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https://www.readbyqxmd.com/read/28436598/the-expression-of-helicobacter-pylori-tfs-plasticity-zone-cluster-is-regulated-by-ph-and-adherence-and-its-composition-is-associated-with-differential-gastric-il-8-secretion
#1
Bruno Silva, Alexandra Nunes, Filipa F Vale, Raquel Rocha, João Paulo Gomes, Ricardo Dias, Mónica Oleastro
BACKGROUND: Helicobacter pylori virulence is associated with different clinical outcomes. The existence of an intact dupA gene from tfs4b cluster has been suggested as a predictor for duodenal ulcer development. However, the role of tfs plasticity zone clusters in the development of ulcers remains unclear. We studied several H. pylori strains to characterize the gene arrangement of tfs3 and tfs4 clusters and their impact in the inflammatory response by infected gastric cells. METHODS: The genome of 14 H...
April 24, 2017: Helicobacter
https://www.readbyqxmd.com/read/28436350/prevalence-and-risk-factors-for-gastric-ulceration-in-pigs-slaughtered-at-170-kg
#2
F Gottardo, A Scollo, B Contiero, M Bottacini, C Mazzoni, S A Edwards
Oesophago-gastric ulcers (OGU) are a production and welfare problem in pigs. Stomach condition was scored for 22 551 pigs in 228 batches over a 7-month period at an abattoir in Italy processing heavy pigs for ham production. Mild or severe ulceration was observed in 20.7% of pigs, of which 13% had scar tissue. Variation between batches was high (0% to 36% prevalence of severe ulcers) and showed a significant effect of farm of origin (P<0.001). Overnight lairage increased the prevalence of mild ulcers (P<0...
April 24, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28434988/genotyping-of-helicobacter-pylori-shows-high-diversity-of-strains-circulating-in-central-vietnam
#3
Trung Nam Phan, Antonella Santona, Van Huy Tran, Thi Nhu Hoa Tran, Le Van An, Pietro Cappuccinelli, Salvatore Rubino, Bianca Paglietti
In Vietnam, the high prevalence of Helicobacter pylori infection represents a serious health problem. Virulence genes of H. pylori have been associated to increased risk of severe gastrointestinal diseases and the genetic background differs in geographical areas. We investigated cagA and vacA genotypes of H. pylori from dyspeptic patients from central Vietnam and the correlation with clinical outcomes; we also performed sequencing analysis of partial cagA gene. Overall, 84% of strains were cagA-positive, 75% were East-Asian type with a prevalence of vacAs1i1m1 and vacAs1i1m2 genotypes (66...
April 18, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28434266/factors-associated-with-the-efficacy-of-miniprobe-endoscopic-ultrasonography-after-conventional-endoscopy-for-the-prediction-of-invasion-depth-of-early-gastric-cancer
#4
Su Jin Kim, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Hyeong Seok Nam, Dong Hoon Shin
BACKGROUND: This study aimed to compare the accuracy of conventional endoscopy (CE) and endoscopic ultrasonography (EUS) to predict tumor invasion depth and to determine factors associated with higher accuracy of additional miniprobe EUS after CE. METHODS: Between May 2009 and February 2015, 273 lesions in 266 patients were subjected to miniprobe EUS after CE and curative treatment for well-to-moderately differentiated early gastric cancer (EGC). We reviewed preoperative CE and EUS findings and compared them to the pathologic findings...
April 22, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28434216/can-endoscopic-ulcerations-in-early-gastric-cancer-be-clearly-defined-before-endoscopic-resection-a-survey-among-endoscopists
#5
Sung Min Park, Byung-Wook Kim, Joon Sung Kim, Young Wook Kim, Gi Jun Kim, Seung Ji Ryu
Background/Aims: Early gastric cancer (EGC) with ulcerations can be treated via endoscopic resection (ER) when it is differentiated pathologically, limited to the mucosa, and <3 cm in diameter. The presence of ulceration is a key factor in deciding treatment strategies and is usually diagnosed during endoscopic examination. The aim of this study was to evaluate whether ulcerations in EGC can be clearly defined among endoscopists and which factors are related to the differences. Methods: A survey questionnaire, composed of demographic features and endoscopic images of seven patients with EGC, was presented to the endoscopists via e-mail...
April 24, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28433795/helicobacter-pylori-cagl-amino-acid-polymorphism-d58e59-pave-the-way-toward-peptic-ulcer-disease-while-n58e59-is-associated-with-gastric-cancer-in-north-of-iran
#6
Mina Rezaee Cherati, Javad Shokri-Shirvani, Ahmad Karkhah, Ramzan Rajabnia, Hamid Reza Nouri
The cagL protein of Helicobacter pylori involving in pathogenesis of gastroduodenal disorders. Therefore, the current study was conducted to determine the cagL amino acid polymorphisms in patients with gastric diseases. One hundred gastric biopsies were collected from gastritis, peptic ulcer (PUD) and gastric cancer (GC) patients and were screened for cagL using polymerase chain reaction (PCR). Also, sequence variations of the cagL were assessed via sequence translation. The cagL geneopositivity was 71.6% in patients were infected with H...
April 19, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28432741/pharmacokinetic-and-pharmacodynamic-effects-of-two-omeprazole-formulations-on-stomach-ph-and-gastric-ulcer-scores
#7
S Raidal, F M Andrews, S G Nielsen, G Trope
REASONS FOR PERFORMING THE STUDY: Limited data are available on the relative pharmacokinetics and pharmacodynamics of different omeprazole formulations. OBJECTIVES: To compare pharmacokinetic and pharmacodynamic effects of a novel omeprazole formulation against a currently registered product. STUDY DESIGN: Masked two period, two treatment crossover. METHODS: Twelve clinically healthy horses were studied over two 6-day treatment periods...
April 22, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28432383/increased-blood-cadmium-levels-were-not-associated-with-increased-fracture-risk-but-with-increased-total-mortality-in-women-the-malm%C3%A3-diet-and-cancer-study
#8
L Moberg, P M Nilsson, G Samsioe, G Sallsten, L Barregard, G Engström, C Borgfeldt
This study aimed to investigate if high levels of blood cadmium at baseline were associated with increased fracture risk during follow-up in middle-aged women. No increased fracture risk was observed during follow-up, but women with higher levels of cadmium had an increased overall mortality. INTRODUCTION: Exposure to high levels of cadmium has been associated with an increased fracture risk. The aim was to investigate a perceived association between low levels of blood cadmium (B-Cd) at baseline and risk of first incident fracture...
April 21, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28429247/a-review-of-the-novel-application-and-potential-adverse-effects-of-proton-pump-inhibitors
#9
REVIEW
Li-Yuan Yu, Lu-Ning Sun, Xue-Hui Zhang, Yue-Qi Li, Lei Yu, Zi-Qing-Yun Yuan, Ling Meng, Hong-Wen Zhang, Yong-Qing Wang
Proton pump inhibitors (PPIs) are known as a class of pharmaceutical agents that target H(+)/K(+)-ATPase, which is located in gastric parietal cells. PPIs are widely used in the treatment of gastric acid-related diseases including peptic ulcer disease, erosive esophagitis and gastroesophageal reflux disease, and so on. These drugs present an excellent safety profile and have become one of the most commonly prescribed drugs in primary and specialty care. Except for gastric acid-related diseases, PPIs can also be used in the treatment of Helicobacter pylori infection, viral infections, respiratory system diseases, cancer and so on...
April 20, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28427217/mean-platelet-volume-platelet-distribution-width-and-carcinoembryonic-antigen-to-discriminate-gastric-cancer-from-gastric-ulcer
#10
Zhi-Yuan Yun, Na Li, Xin Zhang, Huan Zhang, Yue Bu, Yuxiang Sun, Tiemin Liu, Rui-Tao Wang, Kai-Jiang Yu
Activated platelets are involved in cancer development and progression. Mean platelet volume (MPV) and platelet distribution width (PDW) are early indexes of platelet activation. The objectives of this study were to investigate the ability of MPV, PDW and carcinoembryonic antigen (CEA) individually or in combination, to distinguish between gastric cancer and gastric ulcer. The study involved 194 patients with gastric cancer, 191 patients with gastric ulcer, and 185 control subjects. Subjects' characteristics and hematologic tests data at initial diagnosis were collected...
March 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421456/filling-the-void-a-review-of-intragastric-balloons-for-obesity
#11
REVIEW
Patrick Laing, Tuan Pham, Linda Jo Taylor, John Fang
Endoscopic bariatric therapies are predicted to become much more widely used in North America for obese patients who are not candidates for bariatric surgery. Of all the endoscopic bariatric therapies, intragastric balloons (IGBs) have the greatest amount of clinical experience and published data supporting their use. Three IGBs are FDA approved and are now commercially available in the USA (Orbera, ReShape Duo, and Obalon) with others likely soon to follow. They are generally indicated for patients whose BMI ranges from 30 to 40 mg/kg(2) and who have failed to lose weight with diet and exercise...
April 18, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28420890/endoscopic-manifestations-and-clinical-characteristics-of-cytomegalovirus-infection-in-the-upper-gastrointestinal-tract
#12
Masaya Iwamuro, Eisei Kondo, Takehiro Tanaka, Hideharu Hagiya, Seiji Kawano, Yoshiro Kawahara, Fumio Otsuka, Hiroyuki Okada
We retrospectively analyzed the cases of 14 patients (9 women, 5 men, mean age: 51.6 years) with cytomegalovirus (CMV) involvement in the esophagus, stomach, and/or duodenum diagnosed at a single center, to determine their endoscopic features and clinical backgrounds. Thirteen patients (92.9%) had hematologic disease; the other had rheumatoid arthritis. Of the former, 12 patients underwent allogeneic hematopoietic stem cell transplantation, and 9 of these patients had graft-versus-host disease (GVHD) before undergoing esophagogastroduodenoscopy (EGD)...
April 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28418004/host-determinants-of-expression-of-the-helicobacter-pylori-baba-adhesin
#13
Mary E Kable, Lori M Hansen, Cathy M Styer, Samuel L Deck, Olena Rakhimova, Anna Shevtsova, Kathryn A Eaton, Miriam E Martin, Pär Gideonsson, Thomas Borén, Jay V Solnick
Expression of the Helicobacter pylori blood group antigen binding adhesin A (BabA) is more common in strains isolated from patients with peptic ulcer disease or gastric cancer, rather than asymptomatic colonization. Here we used mouse models to examine host determinants that affect H. pylori BabA expression. BabA expression was lost by phase variation as frequently in WT mice as in RAG2-/- mice that do not have functional B or T cells, and in MyD88-/-, TLR2-/- and TLR4-/- mice that are defective in toll like receptor signaling...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28417435/lachnospiraceae-shift-in-the-microbial-community-of-mice-faecal-sample-effects-on-water-immersion-restraint-stress
#14
Shiyin Li, Zelin Wang, Yun Yang, Sha Yang, Chenchen Yao, Kaiyun Liu, Sixin Cui, Quanming Zou, Hongwu Sun, Gang Guo
Stress, including both psychological and physical stimulation, can cause changes in the microbiota and mucosal function of the gastrointestinal system. There are few research studies available about the faecal microbiota changes after stress, such as water immersion restraint stress (WIRS). Therefore, in this study, we focused on analysing the composition changes of faecal microbiota in WIRS mice. The WIRS model, in which Blab/c mice were immersed in 21 ± 2 °C water for 4 h each day for 14 days, was established...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28414996/a-case-of-multiple-synchronous-quadruple-cancers-of-the-stomach-sigmoid-colon-rectum-and-pancreas
#15
Atsushi Nanashima, Tetsuro Tominaga, Takashi Nonaka, Kouki Wakata, Masaki Kunizaki, Shuichi Tobinaga, Yorihisa Sumida, Shigekazu Hidaka, Naoe Kinoshita, Terumitsu Sawai, Takeshi Nagayasu
INTRODUCTION: Multiple primary neoplasms are relatively rare, but their incidence has increased because of aging and improvements in diagnostic imaging. PRESENTATION OF CASE: A 67-year-old man presented with epigastric pain. On upper gastrointestinal endoscopy, an ulcer was seen at the gastric angle, and biopsy showed moderately differentiated adenocarcinoma (AC). Colonoscopy demonstrated a 15-mm lesion in the sigmoid colon and a submucosal lesion in the lower rectum...
April 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28414670/diulafoy-s-lesion-an-uncanny-etiology-of-gastrointestinal-bleed
#16
V Gasia, O Lamendola
INTRODUCTION: Dieulafoy's lesion is a relatively rare, but potentially life-threatening, condition. It accounts for 1-2 percent of acute gastrointestinal (GI); bleeding. CASE: A 99-year-old woman was initially admitted due to left lower extremity cellulitis related to chronic venous stasis ulcer and was receiving broad-spectrum IV antibiotics. Upon admission to the medical floor, she had an episode of hematemesis and multiple bowel movements with black-tarry stools...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28413658/subcutaneous-metastasis-arising-from-gastric-cancer-a-case-report
#17
Tsutomu Namikawa, Eri Munekage, Masaya Munekage, Hiromichi Maeda, Tomoaki Yatabe, Hiroyuki Kitagawa, Michiya Kobayashi, Kazuhiro Hanazaki
A 59-year-old man was referred to the Kochi Medical School Hospital due to left shoulder pain. Physical examination revealed a nodular, painful mass lesion in the subcutaneous tissue of the right chest wall, with a diameter of ~2 cm. Esophagogastroduodenoscopy revealed a large ulcerated tumor in the lower gastric body near the lesser curvature, and biopsy specimens of the gastric and humeral lesions revealed poorly differentiated adenocarcinoma. Abdominal computed tomography revealed multiple low-density lesions in the liver and a well-defined, 2...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28413648/effects-of-hyperbaric-oxygen-treatment-on-gastric-cancer-cell-line-sgc7901
#18
Yinliang Qi, Jianfeng Ruan, Mei Wang, Yuanchang Dai, Qing Zhou, Shuyu Gui, Sumei Zhang, Yuan Wang
Hyperbaric oxygen (HBO) has been previously identified as an effective adjunct treatment option for the management of brain injury, diabetic ulcers and chronic wounds. However, the roles of HBO as an adjunctive therapy for tumors remain controversial. The present research project was performed to explore the effects of HBO treatment on proliferation, autophagy and endoplasmic reticulum stress response of the gastric cancer cell line, SGC7901. The present study demonstrated that, after subjecting SGC7901 cells to HBO treatment, the increase in cell proliferation was significant, compared with that of the control group...
April 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28413454/helicobacter-pylori-vaca-s1m1-genotype-but-not-caga-or-baba2-increase-the-risk-of-ulcer-and-gastric-cancer-in-patients-from-southern-mexico
#19
Adolfo Román-Román, Dinorah Nashely Martínez-Carrillo, Josefina Atrisco-Morales, Julio César Azúcar-Heziquio, Abner Saúl Cuevas-Caballero, Carlos Alberto Castañón-Sánchez, Roxana Reyes-Ríos, Reyes Betancourt-Linares, Salomón Reyes-Navarrete, Iván Cruz-Del Carmen, Margarita Camorlinga-Ponce, Enoc Mariano Cortés-Malagón, Gloria Fernández-Tilapa
BACKGROUND: The vacA, cagA and babA2 genotypes of Helicobacter pylori are associated with gastric pathology. The objectives were to determine the frequency of infection and distribution of the vacA, cagA and babA2 genotypes of H. pylori in patients with gastric ulcer, chronic gastritis and gastric cancer, and to evaluate the association of virulent genotypes with diagnosis. METHODS: We studied 921 patients with symptoms of dyspepsia or with presumptive diagnosis of gastric cancer...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28412148/no-evidence-to-support-a-role-for-helicobacter-pylori-infection-and-plasminogen-binding-protein-in-autoimmune-pancreatitis-and-igg4-related-disease-in-a-uk-cohort
#20
Emma L Culver, Wouter L Smit, Caroline Evans, Ross Sadler, Tamsin Cargill, Mateusz Makuch, Lai-Mun Wang, Berne Ferry, Paul Klenerman, Eleanor Barnes
BACKGROUND AND OBJECTIVES: Helicobacter pylori (H.pylori) plasminogen binding protein (PBP) has been proposed as an antigen triggering autoimmune pancreatitis (AIP), the pancreatic manifestation of IgG4-related disease (IgG4-RD). We investigated exposure to H. pylori infection, cytokine response and immunological memory to H. pylori PBP in a prospective IgG4-RD cohort in the UK. METHODS: Clinical and endoscopic evidence of peptic ulceration, serological H. pylori exposure and serum IgG4 levels were obtained in 55 IgG4-RD patients and 52 disease controls (DC) with autoimmune or inflammatory conditions with an elevated serum IgG4...
April 5, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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