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https://www.readbyqxmd.com/read/29659832/average-sperm-count-remains-unchanged-despite-reduction-in-maternal-smoking-results-from-a-large-cross-sectional-study-with-annual-investigations-over-21-years
#1
L Priskorn, L Nordkap, A K Bang, M Krause, S A Holmboe, D L Egeberg Palme, S B Winge, N Mørup, E Carlsen, U N Joensen, M Blomberg Jensen, K M Main, A Juul, N E Skakkebaek, T K Jensen, N Jørgensen
STUDY QUESTION: How are temporal trends in lifestyle factors, including exposure to maternal smoking in utero, associated to semen quality in young men from the general population? SUMMARY ANSWER: Exposure to maternal smoking was associated with lower sperm counts but no overall increase in sperm counts was observed during the study period despite a decrease in this exposure. WHAT IS KNOWN ALREADY: Meta-analyses suggest a continuous decline in semen quality but few studies have investigated temporal trends in unselected populations recruited and analysed with the same protocol over a long period and none have studied simultaneous trends in lifestyle factors...
April 11, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29615651/low-testosterone-in-apoe-ldl-receptor-double-knockout-mice-is-associated-with-rarefied-testicular-capillaries-together-with-fewer-and-smaller-leydig-cells
#2
Kai Steinfeld, Daniela Beyer, Christian Mühlfeld, Andrea Mietens, Gerrit Eichner, Bora Altinkilic, Marian Kampschulte, Qingkui Jiang, Gabriele A Krombach, Thomas Linn, Wolfgang Weidner, Ralf Middendorff
The testis as a site for atherosclerotic changes has so far attracted little attention. We used the apolipoprotein E (ApoE)/low density lipoprotein (LDL) receptor deficient mouse model (KO) for atherosclerosis (20, 40, 60 and 87-week-old) to investigate whether Leydig cells or the capillary network are responsible for reduced serum testosterone levels previously observed in extreme ages of this model. In KO mice, overall testosterone levels were reduced whereas the adrenal gland-specific corticosterone was increased excluding a general defect of steroid hormone production...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29615074/a-klinefelter-boy-with-congenital-adrenal-hyperplasia-too-much-or-too-little-androgens
#3
Giada Zanella, Gianluca Tornese, Elisabetta Mascheroni, Elena Faleschini, Alessandro Ventura, Egidio Barbi
BACKGROUND: The simultaneous occurrence of Klinefelter Syndrome (KS) and Congenital Adrenal Hyperplasia (CAH) is an exceptional event: there are just three case reports (two children and a 51 years old man) describing males affected by both KS and 21OHD (21-hydroxylase deficiency) CAH, the first causing androgen deficiency, the latter leading to androgen excess. CASE REPORT: We report the 4th case of association of KS and CAH in a young man with CAH with good androgen control and with normal secondary sex characteristics, whose Klinefelter syndrome was diagnosed because of reduced testicular volume...
April 3, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29605587/disparities-in-access-and-regionalization-of-care-in-testicular-cancer
#4
Liam C Macleod, Shannon S Cannon, Oliver Ko, George R Schade, Jonathan L Wright, Daniel W Lin, Sarah K Holt, John L Gore, Atreya Dash
INTRODUCTION: Timely mobilization of specialized resources are needed to achieve optimal outcomes in testicular cancer. We used the National Cancer Database to investigate the hospital and demographic features driving disparity. PATIENTS AND METHODS: We identified adult men with testicular tumors diagnosed from 2004 to 2013. We a priori examined the association among race/ethnicity, socioeconomic status (SES), travel burden, hospital characteristics, and indicators of delays in testicular cancer care...
February 23, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29605576/effects-of-maternal-dietary-selenium-se-enriched-yeast-on-testis-development-testosterone-level-and-testicular-steroidogenesis-related-gene-expression-of-their-male-kids-in-taihang-black-goats
#5
Lei Shi, Ruigao Song, Xiaolei Yao, Yunli Duan, Youshe Ren, Chunxiang Zhang, Wenbin Yue, Fulin Lei
To investigate the effects of maternal dietary selenium (Se-enriched yeast) on testis development, testosterone level and steroidogenesis-related gene expression in testis of their male kids, selected pregnant Taihang Black Goats were randomly allotted to four treatment groups. They were fed the basal gestation and lactation diets supplemented with 0 (control), 0.5, 2.0 and 4.0 mg of Se/kg DM. Thirty days after weaning, testes were collected from the kids. After the morphological development status of testis was examined, tissue samples were collected for analyzing testosterone concentration and histological parameters...
March 26, 2018: Theriogenology
https://www.readbyqxmd.com/read/29604178/cysteine-dioxygenase-is-essential-for-mouse-sperm-osmoadaptation-and-male-fertility
#6
Atsushi Asano, Heather B Roman, Lawrence L Hirschberger, Ai Ushiyama, Jacquelyn L Nelson, Meleana M Hinchman, Martha H Stipanuk, Alexander J Travis
Sperm entering the epididymis are immotile and cannot respond to stimuli that will enable them to fertilize. The epididymis is a highly complex organ, with multiple histological zones and cell types that together change the composition and functional abilities of sperm through poorly understood mechanisms. Sperm take up taurine during epididymal transit, which may play antioxidant or osmoregulatory roles. Cysteine dioxygenase (CDO) is a critical enzyme for taurine synthesis. A previous study reported that male CDO-/- mice exhibit idiopathic infertility, prompting us to investigate the functions of CDO in male fertility...
March 31, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29597124/plasma-igf-i-insl3-testosterone-inhibin-concentrations-and-scrotal-circumferences-surrounding-puberty-in-japanese-black-beef-bulls-with-normal-and-abnormal-semen
#7
W W P N Weerakoon, M Sakase, N Kawate, M A Hannan, N Kohama, H Tamada
The relationships between semen abnormalities and peripheral concentrations of testicular and metabolic hormones in beef bulls are unclear. Here we compared plasma insulin-like growth factor I (IGF-I), insulin-like peptide 3 (INSL3), testosterone, inhibin concentrations, and scrotal circumferences surrounding puberty in Japanese Black beef bulls (n = 66) with normal or abnormal semen. We collected blood samples and measured scrotal circumferences monthly from 4 to 24 months of age. Semen was collected weekly from 12 months until at least 18 months of age...
March 15, 2018: Theriogenology
https://www.readbyqxmd.com/read/29593790/association-between-dietary-patterns-and-precocious-puberty-in-children-a-population-based-study
#8
Chang Chen, Yao Chen, Yunting Zhang, Wanqi Sun, Yanrui Jiang, Yuanjin Song, Qi Zhu, Hao Mei, Xiumin Wang, Shijian Liu, Fan Jiang
Objective: The aim of the present study was to investigate the association between dietary patterns and precocious puberty among Shanghai children. Methods: A cross-sectional study was conducted among Shanghai children by multistage stratified cluster random sampling in June 2014. Diet was assessed using a simplified food frequency questionnaire (FFQ). Height, weight, and Tanner stages of breast development, pubic hair growth, and testicular volume were carefully measured...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29572055/prospective-evaluation-of-predictors-of-testis-atrophy-after-surgery-for-testis-torsion-in-children
#9
Gwen M Grimsby, Bruce J Schlomer, Vani S Menon, Lauren Ostrov, Melise Keays, Kunj R Sheth, Carlos Villanueva, Candace Granberg, Daniel Dajusta, Martinez Hill, Emma Sanchez, Clanton B Harrison, Micah A Jacobs, Berk Burgu, Halim Hennes, Linda A Baker
OBJECTIVE: To prospectively correlate pain duration, red scrotal skin, ultrasound appearance of testis, and intra-operative testis color to future testis atrophy after acute testicular torsion. METHODS: Consecutive children 2 months to18 years old with unilateral acute scrotum were enrolled in a NIH trans-cutaneous near infrared spectroscopy study, with a sub-group analysis of the true torsion group. Presence/absence of red scrotal skin, pain duration, testicular heterogeneity on pre-operative ultrasound, and intra-operative testis color based on a novel visual chart 5 minutes after detorsion were recorded...
March 20, 2018: Urology
https://www.readbyqxmd.com/read/29567201/in-utero-heat-stress-causes-reduced-testicular-area-at-puberty-reduced-total-sperm-production-and-increased-sperm-abnormalities-in-boars
#10
Drew W Lugar, Jarret A Proctor, Timothy J Safranski, Matthew C Lucy, Kara R Stewart
In utero stress has been shown to negatively affect intact male rats and mice, though very little research has been conducted in boars. The objectives of the present studies were to determine the effects of in utero heat stress (IUHS) on postnatal development and the response to postnatal heat stress of boars. Ten boars were selected at weaning from litters subjected to IUHS or in utero thermoneutral (IUTN) during 30-60 days of gestation. The boars were evaluated for reproductive performance from birth through 57 weeks of age (WOA)...
February 24, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29566548/the-role-of-arfi-elastography-to-evaluate-microstructrual-changes-of-patients-with-testicular-microlithiasis
#11
Serdar Aslan, Meltem Ceyhan Bilgici, Dilek Saglam, Mesut Ozturk
Background Testicular microlithiasis (TML) is thought to cause microstructural changes in the parenchyma of the testis, but it is difficult to demonstrate this by ultrasonography. It may be possible to evaluate microstructural changes in the testis by Acoustic Radiation Force Impulse (ARFI) elastography, which measures tissue stiffness. Purpose To assess the tissue stiffness of testicles of children with TML and to compare them with the healthy control group. Material and Methods Between November 2015 and May 2016, 25 pediatric patients with TML and 24 healthy children were enrolled in the study (mean age for TML and control group 6...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29530784/testis-sparing-surgery-for-benign-testicular-masses-diagnostics-and-therapeutic-approaches
#12
Pia Paffenholz, Linn Held, Sven H Loosen, David Pfister, Axel Heidenreich
PURPOSE: Small benign testicular masses are often misinterpreted as germ cell tumors, and immediate inguinal orchiectomy is performed. We aimed to analyse the diagnostic and therapeutic work-up of testicular masses in order to improve preoperative stratification algorithms. MATERIALS AND METHODS: We performed a retrospective, single-center analysis of 522 patients diagnosed with primary testicular masses of unknown malignant potential. RESULTS: 28 (5%) patients showed a primary benign tumor after resection: 9 (32%) Leydig cell tumors, 9 (32%) epidermoid cysts, 8 (29%) adenomatoid tumors and 2 (7%) Sertoli cell tumors...
March 9, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29528137/evaluation-of-seminal-plasma-proteomics-and-relevance-of-fsh-in-identification-of-nonobstructive-azoospermia-a-preliminary-study
#13
Z Cui, A Agarwal, B F da Silva, R Sharma, E Sabanegh
Nonobstructive azoospermia (NOA) patients present with high levels of serum FSH. At the protein level, the aetiology and pathways underlying different subtypes of NOA are unclear. The aim was to evaluate quantitatively differences in proteomic profiles of NOA patients presenting with normal serum FSH and normal testicular volume and high serum FSH and small testicular volume. The study comprised of 14 nonobstructive azoospermic men (N = 4; normal FSH and normal testicular volume and N = 10; high FSH and small testicular volume) and seven normozoospermic men...
March 12, 2018: Andrologia
https://www.readbyqxmd.com/read/29512726/ginsenoside-rg1-ameliorates-testicular-senescence-changes-in-d%C3%A2-gal%C3%A2-induced-aging-mice-via-anti%C3%A2-inflammatory-and-antioxidative-mechanisms
#14
Zi-Ling Wang, Lin-Bo Chen, Zhu Qiu, Xiong-Bin Chen, Ying Liu, Jing Li, Lu Wang, Ya-Ping Wang
With the growing population, aging, extended lifespans and anti-aging have become popular areas of research in the life and social sciences. With increasing age, the structure and function of the testes, the spermatogenetic and androgen‑producing organ in the male reproductive system, gradually declines. Ginsenoside Rg1 is an extract of Panax ginseng in traditional Chinese medicine. The extract facilitates anti‑aging through its anti‑inflammatory and antioxidant properties. However, it has not been reported whether ginsenoside Rg1 delays testicular aging...
March 1, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29512178/klinefelter-syndrome-and-fertility-impact-of-x-chromosomal-inheritance-on-spermatogenesis
#15
S Franik, D Smeets, G van de Zande, I Gomes, K D'Hauwers, D D M Braat, K Fleischer, L Ramos
With the use of testicular sperm extraction (TESE), spermatozoa can be retrieved in about 30%-50% of men with Klinefelter syndrome (KS). The reason for the absence or presence of spermatozoa in half of the men with KS remains unknown. Therefore, the search for an objective marker for a positive prediction in finding spermatozoa is of significant clinical value to avoid unnecessary testicular biopsies in males with (mostly) low testicular volume and impaired testosterone. The objective of this study was to determine whether paternal or maternal inheritance of the additional X-chromosome can predict the absence or presence of spermatogenesis in men with KS...
March 7, 2018: Andrologia
https://www.readbyqxmd.com/read/29511135/retroperitoneoscopic-varicocelectomy-in-adolescents-long-term-follow-up-in-two-italian-centres
#16
Molinaro Francesco, Cobellis Giovanni, Cerchia Elisa, Ferrara Francesco, Tallarico Rosella, Sica Marina, Noviello Carmine, Martino Ascanio, Angotti Rossella, Messina Mario
Background: The varicocele is the most commonly diagnosed pre-pubertal andrological condition with an incidence of 10%-15% between adolescents. The aim of this study was to evaluate the efficacy of retroperitoneoscopic varicocelectomy (RV) in two Italian centres with particular attention to post-operative testicular volume and semen analysis after 18 years of life. Materials and Methods: From 1999 to 2010, 286 adolescents underwent retroperitoneoscopic left varicocelectomy...
April 2017: African Journal of Paediatric Surgery: AJPS
https://www.readbyqxmd.com/read/29487620/retroperitoneal-lymph-node-dissection-as-primary-treatment-for-metastatic-seminoma
#17
REVIEW
Brian Hu, Siamak Daneshmand
Reducing the long-term morbidity in testicular cancer survivors represents a major area of interest. External beam radiation therapy and systemic chemotherapy are established treatments for seminoma; however, they are associated with late toxicities such as cardiovascular disease, insulin resistance, and secondary malignancy. Retroperitoneal lymph node dissection (RPLND) is a standard treatment for nonseminomatous germ cell tumors (NSGCT) that has minimal long-term morbidity. Given the efficacy of RPLND in management of NSGCT, interest has developed in this surgery as a front-line treatment for seminoma with isolated lymph node metastasis to the retroperitoneum...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29478823/characteristics-of-testicular-tumors-in-prepubertal-children-age-5-12-years
#18
Boaz Karmazyn, David L Weatherly, Stephen J Lehnert, Mark P Cain, Rong Fan, S Gregory Jennings, Fangqian Ouyang, Martin Kaefer
INTRODUCTION: Testicular tumors in children have two peaks with different types of tumors; in the first 4 years of life a third to half are benign with increased risk of malignancy during puberty. The pathology of testicular tumors between these peaks, at the age of 5-12 years, is not known. We hypothesized that because of the low level of testosterone at this time, the incidence of malignant tumors is very low. OBJECTIVE: To compare malignancy risk of primary testicular tumors in children in the prepubertal period (5-12 years) compared with younger (0-4 years) and pubertal (13-18 years) children...
February 13, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29477693/adolescent-varicocele-efficacy-of-indication-to-treat-protocol-and-proposal-of-a-grading-system-for-postoperative-hydroceles
#19
S Zundel, P Szavay, H-W Hacker, S Shavit
BACKGROUND: Varicocele is a common urologic anomaly in adolescent males; however, evidence-based treatment guidelines do not exist. Hydroceles are known to be a common complication after surgical therapy, with a wide variation in the reported incidence between 1 and 40%. AIM: This study aimed to introduce a standardized indication-to-treat protocol and prove its efficacy by analyzing the outcome of patients. Secondly, it aimed to better define postoperative hydroceles because the wide variation of reported incidence is attributed to a lack of definition...
February 8, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29461677/testicular-asymmetry-in-healthy-adolescent-boys
#20
Donald Vaganée, Frederik Daems, William Aerts, Rosina Dewaide, Tinne van den Keybus, Karen De Baets, Stefan De Wachter, Gunter De Win
OBJECTIVES: To assess the presence of testicular asymmetry and the currently used threshold values in varicocoele management in a healthy adolescent population. SUBJECTS AND METHODS: We conducted an observational cross-sectional study from April 2015 until December 2016 in which we recruited 539 adolescent boys aged 11-16 years. A clinical examination including testicular size measurement by ultrasonography was performed. Testicular volume (TV) was calculated using the Lambert formula (length × width × height × 0...
February 20, 2018: BJU International
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