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https://www.readbyqxmd.com/read/28425483/a-genome-wide-association-study-identifies-six-novel-risk-loci-for-primary-biliary-cholangitis
#1
Fang Qiu, Ruqi Tang, Xianbo Zuo, Xingjuan Shi, Yiran Wei, Xiaodong Zheng, Yaping Dai, Yuhua Gong, Lan Wang, Ping Xu, Xiang Zhu, Jian Wu, Chongxu Han, Yueqiu Gao, Kui Zhang, Yuzhang Jiang, Jianbo Zhou, Youlin Shao, Zhigang Hu, Ye Tian, Haiyan Zhang, Na Dai, Lei Liu, Xudong Wu, Weifeng Zhao, Xiaomin Zhang, Zhidong Zang, Jinshan Nie, Weihao Sun, Yi Zhao, Yuan Mao, Po Jiang, Hualiang Ji, Qing Dong, Junming Li, Zhenzhong Li, Xinli Bai, Li Li, Maosong Lin, Ming Dong, Jinxin Li, Ping Zhu, Chan Wang, Yanqiu Zhang, Peng Jiang, Yujue Wang, Rohil Jawed, Jing Xu, Yu Zhang, Qixia Wang, Yue Yang, Fan Yang, Min Lian, Xiang Jiang, Xiao Xiao, Yanmei Li, Jingyuan Fang, Dekai Qiu, Zhen Zhu, Hong Qiu, Jianqiong Zhang, Wenyan Tian, Sufang Chen, Ling Jiang, Bing Ji, Ping Li, Guochang Chen, Tianxue Wu, Yan Sun, Jianjiang Yu, Huijun Tang, Michun He, Min Xia, Hao Pei, Lihua Huang, Zhuye Qing, Jianfang Wu, Qinghai Huang, Junhai Han, Wei Xie, Zhongsheng Sun, Jian Guo, Gengsheng He, M Eric Gershwin, Zhexiong Lian, Xiang Liu, Michael F Seldin, Xiangdong Liu, Weichang Chen, Xiong Ma
Primary biliary cholangitis (PBC) is an autoimmune liver disease with a strong hereditary component. Here, we report a genome-wide association study that included 1,122 PBC cases and 4,036 controls of Han Chinese descent, with subsequent replication in a separate cohort of 907 PBC cases and 2,127 controls. Our results show genome-wide association of 14 PBC risk loci including previously identified 6p21 (HLA-DRA and DPB1), 17q12 (ORMDL3), 3q13.33 (CD80), 2q32.3 (STAT1/STAT4), 3q25.33 (IL12A), 4q24 (NF-κB) and 22q13...
April 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28423488/mmp8-polymorphism-is-associated-with-susceptibility-to-osteonecrosis-of-the-femoral-head-in-a-chinese-han-population
#2
Feimeng An, Jieli Du, Yuju Cao, Jianping Shi, Yongchang Guo, Tianbo Jin, Jian Li, Junyu Chen, Ping Li, Mei Dong, Guoqiang Wang, Jianzhong Wang
Osteonecrosis of the femoral head (ONFH) is an orthopedic refractory disease that adversely affects quality of life. Matrix metalloproteinase-8 (MMP-8) produced by the bone marrow has been implicated in the degradation of collagen during bone development. We assessed whether MMP8 polymorphisms are associated with ONFH. In a case-control study, using χ2 tests and genetic model analyses, we genotyped 5 MMP8 single-nucleotide polymorphisms (SNPs) in 585 ONFH patients and 507 healthy control subjects in a Chinese Han population...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420811/the-t-allele-of-rs8075977-in-the-5-flanking-region-of-the-pedf-gene-is-associated-with-reduced-risk-of-coronary-artery-disease-in-elderly-chinese-men
#3
Shou-Yuan Ma, Yuan-Yuan Guo, Shu-Xia Wang, Jin-Xin Shi, Jie Liu, Jian-Feng Liu, Ping Zhu
Coronary artery disease (CAD) is a multifactorial disease with a genetic component. Pigment epithelium-derived factor (PEDF) exerts anti-inflammatory, anti-oxidant, anti-thrombotic, and anti-angiogenic effects and thus has received increasing attention as a sensitive biomarker of atherosclerosis and CAD. To explore the potential association between PEDF single nucleotide polymorphisms (SNPs) and CAD, we performed this case-control study of consecutive elderly Chinese Han male patients (n = 416) and age-matched male controls (n = 528) without a history of CAD or electrocardiographic signs of CAD...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28420134/visual-detection-and-tracking-system-for-a-spherical-amphibious-robot
#4
Shuxiang Guo, Shaowu Pan, Liwei Shi, Ping Guo, Yanlin He, Kun Tang
With the goal of supporting close-range observation tasks of a spherical amphibious robot, such as ecological observations and intelligent surveillance, a moving target detection and tracking system was designed and implemented in this study. Given the restrictions presented by the amphibious environment and the small-sized spherical amphibious robot, an industrial camera and vision algorithms using adaptive appearance models were adopted to construct the proposed system. To handle the problem of light scattering and absorption in the underwater environment, the multi-scale retinex with color restoration algorithm was used for image enhancement...
April 15, 2017: Sensors
https://www.readbyqxmd.com/read/28410220/reprogramming-induced-by-isoliquiritigenin-diminishes-melanoma-cachexia-through-mtorc2-akt-gsk3%C3%AE-signaling
#5
Xiao-Yu Chen, De-Fang Li, Ji-Chun Han, Bo Wang, Zheng-Ping Dong, Li-Na Yu, Zhao-Hai Pan, Chuan-Jun Qu, Ying Chen, Shi-Guo Sun, Qiu-Sheng Zheng
Isoliquiritigenin (ISL), a member of the flavonoids, is known to have anti-tumor activity in vitro and in vivo. The effect of ISL on reprogramming in cancer cells, however, remains elusive. In this study, we investigated the effect of ISL on reprogramming in human melanoma A375 cells. ISL (15 μg/ml) significantly inhibited A375 cell proliferation, anchorage independent cell proliferation and G2/M cell cycle arrest after ISL exposure for 24 h. However, there were no significant changes in apoptosis rate. Terminal differentiation indicators (melanin content, melanogenesis mRNA expression, tyrosinase (TYR) activity) were all up-regulated by ISL treatment...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28405790/csh-guidelines-for-the-diagnosis-and-treatment-of-drug-induced-liver-injury
#6
EDITORIAL
Yue-Cheng Yu, Yi-Min Mao, Cheng-Wei Chen, Jin-Jun Chen, Jun Chen, Wen-Ming Cong, Yang Ding, Zhong-Ping Duan, Qing-Chun Fu, Xiao-Yan Guo, Peng Hu, Xi-Qi Hu, Ji-Dong Jia, Rong-Tao Lai, Dong-Liang Li, Ying-Xia Liu, Lun-Gen Lu, Shi-Wu Ma, Xiong Ma, Yue-Min Nan, Hong Ren, Tao Shen, Hao Wang, Ji-Yao Wang, Tai-Ling Wang, Xiao-Jin Wang, Lai Wei, Qing Xie, Wen Xie, Chang-Qing Yang, Dong-Liang Yang, Yan-Yan Yu, Min-de Zeng, Li Zhang, Xin-Yan Zhao, Hui Zhuang
Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI is far more common than intrinsic DILI clinically and can be classified into hepatocellular injury, cholestatic injury, hepatocellular-cholestatic mixed injury, and vascular injury based on the types of injured target cells...
April 12, 2017: Hepatology International
https://www.readbyqxmd.com/read/28405010/toll-like-receptor-7-deficiency-protects-apolipoprotein-e-deficient-mice-from-diet-induced-atherosclerosis
#7
Cong-Lin Liu, Marcela M Santos, Cleverson Fernandes, Mengyang Liao, Karine Iamarene, Jin-Ying Zhang, Galina K Sukhova, Guo-Ping Shi
Toll-like receptor 7 (TLR7) mediates autoantigen and viral RNA-induced cytokine production. Increased TLR7 expression in human atherosclerotic lesions suggests its involvement in atherogenesis. Here we demonstrated TLR7 expression in macrophages, smooth muscle cells (SMCs), and endothelial cells from mouse atherosclerotic lesions. To test a direct participation of TLR7 in atherosclerosis, we crossbred TLR7-deficient (Tlr7 (-/-)) mice with apolipoprotein E-deficient (Apoe (-/-)) mice and produced Apoe (-/-) Tlr7 (-/-) and Apoe (-/-) Tlr7 (+/+) littermates, followed by feeding them an atherogenic diet to produce atherosclerosis...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28404919/paeonol-suppresses-solar-ultraviolet-induced-skin-inflammation-by-targeting-t-lak-cell-originated-protein-kinase
#8
Peipei Xue, Yong Wang, Fanfan Zeng, Ruijuan Xiu, Jingwen Chen, Jinguang Guo, Ping Yuan, Lin Liu, Juanjuan Xiao, Hui Lu, Dan Wu, Huaxiong Pan, Mingmin Lu, Feng Zhu, Fei Shi, Qiuhong Duan
Excessive exposure to solar UV (SUV) is related with numerous human skin disorders, such as skin inflammation, photoaging and carcinogenesis. T-LAK cell- originated protein kinase (TOPK), an upstream of p38 mitogen-activated protein kinase (p38) and c-Jun N-terminal kinases (JNKs), plays an important role in SUV -induced skin inflammation, and targeting TOPK has already been a strategy to prevent skin inflammation. In this study, we found that the expression of TOPK, phosphorylation of p38 or JNKs was increased in human solar dermatitis tissues...
February 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28382142/protein-regulator-of-cytokinesis-prc1-confers-chemoresistance-and-predicts-an-unfavorable-postoperative-survival-of-hepatocellular-carcinoma-patients
#9
Yu Wang, Feng Shi, Guo-Hui Xing, Ping Xie, Na Zhao, Yu-Feng Yin, Shu-Yan Sun, Jing He, Ying Wang, Shi-Ying Xuan
Background: PRC1, a microtubules(MTs)-associated protein, is essential in the mitosis and cell cycle regulation. It has been recently linked to chemoresistance and tumorigenesis. The current study sought to explore the role of PRC1 on chemoresistance and postoperative prognosis of hepatocellular carcinoma(HCC). Methods: PRC1 was transfected into HCC cells to detect its effects of chemoresistance to 5-fluorouracil in vitro and in vivo. This study also investigated the impact of PRC1 on 5-FU-induced G2/M phase arrest and the potential molecular mechanism...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28380458/co-expression-of-afap1-as1-and-pd-1-predicts-poor-prognosis-in-nasopharyngeal-carcinoma
#10
Yanyan Tang, Yi He, Lei Shi, Liting Yang, Jinpeng Wang, Yu Lian, Chunmei Fan, Ping Zhang, Can Guo, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Fang Xiong, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng
Nasopharyngeal carcinoma (NPC) carries a high potential for metastasis and immune escape, with a great risk of relapse after primary treatment. Through analysis of whole genome expression profiling data in NPC samples, we found that the expression of a long non-coding RNA (lncRNA), actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), is significantly correlated with the immune escape marker programmed death 1 (PD-1). We therefore assessed the expression of AFAP1-AS1 and PD-1 in a cohort of 96 paraffin-embedded NPC samples and confirmed that AFAP1-AS1 and PD-1 are co-expressed in infiltrating lymphocytes in NPC tissue...
March 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28365702/akt2-dependent-beneficial-effect-of-galanin-on-insulin-induced-glucose-uptake-in-adipocytes-of-diabetic-rats
#11
Zhenwen Zhang, Penghua Fang, Lili Guo, Biao He, Mingyi Shi, Yan Zhu, Ping Bo
BACKGROUND/AIMS: Glucose uptake occurs via the activation of an insulin-signaling cascade, resulting in the translocation of glucose transporter 4 (GLUT4) to the plasma membrane of adipocytes and myocytes. Recent research found that galanin could boost insulin-induced glucose uptake. This study aimed to explore whether activation of Akt2 mediates the beneficial effects of galanin on insulin-induced glucose uptake in the adipocytes of diabetic rats. METHOD: In this experiment, insulin, galanin and MK-2206, an Akt inhibitor, were injected individually or in combination into diabetic rats once a day for ten days...
March 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28365701/suppression-of-microrna-383-enhances-therapeutic-potential-of-human-bone-marrow-derived-mesenchymal-stem-cells-in-treating-spinal-cord-injury-via-gdnf
#12
Guo-Jun Wei, Gang An, Zuo-Wei Shi, Kai-Fu Wang, Ying Guan, Yan-Song Wang, Bo Han, En-Ming Yu, Peng-Fei Li, Da-Ming Dong, Li-Ping Wang, Zhao-Wei Teng, De-Lai Zhao
BACKGROUND/AIMS: Transplantation of bone-marrow-derived mesenchymal stem cells (MSCs) has been used to treat spinal cord injury (SCI) to enhance tissue repair and neural cell regeneration. Glial cell line derived neurotrophic factor (GDNF) is an identified neural growth and survival factor. Here, we examined whether modification of GDNF levels in MSCs may further increase the potential of MSCs in promoting neural cell regeneration and subsequently the therapeutic outcome. METHODS: We examined the mRNA and protein levels of GDNF in human MSCs by RT-qPCR and Western blot, respectively...
March 17, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28363574/corrigendum-to-antimicrobial-and-antioxidant-activities-of-flammulina-velutipes-polysacchrides-and-polysacchride-iron-iii-complex-carbohydrate-polymers-161-2017-26-32
#13
Ya-Ru Dong, Shu-Jie Cheng, Guo-Hong Qi, Zhi-Ping Yang, Shi-Yu Yin, Gui-Tang Chen
No abstract text is available yet for this article.
June 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28351030/a-comparison-of-different-training-methods-in-the-successful-learning-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#14
Wen Chao Zhang, Wei Chen, Jian Ping Zhou, Andrew D Lerner, Lei Ni, Ji Min Shen, Tian Li Yan, Min Zhou, Guo Chao Shi, Yi Xiang
BACKGROUND: Standardized training of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS- TBNA) is available only in highly developed countries. OBJECTIVE: To compare the skill differences in the performance of EBUS-TBNA by pulmonologists trained under different learning methods. METHODS: We performed a retrospective study of 145 EBUS-TBNA cases. We set up 3 comparative training groups: a standardized training group, a teaching group, and a self-study group...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28302420/a-cryptic-mitochondrial-dna-link-between-north-european-and-west-african-dogs
#15
Adeniyi C Adeola, Sheila C Ommeh, Jiao-Jiao Song, S Charles Olaogun, Oscar J Sanke, Ting-Ting Yin, Guo-Dong Wang, Shi-Fang Wu, Zhong-Yin Zhou, Jacqueline K Lichoti, Bernard R Agwanda, Philip M Dawuda, Robert W Murphy, Min-Sheng Peng, Ya-Ping Zhang
Domestic dogs have an ancient origin and a long history in Africa. Nevertheless, the timing and sources of their introduction into Africa remain enigmatic. Herein, we analyse variation in mitochondrial DNA (mtDNA) D-loop sequences from 345 Nigerian and 37 Kenyan village dogs plus 1530 published sequences of dogs from other parts of Africa, Europe and West Asia. All Kenyan dogs can be assigned to one of three haplogroups (matrilines; clades): A, B, and C, while Nigerian dogs can be assigned to one of four haplogroups A, B, C, and D...
March 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28297576/chitosan-wound-dressings-incorporating-exosomes-derived-from-microrna-126-overexpressing-synovium-mesenchymal-stem-cells-provide-sustained-release-of-exosomes-and-heal-full-thickness-skin-defects-in-a-diabetic-rat-model
#16
Shi-Cong Tao, Shang-Chun Guo, Min Li, Qin-Fei Ke, Ya-Ping Guo, Chang-Qing Zhang
There is a need to find better strategies to promote wound healing, especially of chronic wounds, which remain a challenge. We found that synovium mesenchymal stem cells (SMSCs) have the ability to strongly promote cell proliferation of fibroblasts; however, they are ineffective at promoting angiogenesis. Using gene overexpression technology, we overexpressed microRNA-126-3p (miR-126-3p) and transferred the angiogenic ability of endothelial progenitor cells to SMSCs, promoting angiogenesis. We tested a therapeutic strategy involving controlled-release exosomes derived from miR-126-3p-overexpressing SMSCs combined with chitosan...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28262375/impact-of-osmoregulation-on-the-differences-in-cd-accumulation-between-two-contrasting-edible-amaranth-cultivars-grown-on-cd-polluted-saline-soils
#17
Zhi-Min Xu, Qu-Sheng Li, Ping Yang, Han-Jie Ye, Zi-Shuo Chen, Shi-Hong Guo, Li-Li Wang, Bao-Yan He, Eddy Y Zeng
This study aimed to investigate the difference of osmoregulation between two edible amaranth cultivars, Liuye (high Cd accumulator) and Quanhong (low Cd accumulator), under salinity stress and determine the effects of such difference on Cd accumulation. A pot experiment was conducted to expose the plants to sewage-irrigated garden soil (mean 2.28 mg kg(-1) Cd) pretreated at three salinity levels. Under salinity stress, the concentrations of Cd in the two cultivars were significantly elevated compared with those in the controls, and the Cd concentration in Liuye was statistically higher than that in Quanhong (p < 0...
March 2, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28261712/ruthenium-nitrosyl-functionalized-graphene-quantum-dots-as-an-efficient-nanoplatform-for-nir-light-controlled-and-mitochondria-targeted-delivery-of-nitric-oxide-combined-with-photothermal-therapy
#18
Min Guo, Hui-Jing Xiang, Yi Wang, Qian-Ling Zhang, Lu An, Shi-Ping Yang, Yinchu Ma, Yucai Wang, Jin-Gang Liu
A mitochondria-targeting nanoplatform for near-infrared-light-controlled release of nitric oxide accompanied by photothermal therapy was developed, which consists of ruthenium nitrosyl functionalized N-doped graphene quantum dots and a triphenylphosphonium moiety. The nanoplatform demonstrated both in vitro and in vivo anti-tumor efficacy upon irradiation with 808 nm light.
March 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28257845/an-efficient-system-for-deletion-of-large-dna-fragments-in-escherichia-coli-via-introduction-of-both-cas9-and-the-non-homologous-end-joining-system-from-mycobacterium-smegmatis
#19
Xuan Zheng, Shi-Yuan Li, Guo-Ping Zhao, Jin Wang
Accompanied with the internal non-homologous end joining (NHEJ) system, Cas9 can be used to easily inactivate a gene or delete a fragment through introduction of DNA double-stranded breaks (DSBs) in eukaryotic cells. While in most prokaryotes (e.g. Escherichia coli), due to the lack of NHEJ, homologous recombination (HR) is required for repair of DSBs, which is less convenient. Here, a markerless system was developed for rapid gene inactivation or fragment deletion in E. coli via introduction of both Cas9 and a bacterial NHEJ system...
April 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28256400/amphiregulin-antibody-and-reduction-of-axial-elongation-in-experimental-myopia
#20
Wen Jun Jiang, Hui Xin Song, Shao Yu Li, Bin Guo, Jian Feng Wu, Guo Ping Li, Da Dong Guo, De Long Shi, Hong Sheng Bi, Jost B Jonas
To examine the mechanism of ocular axial elongation in myopia, guinea pigs (age: 2-3weeks) which either underwent unilateral or bilateral lens-induced myopization (group 1) or which were primarily myopic at baseline (group 2) received unilateral intraocular injections of amphiregulin antibody (doses: 5, 10, or 15μg) three times in intervals of 9days. A third group of emmetropic guinea pigs got intraocular unilateral injections of amphiregulin (doses: 0.25, 0.50 or 1.00ng, respectively). In each group, the contralateral eyes received intraocular injections of Ringer's solution...
March 2017: EBioMedicine
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