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melanoma and pregnancy

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https://www.readbyqxmd.com/read/28527349/maternal-and-perinatal-outcomes-in-pregnancy-associated-melanoma-report-of-two-cases-and-a-systematic-literature-review
#1
Elsa Mendizábal, Juan De León-Luis, Natalia R Gómez-Hidalgo, Laura Joigneau, Pilar Pintado, Patricia Rincón, Virginia Ortega, Santiago Lizarraga
OBJETIVES: Melanoma is one of the most frequent malignancies during gestation. However, oncological and perinatal management is still challenging. Our first objective is to describe the cases of pregnancy-associated melanoma (PAM) diagnosed in our centre between January-2004 and May-2015. Secondly, to perform a systematic review of the published articles analysing the maternal-perinatal outcomes of patients diagnosed with PAM. DESIGN, POPULATION AND METHODS: Obstetrical, oncological and perinatal variables were recorded in the case series...
April 21, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28524047/oestrogen-and-progesterone-receptor-in-melanoma-and-nevi-an-immunohistochemical-study
#2
Emi Dika, Pier Alessandro Fanti, Sabina Vaccari, Elisa Capizzi, Alessio Degiovanni, Agnese Gobbi, Bianca Maria Piraccini, Simone Ribero, Carlotta Baraldi, Giulia Maria Ravaioli, Michelangelo Fiorentino, Annalisa Patrizi
The effect of hormonal stimulation and fertility treatments, as well as their role in the development of malignant melanoma (MM), is still to be determined. The aim of this study was to investigate the presence of oestrogen receptor alpha (ERα) and progesterone receptor (PR) in MM and nevi after hormonal stimulation. Immunohistochemical analyses were performed utilizing antibodies specifically directed against ERα and PR in MM and atypical nevi specimens from patients: (1) diagnosed during pregnancy, (2) diagnosed in the six months following delivery, or (3) who had undergone repetitive cycles of hormonal stimulation for in vitro fertilization in the year that preceded MM diagnosis...
May 19, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28492051/prognosis-for-women-diagnosed-with-melanoma-during-before-or-after-pregnancy-weighing-the-evidence
#3
REVIEW
Sarah P Todd, Marcia S Driscoll
Approximately one third of women who are diagnosed with malignant melanoma are of childbearing age. Therefore, it is not surprising that some studies have found malignant melanoma to be one of the most common malignancies diagnosed in pregnant women. The impact of pregnancy-related hormonal changes on melanoma development and progression remains controversial. Women undergo immunologic changes during pregnancy that may decrease tumor surveillance. Additionally, hormone receptors are found on some melanomas...
March 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28492033/cutaneous-melanoma-in-women
#4
REVIEW
Mi Ryung Roh, Philip Eliades, Sameer Gupta, Jane M Grant-Kels, Hensin Tsao
BACKGROUND: Gender disparity in melanoma outcome is consistently observed, suggesting that gender is as an important prognostic factor. However, the source of this gender disparity in melanoma remains unclear. OBJECTIVE: This article reviews advances in our understanding of gender differences in melanoma and how such differences may contribute to outcomes. METHODS: A broad literature search was conducted using the PubMed database, with search terms such as 'gender differences in melanoma' and 'sex differences in melanoma...
March 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28468571/melanoma-and-pregnancy-a-case-report
#5
Roberto Anaya-Prado, Elodia Noemi Ruvalcaba-Soto, Michelle Marie Anaya-Fernández, Juan Antonio Delgado-Vazquez, Francisco Gil-Villarreal, Miguel A Guerrero-Palomera, Shamandra Marquí Aguilar-Córdova, Francisco Godinez-Plascencia
No abstract text is available yet for this article.
May 4, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28467693/expression-of-g-protein-coupled-estrogen-receptor-gper-in-melanoma-and-in-pregnancy-associated-melanoma
#6
M Fábián, F Rencz, T Krenács, V Brodszky, J Hársing, K Németh, P Balogh, S Kárpáti
BACKGROUND: The hormone sensitivity of melanoma and the role of 'classical' estrogen receptor (ER) α and β in tumor progression have been intensively studied with rather contradictory results. The presence of 'non-classical' G protein-coupled estrogen receptor (GPER) has not been investigated on human melanoma tissues. OBJECTIVE: To analyze the expression of GPER, ERα and ERβ in pregnancy-associated (PAM) and in non-pregnancy associated (NPAM) melanomas in correlation with traditional prognostic markers and disease-free survival (DFS)...
May 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28457692/is-pregnancy-associated-melanoma-associated-with-adverse-outcomes
#7
Maris S Jones, Jihey Lee, Stacey L Stern, Mark B Faries
BACKGROUND: Melanoma is the most common malignancy encountered during pregnancy. Conflicting data have led to ongoing confusion regarding pregnancy-associated melanoma (PAM) in the media and among the public. The objective of this study was to better characterize both the clinical presentation of PAM and its prognostic implications. STUDY DESIGN: Female patients of reproductive age, with stage 0 to IV cutaneous melanoma, were identified from our prospectively maintained database...
March 23, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28430756/does-pregnancy-influence-melanoma-prognosis-a-meta-analysis
#8
Athanassios Kyrgidis, Aimilios Lallas, Elvira Moscarella, Caterina Longo, Roberto Alfano, Giuseppe Argenziano
The literature has not been able to conclude whether pregnancy influences the prognosis of melanoma. The aim of this study was to explore the prognosis of melanoma diagnosed during pregnancy or post partum [pregnancy-associated melanoma (PAM)] compared with melanoma in female patients who were not pregnant. We systematically searched for studies of female patients with melanoma that reported outcomes related to survival. Fifteen eligible studies were found. Overall, PAM was associated with a 17% higher mortality compared with melanoma diagnosed in female patients who were not pregnant (hazard ratio=1...
April 20, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28185271/melanoma-and-pregnancy
#9
REVIEW
Sarah Kym Morton, Adam Park Morton
Melanoma is the most common cancer in women during their reproductive years and kills more young Australians than any other single cancer. Care of women whose pregnancy is complicated by a diagnosis of malignancy is complex. The risk of delaying treatment to the mother, the short-term and long-term risks of premature delivery to the child, and the immediate risks to the foetus and long-term risks to the child of maternal treatment with surgery, radiotherapy or medical therapies must be considered.
February 10, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28121082/melanoma-and-pregnancy
#10
Camilla Salvini, Federica Scarfì, Caterina Fabroni, Franca Taviti
The last decades was characterized by a worldwide increasing incidence in melanoma. Almost 35% of diagnosed with melanoma women are in childbearing age. Malignant melanoma is the most common malignancy during pregnancy. Considering this background it is clear how melanoma and pregnancy has becoming one of the main topic of discussion. Current knowledge about pregnancy and melanoma are characterized by many controversies and divergences. The real incidence of melanoma in childbearing and the impact of pregnancy on the prognosis of melanoma is still unclear...
January 24, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28107260/frequency-of-pregnancy-related-cancer-a-population-based-linkage-study-in-lombardy-italy
#11
Fabio Parazzini, Matteo Franchi, Alessandra Tavani, Eva Negri, Fedro Alessandro Peccatori
OBJECTIVES: The aims of this study were to estimate the occurrence of pregnancy-associated cancer overall and by site, to evaluate if the risk increases over time, and to investigate some major determinants. METHODS: This is a population-based linkage study using the regional hospital discharge forms [Scheda di Dimissione Ospedaliera (SDO)] database of Lombardy, Italy, a region with 10 million inhabitants. All resident women with a SDO reporting a birth or abortion between 2001 and 2012 were identified...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28099365/melanoma-during-pregnancy-a-report-of-60-pregnancies-complicated-by-melanoma
#12
Jorine de Haan, Christianne A Lok, Christianne J de Groot, Marianne B Crijns, Kristel Van Calsteren, Karina Dahl Steffensen, Michael J Halaska, Sevilay Altintas, Ingrid A Boere, Robert Fruscio, Wojciech Kolawa, Petronella O Witteveen, Frédéric Amant
The management of melanoma during pregnancy is challenging as maternal benefits and fetal risks need to be balanced. Here, we present an overview of the incidence, the demographic and clinical characteristics and the treatment modalities used. After analysis of obstetric, fetal and maternal outcome, recommendations for clinical practice are provided. From the 'International Network on Cancer, Infertility and Pregnancy' database, pregnant patients with melanoma were identified and analysed. Sixty pregnancies were eligible for analysis...
June 2017: Melanoma Research
https://www.readbyqxmd.com/read/28058467/-treatment-of-melanoma-during-pregnancy
#13
REVIEW
L A Schneider
Melanoma diagnosed during pregnancy is a rare clinical case presentation which must be mastered. In the absence of guidelines for this clinical challenge, we performed a review of the literature and provide a practical guideline on how to manage such rare clinical cases based on our clinical experience. Expecting mothers require adequate counselling and explanation of all therapeutic options as they take responsibility for more than their own lives. However, they should be guided through the process of diagnostic and therapeutic measures in a potentially life-threatening situation...
January 5, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28003813/context-specific-and-immune-cell-dependent-antitumor-activities-of-%C3%AE-1-antitrypsin
#14
Ofer Guttman, Gabriella S Freixo-Lima, Ziv Kaner, Yotam Lior, Peleg Rider, Eli C Lewis
α1-antitrypsin (AAT), a circulating glycoprotein that rises during acute phase responses and healthy pregnancies, exhibits immunomodulatory properties in several T-cell-dependent immune pathologies. However, AAT does not directly interfere with T-cell responses; instead, it facilitates polarization of macrophages and dendritic cells towards M2-like and tolerogenic cells, respectively. AAT also allows NK cell responses against tumor cells, while attenuating DC-dependent induction of autoimmune NK cell activities...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27990727/coupling-sensitive-nucleic-acid-amplification-with-commercial-pregnancy-test-strips
#15
Yan Du, Arti Pothukuchy, Jimmy D Gollihar, Armin Nourani, Bingling Li, Andrew D Ellington
The detection of nucleic acid biomarkers for point-of-care (POC) diagnostics is currently limited by technical complexity, cost, and time constraints. To overcome these shortcomings, we have combined loop-mediated isothermal amplification (LAMP), programmable toehold-mediated strand-exchange signal transduction, and standard pregnancy test strips. The incorporation of an engineered hCG-SNAP fusion reporter protein (human chorionic gonadotropin-O(6) -alkylguanine-DNA alkyltransferase) led to LAMP-to-hCG signal transduction on low-cost, commercially available pregnancy test strips...
January 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/27926637/pigmentation-and-pregnancy-knowing-what-is-normal
#16
Amy Kalowitz Bieber, Kathryn J Martires, Jennifer A Stein, Jane M Grant-Kels, Marcia S Driscoll, Miriam Keltz Pomeranz
Changes in melanocytic nevi during pregnancy are frequently attributed to the new hormonal milieu and are dismissed without concern for malignancy. Recent studies suggest that pregnancy itself does not induce significant change in nevi, and delays in the assessment of changing moles may contribute to the often more advanced nature of melanomas diagnosed during or soon after pregnancy. Nevi on the breasts and abdomen can grow as a result of skin expansion, but studies have found no significant changes in nevi located in more stable areas such as the back or lower extremities...
January 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27893540/eight-years-experience-of-sentinel-lymph-node-biopsy-in-melanoma-using-lymphoscintigraphy-and-gamma-probe-detection-after-radiocolloid-mapping
#17
Nathalie Pham Dang, Sophie Cassier, Aurélien Mulliez, Sandrine Mansard, Michel DʼIncan, Isabelle Barthélémy
BACKGROUND: Isosulfan blue dye peripheral injection is used in preoperative sentinel lymph node (SLN) identification alone or, to increase sensitivity, in conjunction with radiocolloid mapping. However, isosulfan blue dye has certain drawbacks and limitations. OBJECTIVE: This study assesses the authors' experience of SLN biopsy using only radiocolloid tracer. MATERIALS AND METHODS: Between 2000 and 2008, 218 patients underwent SLN biopsy with radiocolloid mapping, preoperative localization by lymphoscintigraphy and intraoperative confirmation by gamma probe in primary malignant cutaneous melanoma...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27843602/cancer-in-pregnancy-disentangling-treatment-modalities
#18
REVIEW
Flora Zagouri, Constantine Dimitrakakis, Spyridon Marinopoulos, Alexandra Tsigginou, Meletios-Athanassios Dimopoulos
Pregnancy-associated cancer constitutes an uncommon and difficult to manage clinical situation. It is defined as the cancer diagnosed from the first day of childbearing to 1 year post partum. Coexistence of cancer with pregnancy adds complexity to treatment recommendations, as both the mother and the fetus may be affected. The optimal therapeutic management of pregnant women with cancer diagnosis should take into account, apart from medical factors, a host of other parameters (ethical, psychological, religious, legal, etc)...
2016: ESMO Open
https://www.readbyqxmd.com/read/27718538/pregnancy-as-driver-for-melanoma
#19
G Richtig, L Byrom, R Kupsa, H Schaider, R Hofmann-Wellenhof, I H Wolf, H P Soyer, E Richtig
Whether or not pregnancy favours the occurrence and growth of melanoma is a source of controversy in the literature. Several case reports have shown dramatic courses of diseases in pregnancy. We present a case of a 36-year-old woman with multiple naevi with one melanoma detected in 2009 in the first trimester and a second primary melanoma in 2010 in the third trimester of her pregnancy. Both lesions have been present for at least 5 years and have been interpreted as dysplastic naevi. Because of their growth during pregnancy they were removed...
October 8, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27647981/gynaecological-cancers-coexisting-with-pregnancy-a-literature-review
#20
REVIEW
Anna Skrzypczyk-Ostaszewicz, Maryna Rubach
The coexistence of malignant tumour and pregnancy is a state of simultaneous occurrence of two completely contradictory philosophical and biological phenomena - the development of a new life and a life-threatening terminal illness. Finally, a physician - in fact the whole team of doctors - is facing the fight for two lives: of the mother and her unborn child. The incidence of malignant disease in pregnancy is 0.05 to 0.1%. This condition is a major challenge for physicians because there are no randomised studies that could be the basis to choose the therapeutic methods - the medical knowledge merely comes from case reports, registries, and observational studies...
2016: Contemporary Oncology Współczesna Onkologia
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