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Cardiac arrthythmia

Derek P Chew, Matthew Horsfall, Andrew D McGavigan, Philip Tideman, Julian C Vaile, Catherine O'Shea, Belinda Moyes, Carmine De Pasquale
BACKGROUND: Ensuring optimal evidence translation is challenging when health-service design has not kept pace with developments in care. Differences in patient outcomes were evident when specific cardiac conditions were discordant with the subspecialty of the cardiologists managing their care. We prospectively explored the clinical and health service implications of a "condition-based" redesign in cardiac care delivery, rather than acuity-based, within a tertiary hospital. METHODS: Prospective evaluation of a disease-specific streaming model of care compared to propensity-matched historical controls, among cardiac patients admitted to a tertiary hospital cardiology unit was undertaken...
January 2016: Heart, Lung & Circulation
Marek Klocek, Agnieszka Skrzek, Danuta Czarnecka
The paper presents basic epidemiological, electrophysiological and therapeutical differences of cardiac arrhythmias depended on gender. Inadequate sinus tachycardia, orthostatic tachycardia syndrome and atrioventricular nodal reentrant tachycardia are more common in women as well as prolongation of QT interval and proarrhythmic phenomenon (especially torsade de pointes). Atrial fibrillation, although significantly less common in women, is more onerous, therapeutic aims are worse to achieve and outcomes are less favourable than in men...
2014: Przegla̧d Lekarski
Yong Cao, Lie Wang, Hong Chen, Zhiqian Lv
OBJECTIVE: A simple method to reduce the ischemia/reperfusion injury that can accompany cardiac surgery would have great clinical value. This study was to investigate the effect of hyperosmotic perfusion on ischemia/reperfusion injury in isolated perfused rat hearts. METHOD: Forty male Sprague-Dawley rats were randomly divided either to have their isolated hearts perfused with normal osmotic buffer or buffer made hyperosmotic by addition of glucose. Hearts were then subjected to 30 min ischemia followed by 30 min reperfusion...
March 2013: Revista Brasileira de Cirurgia Cardiovascular
S Runge, R Dietz, W Haverkamp
Atrial fibrillation is the most frequent cardiac arrthythmia in adults and its prevalence is increasing with age. Therefore, the importance of an adequate therapy is an increasing challenge, in particular considering the demographic shift towards an aging population. Current antiarrhythmic drug therapies for the conversion of atrial fibrillation and the maintenance of sinus rhythm are limited by efficacy, tolerance and safety of the currently available agents. Therefore, a primary goal is to develop effective antiarrhythmic drugs with as little as possible side effects...
December 2008: Deutsche Medizinische Wochenschrift
O Jurkovicová, S Cagán
Reperfusion arrhythmias originate as a consequence of the complex of cellular and humoral reactions accompanying the opening of coronary artery. As the primary cause of their generation are considered the chemically defined substances that are produced and accumulated in myocardium during reperfusion. The key role is ascribed to free oxygen radicals but of importance are also other substances such as calcium, thrombin, platelet activating factor, inositol triphosphate, angiotensin II and others. These chemical mediators of reperfusion arrhythmias operate as modulators of cellular electrophysiology causing the complex changes at the level of ion channels...
March 1998: Bratislavské Lekárske Listy
N S Moïse, M L Riccio, B Kornreich, W J Flahive, R F Gilmour
OBJECTIVES: The age-dependence of the development of ventricular arrhythmias was studied in German shepherd dogs with inherited ventricular arrhythmias and sudden death. BACKGROUND: A colony of German shepherd dogs has been established that exhibit inherited ventricular arrhythmias and sudden death. The incidence of arrhythmias increases with age. Because ventricular tachycardia is associated with bradycardia, it was hypothesized that the increased incidence of arrhythmias was related to age-dependent slowing of heart rate...
June 1997: Cardiovascular Research
V Kühlkamp, L Seipel
Bradyarrhythmias, depending on the patient population, are the cause of syncope in 3 to 10%. Marked bradycardia or asystole can be due to impaired function of the sinus node (sinus node syndrome) or high-grade AV-conduction block as well as carotid sinus syndrome and pathologic vasodepressor reactions. In particular, in the presence of high-grade AV-block, the diagnosis of bradyarrhythmia-induced syncope can frequently be established on the basis of a standard ECG. One of the most common causes of syncope is functional impairment of the sinus node, in particular, an inadequate permanent sinus bradycardia, sinus node arrest or SA-block and paroxysmal atrial tachycardia alternating with atrial bradycardia...
June 1993: Herz
S A Melikhov, A V Lirman, E A Filippov
Ten-minute-long resting electrocardiograms and functional tests (respiratory arrest, hyperventilation, orthostatic and exercise tests) under continuous cardiac rhythm monitoring were conducted in 239 young subjects between 10 and 35 years of age (153 skilled athletes, 62 apparently normal individuals and 24 young unskilled athletes). Arrthythmias were detected in 124 (51.9%) of those. Complex arrthythmias were particularly common in skilled athletes, as compared to normal subjects and young unskilled athletes (58...
November 1986: Kardiologiia
H L Greene
Prevention of sudden arrhythmic cardiac death must be preceded by identification of the high-risk patient to whom appropriate therapy can be given. The most common disease state associated with sudden cardiac death is coronary artery disease. Factors which identify a high-risk subset include: left ventricular dysfunction; frequent and complex arrhythmias on Holter monitoring; abnormal signal-averaged electrocardiograms; angina, ST depression, and exertional hypotension or ventricular arrthythmias on exercise testing; inducible sustained arrhythmias at electrophysiologic testing, or a combination of these factors...
March 1988: Clinical Cardiology
A P Matusova, V P Borin, V V Gladkov, A V Il'ichev, L A Mudrova
Patients with acute myocardial infarction and acute hemodynamic disorders were divided into 2 groups: 56 patients with severe arrthythmias (group 1) and 29 patients without heart rhythm disorders (group 2). Sinus rhythm analysis, making use of the computer technology and a specifically designed cardiac rhythm analyzer, RKAS-1, demonstrated changes, typical for patients at risk for severe arrhythmias. Segments of rigid rhythm alternating with those of high variability on the rhythmogram are a visual sign of electric instability of the heart...
March 1989: Kardiologiia
G J Taylor, R T Drew
The effects of inhaling fluorocarbon 12, a common propellant in household aerosols, were studied in closed-chested rabbits. Inhalation of 10 or 20% fluorocarbon 12 produced a decline in cardiac output and a dose-related depression of peak left ventricular (LV) dP/dt without associated arrthythmias, hypoxemia or significant changes in LV end-diastolicpressue or heart rate. There was a small decline in LV systolic pressure without a significant drop in mean arterial pressure. Breathing fluorocarbon 12 for 30 minutes caused a decline in peak LV dP/dt, cardiac output, LV systolic pressure and mean arterial pressure which was present throughout the exposure period...
January 1975: Journal of Pharmacology and Experimental Therapeutics
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