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https://www.readbyqxmd.com/read/29786110/multi%C3%A2-layered-prevention-and-treatment-of-chronic-inflammation-organ-fibrosis-and-cancer-associated-with-canonical-wnt-%C3%AE-%C3%A2-catenin-signaling-activation-review
#1
Masaru Katoh
β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins), transmembrane‑type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHERF1/EBP50) and epigenetic or transcriptional regulators (BCL9, BCL9L, CREBBP/CBP, EP300/p300, FOXM1, MED12, SMARCA4/BRG1 and TCF/LEF). Gain‑of‑function CTTNB1 mutations are detected in bladder cancer, colorectal cancer, gastric cancer, liver cancer, lung cancer, pancreatic cancer, prostate cancer and uterine cancer, whereas loss‑of‑function CTNNB1 mutations are also detected in human cancer...
May 17, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29784129/the-non-psychoactive-phytocannabinoid-cannabidiol-cbd-attenuates-pro-inflammatory-mediators-t-cell-infiltration-and-thermal-sensitivity-following-spinal-cord-injury-in-mice
#2
Hongbo Li, Weimin Kong, Christina R Chambers, Daohai Yu, Doina Ganea, Ronald F Tuma, Sara Jane Ward
We evaluated the effects of the non-psychoactive cannabinoid cannabidiol (CBD) on the inflammatory response and recovery of function following spinal cord injury (SCI). Female C57Bl/6 mice were exposed to spinal cord contusion injury (T9-10) and received vehicle or CBD (1.5 mg/kg IP) injections for 10 weeks following injury. The effect of SCI and CBD treatment on inflammation was assessed via microarray, qRT-PCR and flow cytometry. Locomotor and bladder function and changes in thermal and mechanical hind paw sensitivity were also evaluated...
March 8, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29783036/retrospective-study-on-the-management-and-follow-up-of-18-patients-with-a-mid-urethral-sling-penetrating-the-urethra-or-bladder
#3
Edouard Goujon, Adélaide Jarniat, Florian Bardet, Lise Bergogne, Emmanuel Delorme
INTRODUCTION: The mid-urethral sling (MUS) procedure is the gold-standard for the surgical treatment of stress urinary incontinence (SUI). Urethro-vesical sling exposure is one of the most serious complications of this procedure. We describe the treatment and follow-up of 18 patients with bladder or urethral sling exposure. PATIENTS AND METHODS: This single-center, retrospective study assessed the diagnosis and management of MUS penetrating the lower urinary tract in 18 women...
May 18, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29781566/the-5-ht7-receptor-is-up-regulated-in-onuf-s-nucleus-in-rats-with-chronic-spinal-cord-injury
#4
Jianshu Ni, Nailong Cao, Xiaohu Wang, Changsheng Zhan, Jiemin Si, Baojun Gu, Karl-Erik Andersson
OBJECTIVES: To examine the effect of intrathecal 5-HT7 agonist administration on voiding function in urethane-anesthetized rat, and the change of 5-HT7 receptor expression in lumbosacral cord Onuf's nucleus after SCI. MATERIALS AND METHODS: Thirty-two female Sprague-Dawley (SD) rats were divided into spinally intact (SI) group and SCI group (n=16 each). Eight weeks after transection, half of the rats underwent continuous cystometry under urethane anesthetization, and the 5-HT7 selective agonist LP44 was given intrathecally...
May 21, 2018: BJU International
https://www.readbyqxmd.com/read/29780779/sonographic-evaluation-of-bladder-wall-thickness-in-women-with-lower-urinary-tract-dysfunction
#5
Un Ju Shin, Jihye Koh, Jiwon Song, Soyun Park, Eun Joo Park, Chung-Hoon Kim, Sung Hoon Kim, Byung Moon Kang, Hee Dong Chae
Objective: To investigate the correlation between bladder wall thickness (BWT) measured by ultrasonography and lower urinary tract dysfunction (LUTD) in patients with lower urinary tract symptoms (LUTS). Methods: Forty-eight women with LUTS who underwent urodynamic study and BWT by ultrasonography as outpatients were studied. We assessed LUTS during a medical examination by interview. The thinnest part of the bladder wall was measured by a transabdominal ultrasonography...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29777787/patency-and-incontinence-rates-after-robotic-bladder-neck-reconstruction-for-vesicourethral-anastomotic-stenosis-and-recalcitrant-bladder-neck-contractures-the-turns-experience
#6
Eric J Kirshenbaum, Lee C Zhao, Jeremy B Myers, Sean P Elliott, Alex J Vanni, Nima Baradaran, Bradley A Erickson, Jill C Buckley, Bryan B Voelzke, Michael A Granieri, Stephen J Summers, Benjamin N Breyer, Atreya Dash, Aaron Weinberg, Nejd F Alsikafi
OBJECTIVE: To review a robotic approach to recalcitrant bladder neck obstruction and assess success and incontinence rates. METHODS: Patients with a recalcitrant bladder neck contracture or vesicourethral anastomotic stenosis who underwent robotic bladder neck reconstruction (RBNR) were identified. We reviewed patient demographics, medical history, etiology, previous endoscopic management, cystoscopic and symptomatic outcomes, urinary continence and complications...
May 16, 2018: Urology
https://www.readbyqxmd.com/read/29777786/photoselective-vaporisation-of-the-bladder-for-the-management-of-radiation-cystitis-technique-and-initial-outcomes
#7
Claire Pascoe, Daniel Christidis, Todd Manning, Benjamin W Lamb, Declan G Murphy, Nathan Lawrentschuk
Objective To describe our technique utilising photoselective vaporisation of the bladder (PVB) for the management of haemorrhagic cystitis and initial results of 12 patients. Materials and Method An audit of theatre records of a single surgeon was performed to identify patients who had undergone PVB for management of radiation-cystitis. TECHNIQUE: Rigid cystoscopy was performed. Ureteric catheters were placed and active bleeding sites targeted to optimise vision. Ablation was commenced using the vaporize function...
May 16, 2018: Urology
https://www.readbyqxmd.com/read/29777585/potential-vascular-mechanisms-in-an-ex-vivo-functional-pig-bladder-model
#8
Uzoma A Anele, Paul H Ratz, Andrew F Colhoun, Sydney Roberts, Ryan Musselman, Randy A Vince, John E Speich, Adam P Klausner
AIMS: Chronic ischemia is a recognized factor in the pathophysiology of underactive bladder (UAB). Although relative ischemia (ie, low blood flow) is known to occur during filling, little is known regarding the pathophysiology that leads to UAB. Therefore, we developed an ex vivo functional porcine model to investigate the role of transient ischemia and whether autoregulation, a mechanism that maintains tissue oxygenation in certain vital organs, also exists in the bladder. METHODS: Using bladders from slaughtered pigs, we prepared an isolated perfused model where we studied the effects of bladder perfusion flow rate on perfusion pressure and tissue oxygenation during the filling phase...
May 19, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29776868/hemorrhagic-cystitis-after-hematopoietic-stem-cell-transplantation-a-challenge-for-the-pediatric-urologist
#9
REVIEW
Romy Gander, Marino Asensio, Gabriela Guillén, Gloria Fatou Royo, Andrea Bolaños, Mercedes Pérez, Cristina Diaz-De-Heredia, Maribel Benitez, Manuel López
OBJECTIVE: Hemorrhagic cystitis (HC) is a serious event that can occur after hematopoietic stem cell transplantation (HSCT). Treatment goals are primarily to preserve life, and then the functionality of the bladder. There is no standard therapeutic approach for HC. Described treatment options provide low success rates and are related to potential life-threatening side effects. The aim of this study was to describe our experience in treatment of HC following HSCT. PATIENTS AND METHODS: This was a retrospective study of patients with HC treated at our institution between January 2010 and October 2016...
April 20, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29774817/bladder-reconstruction-with-bowel-robot-assisted-laparoscopic-ileocystoplasty-with-mitrofanoff-appendicovesicostomy-in-pediatric-patients
#10
Nimrod S Barashi, Maria Veronica Rodriguez, Vignesh T Packiam, Mohan S Gundeti
Neurogenic bladder occur as a consequence of several conditions, most commonly posterior urethral valves syndrome, spina bifida, tethered cord, sacral agenesis, and Arnold-Chiari malformation. It is characterized by diminished bladder capacity and/or reduced compliance, associated with high-pressure voiding that can lead to deterioration of renal function if left untreated. When medical management fails, bladder reconstruction with bowel (aumentation ileocystoplasty) becomes the treatment of choice for these patients...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29773994/biological-roles-of-aberrantly-expressed-glycosphingolipids-and-related-enzymes-in-human-cancer-development-and-progression
#11
REVIEW
Dinghao Zhuo, Xiang Li, Feng Guan
Glycosphingolipids (GSLs), which consist of a hydrophobic ceramide backbone and a hydrophilic carbohydrate residue, are an important type of glycolipid expressed in surface membranes of all animal cells. GSLs play essential roles in maintenance of plasma membrane stability, in regulation of numerous cellular processes (including adhesion, proliferation, apoptosis, and recognition), and in modulation of signal transduction pathways. GSLs have traditionally been classified as ganglio-series, lacto-series, or globo-series on the basis of their diverse types of oligosaccharide chains...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29772880/detection-of-spatial-aggregation-of-cases-of-cancer-from-data-on-patients-and-health-centres-contained-in-the-minimum-basic-data-set
#12
Pablo Fernández-Navarro, Jose-Miguel Sanz-Anquela, Angel Sánchez Pinilla, Rosario Arenas Mayorga, Carmen Salido-Campos, Gonzalo López-Abente
The feasibility of the Minimum Basic Data Set (MBDS) as a tool in cancer research was explored monitoring its incidence through the detection of spatial clusters. Case-control studies based on MBDS and marked point process were carried out with the focus on the residence of patients from the Prince of Asturias University Hospital in Alcalá de Henares (Madrid, Spain). Patients older than 39 years with diagnoses of stomach, colorectal, lung, breast, prostate, bladder and kidney cancer, melanoma and haematological tumours were selected...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29772347/location-dependent-correlation-between-tissue-structure-and-the-mechanical-behaviour-of-the-urinary-bladder
#13
Enrique Morales-Orcajo, Tobias Siebert, Markus Böl
The mechanical properties of the urinary bladder wall are important to understand its filling-voiding cycle in health and disease. However, much remains unknown about its mechanical properties, especially regarding regional heterogeneities and wall microstructure. The present study aimed to assess the regional differences in the mechanical properties and microstructure of the urinary bladder wall. Ninety (n=90) samples of porcine urinary bladder wall (ten samples from nine different locations) were mechanically and histologically analysed...
May 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29772077/a-feature-alignment-score-for-online-cone-beam-ct-based-image-guided-radiotherapy-for-prostate-cancer
#14
Catriona Hargrave, Timothy Deegan, Michael Poulsen, Tomasz Bednarz, Fiona Harden, Kerrie Mengersen
PURPOSE: To develop a method for scoring online cone-beam CT (CBCT)-to-planning CT image feature alignment to inform prostate image-guided radiotherapy (IGRT) decision-making. The feasibility of incorporating volume variation metric thresholds, predictive of delivering planned dose into weighted functions, was investigated. METHODS: Radiation therapists and radiation oncologists participated in workshops where they reviewed prostate CBCT-IGRT case examples and completed a paper-based survey of image feature matching practices...
May 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29771898/symptoms-of-bowel-dysfunction-and-their-management-after-spinal-cord-injury-in-a-new-zealand-centre
#15
Edwin P Arnold, Giovanni Losco, Sharon English, Frank Frizelle, Angelo Anthony
AIM: To document the symptoms of bowel dysfunction, and how the bowels are managed, in a cohort of patients following a spinal cord injury. To relate these to the level of the spinal injury and to examine the relationship between bowel symptoms and bladder dysfunction. METHOD: Participants were identified from the discharge data from the Burwood Spinal Unit, one of two national Spinal Units in New Zealand, in two two-year sets from 1-3 years post-injury and from 20-21 years post-injury...
May 18, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29764556/-extra-longtime-continuous-chest-compression-to-rescue-cardiopulmonary-arrest-a-case-report-and-the-literature-review
#16
Yan Zhang, Tianxue Yue, Kexin Sun, Jiang Wang, Ruiwu Zhu
The new cardiopulmonary resuscitation (CPR) guideline emphasize the importance of chest compression, which was considered as the first step to CPR. The duration for CPR is usually limited to 30 minutes. With the development of new technology and evidence-based medicine, the success of extra longtime CPR has become possible, which is of great significance to some patients with cardiac arrest (CA), but the time limit has not been determined. On February 23rd in 2016, a 76-year-old female patient with respiratory and cardiac arrest who was on the third day after transurethral resection of bladder tumor (TUR-BT) was admitted to the intensive care unit of the General Hospital of Fushun Mining Bureau...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29759730/citrate-chemistry-and-biology-for-biomaterials-design
#17
Chuying Ma, Ethan Gerhard, Di Lu, Jian Yang
Leveraging the multifunctional nature of citrate in chemistry and inspired by its important role in biological tissues, a class of highly versatile and functional citrate-based materials (CBBs) has been developed via facile and cost-effective polycondensation. CBBs exhibiting tunable mechanical properties and degradation rates, together with excellent biocompatibility and processability, have been successfully applied in vitro and in vivo for applications ranging from soft to hard tissue regeneration, as well as for nanomedicine designs...
May 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29757239/preparation-physicochemical-and-antioxidant-properties-of-acid-and-pepsin-soluble-collagens-from-the-swim-bladders-of-miiuy-croaker-miichthys-miiuy
#18
Wen-Hao Zhao, Chang-Feng Chi, Yu-Qin Zhao, Bin Wang
Collagen is one of the most useful biomaterials and widely applied in functional food and cosmetics. However, some consumers have paid close attention to the safety of mammalian collagens because of the outbreaks of bovine spongiform encephalopathy (BSE), foot-and-mouth disease (FMD), and other prion diseases. Therefore, there is a strong demand for developing alternative sources of collagen, with one promising source being from the process by-products of commercial fisheries. In this report, acid-soluble collagen (ASC-SB) and pepsin-soluble collagen (PSC-SB) from swim bladders of miiuy croaker ( Miichthys miiuy ) were isolated with yields of 1...
May 12, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29755116/health-related-quality-of-life-after-treatment-for-bladder-cancer-in-england
#19
Samantha J Mason, Amy Downing, Penny Wright, Luke Hounsome, Sarah E Bottomley, Jessica Corner, Mike Richards, James W Catto, Adam W Glaser
BACKGROUND: Little is known about quality of life after bladder cancer treatment. This common cancer is managed using treatments that can affect urinary, sexual and bowel function. METHODS: To understand quality of life and inform future care, the Department of Health (England) surveyed adults surviving bladder cancer 1-5 years after diagnosis. Questions related to disease status, co-existing conditions, generic health (EQ-5D), cancer-generic (Social Difficulties Inventory) and cancer-specific outcomes (Functional Assessment of Cancer Therapy-Bladder)...
May 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29753463/de-novo-urologic-malignancies-in-renal-transplant-recipients
#20
H Antunes, E Tavares-da-Silva, R Oliveira, J Carvalho, B Parada, C Bastos, A Figueiredo
BACKGROUND: Immunosuppressed organ transplant patients have an elevated risk of malignancies. The aim of this study was to determine the incidence of urologic malignancies in renal transplant recipients, as well as to evaluate their monitoring, treatment, and outcomes. METHODS: We conducted a retrospective single-center study of 2897 renal transplants between January 1987 and December 2016. Recipients presenting with de novo urologic malignancies were evaluated...
March 10, 2018: Transplantation Proceedings
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