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https://www.readbyqxmd.com/read/28239915/rapid-analysis-of-corni-fructus-using-paper-spray-mass-spectrometry
#1
Yuan Guo, Zhixin Gu, Xuemei Liu, Jingjing Liu, Ming Ma, Bo Chen, Liping Wang
INTRODUCTION: Paper spray-mass spectrometry (PS-MS) is a kind of ambient MS technique for the rapid analysis of samples. Corni fructus has been widely used in traditional Chinese compound preparations and healthy food. However, a number of counterfeits of Corni fructus, such as Crataegi fructus, Lycii fructus, and grape skin are illegally sold in crude herb markets. Therefore, the development of a rapid and high-throughput quality evaluation method is important for ensuring the effectiveness and safety of the crude materials of Corni fructus...
February 26, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28239413/improving-acetyl-coa-biosynthesis-in-saccharomyces-cerevisiae-via-the-overexpression-of-pantothenate-kinase-and-pdh-bypass
#2
Wenshan Liu, Bo Zhang, Rongrong Jiang
BACKGROUND: Acetyl-CoA is an important precursor in Saccharomyces cerevisiae. Various approaches have been adopted to improve its cytosolic level previously with the emphasis on engineering the "acetyl-" part of acetyl-CoA. To the best of our knowledge, there have been no reports on engineering the "-CoA" part so far. RESULTS: In this study, we had tried to engineer S. cerevisiae from both the "-CoA" part via pantothenate kinase overexpression (PanK from S. cerevisiae, the rate-limiting enzyme for CoA synthesis) and the "acetyl-"part through PDH bypass introduction (ALD6 from S...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28239382/mouse-testicular-cell-type-specific-antiviral-response-against-mumps-virus-replication
#3
Han Wu, Xiang Zhao, Fei Wang, Qian Jiang, Lili Shi, Maolei Gong, Weihua Liu, Bo Gao, Chengyi Song, Qihan Li, Yongmei Chen, Daishu Han
Mumps virus (MuV) infection has high tropism to the testis and usually leads to orchitis, an etiological factor in male infertility. However, MuV replication in testicular cells and the cellular antiviral responses against MuV are not fully understood. The present study showed that MuV infected the majority of testicular cells, including Leydig cells (LC), testicular macrophages, Sertoli cells (SC), and male germ cells (GC). MuV was replicated at relatively high efficiencies in SC compared with LC and testicular macrophages...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28239160/insights-into-the-molecular-mechanisms-of-polygonum-multiflorum-thunb-induced-liver-injury-a-computational-systems-toxicology-approach
#4
Yin-Yin Wang, Jie Li, Zeng-Rui Wu, Bo Zhang, Hong-Bin Yang, Qin Wang, Ying-Chun Cai, Gui-Xia Liu, Wei-Hua Li, Yun Tang
An increasing number of cases of herb-induced liver injury (HILI) have been reported, presenting new clinical challenges. In this study, taking Polygonum multiflorum Thunb (PmT) as an example, we proposed a computational systems toxicology approach to explore the molecular mechanisms of HILI. First, the chemical components of PmT were extracted from 3 main TCM databases as well as the literature related to natural products. Then, the known targets were collected through data integration, and the potential compound-target interactions (CTIs) were predicted using our substructure-drug-target network-based inference (SDTNBI) method...
February 27, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28238784/deacetylation-of-ku70-by-sirt6-attenuates-bax-mediated-apoptosis-in-hepatocellular-carcinoma
#5
Na-Na Tao, Ji-Hua Ren, Hua Tang, Long-Kuan Ran, Hong-Zhong Zhou, Bo Liu, Ai-Long Huang, Juan Chen
SIRT6 is a class III histone deacetylase that has been implicated in HCC development. We previously reported that SIRT6 potentiated apoptosis evasion in hepatocellular carcinoma by inhibiting both Bax expression and mitochondrial translocalization. However, the mechanism underlying SIRT6-mediated inhibition of Bax mitochondrial localization remains elusive. In this study, we found that although SIRT6 had no effect on the expression level of Ku70, SIRT6 could interact with Ku70 and deacetylate it. The increased acetylation of Ku70 in SIRT6-depleted cells disrupt its interaction with Bax, which finally resulted in Bax mitochondrial translocalization...
February 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28238544/the-mechanisms-of-heavy-metal-immobilization-by-cementitious-material-treatments-and-thermal-treatments-a-review
#6
REVIEW
Bin Guo, Bo Liu, Jian Yang, Shengen Zhang
Safe disposal of solid wastes containing heavy metals is a significant task for environment protection. Immobilization treatment is an effective technology to achieve this task. Cementitious material treatments and thermal treatments are two types of attractive immobilization treatments due to that the heavy metals could be encapsulated in their dense and durable wasteforms. This paper discusses the heavy metal immobilization mechanisms of these methods in detail. Physical encapsulation and chemical stabilization are two fundamental mechanisms that occur simultaneously during the immobilization processes...
February 23, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28238215/pretreatment-platelet-to-lymphocyte-ratio-is-associated-with-the-response-to-first-line-chemotherapy-and-survival-in-patients-with-metastatic-gastric-cancer
#7
Jin Wang, Jinglei Qu, Zhi Li, Xiaofang Che, Jing Liu, Yuee Teng, Bo Jin, Mingfang Zhao, Yunpeng Liu, Xiujuan Qu
BACKGROUND: Several studies have shown that platelet-to-lymphocyte ratio (PLR) is a prognostic factor for various cancers. However, there is no study about the role of PLR in predicting response to first-line chemotherapy of metastatic gastric cancer. Therefore, this study aimed to establish whether PLR is associated with the response to first-line chemotherapy and survival in patients with metastatic gastric cancer. METHODS: We enrolled 273 patients diagnosed with metastatic gastric cancer...
February 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28237626/effects-of-cryopreservation-at-various-temperatures-on-the-survival-of-kelp-grouper-epinephelus-moara-embryos-from-fertilization-with-cryopreserved-sperm
#8
Yongsheng Tian, Zhangfan Chen, Jiang Tang, Huimin Duan, Jieming Zhai, Bo Li, Wenhui Ma, Jiangchun Liu, Yunxia Hou, Zhengxiang Sun
Fish embryo cryopreservation is highly important for the long-term preservation of genomic and genetic information; however, few successful cases of fish embryo cryopreservation have been reported over the past 60 years. This is the first study to use Epinephelus moara embryos from fertilization with cryopreserved sperm as experimental material. Embryos that developed to the 16-22 somite stage and tail-bud stage were treated with the vitrification solution PMG3T according to a five-step equilibration method and cryopreserved at various temperatures and storage duration...
February 22, 2017: Cryobiology
https://www.readbyqxmd.com/read/28237479/sevoflurane-pretreatment-inhibits-the-myocardial-apoptosis-caused-by-hypoxia-reoxygenation-through-ampk-pathway-an-experimental-study
#9
Zhao-Ying Liu, Shun-Peng Hu, Qing-Rong Ji, Hai-Bo Yang, Dong-Hao Zhou, Fang-Fang Wu
OBJECTIVE: To study whether sevoflurane pretreatment inhibits the myocardial apoptosis caused by hypoxia reoxygenation through AMPK pathway. METHODS: H9c2 myocardial cell lines were cultured and divided into control group (C group), hypoxia reoxygenation group (H/R group), sevoflurane pretreatment + hypoxia reoxygenation group (SP group) and sevoflurane combined with Compound C pretreatment + hypoxia reoxygenation group (ComC group), and the cell proliferation activity and apoptosis rate, myocardial enzyme levels in culture medium as well as the expression of apoptosis genes and p-AMPK in cells were determined...
February 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28237302/yiqifumai-powder-injection-attenuates-coronary-artery-ligation-induced-myocardial-remodeling-and-heart-failure-through-modulating-mapks-signaling-pathway
#10
Li-Zhi Pang, Ai-Chun Ju, Xian-Jie Zheng, Fang Li, Yun-Fei Song, Yan Zhao, Yuan-Feng Gu, Fei-Leng Chen, Chun-Hua Liu, Jin Qi, Zhen Gao, Jun-Ping Kou, Bo-Yang Yu
ETHNOPHARMACOLOGICAL RELEVANCE: YiQiFuMai Powder Injection (YQFM), a traditional Chinese medicine prescription re-developed based on Sheng-Mai-San, is a classical and traditional therapeutic for clinical heart failure (HF) and angina. However, its potential mechanism against HF remains unclear. AIM OF THE STUDY: The present study observes the therapeutic role of YQFM and mechanisms underlying its effects on coronary artery ligation (CAL)-induced myocardial remodeling (MR) and HF...
February 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28237028/association-between-slc11a1-nramp1-polymorphisms-and-susceptibility-to-tuberculosis-in-chinese-holstein-cattle
#11
Kaihua Liu, Bin Zhang, Zhaochun Teng, Youtao Wang, Guodong Dong, Cong Xu, Bo Qin, Chunlian Song, Jun Chai, Yang Li, Xianwei Shi, Xianghua Shu, Yifang Zhang
We investigated the associations between SLC11A1 polymorphisms and susceptibility to tuberculosis (TB) in Chinese Holstein cattle, using a case-control study of 136 animals that had positive reactions to TB tests and showed symptoms and 96 animals that had negative reactions to tests and showed no symptoms. Polymerase chain reaction (PCR) sequencing and the restriction fragment length polymorphism (RFLP) technique were used to detect and determine SLC11A1 polymorphisms. Association analysis identified significant correlations between SLC11A1 polymorphisms and susceptibility/resistance to TB, and two genetic markers for SLC11A1 were established using PCR-RFLP...
March 2017: Tuberculosis
https://www.readbyqxmd.com/read/28236410/screening-and-evaluation-of-commonly-used-anti-influenza-chinese-herbal-medicines-based-on-anti-neuraminidase-activity
#12
Xue Han, Ding-Kun Zhang, Yu-Ming Guo, Wu-Wen Feng, Qin Dong, Cong-En Zhang, Yong-Feng Zhou, Yan Liu, Jia-Bo Wang, Yan-Ling Zhao, Xiao-He Xiao, Ming Yang
Anti-influenza Chinese herbal medicines (anti-flu CHMs) have advantages in preventing and treating influenza virus infection. Despite various data on antiviral activities of some anti-flu CHMs have been reported, most of them could not be compared using the standard evaluation methods for antiviral activity. This situation poses an obstacle to a wide application of anti-flu CHMs. Thus, it was necessary to develop an evaluation method to estimate antiviral activities of anti-flu CHMs. In the present study, we searched for anti-flu CHMs, based on clinic usage, to select study objects from commonly-used patented anti-flu Chinese medicines...
October 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28236202/oxygen-microprofiles-within-the-sediment-water-interface-studied-by-optode-and-its-implication-for-aeration-of-polluted-urban-rivers
#13
Bo Liu, Rui-Ming Han, Wen-Lin Wang, Hong Yao, Feng Zhou
To reveal the detailed vertical oxygen distribution at the sediment-water interface (SWI) and its relation with the oxygen consumption processes during and after aeration of polluted urban rivers, experimental systems constructed with collected sediment and in situ overlying water from a polluted urban river were aerated above or beneath the sediment-water interface 12 h a day for 15 days and left nonaerated for the following 10 days. The results showed that aeration of water or sediment both increased dissolved oxygen (DO) concentrations in the SWI, characterized by shifts in a "decrease-increase-decrease" manner during around 3 h for the aeration of water treatment (AW) and 6 h for the aeration of sediment treatment (AS)...
February 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28235726/adjuvant-chemotherapy-in-patients-with-locoregionally-advanced-nasopharyngeal-carcinoma-long-term-results-of-a-phase-3-multicentre-randomised-controlled-trial
#14
Lei Chen, Chao-Su Hu, Xiao-Zhong Chen, Guo-Qing Hu, Zhi-Bin Cheng, Yan Sun, Wei-Xiong Li, Yuan-Yuan Chen, Fang-Yun Xie, Shao-Bo Liang, Yong Chen, Ting-Ting Xu, Bin Li, Guo-Xian Long, Si-Yang Wang, Bao-Min Zheng, Ying Guo, Ying Sun, Yan-Ping Mao, Ling-Long Tang, Yu-Ming Chen, Meng-Zhong Liu, Jun Ma
AIM OF THE STUDY: Previous results from our trial showed that adjuvant cisplatin and fluorouracil chemotherapy did not significantly improve survival after concurrent chemoradiotherapy (CCRT) in locoregionally advanced nasopharyngeal carcinoma (NPC) at 2 years. Here, we present the data of long-term survival and late toxicities to further assess the ultimate therapeutic index of adjuvant chemotherapy (AC). METHODS: Patients with stage III-IVB (except T3-4N0) NPC were randomly assigned to receive CCRT plus AC or CCRT only at seven institutions in China...
February 21, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28235668/analysis-of-delayed-discharge-after-day-surgery-laparoscopic-cholecystectomy
#15
Junning Cao, Bo Liu, Xiangjun Li, Jianjun Leng, Xiangfei Meng, Yingwei Pan, Songmeng Dou, Shichun Lu
BACKGROUND: (A sentence here has been trimmed.) Delayed discharge is the existing obstacle to further enhancing quality of recovery after Day-surgery laparoscopic cholecystectomy (LC/DS). This study aims to analyze the reasons for delayed discharge after LC/DS. METHODS: The 745 patients with delayed discharge after LC/DS were retrospectively studied. The reasons for delayed discharge and data related to patients were collected and analyzed. Psychosocial reasons were defined by meeting discharge criteria but refusing to discharge, and complications were defined and graded using the "Clavien-Dindo" classification system...
February 21, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28231288/characterization-and-expression-analysis-of-genes-encoding-ubiquitin-conjugating-domain-containing-enzymes-in-carica-papaya
#16
Dengwei Jue, Xuelian Sang, Bo Shu, Liqin Liu, Yicheng Wang, Zhiwei Jia, Yu Zou, Shengyou Shi
BACKGROUND: Ripening affects the quality and nutritional contents of fleshy fruits and is a crucial process of fruit development. Although several studies have suggested that ubiquitin-conjugating enzyme (E2s or UBC enzymes) are involved in the regulation of fruit ripening, little is known about the function of E2s in papaya (Carica papaya). METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we searched the papaya genome and identified 34 putative UBC genes, which were clustered into 17 phylogenetic subgroups...
2017: PloS One
https://www.readbyqxmd.com/read/28228606/genetic-polymorphisms-rs10636-and-rs28366003-in-metallothionein-2a-increase-breast-cancer-risk-in-chinese-han-population
#17
Di Liu, Meng Wang, Tian Tian, Xi-Jing Wang, Hua-Feng Kang, Tian-Bo Jin, Shu-Qun Zhang, Hai-Tao Guan, Peng-Tao Yang, Kang Liu, Xing-Han Liu, Peng Xu, Yi Zheng, Zhi-Jun Dai
Genetic polymorphisms of MT2A are frequently observed in many different cancers. We performed this case-control study, including 459 breast cancer (BC) patients and 549 healthy controls from Northwest China, to evaluate the associations between two common MT2A polymorphisms (rs10636 and rs28366003) and BC risk. The MT2A polymorphisms were genotyped via Sequenom MassARRAY. The individuals with the rs28366003 A/G, A/G-G/G genotypes underwent a higher risk of BC (P<0.0001). And, the minor allele G of rs28366003 was related to an increased BC risk (P<0...
February 22, 2017: Aging
https://www.readbyqxmd.com/read/28228589/capsid-phosphorylation-state-and-hepadnavirus-virion-secretion
#18
Xiaojun Ning, Suresh H Basagoudanavar, Kuancheng Liu, Laurie Luckenbaugh, Duoqian Wei, Chunyan Wang, Bo Wei, Yingren Zhao, Taotao Yan, William Delaney, Jianming Hu
The C-terminal domain (CTD) of hepadnavirus core protein is involved in multiple steps of viral replication. In particular, CTD is initially phosphorylated at multiple sites to facilitate viral RNA packaging into immature nucleocapsids (NCs) and the early stage of viral DNA synthesis. For the avian hepadnavirus, the duck hepatitis B virus (DHBV), CTD is dephosphorylated subsequently to facilitate the late stage of viral DNA synthesis and to stabilize NCs containing mature viral DNA. The role of CTD phosphorylation in virion secretion, if any, has remained unclear...
February 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28228481/a-helical-bundle-in-the-n-terminal-domain-of-the-blm-helicase-mediates-dimer-and-potentially-hexamer-formation
#19
Jing Shi, Wei-Fei Chen, Bo Zhang, San-Hong Fan, Xia Ai, Na-Nv Liu, Stephane Rety, Xu-Guang Xi
Helicases play a critical role in processes such as replication or recombination by unwinding double-stranded DNA; mutations of these genes can therefore have devastating biological consequences. In human, mutations in genes of three members of the RecQ family helicases (blm, wrn and recq4) give rise to three strikingly distinctive clinical phenotypes: Bloom syndrome, Werner syndrome and Rothmund-Thomson syndrome, respectively. However, the molecular basis for these varying phenotypic outcomes is unclear, in part because a full mechanistic description of helicase activity is lacking...
February 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28225257/exploiting-noncovalently-conformational-locking-as-a-design-strategy-for-high-performance-fused-ring-electron-acceptor-used-in-polymer-solar-cells
#20
Yahui Liu, Zhe Zhang, Shiyu Feng, Miao Li, Liangliang Wu, Ran Hou, Xinjun Xu, Xuebo Chen, Zhishan Bo
We have developed a kind of novel fused-ring small molecular acceptor, whose planar conformation can be locked by intramolecular noncovalent interaction. The formation of planar supramolecular fused-ring structure by conformation locking can effectively broaden its absorption spectrum, enhance the electron mobility, and reduce the nonradiative energy loss. Polymer solar cells (PSCs) based on this acceptor afforded a power conversion efficiency (PCE) of 9.6%. In contrast, PSCs based on similar acceptor, which cannot form a flat conformation, only gave a PCE of 2...
February 24, 2017: Journal of the American Chemical Society
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