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REVIEW
Justin Smith, Danielle Margalit, Jonathan Golledge, Domenico Nastasi, Anju Nohria, Lachlan McDowell
PURPOSE: The purpose of this review is to summarize the literature on carotid artery stenosis (CAS) and ischemic stroke (IS) in head and neck cancer (HNC) patients treated with radiotherapy (RT) to guide assessment, screening, and management strategies. RESULTS: Patients treated with RT for HNC are at an elevated risk of developing CAS with published meta-analyses demonstrating that CAS >50% occurs in approximately 25% of patients. Previous research suggests a 10-year cumulative incidence of stroke between 5...
April 5, 2024: International Journal of Radiation Oncology, Biology, Physics
#2
REVIEW
Kevin Tian, Shivshankar Thanigaimani, Kate Gibson, Jonathan Golledge
OBJECTIVE: Whether angiotensin II blockade is an effective medical treatment for abdominal aortic aneurysms (AAAs) has not been established. This systematic review and meta-analysis aimed to determine the association of angiotensin converting enzyme inhibitor (ACEi) and angiotensin receptor blocker (ARB) prescription with AAA growth and events. DATA SOURCES: MEDLINE, Embase, Scopus, Web of Science, and the Cochrane Library databases were searched from their inception to 4 January 2024, with no language restrictions...
March 25, 2024: European Journal of Vascular and Endovascular Surgery
#3
REVIEW
Bibi Rabia, Shivshankar Thanigaimani, Jonathan Golledge
BACKGROUND: Abdominal aortic aneurysm (AAA) is a weakening and expansion of the abdominal aorta. Currently, there is no drug treatment to limit AAA growth. The glycocalyx (GC) is the outermost layer of the cell surface, mainly composed of glycosaminoglycans (GAGs) and proteoglycans. OBJECTIVE: The aim of this review was to identify a potential relationship between GC disruption and AAA pathogenesis. METHODS: A narrative review of relevant published research was conducted...
March 8, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
#4
JOURNAL ARTICLE
Anders Wanhainen, Isabelle Van Herzeele, Frederico Bastos Goncalves, Sergi Bellmunt Montoya, Xavier Berard, Jonathan R Boyle, Mario D'Oria, Carlota F Prendes, Christos D Karkos, Arkadiusz Kazimierczak, Mark J W Koelemay, Tilo Kölbel, Kevin Mani, Germano Melissano, Janet T Powell, Santi Trimarchi, Nikolaos Tsilimparis, George A Antoniou, Martin Björck, Raphael Coscas, Nuno V Dias, Philippe Kolh, Sandro Lepidi, Barend M E Mees, Timothy A Resch, Jean Baptiste Ricco, Riikka Tulamo, Christopher P Twine, Daniela Branzan, Stephen W K Cheng, Ronald L Dalman, Florian Dick, Jonathan Golledge, Stephan Haulon, Joost A van Herwaarden, Nikola S Ilic, Arkadiusz Jawien, Tara M Mastracci, Gustavo S Oderich, Fabio Verzini, Kak Khee Yeung
OBJECTIVE: The European Society for Vascular Surgery (ESVS) has developed clinical practice guidelines for the care of patients with aneurysms of the abdominal aorta and iliac arteries in succession to the 2011 and 2019 versions, with the aim of assisting physicians and patients in selecting the best management strategy. METHODS: The guideline is based on scientific evidence completed with expert opinion on the matter. By summarising and evaluating the best available evidence, recommendations for the evaluation and treatment of patients have been formulated...
February 2024: European Journal of Vascular and Endovascular Surgery
#5
REVIEW
Parveen K Garg, Harpreet S Bhatia, Tara S Allen, Tabitha Grainger, Anna L Pouncey, David Dichek, Renu Virmani, Jonathan Golledge, Matthew A Allison, Janet T Powell
BACKGROUND: One strategy to reduce the burden of cardiovascular disease is the early detection and treatment of atherosclerosis. This has led to significant interest in studies of subclinical atherosclerosis, using different phenotypes, not all of which are accurate reflections of the presence of asymptomatic atherosclerotic plaques. The aim of part 2 of this series is to provide a review of the existing literature on purported measures of subclinical disease and recommendations concerning which tests may be appropriate in the prevention of incident cardiovascular disease...
January 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
#6
REVIEW
Siân P Cartland, Christopher P Stanley, Christina Bursill, Freda Passam, Gemma A Figtree, Sanjay Patel, Jacky Loa, Jonathan Golledge, David A Robinson, Sarah J Aitken, Mary M Kavurma
Peripheral artery disease (PAD) is caused by blocked arteries due to atherosclerosis and/or thrombosis which reduce blood flow to the lower limbs. It results in major morbidity, including ischemic limb, claudication, and amputation, with patients also suffering a heightened risk of heart attack, stroke, and death. Recent studies suggest women have a higher prevalence of PAD than men, and with worse outcomes after intervention. In addition to a potential unconscious bias faced by women with PAD in the health system, with underdiagnosis, and lower rates of guideline-based therapy, fundamental biological differences between men and women may be important...
December 13, 2023: International Journal of Molecular Sciences
#7
JOURNAL ARTICLE
Qiuguo Wang, Guihuan Chen, Zhen Qi, Yifan Zeng, Ling Tan, Hao Tang
BACKGROUND: Aortic aneurysm is a chronic arterial disease that can lead to aortic rupture, causing severe complications and life-threatening risks for patients, and it is one of the common causes of death among the elderly. Increasing evidence suggests that inflammation plays an important role in the progression of aortic aneurysm. However, there is a lack of literature-based quantitative analysis in this field. METHODS: Up to March 30, 2023, we collected 3,993 articles related to aortic aneurysm and inflammation from the Web of Science Core Collection (WoSCC) database for bibliometric analysis...
2023: Frontiers in Cardiovascular Medicine
#8
JOURNAL ARTICLE
Stephanie Y Tan, S A Paul Chubb, Leon Flicker, Osvaldo P Almeida, Jonathan Golledge, Graeme J Hankey, Bu B Yeap
OBJECTIVE: Prevalence of subclinical thyroid disease increases with age, but optimal detection and surveillance strategies remain unclear particularly for older men. We aimed to assess thyroid stimulating hormone (TSH) and free thyroxine (FT4) concentrations and their longitudinal changes, to determine the prevalence and incidence of subclinical thyroid dysfunction in older men. DESIGN, PARTICIPANTS AND MEASUREMENTS: Longitudinal study of 994 community-dwelling men aged ≥70 years without known or current thyroid disease, with TSH and FT4 concentrations assessed at baseline and follow-up (after 8...
December 7, 2023: Clinical Endocrinology
#9
JOURNAL ARTICLE
Joseph V Moxon, Andrew Calcino, Ann-Katrin Kraeuter, James Phie, Georgina Anderson, Glenys Standley, Cindy Sealey, Rhondda E Jones, Matt A Field, Jonathan Golledge
BACKGROUND: Past studies suggest that there are changes in peripheral blood cell gene expression in response to ischaemic stroke; however, the specific changes which occur during the acute phase are poorly characterised. The current study aimed to identify peripheral blood cell genes specifically associated with the early response to ischaemic stroke using whole blood samples collected from participants diagnosed with ischaemic stroke (n = 29) or stroke mimics (n = 27) following emergency presentation to hospital...
November 25, 2023: Human Genomics
#10
JOURNAL ARTICLE
Yutang Wang, Owen Sargisson, Dinh Tam Nguyen, Ketura Parker, Stephan J R Pyke, Ahmed Alramahi, Liam Thihlum, Yan Fang, Morgan E Wallace, Stuart P Berzins, Ernesto Oqueli, Dianna J Magliano, Jonathan Golledge
The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an urgent need for more research in this field. Increased vascular inflammation and enhanced apoptosis of vascular smooth muscle cells (VSMCs) are implicated in AAA formation. Here, we investigated whether hydralazine, which has anti-inflammatory and anti-apoptotic properties, inhibited AAA formation and pathological hallmarks...
November 3, 2023: International Journal of Molecular Sciences
#11
REVIEW
Aaron Drovandi, Leonard Seng, Jonathan Golledge
This systematic review and meta-analysis pooled evidence from randomised controlled trials (RCTs) on the effectiveness of educational programs for people with or at risk of diabetes-related foot disease (DFD). A systematic search identified RCTs evaluating the effectiveness of educational programs in preventing or managing DFD. The primary outcome was risk of developing a foot ulcer. Secondary outcomes included any amputation, mortality, changes in cardiovascular risk factors, foot-care knowledge and self-care behaviours...
November 5, 2023: Diabetes/metabolism Research and Reviews
#12
JOURNAL ARTICLE
Jonathan Golledge, Alkira Venn, Joseph V Moxon
No abstract text is available yet for this article.
October 18, 2023: JAMA Cardiology
#13
REVIEW
Jonathan Golledge
PURPOSE: This narrative review summarizes recent research examining treatment targets for peripheral artery disease (PAD)-related limb ischemia. METHODS: Targeted searches of the PubMed and clinical trial registry databases were performed to identify recent findings from animal models of limb ischemia and clinical studies examining PAD progression and treatment. Ongoing clinical trials testing new treatments for PAD were also reviewed. Relevant full-text articles were retrieved and critically reviewed...
September 26, 2023: Clinical Therapeutics
#14
JOURNAL ARTICLE
Elizabeth H Lim, Peter Franklin, Michelle L Trevenen, Mark Nieuwenhuijsen, Bu B Yeap, Osvaldo P Almeida, Graeme J Hankey, Jonathan Golledge, Christopher Etherton-Beer, Leon Flicker, Suzanne Robinson, Jane Heyworth
BACKGROUND: Air pollution is a cause of lung cancer and is associated with bladder cancer. However, the relationship between air pollution and these cancers in regions of low pollution is unclear. We investigated associations between fine particulate matter (PM2.5 ), nitrogen dioxide, and black carbon (BC), and both these cancers in a low-pollution city. METHODS: A cohort of 11,679 men ≥65 years old in Perth (Western Australia) were followed from 1996-1999 until 2018...
September 8, 2023: British Journal of Cancer
#15
JOURNAL ARTICLE
Jonathan Golledge
No abstract text is available yet for this article.
August 31, 2023: Cardiovascular Research
#16
REVIEW
Jonathan Golledge, Shivshankar Thanigaimani, Kristen S Barratt, Gian Paolo Fadini
Diabetes is a key risk factor for ischaemic foot disease, which causes pain, tissue loss, hospital admission, and major amputation. Currently, treatment focuses on revascularisation, but many patients are unsuitable for surgery and revascularisation is frequently unsuccessful. The authors describe recent research in animal models and clinical trials investigating novel medical targets for ischaemia, including theories about impaired wound healing, animal models for limb ischaemia and recent randomised controlled trials testing novel medical therapies...
August 10, 2023: Diabetes/metabolism Research and Reviews
#17
JOURNAL ARTICLE
Joshua S Jones, Lee Nedkoff, Jane S Heyworth, Osvaldo P Almeida, Leon Flicker, Jonathan Golledge, Graeme J Hankey, Elizabeth H Lim, Mark Nieuwenhuijsen, Bu B Yeap, Michelle L Trevenen
UNLABELLED: Exposure to particulate matter with an aerodynamic diameter less than or equal to 2.5 μm (PM2.5 ) is associated with increased risk of heart disease, but less is known about the relationship at low concentrations. This study aimed to determine the dose-response relationship between long-term PM2.5 exposure and risk of incident ischemic heart disease (IHD), incident heart failure (HF), and incident atrial fibrillation (AF) in older men living in a region with relatively low ambient air pollution...
August 2023: Environmental Epidemiology
#18
REVIEW
Shannon A Wong, Aaron Drovandi, Rhondda Jones, Jonathan Golledge
This systematic review pooled evidence from randomised controlled trials (RCTs) on the effectiveness of dietary upregulators of nitric oxide (NO) in improving the walking and quality of life of patients with peripheral artery disease (PAD). RCTs examining the effect of dietary upregulators of NO in patients with PAD were included. The primary outcome was the maximum walking distance. Secondary outcomes were the initial claudication distance, the six-minute walking distance, quality of life, the ankle-brachial pressure index (ABI), adverse events and risk of mortality, revascularisation or amputation...
June 29, 2023: Biomedicines
#19
JOURNAL ARTICLE
Osvaldo P Almeida, Graeme J Hankey, Bu B Yeap, Jonathan Golledge, Christopher Etherton-Beer, Suzanne Robinson, Leon Flicker
OBJECTIVE: To determine the prevalence of common mental disorders among older Australians included in the Health In Men Data Linkage Study and compare those with the results of the 2020-2021 National Study of Mental Health and Wellbeing (NSMHW). METHOD: We used longitudinal record linkage to estimate the prevalence of mental disorders from age 65 years in a random sample of 38173 Australian men aged 65-85 years living in the Perth metropolitan region. Outcome was the proportion of participants affected by depressive episodes or dysthymia, bipolar disorder, anxiety disorder, psychotic disorder and alcohol use disorder...
July 26, 2023: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
#20
REVIEW
Jonathan Golledge, Shivshankar Thanigaimani, Janet T Powell, Phil S Tsao
Abdominal aortic aneurysm (AAA) causes ∼170 000 deaths annually worldwide. Most guidelines recommend asymptomatic small AAAs (30 to <50 mm in women; 30 to <55 mm in men) are monitored by imaging and large asymptomatic, symptomatic, and ruptured AAAs are considered for surgical repair. Advances in AAA repair techniques have occurred, but a remaining priority is therapies to limit AAA growth and rupture. This review outlines research on AAA pathogenesis and therapies to limit AAA growth. Genome-wide association studies have identified novel drug targets, e...
August 1, 2023: European Heart Journal
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