Federica Geraci, Roberta Passiatore, Nora Penzel, Samuele Laudani, Alessandro Bertolino, Giuseppe Blasi, Adriana C E Graziano, Gianluca C Kikidis, Ciro Mazza, Madhur Parihar, Antonio Rampino, Leonardo Sportelli, Nicolò Trevisan, Filippo Drago, Francesco Papaleo, Fabio Sambataro, Giulio Pergola, Gian Marco Leggio
Cognitive dysfunctions are core-enduring symptoms of schizophrenia, with important sex-related differences. Genetic variants of the DTBPN1 gene associated with reduced dysbindin-1 protein (Dys) expression negatively impact cognitive functions in schizophrenia through a functional epistatic interaction with Catechol-O-methyltransferase (COMT). Dys is involved in the trafficking of dopaminergic receptors, crucial for prefrontal cortex (PFC) signaling regulation. Moreover, dopamine signaling is modulated by estrogens via inhibition of COMT expression...
March 26, 2024: Molecular Psychiatry