Kevin C Kobylinski, Phornpimon Tipthara, Narenrit Wamaket, Sittinont Chainarin, Rattawan Kullasakboonsri, Patchara Sriwichai, Siriporn Phasomkusolsil, Borimas Hanboonkunupakarn, Podjanee Jittamala, Renia Gemmell, John Boyle, Stephen Wrigley, Jonathan Steele, Nicholas J White, Joel Tarning
Ivermectin mass drug administration to humans or livestock is a potential vector control tool for malaria elimination. The mosquito-lethal effect of ivermectin in clinical trials exceeds that predicted from in vitro laboratory experiments, suggesting that ivermectin metabolites have mosquito-lethal effect. The three primary ivermectin metabolites in humans (i.e., M1 (3″-O-demethyl ivermectin), M3 (4-hydroxymethyl ivermectin), and M6 (3″-O-demethyl, 4-hydroxymethyl ivermectin) were obtained by chemical synthesis or bacterial modification/metabolism...
May 19, 2023: Scientific Reports