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https://www.readbyqxmd.com/read/29053911/investigating-the-minimal-clinically-important-difference-for-snot-22-symptom-domains-in-surgically-managed-chronic-rhinosinusitis
#1
Naweed I Chowdhury, Jess C Mace, Todd E Bodner, Jeremiah A Alt, Adam S Deconde, Joshua M Levy, Timothy L Smith
BACKGROUND: Prior work has described 5 domains within the 22-item Sino-Nasal Outcomes Test (SNOT-22) that allow for stratification of symptoms into similar clusters and that can be used to direct therapy. Although the outcomes of various interventions on these symptom domains have been reported, minimal clinically important difference (MCID) values have not been investigated, which has limited clinical interpretation of these results. METHODS: This study was designed as a secondary analysis of a prospective, multi-institutional, observational cohort...
October 20, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29053875/current-state-of-the-surgical-treatment-of-terminal-neuromas
#2
Graham C Ives, Theodore A Kung, Bao Tram Nghiem, Daniel C Ursu, David L Brown, Paul S Cederna, Stephen W P Kemp
Painful terminal neuromas resulting from nerve injury following amputation are common. However, there is currently no universally accepted gold standard of treatment for this condition. A comprehensive literature review is presented on the treatment of terminal neuromas. Four categories of terminal neuroma surgical procedures are assessed: epineurial closure; nerve transposition with implantation; neurorrhaphy, and alternate target reinnervation. Significant patient and case studies are highlighted in each section, focusing on surgical technique and patient outcome metrics...
October 19, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29052539/engineering-diagnostic-and-therapeutic-gut-bacteria
#3
Brian P Landry, Jeffrey J Tabor
Genetically engineered bacteria have the potential to diagnose and treat a wide range of diseases linked to the gastrointestinal tract, or gut. Such engineered microbes will be less expensive and invasive than current diagnostics and more effective and safe than current therapeutics. Recent advances in synthetic biology have dramatically improved the reliability with which bacteria can be engineered with the sensors, genetic circuits, and output (actuator) genes necessary for diagnostic and therapeutic functions...
October 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/29051825/continuous-glucose-monitoring-in-neonates-a-review
#4
REVIEW
Christopher J D McKinlay, J Geoffrey Chase, Jennifer Dickson, Deborah L Harris, Jane M Alsweiler, Jane E Harding
Continuous glucose monitoring (CGM) is well established in the management of diabetes mellitus, but its role in neonatal glycaemic control is less clear. CGM has provided important insights about neonatal glucose metabolism, and there is increasing interest in its clinical use, particularly in preterm neonates and in those in whom glucose control is difficult. Neonatal glucose instability, including hypoglycaemia and hyperglycaemia, has been associated with poorer neurodevelopment, and CGM offers the possibility of adjusting treatment in real time to account for individual metabolic requirements while reducing the number of blood tests required, potentially improving long-term outcomes...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29047710/intrinsic-decomposition-from-a-single-spectral-image
#5
Xi Chen, Weixin Zhu, Yang Zhao, Yao Yu, Yu Zhou, Tao Yue, Sidan Du, Xun Cao
In this paper, we present a spectral intrinsic image decomposition (SIID) model, which is dedicated to resolve a natural scene into its purely independent intrinsic components: illumination, shading, and reflectance. By introducing spectral information, our work can solve many challenging cases, such as scenes with metameric effects, which are hard to tackle for trichromatic intrinsic image decomposition (IID), and thus offers potential benefits to many higher-level vision tasks, e.g., materials classification and recognition, shape-from-shading, and spectral image relighting...
July 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29046222/a-social-network-analysis-of-the-goal-scoring-passing-networks-of-the-2016-european-football-championships
#6
Scott Mclean, Paul M Salmon, Adam D Gorman, Nicholas J Stevens, Colin Solomon
In the current study, social network analysis (SNA) and notational analysis (NA) methods were applied to examine the goal scoring passing networks (GSPN) for all goals scored at the 2016 European Football Championships. The aim of the study was to determine the GSPN characteristics for the overall tournament, between the group and knock out stages, and for the successful and unsuccessful teams. The study also used degree centrality (DC) metrics as a novel method to determine the relative contributions of the pitch locations involved in the GSPN...
October 16, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29044796/social-traits-social-networks-and-evolutionary-biology
#7
David N Fisher, Andrew G McAdam
The social environment is both an important agent of selection for most organisms, and an emergent property of their interactions. As an aggregation of interactions among members of a population, the social environment is a product of many sets of relationships, and so can be represented as a network or matrix. Social network analysis in animals has focused on why these networks possess the structure they do, and whether individuals' network traits, representing some aspect of their social phenotype, relate to their fitness...
October 17, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29043762/food-deserts-in-winnipeg-canada-a-novel-method-for-measuring-a-complex-and-contested-construct
#8
Joyce Slater, Stefan Epp-Koop, Megan Jakilazek, Chris Green
INTRODUCTION: "Food deserts" have emerged over the past 20 years as spaces of concern for communities, public health authorities and researchers because of their potential negative impact on dietary quality and subsequent health outcomes. Food deserts are residential geographic spaces, typically in urban settings, where low-income residents have limited or no access to retail food establishments with sufficient variety at affordable cost. Research on food deserts presents methodological challenges including retail food store identification and classification, identification of low-income populations, and transportation and proximity metrics...
October 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29043761/exploring-sales-data-during-a-healthy-corner-store-intervention-in-toronto-the-food-retail-environments-shaping-health-fresh-project
#9
Leia M Minaker, Meghan Lynch, Brian E Cook, Catherine L Mah
INTRODUCTION: Population health interventions in the retail food environment, such as corner store interventions, aim to influence the kind of cues consumers receive so that they are more often directed toward healthier options. Research that addresses financial aspects of retail interventions, particularly using outcome measures such as store sales that are central to retail decision making, is limited. This study explored store sales over time and across product categories during a healthy corner store intervention in a lowincome neighbourhood in Toronto, Ontario...
October 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29042854/influence-of-standard-laboratory-procedures-on-measures-of-erythrocyte-damage
#10
Lena Wiegmann, Diane A de Zélicourt, Oliver Speer, Alissa Muller, Jeroen S Goede, Burkhardt Seifert, Vartan Kurtcuoglu
The ability to characterize the mechanical properties of erythrocytes is important in clinical and research contexts: to diagnose and monitor hematologic disorders, as well as to optimize the design of cardiovascular implants and blood circulating devices with respect to blood damage. However, investigation of red blood cell (RBC) properties generally involves preparatory and processing steps. Even though these impose mechanical stresses on cells, little is known about their impact on the final measurement results...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29037963/conversion-between-noise-exposure-indicators-leq24h-lday-levening-lnight-ldn-and-lden-principles-and-practical-guidance
#11
Mark Brink, Beat Schäffer, Reto Pieren, Jean Marc Wunderli
This article presents empirically derived conversion rules between the environmental noise exposure metrics Leq24h, LDay, LEvening, LNight, Ldn, and Lden for the noise sources road, rail and air traffic. It caters to researchers that need to estimate the value of one (unknown) noise metric from the value of another (known) metric, e.g. in the scope of epidemiological meta-analyses or systematic reviews, when results from different studies are pooled and need to be related to one common exposure metric. Conversion terms are derived using two empirical methods a) based on analyzing the diurnal variation of traffic, and b) by analyzing differences between calculated noise exposure metrics...
October 9, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29037474/land-surface-phenology-what-do-we-really-see-from-space
#12
David Helman
Land surface phenology (LSP) provides bio-indication of ongoing climate change. It uses space-borne greenness proxies to monitor plant phenology at the landscape level from the regional to global scale. However, several unconsidered methodological and observational -related limitations may lead to misinterpretation of the satellite-derived signals. For instance, changes in species composition within a pixel could result in a change in the time series of the greenness proxy, due to the distinct phenology of the plant species involved...
October 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29036060/wave-optics-simulations-of-synthetic-aperture-ladar-performance-through-turbulence
#13
Bryce E Schumm, Matthew P Dierking
This paper utilizes a combination of theory and simulations to examine synthetic aperture imaging across a wide range of turbulence conditions. Extensive wave optics simulations are used to validate existing theory and to investigate the use of a common measurement technique. It demonstrates the applicability of earlier synthetic aperture laser radar (ladar) (SAL) research across a wide range of turbulence conditions, and examines the metric approaches and limitations for the imaging conditions normally seen in practical SAL systems...
October 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29034136/threshold-limit-graphical-approach-to-understanding-outcome-predictive-metrics-data-from-the-osteoarthritis-initiative
#14
John A Hipp, Elaine F Chan
Scatter plots, bar charts, linear regressions, analysis of variance, and other graphics and tests are frequently used to document associations between an independent variable and an outcome. However, these methods are also frequently limited when understanding how to use an independent variable in subsequent research or patient management. A novel graphical approach to visualizing data-the threshold limit graph-was therefore developed. Publically available data from the Osteoarthritis Initiative was used to illustrate the graphical approach to understanding the association between the change in joint space width (ΔJSW, independent variable) over four years, and knee symptoms at four years (using the Knee Injury and Osteoarthritis Outcome Score [KOOS], dependent variable)...
July 8, 2017: Curēus
https://www.readbyqxmd.com/read/29033881/age-and-gender-differences-in-facial-attractiveness-but-not-emotion-resemblance-contribute-to-age-and-gender-stereotypes
#15
Rocco Palumbo, Reginald B Adams, Ursula Hess, Robert E Kleck, Leslie Zebrowitz
Considerable research has shown effects of facial appearance on trait impressions and group stereotypes. We extended those findings in two studies that investigated the contribution of resemblance to emotion expressions and attractiveness to younger adults (YA) and older adults (OA) age and gender stereotypes on the dimensions of warmth and competence. Using connectionist modeling of facial metrics of 240 neutral younger and older faces, Study 1 found that, neutral expression older faces or female faces showed greater structural resemblance to happy expressions and less resemblance to angry expressions than did younger or male faces, respectively...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29033801/heavy-drinking-in-college-students-is-associated-with-accelerated-gray-matter-volumetric-decline-over-a-2-year-period
#16
Shashwath A Meda, Alecia D Dager, Keith A Hawkins, Howard Tennen, Sarah Raskin, Rebecca M Wood, Carol S Austad, Carolyn R Fallahi, Godfrey D Pearlson
Background: Heavy and/or harmful alcohol use while in college is a perennial and significant public health issue. Despite the plethora of cross-sectional research suggesting deleterious effects of alcohol on the brain, there is a lack of literature investigating the longitudinal effects of alcohol consumption on the adolescent brain. We aim to probe the longitudinal effects of college drinking on gray matter change in students during this crucial neurodevelopmental period. Methods: Data were derived from the longitudinal Brain and Alcohol Research in College Students (BARCS) study of whom a subset underwent brain MRI scans at two time points 24 months apart...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29033305/machine-learning-of-human-pluripotent-stem-cell-derived-engineered-cardiac-tissue-contractility-for-automated-drug-classification
#17
Eugene K Lee, David D Tran, Wendy Keung, Patrick Chan, Gabriel Wong, Camie W Chan, Kevin D Costa, Ronald A Li, Michelle Khine
Accurately predicting cardioactive effects of new molecular entities for therapeutics remains a daunting challenge. Immense research effort has been focused toward creating new screening platforms that utilize human pluripotent stem cell (hPSC)-derived cardiomyocytes and three-dimensional engineered cardiac tissue constructs to better recapitulate human heart function and drug responses. As these new platforms become increasingly sophisticated and high throughput, the drug screens result in larger multidimensional datasets...
October 12, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29032428/usability-operations-on-touch-mobile-devices-for-users-with-autism
#18
Angeles Quezada, Reyes Juárez-Ramírez, Samantha Jiménez, Alan Ramírez Noriega, Sergio Inzunza, Arnulfo Alanis Garza
The Autistic Spectrum Disorder is a cognitive disorder that affects the cognitive and motor skills; due that, users cannot perform digital and fine motor tasks. It is necessary to create software applications that adapt to the abilities of these users. In recent years has been an increase in the research of the use of technology to support autistic users to develop their communication skills and to improve learning. However, the applications' usability for disable users is not assessed objectively as the existing models do not consider interaction operators for disable users...
October 14, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29032347/vocalic-transitions-as-markers-of-speech-acoustic-changes-with-stn-dbs-in-parkinson-s-disease
#19
Vincent Martel-Sauvageau, Kris Tjaden
PURPOSE: Deep Brain Stimulation of the subthalamic nucleus (STN-DBS) effectively treats cardinal symptoms of idiopathic Parkinson's disease (PD) that cannot be satisfactorily managed with medication. Research is equivocal regarding speech changes associated with STN-DBS. This study investigated the impact of STN-DBS on vocalic transitions and the relationship to intelligibility. METHODS: Eight Quebec-French speakers with PD and eight healthy controls participated...
October 7, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/29030547/the-hidden-flow-structure-and-metric-space-of-network-embedding-algorithms-based-on-random-walks
#20
Weiwei Gu, Li Gong, Xiaodan Lou, Jiang Zhang
Network embedding which encodes all vertices in a network as a set of numerical vectors in accordance with it's local and global structures, has drawn widespread attention. Network embedding not only learns significant features of a network, such as the clustering and linking prediction but also learns the latent vector representation of the nodes which provides theoretical support for a variety of applications, such as visualization, link prediction, node classification, and recommendation. As the latest progress of the research, several algorithms based on random walks have been devised...
October 13, 2017: Scientific Reports
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