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https://www.readbyqxmd.com/read/28526687/ffa2-activation-combined-with-ulcerogenic-cox-inhibition-induces-duodenal-mucosal-injury-via-the-5-ht-pathway-in-rats
#1
Yasutada Akiba, Koji Maruta, Kazuyuki Narimatsu, Hyder Said, Izumi Kaji, Ayaka Kuri, Ken-Ichi Iwamoto, Atsukazu Kuwahara, Jonathan D Kaunitz
Serotonin (5-HT), predominantly synthesized and released by enterochromaffin cells, is implicated in gastrointestinal symptoms such as emesis, abdominal pain and diarrhea. Since luminal short-chain fatty acids (SCFAs) release 5-HT from enterochromaffin cells, which express the SCFA receptor FFA2 in rat duodenum, we examined the effects of the selective FFA2 agonist phenylacetamide-1 (PA1) on duodenal 5-HT release with consequent bicarbonate secretion (DBS) and on indomethacin (IND)-induced enteropathy. Intestinal injury was induced by IND (10 mg/kg, sc) with or without PA1...
May 19, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28526277/gene-expression-patterns-in-distinct-endoscopic-findings-for-eosinophilic-gastritis-in-children
#2
Masamichi Sato, Tetsuo Shoda, Hirotaka Shimizu, Kanami Orihara, Kyoko Futamura, Akio Matsuda, Yoshiyuki Yamada, Rie Irie, Takako Yoshioka, Toshiaki Shimizu, Yukihiro Ohya, Ichiro Nomura, Kenji Matsumoto, Katsuhiro Arai
BACKGROUND: Eosinophilic gastritis (EG) is clinicopathologically characterized by both marked gastric eosinophilia and clinical symptoms. The endoscopic findings in EG vary among patients, leading to clinical confusion. However, little is known about the relationship between precise endoscopic findings and the pathophysiological process responsible for EG. OBJECTIVE: We aimed to elucidate whether the gross endoscopic findings of EG can be classified into distinct gene expression profiles...
May 16, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28526245/lymphogenous-metastasis-to-the-transverse-colon-that-originated-from-signet-ring-cell-gastric-cancer-a-case-report-and-review-of-the-literature
#3
Hirofumi Sonoda, Kazushige Kawai, Hironori Yamaguchi, Koji Murono, Manabu Kaneko, Takeshi Nishikawa, Kensuke Otani, Kazuhito Sasaki, Koji Yasuda, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Hiroaki Nozawa, Soichiro Ishihara, Susumu Aikou, Hiroharu Yamashita, Tetsuo Ushiku, Yasuyuki Seto, Masashi Fukayama, Toshiaki Watanabe
Metastases to the colon are rare and a high-frequency primary region is the stomach. In cases of metastases to the colon, the morphological type of the metastatic region is mostly the infiltrating type of poorly differentiated or undifferentiated adenocarcinoma with lymph and blood vessel invasion. A case of cancer metastasis to the transverse colon that originated from advanced gastric cancer, which shows the difficulties in the precise diagnosis of metastases to the colon, is presented. In the present case, the gastric carcinoma was determined to be an advanced infiltrative ulcerative adenocarcinoma and the colon carcinoma was determined to be a superficial depressed adenocarcinoma...
May 16, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28525931/innovative-delivery-method-using-a-detachable-device-to-deliver-a-large-polyglycolic-acid-sheet-to-a-gastric-ulcer-perforation
#4
Hirohito Mori, Hideki Kobara, Asadur Rahman, Noriko Nishiyama, Akira Nishiyama, Yasuyuki Suzuki, Tsutomu Masaki
No abstract text is available yet for this article.
May 19, 2017: Endoscopy
https://www.readbyqxmd.com/read/28524250/one-plant-many-uses-a-review-of-the-pharmacological-applications-of-morinda-citrifolia
#5
REVIEW
Mylena Andréa Oliveira Torres, Isadora de Fátima Braga Magalhães, Renata Mondêgo-Oliveira, Joicy Cortez de Sá, Alessandra Lima Rocha, Ana Lucia Abreu-Silva
Morinda citrifolia, also known as noni, is commonly used in popular medicine in Brazil. Many parts of the noni tree are utilized in such practices, including the roots, leaves and seeds. Through a search of online databases, the present article reviews 92 research studies on the biological actions of M. citrifolia. The paper will discuss the therapeutic effects of noni and its compounds in a variety of forms of presentation, focusing on studies that support its traditional use. A large and diverse number of properties were identified, which were divided into immunostimulatory, antitumor, antidiabetic, anti-obesity, antibacterial and anti-septic, antifungal, antiviral, leishmanicidal, antiinflammatory, antinociceptive and analgesic, antioxidant, neuroprotective, wound healing, antiallergic, antiangiogenic, antiemetic and anti-nausea, anti-gastric ulcer and oesophagitis, anthelmintic, antimutagenic, antipsychotic, anxiolytic, photoprotective, anti-wrinkle and periodontal tissue regeneration activities...
May 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28523325/synchronous-gastric-tumors-case-presentation
#6
Carmen NeamŢu, Bogdan Dan Totolici, Octavian Marius CreŢu, Casiana Stănescu, Andrei Ardelean, Oana Badea, George Ciprian Pribac, Mircea Ovidiu Ciobanu, GarofiŢa Olivia Mateescu, Stelian ŞtefăniŢă Mogoantă
Synchronous gastric tumors, and, especially the presence of an adenocarcinoma and gastrointestinal stromal tumors, are less frequent. We present the case of a 75-year-old patient, with no gastrointestinal pathology in the medical history, who was admitted for marked asthenia, nausea, coffee grounds vomiting, inappetence, dizziness, weight loss and periodical epigastralgias. The clinical and imagistic examinations highlighted an ulcerative, infiltrative, bleeding tumor formation, present on the anterior side and subcardially on the small curvature...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28523030/detection-and-genotyping-of-helicobacter-pylori-among-gastric-ulcer-and-cancer-patients-from-saudi-arabia
#7
Fehmida Bibi, Sana Akhtar Alvi, Sara Ali Sawan, Muhammad Yasir, Ali Sawan, Asif A Jiman-Fatani, Esam I Azhar
BACKGROUND AND OBJECTIVES: Helicobacter pylori (H. pylori) infection is cause of several gastrointestinal diseases in humans. Virulence genes of H. pylori are associated with severity of disease and vary geographically. The aim of present study was to detect H. pylori in formalin-fixed paraffin-embedded (FFPE) tissues and further investigate prevalence of babA2, cagA, iceA1, iceA2, vacA s1/s2 and vacA m1/m2 genotypes in H. pylori from gastric cancer (GC) and gastric ulcer (GU) patients' biopsy samples...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28522905/strategies-used-by-helicobacter-pylori-to-establish-persistent-infection
#8
REVIEW
Amin Talebi Bezmin Abadi
Helicobacter pylori (H. pylori) is a Gram-negative and motile bacterium that colonizes the hostile microniche of the human stomach, then persists for the host's entire life, if not effectively treated. Clinically, H. pylori plays a causative role in the development of a wide spectrum of diseases including chronic active gastritis, peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Due to the global distribution of H. pylori, it is no exaggeration to conclude that smart strategies are contributing to adaptation of the bacterium to its permanent host...
April 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28522805/nitric-oxide-donor-protects-against-acetic-acid-induced-gastric-ulcer-in-rats-via-s-nitrosylation-of-trpv1-on-vagus-nerve
#9
Ting Han, Yan Tang, Jing Li, Bing Xue, Liping Gong, Jingxin Li, Xiao Yu, Chuanyong Liu
This study was conducted to investigate the effects of nitric oxide (NO) in acetic acid-induced gastric ulcer of rats and the underlying mechanisms. We found that peritoneal injection of sodium nitroprusside (SNP), a NO donor, decreased the ulcer area, inflammatory cell infiltration and MPO degree in acetic acid-induced gastric ulcer in rats. This effect was abolished by a transient receptor potential vanilloid 1 (TRPV1) antagonist or prior subdiaphragmatic vagotomy. SNP increased the jejunal mesenteric afferent discharge in a dose-depended manner, which was largely diminished by pretreatment of S-nitrosylation blocker N-ethylmaleimide, TRPV1 antagonist capsazepine, genetic deletion of TRPV1, or vagotomy...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28522175/pharmacological-inhibition-of-soluble-epoxide-hydrolase-or-genetic-deletion-reduces-diclofenac-induced-gastric-ulcers
#10
Sumanta Kumar Goswami, Amelia Ann Rand, Debin Wan, Jun Yang, Bora Inceoglu, Melany Thomas, Christophe Morisseau, Guang-Yu Yang, Bruce D Hammock
AIMS: This research was conducted to evaluate the hypothesis that gastric ulcers caused by the NSAID diclofenac sodium (DCF) can be prevented by the soluble epoxide hydrolase inhibitor TPPU. MAIN METHODS: Mice were administered a single dose of 10, 30 or 100mg/kg of DCF. Once an ulcerative dose of DCF was chosen, mice were pretreated with TPPU for 7days at 0.1mg/kg to evaluate anti-ulcer effects of the sEH inhibitor on anatomy, histopathology, pH, inflammatory markers and epithelial apoptosis of stomachs...
May 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28516757/gastric-perforation-caused-by-an-intragastric-balloon-endoscopic-findings
#11
In Kyung Yoo, Hoon Jai Chun, Yoon Tae Jeen
Intragastric balloon (IGB) insertion has been most frequently used in the West as an effective endoscopic treatment for morbid obesity, in practice. Recently, there is a growing number of cases requiring IGB deployment for obesity treatment in Korea. One of the reported complications of IGB use is gastric perforation. A 47-year-old woman was admitted to the hospital with mild symptoms, 7 weeks after having an IGB placed. Esophagogastroduodenoscopy was performed and gastric ulcer perforation was observed in the ulcer base, where food particles were impacted...
May 18, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28516058/comparison-of-amoxicillin-and-metronidazole-effect-on-three-drug-regimen-for-the-treatment-of-helicobacter-pylori-infection-in-children
#12
Karam-Ali Kasiri, Abolfazl Khoshdel, Afshin Karimi, Morteza Sedehi, Niloufar Kasiri
Helicobacter pylori is an important risk factor for chronic gastritis, peptic ulcer, and gastric cancer. Three-drug regimen is the first-line treatment for this infection, but the response rate to treatment varies in different geographical regions. This study was conducted to comparatively determine the effect of amoxicillin and metronidazole on three-drug regimen to treat H. pylori infection in 1-15-year-old children. This clinical trial was conducted on 82 patients aged 1-15 years with convenience sampling referring to the Endoscopy Unit of Hajar Hospital, Shahrekord...
April 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28514380/-transcatheter-embolization-in-prevention-of-recurrent-bleeding-from-stomach-ulcers
#13
N V Lebedev, G E Belozerov, A E Klimov, P Yu Sokolova, A A Spasskiy, A A Barkhudarov
AIM: To evaluate an efficacy of endovascular hemostasis in patients with gastric ulcerative bleeding and high risk of recurrent bleeding and death. MATERIAL AND METHODS: The work is based on a study of the results in 30 patients with gastric ulcerative bleeding, high risk of recurrent bleeding (rebleeding forecast system (RFS) score over 17) and high risk of death (SAPS II score over 30). We attempted transcatheter embolization of left gastric artery to prevent rebleeding...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28513226/application-of-proteomics-to-the-study-of-helicobacter-pylori-and-implications-for-the-clinic
#14
Giulia Bernardini, Natale Figura, Antonio Ponzetto, Barbara Marzocchi, Annalisa Santucci
Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the gastric epithelium and mucous layer of more than half the world's population. H. pylori is a primary human pathogen, responsible for the development of chronic gastritis, peptic ulceration and gastric cancer. Proteomics is impacting several aspects of medical research: understanding the molecular basis of infection and disease manifestation, identification of therapeutic targets and discovery of clinically relevant biomarkers. Areas covered: The main aim of the present review is to provide a comprehensive overview of the contribution of proteomics to the study of H...
May 17, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28512605/toxicity-status-and-antiulcerative-potential-of-sansevieria-trifasciata-leaf-extract-in-wistar-rats
#15
Osasenaga Macdonald Ighodaro, Abiola Muhammad Adeosun, Barinemene Francis Ojiko, Abeeb Taiwo Akorede, Oyindamola Fuyi-Williams
AIMS: The lethal dose 50% (LD50) and antiulcerative potentials of Sansevieria trifasciata (ST) leaf extract were investigated. MATERIALS AND METHODS: LD50 was determined through two routes of administration (intraperitoneal [i.p] and oral [p.o]) using the method of Lorke. The antiulcerative activity was evaluated in indomethacin-induced ulcer model (40 mg/kg body weight [BW], i.p, single dose) against a reference drug, cimetidine (100 mg/kg BW, p.o). ST was assessed at two different doses (200 and 400 mg/kg BW, p...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28512370/occupational-contact-allergy-to-omeprazole-and-ranitidine
#16
Inmaculada Herrera-Mozo, Pere Sanz-Gallen, Gabriel Martí-Amengual
Omeprazole is a proton pump inhibition and ranitidine is an H2 histamine receptor antagonist widely used in the treatment of gastroesophageal reflex disease, peptic ulcer disease, Zollinger-Ellison syndrome and as a protector of the gastric mucosae. We report a case of occupational contact allergy to omeprazole and ranitidine. A 48-year-old man, with no pre-existing history of atopy or lifestyle factors. He neither had any medical history of consumption of drugs such as ranitidine and omeprazole. He worked for 19 months in the pharmaceutical company that manufactured ranitidine base...
May 16, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28511679/evaluation-of-anti-inflammatory-and-gastric-anti-ulcer-activity-of-phyllanthus-niruri-l-euphorbiaceae-leaves-in-experimental-rats
#17
Ronia Mostofa, Shanta Ahmed, Mst Marium Begum, Md Sohanur Rahman, Taslima Begum, Siraj Uddin Ahmed, Riazul Haque Tuhin, Munny Das, Amir Hossain, Manju Sharma, Rayhana Begum
BACKGROUND: The medicinal plants signify a massive basin of potential phytoconstituents that could be valuable as a substitute to allopathic drugs or considered as an analogue in drug development. Phyllanthus niruri L. (Euphorbiaceae) is generally used in traditional medicine to treat ulcer and inflammation. In this project we investigated the methanolic extract of leaves of Phyllanthus niruri for anti-inflammatory and anti-ulcer activity. METHODS: The anti-inflammatory activity of methanol extract of Phyllanthus niruri leaves was evaluated at the doses of 100, 200 and 400 mg/kg, p...
May 16, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28507835/endoscopic-view-of-gastroduodenal-artery-coils-at-the-base-of-duodenal-ulcer-in-case-of-recurrent-massive-upper-gastrointestinal-bleed
#18
Rawaa Ebrahem, Salam Kadhem, John W Frey, William Salyers
Helicobacter pylori (H. pylori) infection is one of the major causes of bleeding peptic ulcer disease, which is associated with serious complications; therefore, the eradication of H. pylori is essential to prevent these devastating complications. Post-treatment follow-up is crucial to guarantee the eradication of the organism and may be conducted via the urea breath test, the stool antigen test, or a gastric biopsy. Acute massive upper gastrointestinal (UGI) bleeding is one of the most common complications of peptic ulcer disease...
April 13, 2017: Curēus
https://www.readbyqxmd.com/read/28506028/comparison-of-the-hospital-acquired-clostridium-difficile-infection-risk-of-using-proton-pump-inhibitors-versus-histamine-2-receptor-antagonists-for-prophylaxis-and-treatment-of-stress-ulcers-a-systematic-review-and-meta-analysis
#19
Mohamed Azab, Loomee Doo, Daniel H Doo, Yousif Elmofti, Muazer Ahmed, John Jay Cadavona, Xibei B Liu, Amaan Shafi, Moon Kyung Joo, Ji Won Yoo
Background/Aims: Although proton pump inhibitors (PPIs) have been widely used for the prevention and treatment of stress gastric ulcers in hospital settings, there are concerns that PPIs increase the risk of Clostridium difficile infection (CDI). However, little is known about the risk of CDI following PPI and histamine-2 receptor antagonist (H2RA) use. We evaluated the comparative hospital-acquired CDI occurrence risk associated with the concurrent use of PPIs versus H2RAs. Methods: A systematic search of PubMed, MEDLINE/ Ovid, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, and Google Scholar through August 19, 2016, identified 12 studies that reported the hospital-acquired CDI occurrence following H2RA and PPI use for the prevention and treatment of stress gastric ulcers...
May 17, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28503146/statin-therapy-is-associated-with-reduced-risk-of-peptic-ulcer-disease-in-the-taiwanese-population
#20
Chun-Jung Lin, Wei-Chih Liao, Yu-An Chen, Hwai-Jeng Lin, Chun-Lung Feng, Cheng-Li Lin, Ying-Ju Lin, Min-Chuan Kao, Mei-Zi Huang, Chih-Ho Lai, Chia-Hung Kao
Although statin use may affect the severity of chronic gastritis and gastric cancer, no data exists about the relationship between statin therapy and risk of peptic ulcer disease (PUD) in patients. We investigated the effect of statin use and the incidence of PUD from the Taiwan National Health Insurance Research Database (NHIRD). A total of 35,194 patients records for medical claims were enrolled. We performed a population-based case-control analysis to compare the incidence of PUD in patients who were prescribed statins and that in patients who were not...
2017: Frontiers in Pharmacology
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