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https://www.readbyqxmd.com/read/29766801/naringenin-and-its-nano-formulations-for-fatty-liver-cellular-modes-of-action-and-clinical-perspective
#1
Mahdi Zobeiri, Tarun Belwal, Fatemeh Parvizi, Rozita Naseri, Mohammad Hosein Farzaei, Seyed Fazel Nabavi, Antoni Sureda, Seyed Mohammad Nabavi
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease mainly caused by high fat diets and sudden feed changes, vitamin and energy deficiency, and inflammatory processes. Fatty liver leads to cirrhosis, hepatocellular carcinoma as well as liver failure. Lifestyle-modifying such as weight loss and healthy diet have an inverse correlation with the risk of fatty liver. The promising effect of a diet rich in vegetables and fruits against fatty liver has been evidenced by several empirical studies focused on flavonoids...
May 14, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29765517/targeting-the-mevalonate-pathway-is-a-novel-therapeutic-approach-to-inhibit-oncogenic-foxm1-transcription-factor-in-human-hepatocellular-carcinoma
#2
Satoshi Ogura, Yuichi Yoshida, Tomohide Kurahashi, Mayumi Egawa, Kunimaro Furuta, Shinichi Kiso, Yoshihiro Kamada, Hayato Hikita, Hidetoshi Eguchi, Hisakazu Ogita, Yuichiro Doki, Masaki Mori, Tomohide Tatsumi, Tetsuo Takehara
Dysregulation of cell metabolism is a hallmark of cancer. The mevalonate pathway in lipid metabolism has been implicated as a potential target of cancer therapy for hepatocellular carcinoma (HCC). The role of the Forkhead Box M1 (FoxM1) transcription factor in HCC development has been well documented, however, its involvement in cancer metabolism of HCC has not been fully determined. Here, we hypothesized that FoxM1 is involved in the mevalonate pathway of cholesterol biosynthesis in HCC. Inhibition of the mevalonate pathway by statins, inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR), resulted in reduced expression of FoxM1 and increased cell death in human hepatoma cells...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29764424/long-non-coding-rna-neat1-modulated-abnormal-lipolysis-via-atgl-drives-hepatocellular-carcinoma-proliferation
#3
Xirui Liu, Yingjian Liang, Ruipeng Song, Guangchao Yang, Jihua Han, Yaliang Lan, Shangha Pan, Mingxi Zhu, Yao Liu, Yan Wang, Fanzheng Meng, Yifeng Cui, Jiabei Wang, Bo Zhang, Xuan Song, Zhaoyang Lu, Tongsen Zheng, Lianxin Liu
BACKGROUND: Abnormal metabolism, including abnormal lipid metabolism, is a hallmark of cancer cells. Some studies have demonstrated that the lipogenic pathway might promote the development of hepatocellular carcinoma (HCC). However, the role of the lipolytic pathway in HCC has not been elucidated. METHODS: We compared levels of adipose triglyceride lipase (ATGL) in human HCC and healthy liver tissues by real time PCR, western blot and immunohistochemistry. We measured diacylglycerol(DAG) and free fatty acid (FFA) levels in HCC cells driven by the NEAT1-ATGL axis and in HCC tissues...
May 15, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29752404/low-density-lipoprotein-receptor-related-protein-1-dysfunction-synergizes-with-dietary-cholesterol-to-accelerate-steatohepatitis-progression
#4
Allyson N Hamlin, Sivaprakasam Chinnarasu, Yinyuan Ding, Xunde Xian, Joachim Herz, Anja Jaeschke, David Y Hui
Reduced low density lipoprotein receptor-related protein-1 (LRP1) expression in the liver is associated with poor prognosis of liver cirrhosis and hepatocellular carcinoma.  Previous studies have shown that hepatic LRP1 deficiency exacerbates palmitate-induced steatosis and toxicity in vitro and also promotes high fat diet-induced hepatic insulin resistance and hepatic steatosis in vivo   The current study examined the impact of liver-specific LRP1 deficiency in disease progression to steatohepatitis.  hLrp1+/+ mice with normal LRP1 expression and hLrp1-/- mice with hepatocyte-specific LRP1 inactivation were fed a high fat-high cholesterol (HFHC) diet for 16 weeks...
May 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29746928/cholesterol-inhibits-hepatocellular-carcinoma-invasion-and-metastasis-by-promoting-cd44-localization-in-lipid-rafts
#5
Zhishi Yang, Wenhao Qin, Yao Chen, Bo Yuan, Xiaoling Song, Bibo Wang, Feng Shen, Jing Fu, Hongyang Wang
Cholesterol plays a vital role in modulating the action of membrane proteins critical to cellular function. The effect of serum cholesterol on the prognosis of hepatocellular carcinoma (HCC) patients remains uncertain. Here, we report that high levels of cholesterol predict good survival and low disease recurrence after surgery. Cholesterol could significantly suppress migration and invasion of HCC cells and restrain metastasis of HCC in mice. High levels of cholesterol promoted CD44 translocation into lipid rafts and attenuated CD44-Ezrin binding, which are crucial for cell migration and cancer metastasis...
May 7, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29744335/detection-of-a-lipid-peroxidation-induced-dna-adduct-across-liver-disease-stages
#6
Heidi Coia, Ning Ma, Aiwu Ruth He, Bhaskar Kallakury, Deborah L Berry, Eva Permaul, Kepher H Makambi, Ying Fu, Fung-Lung Chung
Background: Oxidative stress and chronic inflammation can increase cellular levels of reactive oxygen species and lipid peroxidation (LPO) when associated with the pathogenesis of hepatocellular carcinoma (HCC), which can develop following the progression of steatosis, fibrosis and cirrhosis. Using a monoclonal antibody for cyclic γ-hydroxy-1, N2 -propanodeoxyguanosine (γ-OHPdG), a promutagenic DNA adduct formed endogenously by LPO, we examined its formation across liver disease stages to understand it's potential role in HCC development...
April 2018: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29733540/fabp4-suppresses-proliferation-and-invasion-of-hepatocellular-carcinoma-cells-and-predicts-a-poor-prognosis-for-hepatocellular-carcinoma
#7
Cheng-Qian Zhong, Xiu-Ping Zhang, Ning Ma, Er-Bin Zhang, Jing-Jing Li, Ya-Bo Jiang, Yu-Zhen Gao, Yan-Mei Yuan, Shi-Qian Lan, Dong Xie, Shu-Qun Cheng
Adipocyte fatty acid-binding protein (FABP4) is abundant in macrophage and adipocyte. It is known to be involved in lipid metabolism. The role of FABP4 has been reported in various cancers, such as non-small cell lung cancer, breast cancer, ovarian cancer, and prostatic cancer. However, its role remains unclear in hepatocellular carcinoma (HCC). In our study, we investigated the expression of FABP4 at both mRNA and protein levels, and by examining 175 cases of patients with cancer of the liver tissue microarray, the significance between the expression of FABP4 and clinical characteristics had been discussed...
May 7, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29732980/hcc-specific-protein-network-involving-interactions-of-egfr-with-a-raf-and-transthyretin-experimental-analysis-and-computational-biology-correlates
#8
Maryam Ranjpour, Deepshikha Pande Katare, Saima Wajid, Swatantra Kumar Jain
The network interactions link human disease proteins to regulatory cellular pathways leading to better understanding of protein functions and cellular processes. Revealing the network of signaling pathways in cancer through protein-protein interactions at molecular level enhances our understanding of hepatocellular carcinoma (HCC). A rodent model for study of HCC was developed by administrating N-Nitrosodiethylamine (DEN) and 2-aminoacetylfluorine (2-AAF) to male Wistar rats. Proteomic approaches such as 2D- Electrophoresis, PD-Quest, MALDI-TOF-MS and Western blot analyses have been used to identify, characterize and validate the differentially expressed proteins in HCC-bearing animals vis-a-vis controls...
May 7, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29725020/hcc-derived-exosomes-elicit-hcc-progression-and-recurrence-by-epithelial-mesenchymal-transition-through-mapk-erk-signalling-pathway
#9
Lu Chen, Piao Guo, Yuchao He, Ziye Chen, Liwei Chen, Yi Luo, Lisha Qi, Yuanyuan Liu, Qiang Wu, Yunlong Cui, Feng Fang, Xiaofang Zhang, Tianqiang Song, Hua Guo
Liver cancer is the second most common cause of cancer-related death worldwide. Approximately 70-90% of primary liver cancers are hepatocellular carcinoma (HCC). Currently, HCC patient prognosis is unsatisfactory due to high metastasis and/or post-surgical recurrence rates. Therefore, new therapeutic methods for inhibiting metastasis and recurrence are urgently needed. Exosomes are small lipid-bilayer vesicles that are implicated in tumour development and metastasis. Rab27a, a small GTPase, regulates exosome secretion by mediating multivesicular endosome docking at the plasma membrane...
May 3, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29715085/chemerin-in-a-mouse-model-of-non-alcoholic-steatohepatitis-and-hepatocarcinogenesis
#10
Elisabeth M Haberl, Rebekka Pohl, Lisa Rein-Fischboeck, Susanne Feder, Christopher J Sinal, Christa Buechler
BACKGROUND/AIM: Non-alcoholic steatohepatitis (NASH) is a risk factor for hepatocellular carcinoma (HCC). The adipokine chemerin protects from HCC and is reduced in human HCC. In this study, chemerin expression was analyzed in a murine model of NASH-HCC. MATERIALS AND METHODS: Serum and hepatic chemerin, and ex vivo chemerin receptor activation were monitored in NASH and NASH-HCC in mice fed a low-methionine diet deficient in choline after initiation of tumors by injection of diethylnitrosamine...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29713125/beneficial-effects-of-naringenin-in-liver-diseases-molecular-mechanisms
#11
REVIEW
Erika Hernández-Aquino, Pablo Muriel
Liver diseases are caused by different etiological agents, mainly alcohol consumption, viruses, drug intoxication or malnutrition. Frequently, liver diseases are initiated by oxidative stress and inflammation that lead to the excessive production of extracellular matrix (ECM), followed by a progression to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). It has been reported that some natural products display hepatoprotective properties. Naringenin is a flavonoid with antioxidant, antifibrogenic, anti-inflammatory and anticancer properties that is capable of preventing liver damage caused by different agents...
April 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29702597/corosolic-acid-induces-non-apoptotic-cell-death-through-generation-of-lipid-reactive-oxygen-species-production-in-human-renal-carcinoma-caki-cells
#12
Seon Min Woo, Seung Un Seo, Kyoung-Jin Min, Seung-Soon Im, Ju-Ock Nam, Jong-Soo Chang, Shin Kim, Jong-Wook Park, Taeg Kyu Kwon
Corosolic acid is one of the pentacyclic triterpenoids isolated from Lagerstroemia speciose and has been reported to exhibit anti-cancer and anti-proliferative activities in various cancer cells. In the present study, we investigated the molecular mechanisms of corosolic acid in cancer cell death. Corosolic acid induces a decrease of cell viability and an increase of cell cytotoxicity in human renal carcinoma Caki cells. Corosolic acid-induced cell death is not inhibited by apoptosis inhibitor (z-VAD-fmk, a pan-caspase inhibitor), necroptosis inhibitor (necrostatin-1), or ferroptosis inhibitors (ferrostatin-1 and deferoxamine (DFO))...
April 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29702135/zhiheshouwu-ethanol-extract-induces-intrinsic-apoptosis-and-reduced-unsaturated-fatty-acids-via-srebp1-pathway-in-hepatocellular-carcinoma-cells
#13
Hongliang Li, Longchao Xiang, Nian Yang, Fengjun Cao, Chen Li, Ping Chen, Xuzhi Ruan, Yibin Feng, Nian Zhou, Xuanbin Wang
Hepatocellular carcinoma (HCC) is the major incidence and one of the most life-threatening cancer. How to conquer HCC is a worldwide issue for patients. Zhiheshouwu (Polygoni multiflori Radix Praeparata) is a Chinese medicinal herb exhibiting both lowering lipid and inhibiting cancer cells. However, it remains a matter if its inhibiting cancer cells is related to its lowering lipid. In this study, we investigate the effects of Zhiheshouwu ethanolic extract (HSWE) on apoptosis and the underlying mechanisms in Bel-7402 cells...
April 24, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29679292/preparation-and-optimization-lipid-nanocapsules-to-enhance-the-antitumor-efficacy-of-cisplatin-in-hepatocellular-carcinoma-hepg2-cells
#14
Qingqing Zhai, Hailong Li, Yanlin Song, Ruijiao Wu, Chuanfang Tang, Xiaodong Ma, Zhihao Liu, Jinyong Peng, Jianbin Zhang, Zeyao Tang
This work aimed to develop and optimize several lipid nanocapsule formulations (LNCs) to encapsulate cisplatin (CDDP) for treatment of hepatocellular carcinoma. By comparing the effect of oil/surfactant ratio, lecithin content, and oil/surfactant type on LNC characteristics, two LNCs were selected as optimal formulations: HS15-LNC (Solutol HS 15/MCT/lecithin, 54.5:42.5:3%, w/w) and EL-LNC (Cremophor EL/MCT/lecithin, 54.5:42.5:3%, w/w). Both LNCs could effectively encapsulate CDDP with the encapsulation efficiency of 73...
April 20, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29678520/sorafenib-suppresses-tgf-%C3%AE-responses-by-inducing-caveolae-lipid-raft-mediated-internalization-degradation-of-cell-surface-type-ii-tgf-%C3%AE-receptors-implications-in-development-of-effective-adjunctive-therapy-for-hepatocellular-carcinoma
#15
Chih-Ling Chung, Shih-Wei Wang, Wei-Chih Sun, Chih-Wen Shu, Yu-Chen Kao, Meng-Shin Shiao, Chun-Lin Chen
Sorafenib is the only FDA approved drug for the treatment of advanced hepatocellular carcinoma (HCC) and other malignancies. Studies indicate that TGF-β signalling is associated with tumour progression in HCC. Autocrine and paracrine TGF-β promotes tumour growth and malignancy by inducing epithelial-mesenchymal transition (EMT). Sorafenib is believed to antagonize tumour progression by inhibiting TGF-β-induced EMT. It improves survival of patients but HCC later develops resistance and relapses. The underlying mechanism of resistance is unknown...
April 17, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29670525/mir-203-inhibits-alcohol-induced-hepatic-steatosis-by-targeting-lipin1
#16
Xiao-Yu Cheng, Jun-Da Liu, Xin-Yi Lu, Xing Yan, Cheng Huang, Xiao-Ming Meng, Jun Li
Alcoholic liver disease (ALD) is a global liver disease which characterized by liver inflammation, fatty liver, alcoholic hepatitis, or liver cirrhosis. Alcohol abuse is one of the main reasons for liver disease. Alcoholic fatty liver (AFL) disease is the early stage of ALD and associated with the excessive lipids accumulation in hepatocytes as well as oxidative stress. MicroRNA-203 (miR-203) is known to suppress the proliferation and metastasis of hepatocellular carcinoma, but the role in the progression of alcoholic liver disease is not clear and is warranted for further investigation...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29669827/osteopontin-regulates-hcv-replication-and-assembly-via-interaction-with-hcv-proteins-and-lipid-droplets-and-by-binding-to-receptors-%C3%AE-v%C3%AE-3-and-cd44
#17
Jawed Iqbal, Mehuli Sarkar-Dutta, Steven McRae, Akshaya Ramachandran, Binod Kumar, Gulam Waris
Hepatitis C virus (HCV) replication and assembly occur at the specialized site of endoplasmic reticulum (ER) membranes and lipid droplets (LDs), respectively. Recently, several host proteins have been shown to be involved in HCV replication and assembly. In the present study, we demonstrate the important relationship among osteopontin (OPN), ER and LDs. OPN is a secreted phosphoprotein and overexpression of OPN in hepatocellular carcinoma (HCC) tissue can lead to invasion and metastasis. OPN expression is also enhanced in HCV-associated HCC...
April 18, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29625129/a-negative-feedback-loop-between-microrna-378-and-nrf1-promotes-the-development-of-hepatosteatosis-in-mice-treated-with-a-high-fat-diet
#18
Tianpeng Zhang, Xiaoling Zhao, Clifford J Steer, Guiqin Yan, Guisheng Song
BACKGROUNDS: The incidence of nonalcoholic fatty liver disease (NAFLD) is rapidly increasing due to the prevalence of obesity. NAFLD is a major risk factor of hepatocellular carcinoma (HCC). Even with successful surgical removal, the presence of NAFLD is associated with an increased recurrence of HCC. Despite the extensive study of NAFLD, its underlying mechanism(s) remains essentially unknown and there are no FDA-approved drugs for its treatment. Alterations in microRNA (miR) expression have been observed in human fatty livers...
April 3, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29625084/vitamin-c-deficiency-aggravates-tumor-necrosis-factor-%C3%AE-induced-insulin-resistance
#19
Zhou Qing, Wu Xiao-Hui, Wu Xi-Mei, Zou Chao-Chun
Chronic low-grade inflammation plays a major role in the development of insulin resistance. The potential role and underlying mechanism of vitamin C, an antioxidant and anti-inflammatory agent, was investigated in tumor necrosis factor-α (TNF-α)-induced insulin resistance. Gulonolactone oxidase knockout (Gulo-/- ) mice genetically unable to synthesize vitamin C were used to induce insulin resistance by continuously pumping small doses of TNF-α for seven days, and human liver hepatocellular carcinoma cells (HepG2 cells) were used to induce insulin resistance by treatment with TNF-α...
April 3, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29623561/nkt-cells-in-liver-diseases
#20
REVIEW
Shasha Zhu, Huimin Zhang, Li Bai
Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases. In this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liver diseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma...
April 6, 2018: Frontiers of Medicine
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