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Nucleotide supplementation

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https://www.readbyqxmd.com/read/29669884/iron-acquisition-and-siderophore-release-by-carbapenem-resistant-sequence-type-258-klebsiella-pneumoniae
#1
Victoria I Holden, Meredith S Wright, Sébastien Houle, Abigail Collingwood, Charles M Dozois, Mark D Adams, Michael A Bachman
Klebsiella pneumoniae is rapidly acquiring resistance to all known antibiotics, including carbapenems. Multilocus sequence type ST258 (sequence type 258), carrying a gene encoding the K. pneumoniae carbapenemase ( bla KPC ) on a transmissible plasmid, is the most prevalent carbapenem-resistant Enterobacteriaceae (CRE) in the United States and has disseminated worldwide. Previously, whole-genome sequencing identified core genome single nucleotide variants that divide ST258 into two distinct clades, ST258a and ST258b...
April 25, 2018: MSphere
https://www.readbyqxmd.com/read/29666206/taurine-supplementation-for-prevention-of-stroke-like-episodes-in-melas-a-multicentre-open-label-52-week-phase-iii-trial
#2
Yutaka Ohsawa, Hiroki Hagiwara, Shin-Ichiro Nishimatsu, Akihiro Hirakawa, Naomi Kamimura, Hideaki Ohtsubo, Yuta Fukai, Tatsufumi Murakami, Yasutoshi Koga, Yu-Ichi Goto, Shigeo Ohta, Yoshihide Sunada
OBJECTIVE: The aim of this study was to evaluate the efficacy and safety of high-dose taurine supplementation for prevention of stroke-like episodes of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes), a rare genetic disorder caused by point mutations in the mitochondrial DNA that lead to a taurine modification defect at the first anticodon nucleotide of mitochondrial tRNALeu(UUR) , resulting in failure to decode codons accurately. METHODS: After the nationwide survey of MELAS, we conducted a multicentre, open-label, phase III trial in which 10 patients with recurrent stroke-like episodes received high-dose taurine (9 g or 12 g per day) for 52 weeks...
April 17, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29660814/effects-of-cd36-genotype-on-oral-perception-of-oleic-acid-supplemented-safflower-oil-emulsions-in-two-ethnic-groups-a-preliminary-study
#3
Brenda Burgess, Melania Melis, Katelyn Scoular, Michael Driver, Karen M Schaich, Kathleen L Keller, Iole Tomassini Barbarossa, Beverly J Tepper
Previous studies demonstrate humans can detect fatty acids via specialized sensors on the tongue, such as the CD36 receptor. Genetic variation at the common single nucleotide polymorphism rs1761667 of CD36 has been shown to differentially impact the perception of fatty acids, but comparative data among different ethnic groups are lacking. In a small cohort of Caucasian and East Asian young adults, we investigated if: (1) participants could detect oleic acid (C18:1) added to safflower oil emulsions at a constant ratio of 3% (w/v); (2) supplementation of oleic acid to safflower oil emulsions enhanced perception of fattiness and creaminess; and (3) variation at rs1761667 influenced oleic acid detection and fat taste perception...
April 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29616323/effects-of-dietary-nucleotide-supplementation-on-growth-in-infants-a-meta-analysis-of-randomized-controlled-trials
#4
Lanfang Wang, Shu Mu, Xiaoyan Xu, Zhexi Shi, Li Shen
PURPOSE: Dietary nucleotides are thought to be conditionally essential nutrients in infancy. However, studies have reported inconsistent findings regarding the association between nucleotide supplementation and infant physical growth. We conducted this meta-analysis to examine the efficacy of nucleotide supplementation of infant formula in promoting early infant growth. METHODS: Randomized controlled trials that evaluated the association between nucleotide supplementation and infant growth through June 2017 were included...
April 3, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29609868/genetic-variants-in-selenoprotein-genes-modulate-biomarkers-of-selenium-status-in-response-to-brazil-nut-supplementation-the-su-bra-nut-study
#5
Janaina L S Donadio, Marcelo M Rogero, Elvira M Guerra-Shinohara, Fernando Barbosa, Charles Desmarchelier, Patrick Borel, Alan A Sneddon, John E Hesketh, Silvia M F Cozzolino
BACKGROUND: The beneficial effects of selenium (Se) to human health are exerted by selenoproteins, which can be quantified in blood and used as biomarkers of Se status. Different responses of Se biomarkers after supplementation with selenomethionine and sodium selenite have been observed and some of them could be due to genetic polymorphisms, mainly single nucleotide polymorphisms (SNPs). Brazil nuts are known to be the richest natural source of Se. OBJECTIVE: Investigate how genetic variations in selenoprotein genes modulate biomarkers of Se status in response to Brazil nut supplementation...
March 23, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29593721/vitamin-d-in-human-immunodeficiency-virus-infection-influence-on-immunity-and-disease
#6
REVIEW
María Ángeles Jiménez-Sousa, Isidoro Martínez, Luz María Medrano, Amanda Fernández-Rodríguez, Salvador Resino
People living with human immunodeficiency virus (HIV) infection typically have hypovitaminosis D, which is linked to a large number of pathologies, including immune disorders and infectious diseases. Vitamin D (VitD) is a key regulator of host defense against infections by activating genes and pathways that enhance innate and adaptive immunity. VitD mediates its biological effects by binding to the Vitamin D receptor (VDR), and activating and regulating multiple cellular pathways. Single nucleotide polymorphisms in genes from those pathways have been associated with protection from HIV-1 infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29590619/serine-availability-influences-mitochondrial-dynamics-and-function-through-lipid-metabolism
#7
Xia Gao, Katie Lee, Michael A Reid, Sydney M Sanderson, Chuping Qiu, Siqi Li, Juan Liu, Jason W Locasale
Cell proliferation can be dependent on the non-essential amino acid serine, and dietary restriction of serine inhibits tumor growth, but the underlying mechanisms remain incompletely understood. Using a metabolomics approach, we found that serine deprivation most predominantly impacts cellular acylcarnitine levels, a signature of altered mitochondrial function. Fuel utilization from fatty acid, glucose, and glutamine is affected by serine deprivation, as are mitochondrial morphological dynamics leading to increased fragmentation...
March 27, 2018: Cell Reports
https://www.readbyqxmd.com/read/29569543/effect-of-nutritional-supplement-on-bone-marrow-derived-mesenchymal-stem-cells-from-aplastic-anaemia
#8
Shihua Luo, Yinghai Chen, Lifen Zhao, Xia Qi, Xiaoyan Miao, Huimin Zhou, Li Jia
Aplastic anaemia (AA) is characterised by pancytopenia resulting from a marked reduction in haemopoietic stem cells (HSC). The regulation of haemopoiesis depends on the interaction between HSC and various cells of the bone marrow (BM) microenvironment, including BM-derived mesenchymal stromal cells (BMSC). The purpose of this study was to analyse the biological effect of nutritional supplement (NS), a dietary supplement consisting of thirty-six compounds: amino acids, nucleotides, vitamins and micronutrients on the BMSC of AA rats...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29555969/nucleotide-mediated-spdef-modulates-tff3-mediated-wound-healing-and-intestinal-barrier-function-during-the-weaning-process
#9
Sang In Lee, In Ho Kim
Most alterations during weaning involve physiological changes in intestinal structure and function. Here, we evaluated the molecular mechanisms regulating the effects of nucleotides on weaning. Nucleotide treatment induced Trefoil factor 3 (TFF3) expression and IPEC-J2 cell growth and reduced wound width. Treatment with nucleosides and TFF3 in lipopolysaccharide-challenged IPEC-J2 cells increased intestinal transepithelial electrical resistance and decreased intestinal permeability. Additionally, nucleosides improved intestinal barrier function through induction of TFF3-mediated phosphatidylinositol 3-kinase/Akt, extracellular signal-regulated kinase 1/2, p38, and Janus kinase/signal transducer and activator of transcription signaling pathways...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29554241/glucose-is-preferentially-utilized-for-biomass-synthesis-in-pressure-overloaded-hearts-evidence-from-fatty-acid-binding-protein-4-and-5-knockout-mice
#10
Yogi Umbarawan, Mas Rizky A A Syamsunarno, Norimichi Koitabashi, Aiko Yamaguchi, Hirofumi Hanaoka, Takako Hishiki, Yoshiko Nagahata-Naito, Hideru Obinata, Motoaki Sano, Hiroaki Sunaga, Hiroki Matsui, Yoshito Tsushima, Makoto Suematsu, Masahiko Kurabayashi, Tatsuya Iso
Aims: The metabolism of the failing heart is characterized by an increase in glucose uptake with reduced fatty acid (FA) oxidation. We previously found that the genetic deletion of fatty acid binding protein-4 and -5 (DKO) induces an increased myocardial reliance on glucose with decreased FA uptake in mice. However, whether this fuel switch confers functional benefit during the hypertrophic response remains open to debate. To address this question, we investigated the contractile function and metabolic profile of DKO hearts subjected to pressure overload...
March 15, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29510469/flaxseed-oil-attenuates-intestinal-damage-and-inflammation-by-regulating-necroptosis-and-tlr4-nod-signaling-pathways-following-lipopolysaccharide-challenge-in-a-piglet-model
#11
Huiling Zhu, Haibo Wang, Shuhui Wang, Zhixiao Tu, Lin Zhang, Xiuying Wang, Yongqing Hou, Chunwei Wang, Jie Chen, Yulan Liu
SCOPE: Flaxseed oil is a rich source of α-linolenic acid (ALA), which is the precursor of the long-chain n-3 polyunsaturated fatty acids (PUFAs) including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). This study investigated the protective effect of flaxseed oil against intestinal injury induced by lipopolysaccharide (LPS). MATERIALS AND RESULTS: Twenty-four weaned pigs were used in a 2 × 2 factorial experiment with dietary treatment (5% corn oil vs...
March 6, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29508680/medium-chain-tag-improve-intestinal-integrity-by-suppressing-toll-like-receptor-4-nucleotide-binding-oligomerisation-domain-proteins-and-necroptosis-signalling-in-weanling-piglets-challenged-with-lipopolysaccharide
#12
Xiao Xu, Shaokui Chen, Haibo Wang, Zhixiao Tu, Shuhui Wang, Xiuying Wang, Huiling Zhu, Chunwei Wang, Jiadong Zhu, Yulan Liu
This study was conducted to evaluate whether medium-chain TAG (MCT) could alleviate Escherichia coli lipopolysaccharide (LPS)-induced intestinal injury by regulating intestinal epithelial inflammatory response, as well as necroptosis. A total of twenty-four weanling piglets were randomly allotted to one of four treatments in a 2×2 factorial arrangement including diet type (5 % maize oil v. 4 % MCT+1 % maize oil) and immune stress (saline v. E. coli LPS). The piglets were fed diets containing maize oil or MCT for 21 d...
March 6, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29508031/neisseria-zalophi-sp-nov-isolated-from-oral-cavity-of-california-sea-lions-zalophus-californianus
#13
Dmitriy V Volokhov, Megan Amselle, Sonya Bodeis-Jones, Pierluigi Delmonte, Shuping Zhang, Maureen K Davidson, Frances M Gulland, Vladimir E Chizhikov
Three independent strains of Neisseria sp. were isolated from the oral cavity of California sea lions (Zalophus californianus) that were admitted to The Marine Mammal Center facilities in California, USA. The strains were isolated from oral swabs by cultivation on Trypticase Soy agar with 5% sheep blood under aerobic conditions. The 16S rRNA gene sequence of these three strains shared 99% similarity, but demonstrated only 97-98% nucleotide similarity to the phylogenetically closest relatives such as N. canis, N...
March 5, 2018: Archives of Microbiology
https://www.readbyqxmd.com/read/29495256/identification-of-uncultured-bacterial-species-from-firmicutes-bacteroidetes-and-candidatus-saccharibacteria-as-candidate-cellulose-utilizers-from-the-rumen-of-beef-cows
#14
Lee James Opdahl, Michael G Gonda, Benoit St-Pierre
The ability of ruminants to utilize cellulosic biomass is a result of the metabolic activities of symbiotic microbial communities that reside in the rumen. To gain further insight into this complex microbial ecosystem, a selection-based batch culturing approach was used to identify candidate cellulose-utilizing bacterial consortia. Prior to culturing with cellulose, rumen contents sampled from three beef cows maintained on a forage diet shared 252 Operational Taxonomic Units (OTUs), accounting for 41.6-50.0% of bacterial 16S rRNA gene sequences in their respective samples...
February 24, 2018: Microorganisms
https://www.readbyqxmd.com/read/29487501/a-review-of-oxytocin-and-arginine-vasopressin-receptors-and-their-modulation-of-autism-spectrum-disorder
#15
REVIEW
Ilaria Cataldo, Atiqah Azhari, Gianluca Esposito
Oxytocin ( OXT ) and arginine-vasopressin ( AVP ) play a key regulatory part in social and affiliative behaviors; two aspects highly compromised in Autism Spectrum Disorder (ASD). Furthermore, variants in the adjacent oxytocin-vasopressin gene regions have been found to be associated with ASD diagnosis and endophenotypes. This review focuses mainly on common OXTr single nucleotide polymorphisms (SNPs), AVPR1a microsatellites and AVPR1b polymorphisms in relation to the development of autism. Although these genes did not surface in genome-wide association studies, evidence supports the hypothesis that these receptors and their polymorphisms are widely involved in the regulation of social behavior, and in modulating neural and physiological pathways contributing to the etiology of ASD...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29486129/pyrimidine-nucleotide-synthesis-in-the-emerging-pathogen-i-pseudomonas-monteilii-i
#16
Jayendra Chunduru, Thomas P West
Regulation of pyrimidine biosynthesis by pyrimidines in the emerging, opportunistic human pathogen <i>Pseudomonas monteilii</i> ATCC 700476 was evident. When wild type cells were grown on succinate in the presence of uracil or orotic acid, all five pyrimidine biosynthetic enzyme activities were depressed while three enzyme activities decreased in glucose-grown cells supplemented with uracil or orotic acid compared to unsupplemented cells. Pyrimidine limitation of succinate-grown or glucose-grown pyrimidine auxotrophic cells lacking orotate phosphoribosyltransferase activity resulted in more than a doubling of the pyrimidine biosynthetic enzyme activities relative to their activities in uracil-grown cells...
February 27, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29484537/establishment-of-two-basal-like-breast-cancer-cell-lines-with-extremely-low-tumorigenicity-from-taiwanese-premenopausal-women
#17
Wen-Ling Kuo, Shir-Hwa Ueng, Chun-Hsing Wu, Li-Yu Lee, Yun-Shien Lee, Ming-Chin Yu, Shin-Cheh Chen, Chi-Chang Yu, Chi-Neu Tsai
The research of carcinogenetic mechanisms of breast cancer in different ethnic backgrounds is an interesting field, as clinical features of breast cancers vary among races. High premenopausal incidence is distinctive in East-Asian breast cancer. However, human cell lines derived from Asian primary breast tumor are rare. To provide alternative cell line models with a relevant genetic background, we aimed to establish breast cancer cell lines from Taiwanese patients of Han-Chinese ethnicity. Fresh tissue from mammary tumors were digested into organoids, plated and grown in basal serum-free medium of human mammary epithelial cells (HuMEC) with supplements...
February 26, 2018: Human Cell
https://www.readbyqxmd.com/read/29471827/nuclear-functions-of-mammalian-micrornas-in-gene-regulation-immunity-and-cancer
#18
REVIEW
Hongyu Liu, Cheng Lei, Qin He, Zou Pan, Desheng Xiao, Yongguang Tao
MicroRNAs (miRNAs) are endogenous non-coding RNAs that contain approximately 22 nucleotides. They serve as key regulators in various biological processes and their dysregulation is implicated in many diseases including cancer and autoimmune disorders. It has been well established that the maturation of miRNAs occurs in the cytoplasm and miRNAs exert post-transcriptional gene silencing (PTGS) via RNA-induced silencing complex (RISC) pathway in the cytoplasm. However, numerous studies reaffirm the existence of mature miRNA in the nucleus, and nucleus-cytoplasm transport mechanism has also been illustrated...
February 22, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29467015/prevention-of-disease-progression-in-leishmania-infantum-infected-dogs-with-dietary-nucleotides-and-active-hexose-correlated-compound
#19
Sergi Segarra, Guadalupe Miró, Ana Montoya, Luis Pardo-Marín, Joan Teichenné, Lluís Ferrer, José Joaquín Cerón
BACKGROUND: The prevalence of Leishmania infantum infection in clinically healthy dogs can be several times higher than that of clinical disease in endemic areas. Although treatment is not recommended in dogs with subclinical infection, these animals should be managed to prevent disease progression and parasite transmission to human beings or to other dogs. Dietary nucleotides and active hexose correlated compound (AHCC) have been shown to modulate the immune response. A recent study in dogs with clinical leishmaniosis receiving an initial 28-day course of methylglucamine antimoniate showed that six-month administration of a dietary supplement containing nucleotides plus AHCC achieves similar efficacy to allopurinol...
February 21, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29466287/comparison-of-inhibitory-capacities-of-6-8-and-10-gingerols-shogaols-on-the-canonical-nlrp3-inflammasome-mediated-il-1%C3%AE-secretion
#20
Su-Chen Ho, Yi-Huang Chang
Endogenous noninfectious substances that mediate the nucleotide oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation and interleukin (IL)-1β secretion causes inappropriate sterile inflammation and is implicated in the pathogenesis of several chronic diseases, such as type 2 diabetes mellitus, gout, atherosclerosis and Alzheimer's disease. Consequently, dietary phytochemicals exhibiting capacities to suppress canonical NLRP3 inflammasome-mediated IL-1β secretion can be a reliable supplement to prevent such diseases...
February 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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