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https://www.readbyqxmd.com/read/28219888/cd74-deficiency-mitigates-systemic-lupus-erythematosus-like-autoimmunity-and-pathological-findings-in-mice
#1
Yi Zhou, Huimei Chen, Li Liu, Xueqing Yu, Galina K Sukhova, Min Yang, Lijun Zhang, Vasileios C Kyttaris, George C Tsokos, Isaac E Stillman, Takaharu Ichimura, Joseph V Bonventre, Peter Libby, Guo-Ping Shi
CD74 mediates MHC class-II antigenic peptide loading and presentation and plays an important role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus. C57BL/6 Fas(lpr) mice that develop spontaneous lupus-like autoimmunity and pathology showed elevated CD74 expression in the inflammatory cell infiltrates and the adjacent tubular epithelial cells (TECs) in kidneys affected by lupus nephritis but negligible levels in kidneys from age-matched wild-type mice. The inflammatory cytokine IFN-γ or IL-6 induced CD74 expression in kidney TECs in vitro...
February 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28216620/aspirin-alleviates-cardiac-fibrosis-in-mice-by-inhibiting-autophagy
#2
Ping-Ping Liu, Hong-Hong Liu, Shu-Hong Sun, Xing-Xing Shi, Wan-Cheng Yang, Guo-Hai Su, Jing Zhao
Aspirin (ASA) is a cardioprotective drug with anti-cardiac fibrosis action in vivo. This study was aimed to clarify the anti-cardiac fibrosis action of ASA and the underlying mechanisms. Two heart injury models (injection of isoproterenol and ligation of the left anterior descending branch) were used in mice to induce cardiac fibrosis. The animals were treated with ASA (10 mg·kg(-1)·d(-1), ig) for 21 and 14 d, respectively. ASA administration significantly improved cardiac function, and ameliorated heart damage and fibrosis in the mice...
February 20, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28164340/relationships-between-soil-fungal-and-woody-plant-assemblages-differ-between-ridge-and-valley-habitats-in-a-subtropical-mountain-forest
#3
Cheng Gao, Nan-Nan Shi, Liang Chen, Niu-Niu Ji, Bin-Wei Wu, Yong-Long Wang, Ying Xu, Yong Zheng, Xiang-Cheng Mi, Ke-Ping Ma, Liang-Dong Guo
Elucidating interactions of above-ground and below-ground communities in different habitat types is essential for understanding biodiversity maintenance and ecosystem functioning. Using 454 pyrosequencing of ITS2 sequences we examined the relationship between subtropical mountain forest soil fungal communities, abiotic conditions, and plant communities using correlation and partial models. Ridge and valley habitats with differing fungal communities were delineated. Total, saprotrophic and pathogenic fungal richness were significantly correlated with plant species richness and/or soil nutrients and moisture in the ridge habitat, but with habitat convexity or basal area of Castanopsis eyrei in the valley habitat...
March 2017: New Phytologist
https://www.readbyqxmd.com/read/28154948/reduced-production-of-diacetyl-by-overexpressing-bdh2-gene-and-ilv5-gene-in-yeast-of-the-lager-brewers-with-one-ilv2-allelic-gene-deleted
#4
Ting-Ting Shi, Ping Li, Shi-Jia Chen, Ye-Fu Chen, Xue-Wu Guo, Dong-Guang Xiao
Diacetyl causes an unwanted buttery off-flavor in lager beer. The production of diacetyl is reduced by modifying the metabolic pathway of yeast in the beer fermentation process. In this study, BDH2 and ILV5 genes, coding diacetyl reductase and acetohydroxy acid reductoisomerase, respectively, were expressed using a PGK1 promoter in Saccharomyces cerevisiae, which deleted one ILV2 allelic gene. Diacetyl contents and fermentation performances were examined and compared. Results showed that the diacetyl content in beer was remarkably reduced by 16...
February 2, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28134505/china-experts-consensus-on-the-diagnosis-and-treatment-of-advanced-stage-primary-lung-cancer-2016-version
#5
Yuankai Shi, Yan Sun, Jinming Yu, Cuimin Ding, Ziping Wang, Changli Wang, Dong Wang, Cunde Wang, Zheng Wang, Mengzhao Wang, Xiuyi Zhi, You Lu, Jifeng Feng, Yunpeng Liu, Xiaoqing Liu, Wei Liu, Gang Wu, Xiaomei Li, Kai Li, Enxiao Li, Wei Li, Gongyan Chen, Zhengtang Chen, Ping Yu, Ning Wu, Milu Wu, Wenhua Xiao, Li Zhang, Yiping Zhang, Shucai Zhang, Shujun Yang, Xia Song, Dongmei Lin, Rongcheng Luo, Li Shan, Caicun Zhou, Zongmei Zhou, Qiong Zhao, Chengping Hu, Yi Hu, Qisen Guo, Jianhua Chang, Cheng Huang, Xuan Zeng, Baohui Han, Xiaohong Han, Bo Jia, Ying Han, Yu Huang
No abstract text is available yet for this article.
February 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28134320/rna-binding-protein-rbm3-prevents-no-induced-apoptosis-in-human-neuroblastoma-cells-by-modulating-p38-signaling-and-mir-143
#6
Hai-Jie Yang, Fei Ju, Xin-Xin Guo, Shuang-Ping Ma, Lei Wang, Bin-Feng Cheng, Rui-Juan Zhuang, Bin-Bin Zhang, Xiang Shi, Zhi-Wei Feng, Mian Wang
Nitric oxide (NO)-induced apoptosis in neurons is an important cause of neurodegenerative disease in humans. The cold-inducible protein RBM3 mediates the protective effects of cooling on apoptosis induced by various insults. However, whether RBM3 protects neural cells from NO-induced apoptosis is unclear. This study aimed to investigate the neuroprotective effect of RBM3 on NO-induced apoptosis in human SH-SY5Y neuroblastoma cells. Firstly, we demonstrated that mild hypothermia (32 °C) induces RBM3 expression and confers a potent neuroprotective effect on NO-induced apoptosis, which was substantially diminished when RBM3 was silenced by siRNA...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28120487/adjunctive-antidepressant-use-in-schizophrenia-in-china-a-national-survey-2002-2012
#7
Qian Li, Yun-Ai Su, Yu-Tao Xiang, Liang Shu, Xin Yu, Gabor S Ungvari, Chee H Ng, Helen F K Chiu, Yu-Ping Ning, Gao-Hua Wang, Ke-Rang Zhang, Tao Li, Li-Zhong Sun, Jian-Guo Shi, Xian-Sheng Chen, Qi-Yi Mei, Ke-Qing Li, Tian-Mei Si
OBJECTIVE: This study examined the pattern of adjunctive antidepressant use in schizophrenia patients and its demographic and clinical correlates in a nationwide survey in China. METHODS: Fourteen thousand and thirteen patients in 45 Chinese psychiatric hospitals or centers were interviewed (4,486 in 2002, 5,288 in 2006, and 4,239 in 2012). Patients' sociodemographic and clinical characteristics were recorded using a standardized protocol and data collection procedure...
January 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28115632/the-cctl-cpf1-assisted-cutting-and-taq-dna-ligase-assisted-ligation-method-for-efficient-editing-of-large-dna-constructs-in-vitro
#8
Chao Lei, Shi-Yuan Li, Jia-Kun Liu, Xuan Zheng, Guo-Ping Zhao, Jin Wang
As Cpf1 cleaves double-stranded DNA in a staggered way, it can be used in DNA assembly. However, the Cpf1 cleavage was found to be inaccurate, which may cause errors in DNA assembly. Here, the Cpf1 cleavage sites were precisely characterized, where the cleavage site on the target strand was around the 22nd base relative to the protospacer adjacent motif site, but the cleavage on the non-target strand was affected by the spacer length. When the spacer length was 20 nt or longer, Cpf1 mainly cleaved around the 14th and the 18th bases on the non-target strand; otherwise, with a shorter spacer (i...
January 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28106414/amplitude-analysis-of-the-decays-%C3%AE-%C3%A2-%C3%AF-%C3%AF-%C3%AF-0-and-%C3%AE-%C3%A2-%C3%AF-0-%C3%AF-0-%C3%AF-0
#9
M Ablikim, M N Achasov, X C Ai, O Albayrak, M Albrecht, D J Ambrose, A Amoroso, F F An, Q An, J Z Bai, R Baldini Ferroli, Y Ban, D W Bennett, J V Bennett, M Bertani, D Bettoni, J M Bian, F Bianchi, E Boger, I Boyko, R A Briere, H Cai, X Cai, O Cakir, A Calcaterra, G F Cao, S A Cetin, J F Chang, G Chelkov, G Chen, H S Chen, H Y Chen, J C Chen, M L Chen, S Chen, S J Chen, X Chen, X R Chen, Y B Chen, H P Cheng, X K Chu, G Cibinetto, H L Dai, J P Dai, A Dbeyssi, D Dedovich, Z Y Deng, A Denig, I Denysenko, M Destefanis, F De Mori, Y Ding, C Dong, J Dong, L Y Dong, M Y Dong, Z L Dou, S X Du, P F Duan, J Z Fan, J Fang, S S Fang, X Fang, Y Fang, R Farinelli, L Fava, O Fedorov, F Feldbauer, G Felici, C Q Feng, E Fioravanti, M Fritsch, C D Fu, Q Gao, X L Gao, X Y Gao, Y Gao, Z Gao, I Garzia, K Goetzen, L Gong, W X Gong, W Gradl, M Greco, M H Gu, Y T Gu, Y H Guan, A Q Guo, L B Guo, R P Guo, Y Guo, Y P Guo, Z Haddadi, A Hafner, S Han, X Q Hao, F A Harris, K L He, T Held, Y K Heng, Z L Hou, C Hu, H M Hu, J F Hu, T Hu, Y Hu, G S Huang, J S Huang, X T Huang, X Z Huang, Y Huang, Z L Huang, T Hussain, Q Ji, Q P Ji, X B Ji, X L Ji, L W Jiang, X S Jiang, X Y Jiang, J B Jiao, Z Jiao, D P Jin, S Jin, T Johansson, A Julin, N Kalantar-Nayestanaki, X L Kang, X S Kang, M Kavatsyuk, B C Ke, P Kiese, R Kliemt, B Kloss, O B Kolcu, B Kopf, M Kornicer, A Kupsc, W Kühn, J S Lange, M Lara, P Larin, C Leng, C Li, Cheng Li, D M Li, F Li, F Y Li, G Li, H B Li, H J Li, J C Li, Jin Li, K Li, K Li, Lei Li, P R Li, Q Y Li, T Li, W D Li, W G Li, X L Li, X N Li, X Q Li, Y B Li, Z B Li, H Liang, Y F Liang, Y T Liang, G R Liao, D X Lin, B Liu, B J Liu, C X Liu, D Liu, F H Liu, Fang Liu, Feng Liu, H B Liu, H H Liu, H H Liu, H M Liu, J Liu, J B Liu, J P Liu, J Y Liu, K Liu, K Y Liu, L D Liu, P L Liu, Q Liu, S B Liu, X Liu, Y B Liu, Z A Liu, Zhiqing Liu, H Loehner, X C Lou, H J Lu, J G Lu, Y Lu, Y P Lu, C L Luo, M X Luo, T Luo, X L Luo, X R Lyu, F C Ma, H L Ma, L L Ma, M M Ma, Q M Ma, T Ma, X N Ma, X Y Ma, Y M Ma, F E Maas, M Maggiora, Y J Mao, Z P Mao, S Marcello, J G Messchendorp, J Min, T J Min, R E Mitchell, X H Mo, Y J Mo, C Morales Morales, N Yu Muchnoi, H Muramatsu, Y Nefedov, F Nerling, I B Nikolaev, Z Ning, S Nisar, S L Niu, X Y Niu, S L Olsen, Q Ouyang, S Pacetti, Y Pan, P Patteri, M Pelizaeus, H P Peng, K Peters, J Pettersson, J L Ping, R G Ping, R Poling, V Prasad, H R Qi, M Qi, S Qian, C F Qiao, L Q Qin, N Qin, X S Qin, Z H Qin, J F Qiu, K H Rashid, C F Redmer, M Ripka, G Rong, Ch Rosner, X D Ruan, A Sarantsev, M Savrié, K Schoenning, S Schumann, W Shan, M Shao, C P Shen, P X Shen, X Y Shen, H Y Sheng, M Shi, W M Song, X Y Song, S Sosio, S Spataro, G X Sun, J F Sun, S S Sun, X H Sun, Y J Sun, Y Z Sun, Z J Sun, Z T Sun, C J Tang, X Tang, I Tapan, E H Thorndike, M Tiemens, M Ullrich, I Uman, G S Varner, B Wang, B L Wang, D Wang, D Y Wang, K Wang, L L Wang, L S Wang, M Wang, P Wang, P L Wang, W Wang, W P Wang, X F Wang, Y Wang, Y D Wang, Y F Wang, Y Q Wang, Z Wang, Z G Wang, Z H Wang, Z Y Wang, Z Y Wang, T Weber, D H Wei, P Weidenkaff, S P Wen, U Wiedner, M Wolke, L H Wu, L J Wu, Z Wu, L Xia, L G Xia, Y Xia, D Xiao, H Xiao, Z J Xiao, Y G Xie, Q L Xiu, G F Xu, J J Xu, L Xu, Q J Xu, Q N Xu, X P Xu, L Yan, W B Yan, W C Yan, Y H Yan, H J Yang, H X Yang, L Yang, Y X Yang, M Ye, M H Ye, J H Yin, B X Yu, C X Yu, J S Yu, C Z Yuan, W L Yuan, Y Yuan, A Yuncu, A A Zafar, A Zallo, Y Zeng, Z Zeng, B X Zhang, B Y Zhang, C Zhang, C C Zhang, D H Zhang, H H Zhang, H Y Zhang, J Zhang, J J Zhang, J L Zhang, J Q Zhang, J W Zhang, J Y Zhang, J Z Zhang, K Zhang, L Zhang, S Q Zhang, X Y Zhang, Y Zhang, Y H Zhang, Y N Zhang, Y T Zhang, Yu Zhang, Z H Zhang, Z P Zhang, Z Y Zhang, G Zhao, J W Zhao, J Y Zhao, J Z Zhao, Lei Zhao, Ling Zhao, M G Zhao, Q Zhao, Q W Zhao, S J Zhao, T C Zhao, Y B Zhao, Z G Zhao, A Zhemchugov, B Zheng, J P Zheng, W J Zheng, Y H Zheng, B Zhong, L Zhou, X Zhou, X K Zhou, X R Zhou, X Y Zhou, K Zhu, K J Zhu, S Zhu, S H Zhu, X L Zhu, Y C Zhu, Y S Zhu, Z A Zhu, J Zhuang, L Zotti, B S Zou, J H Zou
Based on a sample of 1.31×10^{9}  J/ψ events collected with the BESIII detector, an amplitude analysis of the isospin-violating decays η^{'}→π^{+}π^{-}π^{0} and η^{'}→π^{0}π^{0}π^{0} is performed. A significant P-wave contribution from η^{'}→ρ^{±}π^{∓} is observed for the first time in η^{'}→π^{+}π^{-}π^{0}. The branching fraction is determined to be B(η^{'}→ρ^{±}π^{∓})=(7.44±0.60±1.26±1.84)×10^{-4}, where the first uncertainty is statistical, the second systematic, and the third model dependent...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28105082/genetic-diagnosis-and-treatment-of-a-chinese-ketosis-prone-mody-3-family-with-depression
#10
Jun Tang, Chen-Yi Tang, Fang Wang, Yue Guo, Hao-Neng Tang, Ci-La Zhou, Shu-Wen Tan, Shi-Ping Liu, Zhi-Guang Zhou, Hou-De Zhou
BACKGROUND: To analyze the gene mutation and mental disorder of a Chinese ketosis-prone diabetes (KPD) family, and to make a precise diagnosis and give a treatment for them. METHODS: We studied a Chinese family with a clinical diagnosis of maturity-onset diabetes of the young (MODY). The clinical data and the blood samples were collected. The promotor and coding regions inclusive intron exon boundaries of the HNF1A, HNF4A were detected by polymerase chain reaction (PCR) and direct sequencing...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28103967/-china-experts-consensus-on-the-diagnosis-and-treatment-of-brain-metastases-of-lung-cancer-2017-version
#11
Yuankai Shi, Yan Sun, Jinming Yu, Cuimin Ding, Zhiyong Ma, Ziping Wang, Dong Wang, Zheng Wang, Mengzhao Wang, Yan Wang, You Lu, Bin Ai, Jifeng Feng, Yunpeng Liu, Xiaoqing Liu, Jiwei Liu, Gang Wu, Baolin Qu, Xueji Li, Enxiao Li, Wei Li, Yong Song, Gongyan Chen, Zhengtang Chen, Jun Chen, Ping Yu, Ning Wu, Milu Wu, Wenhua Xiao, Jianping Xiao, Li Zhang, Yang Zhang, Yiping Zhang, Shucai Zhang, Xia Song, Rongcheng Luo, Caicun Zhou, Zongmei Zhou, Qiong Zhao, Chengping Hu, Yi Hu, Ligong Nie, Qisen Guo, Jianhua Chang, Cheng Huang, Baohui Han, Xiaohong Han, Gong Li, Yu Huang, Youwu Shi
No abstract text is available yet for this article.
January 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28103911/comparison-of-the-effectiveness-and-safety-of-topical-versus-intravenous-tranexamic-acid-in-primary-total-knee-arthroplasty-a-meta-analysis-of-randomized-controlled-trials
#12
Tao-Ping Chen, Yu-Min Chen, Jian-Bao Jiao, Yun-Fei Wang, Li-Gang Qian, Zhao Guo, Zheng Ma, Cui-Yu Han, Tong-Huan Shi
BACKGROUND: This study aims to compare the effectiveness and safety of topical versus intravenous tranexamic acid (TXA) in reducing blood loss in primary total knee arthroplasty (TKA). METHODS: PubMed, Embase, the Cochrane Library, Web of Science, Chinese Biomedicine Literature (CBM), Wanfang Database and China National Knowledge Infrastructure (CNKI), and Google Scholar were searched for randomized controlled studies (RCTs) that compared topical versus intravenous TXA in terms of reducing blood loss during TKA from their inception to September 2015...
January 19, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28093526/cathepsin-k-deficiency-ameliorates-systemic-lupus-erythematosus-like-manifestations-in-faslpr-mice
#13
Yi Zhou, Huimei Chen, Li Liu, Xueqing Yu, Galina K Sukhova, Min Yang, Vasileios C Kyttaris, Isaac E Stillman, Bruce Gelb, Peter Libby, George C Tsokos, Guo-Ping Shi
Cysteinyl cathepsin K (CatK) is expressed in osteoclasts to mediate bone resorption, but is also inducible under inflammatory conditions. Fas(lpr) mice on a C57BL/6 background develop spontaneous systemic lupus erythematosus-like manifestations. Although normal mouse kidneys expressed negligible CatK, those from Fas(lpr) mice showed elevated CatK expression in the glomeruli and tubulointerstitial space. Fas(lpr) mice also showed elevated serum CatK levels. CatK deficiency in Fas(lpr) mice reduced all tested kidney pathologies, including glomerulus and tubulointerstitial scores, glomerulus complement C3 and IgG deposition, chemokine expression and macrophage infiltration, and serum autoantibodies...
January 16, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28088671/melatonin-attenuates-titanium-particle-induced-osteolysis-via-activation-of-wnt-%C3%AE-catenin-signaling-pathway
#14
Zichuan Ping, Xuanyang Hu, Liangliang Wang, Jiawei Shi, Yunxia Tao, Xiexing Wu, Zhenyang Hou, Xiaobin Guo, Wen Zhang, Huilin Yang, Yaozeng Xu, Zhirong Wang, Dechun Geng
: Wear debris-induced inhibition of bone regeneration and extensive bone resorption were common features in peri-prosthetic osteolysis (PPO). Here, we investigated the effect of melatonin on titanium particle-stimulated osteolysis in a murine calvariae model and mouse-mesenchymal-stem cells (mMSCs) culture system. Melatonin inhibited titanium particle-induced osteolysis and increased bone formation at osteolytic sites, confirmed by radiological and histomorphometric data. Furthermore, osteoclast numbers decreased dramatically in the low- and high-melatonin administration mice, as respectively, compared with the untreated animals...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28054578/reply-the-complexity-of-substance-p-mediated-mast-cell-activation
#15
Guo-Ping Shi, Ilze Bot, Petri T Kovanen
No abstract text is available yet for this article.
January 5, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28033540/cathepsin-s-inhibition-changes-regulatory-t-cell-activity-in-regulating-bladder-cancer-and-immune-cell-proliferation-and-apoptosis
#16
Xiang Yan, Chun Wu, Tao Chen, Marcela M Santos, Cong-Lin Liu, Chongzhe Yang, Lijun Zhang, Jingyuan Ren, Sha Liao, Hongqiang Guo, Galina K Sukhova, Guo-Ping Shi
Regulatory T cells (Tregs) are immune suppressive cells, but their roles in tumor growth have been elusive, depending on tumor type or site. Our prior study demonstrated a role of cathepsin S (CatS) in reducing Treg immunosuppressive activity. Therefore, CatS inhibition in Tregs may exacerbate tumor growth. Using mouse bladder carcinoma MB49 cell subcutaneous implant tumor model, we detected no difference in tumor growth, whether mice were given saline- or CatS inhibitor-treated Tregs. However, mice that received inhibitor-treated Tregs had fewer splenic and tumor Tregs, and lower levels of tumor and splenic cell proliferation than mice that received saline-treated Tregs...
December 26, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/28027085/bispectral-index-can-reliably-detect-deep-sedation-in-mechanically-ventilated-patients-a-prospective-multicenter-validation-study
#17
Zhu-Heng Wang, Han Chen, Yan-Lin Yang, Zhong-Hua Shi, Qing-Hua Guo, Yu-Wei Li, Li-Ping Sun, Wei Qiao, Guan-Hua Zhou, Rong-Guo Yu, Kai Yin, Xuan He, Ming Xu, Laurent J Brochard, Jian-Xin Zhou
BACKGROUND: Excessively deep sedation is prevalent in mechanically ventilated patients and often considered suboptimal. We hypothesized that the bispectral index (BIS), a quantified electroencephalogram instrument, would accurately detect deep levels of sedation. METHODS: We prospectively enrolled 90 critically ill mechanically ventilated patients who were receiving sedation. The BIS was monitored for 24 hours and compared with the Richmond Agitation Sedation Scale (RASS) evaluated every 4 hours...
December 22, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28025329/association-between-gwas-identified-lung-adenocarcinoma-susceptibility-loci-and-egfr-mutations-in-never-smoking-asian-women-and-comparison-with-findings-from-western-populations
#18
Wei Jie Seow, Keitaro Matsuo, Chao Agnes Hsiung, Kouya Shiraishi, Minsun Song, Hee Nam Kim, Maria Pik Wong, Yun-Chul Hong, H Dean Hosgood, Zhaoming Wang, I-Shou Chang, Jiu-Cun Wang, Nilanjan Chatterjee, Margaret Tucker, Hu Wei, Tetsuya Mitsudomi, Wei Zheng, Jin Hee Kim, Baosen Zhou, Neil E Caporaso, Demetrius Albanes, Min-Ho Shin, Lap Ping Chung, She-Juan An, Ping Wang, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young Tae Kim, Xiao-Ou Shu, Young-Chul Kim, Bryan A Bassig, Jiang Chang, James Chung Man Ho, Bu-Tian Ji, Michiaki Kubo, Yataro Daigo, Hidemi Ito, Yukihide Momozawa, Kyota Ashikawa, Yoichiro Kamatani, Takayuki Honda, Hiromi Sakamoto, Hideo Kunitoh, Koji Tsuta, Shun-Ichi Watanabe, Hiroshi Nokihara, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Masahiro Tsuboi, Koichi Goto, Zhihua Yin, Jianxin Shi, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Kimihiro Shimizu, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Jason Y Y Wong, Fumihiko Matsuda, Jian Su, Yeul Hong Kim, In-Jae Oh, Fengju Song, Victor Ho Fun Lee, Wu-Chou Su, Yuh-Min Chen, Gee-Chen Chang, Kuan-Yu Chen, Ming-Shyan Huang, Pan-Chyr Yang, Hsien-Chih Lin, Yong-Bing Xiang, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Chien-Jen Chen, Haixin Li, Yu-Tang Gao, Chen Wu, Biyun Qian, Daru Lu, Jianjun Liu, Hyo-Sung Jeon, Chin-Fu Hsiao, Jae Sook Sung, Ying-Huang Tsai, Yoo Jin Jung, Huan Guo, Zhibin Hu, Wen-Chang Wang, Charles C Chung, Charles Lawrence, Laurie Burdett, Meredith Yeager, Kevin B Jacobs, Amy Hutchinson, Sonja I Berndt, Xingzhou He, Wei Wu, Junwen Wang, Yuqing Li, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Lingmin Hu, Chung-Hsing Chen, Tsung-Ying Yang, Jun Xu, Peng Guan, Wen Tan, Chih-Liang Wang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jen-Yu Hung, Jun Suk Kim, Ho-Il Yoon, Qiuyin Cai, Chien-Chung Lin, In Kyu Park, Ping Xu, Jing Dong, Christopher Kim, Qincheng He, Reury-Perng Perng, Chih-Yi Chen, Roel Vermeulen, Junjie Wu, Wei-Yen Lim, Kun-Chieh Chen, John K C Chan, Minjie Chu, Yao-Jen Li, Jihua Li, Hongyan Chen, Chong-Jen Yu, Li Jin, Yen-Li Lo, Ying-Hsiang Chen, Joseph F Fraumeni, Jie Liu, Taiki Yamaji, Yang Yang, Belynda Hicks, Kathleen Wyatt, Shengchao A Li, Juncheng Dai, Hongxia Ma, Guangfu Jin, Bao Song, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Ping Cui, Motoki Iwasaki, Taichi Shimazu, Shoichiro Tsugane, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Li-Hsin Chien, Hui-Ling Chen, Yu-Chun Su, Fang-Yu Tsai, Yi-Song Chen, Jinming Yu, Victoria L Stevens, Ite A Laird-Offringa, Crystal N Marconett, Dongxin Lin, Kexin Chen, Yi-Long Wu, Maria Teresa Landi, Hongbing Shen, Nathaniel Rothman, Takashi Kohno, Stephen J Chanock, Qing Lan
To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10(-8)), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21...
December 26, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27994455/reduced-staphylococcus-aureus-biofilm-formation-in-the-presence-of-chitosan-coated-iron-oxide-nanoparticles
#19
Si-Feng Shi, Jing-Fu Jia, Xiao-Kui Guo, Ya-Ping Zhao, De-Sheng Chen, Yong-Yuan Guo, Xian-Long Zhang
Staphylococcus aureus can adhere to most foreign materials and form biofilm on the surface of medical devices. Biofilm infections are difficult to resolve. The goal of this in vitro study was to explore the use of chitosan-coated nanoparticles to prevent biofilm formation. For this purpose, S. aureus was seeded in 96-well plates to incubate with chitosan-coated iron oxide nanoparticles in order to study the efficiency of biofilm formation inhibition. The biofilm bacteria count was determined using the spread plate method; biomass formation was measured using the crystal violet staining method...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27982610/measurement-of-singly-cabibbo-suppressed-decays-%C3%AE-_-c-%C3%A2-p%C3%AF-%C3%AF-and-%C3%AE-_-c-%C3%A2-pk-k
#20
M Ablikim, M N Achasov, S Ahmed, X C Ai, O Albayrak, M Albrecht, D J Ambrose, A Amoroso, F F An, Q An, J Z Bai, O Bakina, R Baldini Ferroli, Y Ban, D W Bennett, J V Bennett, N Berger, M Bertani, D Bettoni, J M Bian, F Bianchi, E Boger, I Boyko, R A Briere, H Cai, X Cai, O Cakir, A Calcaterra, G F Cao, S A Cetin, J Chai, J F Chang, G Chelkov, G Chen, H S Chen, J C Chen, M L Chen, S Chen, S J Chen, X Chen, X R Chen, Y B Chen, H P Cheng, X K Chu, G Cibinetto, H L Dai, J P Dai, A Dbeyssi, D Dedovich, Z Y Deng, A Denig, I Denysenko, M Destefanis, F De Mori, Y Ding, C Dong, J Dong, L Y Dong, M Y Dong, Z L Dou, S X Du, P F Duan, J Z Fan, J Fang, S S Fang, X Fang, Y Fang, R Farinelli, L Fava, S Fegan, F Feldbauer, G Felici, C Q Feng, E Fioravanti, M Fritsch, C D Fu, Q Gao, X L Gao, Y Gao, Z Gao, I Garzia, K Goetzen, L Gong, W X Gong, W Gradl, M Greco, M H Gu, Y T Gu, Y H Guan, A Q Guo, L B Guo, R P Guo, Y Guo, Y P Guo, Z Haddadi, A Hafner, S Han, X Q Hao, F A Harris, K L He, F H Heinsius, T Held, Y K Heng, T Holtmann, Z L Hou, C Hu, H M Hu, J F Hu, T Hu, Y Hu, G S Huang, J S Huang, X T Huang, X Z Huang, Y Huang, Z L Huang, T Hussain, W Ikegami Andersson, Q Ji, Q P Ji, X B Ji, X L Ji, L W Jiang, X S Jiang, X Y Jiang, J B Jiao, Z Jiao, D P Jin, S Jin, T Johansson, A Julin, N Kalantar-Nayestanaki, X L Kang, X S Kang, M Kavatsyuk, B C Ke, P Kiese, R Kliemt, B Kloss, O B Kolcu, B Kopf, M Kornicer, A Kupsc, W Kühn, J S Lange, M Lara, P Larin, H Leithoff, C Leng, C Li, Cheng Li, D M Li, F Li, F Y Li, G Li, H B Li, H J Li, J C Li, Jin Li, K Li, K Li, Lei Li, P L Li, P R Li, Q Y Li, T Li, W D Li, W G Li, X L Li, X N Li, X Q Li, Y B Li, Z B Li, H Liang, Y F Liang, Y T Liang, G R Liao, D X Lin, B Liu, B J Liu, C X Liu, D Liu, F H Liu, Fang Liu, Feng Liu, H B Liu, H H Liu, H H Liu, H M Liu, J Liu, J B Liu, J P Liu, J Y Liu, K Liu, K Y Liu, L D Liu, P L Liu, Q Liu, S B Liu, X Liu, Y B Liu, Y Y Liu, Z A Liu, Zhiqing Liu, H Loehner, Y F Long, X C Lou, H J Lu, J G Lu, Y Lu, Y P Lu, C L Luo, M X Luo, T Luo, X L Luo, X R Lyu, F C Ma, H L Ma, L L Ma, M M Ma, Q M Ma, T Ma, X N Ma, X Y Ma, Y M Ma, F E Maas, M Maggiora, Q A Malik, Y J Mao, Z P Mao, S Marcello, J G Messchendorp, G Mezzadri, J Min, T J Min, R E Mitchell, X H Mo, Y J Mo, C Morales Morales, N Yu Muchnoi, H Muramatsu, P Musiol, Y Nefedov, F Nerling, I B Nikolaev, Z Ning, S Nisar, S L Niu, X Y Niu, S L Olsen, Q Ouyang, S Pacetti, Y Pan, P Patteri, M Pelizaeus, H P Peng, K Peters, J Pettersson, J L Ping, R G Ping, R Poling, V Prasad, H R Qi, M Qi, S Qian, C F Qiao, L Q Qin, N Qin, X S Qin, Z H Qin, J F Qiu, K H Rashid, C F Redmer, M Ripka, G Rong, Ch Rosner, X D Ruan, A Sarantsev, M Savrié, C Schnier, K Schoenning, S Schumann, W Shan, M Shao, C P Shen, P X Shen, X Y Shen, H Y Sheng, M Shi, W M Song, X Y Song, S Sosio, S Spataro, G X Sun, J F Sun, S S Sun, X H Sun, Y J Sun, Y Z Sun, Z J Sun, Z T Sun, C J Tang, X Tang, I Tapan, E H Thorndike, M Tiemens, I Uman, G S Varner, B Wang, B L Wang, D Wang, D Y Wang, K Wang, L L Wang, L S Wang, M Wang, P Wang, P L Wang, W Wang, W P Wang, X F Wang, Y Wang, Y D Wang, Y F Wang, Y Q Wang, Z Wang, Z G Wang, Z H Wang, Z Y Wang, Z Y Wang, T Weber, D H Wei, P Weidenkaff, S P Wen, U Wiedner, M Wolke, L H Wu, L J Wu, Z Wu, L Xia, L G Xia, Y Xia, D Xiao, H Xiao, Z J Xiao, Y G Xie, Q L Xiu, G F Xu, J J Xu, L Xu, Q J Xu, Q N Xu, X P Xu, L Yan, W B Yan, W C Yan, Y H Yan, H J Yang, H X Yang, L Yang, Y X Yang, M Ye, M H Ye, J H Yin, Z Y You, B X Yu, C X Yu, J S Yu, C Z Yuan, W L Yuan, Y Yuan, A Yuncu, A A Zafar, A Zallo, Y Zeng, Z Zeng, B X Zhang, B Y Zhang, C Zhang, C C Zhang, D H Zhang, H H Zhang, H Y Zhang, J Zhang, J J Zhang, J L Zhang, J Q Zhang, J W Zhang, J Y Zhang, J Z Zhang, K Zhang, L Zhang, S Q Zhang, X Y Zhang, Y Zhang, Y Zhang, Y H Zhang, Y N Zhang, Y T Zhang, Yu Zhang, Z H Zhang, Z P Zhang, Z Y Zhang, G Zhao, J W Zhao, J Y Zhao, J Z Zhao, Lei Zhao, Ling Zhao, M G Zhao, Q Zhao, Q W Zhao, S J Zhao, T C Zhao, Y B Zhao, Z G Zhao, A Zhemchugov, B Zheng, J P Zheng, W J Zheng, Y H Zheng, B Zhong, L Zhou, X Zhou, X K Zhou, X R Zhou, X Y Zhou, K Zhu, K J Zhu, S Zhu, S H Zhu, X L Zhu, Y C Zhu, Y S Zhu, Z A Zhu, J Zhuang, L Zotti, B S Zou, J H Zou
Using 567  pb^{-1} of data collected with the BESIII detector at a center-of-mass energy of sqrt[s]=4.599  GeV, near the Λ_{c}^{+}Λ[over ¯]_{c}^{-} threshold, we study the singly Cabibbo-suppressed decays Λ_{c}^{+}→pπ^{+}π^{-} and Λ_{c}^{+}→pK^{+}K^{-}. By normalizing with respect to the Cabibbo-favored decay Λ_{c}^{+}→pK^{-}π^{+}, we obtain ratios of branching fractions: [B(Λ_{c}^{+}→pπ^{+}π^{-})/B(Λ_{c}^{+}→pK^{-}π^{+})]=(6.70±0.48±0.25)%, [B(Λ_{c}^{+}→pϕ)/B(Λ_{c}^{+}→pK^{-}π^{+})]=(1...
December 2, 2016: Physical Review Letters
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