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JOURNAL ARTICLE
Vivianne B C Kokje, Gabor Gäbel, Ron L Dalman, Dave Koole, Bernd H Northoff, Lesca M Holdt, Jaap F Hamming, Jan H N Lindeman
There are indications for elevated CXCL8 levels in abdominal aortic aneurysm disease (AAA). CXCL8 is concurrently involved in neutrophil-mediated inflammation and angiogenesis, two prominent and distinctive characteristics of AAA. As such we considered an evaluation of a role for CXCL8 in AAA progression relevant. ELISA's, real time PCR and array analysis were used to explore CXCL8 signaling in AAA wall samples. A role for CXCL8 in AAA disease was tested through the oral CXCR1/2 antagonist DF2156A in the elastase model of AAA disease...
August 2018: Cytokine
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Ron Fairman, Ronald Dalman, Jon Matsumura
No abstract text is available yet for this article.
June 2014: Journal of Vascular Surgery
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