keyword
MENU ▼
Read by QxMD icon Read
search

randomised

keyword
https://www.readbyqxmd.com/read/29656569/ghanaian-parents-perceptions-of-pre-and-postnatal-nutrient-supplements-and-their-effects
#1
Katherine P Adams, Harriet Okronipa, Seth Adu-Afarwuah, Mary Arimond, Sika Kumordzie, Brietta M Oaks, Maku E Ocansey, Rebecca R Young, Stephen A Vosti, Kathryn G Dewey
Small-quantity lipid-based nutrient supplements (SQ-LNS) have been studied in efficacy and effectiveness trials, but little is known about how parents perceive the products and their effects. In a randomised trial in Ghana, efficacy of SQ-LNS provided to women during pregnancy and the first 6 months postpartum and to their children from 6 to 18 months of age was assessed by comparison with iron-folic acid (IFA) capsules and multiple micronutrient (MMN) capsules provided to women. In a follow-up study conducted when the index children from the original trial were between 4 and 6 years of age, we used survey-based methods to assess retrospective and current parental perceptions of nutrient supplements generally and of SQ-LNS and their effects compared with perceptions IFA and MMN capsules...
April 15, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29656301/septoplasty-for-nasal-obstruction-due-to-a-deviated-nasal-septum-in-adults-a-systematic-review
#2
M M H T van Egmond, M M Rovers, A H J Tillema, N van Heerbeek
BACKGROUND: The status of current evidence for the effectiveness of septoplasty is unclear. This systematic review evaluates the effectiveness of a) septoplasty (with or without concurrent turbinate surgery) versus non-surgical management, and b) septoplasty with concurrent turbinate surgery versus septoplasty alone, for nasal obstruction due to a deviated nasal septum in adults. METHODOLOGY: Eligible for inclusion were randomised controlled trials and non-randomised designs comparing treatment strategies...
April 15, 2018: Rhinology
https://www.readbyqxmd.com/read/29656206/enhancing-first-time-parents-self-efficacy-a-systematic-review-and-meta-analysis-of-universal-parent-education-interventions-efficacy
#3
REVIEW
Nur Arina Liyana Amin, Wilson W S Tam, Shefaly Shorey
BACKGROUND: Poor adjustment during early parenthood often leads to low feelings of parental self-efficacy, which influences parents' behaviours towards their infants. The long-term consequences on infant development warrant the need for more attention on the efficacy of universal parent education interventions to empower parents and enhance their self-efficacy. OBJECTIVES: To synthesise available evidence and explore the efficacy of universal parent education interventions on the parental self-efficacy of first-time parents...
March 28, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29656129/no-difference-in-implant-survivorship-and-clinical-outcomes-between-full-cementless-and-full-cemented-fixation-in-primary-total-knee-arthroplasty-a-systematic-review-and-meta-analysis
#4
REVIEW
Kai Zhou, Haoda Yu, Jinglong Li, Haoyang Wang, Zongke Zhou, Fuxing Pei
BACKGROUND: The debate over the use of cemented or cementless fixation in total knee arthroplasty (TKA) has never stopped since cementless fixation was introduced. We undertook a systematic review and meta-analysis to evaluate the optimal mode of fixation (full-cementless vs. full-cemented) in TKA. METHODS: PubMed, Embase, and the Cochrane Library databases up to July 2017 were searched to identify randomised controlled trials (RCTs) and quasi-RCTs comparing full-cementless TKA and full-cemented TKA...
April 12, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29655877/endocrine-and-haemodynamic-changes-in-resistant-hypertension-and-blood-pressure-responses-to-spironolactone-or-amiloride-the-pathway-2-mechanisms-substudies
#5
Bryan Williams, Thomas M MacDonald, Steve V Morant, David J Webb, Peter Sever, Gordon T McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Sandosh Padmanabhan, Isla S Mackenzie, Jackie Salsbury, Morris J Brown
BACKGROUND: In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess the mechanisms underlying this superiority and the pathogenesis of resistant hypertension. METHODS: PATHWAY-2 was a randomised, double-blind crossover trial done at 14 UK primary and secondary care sites in 314 patients with resistant hypertension. Patients were given 12 weeks of once daily treatment with each of placebo, spironolactone 25-50 mg, bisoprolol 5-10 mg, and doxazosin 4-8 mg and the change in home systolic blood pressure was assessed as the primary outcome...
April 11, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29655496/effectiveness-of-a-long-lasting-piperonyl-butoxide-treated-insecticidal-net-and-indoor-residual-spray-interventions-separately-and-together-against-malaria-transmitted-by-pyrethroid-resistant-mosquitoes-a-cluster-randomised-controlled-two-by-two-factorial-design
#6
Natacha Protopopoff, Jacklin F Mosha, Eliud Lukole, Jacques D Charlwood, Alexandra Wright, Charles D Mwalimu, Alphaxard Manjurano, Franklin W Mosha, William Kisinza, Immo Kleinschmidt, Mark Rowland
BACKGROUND: Progress in malaria control is under threat by wide-scale insecticide resistance in malaria vectors. Two recent vector control products have been developed: a long-lasting insecticidal net that incorporates a synergist piperonyl butoxide (PBO) and a long-lasting indoor residual spraying formulation of the insecticide pirimiphos-methyl. We evaluated the effectiveness of PBO long-lasting insecticidal nets versus standard long-lasting insecticidal nets as single interventions and in combination with the indoor residual spraying of pirimiphos-methyl...
April 11, 2018: Lancet
https://www.readbyqxmd.com/read/29655378/mindfulness-based-cognitive-therapy-v-treatment-as-usual-in-adults-with-adhd-a-multicentre-single-blind-randomised-controlled-trial-erratum
#7
Lotte Janssen, Cornelis C Kan, Pieter J Carpentier, Bram Sizoo, Sevket Hepark, Melanie P J Schellekens, A Rogier T Donders, Jan K Buitelaar, Anne E M Speckens
No abstract text is available yet for this article.
April 15, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29652929/immunogenicity-and-safety-of-three-consecutive-production-lots-of-the-non-replicating-smallpox-vaccine-mva-a-randomised-double-blind-placebo-controlled-phase-iii-trial
#8
Edgar Turner Overton, Steven J Lawrence, Eva Wagner, Katrin Nopora, Siegfried Rösch, Philip Young, Darja Schmidt, Christian Kreusel, Sonja De Carli, Thomas P Meyer, Heinz Weidenthaler, Nathaly Samy, Paul Chaplin
BACKGROUND: Modified Vaccinia Ankara (MVA) is a live, viral vaccine under advanced development as a non-replicating smallpox vaccine. A randomised, double-blind, placebo-controlled phase III clinical trial was conducted to demonstrate the humoral immunogenic equivalence of three consecutively manufactured MVA production lots, and to confirm the safety and tolerability of MVA focusing on cardiac readouts. METHODS: The trial was conducted at 34 sites in the US. Vaccinia-naïve adults aged 18-40 years were randomly allocated to one of four groups using a 1:1:1:1 randomization scheme...
2018: PloS One
https://www.readbyqxmd.com/read/29652246/metformin-in-non-diabetic-hyperglycaemia-the-glint-feasibility-rct
#9
Simon J Griffin, M Angelyn Bethel, Rury R Holman, Kamlesh Khunti, Nicholas Wareham, Gwen Brierley, Melanie Davies, Andrew Dymond, Rose Eichenberger, Philip Evans, Alastair Gray, Colin Greaves, Kyla Harrington, Graham Hitman, Greg Irving, Sarah Lessels, Ann Millward, John R Petrie, Martin Rutter, Mike Sampson, Naveed Sattar, Stephen Sharp
BACKGROUND: The treatment of people with diabetes with metformin can reduce cardiovascular disease (CVD) and may reduce the risk of cancer. However, it is unknown whether or not metformin can reduce the risk of these outcomes in people with elevated blood glucose levels below the threshold for diabetes [i.e. non-diabetic hyperglycaemia (NDH)]. OBJECTIVE: To assess the feasibility of the Glucose Lowering In Non-diabetic hyperglycaemia Trial (GLINT) and to estimate the key parameters to inform the design of the full trial...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29652088/non-invasive-brain-stimulation-techniques-for-chronic-pain
#10
REVIEW
Neil E O'Connell, Louise Marston, Sally Spencer, Lorraine H DeSouza, Benedict M Wand
BACKGROUND: This is an updated version of the original Cochrane Review published in 2010, Issue 9, and last updated in 2014, Issue 4. Non-invasive brain stimulation techniques aim to induce an electrical stimulation of the brain in an attempt to reduce chronic pain by directly altering brain activity. They include repetitive transcranial magnetic stimulation (rTMS), cranial electrotherapy stimulation (CES), transcranial direct current stimulation (tDCS), transcranial random noise stimulation (tRNS) and reduced impedance non-invasive cortical electrostimulation (RINCE)...
April 13, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29651981/lamotrigine-for-people-with-borderline-personality-disorder-a-rct
#11
Mike J Crawford, Rahil Sanatinia, Barbara Barrett, Gillian Cunningham, Oliver Dale, Poushali Ganguli, Geoff Lawrence-Smith, Verity C Leeson, Fenella Lemonsky, Georgia Lykomitrou-Matthews, Alan Montgomery, Richard Morriss, Jasna Munjiza, Carol Paton, Iwona Skorodzien, Vineet Singh, Wei Tan, Peter Tyrer, Joseph G Reilly
BACKGROUND: No drug treatments are currently licensed for the treatment of borderline personality disorder (BPD). Despite this, people with this condition are frequently prescribed psychotropic medications and often with considerable polypharmacy. Preliminary studies have indicated that mood stabilisers may be of benefit to people with BPD. OBJECTIVE: To examine the clinical effectiveness and cost-effectiveness of lamotrigine for people with BPD. DESIGN: A two-arm, double-blind, placebo-controlled individually randomised trial of lamotrigine versus placebo...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29651888/mechanisms-of-performance-improvements-due-to-a-leading-teammate-during-uphill-cycling
#12
Theo Ouvrard, Alain Groslambert, Gilles Ravier, Sidney Grosprêtre, Phillipe Gimenez, Frederic Grappe
PURPOSE: This study aimed to identify the impact of a leading teammate in front of a cyclist on psychological, physiological, biomechanical and performance parameters during an uphill maximal effort. METHODS: After familiarisation, twelve well-trained competitive cyclists completed two uphill time-trials (UTTs, 2.7 km at 7.4 %) in randomised order: one performed alone (control condition), and one following a simulated teammate during the entire UTT (leader condition)...
April 13, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29651778/cost-consequence-analysis-alongside-a-randomised-controlled-trial-of-hospital-versus-telephone-follow-up-after-treatment-for-endometrial-cancer
#13
Padraig Dixon, Kinta Beaver, Susan Williamson, Chris Sutton, Pierre Martin-Hirsch, William Hollingworth
BACKGROUND: Regular outpatient follow-up programmes are usually offered to patients following treatment for gynaecological and other cancers. Despite the substantial resources involved in providing these programmes, there is evidence that routine follow-up programmes do not affect survival or the likelihood of detecting recurrence and may not meet patient needs. Alternative follow-up modalities may offer the same outcomes at lower cost. We examined the costs of using telephone-based routine follow-up of women treated for endometrial cancer undertaken by specialist gynaecology oncology nurses in comparison to routine hospital-based follow-up...
April 12, 2018: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29650644/correction-repeated-administration-of-dapirolizumab-pegol-in-a-randomised-phase-i-study-is-well-tolerated-and-accompanied-by-improvements-in-several-composite-measures-of-systemic-lupus-erythematosus-disease-activity-and-changes-in-whole-blood-transcriptomic
#14
https://www.readbyqxmd.com/read/29650559/care-in-chronic-obstructive-lung-disease-carol-a-randomised-trial-in-general-practice
#15
Stefan Markun, Thomas Rosemann, Kaba Dalla-Lana, Claudia Steurer-Stey
Background: Disease management of chronic obstructive pulmonary disease (COPD) is complex and shortcomings in general practice care for COPD are common. A care bundle is a disease management aid reminding and steering specific elements of care. Objectives: To test whether a COPD care bundle delivered to general practitioners (GPs) and practice assistants (PAs) increases the implementation of key elements of COPD care. Methods: Cluster-randomised clinical trial, 1:1 randomisation of GPs, one-year follow-up. The intervention introduced a COPD care bundle and aimed at enhancing collaboration between GPs and PAs...
April 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29650475/use-of-patient-reported-outcome-measures-in-oral-and-maxillofacial-trauma-surgery-a-review
#16
REVIEW
R Ologunde, N M H McLeod
In the UK, about one person/100/year sustains a facial injury, so trauma surgery accounts for a considerable part of the caseload in oral and maxillofacial surgery (OMFS). Patient-reported outcome measures (PROM) allow for patient-centred assessment of postoperative outcomes, but to our knowledge, most research in OMFS trauma does not currently include them. To investigate their use, we searched Medline to find relevant studies that reported outcomes from inception in January 1879 to August 2016. Those not in the English language and those that did not report operations were excluded...
April 9, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29650408/normothermic-ex-vivo-preservation-with-the-portable-organ-care-system-lung-device-for-bilateral-lung-transplantation-inspire-a-randomised-open-label-non-inferiority-phase-3-study
#17
Gregor Warnecke, Dirk Van Raemdonck, Michael A Smith, Gilbert Massard, Jasleen Kukreja, Federico Rea, Gabriel Loor, Fabio De Robertis, Jayan Nagendran, Kumud K Dhital, Francisco Javier Moradiellos Díez, Christoph Knosalla, Christian A Bermudez, Steven Tsui, Kenneth McCurry, I-Wen Wang, Tobias Deuse, Guy Lesèche, Pascal Thomas, Igor Tudorache, Christian Kühn, Murat Avsar, Bettina Wiegmann, Wiebke Sommer, Arne Neyrinck, Marco Schiavon, Fiorella Calebrese, Nichola Santelmo, Anne Olland, Pierre-Emanuel Falcoz, Andre R Simon, Andres Varela, Joren C Madsen, Marshall Hertz, Axel Haverich, Abbas Ardehali
BACKGROUND: Severe primary graft dysfunction (PGD) of grade 3 (PGD3) is a common serious complication following lung transplantation. We aimed to assess physiological donor lung preservation using the Organ Care System (OCS) Lung device compared with cold static storage. METHODS: In this non-inferiority, randomised, controlled, open-label, phase 3 trial (INSPIRE) recipients were aged 18 years or older and were registered as standard criteria primary double lung transplant candidates...
April 9, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29650363/chemotherapy-versus-chemoradiotherapy-after-surgery-and-preoperative-chemotherapy-for-resectable-gastric-cancer-critics-an-international-open-label-randomised-phase-3-trial
#18
Annemieke Cats, Edwin P M Jansen, Nicole C T van Grieken, Karolina Sikorska, Pehr Lind, Marianne Nordsmark, Elma Meershoek-Klein Kranenbarg, Henk Boot, Anouk K Trip, H A Maurits Swellengrebel, Hanneke W M van Laarhoven, Hein Putter, Johanna W van Sandick, Mark I van Berge Henegouwen, Henk H Hartgrink, Harm van Tinteren, Cornelis J H van de Velde, Marcel Verheij
BACKGROUND: Both perioperative chemotherapy and postoperative chemoradiotherapy improve survival in patients with resectable gastric cancer from Europe and North America. To our knowledge, these treatment strategies have not been investigated in a head to head comparison. We aimed to compare perioperative chemotherapy with preoperative chemotherapy and postoperative chemoradiotherapy in patients with resectable gastric adenocarcinoma. METHODS: In this investigator-initiated, open-label, randomised phase 3 trial, we enrolled patients aged 18 years or older who had stage IB- IVA resectable gastric or gastro-oesophageal adenocarcinoma (as defined by the American Joint Committee on Cancer, sixth edition), with a WHO performance status of 0 or 1, and adequate cardiac, bone marrow, liver, and kidney function...
April 9, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29650336/acute-physiological-responses-to-low-intensity-blood-flow-restriction-cycling
#19
H J Thomas, B R Scott, J J Peiffer
OBJECTIVES: Blood flow restriction (BFR) during interval cycling may stimulate aerobic and anaerobic adaptations. However, acute physiological responses to BFR interval cycling have not been extensively investigated. DESIGN: Eighteen males completed low-intensity (LI), low-intensity with BFR (LIBFR ) and high-intensity (HI) interval cycling sessions in randomised and counterbalanced order. These included a standardised warm-up and three two-min intervals interspersed with two-min recovery...
April 9, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29650060/gastrostomy-versus-nasogastric-tube-feeding-for-chemoradiation-patients-with-head-and-neck-cancer-the-tube-pilot-rct
#20
Vinidh Paleri, Joanne Patterson, Nikki Rousseau, Eoin Moloney, Dawn Craig, Dimitrios Tzelis, Nina Wilkinson, Jeremy Franks, Ann Marie Hynes, Ben Heaven, David Hamilton, Teresa Guerrero-Urbano, Rachael Donnelly, Stewart Barclay, Tim Rapley, Deborah Stocken
BACKGROUND: Approximately 9000 new cases of head and neck squamous cell cancers (HNSCCs) are treated by the NHS each year. Chemoradiation therapy (CRT) is a commonly used treatment for advanced HNSCC. Approximately 90% of patients undergoing CRT require nutritional support via gastrostomy or nasogastric tube feeding. Long-term dysphagia following CRT is a primary concern for patients. The effect of enteral feeding routes on swallowing function is not well understood, and the two feeding methods have, to date (at the time of writing), not been compared...
April 2018: Health Technology Assessment: HTA
keyword
keyword
77331
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"