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https://www.readbyqxmd.com/read/29769031/presentation-and-outcomes-of-indigenous-australians-with-peripheral-artery-disease
#1
Tejas P Singh, Joseph V Moxon, Genevieve N Healy, Yvonne Cadet-James, Jonathan Golledge
BACKGROUND: The risk factors for peripheral artery disease (PAD) are more common in Indigenous than non-Indigenous Australians, however the presentation and outcome of PAD in Indigenous Australians has not been previously investigated. The aim of this prospective cohort study was to compare the presenting characteristics and clinical outcome of Indigenous and non-Indigenous Australians with PAD. METHODS: PAD patients were prospectively recruited and followed-up since 2003 from an outpatient vascular clinic in Townsville, Australia...
May 16, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29741759/anionic-nanoliposomes-reduced-atherosclerosis-progression-in-low-density-lipoprotein-receptor-ldlr-deficient-mice-fed-a-high-fat-diet
#2
Smriti M Krishna, Joseph V Moxon, Roby J Jose, Jiaze Li, Amirhossein Sahebkar, Mahmoud R Jaafari, Mahdi Hatamipour, Dawie Liu, Jonathan Golledge
Atherosclerosis is a systemic disease characterized by the deposition of cholesterol and inflammatory cells within the arterial wall. Removal of cholesterol from the vessel wall may have an impact on the size and composition of atherosclerotic lesions. Anionic phospholipids or liposome vesicles composed of a lipid bilayer such as nanoliposomes have been suggested as treatments for dyslipidemia. In this study, we investigated the effect of anionic nanoliposomes on atherosclerosis in a mouse model. Low-density lipoprotein receptor knockout mice (Ldlr-/- ) were fed with an atherosclerosis promoting high fat and cholesterol (HFC) diet for 12 weeks...
May 9, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29704910/hearing-loss-and-the-risk-of-dementia-in-later-life
#3
Andrew H Ford, Graeme J Hankey, Bu B Yeap, Jonathan Golledge, Leon Flicker, Osvaldo P Almeida
Dementia is a major source of disability worldwide and there are currently no available disease-modifying treatments. Hearing loss may be associated with increased risk of dementia in later life and therefore could be a modifiable risk factor, given the availability of efficacious interventions. We investigated the association of hearing loss and dementia through two complementary approaches: a prospective, cohort study of 37,898 older men (mean age 72.5 ± 4.6 years) with a mean follow-up of 11.1 years, and a systematic review and meta-analysis of prospective studies...
June 2018: Maturitas
https://www.readbyqxmd.com/read/29599722/cytokine-responses-to-acute-exercise-in-healthy-older-adults-the-effect-of-cardiorespiratory-fitness
#4
Mark T Windsor, Tom G Bailey, Maria Perissiou, Lara Meital, Jonathan Golledge, Fraser D Russell, Christopher D Askew
Markers of chronic inflammation increase with aging, and are associated with cardiovascular disease prevalence and mortality. Increases in fitness with exercise training have been associated with lower circulating concentrations of cytokines known to have pro-inflammatory actions (such as interleukin-6 [IL-6]) and higher circulating concentrations of anti-inflammatory cytokines (interleukin-10 [IL-10]). However, the effect of cardiorespiratory fitness on acute cytokine responses to a single bout of exercise in healthy older individuals is unknown...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29569879/the-penetration-of-methanol-into-bovine-cardiac-and-hepatic-tissues-is-faster-than-ethanol-and-formalin
#5
Michelle Steicke, Guang Yang, Tam Nguyen Dinh, Matthew Dunster-Jones, Owen Sargisson, Farah Ahmady, Jonathan Golledge, Yutang Wang
Methanol, ethanol and formalin are commonly used as fixatives to preserve biological tissues from decay in the preparation of histological sections. Fixation of the inner layers of the tissue depends on the ability of the fixative to diffuse into the tissue. It is unknown whether methanol penetrates tissues at similar rates to other fixatives. This study aimed to compare the penetration rates of methanol, ethanol and formalin into bovine heart and liver tissues. The penetration distance and tissue shrinkage or expansion were measured by analysing the digital images of tissue before and after immersion in different fixatives for 1, 2, 6 or 10 h...
February 7, 2018: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29564993/risk-of-dementia-associated-with-psychotic-disorders-in-later-life-the-health-in-men-study-hims
#6
Osvaldo P Almeida, Andrew H Ford, Graeme J Hankey, Bu B Yeap, Jonathan Golledge, Leon Flicker
BACKGROUND: Recent research has identified several potentially modifiable risk factors for dementia, including mental disorders. Psychotic disorders, such as schizophrenia and delusional disorder, have also been associated with increased risk of cognitive impairment and dementia, but currently available data difficult to generalise because of bias and confounding. We designed the present study to investigate if the presence of a psychotic disorder increased the risk of incident dementia in later life...
March 22, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29390287/the-association-between-serum-uric-acid-and-blood-pressure-in-different-age-groups-in-a-healthy-chinese-cohort
#7
Wenjuan Cheng, Shiling Wen, Yutang Wang, Zhiping Qian, Yuyao Tan, Hongying Li, Yueli Hou, Haiyang Hu, Jonathan Golledge, Guang Yang
High serum uric acid (sUA) has been reported to be a risk factor for hypertension however, whether this is the case for all age groups is not clear. We examined the association between sUA concentrations and systolic and diastolic blood pressure (SBP and DBP) in different age groups in a cohort of healthy Chinese participants.A total of 1082 healthy participants aged from 41 to 70 years were included. sUA concentration was measured by the uricase-peroxidase method. SBP and DBP were assessed using mercury sphygmomanometry...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29311219/diabetes-reduces-severity-of-aortic-aneurysms-depending-on-the-presence-of-cell-division-autoantigen-1-cda1
#8
Jiaze Li, Pacific Huynh, Aozhi Dai, Tieqiao Wu, Yugang Tu, Bryna Chow, Helen Kiriazis, Xiao-Jun Du, Leon A Bach, Jennifer L Wilkinson-Berka, Erik Biros, Philip Walker, Maria Nataatmadja, Malcolm West, Jonathan Golledge, Terri J Allen, Mark E Cooper, Zhonglin Chai
Diabetes is a negative risk factor for aortic aneurysm, but the underlying explanation for this phenomenon is unknown. We have previously demonstrated that cell division autoantigen 1 (CDA1), which enhances transforming growth factor-β signaling, is upregulated in diabetes. We hypothesized that CDA1 plays a key role in conferring the protective effect of diabetes against aortic aneurysms. Male wild-type, CDA1 knockout (KO), apolipoprotein E (ApoE) KO, and CDA1/ApoE double-KO (dKO) mice were rendered diabetic...
April 2018: Diabetes
https://www.readbyqxmd.com/read/29284388/fenofibrate-and-telmisartan-in-the-management-of-abdominal-aortic-aneurysm
#9
Sophie E Rowbotham, Smriti M Krishna, Corey S Moran, Jonathan Golledge
Objective This mini-review provides the rationale and updated progress for ongoing randomized controlled trials assessing fenofibrate and telmisartan efficacy to limit abdominal aortic aneurysm (AAA) growth. Methods / Results Data from preclinical and human studies investigating the efficacy of fenofibrate and telmisartan to limit AAA growth is presented and provides the rationale for three current randomized controlled trials assessing these medications as potential interventions to limit aneurysm growth in AAA patients...
December 27, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29210916/acute-inflammatory-responses-to-exercise-in-patients-with-abdominal-aortic-aneurysm
#10
Mark T Windsor, Tom G Bailey, Maria Perissiou, Kim Greaves, Pankaj Jha, Anthony S Leicht, Fraser D Russell, Jonathan Golledge, Christopher D Askew
PURPOSE: Inflammation and extracellular matrix degeneration contribute to abdominal aortic aneurysm (AAA) development. We aimed to assess the effect of exercise intensity on circulating biomarkers of inflammation and extracellular matrix degeneration in patients with AAA and healthy older adults. METHODS: Twenty patients with AAA (74±6y) and twenty healthy males (72±5y) completed moderate-intensity cycling at 40% peak power output (PPO), higher-intensity intervals at 70% PPO, and control (rest) on separate days...
November 27, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29180456/body-mass-index-and-vascular-disease-in-men-aged-65-years-and-over-hims-health-in-men-study
#11
Ben Lacey, Bu B Yeap, Jonathan Golledge, Sarah Lewington, Kieran A McCaul, Paul E Norman, Leon Flicker, Osvaldo P Almeida, Graeme J Hankey
BACKGROUND: Understanding the relationship between body mass index (BMI) and vascular disease at older age has become increasingly important in the many countries where both average age and BMI are rising. METHODS AND RESULTS: In this prospective cohort study, 12 203 men (aged ≥65) were recruited in 1996-1999 from the general population in Perth, Australia. To limit reverse causality, analyses excluded those with past vascular disease and the first 4 years of follow-up...
November 27, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29145894/inositol-in-the-management-of-abdominal-aortic-aneurysm-imagen-study-protocol-for-a-randomised-controlled-trial
#12
Sophie E Rowbotham, Jenna L Pinchbeck, Georgina Anderson, Bernie Bourke, Michael Bourke, T Christian Gasser, Rene Jaeggi, Jason S Jenkins, Corey S Moran, Susan K Morton, Christopher M Reid, Ramesh Velu, Lisan Yip, Joseph V Moxon, Jonathan Golledge
BACKGROUND: An abdominal aortic aneurysm (AAA) is a focal dilation of the abdominal aorta and is associated with a risk of fatal rupture. Experimental studies suggest that myo-inositol may exert beneficial effects on AAAs through favourable changes to biological pathways implicated in AAA pathology. The aim of the Inositol in the MAnaGemENt of abdominal aortic aneurysm (IMAGEN) trial is to assess if myo-inositol will reduce AAA growth. METHODS/DESIGN: IMAGEN is a multi-centre, prospective, parallel-group, randomised, double-blind, placebo-controlled trial...
November 16, 2017: Trials
https://www.readbyqxmd.com/read/29133273/plasma-free-thyroxine-in-the-upper-quartile-is-associated-with-an-increased-incidence-of-major-cardiovascular-events-in-older-men-that-do-not-have-thyroid-dysfunction-according-to-conventional-criteria
#13
Jonathan Golledge, Graeme J Hankey, Osvaldo P Almeida, Leon Flicker, Paul E Norman, Bu B Yeap
BACKGROUND: The aim of this study was to assess the association of plasma free thyroxine (FT4) and serum thyroid stimulating hormone (TSH) concentrations with the past diagnosis of cardiovascular disease and incidence of new cardiovascular events in older men with no known thyroid disease. METHODS: This study involved a cohort of community-recruited older men without known thyroid disease. Plasma FT4 and serum TSH were measured by immunoassay. Past cardiovascular disease diagnosis was defined through questionnaire data...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29128328/circulating-micrornas-as-biomarkers-for-acute-ischemic-stroke-a-systematic-review
#14
Brittany Dewdney, Alexandra Trollope, Joseph Moxon, Diana Thomas Manapurathe, Erik Biros, Jonathan Golledge
BACKGROUND: Acute ischemic stroke is a leading cause of death and disability worldwide. Unlike myocardial infarction, there is no current blood test to diagnose acute ischemic stroke. MicroRNAs (miRNAs) are very stable in the blood and have been suggested as potential diagnostic markers. MATERIALS AND METHODS: This review aimed to systematically assess case-control studies investigating the association of circulating miRNAs with acute ischemic stroke. Medline, CINAHL, Cochrane Library, Web of Science, Scopus, and PubMed were searched for studies that examined the association of circulating miRNAs in patients with acute ischemic stroke...
March 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29104559/optimizing-the-definitions-of-stroke-transient-ischemic-attack-and-infarction-for-research-and-application-in-clinical-practice
#15
Anne L Abbott, Mauro Silvestrini, Raffi Topakian, Jonathan Golledge, Alejandro M Brunser, Gert J de Borst, Robert E Harbaugh, Fergus N Doubal, Tatjana Rundek, Ankur Thapar, Alun H Davies, Anthony Kam, Joanna M Wardlaw
Background and purpose: Until now, stroke and transient ischemic attack (TIA) have been clinically based terms which describe the presence and duration of characteristic neurological deficits attributable to intrinsic disorders of particular arteries supplying the brain, retina, or (sometimes) the spinal cord. Further, infarction has been pathologically defined as death of neural tissue due to reduced blood supply. Recently, it has been proposed we shift to definitions of stroke and TIA determined by neuroimaging results alone and that neuroimaging findings be equated with infarction...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29044573/higher-igfbp3-is-associated-with-increased-incidence-of-colorectal-cancer-in-older-men-independently-of-igf1
#16
Yi X Chan, Helman Alfonso, Stephen Anthony Paul Chubb, Ken K Y Ho, Peter Gerard Fegan, Graeme J Hankey, Jonathan Golledge, Leon Flicker, Bu B Yeap
OBJECTIVE: Insulin-like growth factor 1 (IGF1) has anabolic and growth-promoting effects, raising concerns regarding its potential to promote tumour growth. Circulating IGF1 is bound to binding proteins, which modulate bioavailability of IGF1. This study assessed the associations of IGF1 and its binding proteins 1 (IGFBP1) and 3 (IGFBP3) with cancer risk. DESIGN: A prospective cohort study of 4042 men aged ≥70 years. METHODS: Plasma total IGF1, IGFBP1 and IGFBP3 were measured between 2001 and 2004...
February 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/28939648/effects-of-acute-exercise-on-endothelial-function-in-patients-with-abdominal-aortic-aneurysm
#17
Tom G Bailey, Maria Perissiou, Mark T Windsor, Karl Schulze, Michael Nam, Rebecca Magee, Anthony S Leicht, Daniel J Green, Kim Greaves, Jonathan Golledge, Christopher D Askew
Endothelial dysfunction is observed in patients with abdominal aortic aneurysm (AAA), who have increased risk of cardiovascular events and mortality. This study aimed to assess the acute effects of moderate- and higher-intensity exercise on endothelial function, as assessed by flow-mediated dilation (FMD), in AAA patients (74 ± 6 yr old, n = 22) and healthy adults (72 ± 5 yr old, n = 22). Participants undertook three randomized visits, including moderate-intensity continuous exercise [40% peak power output (PPO)], higher-intensity interval exercise (70% PPO), and a no-exercise control...
January 1, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28935757/resveratrol-inhibits-growth-of-experimental-abdominal-aortic-aneurysm-associated-with-upregulation-of-angiotensin-converting-enzyme-2
#18
Corey S Moran, Erik Biros, Smriti M Krishna, Yutang Wang, Chris Tikellis, Susan K Morton, Joseph V Moxon, Mark E Cooper, Paul E Norman, Louise M Burrell, Merlin C Thomas, Jonathan Golledge
OBJECTIVE: Recent evidence suggests an important role for angiotensin-converting enzyme 2 (ACE2) in limiting abdominal aortic aneurysm (AAA). This study examined the effect of ACE2 deficiency on AAA development and the efficacy of resveratrol to upregulate ACE2 in experimental AAA. APPROACH AND RESULTS: Ace2 deletion in apolipoprotein-deficient mice (ApoE(-/-)Ace2(-/y) ) resulted in increased aortic diameter and spontaneous aneurysm of the suprarenal aorta associated with increased expression of inflammation and proteolytic enzyme markers...
November 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28900099/rapid-global-ocean-atmosphere-response-to-southern-ocean-freshening-during-the-last-glacial
#19
Chris S M Turney, Richard T Jones, Steven J Phipps, Zoë Thomas, Alan Hogg, A Peter Kershaw, Christopher J Fogwill, Jonathan Palmer, Christopher Bronk Ramsey, Florian Adolphi, Raimund Muscheler, Konrad A Hughen, Richard A Staff, Mark Grosvenor, Nicholas R Golledge, Sune Olander Rasmussen, David K Hutchinson, Simon Haberle, Andrew Lorrey, Gretel Boswijk, Alan Cooper
Contrasting Greenland and Antarctic temperatures during the last glacial period (115,000 to 11,650 years ago) are thought to have been driven by imbalances in the rates of formation of North Atlantic and Antarctic Deep Water (the 'bipolar seesaw'). Here we exploit a bidecadally resolved14 C data set obtained from New Zealand kauri (Agathis australis) to undertake high-precision alignment of key climate data sets spanning iceberg-rafted debris event Heinrich 3 and Greenland Interstadial (GI) 5.1 in the North Atlantic (~30,400 to 28,400 years ago)...
September 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28859075/plantar-pressures-are-elevated-in-people-with-longstanding-diabetes-related-foot-ulcers-during-follow-up
#20
Malindu E Fernando, Robert G Crowther, Peter A Lazzarini, Saiumaeswar Yogakanthi, Kunwarjit S Sangla, Petra Buttner, Rhondda Jones, Jonathan Golledge
OBJECTIVE: High plantar pressures are implicated in the development of diabetes-related foot ulcers. Whether plantar pressures remain high in patients with chronic diabetes-related foot ulcers over time is uncertain. The primary aim of this study was to compare plantar pressures at baseline and three and six months later in participants with chronic diabetes-related foot ulcers (cases) to participants without foot ulcers (controls). METHODS: Standardised protocols were used to measure mean peak plantar pressure and pressure-time integral at 10 plantar foot sites (the hallux, toes, metatarsals 1 to 5, mid-foot, medial heel and lateral heel) during barefoot walking...
2017: PloS One
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