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B. timothy baxter

Matthew A Dale, Wanfen Xiong, Jeffrey S Carson, Melissa K Suh, Andrew D Karpisek, Trevor M Meisinger, George P Casale, B Timothy Baxter
Abdominal aortic aneurysm is a dynamic vascular disease characterized by inflammatory cell invasion and extracellular matrix degradation. Damage to elastin in the extracellular matrix results in release of elastin-derived peptides (EDPs), which are chemotactic for inflammatory cells such as monocytes. Their effect on macrophage polarization is less well known. Proinflammatory M1 macrophages initially are recruited to sites of injury, but, if their effects are prolonged, they can lead to chronic inflammation that prevents normal tissue repair...
June 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Prateek K Gupta, Bala Ramanan, Leonid Grossman, Himani Gupta, Xiang Fang, Jason N MacTaggart, Thomas G Lynch, B Timothy Baxter, Iraklis I Pipinos
BACKGROUND: Literature on postoperative outcomes following aortic surgery for aortic graft infection (AGI) is limited by relatively small sample sizes, resulting in lack of national benchmarks for quality of care. We report in-hospital outcomes following abdominal aortic surgery for AGI and identify factors associated with postoperative complications using the Nationwide Inpatient Sample (NIS) database. METHODS: Patients who underwent aortic graft resection for AGI were identified from the 2002 to 2008 NIS database, a multicenter database capturing 20% of all US admissions...
May 2016: Vascular and Endovascular Surgery
Dale L Phelps, Robert M Ward, Rick L Williams, Tracy L Nolen, Kristi L Watterberg, William Oh, Michael Goedecke, Richard A Ehrenkranz, Timothy Fennell, Brenda B Poindexter, C Michael Cotten, Mikko Hallman, Ivan D Frantz, Roger G Faix, Kristin M Zaterka-Baxter, Abhik Das, M Bethany Ball, Conra Backstrom Lacy, Michele C Walsh, Waldemar A Carlo, Pablo J Sánchez, Edward F Bell, Seetha Shankaran, David P Carlton, Patricia R Chess, Rosemary D Higgins
BACKGROUND: Preterm infants with respiratory distress syndrome (RDS) given inositol had reduced bronchopulmonary dysplasia (BPD), death and severe retinopathy of prematurity (ROP). We assessed the safety and pharmacokinetics of daily inositol to select a dose providing serum levels previously associated with benefit, and to learn if accumulation occurred when administered throughout the normal period of retinal vascularization. METHODS: Infants ≤ 29 wk GA (n = 122, 14 centers) were randomized and treated with placebo or inositol at 10, 40, or 80 mg/kg/d...
2016: Pediatric Research
B Timothy Baxter, Jon Matsumura, John Curci, Ruth McBride, William C Blackwelder, Xinggang Liu, LuAnn Larson, Michael L Terrin
OBJECTIVES: The Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA(3)CT) is a Phase IIb randomized, placebo-controlled clinical trial, testing doxycycline (100mg bid) for inhibition of growth in the greatest transverse, orthogonal diameter of small abdominal aortic aneurysms (AAA). METHODS: We will enroll 258 patients, ≥55years of age who have AAA, men: 3.5-5.0cm and women: 3.5-4.5cm on CT scans confirmed centrally. The primary outcome is growth in maximal transverse, orthogonal diameter from baseline to 24-month follow-up...
May 2016: Contemporary Clinical Trials
Weston William Keller, Dimitrios Miserlis, Melissa Suh, Matthew Dale, Samer Sayyed, B Timothy Baxter
Renal arteriovenous fistulas (AVFs) are an uncommon complication of nephrectomy. In this report, we present the case of a 66-year-old female presenting with progressive dyspnea on exertion and exercise intolerance. She was diagnosed and treated for adult onset reactive airway disease. The patient underwent nephrectomy at age 18 secondary to recurrent pyelonephritis from vesicoureteral reflux. She underwent a surveillance computed tomography (CT) scan to evaluate a small ascending aneurysm that was initially detected on cardiac echocardiogram...
January 2016: Vascular and Endovascular Surgery
Matthew A Dale, Melissa K Suh, Shijia Zhao, Trevor Meisinger, Linxia Gu, Vicki J Swier, Devendra K Agrawal, Timothy C Greiner, Jeffrey S Carson, B Timothy Baxter, Wanfen Xiong
OBJECTIVE: Evidence has demonstrated profound influence of genetic background on cardiovascular phenotypes. Murine models in Marfan syndrome (MFS) have shown that genetic background-related variations affect thoracic aortic aneurysm formation, rupture, and lifespan of mice. MFS mice with C57Bl/6 genetic background are less susceptible to aneurysm formation compared to the 129/SvEv genetic background. In this study, we hypothesize that susceptibility to abdominal aortic aneurysm (AAA) will be increased in 129/SvEv mice versus C57Bl/6 mice...
December 2015: Atherosclerosis
Matthew A Dale, Melissa K Ruhlman, B Timothy Baxter
Abdominal aortic aneurysms (AAAs) are characterized by chronic inflammatory cell infiltration. AAA is typically an asymptomatic disease and caused ≈15 000 deaths annually in the United States. Previous studies have examined both human and murine aortic tissue for the presence of various inflammatory cell types. Studies show that in both human and experimental AAAs, prominent inflammatory cell infiltration, such as CD4(+) T cells and macrophages, occurs in the damaged aortic wall. These cells have the ability to undergo phenotypic modulation based on microenvironmental cues, potentially influencing disease progression...
August 2015: Arteriosclerosis, Thrombosis, and Vascular Biology
Jeffrey S Carson, Wanfen Xiong, Matthew Dale, Fang Yu, Michael J Duryee, Daniel R Anderson, Geoffrey M Thiele, B Timothy Baxter
OBJECTIVE: Abdominal aortic aneurysm (AAA) is a pathologic dilation of the aorta. Inflammation of the aortic wall has been shown to be involved in AAA formation. Malondialdehyde-acetaldehyde (MAA) adducts are MAA/protein hybrids with immunogenic, proinflammatory, and profibrotic properties. Levels of MAA adducts are elevated in patients with coronary artery disease; however, the role of MAA adducts in AAA is unclear. We hypothesize that levels of circulating antibodies against MAA adducts are increased in patients with AAA...
February 2016: Journal of Vascular Surgery
Alexey V Kamenskiy, Iraklis I Pipinos, Jeffrey S Carson, Jason N MacTaggart, B Timothy Baxter
BACKGROUND: Carotid artery geometry has been suggested as a risk factor for atherosclerotic carotid artery disease (ACD). Although normal aging and development of disease can both lead to geometric changes in the artery, whether geometric changes in a given artery actually predispose to disease or are just a consequence of remodeling during aging is unclear. We investigated carotid artery geometric changes with aging to identify geometric features associated with the presence of ACD. METHODS: Carotid artery geometry was quantified by measuring carotid artery diameter, tortuosity, and bifurcation angle using three-dimensional reconstructions of thin-section computed tomography angiography scans in 15 healthy individuals (average age, 43 ± 18 years; range, 15-64 years)...
December 2015: Journal of Vascular Surgery
Jason N MacTaggart, Nicholas Y Phillips, Carol S Lomneth, Iraklis I Pipinos, Robert Bowen, B Timothy Baxter, Jason Johanning, G Matthew Longo, Anastasia S Desyatova, Michael J Moulton, Yuris A Dzenis, Alexey V Kamenskiy
High failure rates of femoropopliteal artery reconstruction are commonly attributed to complex 3D arterial deformations that occur with limb movement. The purpose of this study was to develop a method for accurate assessment of these deformations. Custom-made stainless-steel markers were deployed into 5 in situ cadaveric femoropopliteal arteries using fluoroscopy. Thin-section CT images were acquired with each limb in the straight and acutely bent states. Image segmentation and 3D reconstruction allowed comparison of the relative locations of each intra-arterial marker position for determination of the artery's bending, torsion and axial compression...
July 18, 2014: Journal of Biomechanics
Dale L Phelps, Robert M Ward, Rick L Williams, Kristi L Watterberg, Abbot R Laptook, Lisa A Wrage, Tracy L Nolen, Timothy R Fennell, Richard A Ehrenkranz, Brenda B Poindexter, C Michael Cotten, Mikko K Hallman, Ivan D Frantz, Roger G Faix, Kristin M Zaterka-Baxter, Abhik Das, M Bethany Ball, T Michael O'Shea, Conra Backstrom Lacy, Michele C Walsh, Seetha Shankaran, Pablo J Sánchez, Edward F Bell, Rosemary D Higgins
BACKGROUND: Myo-inositol given to preterm infants with respiratory distress has reduced death, increased survival without bronchopulmonary dysplasia, and reduced severe retinopathy of prematurity in two randomized trials. Pharmacokinetic (PK) studies in extremely preterm infants are needed before efficacy trials. METHODS: Infants born in 23-29 wk of gestation were randomized to a single intravenous (i.v.) dose of inositol at 60 or 120 mg/kg or placebo. Over 96 h, serum levels (sparse sampling population PK) and urine inositol excretion were determined...
December 2013: Pediatric Research
Bala Ramanan, Prateek K Gupta, Abhishek Sundaram, Thomas G Lynch, Jason N MacTaggart, B Timothy Baxter, Jason M Johanning, Iraklis I Pipinos
OBJECTIVE: Recent single-center reports demonstrate a high (up to 10%) incidence of postoperative venous thromboembolism (VTE) after major vascular surgery. Moreover, vascular patients rarely receive prolonged prophylaxis despite evidence that it reduces thromboembolic events after discharge. This study used a national, prospective, multicenter database to define the incidence of overall and postdischarge VTE after major vascular operations and assess risk factors associated with VTE development...
June 2013: Journal of Vascular Surgery
Sameer A Greenall, John D Bentley, Lesley A Pearce, Judith A Scoble, Lindsay G Sparrow, Nicola A Bartone, Xiaowen Xiao, Robert C Baxter, Leah J Cosgrove, Timothy E Adams
Insulin-like growth factor II (IGF-II) is a major embryonic growth factor belonging to the insulin-like growth factor family, which includes insulin and IGF-I. Its expression in humans is tightly controlled by maternal imprinting, a genetic restraint that is lost in many cancers, resulting in up-regulation of both mature IGF-II mRNA and protein expression. Additionally, increased expression of several longer isoforms of IGF-II, termed "pro" and "big" IGF-II, has been observed. To date, it is ambiguous as to what role these IGF-II isoforms have in initiating and sustaining tumorigenesis and whether they are bioavailable...
January 4, 2013: Journal of Biological Chemistry
Evelyn Torsney, Grisha Pirianov, Nicoletta Charolidi, Azza Shoreim, David Gaze, Slaveia Petrova, Ken Laing, Trevor Meisinger, Wanfen Xiong, B Timothy Baxter, Gillian W Cockerill
OBJECTIVE: Patients with abdominal aortic aneurysms have lower concentrations of high-density lipoproteins (HDLs), leading us to investigate whether increasing plasma HDLs could influence aneurysm formation. METHODS AND RESULTS: Using the angiotensin II-induced hypercholesterolemic and the CaCl(2)-induced normocholesterolemic mouse model of AAA, we investigated the hypothesis that elevation of HDLs inhibits AAA. HDLs elevated before or at the time of AAA induction reduced AAA formation in both models but had no effect on early ruptures...
November 2012: Arteriosclerosis, Thrombosis, and Vascular Biology
Wanfen Xiong, Trevor Meisinger, Rebecca Knispel, Jennifer M Worth, B Timothy Baxter
RATIONALE: Aneurysm and dissection of the ascending thoracic aorta are the main cardiovascular complications of Marfan syndrome (MFS) resulting in premature death. Studies using mouse models of MFS have shown that activation of transforming growth factor-beta (TGF-β) and the concomitant upregulation of matrix metalloproteinases (MMPs) contribute to aneurysm development. Our previous study showed that doxycycline delayed aneurysm rupture in a mouse model of MFS, Fbn1(mgR/mgR). Losartan has been shown to prevent aneurysms in another mouse model of MFS, Fbn1(C1039G/+), through inhibition of the Erk1/2 pathway...
June 8, 2012: Circulation Research
Ryoko Shimizu-Hirota, Wanfen Xiong, B Timothy Baxter, Steven L Kunkel, Ivan Maillard, Xiao-Wei Chen, Farideh Sabeh, Rui Liu, Xiao-Yan Li, Stephen J Weiss
Macrophages play critical roles in events ranging from host defense to obesity and cancer, where they infiltrate affected tissues and orchestrate immune responses in tandem with the remodeling of the extracellular matrix (ECM). Despite the dual roles played by macrophages in inflammation, the functions of macrophage-derived proteinases are typically relegated to tissue-invasive or -degradative events. Here we report that the membrane-tethered matrix metalloenzyme MT1-MMP not only serves as an ECM-directed proteinase, but unexpectedly controls inflammatory gene responses wherein MT1-MMP(-/-) macrophages mount exaggerated chemokine and cytokine responses to immune stimuli both in vitro and in vivo...
February 15, 2012: Genes & Development
J Patrick Lutz, Colin M Rathbun, Susan M Stevenson, Breanna M Powell, Timothy S Boman, Casey E Baxter, John M Zona, Jeffrey B Johnson
Rhodium-catalyzed intramolecular carboacylation of alkenes, achieved using quinolinyl ketones containing tethered alkenes, proceeds via the activation and functionalization of a carbon-carbon single bond. This transformation has been demonstrated using RhCl(PPh(3))(3) and [Rh(C(2)H(4))(2)Cl](2) catalysts. Mechanistic investigations of these systems, including determination of the rate law and kinetic isotope effects, were utilized to identify a change in mechanism with substrate. With each catalyst, the transformation occurs via rate-limiting carbon-carbon bond activation for species with minimal alkene substitution, but alkene insertion becomes rate-limiting for more sterically encumbered substrates...
January 11, 2012: Journal of the American Chemical Society
Rogier B Mars, Saad Jbabdi, Jérôme Sallet, Jill X O'Reilly, Paula L Croxson, Etienne Olivier, Maryann P Noonan, Caroline Bergmann, Anna S Mitchell, Mark G Baxter, Timothy E J Behrens, Heidi Johansen-Berg, Valentina Tomassini, Karla L Miller, Matthew F S Rushworth
Despite the prominence of parietal activity in human neuroimaging investigations of sensorimotor and cognitive processes, there remains uncertainty about basic aspects of parietal cortical anatomical organization. Descriptions of human parietal cortex draw heavily on anatomical schemes developed in other primate species, but the validity of such comparisons has been questioned by claims that there are fundamental differences between the parietal cortex in humans and other primates. A scheme is presented for parcellation of human lateral parietal cortex into component regions on the basis of anatomical connectivity and the functional interactions of the resulting clusters with other brain regions...
March 16, 2011: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Timothy W Felton, Caroline Baxter, Caroline B Moore, Stephen A Roberts, William W Hope, David W Denning
BACKGROUND: Chronic pulmonary aspergillosis (CPA) is a severe, progressive respiratory infection characterized by multiple pulmonary cavities and increased levels of antibodies to Aspergillus species. We report the first use of posaconazole in patients with CPA. METHODS: A retrospective study was performed. A composite clinical and radiological evaluation was used to assess response to posaconazole therapy. The rates of clinical response and failure after 6 and 12 months of therapy were determined...
December 15, 2010: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Wanfen Xiong, Jason MacTaggart, Rebecca Knispel, Jennifer Worth, Yuri Persidsky, B Timothy Baxter
Abdominal aortic aneurysm (AAA) is one of a number of diseases associated with a prominent inflammatory cell infiltrate and local destruction of structural matrix macromolecules. This chronic infiltrate is predominately composed of macrophages and T lymphocytes. Activated macrophages produce a variety of cytokines, including TNF-alpha. Elevated levels of TNF-alpha were observed in patients with AAA, suggesting that TNF-alpha may play a role in the pathogenic mechanisms of AAA. In the present study, we investigated the role of TNF-alpha in AAA formation...
August 15, 2009: Journal of Immunology: Official Journal of the American Association of Immunologists
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