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peripheric vascular disease

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https://www.readbyqxmd.com/read/28432005/radial-ulnar-angioplasty-in-selected-patients-undergoing-elective-angiography-or-pci-using-complex-forearm-approach
#1
Santiago Jesús Camacho Freire, Antonio Enrique Gómez Menchero, Javier León Jiménez, Jessica Roa Garrido, Rosa Cardenal Piris, José Francisco Díaz Fernández
BACKGROUND: Angioplasty on the radial artery have been performed with good success rates in patients with critical hand ischemia. We sought to assess the feasibility and safety of radial angioplasty on complex radial access in patients undergoing coronary angiography. METHODS/MATERIAL: A prospective series of procedures with complex radial/ulnar access to which radial-ulnar angioplasty (RU-A) was performed. We set goals of efficacy and safety that included the success rate of the procedure (need for ¨Crossover femoral¨) and the existence of radial pulse at one month...
April 11, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28430012/zo-1-expression-is-suppressed-by-gm-csf-via-mir-96-erg-in-brain-microvascular-endothelial-cells
#2
Hu Zhang, Shuhong Zhang, Jilin Zhang, Dongxin Liu, Jiayi Wei, Wengang Fang, Weidong Zhao, Yuhua Chen, Deshu Shang
The level of granulocyte-macrophage colony-stimulating factor (GM-CSF) increases in some disorders such as vascular dementia, Alzheimer's disease, and multiple sclerosis. We previously reported that in Alzheimer's disease patients, a high level of GM-CSF in the brain parenchyma downregulated expression of ZO-1, a blood-brain barrier tight junction protein, and facilitated the infiltration of peripheral monocytes across the blood-brain barrier. However, the molecular mechanism underlying regulation of ZO-1 expression by GM-CSF is unclear...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28429868/clarification-of-serotonin-induced-effects-in-peripheral-artery-disease-observed-through-the-femoral-artery-response-in-models-of-diabetes-and-vascular-occlusion-the-role-of-calcium-ions
#3
Marko Stojanović, Milica Prostran, Radmila Janković, Miroslav Radenković
Recent findings have demonstrated that serotonin is an important participant in the development and progression of peripheral artery diseases. Taking this into consideration, the goals of this study were to investigate the effects of serotonin on isolated Wistar rat femoral arteries in both healthy and diabetic animals, with and without artery occlusion, with a particular focus on determining the role of calcium in this process. Contraction experiments with serotonin on intact and denuded femoral artery rings, in the presence or absence of nifedipine and ouabain (both separately, or in combination), as well as Ca(2+) -free Krebs-Ringer bicarbonate solution were performed...
April 21, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28427823/journey-of-hybrid-procedures-in-peripheral-vascular-diseases
#4
Ajay Kumar Dabas, Rishi Dhillan, Raghvinder Pal Singh Gambhir
No abstract text is available yet for this article.
April 17, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28426572/nonhealing-ulcers-in-patients-with-tophaceous-gout-a-systematic-review
#5
Gretl Lam, Frank L Ross, Ernest S Chiu
GENERAL PURPOSE: To provide information from a review of the literature about chronic ulcers associated with tophaceous gout. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After participating in this educational activity, the participant should be better able to:1. Identify the pathophysiology of tophaceous gout, its presentation, phases, and common comorbidities...
May 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28424377/sex-differences-in-micro-and-macro-vascular-complications-of-diabetes-mellitus
#6
REVIEW
Christine Maric-Bilkan
Vascular complications are a leading cause of morbidity and mortality in both men and women with type 1 (T1DM) or type 2 (T2DM) diabetes mellitus, however the prevalence, progression and pathophysiology of both microvascular (nephropathy, neuropathy and retinopathy) and macrovascular [coronary heart disease (CHD), myocardial infarction, peripheral arterial disease (PAD) and stroke] disease are different in the two sexes. In general, men appear to be at a higher risk for diabetic microvascular complications, while the consequences of macrovascular complications may be greater in women...
May 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28423914/current-views-on-neuropeptide-y-and-diabetes-related-atherosclerosis
#7
Wei-Wei Sun, Ping Zhu, Yan-Chuan Shi, Chen-Liang Zhang, Xu-Feng Huang, Shi-Yu Liang, Zhi-Yuan Song, Shu Lin
Diabetes-induced atherosclerotic cardiovascular disease is the leading cause of death of diabetic patients. Neuronal regulation plays a critical role in glucose metabolism and cardiovascular function under physiological and pathological conditions, among which, neurotransmitter neuropeptide Y has been shown to be closely involved in these two processes. Elevated central neuropeptide Y level promotes food intake and reduces energy expenditure, thereby increasing adiposity. Neuropeptide Y is co-localized with noradrenaline in central and sympathetic nervous systems...
April 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28423345/homocysteine-induced-peripheral-microcirculation-dysfunction-in-zebrafish-and-its-attenuation-by-l-arginine
#8
Sang Joon Lee, Sung Ho Park, Jinhyuk Fred Chung, Woorak Choi, Hyung Kyu Huh
Elevated blood homocysteine (Hcy) level is frequently observed in aged individuals and those with age-related vascular diseases. However, its effect on peripheral microcirculation is still not fully understood. Using in vivo zebrafish model, the degree of Hcy-induced peripheral microcirculation dysfunction is assessed in this study with a proposed dimensionless velocity parameter V¯CV/V¯PCV, where V¯CV and V¯PCV represent the peripheral microcirculation perfusion and the systemic perfusion levels, respectively...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422344/use-of-blood-pool-agents-with-steady-state-mri-to-assess-the-vascular-system
#9
Avnesh S Thakor, John Chung, Premal Patel, Anthony Chan, Amdad Ahmed, Graeme McNeil, David M Liu, Bruce Forster, Darren Klass
Over the past two decades there have been significant advances in the use of magnetic resonance imaging (MRI) to assess the vascular system. New imaging sequences and improvements in magnet design have enabled the creation of higher spatial resolution images. MRI is now a viable alternative imaging modality when compared to both invasive angiography and computed tomographic angiography. The use of blood pool agents has further facilitated the use of MR angiography (MRA); their high molecular weight allows for lower doses of contrast medium administration while their prolonged presence in the blood stream allows for repeated high-quality volumetric imaging of both the arterial and venous circulation...
April 19, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28422124/prevalence-of-type-2-diabetes-and-its-complications-in-india-and-economic-costs-to-the-nation
#10
REVIEW
R Pradeepa, V Mohan
Diabetes, a major lifestyle disorder, has become a global burden, and the prevalence rates are rising steeply in developing economies. Rapid socioeconomic transition with urbanization and industrialization are the main causes for the global diabetes epidemic. Among developing economies, the highest increase in number of people with diabetes is in China followed by India. In India, the epidemic of diabetes continue to increase and is experiencing a shift in diabetes prevalence from urban to rural areas, the affluent to the less privileged and from older to younger people...
April 19, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28416142/nanoparticle-mediated-drug-delivery-system-for-atherosclerotic-cardiovascular-disease
#11
REVIEW
Tetsuya Matoba, Jun-Ichiro Koga, Kaku Nakano, Kensuke Egashira, Hiroyuki Tsutsui
Administration of drugs and other therapeutic agents has been the central strategy of contemporary medicine for cardiovascular disease. The use of drug delivery systems (DDS) includes micelles, liposomes, polymeric nanoparticles, dendrimers, carbon nanotubes, and crystalline metals. Nano-DDS modify in vivo drug kinetics, depending on (patho)physiological mechanisms such as retard excretion, vascular permeability, and incorporation by mononuclear phagocyte systems, which constitute the 'passive-targeting' property of nano-DDS...
April 13, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28414714/excess-atherosclerosis-in-systemic-lupus-erythematosus-a-matter-of-renal-involvement-case-control-study-of-281-sle-patients-and-281-individually-matched-population-controls
#12
Johanna T Gustafsson, Marie Herlitz Lindberg, Iva Gunnarsson, Susanne Pettersson, Kerstin Elvin, John Öhrvik, Anders Larsson, Kerstin Jensen-Urstad, Elisabet Svenungsson
BACKGROUND: Systemic lupus erythematosus (SLE), is a heterogeneous disease which predominantly affects young females (90%). SLE is associated with a shorter life expectancy than in the general population. Standardized mortality ratios (SMR) of 2.4 have been reported, which is comparable to diabetes. In modern societies cardiovascular disease (CVD) is the major cause of premature mortality. Accelerated atherosclerosis is generally assumed to be the underlying cause for SLE related CVD...
2017: PloS One
https://www.readbyqxmd.com/read/28412915/early-functional-and-structural-microvascular-changes-in-hypertension-related-to-aging
#13
Roger de Moraes, Eduardo Tibirica
It is becoming increasingly clear that both microvascular network alterations and subsequent tissue perfusion defects may precede and predict the development of arterial hypertension and other cardiovascular and metabolic diseases, including diabetes and metabolic syndrome. Moreover, the subsequent functional and structural alterations in microvascular reactivity and density, as well as alterations in the macrocirculation characteristic of physiologic vascular aging, contribute to the development of target organ damage...
April 12, 2017: Current Hypertension Reviews
https://www.readbyqxmd.com/read/28412700/takayasu-arteritis-and-spondyloarthritis-coincidence-or-association-a-study-of-14-cases
#14
Elodie Rivière, Laurent Arnaud, Mikael Ebbo, Yannick Allanore, Pascal Claudepierre, Emmanuelle Dernis, Jean-Marc Ziza, Corinne Miceli-Richard, Peggy Philippe, Christophe Richez, Martin Soubrier, Rakiba Belkhir, Raphaèle Seror, Xavier Mariette, Stephan Pavy
OBJECTIVE: Spondyloarthritis (SpA) and Takayasu arteritis (TA) are 2 chronic inflammatory diseases; their coexistence in a single patient is uncommon. The aims of our study were to describe clinical features of patients having SpA associated with TA and to identify some characteristics of the types of patients with SpA associated with TA. We also analyzed treatments used in this context. METHODS: This French multicenter retrospective survey called for observations on behalf of the Club Rhumatismes et Inflammations, with a standardized questionnaire established by the investigators...
April 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28412277/the-association-of-endothelial-function-and-tone-by-digital-arterial-tonometry-with-mri-left-ventricular-mass-in-african-americans-the-jackson-heart-study
#15
Avnish Tripathi, Emelia J Benjamin, Solomon K Musani, Naomi M Hamburg, Connie W Tsao, Arti Saraswat, Ramachandran S Vasan, Gary F Mitchell, Ervin R Fox
Peripheral vascular endothelial dysfunction assessed by digital peripheral arterial tonometry (PAT) has been associated with risk for adverse cardiovascular events. We examined the relations of peripheral microvascular dysfunction and left ventricular mass in a community-based cohort of African Americans. We examined participants of the Jackson Heart Study who had PAT and cardiac magnetic resonance imaging evaluations between 2007 and 2013. Consistent with pertinent literature, left ventricular mass index (LVMI) was adjusted for body size by indexing to height(2...
March 27, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28411089/evidence-for-polymicrobial-communities-in-explanted-vascular-filters-and-atheroma-debris
#16
Jeremy E Ellis, Richard Heuser, Dara S Missan, Delyn Martinez, Avory Heningburg, Matthew Shabilla, Renata Schwartz, Stephen Fry
RATIONALE: Microbial communities have been implicated in a variety of disease processes and have been intermittently observed in arterial disease; however, no comprehensive unbiased community analysis has been performed. We hypothesize that complex microbial communities may be involved in chronic vascular diseases as well and may be effectively characterized by molecular assays. OBJECTIVE: The main objective is to survey vascular debris, atheroma, and vascular filters for polymicrobial communities consisting of prokaryotic and eukaryotic microbes, specifically eukaryotic microbes...
April 11, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28411075/effect-of-gender-and-adiposity-on-in%C3%A2-vivo-vascular-function-in-young-african-americans
#17
Namrata Dass, Sindhu Kilakkathi, Brittaney Obi, Andrea Moosreiner, Shanthi Krishnaswami, Michael E Widlansky, Srividya Kidambi
The relationship between obesity and high blood pressure is not as strong among African Americans (AA) as compared to Caucasians. We designed the current study to determine the effect of adiposity on vascular endothelial function (a harbinger of hypertension) among young healthy AA without additional cardiovascular disease risk factors. A total of 108 AA subjects (46 women) between the ages of 18 and 45 years were recruited. All the subjects were normotensive, nonsmokers, and normoglycemic. Anthropometric and cardiovascular disease risk factor measurements (lipid, insulin resistance, and inflammatory markers) were obtained...
March 14, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28410927/younger-onset-versus-older-onset-type-2-diabetes-clinical-profile-and-complications
#18
Ranjit Unnikrishnan, Ranjit Mohan Anjana, Anandakumar Amutha, Harish Ranjani, Saravanan Jebarani, Mohammed K Ali, K M Venkat Narayan, Viswanathan Mohan
AIMS: To compare the clinical profile and complications between younger and older onset type 2 diabetes (T2DM) patients at a tertiary care diabetes center in south India. METHODS: We compared individuals with T2DM detected at age ≤25years (n=267) and at age≥50years (n=267), matched for gender and duration of diabetes. We reviewed electronic patient charts and extracted data on biochemical parameters (plasma glucose, serum lipids and glycated hemoglobin). We estimated prevalence of complications (retinopathy, nephropathy, neuropathy, and peripheral vascular disease)...
March 23, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28410504/exercise-training-in-older-adults-what-effects-on-muscle-oxygenation-a-systematic-review
#19
REVIEW
Elie Fiogbé, Verena de Vassimon-Barroso, Anielle Cristhine de Medeiros Takahashi
AIM: To determine the effects of different modality of exercise training programs on muscle oxygenation in older adults. METHODS: Relevant articles were searched in PubMed, Web of Science, Science Direct and Scopus, using the keywords: "Aged" AND "Muscle oxygenation" AND (Exercise OR "Exercise therapy" OR "Exercise Movement Techniques" OR Hydrotherapy), without limitation concerning the publication date. To be included in the full analysis, the study had to be a randomized controlled trial in which older adults participants (mean age: 65 years at least) were submitted to an exercise-training program and muscle oxygenation assessment...
March 20, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28405488/multiple-intravitreal-ranibizumab-injections-for-persistant-choroidal-neovascularization-associated-with-presumed-ocular-histoplasmosis-syndrome
#20
Turgut Yılmaz, Seyhan Dikci, Oğuzhan Genç, Kayhan Mutlu
Presumed ocular histoplasmosis syndrome (POHS) is a clinical entity that is characterized by small, round, discrete, macular or mid peripheral atrophic (punched out) chorioretinal lesions (histo spots), peripapillary scarring, choroidal neovascularization (CNV), and the absence of anterior uveitis and vitritis. Diagnosis of this disorder is based upon characteristic clinical findings and a positive histoplasmin skin test or residence in an endemic region for Histoplasma capsulatum. There is no active systemic disease during diagnosis of POHS...
April 2017: Turkish Journal of Ophthalmology
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