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Jonathan golledge

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https://www.readbyqxmd.com/read/29145894/inositol-in-the-management-of-abdominal-aortic-aneurysm-imagen-study-protocol-for-a-randomised-controlled-trial
#1
Sophie E Rowbotham, Jenna L Pinchbeck, Georgina Anderson, Bernie Bourke, Michael Bourke, T Christian Gasser, Rene Jaeggi, Jason S Jenkins, Corey S Moran, Susan K Morton, Christopher M Reid, Ramesh Velu, Lisan Yip, Joseph V Moxon, Jonathan Golledge
BACKGROUND: An abdominal aortic aneurysm (AAA) is a focal dilation of the abdominal aorta and is associated with a risk of fatal rupture. Experimental studies suggest that myo-inositol may exert beneficial effects on AAAs through favourable changes to biological pathways implicated in AAA pathology. The aim of the Inositol in the MAnaGemENt of abdominal aortic aneurysm (IMAGEN) trial is to assess if myo-inositol will reduce AAA growth. METHODS/DESIGN: IMAGEN is a multi-centre, prospective, parallel-group, randomised, double-blind, placebo-controlled trial...
November 16, 2017: Trials
https://www.readbyqxmd.com/read/29133273/plasma-free-thyroxine-in-the-upper-quartile-is-associated-with-an-increased-incidence-of-major-cardiovascular-events-in-older-men-that-do-not-have-thyroid-dysfunction-according-to-conventional-criteria
#2
Jonathan Golledge, Graeme J Hankey, Osvaldo P Almeida, Leon Flicker, Paul E Norman, Bu B Yeap
BACKGROUND: The aim of this study was to assess the association of plasma free thyroxine (FT4) and serum thyroid stimulating hormone (TSH) concentrations with the past diagnosis of cardiovascular disease and incidence of new cardiovascular events in older men with no known thyroid disease. METHODS: This study involved a cohort of community-recruited older men without known thyroid disease. Plasma FT4 and serum TSH were measured by immunoassay. Past cardiovascular disease diagnosis was defined through questionnaire data...
October 29, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29128328/circulating-micrornas-as-biomarkers-for-acute-ischemic-stroke-a-systematic-review
#3
Brittany Dewdney, Alexandra Trollope, Joseph Moxon, Diana Thomas Manapurathe, Erik Biros, Jonathan Golledge
BACKGROUND: Acute ischemic stroke is a leading cause of death and disability worldwide. Unlike myocardial infarction, there is no current blood test to diagnose acute ischemic stroke. MicroRNAs (miRNAs) are very stable in the blood and have been suggested as potential diagnostic markers. MATERIALS AND METHODS: This review aimed to systematically assess case-control studies investigating the association of circulating miRNAs with acute ischemic stroke. Medline, CINAHL, Cochrane Library, Web of Science, Scopus, and PubMed were searched for studies that examined the association of circulating miRNAs in patients with acute ischemic stroke...
November 8, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29104559/optimizing-the-definitions-of-stroke-transient-ischemic-attack-and-infarction-for-research-and-application-in-clinical-practice
#4
Anne L Abbott, Mauro Silvestrini, Raffi Topakian, Jonathan Golledge, Alejandro M Brunser, Gert J de Borst, Robert E Harbaugh, Fergus N Doubal, Tatjana Rundek, Ankur Thapar, Alun H Davies, Anthony Kam, Joanna M Wardlaw
Background and purpose: Until now, stroke and transient ischemic attack (TIA) have been clinically based terms which describe the presence and duration of characteristic neurological deficits attributable to intrinsic disorders of particular arteries supplying the brain, retina, or (sometimes) the spinal cord. Further, infarction has been pathologically defined as death of neural tissue due to reduced blood supply. Recently, it has been proposed we shift to definitions of stroke and TIA determined by neuroimaging results alone and that neuroimaging findings be equated with infarction...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29044573/higher-igfb3-is-associated-with-increased-incidence-of-colorectal-cancer-in-older-men-independently-of-igf1
#5
Yi X Chan, Helman Alfonso, Stephen Anthony Paul Chubb, Ken K Y Ho, Peter Gerard Fegan, Graeme J Hankey, Jonathan Golledge, Leon Flicker, Bu B Yeap
OBJECTIVE: Insulin-like growth factor 1 (IGF1) has anabolic and growth-promoting effects, raising concerns regarding its potential to promote tumour growth. Circulating IGF1 is bound to binding proteins, which modulate bioavailability of IGF1. This study assessed the associations of IGF1 and its binding proteins 1 (IGFBP1) and 3 (IGFBP3) with cancer risk. DESIGN: A prospective cohort study of 4042 men aged ≥70 years. METHODS: Plasma total IGF1, IGFBP1 and IGFBP3 were measured between 2001 and 2004...
October 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28939648/effects-of-acute-exercise-on-endothelial-function-in-abdominal-aortic-aneurysm-patients
#6
Tom G Bailey, Maria Perissiou, Mark Windsor, Karl Schulze, Michael Nam, Rebecca Magee, Anthony S Leicht, Daniel J Green, Kim Greaves, Jonathan Golledge, Christopher D Askew
Endothelial dysfunction is observed in patients with abdominal aortic aneurysm (AAA), who have increased risk of cardiovascular events and mortality. This study aimed to assess the acute effects of moderate and higher-intensity exercise on endothelial function, as assessed by flow-mediated-dilation (FMD), in AAA patients (n=22; 74±6 y) and healthy adults (n=22; 72±5y). Participants undertook three randomised visits, including moderate-intensity continuous exercise (40% peak power output, PPO), higher-intensity interval exercise (70% PPO), and a no-exercise control...
September 22, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28935757/resveratrol-inhibits-growth-of-experimental-abdominal-aortic-aneurysm-associated-with-upregulation-of-angiotensin-converting-enzyme-2
#7
Corey S Moran, Erik Biros, Smriti M Krishna, Yutang Wang, Chris Tikellis, Susan K Morton, Joseph V Moxon, Mark E Cooper, Paul E Norman, Louise M Burrell, Merlin C Thomas, Jonathan Golledge
OBJECTIVE: Recent evidence suggests an important role for angiotensin-converting enzyme 2 (ACE2) in limiting abdominal aortic aneurysm (AAA). This study examined the effect of ACE2 deficiency on AAA development and the efficacy of resveratrol to upregulate ACE2 in experimental AAA. APPROACH AND RESULTS: Ace2 deletion in apolipoprotein-deficient mice (ApoE(-/-)Ace2(-/y) ) resulted in increased aortic diameter and spontaneous aneurysm of the suprarenal aorta associated with increased expression of inflammation and proteolytic enzyme markers...
November 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28900099/rapid-global-ocean-atmosphere-response-to-southern-ocean-freshening-during-the-last-glacial
#8
Chris S M Turney, Richard T Jones, Steven J Phipps, Zoë Thomas, Alan Hogg, A Peter Kershaw, Christopher J Fogwill, Jonathan Palmer, Christopher Bronk Ramsey, Florian Adolphi, Raimund Muscheler, Konrad A Hughen, Richard A Staff, Mark Grosvenor, Nicholas R Golledge, Sune Olander Rasmussen, David K Hutchinson, Simon Haberle, Andrew Lorrey, Gretel Boswijk, Alan Cooper
Contrasting Greenland and Antarctic temperatures during the last glacial period (115,000 to 11,650 years ago) are thought to have been driven by imbalances in the rates of formation of North Atlantic and Antarctic Deep Water (the 'bipolar seesaw'). Here we exploit a bidecadally resolved (14)C data set obtained from New Zealand kauri (Agathis australis) to undertake high-precision alignment of key climate data sets spanning iceberg-rafted debris event Heinrich 3 and Greenland Interstadial (GI) 5.1 in the North Atlantic (~30,400 to 28,400 years ago)...
September 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28859075/plantar-pressures-are-elevated-in-people-with-longstanding-diabetes-related-foot-ulcers-during-follow-up
#9
Malindu E Fernando, Robert G Crowther, Peter A Lazzarini, Saiumaeswar Yogakanthi, Kunwarjit S Sangla, Petra Buttner, Rhondda Jones, Jonathan Golledge
OBJECTIVE: High plantar pressures are implicated in the development of diabetes-related foot ulcers. Whether plantar pressures remain high in patients with chronic diabetes-related foot ulcers over time is uncertain. The primary aim of this study was to compare plantar pressures at baseline and three and six months later in participants with chronic diabetes-related foot ulcers (cases) to participants without foot ulcers (controls). METHODS: Standardised protocols were used to measure mean peak plantar pressure and pressure-time integral at 10 plantar foot sites (the hallux, toes, metatarsals 1 to 5, mid-foot, medial heel and lateral heel) during barefoot walking...
2017: PloS One
https://www.readbyqxmd.com/read/28843790/circulating-biomarkers-are-not-associated-with-endoleaks-after-endovascular-repair-of-abdominal-aortic-aneurysms
#10
Joseph V Moxon, Eugene Ng, Sharon M Lazzaroni, Margaret Boult, Ramesh Velu, Robert A Fitridge, Jonathan Golledge
OBJECTIVE: Endoleak is a common complication of endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA) but can be detected only through prolonged follow-up with repeated aortic imaging. This study examined the potential for circulating matrix metalloproteinase 9 (MMP9), osteoprotegerin (OPG), D-dimer, homocysteine (HCY), and C-reactive protein (CRP) to act as diagnostic markers for endoleak in AAA patients undergoing elective EVAR. METHODS: Linear mixed-effects models were constructed to assess differences in AAA diameter after EVAR between groups of patients who did and did not develop endoleak during follow-up, adjusting for potential confounders...
August 23, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28742839/flavonols-reduce-aortic-atherosclerosis-lesion-area-in-apolipoprotein-e-deficient-mice-a-systematic-review-and-meta-analysis
#11
REVIEW
James Phie, Smriti M Krishna, Joseph V Moxon, Safraz M Omer, Robert Kinobe, Jonathan Golledge
Diets rich in flavonoids have been reported to have beneficial effects in the primary prevention of cardiovascular events. There are limited data, however, on the cardiovascular benefits of purified flavonoids. The aim of this systematic review and meta-analysis was to examine the reported effects of isolated flavonoids on aortic atherosclerosis in a mouse model. Medline, Pubmed, Science direct and Web of Science were searched to identify studies which examined the effect of isolated flavonoids on aortic atherosclerosis in apolipoprotein E deficient mice...
2017: PloS One
https://www.readbyqxmd.com/read/28728066/baseline-serum-phosphatidylcholine-plasmalogen-concentrations-are-inversely-associated-with-incident-myocardial-infarction-in-patients-with-mixed-peripheral-artery-disease-presentations
#12
Joseph V Moxon, Rhondda E Jones, Gerard Wong, Jacquelyn M Weir, Natalie A Mellett, Bronwyn A Kingwell, Peter J Meikle, Jonathan Golledge
BACKGROUND AND AIMS: Despite current best care, patients with peripheral artery disease (PAD) remain at high risk of myocardial infarction, and biomarkers to more accurately assess cardiovascular risk are needed. This study assessed the relationship between the serum lipidome and incident myocardial infarction in a cohort of PAD patients. METHODS: 265 PAD patients were followed up for a median of 23 months, during which 18 people suffered a myocardial infarction...
June 29, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28659610/upregulation-of-arylsulfatase-b-in-carotid-atherosclerosis-is-associated-with-symptoms-of-cerebral-embolization
#13
Erik Biros, Corey S Moran, Jane Maguire, Elizabeth Holliday, Christopher Levi, Jonathan Golledge
The aim of this study was to identify genes for which the expression within carotid atherosclerosis was reproducibly associated with the symptoms of cerebral embolization. Two publically available microarray datasets E-MEXP-2257 and GSE21545 were analysed using GeneSpring 11.5. The two datasets utilized a total of 22 and 126 carotid atherosclerosis samples, obtained from patients with and without symptoms of cerebral embolization, respectively. To assess whether the findings were reproducible we analysed carotid atherosclerosis samples from another 8 patients with and 7 patients without symptoms of cerebral embolization using real-time PCR...
June 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28575088/effect-of-blood-pressure-lowering-medications-on-leg-ischemia-in-peripheral-artery-disease-patients-a-meta-analysis-of-randomised-controlled-trials
#14
Diana Thomas Manapurathe, Smriti Murali Krishna, Brittany Dewdney, Joseph Vaughan Moxon, Erik Biros, Jonathan Golledge
BACKGROUND: It has been suggested that anti-hypertensive medications may worsen leg ischemia in peripheral artery disease (PAD) patients. We undertook a meta-analysis to assess the effect of anti-hypertensive medications on measures of leg ischemia including maximum walking distance (MWD), pain free walking distance (PFWD) and ankle brachial pressure index (ABPI). A meta-regression was performed to evaluate whether the effect of the anti-hypertensive medications on mean arterial pressure (MAP) was associated with changes in ABPI, MWD or PFWD...
2017: PloS One
https://www.readbyqxmd.com/read/28539162/longevity-klotho-gene-polymorphism-and-the-risk-of-dementia-in-older-men
#15
Osvaldo P Almeida, Bharti Morar, Graeme J Hankey, Bu B Yeap, Jonathan Golledge, Assen Jablensky, Leon Flicker
INTRODUCTION: Klotho variants (KL-VS) have been associated with increased longevity and better cognitive function. It is unclear whether they modulate dementia risk. METHODS: We recruited 527 men aged 71-87 years who were free of cognitive impairment. We used data linkage to track the onset of dementia over 10 years. KL-VS genotyping (rs9536314 T/G) followed standard procedures. RESULTS: The annual rate of dementia was 17.2‰ (95%CI=14.0-21...
July 2017: Maturitas
https://www.readbyqxmd.com/read/28450836/renal-denervation-promotes-atherosclerosis-in-hypertensive-apolipoprotein-e-deficient-mice-infused-with-angiotensin-ii
#16
Yutang Wang, Tam N Dinh, Alexander Nield, Smriti M Krishna, Kate Denton, Jonathan Golledge
Objective: To determine the effect of renal denervation (RDN) on the severity of atherosclerosis and aortic aneurysm in hypertensive mice. Methods: Hypertension, atherosclerosis and aortic aneurysm were induced by subcutaneous infusion of angiotensin II (1 μg/kg/min) for 28 days in apolipoprotein E-deficient mice. RDN was conducted using combined surgical and local chemical denervation. The norepinephrine concentration in the kidney was measured by high-performance liquid chromatography. Blood pressure was measured by the tail-cuff method...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28438901/systolic-blood-pressure-and-vascular-disease-in-men-aged-65-years-and-over-the-hims-health-in-men-study
#17
Ben Lacey, Jonathan Golledge, Bu B Yeap, Sarah Lewington, Kieran A McCaul, Paul E Norman, Leon Flicker, Osvaldo P Almeida, Graeme J Hankey
There is uncertainty about the relation between blood pressure and vascular disease at older age. We assessed the association of systolic blood pressure (SBP) and major vascular events in a prospective cohort study of 7564 men aged 65 to 94 years, recruited in 1996-1999 from the general population in Perth, Western Australia. SBP was measured at baseline and again at resurvey in 2001-2004. Participants were monitored for fatal and nonfatal vascular events. To limit the effect of reverse causality, analyses were restricted to men without previous vascular disease at baseline...
June 2017: Hypertension
https://www.readbyqxmd.com/read/28386544/use-of-nanoparticles-as-contrast-agents-for-the-functional-and-molecular-imaging-of-abdominal-aortic-aneurysm
#18
REVIEW
Theophilus I Emeto, Faith O Alele, Amy M Smith, Felicity M Smith, Tammy Dougan, Jonathan Golledge
Abdominal aortic aneurysm (AAA) is a degenerative disease of the aorta common in adults older than 65 years of age. AAA is usually imaged using ultrasound or computed tomography. Molecular imaging technologies employing nanoparticles (NPs) have been proposed as novel ways to quantify pathological processes, such as inflammation, within AAAs as a means to identify the risk of rapid progression or rupture. This article reviews the current evidence supporting the role of NP-based imaging in the management of AAA...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28364044/high-serum-thrombospondin-1-concentration-is-associated-with-slower-abdominal-aortic-aneurysm-growth-and-deficiency-of-thrombospondin-1-promotes-angiotensin-ii-induced-aortic-aneurysm-in-mice
#19
Smriti Murali Krishna, Sai Wang Seto, Roby Jose, Jiaze Li, Joseph Moxon, Paula Clancy, David J Crossman, Paul Norman, Theophilus I Emeto, Jonathan Golledge
Abdominal aortic aneurysm (AAA) is a common age-related vascular disease characterized by progressive weakening and dilatation of the aortic wall. Thrombospondin-1 (TSP-1; gene Thbs1) is a member of the matricellular protein family important in the control of extracellular matrix (ECM) remodelling. In the present study, the association of serum TSP-1 concentration with AAA progression was assessed in 276 men that underwent repeated ultrasound for a median 5.5 years. AAA growth was negatively correlated with serum TSP-1 concentration (Spearman's rho (-)0...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28347473/a-systematic-review-investigating-the-association-of-micrornas-with-human-abdominal-aortic-aneurysms
#20
REVIEW
Vikram Iyer, Sophie Rowbotham, Erik Biros, John Bingley, Jonathan Golledge
BACKGROUND AND AIMS: There is increasing interest in identifying novel methods for abdominal aortic aneurysm (AAA) diagnosis. Non-coding RNA molecules such as microRNAs (miRNAs) are stable within the circulation and may serve as biomarkers for AAA. This systematic review aimed to identify miRNAs associated with a diagnosis of human AAA based on currently published original research. METHODS: A systematic search of the MEDLINE and EMBASE databases identified studies assessing miRNA expression in abdominal aortic tissue or circulating blood from human AAA cases compared to non-aneurysmal controls...
June 2017: Atherosclerosis
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