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https://www.readbyqxmd.com/read/29777796/identification-of-a-sodium-pump-na-k-atpase-%C3%AE-1-targeted-peptide-for-pet-imaging-of-breast-cancer
#1
Qian Wang, Shi-Bing Li, Yi-Ying Zhao, Da-Nian Dai, Hui Du, Yan-Zhu Lin, Jia-Cong Ye, Jing Zhao, Wei Xiao, Yan Mei, Yi-Tai Xiao, Shi-Chu Liu, Yan Li, Yun-Fei Xia, Er-Wei Song, Gang-Hua Tang, Wei-Guang Zhang, Zhi-Jiang Li, Xiao-Bin Zheng, De-Hai Cao, Man-Zhi Li, Qian Zhong, Zhong-Ping Chen, Chao-Nan Qian, Wei Fan, Guo-Kai Feng, Mu-Sheng Zeng
The sodium pump Na+ /K+ ATPase a1 subunit(NKA a1), an attractive cancer-related biomarker and therapeutic target, is closely related to the development and progression of several cancers including breast cancer. Currently, a NKA a1 inhibitor, UNBS1450, has already evidenced its great therapeutic potential in personalized cancer treatment. The ability of non-invasive imaging of NKA a1 expression would be useful for selecting cancer patients who may benefit from this drug. Here, we identified an S3 peptide that is specifically homed to breast cancer by phage display...
May 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29775904/biosynthesis-of-chiral-epichlorohydrin-using-an-immobilized-halohydrin-dehalogenase-in-aqueous-and-non-aqueous-phase
#2
Xiao-Jian Zhang, Ping-Xiu Shi, Han-Zhong Deng, Xin-Xin Wang, Zhi-Qiang Liu, Yu-Guo Zheng
Asymmetric synthesis of chiral epichlorohydrin (ECH) from 1,3-dichloro-2-propanol (1,3-DCP) using halohydrin dehalogenase (HHDH) is of great value due to the 100% theoretical yield and high enantioselectivity. In this study, HheC (P175S/W249P) was immobilized on an A502Ps resin and used for the preparation of (S)-ECH. In aqueous system, the immobilized HheC catalyzed the biosynthesis of (S)-ECH with 83.78% yield and 92.53% enantiomeric excess (ee) at 1,3-DCP concentration of 20 mM. The non-aqueous system was further developed using water saturated ethyl acetate as solvent and reaction phase...
May 8, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29748863/repaglinide-irbesartan-drug-interaction-effects-of-slco1b1-polymorphism-on-repaglinide-pharmacokinetics-and-pharmacodynamics-in-chinese-population
#3
Qi Pei, Jun-Yan Liu, Ji-Ye Yin, Guo-Ping Yang, Shi-Kun Liu, Yi Zheng, Pan Xie, Cheng-Xian Guo, Mi Luo, Hong-Hao Zhou, Xi Li, Zhao-Qian Liu
PURPOSE: On account of the potential inhibition of OATP1B1 (organic anion transporting polypeptide) by angiotensin II receptor blockers (ARBs) and the effects of SLCO1B1 (solute carrier organic anion transporter family member) polymorphism, the aim of current study is to assess the impact of ARBs on the pharmacokinetics (PK) and pharmacodynamics (PD) of repaglinide in Chinese healthy volunteers with different SLCO1B1 genotypes. METHODS: The in vitro study was conducted on irbesartan, valsartan, olmesartan, and losartan by using HEK293 cells transfected with OATP1B1...
May 11, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29748761/gene-expression-in-triple-negative-breast-cancer-in-relation-to-survival
#4
Shuyang Wang, Alicia Beeghly-Fadiel, Qiuyin Cai, Hui Cai, Xingyi Guo, Liang Shi, Jie Wu, Fei Ye, Qingchao Qiu, Ying Zheng, Wei Zheng, Ping-Ping Bao, Xiao-Ou Shu
PURPOSE: The identification of biomarkers related to the prognosis of triple-negative breast cancer (TNBC) is critically important for improved understanding of the biology that drives TNBC progression. METHODS: We evaluated gene expression in total RNA isolated from formalin-fixed paraffin-embedded tumor samples using the NanoString nCounter assay for 469 TNBC cases from the Shanghai Breast Cancer Survival Study. We used Cox regression to quantify Hazard Ratios (HR) and corresponding confidence intervals (CI) for overall survival (OS) and disease-free survival (DFS) in models that included adjustment for breast cancer intrinsic subtype...
May 10, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29731619/association-between-a-frailty-index-based-on-common-laboratory-tests-and-qtc-prolongation-in-older-adults-the-rugao-longevity-and-ageing-study
#5
Teng Ma, Jian Cai, Yin-Sheng Zhu, Xue-Feng Chu, Yong Wang, Guo-Ping Shi, Zheng-Dong Wang, Shun Yao, Xiao-Feng Wang, Xiao-Yan Jiang
Background: Risk factors for heart rate-corrected QT interval (QTc) proglongation should be explored to stratify high-risk individuals to aid the prevention of incident cardiovascular events and mortality. The diversity of risk factors for QTc prolongation suggests that use of the frailty index (FI), indicating general health deficits, may be an effective approach, especially in the elderly, to identify the risk of QTc prolongation. Methods: We used the data of 1,780 individuals aged 70-87 years from the Rugao Longevity and Ageing Study (RuLAS), a community-based longitudinal study...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29713467/cerebral-glucose-metabolic-prediction-from-amnestic-mild-cognitive-impairment-to-alzheimer-s-dementia-a-meta-analysis
#6
REVIEW
Hai Rong Ma, Li Qin Sheng, Ping Lei Pan, Gen Di Wang, Rong Luo, Hai Cun Shi, Zhen Yu Dai, Jian Guo Zhong
Brain 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been utilized to monitor disease conversion from amnestic mild cognitive impairment (aMCI) to Alzheimer's dementia (AD). However, the conversion patterns of FDG-PET metabolism across studies are not conclusive. We conducted a voxel-wise meta-analysis using Seed-based d Mapping that included 10 baseline voxel-wise FDG-PET comparisons between 93 aMCI converters and 129 aMCI non-converters from nine longitudinal studies. The most robust and reliable metabolic alterations that predicted conversion from aMCI to AD were localized in the left posterior cingulate cortex (PCC)/precuneus...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29713173/significant-association-of-bdnf-rs6265-g-a-polymorphism-with-susceptibility-to-epilepsy-a-meta-analysis
#7
Yue-Long Xu, Xiu-Xiu Li, Su-Jing Zhuang, Shi-Feng Guo, Jian-Ping Xiang, Long Wang, Lan Zhou, Bin Wu
Introduction: Previously published articles have suggested that BDNF rs6265 G>A polymorphism is a potential risk factor for epilepsy. However, the results were not consistent. Methods: We conducted a meta-analysis to explore the association between BDNF rs6265 G>A polymorphism and epilepsy risk. Four online databases were searched, and related studies were reviewed from their inception up to June 20, 2017. ORs and corresponding 95% CIs were used to calculate the associations of each genetic model...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29707234/crispr-cas12a-assisted-nucleic-acid-detection
#8
Shi-Yuan Li, Qiu-Xiang Cheng, Jing-Man Wang, Xiao-Yan Li, Zi-Long Zhang, Song Gao, Rui-Bing Cao, Guo-Ping Zhao, Jin Wang
No abstract text is available yet for this article.
2018: Cell Discovery
https://www.readbyqxmd.com/read/29700006/erratum-for-fang-et-al-high-genetic-plasticity-in-multidrug-resistant-sequence-type-3-inchi2-plasmids-revealed-by-sequence-comparison-and-phylogenetic-analysis
#9
Liang-Xing Fang, Xing-Ping Li, Guo-Hui Deng, Shu-Min Li, Run-Shi Yang, Zuo-Wei Wu, Xiao-Ping Liao, Jian Sun, Ya-Hong Liu
No abstract text is available yet for this article.
May 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29696820/genetic-correction-of-serum-afp-level-improves-risk-prediction-of-primary-hepatocellular-carcinoma-in-the-dongfeng-tongji-cohort-study
#10
Ke Wang, Yansen Bai, Shi Chen, Jiao Huang, Jing Yuan, Weihong Chen, Ping Yao, Xiaoping Miao, Youjie Wang, Yuan Liang, Xiaomin Zhang, Meian He, Handong Yang, Huan Guo, Sheng Wei
Serum alpha-fetoprotein (AFP) is the most commonly used tumor biomarker for screening and diagnosis of primary hepatocellular carcinoma (HCC). However, the predictive effect for HCC risk is still unsatisfactory. The aim of this prospective study was to estimate whether the individual genetic correction could improve the prediction efficiency of AFP for HCC risk. A prospective analysis with 9819 baseline HCC-free individuals based on a large population-based Chinese cohort study was performed. Two single-nucleotide polymorphisms (SNPs) associated with serum AFP level were used to calculate the genetic corrected AFP level (rs12506899 and rs2251844)...
April 25, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29694170/precision-measurement-of-the-e-e-%C3%A2-%C3%AE-_-c-%C3%AE-over-%C3%A2-_-c-cross-section-near-threshold
#11
M Ablikim, M N Achasov, S Ahmed, M Albrecht, M Alekseev, A Amoroso, F F An, Q An, J Z Bai, Y Bai, O Bakina, R Baldini Ferroli, Y Ban, K Begzsuren, D W Bennett, J V Bennett, N Berger, M Bertani, D Bettoni, F Bianchi, E Boger, I Boyko, R A Briere, H Cai, X Cai, O Cakir, A Calcaterra, G F Cao, S A Cetin, J Chai, J F Chang, G Chelkov, G Chen, H S Chen, J C Chen, M L Chen, P L Chen, S J Chen, X R Chen, Y B Chen, X K Chu, G Cibinetto, F Cossio, H L Dai, J P Dai, A Dbeyssi, D Dedovich, Z Y Deng, A Denig, I Denysenko, M Destefanis, F De Mori, Y Ding, C Dong, J Dong, L Y Dong, M Y Dong, Z L Dou, S X Du, P F Duan, J Fang, S S Fang, Y Fang, R Farinelli, L Fava, S Fegan, F Feldbauer, G Felici, C Q Feng, E Fioravanti, M Fritsch, C D Fu, Q Gao, X L Gao, Y Gao, Y G Gao, Z Gao, B Garillon, I Garzia, A Gilman, K Goetzen, L Gong, W X Gong, W Gradl, M Greco, M H Gu, Y T Gu, A Q Guo, R P Guo, Y P Guo, A Guskov, Z Haddadi, S Han, X Q Hao, F A Harris, K L He, X Q He, F H Heinsius, T Held, Y K Heng, T Holtmann, Z L Hou, H M Hu, J F Hu, T Hu, Y Hu, G S Huang, J S Huang, X T Huang, X Z Huang, Z L Huang, T Hussain, W Ikegami Andersson, Q Ji, Q P Ji, X B Ji, X L Ji, X S Jiang, X Y Jiang, J B Jiao, Z Jiao, D P Jin, S Jin, Y Jin, T Johansson, A Julin, N Kalantar-Nayestanaki, X S Kang, M Kavatsyuk, B C Ke, T Khan, A Khoukaz, P Kiese, R Kliemt, L Koch, O B Kolcu, B Kopf, M Kornicer, M Kuemmel, M Kuhlmann, A Kupsc, W Kühn, J S Lange, M Lara, P Larin, L Lavezzi, H Leithoff, C Li, Cheng Li, D M Li, F Li, F Y Li, G Li, H B Li, H J Li, J C Li, J W Li, Jin Li, K J Li, Kang Li, Ke Li, Lei Li, P L Li, P R Li, Q Y Li, W D Li, W G Li, X L Li, X N Li, X Q Li, Z B Li, H Liang, Y F Liang, Y T Liang, G R Liao, J Libby, C X Lin, D X Lin, B Liu, B J Liu, C X Liu, D Liu, F H Liu, Fang Liu, Feng Liu, H B Liu, H L Liu, H M Liu, Huanhuan Liu, Huihui Liu, J B Liu, J Y Liu, K Liu, K Y Liu, Ke Liu, L D Liu, Q Liu, S B Liu, X Liu, Y B Liu, Z A Liu, Zhiqing Liu, Y F Long, X C Lou, H J Lu, J G Lu, Y Lu, Y P Lu, C L Luo, M X Luo, X L Luo, S Lusso, X R Lyu, F C Ma, H L Ma, L L Ma, M M Ma, Q M Ma, T Ma, X N Ma, X Y Ma, Y M Ma, F E Maas, M Maggiora, Q A Malik, Y J Mao, Z P Mao, S Marcello, Z X Meng, J G Messchendorp, G Mezzadri, J Min, R E Mitchell, X H Mo, Y J Mo, C Morales Morales, N Yu Muchnoi, H Muramatsu, A Mustafa, Y Nefedov, F Nerling, I B Nikolaev, Z Ning, S Nisar, S L Niu, X Y Niu, S L Olsen, Q Ouyang, S Pacetti, Y Pan, M Papenbrock, P Patteri, M Pelizaeus, J Pellegrino, H P Peng, Z Y Peng, K Peters, J Pettersson, J L Ping, R G Ping, A Pitka, R Poling, V Prasad, H R Qi, M Qi, T Y Qi, S Qian, C F Qiao, N Qin, X S Qin, Z H Qin, J F Qiu, K H Rashid, C F Redmer, M Richter, M Ripka, M Rolo, G Rong, Ch Rosner, A Sarantsev, M Savrié, C Schnier, K Schoenning, W Shan, X Y Shan, M Shao, C P Shen, P X Shen, X Y Shen, H Y Sheng, X Shi, J J Song, W M Song, X Y Song, S Sosio, C Sowa, S Spataro, G X Sun, J F Sun, L Sun, S S Sun, X H Sun, Y J Sun, Y K Sun, Y Z Sun, Z J Sun, Z T Sun, Y T Tan, C J Tang, G Y Tang, X Tang, I Tapan, M Tiemens, B Tsednee, I Uman, G S Varner, B Wang, B L Wang, D Wang, D Y Wang, Dan Wang, K Wang, L L Wang, L S Wang, M Wang, Meng Wang, P Wang, P L Wang, W P Wang, X F Wang, Y Wang, Y D Wang, Y F Wang, Y Q Wang, Z Wang, Z G Wang, Z Y Wang, Zongyuan Wang, T Weber, D H Wei, J H Wei, P Weidenkaff, S P Wen, U Wiedner, M Wolke, L H Wu, L J Wu, Z Wu, L Xia, Y Xia, D Xiao, Y J Xiao, Z J Xiao, Y G Xie, Y H Xie, X A Xiong, Q L Xiu, G F Xu, J J Xu, L Xu, Q J Xu, Q N Xu, X P Xu, F Yan, L Yan, W B Yan, W C Yan, Y H Yan, H J Yang, H X Yang, L Yang, Y H Yang, Y X Yang, Yifan Yang, M Ye, M H Ye, J H Yin, Z Y You, B X Yu, C X Yu, J S Yu, C Z Yuan, Y Yuan, A Yuncu, A A Zafar, Y Zeng, Z Zeng, B X Zhang, B Y Zhang, C C Zhang, D H Zhang, H H Zhang, H Y Zhang, J Zhang, J L Zhang, J Q Zhang, J W Zhang, J Y Zhang, J Z Zhang, K Zhang, L Zhang, S Q Zhang, X Y Zhang, Y Zhang, Y H Zhang, Y T Zhang, Yang Zhang, Yao Zhang, Yu Zhang, Z H Zhang, Z P Zhang, Z Y Zhang, G Zhao, J W Zhao, J Y Zhao, J Z Zhao, Lei Zhao, Ling Zhao, M G Zhao, Q Zhao, S J Zhao, T C Zhao, Y B Zhao, Z G Zhao, A Zhemchugov, B Zheng, J P Zheng, Y H Zheng, B Zhong, L Zhou, Q Zhou, X Zhou, X K Zhou, X R Zhou, X Y Zhou, A N Zhu, J Zhu, K Zhu, K J Zhu, S Zhu, S H Zhu, X L Zhu, Y C Zhu, Y S Zhu, Z A Zhu, J Zhuang, B S Zou, J H Zou
The cross section of the e^{+}e^{-}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} process is measured with unprecedented precision using data collected with the BESIII detector at sqrt[s]=4574.5, 4580.0, 4590.0 and 4599.5 MeV. The nonzero cross section near the Λ_{c}^{+}Λ[over ¯]_{c}^{-} production threshold is cleared. At center-of-mass energies sqrt[s]=4574.5 and 4599.5 MeV, the higher statistics data enable us to measure the Λ_{c} polar angle distributions. From these, the Λ_{c} electric over magnetic form-factor ratios (|G_{E}/G_{M}|) are measured for the first time...
March 30, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29684816/gaba-regulates-the-proliferation-and-apoptosis-of-mac-t-cells-through-the-lps-induced-tlr4-signaling-pathway
#12
Yue-Ying Wang, Shi-Ping Sun, He-Shui Zhu, Xian-Qin Jiao, Kai Zhong, Yu-Jie Guo, Guang-Ming Zha, Li-Qiang Han, Guo-Yu Yang, He-Ping Li
Subacute ruminal acidosis (SARA) can cause rapid lipopolysaccharide (LPS) elevation and milk yield decline in lactating ruminants. LPS has been shown to promote apoptosis and reduce the proliferation of mammary epithelial cells. Previous studies have shown that γ- amino butyric acid (GABA) can enhance production performance, regulating β-cell apoptosis and proliferation. Whether GABA can regulate apoptosis and proliferation induced by LPS in mammary epithelial cells is unknown. In this paper, we detected the role of GABA on proliferation and apoptosis as well as inflammation induced by LPS in bovine mammary epithelial cells (MAC-T cell line)...
April 18, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29684746/the-bioenergetics-mechanisms-and-applications-of-sulfate-reducing-bacteria-in-remediation-of-pollutants-in-drainage-a-review
#13
REVIEW
Xin Li, Shi-Ming Lan, Zhong-Ping Zhu, Chang Zhang, Guang-Ming Zeng, Yun-Guo Liu, Wei-Cheng Cao, Biao Song, Hong Yang, Sheng-Fan Wang, Shao-Hua Wu
Sulfate-reducing bacteria (SRB), a group of anaerobic prokaryotes, can use sulfur species as a terminal electron acceptor for the oxidation of organic compounds. They not only have significant ecological functions, but also play an important role in bioremediation of contaminated sites. Although numerous studies on metabolism and applications of SRB have been conducted, they still remain incompletely understood and even controversial. Fully understanding the metabolism of SRB paves the way for allowing the microorganisms to provide more beneficial services in bioremediation...
April 20, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29679024/cysteine-protease-cathepsins-in-cardiovascular-disease-from-basic-research-to-clinical-trials
#14
REVIEW
Cong-Lin Liu, Junli Guo, Xian Zhang, Galina K Sukhova, Peter Libby, Guo-Ping Shi
Cysteine protease cathepsins have traditionally been considered as lysosome-restricted proteases that mediate proteolysis of unwanted proteins. However, studies from the past decade demonstrate that these proteases are localized not only in acidic compartments (endosomes and lysosomes), where they participate in intracellular protein degradation, but also in the extracellular milieu, plasma membrane, cytosol, nucleus, and nuclear membrane, where they mediate extracellular matrix protein degradation, cell signalling, and protein processing and trafficking through the plasma and nuclear membranes and between intracellular organelles...
April 20, 2018: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29676187/decrease-of-ryr2-in-the-prion-infected-cell-line-and-in-the-brains-of-the-scrapie-infected-mice-models-and-the-patients-of-human-prion-diseases
#15
Qi Shi, Jian-Le Li, Yue Ma, Li-Ping Gao, Kang Xiao, Jing Wang, Wei Zhou, Cao Chen, Yan-Jun Guo, Xiao-Ping Dong
The levels of ryanodine receptors (RyRs) are usually increased in the brains of human Alzheimer disease (AD) and AD animal models. To evaluate the underlying alteration of brain RyRs in prion disease, scrapie infected cell line SMB-S15 and its infected mice were tested. RyR2 specific Western blots revealed markedly decreased RyR2 levels both in the cells and in the brains of infected mice. Assays of the brain samples of other scrapie (agents 139A and ME7) infected mice collected at different time-points during incubation period showed time-dependent decreases of RyR2...
April 20, 2018: Prion
https://www.readbyqxmd.com/read/29676133/-psoralen-inhibits-raw264-7-differentiation-into-osteoclasts-and-bone-resorption-by-regulating-cd4-t-cell-differentiation
#16
Jin-Ping Li, Bao-Ping Xie, Wen-Juan Zhang, Li-Ying Shi, Wei-Juan Li, Ying Zeng, Guo-Xing Gan, Yu-Hong Li
This paper aimed to investigate whether psoralen inhibits the differentiation and bone resorption by regulating CD4+T cell differentiation in RANKL-induced osteoclastogenesis in RAW264.7 cells, and elucidate its mechanism for osteoporosis. CD4+T cells were isolated from spleen cells of Balb/c mice by immunomagnetic separation method. The cells were divided into blank control group and psoralen group. The cells were cultured in 24-well plates and cultured for 3 days, and then they were collected for co-culture experiments after 4 days...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29670684/uva-irradiation-enhances-brusatol-mediated-inhibition-of-melanoma-growth-by-downregulation-of-the-nrf2-mediated-antioxidant-response
#17
Mei Wang, Guangwei Shi, Chunxiang Bian, Muhammad Farrukh Nisar, Yingying Guo, Yan Wu, Wei Li, Xiao Huang, Xuemei Jiang, Jörg W Bartsch, Ping Ji, Julia Li Zhong
Brusatol (BR) is a potent inhibitor of Nrf2, a transcription factor that is highly expressed in cancer tissues and confers chemoresistance. UVA-generated reactive oxygen species (ROS) can damage both normal and cancer cells and may be of potential use in phototherapy. In order to provide an alternative method to treat the aggressive melanoma, we sought to investigate whether low-dose UVA with BR is more effective in eliminating melanoma cells than the respective single treatments. We found that BR combined with UVA led to inhibition of A375 melanoma cell proliferation by cell cycle arrest in the G1 phase and triggers cell apoptosis...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29667617/combination-of-stromal-vascular-fraction-and-ad-comp-ang1-gene-therapy-improves-long-term-therapeutic-efficacy-for-diabetes-induced-erectile-dysfunction
#18
Guo-Nan Yin, Lin Wang, Xiang-Nan Lin, Lei Shi, Zhen-Lin Gao, Feng-Chan Han, Ping Li, Yin-Chuan Jin, Jun-Kyu Suh, Ji-Kan Ryu, Xiong Wang, Hai-Rong Jin
Men with diabetic erectile dysfunction (ED) respond poorly to the currently available oral phosphodiesterase-5 inhibitors. Therefore, functional therapies for diabetic ED are needed. Stromal vascular fraction (SVF) and the adenovirus-mediated cartilage oligomeric matrix angiopoietin-1 (Ad-COMP-Ang1) gene are known to play critical roles in penile erection. We previously reported that SVF and Ad-COMP-Ang1 have only a short-term effect in restoring erectile function. Further improvements to ED therapy are needed for long-lasting effects...
April 17, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29667327/novel-west-syndrome-candidate-genes-in-a-chinese-cohort
#19
Jing Peng, Ying Wang, Fang He, Chen Chen, Li-Wen Wu, Li-Fen Yang, Yu-Ping Ma, Wen Zhang, Zi-Qing Shi, Chao Chen, Kun Xia, Hui Guo, Fei Yin, Nan Pang
AIMS: West syndrome (WS) is a classic form of early infantile epileptic encephalopathy (EIEE) characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on electroencephalography. Genetic defects play a critical role in the pathology of WS, and 54 EIEE genes have been identified till date. This study was designed to uncover new candidate genes for West syndrome. METHODS: In this study, we recruited 56 Chinese families with WS of unknown etiology...
April 17, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29624802/serum-hepatitis-b-surface-antigen-correlates-with-fibrosis-and-necroinflammation-a-multicentre-perspective-in-china
#20
Zhang Peng, Du Hong-Bo, Tong Guang-Dong, Li Xiao-Ke, Sun Xue-Hua, Chi Xiao-Ling, Xing Yu-Feng, Zhou Zhen-Hua, Li Qin, Chen Bin, Wang Hui, Wang Li, Jin Hua, Mao De-Wen, Wang Xian-Bo, Wu Qi-Kai, Li Fen-Ping, Hu Xiao-Yu, Lu Bing-Jiu, Yang Zhi-Yun, Zhang Ming-Xiang, Shi Wei-Bing, He Qing, Li Yong, Jiang Kai-Ping, Xue Jing-Dong, Li Xiao-Dong, Jiang Jun-Min, Lu Wei, Tian Guang-Jun, Hu Zhen-Bin, Guo Jian-Chun, Li Cheng-Zhong, Deng Xin, Luo Xin-la, Li Feng-Yi, Zhang Xin-Wei, Zheng Ying-Jun, Zhao Gang, Wang Li-Chun, Wu Jian-Hua, Guo Hui, Mi Yu-Qiang, Gong Zuo-Jiong, Wang Cheng-Bao, Jiang Feng, Guo Peng, Yang Xian-Zhao, Shi Wei-Qun, Yang Hong-Zhi, Zhou Yong, Sun Ning-Ning, Jiao Yun-Tao, Gao Yue-Qiu, Zhou Da-Qiao, Ye Yong-An
The kinetics of serum hepatitis B surface antigen (HBsAg) during the natural history of hepatitis B virus (HBV) infection has been studied, but the factors affecting them remain unclear. AIMS: We aimed to investigate the factors affecting HBsAg titers, using data from multi-center, large-sized clinical trials in China. The baseline data of 1,795 patients in three multi-center trials were studied, and the patients were classified into three groups: hepatitis B early antigen (HBeAg)-positive chronic HBV infection (n=588), HBeAg-positive chronic hepatitis B (n=596), and HBeAg-negative chronic hepatitis B (n=611)...
April 6, 2018: Journal of Viral Hepatitis
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