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https://www.readbyqxmd.com/read/29225839/a-case-of-empyema-and-septic-arthritis-due-to-nocardia-farcinica
#1
Takashi Ishiguro, Hiroaki Yoshioka, Shoko Kawai, Shin-Ichi Katsumata, Tohru Gonoi, Noboru Takayanagi
Septic arthritis due to Nocardia sp. should be suspected when a patient with risk factors such as pneumoconiosis or diabetes mellitus develops joint symptoms, especially if the patient has had nocardiosis in other sites.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29218102/dexmedetomidine-alleviates-lps-induced-septic-cardiomyopathy-via-the-cholinergic-anti-inflammatory-pathway-in-mice
#2
Weilan Kong, Kai Kang, Yang Gao, Haitao Liu, Xianglin Meng, Songliu Yang, Kaijiang Yu, Mingyan Zhao
This study was conducted to investigate the role of the cholinergic anti-inflammatory pathway in LPS-induced septic cardiomyopathy in mice. C57BL/6 mice were used to construct septic cardiomyopathy models. The optimal duration of lipopolysaccharide (LPS) treatment was determined by HE staining and TUNEL assay. Blank controls were intraperitoneally injected with saline and models were injected with LPS (10 mg/kg) (LPS), α-bungarotoxin (BT-LPS), BT and dexmedetomidine (BT-DEX-LPS). The pathological examinations were performed on HE- stained myocardium tissues, apoptosis was determined using TUNEL assay, mRNA expression of NF-κB p65, Caspase-3, Caspase-8, Bcl-2, Bax, p53 and α7nACh was quantified using qRT-PCR, protein levels of IL-6, IL-1β, TNF-α and phosphorylated STAT3 (p-STAT3) were analyzed using Western blot analysis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29215382/initial-treatment-in-septic-arthritis-medical-versus-surgical-approach-an-8-year-single-center-in-spain-experience
#3
Bryan Josué Flores-Robles, Mercedes Jiménez Palop, Abel Alejandro Sanabria Sanchinel, Robert Francis Andrus, Ana Royuela Vicente, Marta Isabel Sanz Pérez, María Espinosa Malpartida, Consuelo Ramos Giráldez, Carolina Merino Argumanez, Luis Fernando Villa Alcázar, José Luis Andréu Sánchez, Hildegarda Godoy Tundidor, José Campos Esteban, Jesús Sanz Sanz, Carmen Barbadillo Mateos, Carlos Isasi Zaragoza, Juan Mulero Mendoza
OBJECTIVE: The aim of this study was to compare the functional results of 2 different procedure types, medical or surgical, which are used in treating native joint septic arthritis. METHODS: In this retrospective cohort study, we reviewed clinical registries of patients admitted to a single third-level hospital with the diagnosis of septic arthritis during the period of January 1, 2008, to January 31, 2016. RESULTS: A total of 63 cases of septic arthritis were identified in which the initial approach for 49 patients was medical (arthrocentesis), whereas the initial approach for 14 patients was surgical (arthroscopy or arthrotomy)...
December 5, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29189591/luc-s-abscess-and-temporomandibular-joint-septic-arthritis-two-rare-sequelae-of-acute-otitis-media
#4
Carmelle Tsai, Jennifer Deramo, Xiaofan Shen, Kathleen Vandiver, Vineeta Mittal
A 5-year-old previously healthy child presented with right-sided otalgia, right facial and temporal swelling, and right jaw pain in the setting of 6 days of low-grade fever. The child had no trauma, vomiting, or prior dental treatments. On physical examination, the patient had facial swelling, erythema, and tenderness over the right temporal region along with trismus, as well as pain on palpation of the right temporomandibular joint (TMJ). A computed tomography scan revealed otitis media, Luc's abscess, and TMJ septic arthritis requiring surgical drainage and intravenous antibiotics...
November 20, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29187561/a-real-pain-diagnostic-quandaries-and-septic-arthritis
#5
Cristina Costales, Susan M Butler-Wu
Rapid diagnosis and treatment of an infected joint is paramount in preserving orthopedic function. Here, we present a brief review of the many challenges associated with the diagnosis of both septic arthritis and prosthetic joint infections. We will also discuss the many laboratory tests currently available to aid in accurate diagnosis of joint infection as well as emerging diagnostics that may have future utility in the diagnosis of these challenging clinical entities.
November 29, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29185277/mri-findings-of-the-sacroiliac-joints-in-patients-with-low-back-pain-alternative-diagnosis-to-inflammatory-sacroiliitis
#6
Iris Eshed, Merav Lidar
BACKGROUND: Magnetic resonance imaging (MRI) is the most sensitive imaging modality for the detection of sacroiliitis. Diagnosing sacroiliitis on MRI is not always straightforward and can be challenging in some cases. OBJECTIVES: To evaluate the prevalence of alternative diagnoses suggested by MRI and characterize the MR appearance of the most common ones. METHODS: Consecutive MRI examinations of the sacroiliac joints (SIJ) performed between 2005 and 2012 were retrospectively evaluated for the presence of structural and active sacroiliitis findings according to the Assessment of SpondyloArthritis International Society guidelines...
November 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29168180/cxcr2-is-critical-for-bacterial-control-and-development-of-joint-damage-and-pain-in-staphylococcus-aureus-induced-septic-arthritis-in-mouse
#7
Daiane Boff, Vivian L S Oliveira, Celso M Queiroz Junior, Tarcília A Silva, Marcelo Allegretti, Waldiceu A Verri, Paul Proost, Mauro M Teixeira, Flavio A Amaral
Staphylococcus aureus is the main pathogen associated with septic arthritis. Upon infection, neutrophils are quickly recruited to the joint by different chemoattractants, especially CXCR1/2 binding chemokines. Although their excessive accumulation is associated with intense pain and permanent articular damage, neutrophils have an important function in controlling bacterial burden. This work aimed to study the role of CXCR2 in the control of infection, hypernociception and tissue damage in S. aureus-induced septic arthritis in mice...
November 22, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29164082/acute-septic-arthritis-of-the-knee-caused-by-kingella-kingae-in-a-5-year-old-cameroonian-boy
#8
Nawal El Houmami, Dimitri Ceroni, Karine Codjo Seignon, Jean-Christophe Pons, Cédric Lambert, Guillaume André Durand, Philippe Minodier, Léopold Lamah, Philippe Bidet, Jacques Schrenzel, Didier Raoult, Pierre-Edouard Fournier
Kingella kingae is an important cause of invasive infections in young children from Western countries. Although increasing reports indicate that this organism is the leading agent of bone and joint infections in early childhood, data on K. kingae infections from resource-limited settings are scarce, and none has yet been reported in Africa. We herein report the diagnostic and epidemiological investigations of the first case of K. kingae arthritis identified in a child from sub-Saharan Africa. A 5-year-old Cameroonian boy presented with a sudden painful limp which appeared in the course of a mild rhinopharyngitis...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29141929/septic-arthritis-of-knee-joint-due-to-parvimonas-micra
#9
Moni Roy, Ashish Kumar Roy, Sharjeel Ahmad
Parvimonas species are anaerobic, Gram-positive cocci that are a constituent of normal oral and gastrointestinal flora. We present a case of right knee joint septic arthritis due to Parvimonas micra in an immunocompromised patient. A 61-year-old male renal and pancreatic transplant recipient on immunosuppressive therapy was admitted to our hospital due to intense pain, joint swelling and inability to move his right knee over the past 9 months. After synovial fluid was drawn, cultures were positive for P. micra, an anaerobic pathogen that is part of the flora of the oral cavity...
November 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29132347/knee-arthrodesis-versus-above-the-knee-amputation-after-septic-failure-of-revision-total-knee-arthroplasty-comparison-of-functional-outcome-and-complication-rates
#10
Sven Hungerer, Martin Kiechle, Christian von Rüden, Matthias Militz, Knut Beitzel, Mario Morgenstern
BACKGROUND: After septic failure of total knee arthroplasty (TKA) and multiple revision operations resulting in impaired function, bone and/or soft-tissue damage a reconstruction with a revision arthroplasty might be impossible. Salvage procedures to regain mobility and quality of life are an above-the-knee amputation or knee arthrodesis. The decision process for the patient and surgeon is difficult and data comparing arthrodesis versus amputation in terms of function and quality of life are scarce...
November 13, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29130010/spontaneous-bilateral-sternoclavicular-joint-septic-arthritis-and-lumbar-discitis-an-unusual-case-in-a-healthy-adult
#11
Georgios Mamarelis, Mohammad Zain Sohail, Athanasios Mamarelis, Hassan Fawi, Jehangir Mahaluxmivala
Introduction: Septic arthritis of the sternoclavicular (SC) joint is a rare condition. Typically, it presents in patients with risk of infection and is usually unilateral. In this report, we describe a case of spontaneous bilateral sternoclavicular joint infection of an otherwise healthy adult. Case Presentation: A 67-year-old man presented in our hospital complaining of 2-week history of neck and chest pain which was radiating to his shoulders bilaterally. Clinical examination revealed erythema and swelling of the sternoclavicular area...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29123565/lemierre-s-syndrome-a-rare-cause-of-disseminated-sepsis-requiring-multi-organ-support
#12
John Rae, Katie Misselbrook
Lemierre's syndrome is a rare complication of acute pharyngitis characterised by septicaemia with infective thrombophlebitis of the internal jugular vein, most commonly due to Fusobacterium necrophorum. It characteristically affects healthy young adults causing persistent pyrexia and systemic sepsis presenting several days after an initial pharyngitis. Septic emboli seed via the bloodstream to distant sites including the lung, joints, skin, liver, spleen and brain. Prolonged antimicrobial therapy is required and admission to intensive care common...
November 2017: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/29099890/the-role-of-synovial-cytokines-in-the-diagnosis-of-periprosthetic-joint-infections-current-concepts
#13
Jared M Newman, Jaiben George, Alison K Klika, Wael K Barsoum, Carlos A Higuera
Periprosthetic joint infection (PJI) is a serious and potentially devastating complication of total joint arthroplasty. Accurate diagnosis of PJI is of utmost importance, but differentiating septic from aseptic failed total joint arthroplasty is extremely challenging, and improper management can lead to significant morbidity. The gold standard for PJI diagnosis is based on standardized laboratory and clinical criteria but relies on preoperative and intraoperative findings, which can be unreliable. Given these limitations, research has focused on new methods for diagnosing PJI...
September 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29096980/arthroscopic-management-of-septic-arthritis-of-the-native-shoulder-a-systematic-review
#14
REVIEW
Muzammil Memon, Jeffrey Kay, Lydia Ginsberg, Darren de Sa, Nicole Simunovic, Kristian Samuelsson, George S Athwal, Olufemi R Ayeni
PURPOSE: To investigate arthroscopic management of native shoulder joint septic arthritis-specifically, indications, patient outcomes, and complications. METHODS: PubMed, MEDLINE, and Embase were used to search the literature, and data abstraction was performed independently and in duplicate. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist guided reporting and data abstraction. The quality of all included studies was assessed with the Methodological Index for Non-randomized Studies (MINORS) criteria...
October 30, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29081854/toxic-shock-in-children-with-bone-and-joint-infections-a-review-of-seven-years-of-patients-admitted-to-one-intensive-care-unit
#15
D L Kerr, E K Loraas, A C Links, T V Brogan, G A Schmale
PURPOSE: The objective of this study was to compare the frequency of severe systemic, multi-organ involvement and toxic shock syndrome (TSS) in patients with Staphylococcus aureus (SA) and Group A β-haemolytic Streptococcus pyogenes (GABS) bone and joint infections. METHODS: We retrospectively reviewed patients treated for septic arthritis or osteomyelitis at one children's hospital between 2002 and 2009. The rates of intensive care unit (ICU) admission for methicillin-sensitive SA (MSSA), methicillin-resistant SA (MRSA) and GABS infections were compared, as were the lengths of stay, number of surgeries, operative procedures and cases of TSS...
October 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29079156/septic-arthritis-and-prosthetic-joint-infections-in-older-adults
#16
REVIEW
Rajeshwari Nair, Marin L Schweizer, Namrata Singh
Older adults are at increased risk for septic arthritis and prosthetic joint infections (PJI), owing at least in part to comorbid conditions and frailty. An increasing number of older adults undergo total joint arthroplasty to improve their quality of life. Infections in older adults differ from younger populations by the causative organisms, a great proportion of which are Staphylococcal infections. Targeting important modifiable and nonmodifiable risk factors may prevent or reduce the burden of joint infections in older adults...
December 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29079067/clinical-mimics-an-emergency-medicine-focused-review-of-cellulitis-mimics
#17
Garrett Blumberg, Brit Long, Alex Koyfman
BACKGROUND: Cellulitis is a common clinical condition with low rates of morbidity and mortality if treated appropriately. Mimics of cellulitis presenting with erythema, edema, warmth, and pain can be associated with grave morbidity and mortality if misdiagnosed. OBJECTIVE: This review investigates the signs and symptoms of cellulitis, mimics of cellulitis, and an approach to the management of both cellulitis and its mimics. DISCUSSION: The current emergency medicine definition of cellulitis includes erythema, induration, warmth, and swelling...
October 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29074430/role-of-th17-and-treg-cells-in-septic-arthritis-and-the-impact-of-the-th17-treg-derived-cytokines-in-the-pathogenesis-of-s-aureus-induced-septic-arthritis-in-mice
#18
Ipsita Dey, Biswadev Bishayi
Intravenous inoculation of Swiss mice with S. aureus leads to severe synovial joint tissue swelling along with prominent T lymphocyte infiltrate with associated inflammation in synovial tissue. Cytokines released from macrophages such as TNF-α, IL-1β and IL-6 the main players that precede cartilage and bone destruction during septic arthritis (SA) followed by osteoclast differentiation and bone resorption. CD4+ naïve T cells upon cytokine driven activation, differentiate into lineages of helper (Th) and regulatory T cells (Treg) including inflammatory Th17 cell lineage...
October 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29071046/native-join-propionibacterium-septic-arthritis
#19
Thomas Taylor, Marcus Coe, Ana Mata-Fink, Richard Zuckerman
Propionibacterium species are associated with normal skin flora and cultures may be dismissed as contaminants. They are increasingly recognized as a cause of septic arthritis following shoulder arthroplasty and arthrotomy. We identified three cases of Propionibacterium septic arthritis in native joints mimicking atypical osteoarthritis and review the literature, clinical course, and treatment of 18 cases. Two cases of Propionibacterium acne in native knee joints and one in a sternoclavicular joint are described...
October 2, 2017: Infectious Disease Reports
https://www.readbyqxmd.com/read/29067626/the-influence-of-antibiotic-loaded-cement-spacers-on-the-risk-of-reinfection-after-septic-two-stage-hip-revision-surgery
#20
Kevin Staats, Florian Sevelda, Alexandra Kaider, Christoph Böhler, Irene K Sigmund, Stephan E Puchner, Reinhard Windhager, Johannes Holinka
PURPOSE: The aim of this study was the evaluation of possible outcome differences of patients undergoing two-stage hip exchange with antibiotic-loaded spacers, compared to patients without an interim spacer implantation. METHODS: We evaluated 46 patients undergoing two-stage hip revision surgery. Twenty-five patients received an interim ALS. Additional to a Kaplan-Meier survival analysis, a competing risk analysis was performed to estimate the cumulative incidence function for re-revisions due to infection accounting for death as a competing event...
October 24, 2017: Infection
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