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https://www.readbyqxmd.com/read/28807096/a-five-year-surveillance-of-carbapenemase-producing-klebsiella-pneumoniae-in-a-pediatric-hospital-in-china-reveals-increased-predominance-of-ndm-1
#1
Fang Dong, Jie Lu, Yan Wang, Jin Shi, Jing Hui Zhen, Ping Chu, Yang Zhen, Shu Jing Han, Yong Li Guo, Wen Qi Song
OBJECTIVE: To characterize carbapenem (CPM)-non-susceptible Klebsiella pneumoniae (K. pneumoniae) and carbape-nemase produced by these strains isolated from Beijing Children's Hospital based on a five-year surveillance. METHODS: The Minimal Inhibition Concentration values for 15 antibiotics were assessed using the Phonix100 compact system. PCR amplification and DNA sequencing were used to detect genes encoding carbapenemases. WHONET 5.6 was finally used for resistance analysis...
August 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28798308/prognostic-value-of-programmed-cell-death-protein-1-expression-on-cd8-t-lymphocytes-in-pancreatic-cancer
#2
Tao Shen, Liangjing Zhou, Hua Shen, Chengfei Shi, Shengnan Jia, Guo Ping Ding, Liping Cao
Pancreatic cancer is one of the most aggressive malignancies and has a highly immunosuppressive tumour microenvironment. Immune checkpoint blockade has led to remarkable and durable objective responses in a number of malignancies and antibody-based strategies targeting programmed cell death protein 1 (PD-1) are showing promise where traditional modalities of surgery, radiotherapy, and chemotherapy have failed. In this study, we examined the clinical value of PD-1 protein expression by CD8+ peripheral T lymphocytes or tumour-infiltrating T lymphocytes (TILs) in pancreatic ductal adenocarcinoma (PDAC)...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28776692/brassinosteroid-mediated-apoplastic-h2-o2-glutaredoxin-12-14-cascade-regulates-antioxidant-capacity-in-response-to-chilling-in-tomato
#3
Xiao-Jian Xia, Ping-Ping Fang, Xie Guo, Xiang-Jie Qian, Jie Zhou, Kai Shi, Yan-Hong Zhou, Jing-Quan Yu
Brassinosteroids (BRs) regulate plant development and stress response. Although much has been learned about their roles in plant development, the mechanisms by which BRs regulate plant stress tolerance remain unclear. Chilling is a major stress that adversely affects plant growth. Here, we report that BR positively regulates chilling tolerance in tomato. BR partial deficiency aggravated chilling-induced oxidized protein accumulation, membrane lipid peroxidation and decrease of maximum quantum efficiency of photosystem II (Fv/Fm)...
August 4, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28767022/failure-patterns-and-prognostic-factors-of-patients-with-primary-mucosal-melanoma-of-the-nasal-cavity-and-paranasal-sinuses
#4
Zhi-Ping Liu, Jing-Wei Luo, Guo-Zhen Xu, Li Gao, Jun-Lin Yi, Xiao-Dong Huang, Yuan Qu, Kai Wang, Shi-Ping Zhang, Jian-Ping Xiao
OBJECTIVES: To analyse the failure patterns and prognostic factors influencing survival in patients with primary mucosal melanoma of the nasal cavity and paranasal sinuses. MATERIALS AND METHODS: Fifty-one patients were analysed retrospectively. Forty-eight, 33, 10, and 13 patients underwent surgery, radiotherapy, chemotherapy, and immunotherapy, respectively. Failure events, including local recurrence, regional relapse, distant metastases, and death, were examined...
October 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28765627/value-of-shear-wave-arrival-time-contour-display-in-shear-wave-elastography-for-breast-masses-diagnosis
#5
Bang-Guo Zhou, Dan Wang, Wei-Wei Ren, Xiao-Long Li, Ya-Ping He, Bo-Ji Liu, Qiao Wang, Shi-Gao Chen, Azra Alizad, Hui-Xiong Xu
To evaluate the diagnostic performance of shear wave arrival time contour (SWATC) display for the diagnosis of breast lesions and to identify factors associated with the quality of shear wave propagation (QSWP) in breast lesions. This study included 277 pathologically confirmed breast lesions. Conventional B-mode ultrasound characteristics and shear wave elastography parameters were computed. Using the SWATC display, the QSWP of each lesion was assigned to a two-point scale: score 1 (low quality) and score 2 (high quality)...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28765540/harvesting-more-grain-zinc-of-wheat-for-human-health
#6
Xin-Ping Chen, Yue-Qiang Zhang, Yi-Ping Tong, Yan-Fang Xue, Dun-Yi Liu, Wei Zhang, Yan Deng, Qing-Feng Meng, Shan-Chao Yue, Peng Yan, Zhen-Ling Cui, Xiao-Jun Shi, Shi-Wei Guo, Yi-Xiang Sun, You-Liang Ye, Zhao-Hui Wang, Liang-Liang Jia, Wen-Qi Ma, Ming-Rong He, Xi-Ying Zhang, Chang-Lin Kou, Yan-Ting Li, De-Shui Tan, Ismail Cakmak, Fu-Suo Zhang, Chun-Qin Zou
Increasing grain zinc (Zn) concentration of cereals for minimizing Zn malnutrition in two billion people represents an important global humanitarian challenge. Grain Zn in field-grown wheat at the global scale ranges from 20.4 to 30.5 mg kg(-1), showing a solid gap to the biofortification target for human health (40 mg kg(-1)). Through a group of field experiments, we found that the low grain Zn was not closely linked to historical replacements of varieties during the Green Revolution, but greatly aggravated by phosphorus (P) overuse or insufficient nitrogen (N) application...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28761410/correction-acupuncture-with-reinforcing-and-reducing-twirling-manipulation-inhibits-hippocampal-neuronal-apoptosis-in-spontaneously-hypertensive-rats
#7
Juan Lu, Yan Guo, Chang-Qing Guo, Xue-Min Shi, Ning-Yu Du, Rui-Li Zhao, Wen-Ping Du, Jing-Rong Liang, Shi-Peng Zhu, Huan Chen
[This corrects the article on p. 770 in vol. 12, PMID: 28616034.].
June 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28758393/gsh-activatable-nir-fluorescent-prodrug-for-podophyllotoxin-delivery
#8
Yajing Liu, Shaojia Zhu, Kaizhi Gu, Zhiqian Guo, Xiaoyu Huang, Ming-Wei Wang, Hesham M Amin, Wei-Hong Zhu, Ping Shi
Theranostic prodrug therapy enables the targeted delivery of anticancer drugs with minimized adverse effects and real-time in situ monitoring of activation of the prodrugs. In this work, we report the synthesis and biological assessment of the near-infrared (NIR) prodrug DCM-S-PPT and its amphiphilic copolymer (mPEG-DSPE)-encapsulated nanoparticles. DCM-S-PPT is composed of podophyllotoxin (PPT) as the anticancer moiety and a dicyanomethylene-4H-pyran (DCM) derivative as the NIR fluorescent reporter, which are linked by a thiol-specific cleavable disulfide bond...
July 31, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28745036/neutropenia-during-the-first-cycle-of-induction-chemotherapy-is-prognostic-for-poor-survival-in-locoregionally-advanced-nasopharyngeal-carcinoma-a-real-world-study-in-an-endemic-area
#9
Cheng Xu, Shi-Ping Yang, Yuan Zhang, Ling-Long Tang, Guan-Qun Zhou, Xu Liu, Yan-Ping Mao, Rui Guo, Wen-Fei Li, Lei Chen, Ai-Hua Lin, Ying Sun, Jun Ma
Purpose: The purpose of this study was to investigate the effect of neutropenia during the first cycle of induction chemotherapy (IC-1) on survival in locoregionally advanced nasopharyngeal carcinoma (LANPC). Materials and Methods: Eligible patients (n=545) with LANPC receiving IC+concurrent chemoradiotherapy were included. Based on nadir neutrophil after IC-1, all patients were categorized into three groups: no/grade 1-2/grade 3-4 neutropenia. Five-year overall survival (OS) and disease-free survival (DFS) were compared between groups and subgroups stratified by IC regimen...
July 24, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28717240/elemental-compositions-of-lichens-from-duolun-county-inner-mongolia-china-origin-road-effect-and-species-difference
#10
Hua-Jie Liu, Jing-Gong Wang, Yu Xia, Meng-Jie Yang, Si-Wa Liu, Liang-Cheng Zhao, Xiu-Ping Guo, Yun-Jun Jiang, Xin Li, Qing-Feng Wu, Shi-Bo Fang
To assess the response of lichen elemental compositions to road traffic and species difference in the context of high dust input and anthropogenic emissions, two foliose epiphytic lichens (Phaeophyscia hirtuosa, PHh; Candelaria fibrosa, CAf) were sampled near a road adjacent to Dolon Nor Town (Duolun County, Inner Mongolia, China). Twenty elements (Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Mo, Na, Ni, P, Pb, Sb, Sr, Ti, V and Zn) in lichen and surface soil samples were analysed using inductively coupled plasma mass spectrometer (ICP-MS)...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28706154/predictive-value-of-post-procedural-early-within-24-h-increase-in-cystatin-c-for-contrast-induced-acute-kidney-injury-and-mortality-following-coronary-angiography-or-intervention
#11
Yong Liu, Kai-Hong Chen, Shi-Qun Chen, Li-Ling Chen, Chong-Yang Duan, Kun Wang, Xiao-Sheng Guo, Hua-Long Li, Wei-Jie Bei, Kai-Yan Lin, Ping-Yan Chen, Ying Xian, Ning Tan, Ying-Ling Zhou, Qing-Shan Geng, Ji-Yan Chen
OBJECTIVE: To investigate the predictive value of post-procedural early (within 24 h) increase in cystatin C for contrast-induced acute kidney injury (CI-AKI) and all-cause mortality following coronary angiography or intervention. METHODS: We prospectively investigated 1042 consecutive patients with both baseline and early post-procedural cystatin C measurement undergoing coronary angiography or intervention. CI-AKI was defined as an increase ≥0.3 mg/dL or >50% in serum creatinine from baseline within 48 h post-procedure...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28702552/correction-a-new-aie-multi-block-polyurethane-copolymer-material-for-subcellular-microfilament-imaging-in-living-cells
#12
Yu-Qing Niu, Tao He, Jun Song, Si-Ping Chen, Xiang-Yu Liu, Zhi-Gang Chen, Ying-Jie Yu, Shi-Guo Chen
Correction for 'A new AIE multi-block polyurethane copolymer material for subcellular microfilament imaging in living cells' by Yu-qing Niu et al., Chem. Commun., 2017, DOI: .
July 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28697832/-efficacy-of-clonidine-transdermal-patch-in-treatment-of-moderate-to-severe-tic-disorders-in-children
#13
Jing-Min Guo, Xiao-Xi Shi, Shi-Wei Yang, Qin-Fang Qian, Yan Huang, Yan-Qin Xie, Ping Ou
OBJECTIVE: To investigate the difference in the efficacy between clonidine transdermal patch and haloperidol tablets in the treatment of moderate to severe tic disorders in children. METHODS: A total of 134 children with moderate to severe tic disorders were randomly divided into clonidine group (n=70) and haloperidol group (n=64). The clonidine and haloperidol groups were treated with clonidine transdermal patch and haloperidol tablets respectively, and the treatment lasted for 8 weeks in both groups...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28684781/characterization-of-transcriptional-modules-related-to-fibrosing-nafld-progression
#14
Yi Lou, Guo-Yan Tian, Yu Song, Yin-Lan Liu, Yi-Dan Chen, Jun-Ping Shi, Jin Yang
Based on the severity of liver fibrosis, low or high-risk profile of developing end-stage liver disease was present in nonalcoholic fatty liver disease (NAFLD). However, the mechanisms inducing transition from mild to advanced NAFLD are still elusive. We performed a system-level study on fibrosing-NAFLD by weighted gene co-expression network analysis (WGCNA) to identify significant modules in the network, and followed by functional and pathway enrichment analyses. Moreover, hub genes in the module were analyzed by network feature selection...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28677814/involvement-of-mitochondrial-dynamics-in-the-antineoplastic-activity-of-cisplatin-in-murine-leukemia-l1210-cells
#15
Xiao-Jian Han, Sheng-Lan Shi, Yong-Fang Wei, Li-Ping Jiang, Miao-Yu Guo, Hong-Li Wu, Yu-Ying Wan
Leukemia is a type of hematopoietic stem cell malignant cloned disease with high mortality. Cisplatin-based chemotherapy is one of the most common treatments for leukemia. Similar to other chemotherapeutic agents, cisplatin resistance has become a serious issue in cancer therapy. In the present study, we investigated the role of mitochondrial dynamics in the antineoplastic activity of cisplatin in murine leukemia L1210 cells. Firstly, the L1210 cell line resistant to cisplatin (L1210/DDP) was established. Compared to its parental cell line, the IC50 value of cisplatin in the L1210/DDP cells was increased 10-fold...
August 2017: Oncology Reports
https://www.readbyqxmd.com/read/28673332/a-multicenter-survey-of-first-line-treatment-patterns-and-gene-aberration-test-status-of-patients-with-unresectable-stage-iiib-iv-nonsquamous-non-small-cell-lung-cancer-in-china-ctong-1506
#16
Qing Zhou, Yong Song, Xin Zhang, Gong-Yan Chen, Dian-Sheng Zhong, Zhuang Yu, Ping Yu, Yi-Ping Zhang, Jian-Hua Chen, Yi Hu, Guo-Sheng Feng, Xia Song, Qiang Shi, Lu Lu Yang, Ping Hai Zhang, Yi-Long Wu
BACKGROUND: In recent years, systemic chemotherapy and molecular targeted therapy have become standard first-line treatments for locally advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC). The objective of this survey was to investigate first-line anticancer treatment patterns and gene aberration test status of patients with advanced nonsquamous NSCLC in China. METHODS: Patients included in this study had unresectable Stage IIIB/IV nonsquamous NSCLC and were admitted during August 2015 to March 2016 into one of 12 tertiary hospitals throughout China for first-line anticancer treatment...
July 3, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28670498/application-of-afp-whole-blood-one-step-rapid-detection-kit-in-screening-for-hcc-in-qidong
#17
Jie Jin, Xiao-Yan Zhang, Jin-Lei Shi, Xue-Feng Xue, Ling-Ling Lu, Jian-Hua Lu, Xiao-Ping Jiang, Jiang-Feng Hu, Ben-Song Duan, Chang-Qing Yang, Da-Ru Lu, De-Li Lu, Jian-Guo Chen, Heng-Jun Gao
Hepatocellular carcinoma (HCC) is a big problem in China where the Hepatitis B (HBV) infection patients are near to 120 million. Early screening and diagnosis is the key to reduce the incidence and mortality of HCC. Serum AFP detection is the main methods for diagnosis, recurrent monitoring and therapeutic evaluation of primary HCC. Hepatitis patients should detect the AFP at least once every six months to help early diagnosis of HCC. Unfortunately, most hepatitis and other liver disease patients do not test their AFP regularly...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28657142/comparative-analysis-of-main-bio-active-components-in-the-herb-pair-danshen-honghua-and-its-single-herbs-by-ultra-high-performance-liquid-chromatography-coupled-to-triple-quadrupole-tandem-mass-spectrometry
#18
Cheng Qu, Zong-Jin Pu, Gui-Sheng Zhou, Jun Wang, Zhen-Hua Zhu, Shi-Jun Yue, Jian-Ping Li, Li-Li Shang, Yu-Ping Tang, Xu-Qin Shi, Pei Liu, Jian-Ming Guo, Jing Sun, Zhi-Shu Tang, Jing Zhao, Bu-Chang Zhao, Jin-Ao Duan
A sensitive, reliable and powerful ultra high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry method was developed for simultaneous quantification of the 15 main bio-active components including phenolic acids and flavonoids within 13 min for the first time. The proposed method was first reported and validated by good linearity (r(2)  > 0.9975), limit of detection (1.12-7.01 ng/mL), limit of quantification (3.73-23.37 ng/mL), intra- and inter-day precisions (RSD ≤ 1...
June 28, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28654071/protocols-for-c-brick-dna-standard-assembly-using-cpf1
#19
Shi-Yuan Li, Guo-Ping Zhao, Jin Wang
CRISPR-associated protein Cpf1 cleaves double-stranded DNA under the guidance of CRISPR RNA (crRNA), generating sticky ends. Because of this characteristic, Cpf1 has been used for the establishment of a DNA assembly standard called C-Brick, which has the advantage of long recognition sites and short scars. On a standard C-Brick vector, there are four Cpf1 recognition sites - the prefix (T1 and T2 sites) and the suffix (T3 and T4 sites) - flanking biological DNA parts. The cleavage of T2 and T3 sites produces complementary sticky ends, which allow for the assembly of DNA parts with T2 and T3 sites...
June 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28642235/atomic-layered-au-clusters-on-%C3%AE-moc-as-catalysts-for-the-low-temperature-water-gas-shift-reaction
#20
Siyu Yao, Xiao Zhang, Wu Zhou, Rui Gao, Wenqian Xu, Yifan Ye, Lili Lin, Xiaodong Wen, Ping Liu, Bingbing Chen, Ethan Crumlin, Jinghua Guo, Zhijun Zuo, Weizhen Li, Jinglin Xie, Li Lu, Christopher J Kiely, Lin Gu, Chuan Shi, José A Rodriguez, Ding Ma
The water-gas shift (WGS) reaction (CO+H2O=H2+CO2) is an essential process for hydrogen generation and CO removal in various energy-related chemical operations. This equilibrium-limited reaction is favored at a low working temperature. Potential application in fuel cells also requires a WGS catalyst to be highly active, stable and energy-efficient and match the working temperature of on-site hydrogen generation and consumption units. We synthesized Au layered clusters on an α-MoC substrate to create an interfacial catalyst system for the ultra-low-temperature WGS reaction...
June 22, 2017: Science
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