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https://www.readbyqxmd.com/read/28933101/-discussion-on-relevant-theories-of-qi-blood-shen-and-formula-implication-of-guan-xin-jing-capsule
#1
Rui-Ping Li, Guo-Hua Yu, Jun-Fang Li, Shi-Huan Tang
In the field of traditional Chinese medicine(TCM),the definition of "Shen" contains a broad concept and a narrow concept. Broad "Shen" is the dominator and administrator of human vital movement,while narrow "Shen" means spirit, consciousness, thinking and emotions of human. "Shen" originates from innate essence of parents, and survives on acquired essence of water and food as well as the nutrition of its metaplastic Qi-Blood-Body fluid. Qi-Blood,the most precious asset of human body, is a quite important section of one person and the central material basis of "Shen-Zhi"...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28922026/characterization-of-quinolone-resistance-in-salmonella-enterica-from-farm-animals-in-china
#2
Ting-Ting Cao, Guo-Hui Deng, Liang-Xing Fang, Run-Shi Yang, Jian Sun, Ya-Hong Liu, Xiao-Ping Liao
This study was focused on the prevalence and antimicrobial susceptibilities of Salmonella directly isolated at animal clinics in Guangdong, People's Republic of China. The isolation rates from chickens, ducks, and pigs were 11.3% (11 of 97 samples), 15.4% (53 of 344 samples), and 3.0% (13 of 434 samples), respectively. Among the 77 Salmonella enterica isolates, the most predominant serovar was Typhimurium (81.8%, 63 isolates), followed by serovars Meleagridis (2.6%, 2 isolates) and Abaetetuba (1.3%, 1 isolate)...
September 18, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28919491/potential-involvement-of-fgf10-fgfr2-and-androgen-receptor-ar-in-renal-fibrosis-in-adult-male-rat-offspring-subjected-to-prenatal-exposure-to-di-n-butyl-phthalate-dbp
#3
Wen-Lan Sun, Yi-Ping Zhu, Xiu-Shi Ni, Da-Dao Jing, Yu-Ting Yao, Wei Ding, Zhi-Hong Liu, Guo-Xian Ding, Jun-Tao Jiang
BACKGROUND: We previously demonstrated that maternal exposure to di-n-butyl phthalate (DBP) induces dysplasia of the kidney in newborn male offspring and renal fibrosis in adults. But the underlying mechanisms remain elusive. Fgf10/Fgfr2 and androgen receptor (AR) are known to be important for renal development. We therefore investigated whether these genes are involved in DBP-induced renal fibrosis. MATERIALS AND METHODS: Using Sprague-Dawley rats and rat renal proximal tubular cells (NRK52E), we determined the potential involvement of Fgf10, Fgfr2 and AR in DBP-induced renal fibrosis...
September 14, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28915398/masculinization-and-reproductive-effects-in-western-mosquitofish-gambusia-affinis-after-long-term-exposure-to-androstenedione
#4
Li-Ping Hou, Yang Yang, Hu Shu, Guang-Guo Ying, Jian-Liang Zhao, Gui-Zhen Fang, Li Xin, Wen-Jun Shi, Li Yao, Xue-Mei Cheng
Androstenedione (AED) is a naturally occurring steroid hormone. It is metabolized to potent androgens, which may induce androgenic effects in fish. However, little is known whether and how the androgens interfere with the fish gonadal development and reproduction. This study aimed at demonstrating the effects of long-term AED exposure on reproduction and development in mosquitofish (Gambusia affinis). The growth, development and several morphological endpoints, including the segment number and length of anal fin, histological changes of gonads and liver, were evaluated in mosquitofish during development from fertilized embryo to adulthood (180 days) after exposure of AED at environmentally relevant concentrations...
September 12, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28886694/comparative-transcriptome-analysis-of-cotton-fiber-development-of-upland-cotton-gossypium-hirsutum-and-chromosome-segment-substitution-lines-from-g-hirsutum-%C3%A3-g-barbadense
#5
Peng-Tao Li, Mi Wang, Quan-Wei Lu, Qun Ge, Md Harun Or Rashid, Ai-Ying Liu, Ju-Wu Gong, Hai-Hong Shang, Wan-Kui Gong, Jun-Wen Li, Wei-Wu Song, Li-Xue Guo, Wei Su, Shao-Qi Li, Xiao-Ping Guo, Yu-Zhen Shi, You-Lu Yuan
BACKGROUND: How to develop new cotton varieties possessing high yield traits of Upland cotton and superior fiber quality traits of Sea Island cotton remains a key task for cotton breeders and researchers. While multiple attempts bring in little significant progresses, the development of Chromosome Segment Substitution Lines (CSSLs) from Gossypium barbadense in G. hirsutum background provided ideal materials for aforementioned breeding purposes in upland cotton improvement. Based on the excellent fiber performance and relatively clear chromosome substitution segments information identified by Simple Sequence Repeat (SSR) markers, two CSSLs, MBI9915 and MBI9749, together with the recurrent parent CCRI36 were chosen to conduct transcriptome sequencing during the development stages of fiber elongation and Secondary Cell Wall (SCW) synthesis (from 10DPA and 28DPA), aiming at revealing the mechanism of fiber development and the potential contribution of chromosome substitution segments from Sea Island cotton to fiber development of Upland cotton...
September 8, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28880268/cezanne-predicts-progression-and-adjuvant-tace-response-in-hepatocellular-carcinoma
#6
Jia-Hong Wang, Xiao-Ping Zhong, Yong-Fa Zhang, Xiao-Liang Wu, Shao-Hua Li, Pei-En Jian, Yi-Hong Ling, Ming Shi, Min-Shan Chen, Wei Wei, Rong-Ping Guo
We have previously reported that Cezanne could be a prognostic biomarker for survival in hepatocellular carcinoma (HCC) patients. However, the role of Cezanne genes in HCC cells and its response to postoperative adjuvant transcatheter arterial chemoembolization (TACE) in HCC patients remains unknown. In this study, Cezanne expression was detected in human HCC using real-time PCR, western blot and immunohistochemistry. The function of Cezanne in HCC cells was determined by Transwell invasion assays and nude mice metastasis assay...
September 7, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28870504/the-oxidized-phospholipid-povpc-impairs-endothelial-function-and-vasodilation-via-uncoupling-endothelial-nitric-oxide-synthase
#7
Feng-Xia Yan, Hua-Ming Li, Shang-Xuan Li, Shi-Hui He, Wei-Ping Dai, Yan Li, Tian-Tian Wang, Mao-Mao Shi, Hao-Xiang Yuan, Zhe Xu, Jia-Guo Zhou, Da-Sheng Ning, Zhi-Wei Mo, Zhi-Jun Ou, Jing-Song Ou
Endothelial dysfunction is an early stage of atherosclerosis. We recently have shown that 25-hydroxycholesterol found in atherosclerotic lesions could impair endothelial function and vasodilation by uncoupling and inhibiting endothelial nitric oxide synthase (eNOS). 1-Palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), the oxidation product of oxidized low-density lipoprotein, is another proinflammatory lipid and has also been found in atherosclerotic lesions. However, whether POVPC promotes atherosclerosis like 25-hydroxycholesterol remains unclear...
September 1, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28867647/inhibitory-effects-of-melatonin-on-titanium-particle-induced-inflammatory-bone-resorption-and-osteoclastogenesis-via-suppression-of-nf-%C3%AE%C2%BAb-signaling
#8
Zichuan Ping, Zhirong Wang, Jiawei Shi, Liangliang Wang, Xiaobin Guo, Wei Zhou, Xuanyang Hu, Xiexing Wu, Yu Liu, Wen Zhang, Huilin Yang, Yaozeng Xu, Ye Gu, Dechun Geng
Wear debris-induced peri-implant osteolysis challenges the longevity of implants. The host response to wear debris causes chronic inflammation, promotes bone resorption, and impairs bone formation. We previously demonstrated that melatonin enhances bone formation and attenuates wear debris-induced bone loss in vivo. However, whether melatonin inhibits chronic inflammation and bone resorption at sites of wear debris-induced osteolysis remains unclear. In this study, we examined the potential inhibitory effects of melatonin on titanium particle-induced inflammatory osteolysis in a murine calvarial model and on RANKL-induced osteoclastic formation in bone marrow-derived macrophages...
August 31, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28866117/association-of-post-procedural-early-within-24h-increases-in-serum-creatinine-with-all-cause-mortality-after-coronary-angiography
#9
Xiao-Sheng Guo, Shi-Qun Chen, Chong-Yang Duan, Hua-Long Li, Wei-Jie Bei, Yong Liu, Ning Tan, Ping-Yan Chen, Ji-Yan Chen
BACKGROUND: The majority of patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI) are discharged early, with only early (within 24h) serum creatinine (SCr) data available without evidence of clinical prognosis. We aimed to systemically evaluate the association between post-procedural early increase in SCr and all-cause mortality following CAG. METHODS: We performed a retrospective sub-study analysis within a prospective observational study including 3091 consecutive patients with baseline and post-procedural early (within 24h) SCr data...
September 1, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28861323/pou2f1-promotes-growth-and-metastasis-of-hepatocellular-carcinoma-through-the-fat1-signaling-pathway
#10
Hong Yan Zhu, Guan Yi Cao, Shi Ping Wang, Yu Chen, Guo Dong Liu, Yu Jie Gao, Jian Ping Hu
Increasing evidence suggests that POU domain class 2 transcription factor 1 (POU2F1) participates in carcinogenesis and cancer progression via promotion of cell proliferation and metastasis; however, the functional role of POU2F1 in hepatocellular carcinoma (HCC) is largely unknown. In this study, we determined that POU2F1 was significantly up-regulated in HCC tumor tissue and cell lines. We demonstrated that POU2F1 over-expression promoted HCC cell proliferation, colony formation, migration, and invasion, while silencing of POU2F1 inhibited these malignant phenotypes...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28859304/tilting-at-the-tilted-protease-balance-in-arterial-aneurysmal-disease
#11
Peter Libby, Galina K Sukhova, C Keith Ozaki, Guo-Ping Shi
No abstract text is available yet for this article.
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28856588/whole-blood-microrna-markers-are-associated-with-acute-respiratory-distress-syndrome
#12
Zhaozhong Zhu, Liming Liang, Ruyang Zhang, Yongyue Wei, Li Su, Paula Tejera, Yichen Guo, Zhaoxi Wang, Quan Lu, Andrea A Baccarelli, Xi Zhu, Ednan K Bajwa, B Taylor Thompson, Guo-Ping Shi, David C Christiani
BACKGROUND: MicroRNAs (miRNAs) can play important roles in inflammation and infection, which are common manifestations of acute respiratory distress syndrome (ARDS). We assessed if whole blood miRNAs were potential diagnostic biomarkers for human ARDS. METHODS: This nested case-control study (N = 530) examined a cohort of ARDS patients and critically ill at-risk controls. Whole blood miRNA profiles and logistic regression analyses identified miRNAs correlated with ARDS...
August 30, 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28856461/reducing-diacetyl-production-of-wine-by-overexpressing-bdh1-and-bdh2-in-saccharomyces-uvarum
#13
Ping Li, Xuewu Guo, Tingting Shi, Zhihui Hu, Yefu Chen, Liping Du, Dongguang Xiao
As a byproduct of yeast valine metabolism during fermentation, diacetyl can produce a buttery aroma in wine. However, high diacetyl concentrations generate an aromatic off-flavor and poor quality in wine. 2,3-Butanediol dehydrogenase encoded by BDH1 can catalyze the two reactions of acetoin from diacetyl and 2,3-butanediol from acetoin. BDH2 is a gene adjacent to BDH1, and these genes are regulated reciprocally. In this study, BDH1 and BDH2 were overexpressed in Saccharomyces uvarum to reduce the diacetyl production of wine either individually or in combination...
August 31, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28852054/tunable-odd-frequency-triplet-pairing-states-and-skyrmion-modes-in-chiral-p-wave-superconductor
#14
Yu-Feng Lou, Lin Wen, Guo-Qiao Zha, Shi-Ping Zhou
Bogliubov-de Gennes equations are solved self-consistently to investigate the properties of bound states in chiral p-wave superconductive disks. It shows that either an s-wave or the mixed d- and s-wave state with odd-frequency and spin-triplet symmetry is induced at the vortex core, depending both on the chirality of the pairing states and on the vortex topology. It is also found that the odd-frequency triplet even parity (OTE) bound state can be manipulated with a local non-magnetic potential. Interestingly, with an appropriate potential amplitude, the zero-energy OTE bound state can be stabilized at a distance from the vortex core and from the local potential...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28840443/preoperative-carbohydrate-antigen-19-9-its-neglected-role-in-alpha-fetoprotein-negative-hepatocellular-carcinoma-patients
#15
Liang-He Lu, Yong-Fa Zhang, Wei Wei, Ming Shi, Rong-Ping Guo
PURPOSE: The study aimed to investigate the prognostic role of the preoperative carbohydrate antigen 19-9 (CA19-9) level in alpha-fetoprotein (AFP)-negative (AFP < 25 ng/ml) hepatocellular carcinoma (HCC) patients. METHODS: From December 2004 to December 2013, 750 patients diagnosed with AFP-negative HCC following curative resection were enrolled. Both univariate and multivariate analyses were performed to clarify the prognostic factors for overall survival (OS) and disease-free survival (DFS)...
August 24, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28837146/adropin-deficiency-worsens-hfd-induced-metabolic-defects
#16
Shi Chen, Kai Zeng, Qi-Cai Liu, Zheng Guo, Sheng Zhang, Xiao-Rong Chen, Jian-Hua Lin, Jun-Ping Wen, Cheng-Fei Zhao, Xin-Hua Lin, Feng Gao
The limited efficacy of current treatment methods and increased type 2 diabetes mellitus (T2DM) incidence constitute an incentive for investigating how metabolic homeostasis is maintained, to improve treatment efficacy and identify novel treatment methods. We analyzed a three-generation family of Chinese origin with the common feature of T2DM attacks and fatty pancreas (FP), alongside 19 unrelated patients with FP and 58 cases with T2DM for genetic variations in Enho, serum adropin, and relative Treg amounts...
August 24, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28836571/pharmacological-inhibition-of-macrophage-toll-like-receptor-4-nuclear-factor-kappa-b-alleviates-rhabdomyolysis-induced-acute-kidney-injury
#17
Rong-Shuang Huang, Jiao-Jiao Zhou, Yu-Ying Feng, Min Shi, Fan Guo, Shen-Ju Gou, Stephen Salerno, Liang Ma, Ping Fu
BACKGROUND: Acute kidney injury (AKI) is the most common and life-threatening systemic complication of rhabdomyolysis. Inflammation plays an important role in the development of rhabdomyolysis-induced AKI. This study aimed to investigate the kidney model of AKI caused by rhabdomyolysis to verify the role of macrophage Toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) signaling pathway. METHODS: C57BL/6 mice were injected with a 50% glycerin solution at bilateral back limbs to induce rhabdomyolysis, and CLI-095 or pyrrolidine dithiocarbamate (PDTC) was intraperitoneally injected at 0...
August 21, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28831199/targeted-sequencing-and-functional-analysis-reveal-brain-size-related-genes-and-their-networks-in-autism-spectrum-disorders
#18
Jinchen Li, Lin Wang, Hui Guo, Leisheng Shi, Kun Zhang, Meina Tang, Shanshan Hu, Shanshan Dong, Yanling Liu, Tianyun Wang, Ping Yu, Xin He, Zhengmao Hu, Jinping Zhao, Chunyu Liu, Zhong Sheng Sun, Kun Xia
Autism spectrum disorder (ASD) represents a set of complex neurodevelopmental disorders with large degrees of heritability and heterogeneity. We sequenced 136 microcephaly or macrocephaly (Mic-Mac)-related genes and 158 possible ASD-risk genes in 536 Chinese ASD probands and detected 22 damaging de novo mutations (DNMs) in 20 genes, including CHD8 and SCN2A, with recurrent events. Nine of the 20 genes were previously reported to harbor DNMs in ASD patients from other populations, while 11 of them were first identified in present study...
September 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28829657/association-of-catalase-polymorphisms-with-primary-open-angle-glaucoma-in-a-chinese-population
#19
Bo Gong, Yi Shi, Chao Qu, Zimeng Ye, Yilin Yin, Chang Tan, Ping Shuai, Jing Li, Xiaoxin Guo, Yilian Cheng, Zhenglin Yang, Ying Lin, Xiaoqi Liu
PURPOSE: Many genes have been associated with primary open-angle glaucoma (POAG). This study was conducted to investigate whether catalase (CAT) polymorphisms play a significant role in POAG in a Chinese population. METHODS: A cohort of 416 unrelated POAG patients and 997 unrelated control subjects was included in this case-control association study. CAT functional single-nucleotide polymorphisms (SNPs), including rs1001179, rs7943316, and rs769217, were genotyped by SNaPshot method...
August 22, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28827521/dysivillosins-a-d-unusual-anti-allergic-meroterpenoids-from-the-marine-sponge-dysidea-villosa
#20
Wei-Hua Jiao, Bao-Hui Cheng, Guo-Hua Shi, Guo-Dong Chen, Bin-Bin Gu, Yong-Jun Zhou, Li-Li Hong, Fan Yang, Zhi-Qiang Liu, Shu-Qi Qiu, Zhi-Gang Liu, Ping-Chang Yang, Hou-Wen Lin
Four unusual meroterpenoids, dysivillosins A-D (1-4), were isolated from an organic extract of the marine sponge Dysidea villosa collected from the South China Sea. Their planar structures were determined by 1D and 2D NMR and HRESIMS techniques, while the relative and absolute configurations were elucidated by NOESY experiments and comparison between the calculated and experimental ECD spectra. To the best of our knowledge, dysivillosins A-D are the first examples of terpene-polyketide-pyridine hybrid metabolites from the nature...
August 21, 2017: Scientific Reports
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