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https://www.readbyqxmd.com/read/27904268/clinicopathological-features-and-immunohistochemical-alterations-of-keratinocyte-proliferation-melanocyte-density-smooth-muscle-hyperplasia-and-nerve-fiber-distribution-in-becker-s-nevus
#1
Ping Sheng, Yun-Long Cheng, Chuan-Chuan Cai, Wei-Jin Guo, Ying Zhou, Ge Shi, Yi-Ming Fan
BACKGROUND: Although Becker's nevus (BN) is a relatively common disease, the systematic studies of clinicopathological and immunohistochemical results are poorly reported. OBJECTIVE: To investigate the clinicopathological features and immunohistochemical alterations of keratinocyte proliferation, melanocyte density, smooth muscle hyperplasia and nerve fiber distribution in BN. METHODS: Clinical and pathological data were collected in 60 newly-diagnosed BN cases...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27893419/silver-nanoparticles-enhance-the-sensitivity-of-temozolomide-on-human-glioma-cells
#2
Ping Liang, Hongming Shi, Weiguo Zhu, Qunfeng Gui, Ya Xu, Jianfeng Meng, Xiaoyuan Guo, Zhuang Gong, Huaqun Chen
Glioblastoma multiforme (GBM) continues to be associated with a dismal prognosis despite aggressive treatment. Significant efforts are being made to develop new nanotechnology-based therapeutic and diagnostic agents. Nanoparticles can act directly on cancer cells or as drug carriers to enhance the cancer therapeutic effect. In this study, we investigated the effect of silver nanoparticles (AgNPs) on human glioma U251 cells and its role in the combinational use with Temozolomide (TMZ), an imidazotetrazine derivative of the alkylating agent dacarbazine, against glioma cells...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27881336/-outcome-analysis-of-monozygotic-twin-pregnancy-conceived-by-assisted-reproductive-techniques
#3
Shu-Xian Feng, Xue-Lan Li, Xing-Yu Zhou, Yu-Dong Liu, Ping-Ping Guo, De-Sheng Ye, Xin Chen, Shi-Ling Chen
OBJECTIVE: To analyze the incidence, management, and outcomes of monozygotic twin (MZT) pregnancy conceived by assisted reproductive techniques (ART). METHODS: A retrospective analysis was performed of clinical pregnancies after in vitro fertilization and embryo transfer (IVF-ET) and introcytoplasmic sperm injection and embryo transfer (ICSI-ET) from January, 2010 to June 2015 at our center. We investigated the incidence, managements and outcomes of 94 MZT pregnancies...
November 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27866995/an-integrated-decision-making-approach-for-assessing-healthcare-waste-treatment-technologies-from-a-multiple-stakeholder
#4
Hua Shi, Hu-Chen Liu, Ping Li, Xue-Guo Xu
With increased worldwide awareness of environmental issues, healthcare waste (HCW) management has received much attention from both researchers and practitioners over the past decade. The task of selecting the optimum treatment technology for HCWs is a challenging decision making problem involving conflicting evaluation criteria and multiple stakeholders. In this paper, we develop an integrated decision making framework based on cloud model and MABAC method for evaluating and selecting the best HCW treatment technology from a multiple stakeholder perspective...
November 17, 2016: Waste Management
https://www.readbyqxmd.com/read/27866106/denitrification-in-an-integrated-bioelectro-photocatalytic-system
#5
Zhi-Qi Lin, Shi-Jie Yuan, Wen-Wei Li, Jie-Jie Chen, Guo-Ping Sheng, Han-Qing Yu
Since nitrate causes severe ecological and health risks, nitrate contamination of drinking water sources has become one of the most important water quality concerns all over the world. Photocatalytic reduction of nitrate to molecular nitrogen presents a promising approach to remove nitrate from drinking water sources. However, harmful intermediates like NO2(-), NO, NO2 and N2O are usually formed, and metal loading or hole scavengers are generally needed to reduce the recombination of photo-generated electrons and holes, which will cause secondary pollution to drinking water...
November 14, 2016: Water Research
https://www.readbyqxmd.com/read/27861374/a-nomogram-for-predicting-the-likelihood-of-lymph-node-metastasis-in-early-gastric-signet-ring-cell-carcinoma-a-single-center-retrospective-analysis-with-external-validation
#6
Chun Guang Guo, Yan Jia Chen, Hu Ren, Hong Zhou, Ju Fang Shi, Xing Hua Yuan, Ping Zhao, Dong Bing Zhao, Gui Qi Wang
Treatment algorithm has not been established for early gastric cancer with signet ring cell carcinoma (SRC), which has a reported low rate of lymph node metastasis (LNM) similar to differentiated cancer. A cohort of 256 patients with early gastric SRC at our center between January 2002 and December 2015 were retrospectively reviewed. Multivariate logistic regression analysis was used to determine the independent factors of LNM. A nomogram for predicting LNM was constructed and internally validated. Additional external validation was performed using the database from Cancer Institute Ariake Hospital in Tokyo (n = 1273)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27860300/expert-consensus-on-perioperative-use-of-medications-during-endoscopic-submucosal-dissection-esd-for-gastric-lesions-2015-suzhou-china
#7
Yu Bai, Jian-Ting Cai, You Xiang Chen, Fei Gao, Xiao Zhong Guo, Xue Gang Guo, Ying Han, Jian Yu Hao, Shui Xiang He, Ming Ji, Bo Jiang, Hui Qing Jiang, Zhen Dong Jin, Yan Qing Li, Zhao Shen Li, Zhuan Liao, Feng Liu, Zhi Guo Liu, He Sheng Luo, Bin Lv, Nong Hua Lv, Xu Ren, Jian Qiu Sheng, Rui Hua Shi, De An Tian, Fang Yu Wang, Gui Qi Wang, Ai Ming Yang, Guo Xin Zhang, Zhen Yu Zhang, Fa Chao Zhi, Duo Wu Zou, Xiao Ping Zou
No abstract text is available yet for this article.
November 11, 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27848249/cystathionine-%C3%AE-lyase-deficiency-exacerbates-ccl4-induced-acute-hepatitis-and-fibrosis-in-the-mouse-liver
#8
Lei Ci, Xing Yu Yang, Xiao Wen Gu, Qing Li, Yang Guo, Zi Ping Zhou, Meng Jie Zhang, Jia Hao Shi, Hua Yang, Zhu Gang Wang, Jian Fei
AIMS: The present study examined the role of cystathionine γ-lyase (CSE) in CCl4- induced liver damage. RESULTS: A CSE gene knock-out and luciferase gene knock-in mouse model was constructed to study the function of CSE and trace its expression in living status. CCl4 or LPS markedly downregulated CSE expression in the liver of mice. CSE-deficient mice showed increased serum alanine aminotransferase and aspartate aminotransferase levels, and liver damage after CCl4 challenge, whereas albumin and endogenous H2S levels decreased significantly...
November 16, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27829229/knockdown-of-trim65-inhibits-lung-cancer-cell-proliferation-migration-and-invasion-a-therapeutic-target-in-human-lung-cancer
#9
Xiao-Lin Wang, Wei-Ping Shi, Hong-Can Shi, Shi-Chun Lu, Kang Wang, Chao Sun, Jian-Sheng He, Wei-Guo Jin, Xiao-Xia Lv, Hui Zou, Yu-Sheng Shu
Lung cancer is the most commonly diagnosed type of cancer worldwide. Although TRIM65 is an important protein involved in white matter lesion, the role of TRIM65 in human cancer remains less understood. Here, we reported that TRIM65 was significantly overexpressed in lung cancer tissues compared with adjacent normal lung tissues. Furthermore, TRIM65 expression was closely related to overall survival of patients with lung cancer. Knock down of TRIM65 in two lung cancer cell lines, SPC-A-1 and NCI-H358, resulted in a significant reduction in cell proliferation, migration, invasion and adhesion and a dramatic increase in G0-G1 phase arrest and apoptosis...
November 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/27827400/arbuscular-mycorrhizal-fungal-community-composition-affected-by-original-elevation-rather-than-translocation-along-an-altitudinal-gradient-on-the-qinghai-tibet-plateau
#10
Wei Yang, Yong Zheng, Cheng Gao, Ji-Chuang Duan, Shi-Ping Wang, Liang-Dong Guo
Elucidating arbuscular mycorrhizal (AM) fungal responses to elevation changes is critical to improve understanding of microbial function in ecosystems under global asymmetrical climate change scenarios. Here we examined AM fungal community in a two-year reciprocal translocation of vegetation-intact soil blocks along an altitudinal gradient (3,200 m to 3,800 m) in an alpine meadow on the Qinghai-Tibet Plateau. AM fungal spore density was significantly higher at lower elevation than at higher elevation regardless of translocation, except that this parameter was significantly increased by upward translocation from original 3,200 m to 3,400 m and 3,600 m...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27824035/erratum-genomic-and-oncogenic-preference-of-hbv-integration-in-hepatocellular-carcinoma
#11
Ling-Hao Zhao, Xiao Liu, He-Xin Yan, Wei-Yang Li, Xi Zeng, Yuan Yang, Jie Zhao, Shi-Ping Liu, Xue-Han Zhuang, Chuan Lin, Chen-Jie Qin, Yi Zhao, Ze-Ya Pan, Gang Huang, Hui Liu, Jin Zhang, Ruo-Yu Wang, Yun Yang, Wen Wen, Gui-Shuai Lv, Hui-Lu Zhang, Han Wu, Shuai Huang, Ming-Da Wang, Liang Tang, Hong-Zhi Cao, Ling Wang, Tin-Lap Lee, Hui Jiang, Ye-Xiong Tan, Sheng-Xian Yuan, Guo-Jun Hou, Qi-Fei Tao, Qin-Guo Xu, Xiu-Qing Zhang, Meng-Chao Wu, Xun Xu, Jun Wang, Huan-Ming Yang, Wei-Ping Zhou, Hong-Yang Wang
No abstract text is available yet for this article.
November 8, 2016: Nature Communications
https://www.readbyqxmd.com/read/27823995/analysis-of-in-hospital-neonatal-death-in-the-tertiary-neonatal-intensive-care-unit-in-china-a-multicenter-retrospective-study
#12
Chen-Hong Wang, Li-Zhong Du, Xiao-Lu Ma, Li-Ping Shi, Xiao-Mei Tong, Hong Liu, Guo-Fang Ding, Bin Yi, Xin-Nian Pan, Dan-Ni Zhong, Ling Liu, Mei Li, Cui-Qing Liu, Shi-Wen Xia, Hong-Yun Wang, Ling He, Kun Liang, Xiao-Yu Zhou, Shu-Ping Han, Qin Lyu, Yin-Ping Qiu, Ruo-Bing Shan, De-Zhi Mu, Xiao-Hong Liu, Si-Qi Zhuang, Jing Guo, Li Liu, Jia-Jun Zhu, Hong Xiong
BACKGROUND: Globally, the proportion of child deaths that occur in the neonatal period remains a high level of 37-41%. Differences of cause in neonate death exist in different regions as well as in different economic development countries. The specific aim of this study was to investigate the causes, characteristics, and differences of death in neonates during hospitalization in the tertiary Neonatal Intensive Care Unit (NICU) of China. METHODS: All the dead neonates admitted to 26 NICUs were included between January l, 2011, and December 31, 2011...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27814269/preprocedural-high-sensitivity-c-reactive-protein-predicts-contrast-induced-nephropathy-and-long-term-outcome-after-coronary-angiography
#13
Xiao-Sheng Guo, Kai-Yang Lin, Hua-Long Li, Ji-Yan Chen, Ying-Ling Zhou, Yong Liu, Ning Tan, Emily R Atkins, Peng Ran, Jun-Qing Yang, Deng-Xuan Wu, Shi-Qun Chen, Chong-Yang Duan, Ping-Yan Chen
We investigated whether high-sensitivity C-reactive protein (hsCRP) levels were associated with contrast-induced nephropathy (CIN) and long-term mortality after coronary angiography (CAG). Patients (N = 2133) undergoing CAG with preprocedural hsCRP were consecutively enrolled. High-sensitivity C-reactive protein was measured before angiography. Median follow-up was 2.3 years. The overall incidence of CIN was 2.77% (59 of 2133). There was a positive trend of hsCRP quartiles (Q) with rates of CIN: 0.9% for Q1 (<1...
October 25, 2016: Angiology
https://www.readbyqxmd.com/read/27798375/chitosan-wound-dressings-incorporating-exosomes-derived-from-microrna-126-overexpressing-synovium-mesenchymal-stem-cells-provide-sustained-release-of-exosomes-and-heal-full-thickness-skin-defects-in-a-diabetic-rat-model
#14
Shi-Cong Tao, Shang-Chun Guo, Min Li, Qin-Fei Ke, Ya-Ping Guo, Chang-Qing Zhang
: : There is a need to find better strategies to promote wound healing, especially of chronic wounds, which remain a challenge. We found that synovium mesenchymal stem cells (SMSCs) have the ability to strongly promote cell proliferation of fibroblasts; however, they are ineffective at promoting angiogenesis. Using gene overexpression technology, we overexpressed microRNA-126-3p (miR-126-3p) and transferred the angiogenic ability of endothelial progenitor cells to SMSCs, promoting angiogenesis...
October 26, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27798013/safety-and-immunogenicity-of-a-new-13-valent-pneumococcal-conjugate-vaccine-versus-a-licensed-7-valent-pneumococcal-conjugate-vaccine-a-study-protocol-of-a-randomised-non-inferiority-trial-in-china
#15
Jing Jing Chen, Lin Yuan, Zhen Huang, Nian Min Shi, Yu Liang Zhao, Sheng Li Xia, Guo Hua Li, Rong Cheng Li, Yan Ping Li, Shu Yuan Yang, Jie Lai Xia
INTRODUCTION: The invasive pneumococcal diseases (IPDs) caused by Streptococcus pneumoniae pose an enormous threat to children under 5 years of age. However, routine use of pneumococcal conjugate vaccines could aid in reducing the incidence of IPDs. The purpose of this clinical trial is to assess the non-inferiority of the investigational 13-valent pneumococcal conjugate vaccine (PCV13) to the currently licensed 7-valent pneumococcal conjugate vaccine (PCV7). METHODS AND ANALYSIS: 1040 infants will receive a three-dose series of either PCV13 or PCV7 at ages 3, 4 and 5 months, respectively, and a booster dose at 12-15 months...
October 19, 2016: BMJ Open
https://www.readbyqxmd.com/read/27784377/-effect-of-cp-metronomic-chemotherapy-on-rpmi-8226-cell-proli-feration-and-notch1-nf-%C3%AE%C2%BAb-signaling-pathway-in-vitro
#16
Lie-Ping Guo, Fan Zhou, Hao-Tian Shi, Hai-Min Chen, Chen-Hui Lin, Xiao-Ling Chen, Jian Hou
OBJECTIVE: To investigate the effect of metronomic chemotherapy of low dose phosphoramide combined with prednisolone (CP metronomic chemotherapy) on proliferation and apoptosis of RPMI 8226 cells, and to explore its regulating effect on Notch1/NF-κB signaling pathways. METHODS: Experiment was divided into the DMSO control group, and the phosphoramide mustard (PM) group, the prednisolone group, the phosphoramide mustard plus prednisolone group (the CP group). RPMI 8226 cells were treated with different drugs, CCK-8 method was used to detect cell proliferation, flow cytometry was used to detect the cell cycle and apoptosis, reverse transcription PCR was used to detect Notch1 and NF-κB mRNA expression level...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27784171/physiopathological-factors-affecting-the-diagnostic-value-of-serum-he4-test-for-gynecologic-malignancies
#17
Wanglei Qu, Jinping Li, Ping Duan, Zuoqing Tang, Fengbiao Guo, Haibin Chen, Xueqiong Zhu, Shi-Wen Jiang
Serum epididymis protein 4 (HE4) represents a useful biomarker for the management of ovarian cancer and endometrial cancer patients. However, HE4 levels are affected by many physiopathological conditions or disorders that should be taken into consideration for an efficient application of this biomarker. Areas covered: The review provides an up-to-date reference on the multiple physiopathological factors that cause fluctuation of HE4 serum levels, and evaluates their impact on HE4-test in clinical settings. Potential mechanisms underlying the regulation of HE4 expression are also discussed...
November 17, 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27775603/zinc-finger-and-x-linked-factor-zfx-binds-to-human-set-transcript-2-promoter-and-transactivates-set-expression
#18
Siliang Xu, Ping Duan, Jinping Li, Tristan Senkowski, Fengbiao Guo, Haibin Chen, Alberto Romero, Yugui Cui, Jiayin Liu, Shi-Wen Jiang
SET (SE Translocation) protein carries out multiple functions including those for protein phosphatase 2A (PP2A) inhibition, histone modification, DNA repair, and gene regulation. SET overexpression has been detected in brain neurons of patients suffering Alzheimer's disease, follicle theca cells of Polycystic Ovary Syndrome (PCOS) patients, and ovarian cancer cells, indicating that SET may play a pathological role for these disorders. SET transcript 2, produced by a specific promoter, represents a major transcript variant in different cell types...
October 20, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27762212/seroprevalence-of-toxoplasma-gondii-in-goats-in-hunan-province-china
#19
Fen Li, Shi-Ping Wang, Chang-Jian Wang, Shi-Cheng He, Xiang Wu, Guo-Hua Liu
Toxoplasma gondii infections are prevalent in animals and humans worldwide. In the present investigation, the seroprevalence of T. gondii in goats was investigated in Hunan province, subtropical China between March 2014 and December 2015. A total of 1,028 serum samples collected from 14 administrative regions of Hunan province were evaluated by the indirect hemagglutination test (IHAT) for the detection of specific antibodies. Antibodies to T. gondii were detected in 124 serum samples (12%). The T. gondii seroprevalence ranged from 1...
2016: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/27753759/electroconvulsive-therapy-in-schizophrenia-in-china-a-national-survey
#20
Qian Li, Yun-Ai Su, Yu-Tao Xiang, Liang Shu, Xin Yu, Gabor S Ungvari, Stephen J Seiner, Helen F K Chiu, Yu-Ping Ning, Gao-Hua Wang, Ke-Rang Zhang, Tao Li, Li-Zhong Sun, Jian-Guo Shi, Xian-Sheng Chen, Qi-Yi Mei, Ke-Qing Li, Tian-Mei Si
OBJECTIVE: Little is known about electroconvulsive therapy (ECT) use in the treatment of schizophrenia in China. This study examined the frequency of ECT use, its trend between 2006 and 2012, and its independent demographic and clinical correlates in a nationwide survey in China. METHODS: A total of 5162 inpatients in 45 Chinese psychiatric hospitals/centers were interviewed (2696 in 2006 and 2466 in 2012). Patients' sociodemographic and clinical characteristics were recorded using a standardized protocol and data collection procedure...
October 7, 2016: Journal of ECT
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