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Caroline Victorri-Vigneau, Jean Benoit Hardouin, Morgane Rousselet, Marie Gerardin, Marylène Guerlais, Morgane Guillou, Marie Bronnec, Véronique Sébille, Pascale Jolliet
AIMS: The French health authority (ANSM) is responsible for monitoring medicinal and other drug dependencies. To support these activities, the ANSM manages a network of 13 drug dependence evaluation and information centres (Centres d'Evaluation et d'Information sur la Pharmacodépendance - Addictovigilance - CEIP-A) throughout France. In 2006, the Nantes CEIP-A created a new tool called the EGAP (Echelle de GrAvité de la Pharmacodépendance- drug dependence severity scale) based on DSM IV criteria...
October 2016: British Journal of Clinical Pharmacology
Koushik Lahiri, Arijit Coondoo
Topical Steroid Damaged/Dependent face (TSDF) is a phenomenon which has been described very recently (2008). It is characterized by a plethora of symptoms caused by an usually unsupervised misuse/abuse/overuse of topical corticosteroid of any potency on the face over an unspecified and/or prolonged period of time. This misuse and damage have a serious effect on the quality of life of the patients in general and the skin of the face in particular. Management is difficult and necessitates psychological counseling as well as physical soothing of the sensitive skin...
May 2016: Indian Journal of Dermatology
Gaëtan Gentile, Elisabeth Frauger, Adeline Giocanti, Vanessa Pauly, Véronica Orleans, Despina Amaslidou, Xavier Thirion, Joëlle Micallef
AIM: The objective of the study is to describe the characteristics of subjects under opiate maintenance treatment by general practionners (GPs). METHOD: Data analysis from observatory for pharmacodependency in ambulatory medicine survey (observation des pharmacodépendances en médecine ambulatoire [OPEMA]) program in 2013 of the subjects under high dosage buprenorphine (HDB) and methadone prescribed or obtained illegally reported by GPs in France. RESULTS: Survey concerned consumers with 862, 433 and 429 of high dosage buprenorphine and respectively methadone...
June 2016: Thérapie
Anne Roussin, Odile Doazan-d'Ouince, Hélène Géniaux, Clémence Halberer
The objective of this paper is to present an evaluation of the potential for abuse of and dependence on a drug from the data obtained from the different pharmacoepidemiological tools used by the French network for evaluation and information on pharmacodependence and addiction monitoring taking the example of tramadol. Comparison of the data from spontaneous reports with surveys in specific populations and with evaluations of indicators of diverted uses does not highlight a major problem of tramadol abuse and dependence in terms of public health, but stresses the importance of paying attention to the signal...
March 2015: Thérapie
Caroline Victorri-Vigneau, Marie Gérardin, Morgane Rousselet, Marylène Guerlais, Marie Grall-Bronnec, Pascale Jolliet
In 2004, the health authorities (French National Agency for Medicines and Health Products Safety-ANSM) modified the summary of zolpidem characteristics. Particularly it now includes the sentence "a pharmacodependence may materialize." The current article aims to show that despite this modification, zolpidem continues to be associated with problematic drug use, as the official system (Center for Evaluation and Information on Pharmacodependence-Addictovigilance network) providing information on the abuse and dependence potential of drugs informs us...
2014: Journal of Addictive Diseases
Caroline Victorri-Vigneau, F Feuillet, L Wainstein, M Grall-Bronnec, J Pivette, A Chaslerie, V Sébille, P Jolliet
PURPOSE: Zolpidem and zopiclone are two widely used non-benzodiazepine hypnotics whose usage seems to be associated to pharmacodependence. However, to our knowledge, there has as yet been no published epidemiological study which has compared their abuse or dependence potential. We used a pharmacoepidemiological approach to identify and characterise zolpidem and zopiclone users in real life situations. METHODS: Regular users of zolpidem or zopiclone were identified in the database of a French regional health insurance organisation...
November 2013: European Journal of Clinical Pharmacology
Christophe Moracchini, Veronica Orleans, Samira Miloudi, Elisabeth Frauger, Joëlle Micallef, Xavier Thirion
Aim. This study presents the OPEMA (Observation des pharmacodépendances en médecine ambulatoire) programme and the main results of its last annual survey (november 2010). Method. Collected data concern mainly subjects' sociodemographic situation, their state of health and their current consumption of psychoactive substance. Results. In 2010, 1394 subjects have been included, describing 2 450 consumptions of psychoactive susbtance. Their mean age is 38,2±12,7 years. Eighty-six per cent have a stable accomodation and 52% are in employment...
July 2012: Thérapie
Caroline Victorri-Vigneau, Laura Wainstein, Jean-Yves Guillet, Marie Gérardin, Pascale Jolliet
UNLABELLED: The aim of our study is to evaluate the extent of agreement between pharmacodependence to benzodiazepines, as diagnosed by doctors and as self evaluated by patients, using DSM-IV dependence criteria. Method. This is a prospective study. INCLUSION CRITERIA: prescription of a benzodiazepines or related substances. DATA COLLECTION: doctor questionnaire and patient questionnaire filled anonymously and independently. Main judgment criterion: rate of agreement between doctor diagnosis (is this patient dependent?), and patient evaluation (dependence is positive if at least 3 of the DSM-IV items are met)...
March 2012: Thérapie
M-G Landreat, C Victorri Vigneau, M Grall Bronnec, V Sebille-Rivain, J-L Venisse, P Jolliet
INTRODUCTION: Lots of similar vulnerabilities to substance use disorders are described in the literature: clinical, genetics, family, environment, etc. Although, when we follow up patients, we know perfectly well that there are also differences due to the substance mainly causing addiction. But we found very little research on the differences between various substance use disorders according to the substance mainly causing dependence. HYPOTHESIS: Our main hypothesis was that significant differences do not exist in medical and social data between patients with substance use disorders according to the substance mainly used...
December 2011: L'Encéphale
Caroline Victorri-Vigneau, Véronique Sébille, Marie Gérardin, Dominique Simon, Jacques Pivette, Pascale Jolliet
The authors present a pharmaco-epidemiological method for the characterization of drug overconsumption. Using the database of a French regional health insurance office, a comparison was made between patients receiving doses higher than recommended and all patients receiving normal doses of two antidepressant drugs (tianeptine and milnacipran). Logistic regression models were used to identify the variables related to overconsumption. The selected variables were different for each antidepressant and provided a good characterization of overconsumption features: insufficient effectiveness and severity of the condition for milnacipran and abuse/misuse for tianeptine...
October 2011: Journal of Addictive Diseases
(no author information available yet)
Between 2000 and 2008, the American Association of Poison Control Centers recorded 1439 cases in which drugs or alcohol were used to mistreat children under 7 years of age, representing an average of 160 reports per year. Median age was 2 years, and 57% of victims were boys. The substances included psychotropic drugs, analgesics, cold remedies, alcohol, and illicit drugs. 18 children died, while 32 children experienced life-threatening effects or residual disability. It is not clear whether these results can be extrapolated to the French population...
October 2011: Prescrire International
Elisabeth Frauger, Vanessa Pauly, Vincent Pradel, Frank Rouby, Jocelyne Arditti, Xavier Thirion, Maryse Lapeyre Mestre, Joëlle Micallef
Recent observations suggest the existence of clonazepam abuse. To determine its importance in France, a quantitative and systematic synthesis of all clonazepam data of several epidemiological tools of the Centers for Evaluation and Information on Pharmacodependence (CEIP) network has been performed in comparison with data on others benzodiazepines (BZD). Data on clonazepam and other BZD have been analysed from different epidemiological tools: OSIAP survey that identifies drugs obtained by means of falsified prescriptions, Observation of Illegal Drugs and Misuse of Psychotropic Medications (OPPIDUM) survey that describes modalities of use and data from regional French health reimbursement system...
October 2011: Fundamental & Clinical Pharmacology
Gaëlle Julians-Minou, Sarah Bruch, Nathalie Peyre, Guillaume Sudérie, Maryse Lapeyre-Mestre, Anne Roussin
OBJECTIVE: To describe the evolution of buprenorphine prescription form characteristics before and after the application of a measure of the French Social Security system aimed to encourage the use of generic drugs. METHOD: All buprenorphine prescription forms issued to sixty-two patients subjected to follow-up in 6 community pharmacies were analysed between October 2007 and February 2008. RESULTS: Patients maintained on Subutex during the whole follow-up were more numerous (n=39), younger, and received a higher daily dose of buprenorphine (10...
May 2010: Thérapie
V Pauly, E Frauger, F Rouby, S Sirere, S Monier, C Paulet, V Gibaga, J Micallef, X Thirion
INTRODUCTION: The data on consumption of psychoactive substances among new prisoners are documented but not detailed with precision. Nevertheless, analyzing the consumption's characteristics of psychoactive products would led to a better caring of subjects at the entry in the prison. The consumption of psychoactive drugs the week before the imprisonments of subjects seen in prison were studied from the Observation of Illegal Drugs and Misuse of Psychotropic Medications (OPPIDUM) program's between 2003 and 2006...
April 2010: L'Encéphale
Nicolas Authier, Alexandra Boucher, Dominique Lamaison, Pierre-Michel Llorca, Jacques Descotes, Alain Eschalier
The aim of this meeting was to describe the news trends about abuse and addiction of anxiolytics and hypnotics. The part II of this meeting reviewed several aspects of the withdrawing benzodiazepines focusing in particular on clinical symptoms, biological patterns, and strategies for discontinuation. The discontinuation is usually beneficial due to the importance of adverse effects induced by long-term use of benzodiazepines. Several clinicals options have been described including gradual tapering of the current benzodiazepine, substitution with a long acting benzodiazepines or treating the symptoms of withdrawal...
November 2009: Thérapie
Joëlle Micallef-Roll, Maryse Lapeyre-Mestre
The second meeting of the French CEIP (Centres d'Evaluation et d'Information sur la Pharmacodépendance) was organized during the annual congress of the French Society of Pharmacology Therapeutics and Physiology in 2008. The aim of this meeting was to update the knowledge on abuse and dependence of the anxiolytics and hypnotics from different points of view (pharmacoepidemiology, epidemiology and treatment). The first part of this meeting summarized the pharmacological data obtained by the pharmacoepidemiological tools developed by the CEIP network...
November 2009: Thérapie
Frédérique Beau-Salinas, Annie Pierre Jonville-Béra, Haware Cissoko, Lamiae Bensouda-Grimaldi, Elisabeth Autret-Leca
INTRODUCTION: The aim of this case/non-case study was to assess and compare the risk of drug dependence associated with different migraine-specific drugs, i.e., ergot derivatives and triptans, using the French pharmacovigilance database. METHODS: Reports on drug side effects recorded in this database between January 1985 and June 2007 were analyzed, and triptans (almotriptan, eletriptan, naratriptan, sumatriptan, and zolmitriptan) as well as ergot derivatives used in acute migraine were examined...
April 2010: European Journal of Clinical Pharmacology
Caroline Victorri-Vigneau, Katia Larour, Dominique Simon, Jacques Pivette, Pascale Jolliet
GOAL: Make it possible to spot falsified prescriptions which were delivered and reimbursed. METHOD: 1- Use health insurance administration data bases to single patients liable to suspicion of fraud (repeated presentations of the same prescription to several pharmacies the same day) 2- Attribution of a diagnosis of fraud, by the CEIP (Center of Evaluation and Information about Pharmacodependence) based on transferred data, and by the medical department analysis of the complete file, and convocation when applicable 3- Calculation of quantitative performance of the tool...
January 2009: Thérapie
S Djezzar, F Questel, E Burin, S Dally
Psychoactive substances may be administered without the knowledge of a victim in order to induce incapacitation and thus facilitate criminal actions. The characteristics of the victims and the drugs used in such suspected chemical submissions (CS) were analyzed in 309 cases collected from October 2003 to December 2007 through a national survey. Out of 309 cases, 158 met all criteria of CS. The victims were mostly female (n = 89, 56%). The type of aggression was mostly sexual assault (in 79 cases 50%). Benzodiazepines and related drugs were detected in 129 victims (82%) and were mostly clonazepam, zolpidem, and bromazepam whereas flunitrazepam and gamma hydroxybutyrate, well known for their use in CS, were identified in 11 (7%) and five (3%) of the 158 victims...
May 2009: International Journal of Legal Medicine
Joëlle Micaleff, Pascale Jolliet, Caroline Victorri-Vigneau, Michel Mallaret, Nathalie Richard, Françoise Haramburu, Maryse Lapeyre-Mestre
The French system for the evaluation of abuse and dependence created in 1990 was definitely implemented in 1999 with the decree no99-249 making in particular mandatory the reporting of all serious cases of abuse or dependence to psychoactive drugs. This decree was also important to define the role of each party (regulatory agencies, pharmaceutical companies, health professionals and the network of the regional Centres for Evaluation and Information of Pharmacodependence) for all marketed psychoactive drugs in France...
January 2008: Thérapie
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