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https://www.readbyqxmd.com/read/29331316/pharmacological-activities-of-the-organic-extracts-and-chemical-fatty-acids-composition-of-the-petroleum-ether-extract-from-haplophyllum-tuberculatum-leaves
#1
Assia Hamdi, Kaouther Majouli, Amal Abdelhamid, Hela Belghith, Imed Chraief, Abderrahman Bouraoui, Zohra Marzouk, Yvan Vander Heyden
ETHNOPHARMACOLOGICAL RELEVANCE: Haplophyllum tuberculatum is used in traditional medicine to treat many disorders including inflammation and pain. The aim of this study is to investigate the organic extracts from H. tuberculatum leaves against inflammation, gastric ulcer and pain. MATERIALS AND METHODS: Acute toxicity was studied in vivo to determine the toxic doses of the leaves organic extracts. Anti-inflammatory activity was also evaluated in vivo using carrageenan-induced paw edema in Wistar rats...
January 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29324238/immunization-with-recombinant-flid-confers-protection-against-helicobacter-pylori-infection-in-mice
#2
Amir Ghasemi, Nazanin Mohammad, Josef Mautner, Mehrnaz Taghipour Karsabet, Abolfazl Ardjmand, Rezvan Moniri
Nearly half of the world's population is infected with Helicobacter pylori. Clinical manifestations of this infection range from gastritis and peptic ulcers to gastric adenocarcinoma and lymphoma. Due to the emerging of antibiotic resistant strains and poor patient compliance of the antibiotic therapy, there is increasing interest in the development of a protective vaccine against H. pylori infection. The bacterial protein FliD forms a capping structure on the end of each flagellum which is critical to prevent depolymerization and structural degradation...
January 8, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29319835/gastrisk-bypass-fyller-50-%C3%A3-r-fetmaoperationen-som-visade-sig-fungera-mot-diabetes
#3
Per Videhult
Mason performed the first gastric bypass (GBP) for obesity in 1967 after having observed substantial weight loss in patients operated for gastric ulcer.  The weight loss after GBP is 30 % and 2/3 of patients with type II diabetes can stop their medication. Half of the patients can stop medication for hypertension or hyperlipidemia, 75% are cured from reflux and obstructive sleep apnea. GBP prolongs survival especially among diabetics. Restriction and malabsorption is of minor importance for weight loss. The mechanisms underlying weight loss and diabetes remissions are endocrine...
January 9, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29319361/cinnamon-cinnamomum-zeylanicum-as-an-antidote-or-a-protective-agent-against-natural-or-chemical-toxicities-a-review
#4
Mahyar Dorri, Shirin Hashemitabar, Hossein Hosseinzadeh
Cinnamon (Cinnamomum zeylanicum, Lauraceae) is a food additive greatly used for its taste. However, recently this medicinal plant has been brought to attention due to its medical effects. Cinnamon has constituents such as cinnamaldehyde and cinnamic acid that offers some health benefits including antioxidant and free-radical scavenging properties, lowering of blood glucose, anti-cholesterolemic, analgesic, antimicrobial, anti-inflammatory, anti-yeast, anti-secretagogue, and anti-gastric ulcer effects. This review summarizes various in vitro and animal studies on the protective effects of cinnamon against natural and chemical toxins...
January 10, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29319212/synergistic-glycosylation-as-key-to-the-chemical-synthesis-of-an-outer-core-octasaccharide-of-helicobacter-pylori
#5
Jian Yin, Xiaopeng Zou, Chunjun Qin, Claney L Pereira, Guangzong Tian, Jing Hu, Peter H Seeberger
Helicobacter pylori, a widespread gastric bacterial pathogen that infects 90% of the population in developing countries, causes chronic gastritis, peptic ulcers and gastric cancer. Battling H. pylori infection is a serious challenge due to the increased resistance to antibiotics and the lack of vaccines. The lipopolysaccharide covering the H. pylori cell-surface outer membrane is an attractive target for the development of a glycoconjugate vaccine. Here, we report a [3+5] convergent synthesis of an outer core octasaccharide of H...
January 10, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29319200/the-rise-and-fall-of-peptic-ulceration-a-disease-of-civilization
#6
REVIEW
Ian C Roberts-Thomson
Humans and Helicobacter pylori have evolved and adapted over tens of thousands of years. Yet peptic ulcer disease appeared to be rare prior to the 19th century. The prevalence of peptic ulcer disease increased between 1850 and 1900 and culminated in a cohort at high risk that was born at the end of the 19th century. This coincided with the provision of safe water and improvements in sanitation and personal hygiene. One hypothesis for the emergence of peptic ulcer disease focuses on the rate of development of atrophic gastritis induced by Helicobacter pylori...
January 10, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29313127/efficacy-of-innovative-polyglycolic-acid-sheet-device-delivery-station-system-a-randomized-prospective-study
#7
Hirohito Mori, Yu Guan, Hideki Kobara, Seiki Kobayashi, Noriko Nishiyama, Nobuya Kobayashi, Tsutomu Masaki
BACKGROUND: Although there have been several reports of treating large post-endoscopic submucosal dissection (ESD) ulcers by covering them with a polyglycolic acid sheet (PGAs), this approach presents problems regarding PGAs delivery. This study assessed the usefulness of a device delivery station system (DDSS) to evaluate the appropriate and rapid PGAs coating method with DDSS. METHODS: Thirty-nine of 41 patients who were diagnosed with early gastric cancer over 20 mm in diameter and pathologically diagnosed with well-differentiated adenocarcinoma were randomly allocated to the following two groups according to delivery method: the conventional PGAs delivery group (C group) (n = 19) and the new DDSS group (DDSS group) (n = 20)...
January 8, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29306012/preliminary-study-and-bioinformatics-analysis-on-the-potential-role-of-cagq-in-type-iv-secretion-system-of-h-pylori
#8
Yizheng Yao, Yixin Shen, Linqi Zhu, Ying Ni, Hua Wang, Shihe Shao
Helicobacter pylori (H.pylori), is a major causative agent of chronic gastritis, gastric carcinoma and duodenal ulcer. Remarkably, H.pylori carries cytotoxin-associated gene pathogenicity island (CagPAI) which encodes a type IV secretion system (T4SS). T4SS is capable of forming a syringe-like structure to deliver oncoprotein cytotoxin-associated Antigen (CagA) into gastric epithelial cells and resulting in a cascade of events in host cells, such as induction of pro-inflammatory cytokines, alteration of cellular gene expression and cytoskeletal rearrangements...
January 3, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29305822/large-cell-neuroendocrine-carcinoma-arising-from-a-gastritis-cystica-polyposa
#9
Ryusaku Kusunoki, Hirofumi Fujishiro, Yuji Onoda, Shinsuke Suemitsu, Aya Fujiwara, Kousuke Tsukano, Satoshi Kotani, Daisuke Kuroki, Sayaka Ogawa, Satoshi Yamanouchi, Masahito Aimi, Satoko Ito, Youichi Miyaoka, Tatsuya Miyake, Naruaki Kohge, Tomonori Imaoka, Michio Takamura, Hideyuki Ohnuma, Shunji Ishihara, Yoshikazu Kinoshita
Gastritis cystica polyposa is a polypoid lesion that arises from the gastric mucosa at the gastrojejunal anastomotic site and is characterized by cystic dilation of the gastric glands. A 78-year-old man who underwent distal gastrectomy for a gastric ulcer with Billroth II reconstruction approximately 40 years previously, exhibited a gastritis cystica polyposa at the anastomotic site. Ulceration was observed on an annual endoscopic examination. Endoscopic ultrasonography revealed a submucosal hypoechoic mass with multiple cystic lesions...
January 5, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29302869/lanthanum-induced-mucosal-alterations-in-the-stomach-lanthanum-gastropathy-a-comparative-study-using-an-animal-model
#10
Kei Yabuki, Joji Haratake, Yojiro Tsuda, Eisuke Shiba, Hiroshi Harada, Kenji Yorita, Kazuyoshi Uchihashi, Atsuji Matsuyama, Keiji Hirata, Masanori Hisaoka
Lanthanum (La) carbonate (LC) is one of the most potent phosphate binders that prevents the elevation of serum phosphate levels in patients with end-stage renal diseases undergoing dialysis. LC binds strongly to dietary phosphate and forms insoluble complexes that pass through the gastrointestinal tract. La deposition in patients treated with LC is a recently documented finding particularly observed in gastric mucosa. We herein describe the detailed gastric mucosal lesions in 45 LC-treated patients and address the potential underlying pathologic mechanism using oral LC administration in rats...
January 4, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29302504/characteristics-of-upper-gastrointestinal-tract-involvement-in-korean-pediatric-crohn-s-disease-a-multicenter-study
#11
Ji Hyoung Park, Hye Na Nam, Ji-Hyuk Lee, Jeana Hong, Dae Yong Yi, Eell Ryoo, In Sang Jeon, Hann Tchah
Purpose: Crohn's disease (CD) can involve any site of the gastrointestinal tract (GIT). However, the characteristics of upper GIT involvement in CD are unclear, especially in the Eastern pediatric population. This study aimed to estimate the prevalence of upper GIT involvement and identify the clinical features of Korean children with CD. Methods: This was a retrospective multicenter cohort study that included 52 pediatric patients with CD who underwent esophagogastroduodenoscopy and biopsy...
December 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29302210/alleviation-of-ascorbic-acid-induced-gastric-high-acidity-by-calcium-ascorbate-in-vitro-and-in-vivo
#12
Joon-Kyung Lee, Sang-Hyuk Jung, Sang-Eun Lee, Joo-Hui Han, Eunji Jo, Hyun-Soo Park, Kyung-Sun Heo, Deasun Kim, Jeong-Sook Park, Chang-Seon Myung
Ascorbic acid is one of the most well-known nutritional supplement and antioxidant found in fruits and vegetables. Calcium ascorbate has been developed to mitigate the gastric irritation caused by the acidity of ascorbic acid. The aim of this study was to compare calcium ascorbate and ascorbic acid, focusing on their antioxidant activity and effects on gastric juice pH, total acid output, and pepsin secretion in an in vivo rat model, as well as pharmacokinetic parameters. Calcium ascorbate and ascorbic acid had similar antioxidant activity...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29302146/helicobacter-pylori-in-dyspepsia-phenotypic-and-genotypic-methods-of-diagnosis
#13
Vignesh Shetty, Mamatha Ballal, Girisha Balaraju, Shiran Shetty, Ganesh C Pai, Ramachandra Lingadakai
Background: Helicobacter pylori affects almost half of the world's population and therefore is one of the most frequent and persistent bacterial infections worldwide. H. pylori is associated with chronic gastritis, ulcer disease (gastric and duodenal), mucosa-associated lymphoid tissue lymphoma, and gastric cancer. Several diagnostic methods exist to detect infection and the option of one method or another depends on various genes, such as availability, advantages and disadvantages of each method, monetary value, and the age of patients...
October 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29294595/should-asymptomatic-young-men-with-iron-deficiency-anemia-necessarily-undergo-endoscopy
#14
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Background/Aims: There has been no evidence for the necessity of endoscopy in asymptomatic young men with iron deficiency anemia (IDA). To determine whether endoscopy should be recommended in asymptomatic young men with IDA, we compared the prevalence of gastrointestinal (GI) lesions between young men (< 50 years) with IDA and those without IDA. Methods: We conducted a case-control study on asymptomatic young men aged < 50 years who underwent both esophagogastroduodenoscopy (EGD) and colonoscopy as part of a health checkup between 2010 and 2014...
January 5, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29286296/anti-helicobacter-pylori-properties-of-the-ant-venom-peptide-bicarinalin
#15
Jesus Guzman, Nathan Téné, Axel Touchard, Denis Castillo, Haouaria Belkhelfa, Laila Haddioui-Hbabi, Michel Treilhou, Michel Sauvain
The venom peptide bicarinalin, previously isolated from the ant Tetramorium bicarinatum, is an antimicrobial agent with a broad spectrum of activity. In this study, we investigate the potential of bicarinalin as a novel agent against Helicobacter pylori, which causes several gastric diseases. First, the effects of synthetic bicarinalin have been tested against Helicobacter pylori: one ATCC strain, and forty-four isolated from stomach ulcer biopsies of Peruvian patients. Then the cytoxicity of bicarinalin on human gastric cells and murine peritoneal macrophages was measured using XTT and MTT assays, respectively...
December 29, 2017: Toxins
https://www.readbyqxmd.com/read/29286036/-perforated-chronic-gastric-ulcer-in-sliding-hiatus-hernia
#16
S G Gorin, V I Khrupkin, A E Kustov, B A Andronov, A A Stradymov, A A Pisarevskaya, A M Verenok, V D Lyutov
No abstract text is available yet for this article.
2017: Khirurgiia
https://www.readbyqxmd.com/read/29283449/oxaprozin-prodrug-as-safer-nonsteroidal-anti-inflammatory-drug-synthesis-and-pharmacological-evaluation
#17
Jaya P Peesa, Lakshmana R Atmakuri, Prasanna R Yalavarthi, Basaveswara R Mandava Venkata, Arun Rasheed, Vengalrao Pachava
Oxaprozin is a popular non-steroidal anti-inflammatory drug (NSAID) and its chronic oral use is clinically restricted due to its gastrointestinal (GI) complications. In order to circumvent the GI complications, oxaprozin was amended as a prodrug in a one-pot reaction using N,N-carbonyldiimidazole as an activating agent. Dextran of average molecular weight (60,000-90,000 Da) was exploited as a carrier in the process of oxaprozin prodrug production by esterification. The structural profiles of the synthesized oxaprozin prodrug were characterized by FT-IR and NMR spectroscopy...
December 28, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29282636/vonoprazan-a-novel-and-potent-alternative-in-the%C3%A2-treatment-of-acid-related-diseases
#18
REVIEW
Xiaoxiao Yang, Yueyue Li, Yiyuan Sun, Mingming Zhang, Chuanguo Guo, Iqtida Ahmed Mirza, Yan-Qing Li
Although proton pump inhibitors (PPIs) have been used widely, acid-related diseases are still associated with a huge burden on the health care system. Recently, the efficacy and safety of a new acid suppressant named vonoprazan in the treatment of acid-related diseases have been evaluated by a series of studies. As a novel potassium-competitive acid blocker, vonoprazan may provide reversible acid suppression by preventing K+ from binding to gastric H+/K+-ATPase. It has been clinically used for the short-term treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease and Helicobacter pylori (H...
December 27, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29282629/inflammatory-bowel-disease-is-not-a-contraindication-for-bariatric-surgery
#19
Stephanie Aelfers, Ignace M C Janssen, Edo O Aarts, Carolijn Smids, Marcel J Groenen, Frits J Berends
BACKGROUND: Inflammatory bowel diseases (IBD) are listed as a contraindication for bariatric surgery in various guidelines due to a theoretical higher complication risk. Therefore, little is known about safety and efficacy of bariatric surgery in IBD patients. AIM: We assessed the safety and efficacy of bariatric surgery and postoperative quality of life (QoL) in IBD patients. SETTING: The study was conducted in a large peripheral hospital in the Netherlands...
December 27, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29280013/preoperative-predictors-of-beyond-endoscopic-submucosal-dissection-indication-or-lymphovascular-invasion-in-endoscopic-resection-for-early-gastric-cancer
#20
Su Jin Kim, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Hyeong Seok Nam, Dae Gon Ryu
BACKGROUND: To successfully resect early gastric cancer (EGC), prediction of lymph node metastasis is essential. Beyond endoscopic submucosal dissection (ESD) indication or lymphovascular invasion (LVI) are known risk factors associated with lymph node metastasis. However, accurate prediction of tumor invasion depth or LVI is impossible before endoscopic resection even when endoscopic ultrasound is used. The aim of this study was to identify the predictive factors associated with beyond ESD indication or LVI after ESD for EGC...
December 26, 2017: Surgical Endoscopy
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