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Guo ping shi

Siliang Xu, Ping Duan, Jinping Li, Tristan Senkowski, Fengbiao Guo, Haibin Chen, Alberto Romero, Yugui Cui, Jiayin Liu, Shi-Wen Jiang
SET (SE Translocation) protein carries out multiple functions including those for protein phosphatase 2A (PP2A) inhibition, histone modification, DNA repair, and gene regulation. SET overexpression has been detected in brain neurons of patients suffering Alzheimer's disease, follicle theca cells of Polycystic Ovary Syndrome (PCOS) patients, and ovarian cancer cells, indicating that SET may play a pathological role for these disorders. SET transcript 2, produced by a specific promoter, represents a major transcript variant in different cell types...
October 20, 2016: International Journal of Molecular Sciences
Fen Li, Shi-Ping Wang, Chang-Jian Wang, Shi-Cheng He, Xiang Wu, Guo-Hua Liu
Toxoplasma gondii infections are prevalent in animals and humans worldwide. In the present investigation, the seroprevalence of T. gondii in goats was investigated in Hunan province, subtropical China between March 2014 and December 2015. A total of 1,028 serum samples collected from 14 administrative regions of Hunan province were evaluated by the indirect hemagglutination test (IHAT) for the detection of specific antibodies. Antibodies to T. gondii were detected in 124 serum samples (12%). The T. gondii seroprevalence ranged from 1...
2016: Parasite: Journal de la Société Française de Parasitologie
Qian Li, Yun-Ai Su, Yu-Tao Xiang, Liang Shu, Xin Yu, Gabor S Ungvari, Stephen J Seiner, Helen F K Chiu, Yu-Ping Ning, Gao-Hua Wang, Ke-Rang Zhang, Tao Li, Li-Zhong Sun, Jian-Guo Shi, Xian-Sheng Chen, Qi-Yi Mei, Ke-Qing Li, Tian-Mei Si
OBJECTIVE: Little is known about electroconvulsive therapy (ECT) use in the treatment of schizophrenia in China. This study examined the frequency of ECT use, its trend between 2006 and 2012, and its independent demographic and clinical correlates in a nationwide survey in China. METHODS: A total of 5162 inpatients in 45 Chinese psychiatric hospitals/centers were interviewed (2696 in 2006 and 2466 in 2012). Patients' sociodemographic and clinical characteristics were recorded using a standardized protocol and data collection procedure...
October 7, 2016: Journal of ECT
Yi Yang, Juan Wen, Liqiang Guo, Xiang Wan, Peifu Du, Ping Feng, Yi Shi, Qing Wan
Emulating neural behaviors at the synaptic level is of great significance for building neuromorphic computational systems and realizing artificial intelligence. Here, oxide-based electric-double-layer (EDL) thin-film transistors were fabricated by using 3-triethoxysilylpropylamine modified graphene oxide (KH550-GO) electrolyte as the gate dielectrics. Resulting from the EDL effect and electrochemical doping between mobile protons and the indium-zinc-oxide channel layer, long-term synaptic plasticity was emulated in our devices...
October 17, 2016: ACS Applied Materials & Interfaces
Ming-Jie Wang, Yong-Jun Luo, Zhi-Yong Shi, Xiao-Liang Xu, Guo-Liang Yao, Rui-Ping Liu, Hui Zhao
Considerable studies have investigated the associations between MDM4 gene polymorphisms and cancer risk recently, but with contradictory results. The aim of this meta-analysis was to evaluate the associations between MDM4 gene polymorphisms and cancer risk. Relevant studies were identified by a systematic search of PubMed, Embase, and CNKI databases. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were used to describe the strength of the associations. Fifty-six studies published in 11 publications involving 18,910 cases and 51,609 controls were included in this meta-analysis...
July 28, 2016: Oncotarget
Xianhui Qin, Jianping Li, J David Spence, Yan Zhang, Youbao Li, Xiaobin Wang, Binyan Wang, Ningling Sun, Fang Chen, Jingxuan Guo, Delu Yin, Liming Sun, Genfu Tang, Mingli He, Jia Fu, Yefeng Cai, Xiuli Shi, Ping Ye, Hong Chen, Shuiping Zhao, Mao Chen, Chuanyu Gao, Xiangqing Kong, Fan Fan Hou, Yining Huang, Yong Huo
BACKGROUND AND PURPOSE: We sought to determine whether folic acid supplementation can independently reduce the risk of first stroke associated with elevated total cholesterol levels in a subanalysis using data from the CSPPT (China Stroke Primary Prevention Trial), a double-blind, randomized controlled trial. METHODS: A total of 20 702 hypertensive adults without a history of major cardiovascular disease were randomly assigned to a double-blind daily treatment of an enalapril 10-mg and a folic acid 0...
October 11, 2016: Stroke; a Journal of Cerebral Circulation
Bin Yang, Ping Yan, Hui Gong, Lin Zuo, Ying Shi, Jian Guo, Rui Guo, Jun Xie, Bao Li
Myocyte apoptosis is a key determinant of cardiac recovery and prognosis of patients with acute myocardial infarction (AMI). Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK), a member of TNF superfamily, is a pro-inflammatory and pro-angiogenic cytokine implicated in physiological tissue regeneration and wound repair and is closely related to cardiac remodeling, dysfunction and fibrosis. However, the role of TWEAK and its receptor Fn14 in the cardiomyocyte apoptosis is still poorly understood...
2016: American Journal of Translational Research
Hong Wu, Yan-Hu Liu, Guo-Dong Wang, Chun-Tao Yang, Newton O Otecko, Fei Liu, Shi-Fang Wu, Lu Wang, Li Yu, Ya-Ping Zhang
Genome-wide studies on high-altitude adaptation have received increased attention as a classical case of organismal evolution under extreme environment. However, the current genetic understanding of high-altitude adaptation emanated mainly from autosomal analyses. Only a few earlier genomic studies paid attention to the allosome. In this study, we performed an intensive scan of the X chromosome of public genomic data generated from Tibetan Mastiff (TM) and five other dog populations for indications of high-altitude adaptation...
October 7, 2016: Scientific Reports
Wei Liu, Zui Zou, Xin Huang, Hui Shen, Li Juan He, Si Min Chen, Li Ping Li, Lan Yan, Shi Qun Zhang, Jun Dong Zhang, Zheng Xu, Guo Tong Xu, Mao Mao An, Yuan Ying Jiang
Glycosylphosphatidyl inositol anchored proteins (GPI-APs) on fungal cell wall are essential for invasive infections. While the function of inositol deacylation of GPI-APs in mammalian cells has been previously characterized the impact of inositol deacylation in fungi and implications to host infection remains largely unexplored. Herein we describe our identification of BST1, an inositol deacylase of GPI-Aps in Candida albicans, was critical for GPI-APs cell wall attachment and host infection. BST1-deficient C...
October 6, 2016: Scientific Reports
Cheng-Zuo Xiao, Wei Wei, Zhi-Xing Guo, Mei-Yin Zhang, Yong-Fa Zhang, Jia-Hong Wang, Ming Shi, Hui-Yun Wang, Rong-Ping Guo
PURPOSE: Our previous miRNA profiling study indicated that microRNA-34c-3p (miR-34c-3p) was overexpressed and associated with survival in HCC. This study is aimed to confirm its clinical significance and explore the function and underlying mechanism of miR-34c-3p in HCC. METHODS: We first evaluated miR-34c-3p expression and its relationship with prognosis in HCC patients. We then established stable HCC cell lines with miR-34c-3p overexpression and knockdown by the lentiviral packaging systems and performed the functional assays in vitro and in vivo, respectively...
October 4, 2016: Journal of Cancer Research and Clinical Oncology
Ling-Hao Zhao, Xiao Liu, He-Xin Yan, Wei-Yang Li, Xi Zeng, Yuan Yang, Jie Zhao, Shi-Ping Liu, Xue-Han Zhuang, Chuan Lin, Chen-Jie Qin, Yi Zhao, Ze-Ya Pan, Gang Huang, Hui Liu, Jin Zhang, Ruo-Yu Wang, Yun Yang, Wen Wen, Gui-Shuai Lv, Hui-Lu Zhang, Han Wu, Shuai Huang, Ming-Da Wang, Liang Tang, Hong-Zhi Cao, Ling Wang, T P Lee, Hui Jiang, Ye-Xiong Tan, Sheng-Xian Yuan, Guo-Jun Hou, Qi-Fei Tao, Qin-Guo Xu, Xiu-Qing Zhang, Meng-Chao Wu, Xun Xu, Jun Wang, Huan-Ming Yang, Wei-Ping Zhou, Hong-Yang Wang
Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration detection and RNA sequencing, we identify 4,225 HBV integration events in tumour and adjacent non-tumour samples from 426 patients with HCC. We show that HBV is prone to integrate into rare fragile sites and functional genomic regions including CpG islands. We observe a distinct pattern in the preferential sites of HBV integration between tumour and non-tumour tissues...
October 5, 2016: Nature Communications
Yong-Fa Zhang, Jie Zhou, Wei Wei, Ru-Hai Zou, Min-Shan Chen, Wan Yee Lau, Ming Shi, Rong-Ping Guo
BACKGROUND: The subgroups of patients with intermediate-stage (BCLC-B) hepatocellular carcinoma (HCC) who would truly benefit from hepatic resection (HR) are unknown. An objective point score was established to guide the selection of these patients for HR. METHODS: In all, 255 consecutive patients with intermediate-stage HCC treated with HR were evaluated retrospectively and included in this study (the training cohort). The variables on overall survival (OS, log-rank test) were investigated and a point score (the NSP score) was developed by using a Cox-regression model and validated in an independent external cohort from another institution (n=169)...
October 4, 2016: British Journal of Cancer
Hua-Jie Liu, Shi-Bo Fang, Si-Wa Liu, Liang-Cheng Zhao, Xiu-Ping Guo, Yun-Jun Jiang, Jian-Sen Hu, Xiao-Di Liu, Yu Xia, Yi-Dan Wang, Qing-Feng Wu
To test the applicability of lichens in the biomonitoring of atmospheric elemental deposition in a typical steppe zone of Inner Mongolia, China, six foliose lichens (Physcia aipolia, PA; P. tribacia, PT; Xanthoria elegans, XE; X. mandschurica, XM; Xanthoparmelia camtschadalis, XPC; and Xp. tinctina, XPT) were sampled from the Xilin River Basin, Xilinhot, Inner Mongolia, China. Twenty-five elements (Al, Ba, Cd, Ce, Cr, Cs, Cu, Fe, K, La, Mn, Mo, Na, Ni, P, Pb, Sb, Sc, Sm, Tb, Th, Ti, Tl, V and Zn) in the lichens were analysed using inductively coupled plasma mass spectrometry (ICP-MS)...
October 4, 2016: Scientific Reports
Kaizhi Gu, Yajing Liu, Zhiqian Guo, Cheng Lian, Chenxu Yan, Ping Shi, He Tian, Wei-Hong Zhu
Leucine aminopeptidase (LAP), one of the important proteolytic enzymes, is intertwined with the progress of many pathological disorders as a well-defined biomarker. To explore fluorescent aminopeptidase probe for quantitative detection of LAP distribution and dynamic changes, herein we report a LAP-targeting near-infrared (NIR) fluorescent probe (DCM-Leu) for ratiometric quantitative trapping of LAP activity in different kinds of living cells. DCM-Leu is composed of a NIR-emitting fluorophore (DCM) as a reporter and l-leucine as a triggered moiety, which are linked together by an amide bond specific for LAP cleavage...
October 3, 2016: ACS Applied Materials & Interfaces
Qi Pei, Lu Huang, Jie Huang, Jing-Kai Gu, Yun Kuang, Xiao-Cong Zuo, Jun-Jie Ding, Hong-Yi Tan, Cheng-Xian Guo, Shi-Kun Liu, Guo-Ping Yang
AIM: Iloperidone is an atypical antipsychotic drug that is mainly metabolized by CYP2D6, CYP3A4, and cytosolic enzymes. Previous studies show that extensive and poor metabolizers of CYP2D6 exhibit different plasma concentrations of iloperidone and its metabolites. The aim of this study was to develop a parent-metabolite population pharmacokinetic (PPK) model to quantify the effects of CYP2D6(*)10 allele on the pharmacokinetics of iloperidone and its metabolites in Chinese schizophrenia patients...
September 26, 2016: Acta Pharmacologica Sinica
Ni Wang, Yan Ma, Yu Hong Liu, Jian DU, Hui Zhang, Shi Heng Xie, Kun Zhu, Xiao Ya Lyu, Wei Shu, Hong Hong Wang, Guo Feng Zhu, Shou Yong Tan, Yan Yong Fu, Li Ping Ma, Lian Ying Zhang, Fei Ying Liu, Dai Yu Hu, Yan Ling Zhang, Xiang Qun Li, Liang Li
The objective of this prospective study of the risks of treatment failure in patients with drug-susceptible pulmonary tuberculosis (PTB) was to provide reference data to help develop a disease control strategy. Participants were recruited in eight provinces of China from October 2008 to December 2010. A total of 1447 patients with drug-susceptible PTB and older than 15 years of age were enrolled. Demographic characteristics, bacteriological test results, and patient outcome, i.e., cure or treatment failure were recorded and compared using the chi-square or Fisher's exact tests...
August 2016: Biomedical and Environmental Sciences: BES
Marjo M P C Donners, Lili Bai, Suzanne P M Lutgens, Erwin Wijnands, Jason Johnson, Leon J Schurgers, Cong-Lin Liu, Mat J A P Daemen, Kitty B J M Cleutjens, Guo-Ping Shi, Erik A L Biessen, Sylvia Heeneman
Cathepsin K (catK) is a potent lysosomal cysteine protease involved in extracellular matrix (ECM) degradation and inflammatory remodeling responses. Here we have investigated the contribution of catK deficiency on carotid arterial remodeling in response to flow cessation in apoE-/- and wild type (wt) background. Ligation-induced hyperplasia is considerably aggravated in apoE-/- versus wt mice. CatK protein expression was significantly increased in neointimal lesions of apoE-/- compared with wt mice, suggesting a role for catK in intimal hyperplasia under hyperlipidemic conditions...
2016: PloS One
Yong Fan, Yong Li, Yan Chen, Yi-Jing Zhao, Li-Wei Liu, Jin Li, Shi-Lei Wang, Raphael N Alolga, Yin Yin, Xiang-Ming Wang, Dong-Sheng Zhao, Jian-Hua Shen, Fan-Qi Meng, Xin Zhou, Hao Xu, Guo-Ping He, Mao-De Lai, Ping Li, Wei Zhu, Lian-Wen Qi
BACKGROUND: Pathogenesis and diagnostic biomarkers for diseases can be discovered by metabolomic profiling of human fluids. If the various types of coronary artery disease (CAD) can be accurately characterized by metabolomics, effective treatment may be targeted without using unnecessary therapies and resources. OBJECTIVES: The authors studied disturbed metabolic pathways to assess the diagnostic value of metabolomics-based biomarkers in different types of CAD. METHODS: A cohort of 2,324 patients from 4 independent centers was studied...
September 20, 2016: Journal of the American College of Cardiology
Hong-Zhi Wang, Cai-Neng Cao, Jing-Wei Luo, Jun-Lin Yi, Xiao-Dong Huang, Shi-Ping Zhang, Kai Wang, Yuan Qu, Jian-Ping Xiao, Su-Yan Li, Li Gao, Guo-Zhen Xu
BACKGROUND: Although parotid-sparing IMRT decreased the dose distribution of parotid, parotid region recurrence has been reported. Prophylactic irradiation in parotid area would be necessary in patients with high risk of parotid lymph node metastasis (PLNM). This study was to detect the high-risk factors of PLNM in nasopharyngeal carcinoma. METHODS: This was a 1:2 case-control study. All patients in this study were newly diagnosed NPC with N2-3 classification from January 2005 to December 2012...
2016: Radiation Oncology
Huan-Bin Shi, Guo-Qing Chen, Ya-Ping Chen, Bo Dong, Jian-Ping Lu, Xiao-Hong Liu, Fu-Cheng Lin
The ubiquitin system modulates protein functions through targeting substrates for ubiquitination. Here, E2 conjugating enzyme MoRad6-related ubiquitination pathways are identified and analyzed in Magnaporthe oryzae, the causal agent of rice blast disease. Disruption of MoRad6 leads to severe defects in growth, sporulation, conidial germination, appressorium formation, and plant infection. To depict the functions of MoRad6, three putative ubiquitin ligases, MoRad18, MoBre1 and MoUbr1, are also characterized...
August 31, 2016: Environmental Microbiology
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