficiency contributed to autophagy induction through activating AMPK/mTOR signaling pathway, which is important for sorafenib response...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29444597/an-experimental-model-for-hypertensive-crises-emergencies-long-term-high-fat-diet-followed-by-acute-vasoconstriction-stress-on-spontaneously-hypertensive-rats
#18
Hong Liu, Wei-Wei Su, Chao-Feng Long, Wei-Jian Zhang, Pei-Bo Li, Zhong Wu, Yin-Yin Liao, Xuan Zeng, Tao-Bin Chen, Yu-Ying Zheng, Zeng-Hao Yan, Cong Bi, Hong-Liang Yao
Currently, the prevention and treatment of hypertensive crises especially when it occurs with serious adverse outcomes have led to worldwide controversy. Despite of clinical possibilities of multiple agents, clinical failures still occur frequently. Therefore, early evaluations and observations of different therapies on appropriate animals should be emphasized. In the present study, an animal model for hypertensive crises emergencies was firstly established and experimentally testified. Five-month-male spontaneously hypertensive rat was consecutively fed with 60%-Kcal fat diet for four, six, and eight weeks with body weight and blood pressure monitored every two weeks, and then followed by an acute vasoconstriction stress of 5-min ice-bath treatment in the 4-h time interval of two adrenaline injections (0...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29443734/prognostic-significance-of-pulmonary-hypertension-in-patients-with-cystic-fibrosis-a-systematic-review-and-meta-analysis
#19
Diandian Li, Bo Wang, Hao Wang, Qun Liu
BACKGROUND AND OBJECTIVE: Pulmonary hypertension (PH) is frequently found in advanced parenchymal lung diseases like cystic fibrosis (CF), but the role played by PH in the clinical outcome of CF patients remains unclear. The aim of this study is to determine the influence of PH on survival in the CF population by meta-analysis. METHODS: Publications addressing the associations between PH and overall survival (OS) or other clinical characteristics in CF patients were selected from electronic databases...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29442026/upregulation-of-p63-inhibits-chondrocyte-autophagy-thereby-enhancing-the-malignant-progression-of-osteoarthritis
#20
Yufan Wangyang, Xin Zheng, Guang-Wang Liu, Dong-Ya Li, Yan-Bo Feng, Tong-Ya Guo, Chao Ma, Tao Wang
Loss of autophagy is suggested to play a key role in the progression of osteoarthritis (OA). P63 is a member of the P53 family, which is widely dysregulated in various tumors. However, the specific role of P63 in chondrocyte autophagy has never been fully understood. Here, the expression level of P63 in the articular cartilages of OA patients and chondrocytes treated with 3-MA was explored using western blot. Autophagy was determined using transmission electron microscopy and mRFP-GFP-LC3 assay. Fewer autophagic vesicles were identified in the articular cartilages of OA patients compared with that of normal control...
June 1, 2017: Die Pharmazie
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