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Forensic Pathology Autopsy

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https://www.readbyqxmd.com/read/29127893/traumatic-fatal-aortic-rupture-in-motorcycle-drivers
#1
Guido Pelletti, Giovanni Cecchetto, Alessia Viero, Maria De Matteis, Guido Viel, Massimo Montisci
Traumatic fatal aortic rupture (FAR) is a common finding in victims of motor vehicle crashes (MVC), but its aetiology and mechanisms of production remain an issue of major concern, above all in motorcyclists. This study reports a series of cases obtained from a retrospective analysis of traumatic FARs occurring in motorcycle drivers, with the aim of defining the injury patterns and correlating them with the mechanisms of FAR production. Circumstantial, autopsy and histology data were collected through a retrospective analysis of post mortem examinations performed at the Institute of Legal Medicine of the University of Padova between 2014 and 2016...
November 6, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29118310/manifestation-of-coronary-atherosclerosis-in-klang-valley-malaysia-an-autopsy-study
#2
Razuin Rahimi, Mansharan Kaur Chainchel Singh, Norizal Mohd Noor, Effat Omar, Shahidan Md Noor, Mohd Shah Mahmood, Nurliza Abdullah, Hapizah Mohd Nawawi
AIMS: The present study aimed to determine the epidemiological aspects of medico-legal autopsies and manifestation of coronary atherosclerosis. METHODS: This was a cross sectional study involving 222 cases recruited from National Institute of Forensic Medicine (NIFM) Hospital Kuala Lumpur (HKL) and Department of Forensic Medicine Hospital Sungai Buloh (HSgB) for a period of 15 months, from December 2012 to April 2014. Sociodemographic and autopsy findings, including the cause and manner of death were documented...
November 8, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29101907/differences-between-postmortem-ct-and-autopsy-in-death-investigation-of-cervical-spine-injuries
#3
Yohsuke Makino, Hajime Yokota, Eiji Nakatani, Daisuke Yajima, Go Inokuchi, Ayumi Motomura, Fumiko Chiba, Suguru Torimitsu, Takashi Uno, Hirotaro Iwase
OBJECTIVES: To clarify the differences between postmortem CT (PMCT) and autopsy findings in the postmortem detection of cervical spine injuries (CSIs). MATERIALS AND METHODS: Our department's forensic pathology database was searched for CSI cases. In each case, the autopsy data and radiologists' interpretations were reviewed for the presence of bone fractures and intervertebral injuries. RESULTS: The study included 42 cases. For both bone fractures and intervertebral injuries, no substantial concordance between PMCT and autopsy findings was observed (McNemar's test: p<0...
October 28, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29016939/molecular-autopsy-of-sudden-unexplained-deaths-reveals-genetic-predispositions-for-cardiac-diseases-among-young-forensic-cases
#4
Nicole Hellenthal, Anna Gaertner-Rommel, Bärbel Klauke, Lech Paluszkiewicz, Markus Stuhr, Thoralf Kerner, Martin Farr, Klaus Püschel, Hendrik Milting
Aims: Coronary artery disease accounts for the majority of sudden cardiac deaths (SCD) in the older population whereas cardiomyopathies and arrhythmogenic abnormalities predominate in younger SCD victims (<35 years) with a significant genetic component. The elucidation of the pathogenetic cause of death might be relevant for the prevention of further deaths within affected families. Aim of this study was to determine the portion of underlying genetic heart diseases among unexplained putative SCD cases from a large German forensic department...
November 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28967810/scuba-diving-death-always-due-to-drowning-two-forensic-cases-and-a-review-of-the-literature
#5
I Aquila, F Pepe, M Manno, P Frati, S Gratteri, V Fineschi, P Ricci
Scuba diving is an increasingly common recreational activity. We describe the physiopathology of barotrauma in two cases where death was caused by pulmonary barotrauma while diving. An inspection and autopsy were carried out in both cases. The autopsy data were supported by post-mortem radiological investigation. Histological and toxicological analyses were also carried out, and dive computer and tank manometer analysis performed. In both cases, the cause of death was attributable to arterial gas embolism, resulting from pulmonary barotrauma subsequent to pulmonary over-distension...
January 1, 2017: Medico-legal Journal
https://www.readbyqxmd.com/read/28913415/forensic-pathology-education-in-pathology-residency-a-survey-of-current-practices-a-novel-curriculum-and-recommendations-for-the-future
#6
Amanda Spencer, Wayne K Ross, Ronald E Domen
Forensic pathology is a fundamental part of anatomic pathology training during pathology residency. However, the lack of information on forensic teaching suggests the highly variable nature of forensic education. A survey of pathology residency program directors was performed to determine key aspects of their respective forensic rotations and curriculum. A total of 38.3% of programs from across the country responded, and the survey results show 5.6% don't require a forensic pathology rotation. In those that do, most forensic pathology rotations are 4 weeks long, are done at a medical examiner's office, and require set prerequisites...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28889247/guidelines-for-autopsy-investigation-of-sudden-cardiac-death-2017-update-from-the-association-for-european-cardiovascular-pathology
#7
Cristina Basso, Beatriz Aguilera, Jytte Banner, Stephan Cohle, Giulia d'Amati, Rosa Henriques de Gouveia, Cira di Gioia, Aurelie Fabre, Patrick J Gallagher, Ornella Leone, Joaquin Lucena, Lubov Mitrofanova, Pilar Molina, Sarah Parsons, Stefania Rizzo, Mary N Sheppard, Maria Paz Suárez Mier, S Kim Suvarna, Gaetano Thiene, Allard van der Wal, Aryan Vink, Katarzyna Michaud
Although sudden cardiac death (SCD) is one of the most important modes of death in Western countries, pathologists and public health physicians have not given this problem the attention it deserves. New methods of preventing potentially fatal arrhythmias have been developed and the accurate diagnosis of the causes of SCD is now of particular importance. Pathologists are responsible for determining the precise cause and mechanism of sudden death but there is still considerable variation in the way in which they approach this increasingly complex task...
September 9, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28886207/the-biological-effects-of-kambo-is-there-a-relationship-between-its-administration-and-sudden-death
#8
Isabella Aquila, Santo Gratteri, Matteo A Sacco, Vittorio Fineschi, Simona Magi, Pasqualina Castaldo, Graziella Viscomi, Salvatore Amoroso, Pietrantonio Ricci
Kambo is a substance obtained from the skin secretions of a frog, Phyllomedusa bicolor, popular in the Amazon region, which is administered via the transdermal route. We report a case of 42-year-old man found dead in his house. Near the corpse, a plastic box labeled as "Kambo sticks" was found. The man was a chronic consumer of Kambo and no previous pathology or genetic disease emerged in clinical history from the declaration of his general practitioner. Autopsy investigations and toxicological analysis were performed...
September 8, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28866283/traumatic-brain-injury-comparison-between-autopsy-and-ante-mortem-ct
#9
Stephanie Panzer, Lidia Covaliov, Peter Augat, Oliver Peschel
PURPOSE: The aim of this study was to compare pathological findings after traumatic brain injury between autopsy and ante-mortem computed tomography (CT). A second aim was to identify changes in these findings between the primary posttraumatic CT and the last follow-up CT before death. METHODS: Through the collaboration between clinical radiology and forensic medicine, 45 patients with traumatic brain injury were investigated. These patients had undergone ante-mortem CT as well as autopsy...
August 26, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28828513/-postmortem-imaging-procedures-experiences-and-perspectives
#10
REVIEW
S von Stillfried, P Isfort, R Knüchel-Clarke
Autopsies are of key importance for the understanding of the anatomy, pathophysiology and pathomorphology. In forensic medicine, the virtual autopsy is a standard instrument in autopsy practice. The advantage of postmortem imaging is the generation of a three-dimensional pre-autopsy snapshot of the body from head to toe with excellent visualization of skeletal pathologies and air inclusions. When angiography is performed, pathologies of the cardiovascular system can additionally be evaluated. The shortcomings of postmortem imaging are the low soft tissue contrast with CT imaging, the lack of haptic, olfactory and color impressions...
September 2017: Der Pathologe
https://www.readbyqxmd.com/read/28795313/-autopsies-at-the-boundary-between-pathology-and-forensic-medicine-suggestions-for-interdisciplinary-cooperation
#11
REVIEW
T Riepert
There are many differences between forensic medicine and pathology but also many similarities, as they share a common basis. In this article the characteristics of the forensic autopsy and it's legal foundations are presented. Furthermore, possibilities are discussed for a cooperation between forensic medicine and pathology to increase the rate of autopsies. This could contribute to the legal certainty, to the quality assurance and to the training of physicians.
September 2017: Der Pathologe
https://www.readbyqxmd.com/read/28776465/dna-testing-in-homicide-investigations
#12
Joseph A Prahlow, Thomas Cameron, Alexander Arendt, Kenneth Cornelis, Anthony Bontrager, Michael S Suth, Lisa Black, Rebbecca Tobey, Sharon Pollock, Shawn Stur, Kenneth Cotter, Joel Gabrielse
Objectives With the widespread use of DNA testing, police, death investigators, and attorneys need to be aware of the capabilities of this technology. This review provides an overview of scenarios where DNA evidence has played a major role in homicide investigations in order to highlight important educational issues for police, death investigators, forensic pathologists, and attorneys. Methods This was a nonrandom, observational, retrospective study. Data were obtained from the collective files of the authors from casework during a 15-year period, from 2000 through 2014...
January 1, 2017: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/28776218/molecular-pathology-of-cerebral-tnf-%C3%AE-il-1%C3%AE-inos-and-nrf2-in-forensic-autopsy-cases-with-special-regard-to-deaths-due-to-environmental-hazards-and-intoxication
#13
Si-Hao Du, Xiao-Hui Tan, Rui Zhao, Dong Zhao, Ye Xue, Hui-Jun Wang, Xiao-Li Xie, Qi Wang
Deaths involved with environmental hazards and intoxication might present with minimal or nonspecific morphological features, which are insufficient to establish a diagnosis. The present study investigated the postmortem brain mRNA and immunohistochemical expressions of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS) and nuclear factor erythroid-2-related factor-2 (Nrf2) in forensic cases. Relative mRNA quantification using Taqman real-time PCR assay demonstrated higher expression of IL-1β, TNF-α and iNOS, and lower expression of Nrf2 in methamphetamine intoxication and hyperthermia cases, higher expression of iNOS in phenobarbital intoxication cases, and higher expression of Nrf2 in phenobarbital intoxication and hypothermia cases...
August 3, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28765973/differential-expression-of-b-type-natriuretic-peptide-between-left-and-right-ventricles-with-particular-regard-to-sudden-cardiac-death
#14
Zhi-Peng Cao, Jia-Jia Xue, Yuan Zhang, Mei-Hui Tian, Ying Xiao, Yu-Qing Jia, Bao-Li Zhu
The aim of the present study was to investigate the differential expression of B‑type natriuretic peptide (BNP) between the left and right ventricle (RV) in sudden cardiac death (SCD). A total of 26 forensic autopsy cases of sudden death (survival time <30 min, postmortem interval <48 h or frozen within 6 h following death) in the present institute were examined. The cases consisted of acute ischemic heart disease (AIHD, n=15) with/without apparent myocardial necrosis as a sign of infarction (acute myocardial infarction, n=6; ischemic heart disease, IHD, n=9), and arrhythmogenic right ventricular cardiomyopathy (ARVC/D, n=5), in addition to traffic accidents and high falls without any pre existing heart disease as control (C, total n=6)...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28752200/retrospective-analysis-of-769-cases-of-sudden-cardiac-death-from-2006-to-2015-a-forensic-experience-in-china
#15
Zijiao Ding, Mingzhen Yang, Yunyun Wang, Shifan Wu, Xingang Qiu, Qian Liu
Sudden cardiac death (SCD) is a major health challenge. The records of 769 autopsy cases of SCD examined at Tongji Medicolegal Expertise Center from January 2006 to December 2015 were retrospectively reviewed. The mean age of the cases was 46 years, excluding 27 victims in whom the exact age could not be confirmed. The highest incidence of SCD occurred among the 40- to 60-year-old group (45.0%). Male preponderance was observed in SCD cases (male: female ratio: 5.0:1), and this preponderance was even higher (8...
July 27, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28718912/survival-of-atherosclerotic-calcifications-in-skeletonized-material-forensic-and-pathological-implications
#16
Lucie Biehler-Gomez, Annalisa Cappella, Elisa Castoldi, Laurent Martrille, Cristina Cattaneo
Atherosclerosis is a chronic inflammatory disease creating calcifying plaques in the arterial walls. Because its paleopathological diagnosis remains little studied on skeletal remains, its impact on forensic and archeological data is completely underestimated. Here, 24 skeletal remains from the Milano Cemetery Skeletal Collection have been studied to evaluate the chance of atherosclerotic calcification survival, retrieval, and identification. Through direct comparison with a known autopsy collection and literature, the identification and categorization of several types of calcifications were performed...
July 18, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28704795/endocan-concentrations-in-postmortem-serum-vitreous-humor-and-urine-in-victims-of-lethal-hypothermia
#17
Emilienne Descloux, Marc Augsburger, Grzegorz Teresiński, Petr Hejna, Eric Grouzmann, Maria Pia Scarpelli, Tania Hervet, Cristian Palmiere
Endocan is a soluble molecule secreted from vascular endothelial cells of various organs. Its exact function in humans remains to be elucidated, though it has been postulated that increased tissue expression or serum levels of this molecule may be an indicator of endothelial activation and neovascularization. In the realm of forensic pathology, studies pertaining to endothelial activation following exposure to cold exclusively focused on thrombomodulin, a transmembrane protein specific to endothelial cells...
August 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28692478/diagnosis-of-vitality-in-skin-wounds-in-the-ligature-marks-resulting-from-suicide-hanging
#18
Isabel Legaz Pérez, Maria Falcón, M Gimenez, F Martínez Diaz, M D Pérez-Cárceles, E Osuna, D Nuno-Vieira, A Luna
Ascertaining the vital origin of skin wounds is one of the most challenging problems in forensic pathology. The forensic literature describes biomarkers and methods for differentiating vital and postmortem wounds, although no clear conclusions have been reached. The aim of this study was to characterize human vital wounds by analyzing the concentrations of metallic ions and the expression of P-selectin and cathepsin D in skin wounds in the ligature marks in a cohort of suicidal hangings for which vitality was previously demonstrated...
September 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28686962/forensic-aspects-of-homicides-by-insulin-overdose
#19
Fang Tong, Rongqi Wu, Wen Huang, Yi Yang, Lin Zhang, Biao Zhang, Xin Chen, Xiaohui Tang, Yiwu Zhou
Analysis of homicidal insulin overdose is a challenging task in forensic practice because of the difficulties in toxicological analysis as well as the elusive pathologic changes. We performed a detailed histopathologic examination on four autopsy cases involving insulin homicide, using H&E, immunohistochemistry (IHC) and immunofluorescence assays. Severe reactive astrocyte proliferation was obvious in the white matter of the cerebrum, corpus callosum, cerebellum and brain stem, especially in subcortical regions...
September 2017: Forensic Science International
https://www.readbyqxmd.com/read/28674960/autopsy-histopathology-where-the-prosector-is-not-a-histopathologist-a-proposal
#20
Mohammed Madadin, Rihab Molah, Stephen Cordner
Forensic pathology is a specialty that involves death investigation while clinical forensic medicine is the application of the practice of medicine to the requests of the law in relation to the living. Around the world, there is diverse practice for these two disciplines. The forensic physician or forensic doctor (sometimes, called a forensic pathologist but not a forensic histopathologist) in parts of the world such as continental Europe, the Middle East and India, practice both clinical forensic medicine and forensic pathology...
July 3, 2017: Forensic Science, Medicine, and Pathology
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