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Forensic Pathology Autopsy

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https://www.readbyqxmd.com/read/28499667/insight-into-the-incidence-of-acute-aortic-dissection-in-the-german-region-of-berlin-and-brandenburg
#1
S D Kurz, V Falk, J Kempfert, M Gieb, T M Ruschinski, M Kukucka, M Tsokos, H Grubitzsch, H Herbst, J Semmler, C Buschmann
BACKGROUND: Stanford acute type A aortic dissection (ATAAD) is a potentially lethal condition. Epidemiology studies show a statistical incidence in Europe of approximately 2-16 cases/100,000 inhabitants/year. In Germany, the estimated incidence (here subsumed under "thoracic aortic dissection" with 4.63 cases/100,000 inhabitants/year) is mainly extracted from medical death certificates by the German Federal Statistical Office. The prehospital incidence of ATAAD deaths is largely unknown...
May 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28469515/hanging-fatalities-in-central-bangkok-thailand-a-13-year-retrospective-study
#2
Nattapong Tulapunt, Swarin Phanchan, Vichan Peonim
Hanging is violent asphyxial death. The objective of this study is to assess the data of hanging cases. A descriptive-retrospective study was conducted. We studied 244 hanging cases autopsied in Forensic Division, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, between January 2001 and December 2013. The study included 197 men (80.7%) and 47 women (19.2%). Their age ranged from 14 to 93 years. Most of these cases were incomplete hanging (83.6%). Features of hanging victims, such as tongue protrusion; congestion of face; petechial hemorrhage of face, conjunctiva, and internal organs; and neck injuries, significantly correlated with complete hanging...
2017: Clinical Medicine Insights. Pathology
https://www.readbyqxmd.com/read/28464277/forensic-case-reports-presenting-immersion-pulmonary-edema-as-a-differential-diagnosis-in-fatal-diving-accidents
#3
Julie Vinkel, Peter Bak, Peter Juel Thiis Knudsen, Ole Hyldegaard
Immersion Pulmonary Edema (IPE) reduces the transport of gases over the respiratory membrane due to edema in the interstitium and respiratory zones. IPE has previously been described in both swimmers and divers, with a few known fatal cases. We have reviewed 42 SCUBA and snorkeling-related drowning deaths, and through a thorough analysis of each case, including both diving physiology and forensic pathology, we present IPE as a differential diagnosis to drowning in four cases. Our findings propose that; absence of watery content in the stomach and conducting airways, and liquid filled lungs without hyperexpansion, may be compatible with IPE...
May 2, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28457512/sex-prediction-potential-of-hyoid-metric-measurements-in-iranian-adults
#4
Siamak Soltani, Kamran Aghakhani, Fardin Fallah
OBJECTIVES: Human hyoid is sexually dimorphic and is useful for sexing unknown skeletal remains. We aimed to find sex prediction potential of three linear dimensions of hyoid bones obtained from a series of cadavers with Persian ethnicity. METHODS: This cross-sectional study was carried out in 2015 at Forensic Pathology Organization of Tehran, Iran. We directly measured three linear dimensions of a series of hyoid samples obtained from cadavers during their neck autopsy in a convenience method...
March 2017: Legal Medicine
https://www.readbyqxmd.com/read/28439696/back-to-the-future-part-1-the-medico-legal-autopsy-from-ancient-civilization-to-the-post-genomic-era
#5
REVIEW
Giovanni Cecchetto, Thomas Bajanowski, Rossana Cecchi, Donata Favretto, Silke Grabherr, Takaki Ishikawa, Toshikazu Kondo, Massimo Montisci, Heidi Pfeiffer, Maurizio Rippa Bonati, Dina Shokry, Marielle Vennemann, Santo Davide Ferrara
Part 1 of the review "Back to the Future" examines the historical evolution of the medico-legal autopsy and microscopy techniques, from Ancient Civilization to the Post-Genomic Era. In the section focusing on "The Past", the study of historical sources concerning the origins and development of the medico-legal autopsy, from the Bronze Age until the Middle Ages, shows how, as early as 2000 BC, the performance of autopsies for medico-legal purposes was a known and widespread practice in some ancient civilizations in Egypt, the Far East and later in Europe...
April 24, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28342827/foreign-citizen-mortality-in-iceland-january-2006-december-2016
#6
S N Kunz, R Bingert
BACKGROUND: In recent years, tourism has become the number one account for foreign exchange income in Iceland, overtaking the fisheries industry and aluminium production. The rise of tourism has strongly affected Icelandic society in various sectors. With the increase of tourists visiting Iceland, the number of foreign citizens that died and were autopsied also rose. METHOD: Data were collected from the Department of Forensic Pathology at Landspitali University Hospital in Reykjavik for the period January 2006 - December 2016...
March 23, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28288337/remodelling-of-myocardial-intercalated-disc-protein-connexin-43-causes-increased-susceptibility-to-malignant-arrhythmias-in-arvc-d-patients
#7
Xiao Chen, Liang Chen, Zhenglian Chen, Xinshan Chen, Jiangping Song
BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a primary cardiomyopathy characterised by fibrofatty replacement and ventricular arrhythmias. The occurrence of malignant arrhythmias may be associated with fatty infiltration and intercalated disk remodelling, but the specific pathological remodelling pattern is not yet clear. METHODS: Twelve explanted hearts from patients diagnosed with ARVC/D according to the 2010 Task Force Criteria and pathology examination were divided into two groups with (SVT, n=6) or without (non-SVT, n=6) recurrent sustained ventricular tachycardia (SVT) before heart transplantation...
February 27, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28272089/mediators-of-inflammation-in-asthma-a-forensic-perspective
#8
Maria Laura Schirripa, Maria Pia Scarpelli, Cristian Palmiere
In the clinical setting, the role of systemic inflammation in patients with asthma has attracted increased attention, and some authors showed that increased IL-6 and high-sensitivity C-reactive protein characterized a group of asthmatic patients. In the realm of forensic pathology, a postmortem diagnosis of asthmatic death can be extremely challenging. The aim of this study was to determine the postmortem serum levels of C-reactive protein, IL-6, and tumor necrosis factor α in a series of severe acute bronchial asthma deaths that underwent medicolegal investigations...
June 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28252873/glucose-metabolism-in-completed-suicide-a-forensic-pathological-pilot-study
#9
Jonas Forsman, Terhi Keltanen, Benny Liberg, Antti Sajantila, Thomas Masterman, Katarina Lindroos
AIM: To determine whether antemortem blood levels of glycated hemoglobin (HbA1c) and glucose predict completed suicide and, by extension, whether markers of glucose metabolism might be associated with a prosuicidal trait or state. METHOD: From consecutively performed autopsies, samples of blood and vitreous humor from 17 suicide victims and 27 non-suicide controls were compared with regard to levels of glucose, lactate, and HbA1c. RESULTS: Mean HbA1c was higher, and mean estimated blood glucose lower, among suicide victims, although tests revealed no significant differences (P=0...
February 28, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28243770/sudden-aortic-death-proposal-for-a-comprehensive-diagnostic-approach-in-forensic-and-in-clinical-pathology-practice
#10
Hans H de Boer, Fabrice Dedouit, Nina Chappex, Allard C van der Wal, Katarzyna Michaud
BACKGROUNDS: Aortic rupture or dissection as immediate cause of sudden death is encountered in forensic and clinical autopsy practice. Despite a common denominator of 'sudden aortic death' (SAD), we expect that in both settings the diagnostic workup, being either primarily legal or primarily disease related, differs substantially, which may affect the eventual diagnoses. METHODS: We retrospectively reviewed case records of deceased persons who fitted a diagnosis of SAD in the continuous autopsy cohorts in a forensic (Suisse) and a clinical setting (The Netherlands)...
February 27, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28236029/how-is-post-mortem-microbiology-appraised-by-pathologists-results-from-a-practice-survey-conducted-by-esgfor
#11
V Saegeman, M C Cohen, J Alberola, N Ziyade, C Farina, G Cornaglia, A Fernández-Rodríguez
Post-mortem microbiology (PMM) is an important tool in forensic pathology, assisting to determine the cause and manner of death. However, there is a lack of standardisation of PMM sampling. In order to get a better insight into the methods used, the available technical options and developmental needs, ESCMID Study Group for Forensic and Postmortem Microbiology (ESGFOR) members designed a survey aimed at pathologists regarding common practices of PMM in clinical and forensic autopsies. Multiple choice questions were developed based on Cumulative Techniques and Procedures in Clinical Microbiology (Cumitech)...
February 24, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28176637/personalized-medicine-applied-to-forensic-sciences-new-advances-and-perspectives-for-a-tailored-forensic-approach
#12
Alessandro Santurro, Anna Maria Vullo, Marina Borro, Giovanna Gentile, Raffaele La Russa, Maurizio Simmaco, Paola Frati, Vittorio Fineschi
Personalized medicine (PM), included in P5 medicine (Personalized, Predictive, Preventive, Participative and Precision medicine) is an innovative approach to the patient, emerging from the need to tailor and to fit the profile of each individual. PM promises to dramatically impact also on forensic sciences and justice system in ways we are only beginning to understand. The application of omics (genomic, transcriptomics, epigenetics/imprintomics, proteomic and metabolomics) is ever more fundamental in the so called "molecular autopsy"...
February 7, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28122325/demographic-clinical-and-pathological-features-of-sudden-deaths-due-to-myocarditis-results-from-a-state-wide-population-based-autopsy-study
#13
Liliang Li, Yang Zhang, Allen Burke, Aimin Xue, Ziqin Zhao, David Fowler, Yiwen Shen, Ling Li
Causes of sudden cardiac deaths have been widely reported with limited data focused specifically on myocarditis. A retrospective review of cases from the Office of the Chief Medical Examiner (OCME), State of Maryland yielded a total of 103 sudden unexpected deaths (SUDs) due to myocarditis (0.17% of all SUDs and 0.70% of autopsied SUDs) from 2005 through 2014. Most deaths occurred in patients <30 years of age with a male:female ratio 1.3:1. Of the 103 cases, 45 (43.7%) patients were witnessed collapsed. Four deaths occurred during exertion, such as exercising at the gym or performing heavy physical work, and 2 deaths were associated with emotional stress...
January 3, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28064358/incipient-progressive-supranuclear-palsy-is-more-common-than-expected-and-may-comprise-clinicopathological-subtypes-a-forensic-autopsy-series
#14
Koji Yoshida, Yukiko Hata, Koshi Kinoshita, Shutaro Takashima, Kortaro Tanaka, Naoki Nishida
We investigated 998 serial Japanese forensic autopsy cases (0-101 years old, mean age 61.7 ± 21.9), with no case selection, using immunohistochemistry to detect cases with progressive supranuclear palsy (PSP). Twenty-nine cases (mean age 82.3 ± 7.2 years, 11 males, 18 females) fulfilled the National Institute of Neuronal Disorders and Stroke (NINDS)-PSP pathological criteria (2.9% of all cases, 4.6% of cases over 60). All had neuronal and glial inclusions in the basal ganglia and brainstem. However, 13 cases had low tau pathology and were categorized as atypical PSP...
May 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28056376/technical-note-a-preliminary-comparative-study-between-classical-and-interventional-radiological-approaches-for-multi-phase-post-mortem-ct-angiography
#15
Fatima-Zohra Mokrane, Frederic Savall, Laurent Dercle, Eric Crubezy, Norbert Telmon, Hervé Rousseau, Fabrice Dedouit
PURPOSE: Multi-phase post-mortem computed tomography angiography (MPMCTA) is a new diagnostic tool, used in forensic pathology. On the one hand, this technique allows a better and direct visualization of vascular and solid organ lesions. On the other hand, the invasiveness of the procedure-which requires surgical denudation (inguinal and/or cervical) and the insertion of surgical cannulas-leads to many relatives refusing scientific autopsies. Our hypothesis states that a minimally-invasive procedure combining interventional radiological techniques with MPMCTA (replacement of surgical cannulas by radiological catheters) will improve the approval rate of scientific autopsies by families...
December 19, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27994303/accessory-spleen-in-the-splenic-hilum-a-cadaveric-study-with-clinical-significance
#16
Shabnam Mohammadi, Arya Hedjazi, Maryam Sajjadian, Naser Ghrobi, Maliheh Dadgar Moghadam, Maryam Mohammadi
AIM: An accessory spleen is an additional tissue of the spleen that may be found near the spleen. It is a congenital anomaly of the spleen that its incidence has been reported 10-30% of the population. Hence, the objective of this study was evaluation the incidence of accessory spleen in Iranian cadavers. METHOD: Sixty hundred and ninety three spleens (541 males, 152 females) were excised from cadavers in the dissection hall of Mashhad Forensic Medicine Organization cadavers...
October 2016: Medical Archives
https://www.readbyqxmd.com/read/27933413/investigation-on-genetic-thrombophilic-factors-in-ffpe-autopsy-tissue-from-subjects-who-died-from-pulmonary-embolism
#17
Francesco Brandimarti, Federica Alessandrini, Mauro Pesaresi, Chiara Catalani, Letizia De Angelis, Roberta Galeazzi, Simona Giovagnetti, Rosaria Gesuita, Elisa Righi, Raffaele Giorgetti, Adriano Tagliabracci
Venous thromboembolism (VTE) is a multifactorial disease determined by a combination of inherited and acquired factors. Inherited factors include mutations in the genes coding for coagulation factors, some of which seem to exert a differential influence on the risk of developing deep vein thrombosis (DVT) and pulmonary embolism (PE). In post-mortem studies of subjects who have died from pulmonary embolism (PE), the analysis of the factors that may have augmented the VTE risk is often limited to acquired factors...
March 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27913880/forensic-3d-documentation-of-skin-injuries
#18
Chiara Villa
An accurate and precise documentation of injuries is fundamental in a forensic pathological context. Photographs and manual measurements are taken of all injuries during autopsies, but ordinary photography projects a 3D wound on a 2D space. Using technologies such as photogrammetry, it is possible to create 3D detailed, to-scale, true-color documentation of skin injuries from 2D pictures. A comparison between the measurements of 165 lesions taken during autopsies and on photogrammetrically processed pictures was performed...
December 2, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27766573/diagnosis-of-myocardial-ischemia-combining-multiphase-postmortem-ct-angiography-histology-and-postmortem-biochemistry
#19
Jessica Vanhaebost, Kewin Ducrot, Sébastien de Froidmont, Maria Pia Scarpelli, Coraline Egger, Pia Baumann, Gregory Schmit, Silke Grabherr, Cristian Palmiere
PURPOSE: The aim of this study was to assess whether the identification of pathological myocardial enhancement at multiphase postmortem computed tomography angiography was correlated with increased levels of troponin T and I in postmortem serum from femoral blood as well as morphological findings of myocardial ischemia. We further aimed to investigate whether autopsy cases characterized by increased troponin T and I concentrations as well as morphological findings of myocardial ischemia were also characterized by pathological myocardial enhancement at multiphase postmortem computed tomography angiography...
February 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/27763584/-forensic-medical-characteristic-of-the-causes-behind-sudden-death-in-the-young-subjects
#20
Yu I Pigolkin, M A Shilova, E M Kil'dyushov, Eksp Gal'chikov
The objective of the present study was to analyze the causes of sudden death in the general population and in the fraction of the young subjects (below 39 years of age). The results of the original retrospective study were obtained in the course of forensic medical autopsies of the subjects aged below 39 years that had been carried out during a period of 10 years. It was shown that one of the causes behind sudden death among the young subjects is cardiovascular disorders associated with the pre-existing pathological condition in the form of connective tissue dysplasia...
2016: Sudebno-meditsinskaia Ekspertiza
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