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melanoma and pregnancy

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https://www.readbyqxmd.com/read/29132694/unrelated-immunodeficiency-states-may-impact-outcomes-and-immune-checkpoint-molecule-expression-in-patients-with-mycosis-fungoides-a-clinicopathologic-case-control-study
#1
Shay Warren, Meenal Kheterpal, Patricia L Myskowski, Alison Moskowitz, Steven M Horwitz, Melissa P Pulitzer
BACKGROUND: Immunodeficiency (ID) correlates with worse outcomes and decreased immune checkpoint molecule expression in melanoma. The impact of ID in mycosis fungoides (MF) is unknown. OBJECTIVE: Our goal was to evaluate the impact of ID in MF. METHODS: We conducted a case-control study of 17 patients with MF and ID versus age-, stage-, and race-matched controls as a subset of a comparative analysis of 23 patients with MF with ID (prior lymphoma, recent/current pregnancy, HIV, hypogammaglobulinemia, and prior chemotherapy) versus without ID...
November 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29051777/melanoma-in-pregnancy
#2
REVIEW
Rebecca Still, Shaun Brennecke
Melanoma is one of the most common cancers diagnosed in pregnancy and has a high metastatic potential. As the incidence of melanoma increases, careful clinical evaluation of suspicious skin lesions remains the mainstay of early diagnosis. There is controversy in the literature as to whether pregnancy-associated melanoma has worse survival than other melanomas. Any changing-pigmented lesion should be biopsied, regardless of pregnancy hyperpigmentation. Increased lymphangiogenesis in pregnancy is associated with increased metastasis - timely diagnosis is therefore imperative...
September 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/28880927/scf-kit-signaling-induces-endothelin-3-synthesis-and-secretion-thereby-activates-and-regulates-endothelin-b-receptor-for-generating-temporally-and-spatially-precise-nitric-oxide-to-modulate-scf-and-or-kit-expressing-cell-functions
#3
Lei L Chen, Jing Zhu, Jonathan Schumacher, Chongjuan Wei, Latha Ramdas, Victor G Prieto, Arnie Jimenez, Marco A Velasco, Sheryl R Tripp, Robert H I Andtbacka, Launce Gouw, George M Rodgers, Liansheng Zhang, Benjamin K Chan, Pamela B Cassidy, Robert S Benjamin, Sancy A Leachman, Marsha L Frazier
We demonstrate that SCF-KIT signaling induces synthesis and secretion of endothelin-3 (ET3) in human umbilical vein endothelial cells and melanoma cells in vitro, gastrointestinal stromal tumors, human sun-exposed skin, and myenteric plexus of human colon post-fasting in vivo. This is the first report of a physiological mechanism of ET3 induction. Integrating our finding with supporting data from literature leads us to discover a previously unreported pathway of nitric oxide (NO) generation derived from physiological endothelial NO synthase (eNOS) or neuronal NOS (nNOS) activation (referred to as the KIT-ET3-NO pathway)...
2017: PloS One
https://www.readbyqxmd.com/read/28868278/conjunctival-melanoma-during-pregnancy
#4
Rana'a T Al-Jamal, Hardeep Singh Mudhar, Zanna Currie, Ian G Rennie, Sachin M Salvi
PURPOSE: To describe the clinical and histopathological features of a conjunctival melanoma (CM) during early pregnancy. PROCEDURES: A 37-year-old, 20-week pregnant primigravida was referred to the Sheffield Ocular Oncology Service with a rapidly growing lesion arising from the right superior conjunctival fornix, noted from the first trimester of pregnancy. This was associated with pain and bloody discharge. Incisional biopsy confirmed the clinical suspicion of invasive CM...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28836277/the-risk-of-preterm-birth-and-growth-restriction-in-pregnancy-after-cancer
#5
Kathleen P Hartnett, Kevin C Ward, Michael R Kramer, Timothy L Lash, Ann C Mertens, Jessica B Spencer, Amy Fothergill, Penelope P Howards
It is unclear whether cancer and its treatments increase the risk of adverse pregnancy outcomes. Our aim was to examine whether cancer survivors have higher risks of poor outcomes in pregnancies conceived after diagnosis than women without cancer, and whether these risks differ by cancer type and race. Diagnoses from cancer registries were linked to pregnancy outcomes from birth certificates in three U.S. states. Analyses were limited to the first, live singleton birth conceived after diagnosis. Births to women without a previous cancer diagnosis in the registry were matched to cancer survivors on age at delivery, parity, race/ethnicity and education...
December 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28598867/pathophysiology-of-antenatal-bartter-s-syndrome
#6
Martin Kömhoff, Kamel Laghmani
PURPOSE OF REVIEW: Antenatal Bartter syndrome (aBS) is a heterogenous disease resulting from defective ion transport in the thick ascending limb of the loop of Henle. Novel insights into the pathophysiology, as well as the recent identification of a novel genetic cause of aBS, merit an update on this topic. RECENT FINDINGS: In aBS, severe salt losing is further aggravated by defective salt sensing in the macula densa, where a reduced tubular salt concentration is perceived and glomerular filtration is increased instead of decreased...
September 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28527349/maternal-and-perinatal-outcomes-in-pregnancy-associated-melanoma-report-of-two-cases-and-a-systematic-literature-review
#7
Elsa Mendizábal, Juan De León-Luis, Natalia R Gómez-Hidalgo, Laura Joigneau, Pilar Pintado, Patricia Rincón, Virginia Ortega, Santiago Lizarraga
OBJETIVES: Melanoma is one of the most frequent malignancies during gestation. However, oncological and perinatal management is still challenging. Our first objective is to describe the cases of pregnancy-associated melanoma (PAM) diagnosed in our centre between January-2004 and May-2015. Secondly, to perform a systematic review of the published articles analysing the maternal-perinatal outcomes of patients diagnosed with PAM. DESIGN, POPULATION AND METHODS: Obstetrical, oncological and perinatal variables were recorded in the case series...
July 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28524047/oestrogen-and-progesterone-receptors-in-melanoma-and-nevi-an-immunohistochemical-study
#8
Emi Dika, Pier Alessandro Fanti, Sabina Vaccari, Elisa Capizzi, Alessio Degiovanni, Agnese Gobbi, Bianca Maria Piraccini, Simone Ribero, Carlotta Baraldi, Giulia Maria Ravaioli, Michelangelo Fiorentino, Annalisa Patrizi
The effect of hormonal stimulation and fertility treatments, on the development of malignant melanoma (MM) remains to be determined. The aim of this study was to investigate the presence of oestrogen receptor alpha (ERα) and progesterone receptor (PR) in MM and nevi after hormonal stimulation. Immunohistochemical analyses were performed utilizing antibodies specifically directed against ERα and PR in MM and atypical nevi specimens from patients: (1) diagnosed during pregnancy, (2) diagnosed in the six months following delivery, or (3) who had undergone repetitive cycles of hormonal stimulation for in vitro fertilization (IVF) in the year that preceded MM diagnosis...
June 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28492051/prognosis-for-women-diagnosed-with-melanoma-during-before-or-after-pregnancy-weighing-the-evidence
#9
REVIEW
Sarah P Todd, Marcia S Driscoll
Approximately one third of women who are diagnosed with malignant melanoma are of childbearing age. Therefore, it is not surprising that some studies have found malignant melanoma to be one of the most common malignancies diagnosed in pregnant women. The impact of pregnancy-related hormonal changes on melanoma development and progression remains controversial. Women undergo immunologic changes during pregnancy that may decrease tumor surveillance. Additionally, hormone receptors are found on some melanomas...
March 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28492033/cutaneous-melanoma-in-women
#10
REVIEW
Mi Ryung Roh, Philip Eliades, Sameer Gupta, Jane M Grant-Kels, Hensin Tsao
BACKGROUND: Gender disparity in melanoma outcome is consistently observed, suggesting that gender is as an important prognostic factor. However, the source of this gender disparity in melanoma remains unclear. OBJECTIVE: This article reviews advances in our understanding of gender differences in melanoma and how such differences may contribute to outcomes. METHODS: A broad literature search was conducted using the PubMed database, with search terms such as 'gender differences in melanoma' and 'sex differences in melanoma...
March 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28468571/melanoma-and-pregnancy-a-case-report
#11
Roberto Anaya-Prado, Elodia Noemi Ruvalcaba-Soto, Michelle Marie Anaya-Fernández, Juan Antonio Delgado-Vazquez, Francisco Gil-Villarreal, Miguel A Guerrero-Palomera, Shamandra Marquí Aguilar-Córdova, Francisco Godinez-Plascencia
No abstract text is available yet for this article.
May 4, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28467693/expression-of-g-protein-coupled-oestrogen-receptor-in-melanoma-and-in-pregnancy-associated-melanoma
#12
M Fábián, F Rencz, T Krenács, V Brodszky, J Hársing, K Németh, P Balogh, S Kárpáti
BACKGROUND: The hormone sensitivity of melanoma and the role of 'classical' oestrogen receptor (ER) α and β in tumour progression have been intensively studied with rather contradictory results. The presence of 'non-classical' G protein-coupled oestrogen receptor (GPER) has not been investigated on human melanoma tissues. OBJECTIVE: To analyse the expression of GPER, ERα and ERβ in pregnancy-associated (PAM) and in non-pregnancy-associated (NPAM) melanomas in correlation with traditional prognostic markers and disease-free survival (DFS)...
May 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28457692/is-pregnancy-associated-melanoma-associated-with-adverse-outcomes
#13
Maris S Jones, Jihey Lee, Stacey L Stern, Mark B Faries
BACKGROUND: Melanoma is the most common malignancy encountered during pregnancy. Conflicting data have led to ongoing confusion regarding pregnancy-associated melanoma (PAM) in the media and among the public. The objective of this study was to better characterize both the clinical presentation of PAM and its prognostic implications. STUDY DESIGN: Female patients of reproductive age, with stage 0 to IV cutaneous melanoma, were identified from our prospectively maintained database...
July 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28430756/does-pregnancy-influence-melanoma-prognosis-a-meta-analysis
#14
Athanassios Kyrgidis, Aimilios Lallas, Elvira Moscarella, Caterina Longo, Roberto Alfano, Giuseppe Argenziano
The literature has not been able to conclude whether pregnancy influences the prognosis of melanoma. The aim of this study was to explore the prognosis of melanoma diagnosed during pregnancy or post partum [pregnancy-associated melanoma (PAM)] compared with melanoma in female patients who were not pregnant. We systematically searched for studies of female patients with melanoma that reported outcomes related to survival. Fifteen eligible studies were found. Overall, PAM was associated with a 17% higher mortality compared with melanoma diagnosed in female patients who were not pregnant (hazard ratio=1...
August 2017: Melanoma Research
https://www.readbyqxmd.com/read/28185271/melanoma-and-pregnancy
#15
REVIEW
Sarah Kym Morton, Adam Park Morton
Melanoma is the most common cancer in women during their reproductive years and kills more young Australians than any other single cancer. Care of women whose pregnancy is complicated by a diagnosis of malignancy is complex. The risk of delaying treatment to the mother, the short-term and long-term risks of premature delivery to the child, and the immediate risks to the foetus and long-term risks to the child of maternal treatment with surgery, radiotherapy or medical therapies must be considered.
February 10, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28121082/melanoma-and-pregnancy
#16
REVIEW
Camilla Salvini, Federica Scarfì, Caterina Fabroni, Franca Taviti
The last decades were characterized by a worldwide increasing incidence in melanoma. Almost 35% of diagnosed with melanoma women are in childbearing age. Malignant melanoma is the most common malignancy during pregnancy. Considering this background it is clear how melanoma and pregnancy has becoming one of the main topic of discussion. Current knowledge about pregnancy and melanoma is characterized by many controversies and divergences. The real incidence of melanoma in childbearing and the impact of pregnancy on the prognosis of melanoma is still unclear...
June 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28107260/frequency-of-pregnancy-related-cancer-a-population-based-linkage-study-in-lombardy-italy
#17
Fabio Parazzini, Matteo Franchi, Alessandra Tavani, Eva Negri, Fedro Alessandro Peccatori
OBJECTIVES: The aims of this study were to estimate the occurrence of pregnancy-associated cancer overall and by site, to evaluate if the risk increases over time, and to investigate some major determinants. METHODS: This is a population-based linkage study using the regional hospital discharge forms [Scheda di Dimissione Ospedaliera (SDO)] database of Lombardy, Italy, a region with 10 million inhabitants. All resident women with a SDO reporting a birth or abortion between 2001 and 2012 were identified...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28099365/melanoma-during-pregnancy-a-report-of-60-pregnancies-complicated-by-melanoma
#18
Jorine de Haan, Christianne A Lok, Christianne J de Groot, Marianne B Crijns, Kristel Van Calsteren, Karina Dahl Steffensen, Michael J Halaska, Sevilay Altintas, Ingrid A Boere, Robert Fruscio, Wojciech Kolawa, Petronella O Witteveen, Frédéric Amant
The management of melanoma during pregnancy is challenging as maternal benefits and fetal risks need to be balanced. Here, we present an overview of the incidence, the demographic and clinical characteristics and the treatment modalities used. After analysis of obstetric, fetal and maternal outcome, recommendations for clinical practice are provided. From the 'International Network on Cancer, Infertility and Pregnancy' database, pregnant patients with melanoma were identified and analysed. Sixty pregnancies were eligible for analysis...
June 2017: Melanoma Research
https://www.readbyqxmd.com/read/28058467/-treatment-of-melanoma-during-pregnancy
#19
REVIEW
L A Schneider
Melanoma diagnosed during pregnancy is a rare clinical case presentation which must be mastered. In the absence of guidelines for this clinical challenge, we performed a review of the literature and provide a practical guideline on how to manage such rare clinical cases based on our clinical experience. Expecting mothers require adequate counselling and explanation of all therapeutic options as they take responsibility for more than their own lives. However, they should be guided through the process of diagnostic and therapeutic measures in a potentially life-threatening situation...
February 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28003813/context-specific-and-immune-cell-dependent-antitumor-activities-of-%C3%AE-1-antitrypsin
#20
Ofer Guttman, Gabriella S Freixo-Lima, Ziv Kaner, Yotam Lior, Peleg Rider, Eli C Lewis
α1-antitrypsin (AAT), a circulating glycoprotein that rises during acute phase responses and healthy pregnancies, exhibits immunomodulatory properties in several T-cell-dependent immune pathologies. However, AAT does not directly interfere with T-cell responses; instead, it facilitates polarization of macrophages and dendritic cells towards M2-like and tolerogenic cells, respectively. AAT also allows NK cell responses against tumor cells, while attenuating DC-dependent induction of autoimmune NK cell activities...
2016: Frontiers in Immunology
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