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MiRNA 27a

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https://www.readbyqxmd.com/read/28638270/existence-of-a-strong-correlation-of-biomarkers-and-mirna-in-females-with-metabolic-syndrome-and-obesity-in-a-population-of-west-virginia
#1
Perrine Goguet-Rubio, Rebecca L Klug, Dana L Sharma, Krithika Srikanthan, Nitin Puri, Vishal H Lakhani, Alexandra Nichols, Kathleen M O'Hanlon, Nader G Abraham, Joseph I Shapiro, Komal Sodhi
Objectives: Metabolic syndrome causes complications like cardiovascular disease and type 2 diabetes mellitus (T2DM). As metabolic syndrome develops, altered levels of cytokines and microRNAs (miRNA) are measurable in the circulation. We aimed to construct a panel detecting abnormal levels of cytokines and miRNAs in patients at risk for metabolic syndrome. Methods: Participants included 54 patients from a Family Medicine Clinic at Marshall University School of Medicine, in groups of: Control, Obese, and Metabolic Syndrome (MetS)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28620131/exosomes-containing-differential-expression-of-microrna-and-mrna-in-osteosarcoma-that-can-predict-response-to-chemotherapy
#2
Ji-Feng Xu, Ya-Ping Wang, Shui-Jun Zhang, Yu Chen, Hai-Feng Gu, Xiao-Fan Dou, Bing Xia, Qing Bi, Shun-Wu Fan
A major challenge in osteosarcoma (OS) is the selection of the most effective chemotherapeutic agents for individual patients, while the administration of ineffective chemotherapy increases mortality and decreases quality of life in patients. This emphasizes the need to evaluate every patient's probability of responding to each chemotherapeutic agent. We developed a profiling strategy for serum exosomal microRNAs and mRNAs in OS patients with differential chemotherapeutic responses. Twelve miRNAs were up regulated and 18 miRNAs were under regulated significantly in OS patient with poor chemotherapeutic response when compared with those in good chemotherapeutic response (p<0...
June 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28560399/microrna-expression-analysis-during-fk506-induced-osteogenic-differentiation-in-rat-bone-marrow-stromal-cells
#3
Jing Zhang, Xiaoping Yu, Youcheng Yu, Yiming Gong
FK506 (also known as tacrolimus) is a potent immunosuppressive agent that is widely used in the treatment of graft-rejection and autoimmune diseases. FK506 has attracted additional attention owing to its potential role in osteogenic differentiation and bone formation. MicroRNAs (miRNAs) have been demonstrated to serve important roles in the regulation of osteogenic differentiation; however, identification of specific miRNAs and their roles in regulating FK506‑induced osteogenic differentiation have been poorly examined...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28523761/unraveling-the-expression-of-microrna-27a-nkg2d-in-peripheral-blood-mononuclear-cells-and-natural-killer-cells-of-pediatric-systemic-lupus-erythematosus-patients
#4
Shady K Sourour, Heba R Aboelenein, Noha M Elemam, Amira K Abdelhamid, Samia Salah, Ahmed I Abdelaziz
BACKGROUND AND AIM: The activity of natural killer (NK) cells is known to be decreased in systemic lupus erythematosus (SLE) patients. Nevertheless, the exact contribution of NK cells in the pathogenesis of SLE is still inconclusive. MicroRNAs (miRNAs), are small noncoding RNA molecules that play a fundamental role in regulating NK cell function. The objective of this study was to investigate the expression of miRNAs that might potentially target an essential activating receptor, NKG2D in peripheral blood mononuclear cells (PBMCs) and NK cells of SLE patients...
May 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28521462/microrna-gene-polymorphisms-and-the-risk-of-colorectal-cancer
#5
Guo-Qiang Rong, Xin-Mei Zhang, Bo Chen, Xiao-Dong Yang, Hao-Rong Wu, Wei Gong
The present study was carried out to demonstrate the epidemiological value of microRNA (miRNA) in colorectal cancer (CRC) by investigating the association between miRNA gene polymorphisms and the susceptibility to CRC. Multiple meta-analyses of reported data were conducted, and odds ratio values and 95% confidence intervals were used to assess these associations. Stata 11.0 software was used to analyze the data and the modified Jadad quality score was employed to evaluate the quality of the retrieved studies...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28502511/functional-analysis-of-new-3-untranslated-regions-genetic-variants-in-genes-associated-with-genetic-hypercholesterolemias
#6
Flor María Pérez-Campo, Isabel De Castro-Orós, Alicia Noriega, Montserrat Cofán, Itziar Lamiquiz-Moneo, Ana Cenarro, Emilio Ros, Fernando Civeira, Miguel Pocoví, José Carlos Rodríguez-Rey
BACKGROUND: Familial hypercholesterolemia (FH) is the best-described autosomal dominant genetic hypercholesterolemia (GH). Mutations in candidate genes can explain a high proportion of FH cases, but for many, no causative mutations are detected (designed non-FG-GH), suggesting the existence of additional genetic variants associated with the disease. OBJECTIVE: We aimed to identify new single-nucleotide variants (SNVs) located at the 3' untranslated regions (3'UTRs) of the low-density lipoprotein receptor, low-density lipoprotein receptor-related protein-associated protein 1, ATP-binding cassette sub-family G member 5, and sterol regulatory element-binding protein 2 genes in non-FH-GH individuals and investigated whether the association of these SNVs with non-FH-GH could be explained by changes in the affinity of regulatory microRNAs (miRNA) targeting the sequences modified by the SNVs...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28499456/role-of-micrornas-in-premature-ovarian-insufficiency
#7
REVIEW
Ying Guo, Junyan Sun, Dongmei Lai
Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unknown in approximately 90% of cases. POI could lead to infertility, osteoporosis, cardiovascular disorder, and cognitive dysfunction...
May 12, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28498428/differential-expression-profiles-of-micrornas-as-potential-biomarkers-for-the-early-diagnosis-of-lung-cancer
#8
Yanqiu Zhang, Jing Sui, Xian Shen, Chengyun Li, Wenzhuo Yao, Weiwei Hong, Hui Peng, Yuepu Pu, Lihong Yin, Geyu Liang
Lung cancer is one of the most lethal malignancies worldwide. To reduce the high morbidity and mortality of the disease, sensitive and specific biomarkers for early detection are urgently needed. Tumor-specific microRNAs (miRNAs) seem to be potential biomarkers for the early diagnosis and treatment of cancer. In this study, the microarray of miRNAs and mRNAs on the same samples was performed and the intersection taken with The Cancer Genome Atlas (TCGA) lung cancer miRNA/RNAseq dataset. Then, miRNA-mRNA regulatory network was constructed to identify miRNA candidates associated with lung cancer through integrating gene expression and miRNA-target prediction...
April 28, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28489914/mir-27a-and-mir-449b-polymorphisms-associated-with-a-risk-of-idiopathic-recurrent-pregnancy-loss
#9
HyungChul Rah, Ki Wha Chung, Ki Han Ko, Eun Sun Kim, Jung Oh Kim, Jung Hyun Sakong, Ji Hyang Kim, Woo Sik Lee, Nam Keun Kim
OBJECTIVE: MicroRNAs (miRNAs) regulate gene expression during the peri-implantation period. The purpose of this study was to investigate whether genetic polymorphisms in the four miRNAs associated with fetal or placental development play roles in the development of idiopathic recurrent pregnancy loss (RPL) in Korean females. STUDY DESIGN: A case-control study involving 225 controls and 387 women with at least two consecutively recurrent pregnancy losses between 1999 and 2012 was performed...
2017: PloS One
https://www.readbyqxmd.com/read/28485163/microarray-profiling-defines-circulating-micrornas-associated-with-myelodysplastic-syndromes
#10
M Dostalova Merkerova, A Hrustincova, Z Krejcik, H Votavova, E Ratajova, J Cermak, M Belickova
Circulating microRNAs (miRNAs) are non-coding RNAs secreted into body fluids, and aberrant levels of these miRNAs correlate with diseases of various origins, making them highly potential clinical biomarkers. We investigated the spectrum of circulating miRNAs in the plasma of myelodysplastic syndrome (MDS) patients to identify miRNAs showing discriminatory levels in the patients with different prognosis. Plasma samples were analyzed with microarrays to define miRNA profiles, and the deregulated miRNAs were further studied using droplet digital PCR...
May 9, 2017: Neoplasma
https://www.readbyqxmd.com/read/28484848/microrna-27a-b-mediates-endothelin-1-induced-ppar%C3%AE-reduction-and-proliferation-of-pulmonary-artery-smooth-muscle-cells
#11
Xinming Xie, Shaojun Li, Yanting Zhu, Lu Liu, Yilin Pan, Jian Wang, Wenhua Shi, Yang Song, Lan Yang, Li Gao, Weijin Zang, Manxiang Li
The down-regulation of peroxisome proliferator-activated receptor γ (PPARγ) expression has been found to correlate with the proliferation of pulmonary artery smooth muscle cells (PASMC), pulmonary vascular remodeling and pulmonary hypertension, while the molecular mechanisms underlying PPARγ reduction in PASMC remain largely unclear. The aim of the current study is to address this issue. Endothelin-1 (ET-1) dose- and time-dependently resulted in PPARγ reduction and proliferation of primary cultured rat PASMC, which was accompanied by the activation of nuclear factor-kappaB (NF-κB) and subsequent induction of microRNA-27a/b (miR-27a/b) expression...
May 8, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28475616/rodent-heart-failure-models-do-not-reflect-the-human-circulating-microrna-signature-in-heart-failure
#12
Eline L Vegter, Ekaterina S Ovchinnikova, Herman H W Silljé, Laura M G Meems, Atze van der Pol, A Rogier van der Velde, Eugene Berezikov, Adriaan A Voors, Rudolf A de Boer, Peter van der Meer
INTRODUCTION: We recently identified a set of plasma microRNAs (miRNAs) that are downregulated in patients with heart failure in comparison with control subjects. To better understand their meaning and function, we sought to validate these circulating miRNAs in 3 different well-established rat and mouse heart failure models, and correlated the miRNAs to parameters of cardiac function. METHODS: The previously identified let-7i-5p, miR-16-5p, miR-18a-5p, miR-26b-5p, miR-27a-3p, miR-30e-5p, miR-199a-3p, miR-223-3p, miR-423-3p, miR-423-5p and miR-652-3p were measured by means of quantitative real time polymerase chain reaction (qRT-PCR) in plasma samples of 8 homozygous TGR(mREN2)27 (Ren2) transgenic rats and 8 (control) Sprague-Dawley rats, 6 mice with angiotensin II-induced heart failure (AngII) and 6 control mice, and 8 mice with ischemic heart failure and 6 controls...
2017: PloS One
https://www.readbyqxmd.com/read/28440497/mir%C3%A2-27a-promotes-proliferation-migration-and-invasion-of-colorectal-cancer-by-targeting-fam172a-and-acts-as-a-diagnostic-and-prognostic-biomarker
#13
Wenjun Liu, Kai Qian, Xing Wei, Haijun Deng, Bei Zhao, Qing Chen, Jinqian Zhang, Hao Liu
Accumulating evidence shows that mircroRNAs (miRNAs) play a crucial role in the development of colorectal cancer. In our previous study, FAM172A was demonstrated to be a novel tumor suppressor gene in CRC. Therefore, the aim of the present study was to identify whether the miR‑27a could be a diagnostic and prognostic marker and the regulatory relationships between miR‑27a and FAM172A. We demonstrated high levels of miR‑27a expression in tissues of patients with CRC as well as in CRC cell lines. There was a positive correlation between the levels of miR‑27a and the poor overall survival of patients with CRC...
April 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28432871/mir-24-3p-is-overexpressed-in-hodgkin-lymphoma-and-protects-hodgkin-and-reed-sternberg-cells-from-apoptosis
#14
Ye Yuan, Joost Kluiver, Jasper Koerts, Debora de Jong, Bea Rutgers, F Reeny Abdul Razak, Martijn Terpstra, Boudewijn E Plaat, Ilja M Nolte, Arjan Diepstra, Lydia Visser, Klaas Kok, Anke van den Berg
miRNAs play important roles in biological processes, such as proliferation, metabolism, differentiation, and apoptosis, whereas altered expression levels contribute to diseases, such as cancers. We identified miRNAs with aberrant expression in Hodgkin lymphoma (HL) and investigated their role in pathogenesis. Small RNA sequencing revealed 84 significantly differentially expressed miRNAs in HL cell lines as compared to germinal center B cells. Three up-regulated miRNAs-miR-23a-3p, miR-24-3p, and miR-27a-3p-were derived from one primary miRNA transcript...
June 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28429622/pharmacoepigenomic-responses-of-antipsychotic-drugs-on-pharmacogenes-are-likely-to-be-modulated-by-mirnas
#15
Babu Swathy, Koramannil R Saradalekshmi, Indu V Nair, Chandrasekharan Nair, Moinak Banerjee
AIM: It is imperative to differentiate the role of host epigenetics from pharmacoepigenetics in resolving therapeutic response. Therefore, the objective was to identify how antipsychotic drugs influence epigenetic response on pharmacogenes. MATERIALS & METHODS: The study design was based on in vitro evaluation of pharmacoepigenetic response of haloperidol, clozapine and olanzapine. Post antipsychotic treatment, the alterations in expression of ABCB1, CYP1A2 and CYP3A4 were monitored, and followed up by promoter methylation and their target miRNA expression studies...
April 21, 2017: Epigenomics
https://www.readbyqxmd.com/read/28424619/retinal-and-circulating-mirnas-in-age-related-macular-degeneration-an-in-vivo-animal-and-human-study
#16
Giovanni L Romano, Chiara B M Platania, Filippo Drago, Salvatore Salomone, Marco Ragusa, Cristina Barbagallo, Cinzia Di Pietro, Michele Purrello, Michele Reibaldi, Teresio Avitabile, Antonio Longo, Claudio Bucolo
Age related macular degeneration (AMD) is the leading cause of blindness among people aged 50 and over. Retinal deposition of amyloid-β (Aβ) aggregates in AMD patients has suggested a potential link between AMD and Alzheimer's disease (AD). We have evaluated the differential retinal expression profile of miRNAs in a rat model of AMD elicited by Aβ. A serum profile of miRNAs in AMD patients has been also assessed using single TaqMan assay. Analysis of retina from rats intravitreally injected with Aβ revealed that miR-27a, miR-146a, and miR-155 were up-regulated in comparison to control rats...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28401000/mirna-27a-promotes-the-proliferation-and-invasion-of-human-gastric-cancer-mgc803-cells-by-targeting-sfrp1-via-wnt-%C3%AE-catenin-signaling-pathway
#17
Fang Wu, Jun Li, Ni Guo, Xiao-Hui Wang, Yu-Qian Liao
This study aims to elucidate the effects of microRNA-27a (miR-27a) on the proliferation and invasion of gastric cancer (GC) cells by targeting SFRP1 via Wnt/β-catenin signaling pathway. GC and normal adjacent tissues were collected from 273 GC patients. Human gastric cancer cell line (MGC803) and normal human gastric mucosal cell line (GES-1) were cultured. The miR-27a mRNA expression was analyzed using Quantitative real-time polymerase chain reaction (qRT-PCR). Immunohistochemistry (IHC) test was used to detect miR-27a and SFRP1 protein expressions...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28393229/dysregulated-mir-27a-3p-promotes-nasopharyngeal-carcinoma-cell-proliferation-and-migration-by-targeting-mapk10
#18
Lihua Li, Zhaohui Luo
miRNA-27a-3p is an important regulator of carcinogenesis and other pathological processes. However, its role in laryngeal carcinoma is still unknown. In our previous research, we found that miR-27a-3p expression was upregulated in nasopharyngeal carcinoma (NPC) using a microarray chip. In the present study, we identified miR-27a-3p as an endogenous promoter of metastatic invasion. The expression levels of miR-27a-3p were correlated with human metastatic progression outcomes and Kaplan-Meier survival. In silico database analyses revealed that Mapk10 is a potential target of miR-27a-3p, and luciferase reporter assay results revealed that miR-27a-3p directly inhibits the Mapk10 3' untranslated region (3'UTR)...
May 2017: Oncology Reports
https://www.readbyqxmd.com/read/28356525/microrna-mir-27-inhibits-adenovirus-infection-by-suppressing-the-expression-of-snap25-and-txn2
#19
M Machitani, F Sakurai, K Wakabayashi, K Nakatani, M Tachibana, H Mizuguchi
Recent studies have reported that host microRNAs (miRNAs) regulate infection with several types of viruses via various mechanisms, and that inhibition of the miRNA processing factors enhances or prevents viral infection. However, it has not been clarified whether these effects of miRNAs extend to adenovirus (Ad) infection. Here we show that miR-27a/b efficiently inhibit infection with an Ad via the down-regulation of SNAP25 and TXN2, which are members of the SNARE proteins and the thioredoxin family, respectively...
March 29, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28341869/the-profile-of-serum-micrornas-predicts-prognosis-for-resected-gastric-cancer-patients-receiving-platinum-based-chemotherapy
#20
Jianning Song, Jie Yin, Zhigang Bai, Jun Zhang, Hua Meng, Jun Cai, Wei Deng, Xuemei Ma, Zhongtao Zhang
BACKGROUND AND AIM: Adjuvant chemotherapy is an important component in the treatment of gastric cancer (GC) patients; however, some patients do not respond to the drugs. We aimed to develop a practical profile based on serum microRNAs (miRNAs) that can be used to predict patients likely to respond to treatment. METHODS: Microarrays were used to screen cisplatin-resistant SGC7901/DDP GC cells and the parental SGC7901 cell lines for miRNAs related to chemotherapy sensitivity...
May 2017: Digestive Diseases and Sciences
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