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BPH, toxicology

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https://www.readbyqxmd.com/read/27747994/in-vivo-metabolic-investigation-of-silodosin-using-uhplc-qtof-ms-ms-and-in-silico-toxicological-screening-of-its-metabolites
#1
Chiguru Vishnuvardhan, Saibaba Baikadi, Roshan M Borkar, R Srinivas, N Satheeshkumar
Silodosin (SLD) is a novel α1-adrenoceptor antagonist which has shown promising clinical efficacy and safety in patients with benign prostatic hyperplasia (BPH). However, lack of information about metabolism of SLD prompted us to investigate metabolic fate of SLD in rats. To identify in vivo metabolites of SLD, urine, feces and plasma were collected from Sprague-Dawley rats after its oral administration. The samples were prepared using an optimized sample preparation approach involving protein precipitation followed by solid-phase extraction and then subjected to LC/HR-MS/MS analysis...
October 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/12566826/skin-penetration-and-sun-protection-factor-of-five-uv-filters-effect-of-the-vehicle
#2
COMPARATIVE STUDY
E Chatelain, B Gabard, C Surber
To gain information about efficacy and safety of sunscreens, we compared the skin penetration of ultraviolet (UV) filters from two vehicles, i.e. an oil-in-water (O/W) emulsion gel and petrolatum jelly both in vitro and in vivo, as well as the corresponding pharmacological effect, i.e. the sun protection factor (SPF) in vivo. The UV filters studied were benzophenone-3 (BPH), ethylhexyl methoxycinnamate (EHM), butyl methoxydibenzoyl methane, ethylhexyl salicylate and homosalate. The human skin penetration of these five chemicals from the two vehicles was determined both in vitro using Franz cells and in vivo using a standardized tape-stripping method...
January 2003: Skin Pharmacology and Applied Skin Physiology
https://www.readbyqxmd.com/read/12516962/multiplex-gene-expression-analysis-for-high-throughput-drug-discovery-screening-and-analysis-of-compounds-affecting-genes-overexpressed-in-cancer-cells
#3
Paul H Johnson, Roger P Walker, Steven W Jones, Kathy Stephens, Janet Meurer, Deborah A Zajchowski, May M Luke, Frank Eeckman, Yuping Tan, Linda Wong, Gordon Parry, Thomas K Morgan, Meg A McCarrick, Joseph Monforte
Drug discovery strategies are needed that can rapidly exploit multiple therapeutic targets associated with the complex gene expression changes that characterize a polygenic disease such as cancer. We report a new cell-based high-throughput technology for screening chemical libraries against several potential cancer target genes in parallel. Multiplex gene expression (MGE) analysis provides direct and quantitative measurement of multiple endogenous mRNAs using a multiplexed detection system coupled to reverse transcription-PCR...
December 2002: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/10720742/assessing-the-aquatic-toxicity-of-complex-hydrocarbon-mixtures-using-solid-phase-microextraction
#4
REVIEW
T F Parkerton, M A Stone, D J Letinski
Assessing the ecotoxicity of hydrocarbon mixtures is complicated by the complex nature of these mixtures. Traditional analytical methods for characterizing hydrocarbon contamination are not good predictors of potential ecotoxicity because these methods fail to characterize the bioavailability of individual hydrocarbon components. Recent research indicates that hydrocarbons act by a common narcotic mode of action and that ecotoxicity occurs when the molar concentration in organism lipid exceeds a critical threshold...
March 15, 2000: Toxicology Letters
https://www.readbyqxmd.com/read/9972474/mixed-function-oxidase-induction-in-carcinus-aestuarii-field-and-experimental-studies-for-the-evaluation-of-toxicological-risk-due-to-mediterranean-contaminants
#5
M C Fossi, C Savelli, S Casini
The aim of this study was to test and validate the use of mixed function oxidase (MFO) induction, in the crab Carcinus aestuarii, under experimental and field studies, for the evaluation of toxicological risk due to the main contaminants in the Mediterranean. Two different experiments were performed in the laboratory in order to identify the most suitable tissues for MFO studies in this species and the most suitable and sensitive MFO responses for evaluating chemical stress due to lipophilic contaminants. In order to validate this methodology in the field, two studies were carried out in two polluted Mediterranean lagoons: a transplant experiment in Orbetello Lagoon and an in situ experiment in Venice Lagoon...
November 1998: Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology
https://www.readbyqxmd.com/read/9653759/in-situ-salt-screening-a-useful-technique-for-discovery-support-and-preformulation-studies
#6
W Q Tong, G Whitesell
The purpose of this paper was to present an in situ salt screening technique which is applicable to most basic compounds. The theoretical aspects, experimental details, applications, and significance of this technique are illustrated through in situ salt screening studies performed on GW1818, an alpha 1A andrenergic receptor antagonist intended for treatment of benign prostatic hyperplasia (BPH). Generally, the in situ salt screening technique includes (i) acid selection, (ii) a solubility study, (iii) characterization of residual solids, and (iv) calculation of the Ksp and solubility of the salts...
May 1998: Pharmaceutical Development and Technology
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