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Cold agglutinins

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https://www.readbyqxmd.com/read/28097289/binding-of-cll-subset-4-b-cell-receptor-immunoglobulins-to-viable-human-memory-b-lymphocytes-requires-a-distinctive-igkv-somatic-mutation
#1
Rosa Catera, Yun Liu, Chao Gao, Xiao-Jie Yan, Amanda Magli, Steven L Allen, Jonathan E Kolitz, Kanti R Rai, Charles C Chu, Ten Feizi, Kostas Stamatopoulos, Nicholas Chiorazzi
Amino acid replacement mutations in certain CLL stereotyped B-cell receptor (BCR) immunoglobulins (IGs) at defined positions within antigen-binding sites strongly imply antigen selection. Prime examples of this are CLL subset 4 BCR IGs using IGHV4-34/IGHD5-18/IGHJ6 and IGKV2-30/IGKJ2 rearrangements. Conspicuously and unlike most CLL IGs, subset 4 IGs do not bind apoptotic cells. By testing the (auto)antigenic reactivities of subset 4 IGs toward viable lymphoid-lineage cells and specific autoantigens typically bound by IGHV4-34(+) IGs, we found IGs from both subset 4 and non-subset 4 IGHV4-34-expressing CLL cases bind naïve B cells...
January 12, 2017: Molecular Medicine
https://www.readbyqxmd.com/read/27913484/cold-agglutinin-disease
#2
Sigbjørn Berentsen
Primary chronic cold agglutinin disease (CAD) is a well-defined clinicopathologic entity in which a specific, clonal lymphoproliferative B-cell bone marrow disorder results in autoimmune hemolytic anemia. The immune hemolysis is entirely complement-dependent, predominantly mediated by activation of the classical pathway and phagocytosis of erythrocytes opsonized with complement protein C3b. Typical clinical features in CAD have diagnostic and therapeutic implications. Pharmacologic treatment should be offered to patients with symptom-producing anemia or disabling circulatory symptoms...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27848264/underlying-mechanism-and-specific-prevention-of-hemolysis-induced-platelet-activation
#3
Thomas Gremmel, Simone Fedrizzi, Günter Weigel, Beate Eichelberger, Simon Panzer
Thromboembolic complications significantly impair the outcome of hemolytic disorders. We hypothesized that red cell adenosine diphosphate (ADP) release results in significant platelet activation in hemolysis and that this prothrombotic state can be prevented by inhibition of the ADP P2Y12 receptor. In the current study, we therefore sought to investigate the mechanism and inhibition of hemolysis-induced platelet activation. The expression of activated integrin αIIbß3 was determined by flow cytometry, and platelet aggregation was assessed by multiple electrode platelet aggregometry...
November 16, 2016: Platelets
https://www.readbyqxmd.com/read/27830112/mycoplasma-pneumonia-with-persistent-lymphadenopathy-and-severe-cold-agglutinin-haemolysis
#4
Mit Shah, Sajid Khan, Kenneth Chan
Mycoplasma pneumonia is an atypical pneumonia commonly affecting young patients with generally mild clinical course. We present a case of a 66-year-old female presenting with weight loss, night sweats and low-grade pyrexia. She acquired symptomatic haemolytic anaemia requiring blood transfusion, markedly raised erythrocyte sedimentation rate (ESR) to 114 mm/hr and extensive peri-hilar lymphadenopathy on computed tomography (CT) scan. After excluding malignancy and granulomatous diseases, she made good recovery although a 4 week follow-up CT scan showed persistent but resolving lymphadenopathy...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27827519/perioperative-management-of-a-patient-with-cold-agglutinin-disease-undergoing-segmental-hepatectomy
#5
Xuezhao Cao, Paul F White, Hong Ma
No abstract text is available yet for this article.
November 9, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27759698/occlusive-nonvasculitic-vasculopathy-a-review
#6
Mar Llamas-Velasco, Victoria Alegría, Ángel Santos-Briz, Lorenzo Cerroni, Heinz Kutzner, Luis Requena
We review the most characteristic clinical and histopathologic findings of the cutaneous manifestations of the occlusive nonvasculitic vasculopathic disorders. Clinically, most of these conditions are characterized by retiform purpura. Histopathologic findings consist of occlusion of the vessel lumina with no vasculitis. Different disorders may produce nonvasculitic occlusive vasculopathy in cutaneous blood and lymphatic vessels, including embolization due to cholesterol and oxalate emboli, cutaneous intravascular metastasis from visceral malignancies, atrial myxomas, intravascular angiosarcoma, intralymphatic histiocytosis, intravascular lymphomas, endocarditis, crystal globulin vasculopathy, hypereosinophilic syndrome, and foreign material...
October 18, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27728307/coomb-s-negative-cold-agglutinin-disease-secondary-to-mycoplasma-pneumonia
#7
Prem Kumar Aluka, Dilip M Rampure
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728294/two-case-reports-of-autoimmune-haemolytic-anaemia-cold-agglutinin-type
#8
Amal Dev D, Abraham Varghese, Sunil Mathew, P Viswanathan
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27716293/combined-integrated-protocol-basket-trial-design-for-a-first-in-human-trial
#9
Ulla Derhaschnig, Jim Gilbert, Ulrich Jäger, Georg Böhmig, Georg Stingl, Bernd Jilma
BACKGROUND: Innovative trial designs are sought to streamline drug development in rare diseases. Basket- and integrated protocol designs are two of these new strategies and have been applied in a handful oncologic trials. We have taken the concept outside the realm of oncology and report about a first-in-human integrated protocol design that facilitates the transition from phase Ia in healthy volunteers to phase Ib in patients with rare complement-mediated disorders driven by the classical pathway...
October 4, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27629968/postoperative-recurrence-of-invasive-thymoma-with-cold-agglutinin-disease-and-autoimmune-hemolytic-anemia
#10
Taro Yoneda, Hayato Koba, Kota Tanimura, Naohiko Ogawa, Satoshi Watanabe, Johsuke Hara, Miki Abo, Takashi Sone, Hideharu Kimura, Kazuo Kasahara
A 50-year-old man presented to our hospital in 1995. Invasive thymoma was diagnosed and extended thymectomy and left upper lobe partial resection were performed. In 2013, he complained of dyspnea. Chest computed tomography showed postoperative recurrence of invasive thymoma. Several chemotherapies were administered. Severe anemia and an increase in the total bilirubin level were observed with chemotherapies. In additional, an examination showed that the direct Coombs test was positive. Cold agglutinin was also high...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27624931/incidental-cold-agglutinins-in-cardiac-surgery-intraoperative-surprises-and-team-based-problem-solving-strategies-during-cardiopulmonary-bypass
#11
Prakash A Patel, Kamrouz Ghadimi, Ettienne Coetzee, Adriaan Myburgh, Justiaan Swanevelder, Jacob T Gutsche, John G T Augoustides
No abstract text is available yet for this article.
June 18, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27605855/anti-ih-an-antibody-worth-mention
#12
Nithya Mohanan, Nittin Henry, Aboobacker Mohamed Rafi, Susheela J Innah
A 72-year-old female with co-morbidities posted for surgical correction of fracture neck of femur without any history of transfusions was noted to have a hemoglobin level of 7 g/dl and packed red blood cells transfusion was ordered. Pretransfusion tests demonstrated A1B group with D positive on forward grouping. Reverse grouping showed a varying grade of agglutination with A, B, and O cells. Agglutination being stronger at 4°C. Antibody screening showed pan-agglutination, direct Coomb's test and auto control were negative...
July 2016: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/27578899/bentall-surgery-in-a-patient-with-cold-agglutinin-and-antiphospholipid-antibody-double-trouble
#13
Monish S Raut, Gulshan Rohra, Ganesh Shivnani, Arun Maheshwari, Sumir Dubey, Rajpal Singh Bhathiwal, Deevakar Sharma
Cold agglutinin disease is an uncommon disease with potential to cause hemolysis and thrombosis during hypothermic cardiac surgery. Antiphospholipid syndrome is also rare disease with hypercoagulation tendacy. Perioperative management of both these diseases is challenging. We present successful perioperative management of high risk Bentall surgery in patient with both these dreadful diseases.
June 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27578898/cold-agglutinin-autoantibodies-in-a-patient-without-a-visible-coronary-sinus-ostium-strategies-for-myocardial-protection-without-using-retrograde-cardioplegia
#14
Michele Heath, Suraj Yalamuri, Julie Walker, Cory Maxwell, Adam Williams, Sharon McCartney, Mani Daneshmand
The presence of cold agglutinins (CA) during cardiac surgery with cardiopulmonary bypass usually creates the need for an altered surgical plan. In this case, the CA were discovered after the initiation of bypass, limiting the time, and cardioplegia solutions that could be used in the new approach. The inability to cannulate the coronary sinus with a retrograde cardioplegia catheter excluded the standard approach to myocardial preservation with CA of using continuous warm blood. For this case, we used intermittent cold crystalloid delivered via the antegrade needle for the first half of the procedure and through the saphenous vein graft anastomosis during the aortic valve portion of the cross-clamp period...
June 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27547154/use-of-an-intravascular-warming-catheter-during-off-pump-coronary-artery-bypass-surgery-in-a-patient-with-severe-cold-hemagglutinin-disease
#15
Ashok Tholpady, Arthur W Bracey, Kelty R Baker, Ross M Reul, Alice J Chen
Cold hemagglutinin disease with broad thermal amplitude and high titers presents challenges in treating cardiac-surgery patients. Careful planning is needed to prevent the activation of cold agglutinins and the agglutination of red blood cells as the patient's temperature drops during surgery. We describe our approach to mitigating cold agglutinin formation in a 77-year-old man with severe cold hemagglutinin disease who underwent off-pump coronary artery bypass surgery without the use of preoperative plasmapheresis...
August 2016: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/27506562/acute-pancreatitis-and-pneumonia-due-to-mycoplasma-pneumoniae-a-case-report
#16
Michael Benzaquen, Dan Lebowitz, Pauline Belenotti, Jean-Marc Durand, Jacques Serratrice
BACKGROUND: Mycoplasma pneumoniae is a bacterium responsible for 15 to 40 % of acute community-acquired pneumonia in children and 20 % of adult cases. Several extrapulmonary manifestations have been reported. We report a rare case of an adult patient suffering from pneumonia associated with an acute pancreatitis in the setting of Mycoplasma pneumoniae infection. CASE PRESENTATION: A 28-year-old Caucasian woman was referred for anorexia lasting for 1 week. Her past medical history was notable for congenital hydrocephalus with consecutive ventriculo-peritoneal shunt, epilepsia and paraparesis...
August 9, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27498258/cardiopulmonary-bypass-management-complicated-by-a-stenotic-coronary-sinus-and-cold-agglutinins
#17
Suraj Yalamuri, Michele Heath, Sharon McCartney, Tera Cushman, Cory Maxwell
No abstract text is available yet for this article.
March 10, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27408415/resolution-of-serologic-problems-due-to-cold-agglutinins-in-chronic-lymphocytic-leukemia
#18
Rizwan Javed, Suvro Sankha Datta, Sabita Basu, Anupam Chakrapani
INTRODUCTION: Autoimmune hemolytic anemia can be classified depending on presence of warm, cold or mixed type of autoantibodies that are directed against antigens on the red blood cell surface. Here we report a case of pathological cold agglutinin disease which was eventually detected due to blood group discrepancy. CASE DETAILS: A request was sent to the blood bank for two units of packed red cells in a diagnosed case of CLL which showed type IV discrepancy during blood grouping...
June 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27408394/blood-group-discrepancy-first-sign-of-autoimmune-hemolytic-anemia-after-hematopoietic-stem-cell-transplantation-in-a-child
#19
Suvro Sankha Datta, Mahua Reddy, Sabita Basu, Shekhar Krishnan
A 12-year-old male child was presented in the emergency with features of anemia and mild icterus on day+67 of HSCT. The child was suffering from Fanconi anemia and undergone HSCT from ABO-matched, fully HLA matched sibling donor. The diagnosis of mixed type AIHA due to cytomegalovirus reactivation was made in the immunohematology laboratory and blood group discrepancy was the first sign of AIHA in this patient. Though the cold agglutinin titer was not significant but the clinical symptoms and laboratory evidences were suggestive of significant hemolysis due to underlying IgG autoantibody...
June 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27382552/clinical-characteristics-and-treatment-outcomes-of-primary-autoimmune-hemolytic-anemia-a-single-center-study-from-south-india
#20
Raghuveer Prabhu, Renjitha Bhaskaran, Veena Shenoy, Rema G, Neeraj Sidharthan
BACKGROUND: Autoimmune hemolytic anemia (AIHA) is a less recognized, potentially fatal condition. There is a scarcity of data on clinicoserological characteristics and response to therapy concerning this disease from South India. METHODS: Data for 33 patients with primary AIHA recorded from July 2009 to June 2015 were retrospectively analyzed for clinical presentation, response to frontline therapy, durability of response, time to next treatment (TTNT), and response to second-line agents...
June 2016: Blood Research
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