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https://www.readbyqxmd.com/read/28338192/application-of-percutaneous-epididymal-sperm-aspiration-in-azoospermia
#1
L Hao, Z-G Li, H-G He, Z-G Zhang, J-J Zhang, Y Dong, Z-B Li, C-H Han
OBJECTIVE: The present study introduces the application of percutaneous epididymal sperm aspiration (PESA) for diagnosis of obstructive azoospermia and non-obstructive azoospermia. PATIENTS AND METHODS: 96 cases diagnosed with azoospermia were selected, standard methods were used to measure testicular volume, chemiluminescence was used to test serum sexual hormone levels, and No. 7 butterfly needles were applied to puncture the head of the epididymis and aspirate epididymal luminal fluid...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28304252/utility-of-orchidometric-parameters-for-assessing-sexual-maturation-in-male-cynomolgus-macaques-macaca-fascicularis
#2
Michael L Mirsky, Susan Portugal, Harshan Pisharath, Jodi L Osowski, Laura Kearney
Testicular volume is one of several parameters that have been used in preclinical toxicology to facilitate the identification of sexually mature male cynomolgus macaques when semen evaluation is unavailable. Furthermore, testicular volume provides additional information to pathologists to aid in the interpretation of microscopic findings. Orchidometry has been proposed as a useful tool for assessing testicular volume. To assess its utility for this purpose, we used orchidometry to measure testicular volume in untreated control male cynomolgus macaques during preclinical toxicology studies...
December 1, 2016: Comparative Medicine
https://www.readbyqxmd.com/read/28299523/predictors-for-spontaneous-pregnancy-after-microsurgical-subinguinal-varicocelectomy-a-prospective-cohort-study
#3
Jian-Wei Zhang, Quan-Quan Xu, You-Lin Kuang, Yan Wang, Feng Xu, Yu-Dong Tian
PURPOSE: The purpose of this study is to determine the possible preoperative predictors of spontaneous pregnancy (SPR) for infertile males with varicocele after microsurgical subinguinal varicocelectomy (MVL) performed in two medical centers in a prospective cohort study. METHODS: A total of 120 males with varicocele that underwent MVL between June 2013 and June 2014 in two medical centers were documented. Related data, including male and female partner age, male body mass index (BMI), female BMI, preoperative semen parameters, hormone levels, testicular volume, grade and side of varicocele, were collected and analyzed...
March 15, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28296054/modified-retroperitoneal-lymph-node-dissection-for-postchemotherapy-residual-tumor-a-long-term-update
#4
Jane S Cho, Hristos Z Kaimakliotis, K Clint Cary, Timothy A Masterson, Stephen Beck, Richard Foster
OBJECTIVES: To update previously reported outcomes of modified template postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) in appropriately selected patients with metastatic non-seminomatous germ cell tumor (NSGCT). Our previous report was criticized for short follow-up. Herein, we provide a long-term update on this cohort. MATERIALS AND METHODS: One hundred patients with normal serum markers after cisplatin-based chemotherapy and residual retroperitoneal tumor underwent modified PC-RPLND between 1991 and 2004...
March 13, 2017: BJU International
https://www.readbyqxmd.com/read/28295474/significant-predictive-factors-for-subfertility-in-patients-with-subclinical-varicocele
#5
S S-S Chen
We made a retrospective study to determine useful parameters for predicting subfertility in patients with subclinical varicocele (SV). One hundred and fifty men with SV and 17 age-matched men without SV were divided into three groups: Group 1, subfertile patients (n = 15); Group 2, fertile patients (n = 135); and Group 3, control patients (n = 17). Their age, body mass index (BMI), semen analysis, scrotal temperature, testicular volume, resistive index (RI), pulsatility index (PI) and peak retrograde flow (PRF) were compared...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28288913/germ-cell-neoplasia-in-situ-the-precursor-cell-for-invasive-germ-cell-tumors-of-the-testis
#6
Cassy M Spiller, Josephine Bowles
Germ cell neoplasia in situ is the non-invasive precursor cell of origin for type II testicular germ cell tumors. It has long been postulated that germ cell neoplasia in situ is derived from defective germ cell development during embryonic life, and although it is impossible to trace in vivo the progression from fetal germ cell to germ cell neoplasia in situ to tumor, there is a large volume of evidence supporting this theory. Current studies focus on understanding how germ cell neoplasia in situ forms, how these cells are activated at puberty and how they transform to invasive tumors of various subtypes...
March 10, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28281143/impact-of-the-fshb-gene-211g-t-polymorphism-on-male-gonadal-function
#7
L Tamburino, S La Vignera, V Tomaselli, R A Condorelli, L M Mongioì, A E Calogero
PURPOSE: The FSHB gene -211G/T polymorphism has been reported to modulate gene expression and to cause inter-individual differences in FSH serum levels in men. This study was undertaken to assess the functional relevance of this polymorphism on gonadotropin and total testosterone serum levels and sperm parameters in men from Eastern Sicily (Italy). METHODS: To accomplish this, 200 men with abnormal conventional sperm parameters or normozoospermia (according to the parameters of WHO 2010) were genotyped by TaqMan Assay...
March 9, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28270955/laparoscopic-one-stage-fowler-stephens-orchiopexy-preserving-gubernaculum
#8
Ali Naycı, Gökhan Berktuğ Bahadır, Cankat Erdoğan, Hakan Taşkınlar
OBJECTIVE: To assess gubernaculum-sparing laparoscopic one-stage Fowler-Stephens orchiopexy (FSO), in the management of high intrapelvic testis. MATERIAL AND METHODS: Medical reports of boys who underwent laparoscopic one-stage FSO were retrospectively reviewed. High intrapelvic testis was defined as testis ≥3 cm away from ipsilateral internal ring. Testes were evaluated on physical examination at 3(rd), 6(th) and 18(th) months after surgery. Children were evaluated as for their demographic data, operative findings, interventional details and outcomes...
March 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28270212/an-open-label-clinical-trial-to-investigate-the-efficacy-and-safety-of-corifollitropin-alfa-combined-with-hcg-in-adult-men-with-hypogonadotropic-hypogonadism
#9
Eberhard Nieschlag, Pierre-Marc G Bouloux, Barbara J Stegmann, R Ravi Shankar, Yanfen Guan, Anjela Tzontcheva, Christine McCrary Sisk, Hermann M Behre
BACKGROUND: Hypogonadotropic hypogonadism (HH) in men results in insufficient testicular function and deficiencies in testosterone and spermatogenesis. Combinations of human chorionic gonadotropin (hCG) and recombinant follicle-stimulating hormone (recFSH) have been successful in the treatment of HH. Corifollitropin alfa is a long-acting FSH-analog with demonstrated action in women seeking infertility care. The aim of this study was to investigate the efficacy and safety of corifollitropin alfa combined with hCG to increase testicular volume and induce spermatogenesis in men with HH...
March 7, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28258581/effects-of-anabolic-androgenic-steroids-on-the-reproductive-system-of-athletes-and-recreational-users-a-systematic-review-and-meta-analysis
#10
REVIEW
Maria A Christou, Panagiota A Christou, Georgios Markozannes, Agathocles Tsatsoulis, George Mastorakos, Stelios Tigas
BACKGROUND: Anabolic androgenic steroids (AAS) are testosterone derivatives used by athletes and recreational users to improve athletic performance and/or enhance appearance. Anabolic androgenic steroids use may have serious and potentially irreversible adverse effects on different organs and systems, including the reproductive system. OBJECTIVE: This systematic review and meta-analysis aimed to critically assess the impact of AAS use on the reproductive system of athletes and recreational users...
March 4, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28257149/pubertal-testis-volume-age-at-pubertal-onset-and-adolescent-blood-pressure-evidence-from-hong-kong-s-children-of-1997-birth-cohort
#11
Man Ki Kwok, Gabriel M Leung, C Mary Schooling
OBJECTIVES: A warning from Health Canada suggests that testosterone increases blood pressure (BP). No evidence from large randomized controlled trials is available, and observational studies are confounded by ill-health lowering serum testosterone. To address the evidence gap, we assessed the association of pubertal testicular volume, as a reflection of testosterone production, with BP. METHODS: We examined whether testicular volume was associated with sex-, age-, and height-standardized BP z-score at ∼13 years in a population-representative Chinese birth cohort (n = 5195, 63% follow-up)...
March 3, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28251288/rnai-as-a-tool-to-control-the-sex-ratio-of-mouse-offspring-by-interrupting-zfx-zfy-genes-in-the-testis
#12
YongSheng Zhang, JiFeng Xi, Bin Jia, XiangZu Wang, XuHai Wang, ChaoCheng Li, YaQiang Li, XianCun Zeng, RuiWen Ying, Xin Li, Song Jiang, FangYuan Yuan
The objective of this study was to explore a novel method to alter the sex-ratio balance of mouse offspring by silencing the paralogous genes Zfx/Zfy (Zinc finger X/Y-chromosomal transcription factor gene) during spermatogenesis. Four recombined vectors PRZ1, PRZ2, PRZ3, and PRZ4 (RNAi-Ready-pSIREN-RetroQ-ZsGreen) were constructed for interrupting the Zfx gene. Additionally, a recombined vector Psilencer/Zfy-shRNA was constructed for interrupting the Zfy gene. Male mice were randomly divided into 8 groups, with 20 animals per group...
March 1, 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/28250650/chronic-intake-of-green-propolis-negatively-affecting-the-rat-testis
#13
Grasiela Dias de Campos Severi-Aguiar, Suellen Josine Pinto, Cristina Capucho, Camila Andrea Oliveira, Maria Aparecida Diamante, Renata Barbieri, Fabrícia Souza Predes, Heidi Dolder
BACKGROUND: Human and animal evidence suggests that environmental toxicants may have an adverse impact on male reproductive health, reducing the population's reproductive output. Owing to the renewed attraction for natural products, some of them constitute effective alternatives to mitigate these effects. Propolis is a candidate for this use because of its intrinsic properties. In many situations, it improved the testicular damage and alleviated the toxic effects induced by environmental contaminant exposure...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28248755/testicular-growth-and-development-in-puberty
#14
Jaakko J Koskenniemi, Helena E Virtanen, Jorma Toppari
PURPOSE OF REVIEW: To describe pubertal testicular growth in humans, changes in testicular cell populations that result in testicular growth, and the role of testosterone and gonadotrophins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in testicular growth. When human data were not available, studies in nonhuman primates and/or rodents were used as surrogates. RECENT FINDINGS: Testicular growth in puberty follows a sigmoidal growth curve, with a large variation in timing of testicular growth and adult testicular volume...
February 28, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28237342/changes-of-plasma-concentrations-of-insulin-like-peptide-3-and-testosterone-and-their-association-with-scrotal-circumference-during-pubertal-development-in-male-goats
#15
M A Hannan, N Kawate, Y Fukami, W W P N Weerakoon, E E Büllesbach, T Inaba, H Tamada
Insulin-like peptide 3 (INSL3) has been used as a testis-specific biomarker for puberty in several species, but the secretory profile of INSL3 during pubertal development in small ruminants is unknown. Here we sought to determine the age-related changes in the plasma concentrations of INSL3 and testosterone and their association with scrotal circumference during pubertal development in five male Shiba goats. Blood samples and scrotal circumference measurement were taken every 2 weeks from week 10 to week 52 of each goat's lifespan...
April 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28231067/the-association-of-peripubertal-serum-concentrations-of-organochlorine-chemicals-and-blood-lead-with-growth-and-pubertal-development-in-a-longitudinal-cohort-of-boys-a-review-of-published-results-from-the-russian-children-s-study
#16
Oleg Sergeyev, Jane S Burns, Paige L Williams, Susan A Korrick, Mary M Lee, Boris Revich, Russ Hauser
Organochlorine chemicals and lead are environmental exposures that have endocrine disrupting properties (EDCs) which interfere with many aspects of hormone action. Childhood and adolescence are windows of susceptibility for adverse health effects of EDCs. Our ongoing study, the Russian Children's Study (RCS), is one of the few longitudinal studies investigating the impact of EDCs on growth and puberty in boys. It is conducted in the historically contaminated city of Chapaevsk, in the Samara region. The study focuses on evaluating the associations of persistent organochlorine chemicals and lead with growth and pubertal timing...
March 1, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28216922/a-prospective-randomized-comparative-trial-between-open-subinguinal-and-loupe-assisted-subinguinal-varicocelectome-a-single-center-experience
#17
Hari Gopal Vyas, Vimal Bhandari, Anup Kumar, Biswajit Nanda, Harbinder Singh, Subroto Bhowmick
INTRODUCTION: In our study, we reviewed efficacy and complication rates of open subinguinal varicocelectomy (OSV) and loupe assisted subinguinal varicocelectomy (LASV) using seminal and hormonal parameters in a prospective randomized study. MATERIALS AND METHODS: We prospectively studied 60 males with Grade 2 and Grade 3 varicocele. Thirty patients underwent OSV and the other 30 patients underwent LASV. Intra-operative and post-operative complications along with pre-operative and post-operative seminal, hormonal parameters and testicular volume were compared between the groups...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28190662/prospective-ultrasonographic-and-endocrine-predictors-of-spermatogenic-onset-in-ram-lambs
#18
Pawel M Bartlewski, Jennifer L Giffin, Olutobi A Oluwole, Ann C Hahnel
The objective of this study was to examine testicular ultrasonographic characteristics and endocrine profiles in prepubescent ram lambs for correlations with the age at first detection of elongated spermatids (ESt age). Bi-weekly ultrasound examinations and weekly testicular biopsies began at 10 weeks of age or at the time that testicular volume reached 15cm(3), and continued until 1-2 weeks after Est's were first detected by histological examination of testicular biopsies in twenty-two spring-born Rideau Arcott×Polled Dorset lambs...
April 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28181114/injury-to-the-male-external-genitalia-a-comprehensive-review
#19
REVIEW
James Furr, Daniel Culkin
While rare, trauma and injury to the male external genitalia can result in significant consequences regarding function, appearance, psychological effects, and overall quality of life. Due to the relative paucity of literature regarding male external genitalia injuries, few standardized protocols exist. This review aims to outline common clinical causes of male external genitalia injuries by both anatomic location and etiology. Initial stabilization, long-term reconstruction, and coverage options are discussed in detail...
April 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28153774/patterns-of-care-and-survival-outcomes-for-adolescent-and-young-adult-patients-with-testicular-seminoma-in-the-united-states-a-national-cancer-database-analysis
#20
William Stokes, Arya Amini, Paul D Maroni, Elizabeth R Kessler, Claire Stokes, Carrye R Cost, Brian S Greffe, Timothy P Garrington, Arthur K Liu, Nicholas G Cost
INTRODUCTION: Testicular germ cell tumors (GCTs) are the most common solid tumor among adolescent and young adult (AYA) males. AYA patients with GCTs most typically have non-seminoma compared with seminoma, and accordingly there are fewer data reported on the AYA experience with testicular seminoma. OBJECTIVE: To evaluate national trends in postoperative treatment and overall survival (OS) outcomes in testicular seminoma by age group, specifically comparing AYAs with older adults...
January 17, 2017: Journal of Pediatric Urology
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