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https://www.readbyqxmd.com/read/29224018/sulforaphane-treatment-of-stress-urinary-incontinence-via-the-nrf2-are-pathway-in-a-rat-model
#1
Xiang Wan, Chong Liu, Yan-Bo Chen, Meng Gu, Zhi-Kang Cai, Qi Chen, Zhong Wang
BACKGROUND/AIMS: To explore the effect of sulforaphane (SFN) treatment in rats through the induction of Stress Urinary Incontinence (SUI) via the Nrf2-ARE pathway. METHODS: A total of 18 female rats (Sprague-Dawley) were assigned to three groups: a control group, an SUI group, and an SUI+SFN group (six rats per group). Rats in the treatment groups were induced via postpartum vaginal balloon dilation and bilateral ovariectomy. Rats in the SUI+SFN group were treated via intraperitoneal injection once per day for a total of one month...
December 8, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29223886/electrocatalytic-co2-reduction-catalyzed-by-nitrogenase-mofe-and-fefe-proteins
#2
Bo Hu, Derek F Harris, Dennis R Dean, T Leo Liu, Zhi-Yong Yang, Lance C Seefeldt
Nitrogenases catalyze biological dinitrogen (N2) reduction to ammonia (NH3), and also reduce a number of non-physiological substrates, including carbon dioxide (CO2) to formate (HCOO-) and methane (CH4). Three versions of nitrogenase are known (Mo-, V-, and Fe-nitrogenase), each showing different reactivities towards various substrates. Normally, electrons for substrate reduction are delivered by the Fe protein component of nitrogenase, with energy coming from the hydrolysis of 2 ATP to 2 ADP+2 Pi for each electron transferred...
December 5, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29223765/prognostic-role-of-serum-total-cholesterol-and-high-density-lipoprotein-cholesterol-in-cancer-survivors-a-systematic-review-and-meta-analysis
#3
REVIEW
Pingting Zhou, Bo Li, Bin Liu, Tianrui Chen, Jianru Xiao
BACKGROUND: The alterations of lipid profile in cancer has been reported to be associated with cancer development. However, the prognostic value of serum lipid markers level in cancer is currently under debate. Here we performed a meta-analysis to investigate the prognostic significance of serum blood total cholesterol (TC), Triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) for cancer. METHODS: We systematically searched in PubMed and EMBASE for follow-up studies to evaluate the association between blood TC, TG, HDL-C, LDL-C and overall survival (OS) or disease-free survival (DFS) in patients with cancer...
December 6, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29223442/exosomes-derived-from-imatinib-resistant-chronic-myeloid-leukemia-cells-mediate-a-horizontal-transfer-of-drug-resistant-trait-by-delivering-mir-365
#4
Qing-Hua Min, Xiao-Zhong Wang, Jing Zhang, Qing-Gen Chen, Shu-Qi Li, Xiao-Qing Liu, Jing Li, Jing Liu, Wei-Ming Yang, Yu-Huan Jiang, Yan-Mei Xu, Jin Lin, Qiu-Fang Gao, Fan Sun, Lei Zhang, Bo Huang
Chronic myeloid leukemia (CML) is a malignant disorder of hematopoietic stem/progenitor cells. Majority of patients can be effectively treated with tyrosine kinase inhibitors (TKIs) such as imatinib, but a portion of patients will develop drug resistance. Accumulated evidences have identified exosomes in cancer as promoters of tumor progression. Herein, we found that exosomes derived from imatinib resistant CML cells can be internalized into sensitive CML cells and confer drug-resistance traits. We also demonstrated a significant higher level of miR-365 in exosomes derived from drug-resistant CML cells compared with those from sensitive ones using microarray and qRT-PCR...
December 6, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29222020/synthesis-of-protocatechuic-acid-grafted-chitosan-copolymer-structure-characterization-and-in-vitro-neuroprotective-potential
#5
Chao Xu, Shui Guan, Bo Wang, Shuping Wang, Yuxin Wang, Changkai Sun, Xuehu Ma, Tianqing Liu
Excessive free radicals can cause oxidative damage to human tissues, which results in a variety of diseases. Therefore, the development of antioxidant materials is one of the great projects in biomedical field. In this work, antioxidant protocatechuic acid (PCA) monomers were grafted onto chitosan (CS) backbones to develop a PCA grafted chitosan (PCA-g-CS) antioxidant copolymer via the method of free radical-induced grafting reaction. The formation of covalent bonds between PCA and CS were confirmed by FTIR, 1H NMR, XRD and UV-Vis...
December 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29221303/the-society-for-translational-medicine-clinical-practice-guidelines-for-the-postoperative-management-of-chest-tube-for-patients-undergoing-lobectomy
#6
REVIEW
Shugeng Gao, Zhongheng Zhang, Javier Aragón, Alessandro Brunelli, Stephen Cassivi, Ying Chai, Chang Chen, Chun Chen, Gang Chen, Haiquan Chen, Jin-Shing Chen, David Tom Cooke, John B Downs, Pierre-Emmanuel Falcoz, Wentao Fang, Pier Luigi Filosso, Xiangning Fu, Seth D Force, Martínez I Garutti, Diego Gonzalez-Rivas, Dominique Gossot, Henrik Jessen Hansen, Jianxing He, Jie He, Bo Laksáfoss Holbek, Jian Hu, Yunchao Huang, Mohsen Ibrahim, Andrea Imperatori, Mahmoud Ismail, Gening Jiang, Hongjing Jiang, Zhongmin Jiang, Hyun Koo Kim, Danqing Li, Gaofeng Li, Hui Li, Qiang Li, Xiaofei Li, Yin Li, Zhijun Li, Eric Lim, Chia-Chuan Liu, Deruo Liu, Lunxu Liu, Yongyi Liu, Kevin W Lobdell, Haitao Ma, Weimin Mao, Yousheng Mao, Juwei Mou, Calvin Sze Hang Ng, Nuria M Novoa, René H Petersen, Hiroyuki Oizumi, Kostas Papagiannopoulos, Cecilia Pompili, Guibin Qiao, Majed Refai, Gaetano Rocco, Erico Ruffini, Michele Salati, Agathe Seguin-Givelet, Alan Dart Loon Sihoe, Lijie Tan, Qunyou Tan, Tang Tong, Kosmas Tsakiridis, Federico Venuta, Giulia Veronesi, Nestor Villamizar, Haidong Wang, Qun Wang, Ruwen Wang, Shumin Wang, Gavin M Wright, Deyao Xie, Qi Xue, Tao Xue, Lin Xu, Shidong Xu, Songtao Xu, Tiansheng Yan, Fenglei Yu, Zhentao Yu, Chunfang Zhang, Lanjun Zhang, Tao Zhang, Xun Zhang, Xiaojing Zhao, Xuewei Zhao, Xiuyi Zhi, Qinghua Zhou
The Society for Translational Medicine and The Chinese Society for Thoracic and Cardiovascular Surgery conducted a systematic review of the literature in an attempt to improve our understanding in the postoperative management of chest tubes of patients undergoing pulmonary lobectomy. Recommendations were produced and classified based on an internationally accepted GRADE system. The following recommendations were extracted in the present review: (I) chest tubes can be removed safely with daily pleural fluid of up to 450 mL (non-chylous and non-sanguinous), which may reduce chest tube duration and hospital length of stay (2B); (II) in rare instances, e...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221189/novel-direct-ampk-activator-suppresses-non-small-cell-lung-cancer-through-inhibition-of-lipid-metabolism
#7
Xi Chen, Chun Xie, Xing-Xing Fan, Ze-Bo Jiang, Vincent Kam-Wai Wong, Jia-Hui Xu, Xiao-Jun Yao, Liang Liu, Elaine Lai-Han Leung
Drug resistance is becoming an obstacle in anti-cancer therapies. For target-based therapy of lung cancer, gefitinib, as the first generation of tyrosine kinase inhibitors (TKIs), demonstrated good initial response to the non-small cell lung cancer (NSCLC) patients whom harbors epidermal growth factor receptor (EGFR) mutation. However, within one year, additional EGFR mutation occurred, leading to eventual gefitinib-resistance. Therefore, it is urgently to discover novel effective small molecule inhibitors for those patients...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221161/piriform-cortical-glutamatergic-and-gabaergic-neurons-express-coordinated-plasticity-for-whisker-induced-odor-recall
#8
Yahui Liu, Zilong Gao, Changfeng Chen, Bo Wen, Li Huang, Rongjing Ge, Shidi Zhao, Ruichen Fan, Jing Feng, Wei Lu, Liping Wang, Jin-Hui Wang
Neural plasticity occurs in learning and memory. Coordinated plasticity at glutamatergic and GABAergic neurons during memory formation remains elusive, which we investigate in a mouse model of associative learning by cellular imaging and electrophysiology. Paired odor and whisker stimulations lead to whisker-induced olfaction response. In mice that express this cross-modal memory, the neurons in the piriform cortex are recruited to encode newly acquired whisker signal alongside innate odor signal, and their response patterns to these associated signals are different...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221151/collagen-i-promotes-hepatocellular-carcinoma-cell-proliferation-by-regulating-integrin-%C3%AE-1-fak-signaling-pathway-in-nonalcoholic-fatty-liver
#9
Xinglong Zheng, Wenyan Liu, Junxi Xiang, Peng Liu, Mengyun Ke, Bo Wang, Rongqian Wu, Yi Lv
Nonalcoholic fatty liver disease (NAFLD) has become a major risk factor for hepatocellular carcinoma (HCC) worldwide. However, the underlying mechanism remains insufficiently elucidated. The expression of Collagen I, an important component of extracellular matrix (ECM), was increased during the progression from simple steatosis to NASH. The purpose of this study was to investigate the role of Collagen I in NAFLD-related HCC. To study this, the decellularized liver matrix, which preserves the pathological changes of ECM, was prepared from the human fatty liver (FLM) and human normal liver (NLM)...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220729/comparison-of-dynamic-cervical-implant-versus-anterior-cervical-discectomy-and-fusion-for-the-treatment-of-single-level-cervical-degenerative-disc-disease-a-five-year-follow-up
#10
Ce Zhu, Xi Yang, Lei Wang, Bo-Wen Hu, Li-Min Liu, Lin-Nan Wang, Hao Liu, Yue-Ming Song
OBJECTIVE: To compare clinical and radiographic outcomes of dynamic cervical implant(DCI) with anterior cervical discectomy and fusion(ACDF) in the treatment of single-level cervical degenerative disc disease (CDDD) 5 years after surgery. PATIENTS AND METHODS: Forty-three patients with DCI were matched one-to-one with patients with ACDF based on age, gender, and operative segment in this retrospective study. All patients had been followed up for more than 5 years...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29220150/functionalized-eu-iii-based-nanoscale-metal-organic-framework-to-achieve-near-ir-triggered-and-targeted-two-photon-absorption-photodynamic-therapy
#11
Jianguo Jia, Yang Zhang, Min Zheng, Changfu Shan, Huicheng Yan, Wenyu Wu, Xuan Gao, Bo Cheng, Weisheng Liu, Yu Tang
The postsynthetic-modified nanoscale metal-organic framework (NMOF) probes selected as potential drug delivery platforms and photodynamic therapy agents to fulfill the effective and safe treatment of neoplastic diseases have attracted increasing attention recently. Herein, a Eu(III)-based NMOF probe elaborately postsynthetically modified with a β-diketonate two-photon-absorbing (TPA) ligand is rationally designed and further functionalized by assembling the photosensitizer molecule (methylene blue, MB) in the pores and a cyclic peptide targeting motif on the surface of the NMOF, which could achieve highly efficient near-infrared (NIR)-triggered and -targeted photodynamic therapy (PDT)...
December 8, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29219473/two-hierarchy-entanglement-swapping-for-a-linear-optical-quantum-repeater
#12
Ping Xu, Hai-Lin Yong, Luo-Kan Chen, Chang Liu, Tong Xiang, Xing-Can Yao, He Lu, Zheng-Da Li, Nai-Le Liu, Li Li, Tao Yang, Cheng-Zhi Peng, Bo Zhao, Yu-Ao Chen, Jian-Wei Pan
Quantum repeaters play a significant role in achieving long-distance quantum communication. In the past decades, tremendous effort has been devoted towards constructing a quantum repeater. As one of the crucial elements, entanglement has been created in different memory systems via entanglement swapping. The realization of j-hierarchy entanglement swapping, i.e., connecting quantum memory and further extending the communication distance, is important for implementing a practical quantum repeater. Here, we report the first demonstration of a fault-tolerant two-hierarchy entanglement swapping with linear optics using parametric down-conversion sources...
October 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29219368/satellite-to-ground-entanglement-based-quantum-key-distribution
#13
Juan Yin, Yuan Cao, Yu-Huai Li, Ji-Gang Ren, Sheng-Kai Liao, Liang Zhang, Wen-Qi Cai, Wei-Yue Liu, Bo Li, Hui Dai, Ming Li, Yong-Mei Huang, Lei Deng, Li Li, Qiang Zhang, Nai-Le Liu, Yu-Ao Chen, Chao-Yang Lu, Rong Shu, Cheng-Zhi Peng, Jian-Yu Wang, Jian-Wei Pan
We report on entanglement-based quantum key distribution between a low-Earth-orbit satellite equipped with a space borne entangled-photon source and a ground observatory. One of the entangled photons is measured locally at the satellite, and the other one is sent via a down link to the receiver in the Delingha ground station. The link attenuation is measured to vary from 29 dB at 530 km to 36 dB at 1000 km. We observe that the two-photon entanglement survives after being distributed between the satellite and the ground, with a measured state fidelity of ≥0...
November 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29219211/homoepitaxial-growth-of-large-scale-highly-organized-transition-metal-dichalcogenide-patterns
#14
Jianyi Chen, Xiaoxu Zhao, Gustavo Grinblat, Zhongxin Chen, Sherman J R Tan, Wei Fu, Zijing Ding, Ibrahim Abdelwahab, Yi Li, Dechao Geng, Yanpeng Liu, Kai Leng, Bo Liu, Wei Liu, Wei Tang, Stefan A Maier, Stephen John Pennycook, Kian Ping Loh
Controllable growth of highly crystalline transition metal dichalcogenide (TMD) patterns with regular morphology and unique edge structure is highly desired and important for fundamental research and potential applications. Here, single-crystalline MoS2 flakes are reported with regular trigonal symmetric patterns that can be homoepitaxially grown on MoS2 monolayer via chemical vapor deposition. The highly organized MoS2 patterns are rhombohedral (3R)-stacked with the underlying MoS2 monolayer, and their boundaries are predominantly terminated by zigzag Mo edge structure...
December 8, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29218103/microrna-429-sensitizes-pancreatic-cancer-cells-to-gemcitabine-through-regulation-of-pdcd4
#15
Gang Yu, Benli Jia, Yunsheng Cheng, Lianbang Zhou, Bo Qian, Zhining Liu, Yong Wang
One of the features for pancreatic cancer is that it is often resistant to chemotherapy treatment, which is one of the major hindrances in the treatment of this malignancy. Previous studies indicated that the microRNAs (miRNAs) could mediate resistance of tumor cells to chemotherapy drug in the cancer progression. In the present study, we are aimed to examine whether microRNA-429 was involved in mediating the chemo-resistance of pancreatic cancer cells to gemcitabine. Firstly, a gemcitabine-resistant pancreatic cancer cell line (SW1990/GZ) derived from cell line (SW1990) was constructed and found to possess a decreased expression of miR-429 when it is compared to the original cell line...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29218081/tetramethylpyrazine-phosphate-and-borneol-combination-therapy-synergistically-attenuated-ischemia-reperfusion-injury-of-the-hypothalamus-and-striatum-via-regulation-of-apoptosis-and-autophagy-in-a-rat-model
#16
Bin Yu, Ming Ruan, Tao Liang, Shi-Wen Huang, Sheng-Jin Liu, Hai-Bo Cheng, Xiang-Chun Shen
The combination of tetramethylpyrazine (TMP) and borneol (BO) has shown promise for treatment of cerebral ischemia in clinical and experimental studies. However, the mechanism for the synergistic effect of these compounds is unclear. In this study, global cerebral ischemia-reperfusion (GCIR) was induced in rats that were subsequently treated with tetramethylpyrazine phosphate (TMPP) (13.3 mg/kg), BO (0.16 g/kg), or the combination TMPP + BO. Neuronal ultrastructure and intracellular calcium [Ca2+]i levels were evaluated in hypothalamus and striatum...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29217484/the-impact-of-protein-interaction-networks-characteristics-on-computational-complex-detection-methods
#17
Xiaoxia Liu, Zhihao Yang, Ziwei Zhou, Yuanyuan Sun, Hongfei Lin, Jian Wang, Bo Xu
Protein complexes of physically interacting proteins play an important role in organizing various biological processes in the cell. Therefore, correctly identifying complexes is useful for deciphering the cellular mechanisms underlying many biological processes. Since the existing high-throughput techniques have produced a large amount of protein interactions, computational methods are useful complements to the experimental methods for detecting protein complexes. In this paper, we analyze six protein interaction networks widely used for protein complex detection, and compare the performance of six classic computational methods on them in order to find the impacts of network characteristics on the performances of these complex detection methods...
December 4, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29216960/estimation-study-of-new-cancer-cases-and-deaths-in-wuwei-hexi-corridor-region-china-2018
#18
Bo Yu Cao, Cheng Yun Li, Feng Lan Xu, Xiao Qin Liu, Yan Xu Yang, Jing Li, Cai Yun Gao, You Ming Rong, Rong Cheng Li, Ya Li Li, Shan Zheng, Ya Na Bai, Yan Cheng Ye
Population-based cancer registration data were collected to estimate the cancer incidence and mortality in Wuwei, Hexi Corridor Region, China in 2018. We used the 2011-2013 data to predict the number of new cases and deaths in 2018 and the 2003-2013 data to analyze trends in cancer incidence and mortality. The goal is to enable cancer prevention and control directions. Our results indicated that stomach cancer is the most common cancer. For all cancers combined, the incidence and mortality rates showed significantly increasing trends (+2...
November 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29216628/mir-212-5p-suppresses-the-epithelial-mesenchymal-transition-in-triple-negative-breast-cancer-by-targeting-prrx2
#19
Zhi-Dong Lv, Dong-Xia Yang, Xiang-Ping Liu, Li-Ying Jin, Xin-Gang Wang, Zhao-Chuan Yang, Dong Liu, Jiao-Jiao Zhao, Bin Kong, Fu-Nian Li, Hai-Bo Wang
BACKGROUND/AIMS: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Our study investigated the functional role of miR-212-5p in TNBC. METHODS: Realtime PCR was used to quantify miR-212-5p expression levels in 30 paired TNBC samples and adjacent normal tissues. Wound healing and Transwell assays were used to evaluate the effects of miR-212-5p expression on the invasiveness of TNBC cells. Luciferase reporter and Western blot assays were used to verify whether the mRNA encoding Prrx2 is a major target of miR-212-5p...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29215863/near-infrared-laser-excited-nanoparticles-to-eradicate-multidrug-resistant-bacteria-and-promote-wound-healing
#20
Yue Qiao, Fei Ma, Chao Liu, Bo Zhou, Qiaolin Wei, Wanlin Li, Danni Zhong, Yangyang Li, Min Zhou
With the ever-growing threat of bacterial infections, especially for multidrug-resistant microbial infections, the development of highly effective treatment modalities to inhibit the infections is challenging. Although silver nanoparticles have been intensively applied as an antimicrobial agent for decades, the therapeutic efficacy towards multidrug-resistant bacteria is still unsatisfactory. Here, we show that near-infrared (NIR) laser-excited silver triangular nanoparticles (Tri-Ag) can efficiently kill Gram-negative Escherichia coli (E...
December 7, 2017: ACS Applied Materials & Interfaces
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