keyword
https://read.qxmd.com/read/38475787/investigating-the-therapeutic-effects-and-mechanisms-of-carthamus-tinctorius-l-derived-nanovesicles-in-atherosclerosis-treatment
#21
JOURNAL ARTICLE
Rongfeng Yang, Fengxia Lin, Wenlin Wang, Gang Dai, Xiao Ke, Guifu Wu
BACKGROUND: Carthamus tinctorius L., a traditional herbal medicine used for atherosclerosis (AS), lacks a clear understanding of its therapeutic mechanisms. This study aimed to investigate the therapeutic effects and mechanisms of Carthamus tinctorius L.-derived nanovesicles (CDNVs) in AS treatment. METHODS: CDNVs were isolated and characterized using improved isolation methods. Transmission electron microscopy, nanoparticle tracking analysis, and protein analysis confirmed their morphology, size, and protein composition...
March 12, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38474059/tiny-guides-big-impact-focus-on-the-opportunities-and-challenges-of-mir-based-treatments-for-ards
#22
REVIEW
Chirag M Vaswani, Julia Simone, Jacqueline L Pavelick, Xiao Wu, Greaton W Tan, Amin M Ektesabi, Sahil Gupta, James N Tsoporis, Claudia C Dos Santos
Acute Respiratory Distress Syndrome (ARDS) is characterized by lung inflammation and increased membrane permeability, which represents the leading cause of mortality in ICUs. Mechanical ventilation strategies are at the forefront of supportive approaches for ARDS. Recently, an increasing understanding of RNA biology, function, and regulation, as well as the success of RNA vaccines, has spurred enthusiasm for the emergence of novel RNA-based therapeutics. The most common types of RNA seen in development are silencing (si)RNAs, antisense oligonucleotide therapy (ASO), and messenger (m)RNAs that collectively account for 80% of the RNA therapeutics pipeline...
February 28, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472669/variant-analysis-of-mirna-regulatory-genes-in-35-sporadic-lung-carcinoma-tumors
#23
JOURNAL ARTICLE
Özkan Bağcı, Ebru Marzioğlu Özdemir, Batuhan Şanlıtürk
UNLABELLED: Lung cancer is one of the cancer types with the highest mortality worldwide. The most frequently mutated genes known to be clinically important in lung cancers are EGFR, BRAF, and KRAS genes. Therefore, the therapeutic agents developed are directed against variants that cause over-activation of the EGFR-KRAS-BRAF-BRAF-MEK/ERK signalling pathway. However, different responses of patients to Tyrosine Kinase Inhibitors (TKIs) suggest that new prognostic biomarkers should be defined and epigenetic mechanisms may be related to this situation...
March 12, 2024: Doklady. Biochemistry and Biophysics
https://read.qxmd.com/read/38472205/neat1_1-confers-gefitinib-resistance-in-lung-adenocarcinoma-through-promoting-akr1c1-mediated-ferroptosis-defence
#24
JOURNAL ARTICLE
Shuman Zhen, Yunlong Jia, Yan Zhao, Jiali Wang, Boyang Zheng, Tianxu Liu, Yuqing Duan, Wei Lv, Jiaqi Wang, Fan Xu, Yueping Liu, Yi Zhang, Lihua Liu
Gefitinib is one of the most extensively utilized epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) for treating advanced lung adenocarcinoma (LUAD) patients harboring EGFR mutation. However, the emergence of drug resistance significantly compromised the clinical efficacy of EGFR-TKIs. Gaining further insights into the molecular mechanisms underlying gefitinib resistance holds promise for developing novel strategies to overcome the resistance and improve the prognosis in LUAD patients...
March 12, 2024: Cell Death Discovery
https://read.qxmd.com/read/38470557/sufentanil-suppresses-cell-carcinogenesis-via-targeting-mir-186-5p-hmgb1-axis-and-wnt-%C3%AE-catenin-pathway-in-non-small-cell-lung-cancer
#25
JOURNAL ARTICLE
Di Liu, Ye Huang, You Shang
Sufentanil is a common opioid anesthetic agent, which exerts anti-cancer properties in several cancer types. However, its action mechanisms in non-small cell lung cancer (NSCLC) are unclear. Therefore, the present study investigated the pharmacological effect of sufentanil on miRNAs in NSCLC treatment. In this study, after treatment with sufentanil, the proliferation, migration, invasion and apoptosis of A549 and H1299 NSCLC cell lines were measured by cell counting kit-8 (CCK-8) assay, colony formation assay, transwell assays and flow cytometry...
March 12, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38470324/thermophoretic-aggregation-imaging-of-tumor-derived-exosomes-by-crispr-cas13a-based-nanoprobes
#26
JOURNAL ARTICLE
Ping Zhou, Yingbo Pan, Bo Liu, Wei Pan, Na Li, Bo Tang
The inherent heterogeneity of tumor-derived exosomes holds great promise for enhancing the precision of cancer diagnostics. MicroRNAs (miRNAs) encapsulated in tumor-associated exosomes have emerged as valuable biomarkers for the early detection of cancers. Nevertheless, the flexible structure and inherent instability of RNA limit its application in biological diagnostics. The CRISPR-Cas13a system, distinguished by its target-responsive "collateral effect", represents a powerful tool for advancing cancer diagnostics...
March 12, 2024: Analytical Chemistry
https://read.qxmd.com/read/38469304/microrna-126-selected-with-broad-spectrum-analysis-of-micrornas-a-new-predictive-factor-for-the-effectiveness-of-immunotherapy-or-chemoimmunotherapy-in-advanced-nsclc-patients
#27
JOURNAL ARTICLE
Anna Grenda, Barbara Kuźnar-Kamińska, Ewa Kalinka, Paweł Krawczyk, Marek Sawicki, Agata Filip, Izabela Chmielewska, Małgorzata Frąk, Natalia Krzyżanowska, Janusz Milanowski
INTRODUCTION: Expression of PD-L1 on cancer cells is the only validated predictive factor for immunotherapy in NSCLC (Non-Small Cell Lung Cancer) patients. However, on this basis, it is difficult to predict the occurrence of resistance to immune checkpoint inhibitors (ICIs). MicroRNAs are widely studied as biomarkers of cancers. Our study was designed to determine whether microRNAs can be sensitive predictive factors in the qualification of NSCLC patients to first-line immunotherapy or chemoimmunotherapy...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38459511/circnox4-activates-an-inflammatory-fibroblast-niche-to-promote-tumor-growth-and-metastasis-in-nsclc-via-fap-il-6-axis
#28
JOURNAL ARTICLE
Yan Zhao, Yunlong Jia, Jiali Wang, Xiaolin Chen, Jingya Han, Shuman Zhen, Shuxian Yin, Wei Lv, Fan Yu, Jiaqi Wang, Fan Xu, Xinming Zhao, Lihua Liu
BACKGROUND: Cancer-associated fibroblasts (CAFs) orchestrate a supportive niche that fuels cancer metastatic development in non-small cell lung cancer (NSCLC). Due to the heterogeneity and plasticity of CAFs, manipulating the activated phenotype of fibroblasts is a promising strategy for cancer therapy. However, the underlying mechanisms of fibroblast activation and phenotype switching that drive metastasis remain elusive. METHODS: The clinical implications of fibroblast activation protein (FAP)-positive CAFs (FAP+ CAFs) were evaluated based on tumor specimens from NSCLC patients and bioinformatic analysis of online databases...
March 8, 2024: Molecular Cancer
https://read.qxmd.com/read/38458292/multiple-signal-amplification-strategy-induced-by-biomarkers-of-lung-cancer-a-self-powered-biosensing-platform-adapted-for-smartphones
#29
JOURNAL ARTICLE
Yujie Song, Yu Ya, Xiaotian Cen, Danyao Tang, Jinyue Shi, YeYu Wu, Hu Luo, Ke-Jing Huang, Xuecai Tan, Feiyan Yan
Lung cancer is a major malignant cancer with low survival rates, and early diagnosis is crucial for effective treatment. Herein, a biosensing platform that is self-powered derived from a capacitor-coupled EBFC has been developed for ultra-sensitive real-time identification of microRNA-21 (miRNA-21) with the assistance of a mobile phone. The flexible substrate of the platform is prepared on a carbon paper modified with graphdiyne and gold nanoparticles. The biosensor employs DNAzyme-mediated dual strand displacement amplification, which enhances the signal output intensity of the EBFC and improves selectivity...
March 6, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38455397/downregulated-antisense-lncrna-entpd3-as1-contributes-to-the-development-of-lung-adenocarcinoma
#30
JOURNAL ARTICLE
Hung-Hsing Chiang, Chai-Tung Ong, Chao-Yuan Chang, Kuan-Li Wu, Yu-Yuan Wu, Jia-Chen Lai, Tzu-Yen Shen, Jen-Yu Hung, Hsiao-Chen Lee, Ying-Ming Tsai, Ya-Ling Hsu
The poor outcome of patients with lung adenocarcinoma (LUAD) highlights the importance to identify novel effective prognostic markers and therapeutic targets. Long noncoding RNAs (lncRNAs) have generally been considered to serve important roles in tumorigenesis and the development of various types of cancer, including LUAD. Here, we aimed to investigate the role of ENTPD3-AS1 (ENTPD3 Antisense RNA 1) in LUAD and to explore its potential mechanisms by performing comprehensive bioinformatic analyses. The regulatory effect of ENTPD3-AS1 on the expression of NR3C1 was validated by siRNA-based silencing...
2024: American Journal of Cancer Research
https://read.qxmd.com/read/38452582/emerging-role-of-tumor-suppressing-micrornas-as-therapeutics-in-managing-non-small-cell-lung-cancer
#31
REVIEW
Shubham Singh, Sangeeta Saxena, Himani Sharma, Keshav Raj Paudel, Amlan Chakraborty, Ronan MacLoughlin, Brian G Oliver, Gaurav Gupta, Poonam Negi, Sachin Kumar Singh, Kamal Dua
Lung cancer (LC) is the second leading cause of death across the globe after breast cancer. There are two types of LC viz. small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC accounts for approximately 85% of all LC cases. NSCLC affects smokers and people who do not smoke and mainly arises in bronchi and peripheral lungs tissue. LC is often characterized by the alterations of key genes such as EGFR, Wnt/β-catenin signaling, ALK, MET, K-Ras and p53 and downstream signaling pathways associated with tumor growth, differentiation, and survival...
February 23, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38450681/expression-of-ahr-regulated-mirnas-in-non-small-cell-lung-cancer-in-smokers-and-never-smokers
#32
JOURNAL ARTICLE
T S Kalinina, V V Kononchuk, I S Valembakhov, V O Pustylnyak, V V Kozlov, L F Gulyaeva
Smoking is a risk factor for non-small cell lung cancer (NSCLC). The most common subtypes of NSCLC are lung adenocarcinoma (LAC) and squamous cell carcinoma (SCC). The cigarette smoke contains aryl hydrocarbon receptor (AhR) ligands, such as benzo(a)pyrene (BaP). By activating the AhR, BaP can change the expression of many genes, including miRNA-encoding genes. In this study, we have evaluated the expression of few miRNAs potentially regulated by AhR (miR-21, -342, -93, -181a, -146a), as well as CYP1A1, a known AhR target gene, in lung tumor samples from smoking (n=40) and non-smoking (n=30) patients with LAC and from smoking patients with SCC (n=40)...
February 2024: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://read.qxmd.com/read/38449802/human-adenovirus-type-3-restores-pharmacologically-inhibited-exosomal-cargo-in-lung-carcinoma-cells
#33
JOURNAL ARTICLE
Ayodeji O Ipinmoroti, Rachana Pandit, Brennetta J Crenshaw, Brian Sims, Qiana L Matthews
Introduction: Drug repurposing is fast growing and becoming an attractive approach for identifying novel targets, such as exosomes for cancer and antiviral therapy. Exosomes are a specialized class of extracellular vesicles that serve as functional mediators in intercellular communication and signaling that are important in normal physiological functions. A continuously growing body of evidence has established a correlation between the abnormal release of exosomes with various viral disease pathologies including cancer...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38446215/an-insight-into-thymidylate-synthase-inhibitor-as-anticancer-agents-an-explicative-review
#34
REVIEW
Aratrika Sen, Dipanjan Karati
Cancer, a widespread challenge to global health, remains a puzzle of intricate molecular dynamics. This review article delves into the mystery of cancer, with a keen focus on understanding the contributory role of thymidylate synthase (TS) in cancer. TS, a vital enzyme in DNA synthesis and repair, emerges as a significant player in the narrative of cancer development. The conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) is a major step in producing DNA. Numerous malignancies, including those of the breast, colon, lung, and ovary, have been linked to dysregulation of TS activity...
March 6, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38445045/biodistribution-and-safety-of-a-single-raav3b-aat-vector-for-silencing-and-replacement-of-alpha-1-antitrypsin-in-cynomolgus-macaques
#35
JOURNAL ARTICLE
Meghan Blackwood, Alisha M Gruntman, Qiushi Tang, Debora Pires-Ferreira, Darcy Reil, Oleksandr Kondratov, Damien Marsic, Sergei Zolotukhin, Gwladys Gernoux, Allison M Keeler, Christian Mueller, Terence R Flotte
Alpha-1 antitrypsin deficiency (AATD) is characterized by both chronic lung disease due to loss of wild-type AAT (M-AAT) antiprotease function and liver disease due to toxicity from delayed secretion, polymerization, and aggregation of misfolded mutant AAT (Z-AAT). The ideal gene therapy for AATD should therefore comprise both endogenous Z-AAT suppression and M-AAT overexpression. We designed a dual-function rAAV3B (df-rAAV3B) construct, which was effective at transducing hepatocytes, resulting in a considerable decrease of Z-AAT levels and safe M-AAT augmentation in mice...
March 14, 2024: Molecular Therapy. Methods & Clinical Development
https://read.qxmd.com/read/38443855/identification-of-biomarkers-and-pathways-for-the-sars-cov-2-infections-in-obstructive-sleep-apnea-patients-based-on-machine-learning-and-proteomic-analysis
#36
JOURNAL ARTICLE
Hong Luo, Jisong Yan, Rui Gong, Dingyu Zhang, Xia Zhou, Xianguang Wang
BACKGROUND: The prevalence of obstructive sleep apnea (OSA) was found to be higher in individuals following COVID-19 infection. However, the intricate mechanisms that underscore this concomitance remain partially elucidated. The aim of this study was to delve deeper into the molecular mechanisms that underpin this comorbidity. METHODS: We acquired gene expression profiles for COVID-19 (GSE157103) and OSA (GSE75097) from the Gene Expression Omnibus (GEO) database...
March 5, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38442573/therapeutic-potential-of-adsc-ev-derived-lncrna-dleu2-a-novel-molecular-pathway-in-alleviating-sepsis-induced-lung-injury-via-the-mir-106a-5p-lxn-axis
#37
JOURNAL ARTICLE
Wei He, Chengcheng Xu, Yuying Huang, Qiuzhen Zhang, Wang Chen, Chengkuan Zhao, Yun Chen, Danling Zheng, XinyueLin, Qianhua Luo, Xiaoshan Chen, Zhihan Zhang, Xiaolong Wu, Jianxiang Huang, Chaoxian Lin, Yihui Huang, Shuyao Zhang
This study investigates the molecular mechanisms by which extracellular vesicles (EVs) derived from adipose-derived mesenchymal stem cells (ADSCs) promote M2 polarization of macrophages and thus reduce lung injury caused by sepsis. High-throughput sequencing was used to identify differentially expressed genes related to long non-coding RNA (lncRNA) in ADSC-derived EVs (ADSC-EVs) in sepsis lung tissue. Weighted gene co-expression network analysis (WGCNA) was employed to predict the downstream target genes of the lncRNA DLEU2...
March 4, 2024: International Immunopharmacology
https://read.qxmd.com/read/38442411/deep-learning-promotes-profiling-of-multiple-mirnas-in-single-extracellular-vesicles-for-cancer-diagnosis
#38
JOURNAL ARTICLE
Xue-Wei Zhang, Gong-Xiang Qi, Meng-Xian Liu, Yan-Fei Yang, Jian-Hua Wang, Yong-Liang Yu, Shuai Chen
Extracellular vesicle microRNAs (EV miRNAs) are critical noninvasive biomarkers for early cancer diagnosis. However, accurate cancer diagnosis based on bulk analysis is hindered by the heterogeneity among EVs. Herein, we report an approach for profiling single-EV multi-miRNA signatures by combining total internal reflection fluorescence (TIRF) imaging with a deep learning (DL) algorithm for the first time. This innovative technique allows for the precise characterization of EV miRNAs at the single-vesicle level, overcoming the challenges posed by EV heterogeneity...
March 5, 2024: ACS Sensors
https://read.qxmd.com/read/38434617/the-biological-interplay-between-air-pollutants-and-mirnas-regulation-in-cancer
#39
REVIEW
Alessandro Giammona, Sofia Remedia, Danilo Porro, Alessia Lo Dico, Gloria Bertoli
Air pollution, especially fine particulate matter (PM2.5, with an aerodynamic diameter of less than 2.5 μm), represents a risk factor for human health. Many studies, regarding cancer onset and progression, correlated with the short and/or long exposition to PM2.5. This is mainly mediated by the ability of PM2.5 to reach the pulmonary alveoli by penetrating into the blood circulation. This review recapitulates the methodologies used to study PM2.5 in cellular models and the downstream effects on the main molecular pathways implicated in cancer...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38429100/novel-rna-molecular-bioengineering-technology-efficiently-produces-functional-mirna-agents
#40
JOURNAL ARTICLE
Gavin M Traber, Colleen Yi, Neelu Batra, Meijuan Tu, Aiming Yu
Genome-derived microRNAs (miRNA or miR) govern posttranscriptional gene regulation and play important roles in various cellular processes and disease progression. While chemo-engineered miRNA mimics or biosimilars made in vitro are widely available and used, miRNA agents produced in vivo are emerging to closely recapitulate natural miRNA species for research. Our recent works have demonstrated the success of high-yield, in vivo production of recombinant miRNAs by using human tRNA (htRNA) fused precursor miRNA (pre-miR) carriers...
March 1, 2024: RNA
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