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Forensic Pathology Autopsy

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https://www.readbyqxmd.com/read/28176637/personalized-medicine-applied-to-forensic-sciences-new-advances-and-perspectives-for-a-tailored-forensic-approach
#1
Alessandro Santurro, Anna Maria Vullo, Marina Borro, Giovanna Gentile, Raffaele La Russa, Maurizio Simmaco, Paola Frati, Vittorio Fineschi
Personalized medicine (PM), included in P5 medicine (Personalized, Predictive, Preventive, Participative and Precision medicine) is an innovative approach to the patient, emerging from the need to tailor and to fit the profile of each individual. PM promises to dramatically impact also on forensic sciences and justice system in ways we are only beginning to understand. The application of omics (genomic, transcriptomics, epigenetics/imprintomics, proteomic and metabolomics) is ever more fundamental in the so called "molecular autopsy"...
February 7, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28122325/demographic-clinical-and-pathological-features-of-sudden-deaths-due-to-myocarditis-results-from-a-state-wide-population-based-autopsy-study
#2
Liliang Li, Yang Zhang, Allen Burke, Aimin Xue, Ziqin Zhao, David Fowler, Yiwen Shen, Ling Li
Causes of sudden cardiac deaths have been widely reported with limited data focused specifically on myocarditis. A retrospective review of cases from the Office of the Chief Medical Examiner (OCME), State of Maryland yielded a total of 103 sudden unexpected deaths (SUDs) due to myocarditis (0.17% of all SUDs and 0.70% of autopsied SUDs) from 2005 through 2014. Most deaths occurred in patients <30 years of age with a male:female ratio 1.3:1. Of the 103 cases, 45 (43.7%) patients were witnessed collapsed. Four deaths occurred during exertion, such as exercising at the gym or performing heavy physical work, and 2 deaths were associated with emotional stress...
January 3, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28064358/incipient-progressive-supranuclear-palsy-is-more-common-than-expected-and-may-comprise-clinicopathological-subtypes-a-forensic-autopsy-series
#3
Koji Yoshida, Yukiko Hata, Koshi Kinoshita, Shutaro Takashima, Kortaro Tanaka, Naoki Nishida
We investigated 998 serial Japanese forensic autopsy cases (0-101 years old, mean age 61.7 ± 21.9), with no case selection, using immunohistochemistry to detect cases with progressive supranuclear palsy (PSP). Twenty-nine cases (mean age 82.3 ± 7.2 years, 11 males, 18 females) fulfilled the National Institute of Neuronal Disorders and Stroke (NINDS)-PSP pathological criteria (2.9% of all cases, 4.6% of cases over 60). All had neuronal and glial inclusions in the basal ganglia and brainstem. However, 13 cases had low tau pathology and were categorized as atypical PSP...
January 7, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28056376/technical-note-a-preliminary-comparative-study-between-classical-and-interventional-radiological-approaches-for-multi-phase-post-mortem-ct-angiography
#4
Fatima-Zohra Mokrane, Frederic Savall, Laurent Dercle, Eric Crubezy, Norbert Telmon, Hervé Rousseau, Fabrice Dedouit
PURPOSE: Multi-phase post-mortem computed tomography angiography (MPMCTA) is a new diagnostic tool, used in forensic pathology. On the one hand, this technique allows a better and direct visualization of vascular and solid organ lesions. On the other hand, the invasiveness of the procedure-which requires surgical denudation (inguinal and/or cervical) and the insertion of surgical cannulas-leads to many relatives refusing scientific autopsies. Our hypothesis states that a minimally-invasive procedure combining interventional radiological techniques with MPMCTA (replacement of surgical cannulas by radiological catheters) will improve the approval rate of scientific autopsies by families...
December 19, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27994303/accessory-spleen-in-the-splenic-hilum-a-cadaveric-study-with-clinical-significance
#5
Shabnam Mohammadi, Arya Hedjazi, Maryam Sajjadian, Naser Ghrobi, Maliheh Dadgar Moghadam, Maryam Mohammadi
AIM: An accessory spleen is an additional tissue of the spleen that may be found near the spleen. It is a congenital anomaly of the spleen that its incidence has been reported 10-30% of the population. Hence, the objective of this study was evaluation the incidence of accessory spleen in Iranian cadavers. METHOD: Sixty hundred and ninety three spleens (541 males, 152 females) were excised from cadavers in the dissection hall of Mashhad Forensic Medicine Organization cadavers...
October 2016: Medical Archives
https://www.readbyqxmd.com/read/27933413/investigation-on-genetic-thrombophilic-factors-in-ffpe-autopsy-tissue-from-subjects-who-died-from-pulmonary-embolism
#6
Francesco Brandimarti, Federica Alessandrini, Mauro Pesaresi, Chiara Catalani, Letizia De Angelis, Roberta Galeazzi, Simona Giovagnetti, Rosaria Gesuita, Elisa Righi, Raffaele Giorgetti, Adriano Tagliabracci
Venous thromboembolism (VTE) is a multifactorial disease determined by a combination of inherited and acquired factors. Inherited factors include mutations in the genes coding for coagulation factors, some of which seem to exert a differential influence on the risk of developing deep vein thrombosis (DVT) and pulmonary embolism (PE). In post-mortem studies of subjects who have died from pulmonary embolism (PE), the analysis of the factors that may have augmented the VTE risk is often limited to acquired factors...
March 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27913880/forensic-3d-documentation-of-skin-injuries
#7
Chiara Villa
An accurate and precise documentation of injuries is fundamental in a forensic pathological context. Photographs and manual measurements are taken of all injuries during autopsies, but ordinary photography projects a 3D wound on a 2D space. Using technologies such as photogrammetry, it is possible to create 3D detailed, to-scale, true-color documentation of skin injuries from 2D pictures. A comparison between the measurements of 165 lesions taken during autopsies and on photogrammetrically processed pictures was performed...
December 2, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27766573/diagnosis-of-myocardial-ischemia-combining-multiphase-postmortem-ct-angiography-histology-and-postmortem-biochemistry
#8
Jessica Vanhaebost, Kewin Ducrot, Sébastien de Froidmont, Maria Pia Scarpelli, Coraline Egger, Pia Baumann, Gregory Schmit, Silke Grabherr, Cristian Palmiere
PURPOSE: The aim of this study was to assess whether the identification of pathological myocardial enhancement at multiphase postmortem computed tomography angiography was correlated with increased levels of troponin T and I in postmortem serum from femoral blood as well as morphological findings of myocardial ischemia. We further aimed to investigate whether autopsy cases characterized by increased troponin T and I concentrations as well as morphological findings of myocardial ischemia were also characterized by pathological myocardial enhancement at multiphase postmortem computed tomography angiography...
October 20, 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27763584/-forensic-medical-characteristic-of-the-causes-behind-sudden-death-in-the-young-subjects
#9
Yu I Pigolkin, M A Shilova, E M Kil'dyushov, Eksp Gal'chikov
The objective of the present study was to analyze the causes of sudden death in the general population and in the fraction of the young subjects (below 39 years of age). The results of the original retrospective study were obtained in the course of forensic medical autopsies of the subjects aged below 39 years that had been carried out during a period of 10 years. It was shown that one of the causes behind sudden death among the young subjects is cardiovascular disorders associated with the pre-existing pathological condition in the form of connective tissue dysplasia...
2016: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/27677633/forensic-postmortem-computed-tomography-volumetric-measurement-of-the-heart-and-liver
#10
Lykke Schrøder Jakobsen, Sissel Lundemose, Jytte Banner, Niels Lynnerup, Christina Jacobsen
PURPOSE: The purpose of this study was to investigate the utility of postmortem computed tomography (PMCT) images in estimating organ sizes and to examine the use of the cardiothoracic ratio (CTR). METHODS: We included 45 individuals (19 females), who underwent a medico-legal autopsy. Using the computer software program Mimics(®), we determined in situ heart and liver volumes derived from linear measurements (width, height and depth) on a whole body PMCT-scan, and compared the volumes with ex vivo volumes derived by CT-scan of the eviscerated heart and liver...
December 2016: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/27677096/the-institution-of-a-standardized-investigation-protocol-for-sudden-infant-death-in-the-eastern-metropole-cape-town-south-africa
#11
Johan J Dempers, Jean Coldrey, Elsie H Burger, Vonita Thompson, Shabbir A Wadee, Hein J Odendaal, Mary Ann Sens, Brad B Randall, Rebecca D Folkerth, Hannah C Kinney
The rate for the sudden infant death syndrome (SIDS) in Cape Town, South Africa, is estimated to be among the highest in the world (3.41/1000 live births). In several of these areas, including those of extreme poverty, only sporadic, nonstandardized infant autopsy, and death scene investigation (DSI) occurred. In this report, we detail a feasibility project comprising 18 autopsied infants with sudden and unexpected death whose causes of death were adjudicated according to the 1991 NICHD definitions (SIDS, n = 7; known cause of death, n = 7; and unclassified, n = 4)...
November 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27665272/old-hearts-for-modern-investigations-ct-and-mr-for-archaeological-human-hearts-remains
#12
F Z Mokrane, R Colleter, S Duchesne, P Gerard, F Savall, E Crubezy, C Guilbeau-Frugier, R Moreno, A Sewonu, H Rousseau, N Telmon, F Dedouit
INTRODUCTION: Among 800 burials dated between the 15th and 18th centuries and found in the center of Rennes (Brittany, France), a collection of five heart-shaped lead urns was discovered. This material was studied using classical methods (external study, autopsy and histology), and also modern imaging like computed tomography (CT), magnetic resonance (MR) before and after coronary opacification. The aim of this manuscript is to describe different steps of ancient soft tissues study, especially using imaging techniques...
November 2016: Forensic Science International
https://www.readbyqxmd.com/read/27651022/molecular-pathology-of-pulmonary-edema-in-forensic-autopsy-cases-with-special-regard-to-fatal-methamphetamine-intoxication
#13
Yu Du, Hong-Nian Jin, Rui Zhao, Dong Zhao, Ye Xue, Bao-Li Zhu, Da-Wei Guan, Xiao-Li Xie, Qi Wang
Pulmonary edema is a common finding in fatal methamphetamine intoxication. However, the underlying mechanism remains poorly understood. This study investigated the molecular pathology of alveolar damage involving pulmonary edema in forensic autopsy cases. Seven candidate reference genes (RPL13A, YWHAZ, GUSB, SDHA, GAPDH, B2M, and ACTB) were evaluated in the lung by the geNorm module in qBase(plus) software. RPL13A, YWHAZ, and GUSB were identified as the most stable reference genes. Using these validated reference genes, intrapulmonary mRNA expressions of matrix metalloproteinases (MMPs), intercellular adhesion molecule-1 (ICAM-1), claudin-5 (CLDN-5), and aquaporins (AQPs) were examined...
November 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27600776/-aortic-aneurysm-in-erdheim-s-idiopathic-cystic-medial-necrosis-in-autopsy-and-forensic-medical-practice
#14
O V Dolzhansky, M A Shilova, E M Pal'tseva, D N Fedorov, E Z Kocharyan, Yu I Pigolkin
UNLABELLED: To date, the modern Russian literature has not covered morphological studies of aortic aneurysm in Erdheim's idiopathic cystic medial necrosis on autopsy and surgical materials, by using immunohistochemical studies, and it has not estimated the magnitude of pathohistochemical changes in the aortic media either. AIM: to conduct a morphological examination of aortic aneurysm in Erdheim's idiopathic cystic medial necrosis, by using the material of pathology and forensic medical departments...
July 2016: Arkhiv Patologii
https://www.readbyqxmd.com/read/27591544/diagnosis-of-anaphylactic-death-in-forensics-review-and-future-perspectives
#15
REVIEW
Rossana Cecchi
The diagnosis of anaphylaxis in a pre- or post-mortal phase involves the formulation of problems not yet solved by the international scientific literature, due to the complexity of pathogenic factors and pathophysiological processes that characterizes it. For forensic autopsies, further problems of differential diagnosis arise and often leave the forensic pathologist unable to express an opinion of certainty, as a result of lack of case history, circumstantial and autoptical-histopathological data. Nevertheless, in routine cases the postmortem diagnosis of anaphylactic death continues to be based on exclusion and circumstantial evidence...
September 2016: Legal Medicine
https://www.readbyqxmd.com/read/27571170/current-analysis-of-hangings-that-deviates-from-recently-published-studies
#16
Leigh Hlavaty, William Kasper, LokMan Sung
The constellation of injuries observed in hangings is a subject receiving frequent review in forensic pathology literature. Whereas recent studies have reported high concordance between hangings and internal findings such as strap muscle hemorrhages and hyoid bone and thyroid cartilage fractures, a 2-part study examining autopsied suicidal hangings over a 9-year period at the Wayne County Medical Examiner's Office produced markedly differing results. Retrospectively and prospectively, external and internal autopsy observations were correlated with factors such as age, sex, body height, body mass index, ligature, and height of suspension...
December 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/27494040/injury-pattern-in-lethal-motorbikes-pedestrian-collisions-in-the-area-of-barcelona-spain
#17
M Carmen Rebollo-Soria, Carlos Arregui-Dalmases, David Sánchez-Molina, Juan Velázquez-Ameijide, Ignasi Galtés
INTRODUCTION: There are several studies about M1 type vehicle-pedestrian collision injury pattern, and based on them, there has been several changes in automobiles for pedestrian protection. However, the lack of sufficient studies about injury pattern in motorbikes-pedestrian collisions leads to a lack of optimization design of these vehicles. The objective of this research is to study the injury pattern of pedestrians involved in collisions with motorized two-wheeled vehicles. METHODS: A retrospective descriptive study of pedestrian's deaths after collisions with motorcycles in an urban area, like Barcelona was performed...
October 2016: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/27465122/post-mortem-magnetic-resonance-foetal-imaging-a-study-of-morphological-correlation-with-conventional-autopsy-and-histopathological-findings
#18
Annamaria Vullo, Valeria Panebianco, Giuseppe Cannavale, Mariarosaria Aromatario, Luigi Cipolloni, Paola Frati, Alessandro Santurro, Francesco Vullo, Carlo Catalano, Vittorio Fineschi
The aim of the present study is to offer our experience concerning post-mortem magnetic resonance (PMMR) in foetal death cases and an evaluation of the differences between the findings acquired by PMMR and by forensic autopsy. Fifteen foetuses were recruited from July 2014 to December 2015. These had suffered intrauterine death in women in the 21st to 38th week of gestation who were treated in the emergency department for non-perception of foetal movements. We performed a PMMR on foetuses, 3 ± 1 days on average from the time of death, and then a complete forensic autopsy was performed...
November 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27438022/fatal-heat-stroke-in-children-found-in-parked-cars-autopsy-findings
#19
Berliz Adato, Gal Dubnov-Raz, Hadas Gips, Yuval Heled, Yoram Epstein
UNLABELLED: A common and unfortunate cause for heat stroke-related deaths in children is entrapment in closed vehicles. The aim of this study was to analyze the pathological consequences of such grave events. Autopsy reports of all children that were brought to a national forensic medicine center after being found dead in closed vehicles over a 21-year period (1995-2015) were reviewed. Data extracted were the circumstances of the events, child age, sex, height and weight, time, date and duration of entrapment, and environmental temperatures at the time of entrapment and the autopsy findings...
September 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27404619/an-appraisal-of-decomposition-cases-received-at-the-johannesburg-forensic-pathology-service-medico-legal-mortuary-during-2010-2011
#20
Craig A Keyes, Lawrence Hill, Guinevere M Gordon
Decomposed bodies pose many questions for researchers regarding environmental effects, cause of death, and patterns. This study aimed to observe the factors associated with decomposed bodies autopsied at the Johannesburg Forensic Pathology Service Medico-legal Mortuary. A total of 4876 autopsies were conducted from 2010 to 2011, of which 109 were decomposed. Black individuals made up the largest proportion (67%) followed by White (26%). Males comprised 86.2%, while 12.8% were female. The mean age was 42.78 years...
March 2016: Journal of Forensic Sciences
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