keyword
https://read.qxmd.com/read/37020342/atezolizumab-tecentriq-for-alveolar-soft-part-sarcoma
#21
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 3, 2023: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/36834580/a-comprehensive-review-of-risk-factors-for-venous-thromboembolism-from-epidemiology-to-pathophysiology
#22
REVIEW
Daniele Pastori, Vito Maria Cormaci, Silvia Marucci, Giovanni Franchino, Francesco Del Sole, Alessandro Capozza, Alessia Fallarino, Chiara Corso, Emanuele Valeriani, Danilo Menichelli, Pasquale Pignatelli
Venous thromboembolism (VTE) is the third most common cause of death worldwide. The incidence of VTE varies according to different countries, ranging from 1-2 per 1000 person-years in Western Countries, while it is lower in Eastern Countries (<1 per 1000 person-years). Many risk factors have been identified in patients developing VTE, but the relative contribution of each risk factor to thrombotic risk, as well as pathogenetic mechanisms, have not been fully described. Herewith, we provide a comprehensive review of the most common risk factors for VTE, including male sex, diabetes, obesity, smoking, Factor V Leiden, Prothrombin G20210A Gene Mutation, Plasminogen Activator Inhibitor-1, oral contraceptives and hormonal replacement, long-haul flight, residual venous thrombosis, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, trauma and fractures, pregnancy, immobilization, antiphospholipid syndrome, surgery and cancer...
February 5, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36786719/melanoma-during-pregnancy-as-a-complicated-medical-problem
#23
REVIEW
Klaudia Kościelecka, Daria Kubik-Machura, Aleksandra Kuć, Florentyna Furmanek, Tomasz Męcik-Kronenberg
IMPORTANCE: Pregnancy-associated melanomas (PAMs)-this is how melanomas identified during the childbearing years or up to 1 year after birth have been defined, accounting for one third of women in whom it is diagnosed. The exact epidemiology of melanoma is difficult to determine. However, its incidence is undoubtedly increasing, most likely related to the increasing age of mothers. OBJECTIVE: The purpose of this study was to review the prognosis, diagnosis, and treatment; the effect of melanoma on pregnancy; and the effect of pregnancy on melanoma and melanocytic lesions...
February 2023: Obstetrical & Gynecological Survey
https://read.qxmd.com/read/36720534/effectual-surgical-perineal-reconstruction-of-malignant-mucosal-vulvar-melanoma
#24
JOURNAL ARTICLE
Ying-Xuan Li, Wen-Chun Chang, Kuan-Ju Huang, Chin-Jui Wu, Lin-Hung Wei, Bor-Ching Sheu
OBJECTIVE: To demonstrate a successful surgical treatment and reconstruction in a case of malignant mucosal vulvar melanoma. CASE REPORT: A 52-year-old woman had stage II bulky malignant mucosal vulvar melanoma and received wide surgical excision with partial vulvectomy. She underwent 2-steps reconstructive vulvoplasty and vaginoplasty with skin grafting 1 year after initial surgical treatment. There was no evidence of recurrence after 3 years of follow-up. CONCLUSION: Vulvar melanoma is a rare malignant neoplasm...
January 2023: Taiwanese Journal of Obstetrics & Gynecology
https://read.qxmd.com/read/36719425/melanoma-in-pregnancy
#25
REVIEW
Ferenc Czeyda-Pommersheim, Harriet Kluger, Jonathan Langdon, Christine Menias, Wendaline VanBuren, Jonathan Leventhal, Raymond Baumann, Margarita Revzin
Melanoma is one of the most common types of cancer diagnosed during pregnancy. Patients with advanced disease require frequent staging examinations (e.g., CT, PET, MRI, ultrasound), which, during pregnancy must be modified from routine protocol to minimize risk to the fetus. We will review the diagnostic and treatment approach to pregnant patients with melanoma, with a discussion and pictorial examples of imaging protocol modifications, and the appearance of metastatic melanoma on radiology exams using modified protocols due to pregnancy...
May 2023: Abdominal Radiology
https://read.qxmd.com/read/36694327/management-of-brain-tumour-related-epilepsy-btre-a-narrative-review-and-therapy-recommendations
#26
REVIEW
Elizabeth Vacher, Miguel Rodriguez Ruiz, Jeremy H Rees
Brain Tumour Related Epilepsy (BTRE) has a significant impact on Quality of Life with implications for driving, employment, and social activities. Management of BTRE is complex due to the higher incidence of drug resistance and the potential for interaction between anti-cancer therapy and anti-seizure medications (ASMs). Neurologists, neurosurgeons, oncologists, palliative care physicians and clinical nurse specialists treating these patients would benefit from up-to-date clinical guidelines. We aim to review the current literature and to outline specific recommendations for the optimal treatment of BTRE, encompassing both Primary Brain Tumours (PBT) and Brain Metastases (BM)...
January 24, 2023: British Journal of Neurosurgery
https://read.qxmd.com/read/36683783/immunosuppressive-therapy-before-and-during-pregnancy-may-improve-obstetric-outcomes-in-pregnancy-complicated-by-dermatomyositis-with-anti-mda-5-antibody-positivity-a-case-report
#27
Hiroyuki Goto, Kimito Kawahata, Akiko Shida, Saeko Nakagane, Hitoshi Isohata, Yu Yamazaki, Yoshihiro Yoshimura, Kyoko Hattori, Kazuki Sekiguchi, Ryuzo Ishikawa, Yoko Onishi, Yuji Kanai, Nobuya Unno, Daigo Ochiai
Dermatomyositis (DM) is one of the most common autoimmune rheumatic diseases affecting women of childbearing age. Pregnancy may lead to exacerbation of DM, especially of DM with anti-melanoma differentiation-associated gene (MDA) 5 antibody positivity, leading to a poor obstetric outcome. Here, we report consecutive pregnancies complicated by DM with anti-MDA-5 antibodies. A 32-year-old pregnant woman, gravida 3 para 1, presented with fetal growth restriction. Emergency cesarean section was performed because of non-reassuring fetal status at 28 weeks of gestation...
March 2023: Case Reports in Women's Health
https://read.qxmd.com/read/36651796/opdualag-for-metastatic-melanoma
#28
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 23, 2023: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/36327112/successful-pregnancy-and-cancer-outcomes-with-ipilimumab-and-nivolumab-for-metastatic-renal-cell-carcinoma-case-report-and-review-of-the-literature
#29
JOURNAL ARTICLE
Francisco Zambrana, Carmen Barbancho, Miriam Huelves, Belén García de Santiago, Yolanda Martín, Marta Muñoz de Lengaria, Guillermo de Velasco
Pregnancy and cancer share CTLA-4 and PD-1/PD-L1 as some of the immunomodulatory pathways that reshape the immune system from a destructive response to a state of tolerance to the fetus and the tumor, respectively. Ipilimumab (anti-CTLA-4 inhibitor) and nivolumab (anti-PD-1 inhibitor) are used in combination for the treatment of metastatic renal cell carcinoma, and their use could theoretically result in an immune response against the fetus. Furthermore, these immune checkpoint inhibitors are immunoglobulin G antibodies that transfer from the mother to the fetus and may cause a direct toxicity...
November 4, 2022: Journal of Immunotherapy
https://read.qxmd.com/read/36299849/an-unusual-case-of-malignant-melanoma-with-metastasis-to-the-placenta-during-pregnancy
#30
JOURNAL ARTICLE
Kenny Garcia-Ramiu, Ibrahim Mohsin, Alexandra Ikeguchi, Brian Newberry
Introduction: We describe an unusual case of metastatic melanoma of the brain with an unknown primary site during pregnancy. Case Description: A 35-year-old woman in the third trimester of pregnancy presented with ataxia, nausea, vomiting, headaches and diplopia. CT of the brain revealed a hyper-attenuating 2.1 cm mass in the fourth ventricle with mild obstructive hydrocephalus. A healthy newborn was delivered by urgent caesarean section. Craniotomy and resection of the brain lesion confirmed melanoma...
2022: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/36291794/alcohol-as-a-non-uv-social-environmental-risk-factor-for-melanoma
#31
REVIEW
Takeshi Yamauchi, Sarah Shangraw, Zili Zhai, Dinoop Ravindran Menon, Nisha Batta, Robert P Dellavalle, Mayumi Fujita
Although cancer mortality has declined among the general population, the incidence of melanoma continues to rise. While identifying high-risk cohorts with genetic risk factors improves public health initiatives and clinical care management, recognizing modifiable risk factors such as social-environmental risk factors would also affect the methods of patient outreach and education. One major modifiable social-environmental risk factor associated with melanoma is ultraviolet (UV) radiation. However, not all forms of melanoma are correlated with sun exposure or occur in sun-exposed areas...
October 13, 2022: Cancers
https://read.qxmd.com/read/36174117/minding-the-bathwater-fertility-and-reproductive-toxicity-in-the-age-of-immuno-oncology
#32
REVIEW
Anne E Kim, Ariel Nelson, Kyle Stimpert, Rebecca L Flyckt, Nannan Thirumavalavan, Karen C Baker, Sophia C Weinmann, Christopher J Hoimes
Immune checkpoint inhibition has resulted in significant efficacy across many cancer types, including melanoma. Melanoma is the second most common cancer among those of reproductive age, yet the reproductive toxicities of adjuvant and first-line immunotherapy are largely unknown.The normal innate and adaptive immune systems play a vital role in reproductive organ homeostasis of men and women and are essential for implantation, fertility, and a successful pregnancy. The programmed cell death-1 receptor/programmed cell death receptor ligand-1 (PD-1/PD-L1) pathway is essential in several aspects of fertility and pregnancy...
December 2022: JCO oncology practice
https://read.qxmd.com/read/36094453/adrenal-metastatic-melanoma-first-identified-during-pregnancy-a-diagnostic-challenge
#33
JOURNAL ARTICLE
Tal Schiller, Edi Vaisbuch, Taiba Zornitzki, Alena Kirzhner
Adrenal nonadenomatous tumors (NAT) first identified during pregnancy are very rare and pose a diagnostic and therapeutic dilemma with significant risks for the mother and fetus. The aim of this study is to report a case of a large adrenal NAT identified in pregnancy and literature review. A literature search was conducted, and data were summarized. A 37-year-old primigravida woman, with a history of melanoma, excised 12 years before presentation without recurrence, presented at 35 weeks gestation due to intractable right flank pain...
September 13, 2022: Melanoma Research
https://read.qxmd.com/read/35870141/melanoma-in-women-of-childbearing-age-and-in-pregnancy-in-california-1994-2015-a-population-based-cohort-study
#34
JOURNAL ARTICLE
M Kiuru, Q Li, G Zhu, J R Terrell, K Beroukhim, E Maverakis, T H M Keegan
BACKGROUND: Melanoma is one of the most common malignancies during pregnancy. There is debate regarding the impact of pregnancy on the prognosis of melanoma. Recent large population-based studies from the United States are lacking. OBJECTIVES: To determine the characteristics and survival of women with pregnancy-associated melanoma. METHODS: This population-based, retrospective cohort study used California Cancer Registry data linked with state-wide hospitalization and ambulatory surgery data to identify 15-44-year-old female patients diagnosed with melanoma in 1994-2015, including pregnant patients...
November 2022: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/35855660/fertility-preservation-for-patients-with-melanoma
#35
JOURNAL ARTICLE
Francesca Filippi, Nicole Serra, Paola Vigano, Luca Boeri, Carolina Cimminiello, Lorenza Di Guardo, Edgardo Somigliana, Michele Del Vecchio
The advent of immunotherapy and targeted therapy has outstandingly improved the prognosis in subjects with melanoma. Their use is now advocated also in earlier stages as an adjuvant therapy, and some neoadjuvant clinical trials are ongoing. Consequently, survivors free of disease are increasing, as well as those exposed to these new agents. Parenthood in survivors is, therefore, receiving growing interest. Evidence on the effects of immunotherapy and targeted therapy on future fertility is limited, but not entirely reassuring, in particular for immunotherapy...
July 19, 2022: Melanoma Research
https://read.qxmd.com/read/35801889/-the-effect-of-sex-hormones-and-pregnancy-on-development-and-progression-of-uveal-melanoma
#36
JOURNAL ARTICLE
V G Likhvantseva, V E Ovanesyan
The analysis of literature revealed that men experience uveal melanoma (UM) more frequently and with worse prognosis. There are also descriptions of an aggressive course of UM in pregnant women. These facts prompted researchers to analyze the effect of sex hormones and pregnancy on the development and progression of UM. Many years of international experience have refuted the presence of a reliable difference between 5-year survival and 5-year survival without metastases between non-pregnant women with UM and pregnant women with UM...
2022: Vestnik Oftalmologii
https://read.qxmd.com/read/35696885/ten-year-experience-of-a-national-multidisciplinary-tumour-board-for-cancer-and-pregnancy-in-the-netherlands
#37
JOURNAL ARTICLE
Joosje H Heimovaara, Ingrid A Boere, Jorine de Haan, Kristel van Calsteren, Frédéric Amant, Lia van Zuylen, Christine A R Lok
BACKGROUND: Most physicians encounter pregnant women with cancer incidentally, leading to a lack of expertise or confidence to inform and treat these patients based on the most recent guidelines and expert opinions. In the Netherlands, a national multidisciplinary tumour board for cancer, infertility and pregnancy (CIP-MDT) was founded in December 2012, including 35 specialists from a variety of disciplines. This study evaluates the frequency of consultation of the CIP-MDT, the types of questions asked and the satisfaction of consulting physicians with its existence...
August 2022: European Journal of Cancer
https://read.qxmd.com/read/35372436/sexual-dimorphisms-of-protein-coding-gene-profiles-in-placentas-from-women-with-systemic-lupus-erythematosus
#38
JOURNAL ARTICLE
Hui-Hui Li, Lin-Tao Sai, Shan Tian, Yuan Liu, Colman I Freel, Kai Wang, Chi Zhou, Jing Zheng, Qiang Shu, Ying-Jie Zhao
Background: Systemic lupus erythematosus (SLE) may cause pathogenic changes in the placentas during human pregnancy, such as decreased placental weight, intraplacental hematoma, ischemic hypoxic change, placental infarction, and decidual vasculopathy, which contribute to high maternal and fetal mortality and morbidity. Sex-specific adaptations of the fetus are associated with SLE pregnancies. The present study aimed to determine the transcriptomic profiles of female and male placentas from women with SLE...
2022: Frontiers in Medicine
https://read.qxmd.com/read/35325701/melanoma-in-pregnancy-diagnosis-and-management-in-early-stage-and-advanced-disease
#39
REVIEW
Thomas J Carter, Christina George, Catherine Harwood, Paul Nathan
Approximately one-third of women diagnosed with melanoma are of child-bearing age. The annual incidence of melanoma has risen steadily over the last 40 years, resulting in increasing numbers of women diagnosed with melanoma both during pregnancy, and post-partum. To date, there are no formal guidelines on the management of pregnancy associated melanoma (PAM), both early stage and metastatic. This article reviews the existing literature and provides a framework for the investigation and multidisciplinary management of PAM...
May 2022: European Journal of Cancer
https://read.qxmd.com/read/35011822/survival-of-women-previously-diagnosed-of-melanoma-with-subsequent-pregnancy-a-systematic-review-and-meta-analysis-and-a-single-center-experience
#40
REVIEW
Nieves Martínez-Campayo, Sabela Paradela de la Morena, Sonia Pértega-Díaz, Luisa Iglesias Pena, Pia Vihinen, Kalle Mattila, Marko B Lens, Antonio Tejera-Vaquerizo, Eduardo Fonseca
Melanoma incidence has increased over the last few decades. How the prognosis of a previously diagnosed melanoma may be affected by a woman's subsequent pregnancy has been debated in the literature since the 1950s, and the outcomes are essential to women who are melanoma survivors in their childbearing years. The main objective of this systematic review is to improve the understanding of whether the course of melanoma in a woman may be altered by a subsequent pregnancy and to help clinicians' diagnosis. Eligible studies for the systematic review were clinical trials, observational cohort studies and case-control studies that compared prognosis outcomes for non-pregnant patients with melanoma, or pregnant before melanoma diagnosis, versus pregnant patients after a diagnosis of melanoma...
December 24, 2021: Journal of Clinical Medicine
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