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MiRNA 27a

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https://www.readbyqxmd.com/read/29337929/integrated-analyses-reveal-overexpressed-notch1-promoting-porcine-satellite-cells-proliferation-through-regulating-the-cell-cycle
#1
Yiren Jiao, Bo Huang, Yu Chen, Guangliang Hong, Jian Xu, Chingyuan Hu, Chong Wang
Notch signaling as a conserved cell fate regulator is involved in the regulation of cell quiescence, proliferation, differentiation and postnatal tissue regeneration. However, how Notch signaling regulates porcine satellite cells (PSCs) has not been elucidated. We stably transfected Notch1 intracellular domain (N1ICD) into PSCs to analyze the gene expression profile and miRNA-seq. The analysis of the gene expression profile identified 295 differentially-expressed genes (DEGs) in proliferating-N1ICD PSCs (P-N1ICD) and nine DEGs on differentiating-N1ICD PSCs (D-N1ICD), compared with that in control groups (P-Control and D-Control, respectively)...
January 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29304813/the-association-between-pre-mir-27a-rs895819-polymorphism-and-myocardial-infarction-risk-in-a-chinese-han-population
#2
Meng-Yun Cai, Jie Cheng, Meng-Yuan Zhou, Li-Li Liang, Si-Min Lian, Xiao-Shan Xie, Shun Xu, Xinguang Liu, Xing-Dong Xiong
BACKGROUND: Accumulating evidences have shown that miRNAs are directly or indirectly involved in a variety of biological processes, and closely associated with diverse human diseases, including cardiovascular diseases. SNPs locating within pri/pre-miRNA can affect miRNA processing and binding ability of target genes. MiR-27a, miR-26a-1 miR-100, miR-126 and miR-218 were reported to be associated with pathogenesis of myocardial infarction (MI). Here we aimed to evaluate the potential association of five polymorphisms in these pri/pre-miRNAs with individual susceptibility to MI in a Chinese Han population...
January 6, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29302837/up-regulated-pro-inflammatory-micrornas-mirnas-in-alzheimer-s-disease-ad-and-age-related-macular-degeneration-amd
#3
Aileen I Pogue, Walter J Lukiw
Alzheimer's disease (AD) of the brain neocortex and age-related macular degeneration (AMD) of the retina are two complex neurodegenerative disorders, which (i) involve the progressive dysregulation and deterioration of multiple neurobiological signaling pathways, (ii) exhibit the temporal accumulation of pro-inflammatory lesions including the amyloid beta (Aβ) peptide-containing senile plaques of AD and the drusen of AMD, and (iii) culminate in an insidious inflammatory neurodegeneration ending, respectively, in neural cell atrophy and death and progressive loss of cognition and central visual function...
January 4, 2018: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29299796/analysis-of-circulating-extracellular-vesicle-associated-micrornas-in-cortisol-producing-adrenocortical-tumors
#4
Pál Perge, Ábel Decmann, Raffaele Pezzani, Irina Bancos, Ambrogio Fassina, Michaela Luconi, Letizia Canu, Miklós Tóth, Marco Boscaro, Attila Patócs, Peter Igaz
PURPOSE: Circulating microRNAs (miRNA) have been described in patients with adrenocortical tumors, but the expression of miRNAs in non-functioning and cortisol-producing tumors has not been yet compared. Therefore, the objective of this study was to evaluate the expression of plasma extracellular vesicle (EV)-associated microRNAs in patients with non-functioning adrenocortical adenoma (NFA), cortisol-producing adrenocortical adenoma (CPA) and cortisol-producing adrenocortical carcinoma (CP-ACC)...
January 3, 2018: Endocrine
https://www.readbyqxmd.com/read/29210414/enhanced-and-synergistic-downregulation-of-oncogenic-mirnas-by-self-assembled-branched-dna
#5
S Nahar, A K Nayak, A Ghosh, U Subudhi, S Maiti
miRNAs, a group of small non-coding RNA molecules, regulate the expression of many genes involved in various cellular processes. Acute evidence suggests that one miRNA can regulate many genes as its targets, while one gene can be targeted by many miRNAs that co-operatively regulate the gene. Thus, targeting a single miRNA is not sufficient enough to rescue the disease phenotype but it is also essential to target multiple miRNAs simultaneously. This inspired us to design a novel DNA nanostructure that can concurrently downregulate multiple oncomiRNAs...
December 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/29207155/mirna%C3%A2-27a-promotes-the-proliferation-and-inhibits-apoptosis-of-human-pancreatic-cancer-cells-by-wnt-%C3%AE-catenin-pathway
#6
Zhigang Cui, Geng Liu, Di Kong
A specific expression of miRNA in pancreatic cancer renders it the novel diagnostic marker of pancreatic cancer. Therefore, we investigated how the anticancer effect of miRNA‑27a suppressed cell growth and induced apoptosis of human pancreatic cancer cells. We upregulated miRNA‑27a expression in PANC-1 cells using miRNA‑27a mimic, which demonstrated that induction of cell growth and suppression of apoptosis of human pancreatic cancer cells were observed. However, anti‑miRNA‑27a inhibited cell growth and apoptosis in pancreatic cancer cells...
November 28, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29169171/mirnas-are-unlikely-to-be-involved-in-retinoid-receptor-gene-regulation-in-pancreatic-cancer-cells
#7
Shuai Yin, Tim Bleul, Yifan Zhu, Orkhan Isayev, Jens Werner, Alexandr V Bazhin
BACKGROUND/AIMS: Retinoid receptors and retinoic acid were reported to be down-regulated in pancreatic duct adenocarcinoma (PDAC) compared to normal pancreas. Yet the mechanism of the down-regulation of retinoid receptors is not well defined. The aim of this study was to find out whether selected dysregulated miRNAs in PDAC are responsible for the decreased level of retinoid receptors. METHODS: Bioinformatics, real-time PCR, western blot analysis as well as molecular manipulation with miRNA in cells of PDAC were carried out...
November 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29152124/identification-of-a-sixteen-microrna-signature-as-prognostic-biomarker-for-stage-ii-and-iii-colon-cancer
#8
Havjin Jacob, Luka Stanisavljevic, Kristian Eeg Storli, Kjersti E Hestetun, Olav Dahl, Mette P Myklebust
Despite advances in colon cancer research and novel therapies, high risk of recurrence remains a major challenge. This study reports miRNA expression profiling as a biomarker for the prognosis of TNM stage II and III colon cancer. Fresh frozen biopsies from the study cohort (N=111) were analyzed for miRNA by RT-qPCR and LASSO regression analysis was used to build a classifier of miRNAs. The prognostic accuracy was tested and the classifier was validated in an independent colon cohort (TCGA-COAD, N=209). The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29143999/microrna-27a-3p-inhibits-cell-viability-and-migration-through-down-regulating-dusp16-in-hepatocellular-carcinoma
#9
Jin-Mao Li, Jun Zhou, Zhen Xu, Hai-Jin Huang, Min-Jiang Chen, Jian-Song Ji
MicroRNA (miRNA or miR) has been shown to play an important role in the initiation and development in many different cancers. Here, we demonstrated down-regulated expression of miR-27a-3p in hepatocellular carcinoma (HCC) tissues in comparison with that in adjacent normal liver tissues based on the TCGA database. Cells viability and apoptosis was measured by CCK-8 and flow cytometry assay. Cell invasion and migration was measured by Transwell and wound healing assay. The effect of miR-27a-3p on DUSP16 expression was evaluated by luciferase assays, and western blot assay...
November 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29142030/plasma-microrna-profiles-in-patients-with-early-rheumatoid-arthritis-responding-to-adalimumab-plus-methotrexate-vs-methotrexate-alone-a-placebo-controlled-clinical-trial
#10
Jacob Sode, Sophine B Krintel, Anting Liu Carlsen, Merete L Hetland, Julia S Johansen, Kim Hørslev-Petersen, Kristian Stengaard-Pedersen, Torkell Ellingsen, Mark Burton, Peter Junker, Mikkel Østergaard, Niels H H Heegaard
OBJECTIVE: The aim was to identify plasma (i.e., cell-free) microRNA (miRNA) predicting antitumor necrosis and/or methotrexate (MTX) treatment response in patients enrolled in an investigator-initiated, prospective, double-blinded, placebo-controlled trial (The OPERA study, NCT00660647). METHODS: We included 180 disease-modifying antirheumatic drug-naive patients with early rheumatoid arthritis (RA) randomized to adalimumab (ADA; n = 89) or placebo (n = 91) in combination with MTX...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29128203/study-of-correlation-between-genetic-variants-in-three-microrna-genes-hsa-mir-146a-hsa-mir-502-binding-site-hsa-mir-27a-and-breast-cancer-risk
#11
S Parchami Barjui, S Reiisi, S O Ebrahimi, B Shekari
BACKGROUND AND AIM: MicroRNAs (miRNAs) represent noncoding RNAs that play a role in the gene regulation of oncogenes and tumor suppressors. Single nucleotide polymorphisms (SNPs) in miRNA genes are associated with risk of cancer. Some of these SNPs are more common including rs2910164 in the miR-146a, rs895819 in the miR-27a, and rs2910164 in the miR-502 binding site of the SET8. Our aim was to investigate the association between these polymorphisms and the risk of breast cancer in an Iranian population...
November 8, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29115608/microrna%C3%A2-27a-promotes-tumorigenesis-via-targeting-akt-in-triple-negative-breast-cancer
#12
Jing Wu, Zhihui Sun, Huijie Sun, Yanhua Li
Altered microRNA (miRNA/miR) expression regulates tumor development and progression in triple‑negative breast cancer (TNBC). The present study examined the effect of miR‑27a on proliferation, migration and invasion of TNBC cells in vitro and in vivo. An MTT assay was performed to examine the proliferation of MDA‑MB‑231 and MDA‑MB‑468 breast cancer cells with either overexpression of miR‑27a or downregulation of miR‑27a, in the presence or absence of radiation. The migratory and invasive abilities of MDA‑MB‑231 and MDA‑MB‑468 breast cancer cells were assessed by Transwell migration and Matrigel invasion assays...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29100439/genetic-polymorphisms-in-pre-mirnas-predict-the-survival-of-non-small-cell-lung-cancer-in-chinese-population-a-cohort-study-and-a-meta-analysis
#13
Lingzi Xia, Zhihua Yin, Xuelian Li, Yangwu Ren, Haibo Zhang, Yuxia Zhao, Baosen Zhou
Background: To explore the association of genetic polymorphisms in pre-miRNA 30c-1 rs928508 and pre-miRNA 27a rs895819 with non-small-cell lung cancer prognosis. Materials and Methods: 480 patients from five hospitals were enrolled in this prospective cohort study. They were followed up for five years. The association between genotypes and overall survival was assessed by Cox proportional hazards regression models. A meta-analysis was conducted to provide evidence for the effect of microRNA 27a rs895819 on cancer survival...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100393/down-regulation-of-traditional-oncomirs-in-plasma-of-breast-cancer-patients
#14
Dana Jurkovicova, Bozena Smolkova, Monika Magyerkova, Zuzana Sestakova, Viera Horvathova Kajabova, Ludovit Kulcsar, Iveta Zmetakova, Lenka Kalinkova, Tomas Krivulcik, Marian Karaba, Juraj Benca, Tatiana Sedlackova, Gabriel Minarik, Zuzana Cierna, Ludovit Danihel, Michal Mego, Miroslav Chovanec, Ivana Fridrichova
Deregulated expression of microRNAs has the oncogenic or tumor suppressor function in cancer. Since miRNAs in plasma are highly stable, their quantification could contribute to more precise cancer diagnosis, prognosis and therapy prediction. We have quantified expression of seven oncomiRs, namely miR-17/92 cluster (miR-17, miR-18a, miR-19a and miR-20a), miR-21, miR-27a and miR-155, in plasma of 137 breast cancer (BC) patients. We detected down-regulation of six miRNAs in patients with invasive BC compared to controls; however, only miR-20a and miR-27a down-regulations were statistically significant...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100284/exosomes-containing-differential-expression-of-microrna-and-mrna-in-osteosarcoma-that-can-predict-response-to-chemotherapy
#15
Ji-Feng Xu, Ya-Ping Wang, Shui-Jun Zhang, Yu Chen, Hai-Feng Gu, Xiao-Fan Dou, Bing Xia, Qing Bi, Shun-Wu Fan
A major challenge in osteosarcoma (OS) is the selection of the most effective chemotherapeutic agents for individual patients, while the administration of ineffective chemotherapy increases mortality and decreases quality of life in patients. This emphasizes the need to evaluate every patient's probability of responding to each chemotherapeutic agent. We developed a profiling strategy for serum exosomal microRNAs and mRNAs in OS patients with differential chemotherapeutic responses. Twelve miRNAs were up regulated and 18 miRNAs were under regulated significantly in OS patient with poor chemotherapeutic response when compared with those in good chemotherapeutic response (p<0...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098032/identification-of-mirna-and-genes-involving-in-osteosarcoma-by-comprehensive-analysis-of-microrna-and-copy-number-variation-data
#16
Tao Luo, Xiangli Yi, Wei Si
The aim of the present study was to understand the molecular mechanisms of osteosarcoma by comprehensive analysis of microRNA (miRNA/miR) and copy number variation (CNV) microarray data. Microarray data (GSE65071 and GSE33153) were downloaded from the Gene Expression Omnibus. In GSE65071, differentially expressed miRNAs between the osteosarcoma and control groups were calculated by the Limma package. Target genes of differentially expressed miRNAs were identified by the starBase database. For GSE33153, PennCNV software was used to perform the copy number variation (CNV) analysis...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29096313/regulation-of-pregnane-x-receptor-and-micrornas-on-detoxification-related-genes-expressions-in-mugilogobius-abei-under-the-exposure-to-diclofenac
#17
Peijia Ku, Chao Wang, Xiangping Nie, Ruikang Ou, Kaibing Li
Diclofenac (DCF) has been recognized as an emerging contaminant in aquatic environments. Though many studies have investigated the toxic effects of DCF in human and mammals, limited information is available for the responses of genes associated with detoxification metabolisms in non-target aquatic organisms such as fish. In the present study, a small benthic fish Mugilogobius abei, was chosen as the test organism and the effects of DCF on detoxification-related genes at transcriptional level in M. abei were investigated...
October 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29089199/microrna-27a-3p-affects-estradiol-and-androgen-imbalance-by-targeting-creb1-in-the-granulosa-cells-in-mouse-polycytic-ovary-syndrome-model
#18
Mingming Wang, Mei Liu, Jing Sun, Lina Jia, Shuoqian Ma, Jun Gao, Yunyun Xu, Hongwen Zhang, Suk Ying Tsang, Xiangdong Li
Polycystic ovary syndrome (PCOS) is a common endocrine abnormality in women characterized by a menstrual disturbance with chronic anovulation and hyperandrogenism, polycystic ovaries, and insulin resistance. MicroRNAs (miRNAs) are important fine-tune regulators involved in various physiological and pathological processes, but their actions are not fully understood. In this study, we observed the increased expression of miR-27a-3p in the ovaries of mice with PCOS and explored its functions in primary mouse granulosa cells (mGCs) and the mouse granulosa-like tumor cell line, KK-1, using several approaches...
December 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29065177/mir-27a-induced-by-colon-cancer-cells-in-hlecs-promotes-lymphangiogenesis-by-targeting-smad4
#19
Qi Xu, Jin-Lu Tong, Chen-Peng Zhang, Qian Xiao, Xiao-Lin Lin, Xiu-Ying Xiao
AIM: Metastasis of tumor cells occurs through lymphatic vessels, blood vessels and transcoelomic spreading. Growing evidence from in vivo and in vitro studies has indicated that tumor lymphangiogenesis facilitates metastasis. However, the regulation of lymphangiogenesis in colon cancer remains unclear. The aims of this study were to identify key miRNAs in colon cancer lymphangiogenesis and to investigate its target and mechanism. METHODS: miRNA microarray analysis was conducted to identify miRNAs in human lymphatic endothelial cells (HLECs) that were regulated by co-cultured human colon cancer cells...
2017: PloS One
https://www.readbyqxmd.com/read/28990745/diagnostic-value-of-circulating-microrna-27a-b-in-patients-with-acute-pulmonary-embolism
#20
Qian Wang, Junfen Ma, Zhiyun Jiang, Fan Wu, Jiedan Ping, Liang Ming
BACKGROUND: Circulating microRNAs (miRNAs) have been increasingly suggested as biomarkers for numerous diseases. The aims of this study were to evaluate the expression of plasma miR-27a/b in patients with acute pulmonary embolism (APE) and determine the possibility of miR-27a/b as diagnostic biomarkers for APE. METHODS: 78 APE patients diagnosed by computed tomographic pulmonary angiography (CTPA) and 70 age and gender matched normal volunteers were included in this study...
October 9, 2017: International Angiology: a Journal of the International Union of Angiology
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