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https://www.readbyqxmd.com/read/29107617/assessment-of-preclinical-pharmacokinetics-and-acute-toxicity-of-pioglitazone-and-telmisartan-combination
#1
Pinaki Sengupta, Bappaditya Chatterjee, Tapan Kumar Pal
The prevalence of hypertension is very common amongst the diabetic patients and is reported as the major cause of mortality in diabetes. Pioglitazone reported to have an ability to alter the blood cholesterol level and cardioprotective efficiency along with its antidiabetic activity. Telmisartan, through activation of PPAR-γ receptor exerts insulin sensitizing property in addition to its primary cardioprotective efficiency. Theoretically, a combination of pioglitazone and telmisartan may be beneficial to effectively control the high blood glucose level and management of coexisting cardiovascular complication in diabetes...
October 28, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28971841/role-of-myeloperoxidase-in-abdominal-aortic-aneurysm-formation-mitigation-by-taurine
#2
Ha Won Kim, Andra L Blomkalns, Mourad Ogbi, Manesh Thomas, Daniel Gavrila, Bonnie S Neltner, Lisa A Cassis, Robert W Thompson, Robert M Weiss, Paul D Lindower, Victor M Blanco, Michael L McCormick, Alan Daugherty, Xiaoming Fu, Stanley L Hazen, Brian K Stansfield, Yuqing Huo, David J R Fulton, Tapan Chatterjee, Neal L Weintraub
Oxidative stress plays a fundamental role in abdominal aortic aneurysm (AAA) formation. Activated polymorphonuclear leukocytes (PMNs or neutrophils) are associated with AAA and express myeloperoxidase (MPO), which promotes inflammation, matrix degradation and other pathological features of AAA including enhanced oxidative stress through generation of reactive oxidant species. Both plasma and aortic MPO levels are elevated in patients with AAA, but the role of MPO in AAA pathogenesis has heretofore never been investigated...
September 29, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28843265/poly-l-lysine-inhibits-tumor-angiogenesis-and-induces-apoptosis-in-ehrlich-ascites-carcinoma-and-in-sarcoma-s-180-tumor
#3
Souvik Debnath, Saumen Karan, Manish Debnath, Jyotirmayee Dash, Tapan Kumar Chatterjee
Background: This study focuses on the role of Poly-L-lysine (PLL), an essential amino acid, on molecular changes of tumor angiogenesis suppression, pro-apoptotic and anti-apoptotic gene expression after treatment on Ehrlich ascites carcinoma (EAC) and solid sarcoma-180 tumor cells bearing mice. Materials and Methods: The cell viability was carried out using MTT assay. The antitumor activity was evaluated by treatment with PLL at 20 and 40mg/kg/b.w doses for 14 days in EAC ascites tumor and 21 days for Sarcoma-180 solid tumor model...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28730622/susceptibility-to-hiv-1-infection-is-influenced-by-toll-like-receptor-2-196-to-174-polymorphism-in-north-indian-population
#4
Sanjukta Vidyant, Animesh Chatterjee, Vikas Agarwal, Tapan N Dhole
INTRODUCTION: Toll like receptors (TLRs) are pattern recognition receptors, recognize molecular patterns of pathogens and play an important role in innate immunity. Recent studies have identified that single nucleotide polymorphism (SNPs) in TLR gene impairs the response to TLR ligands in some individuals and is associated with susceptibility to various infectious diseases. AIM: The aim of the present study is to investigate the role of four SNPs in the TLR2 gene, -196 to -174 Ins/Del, 2258 G/A (Arg753Gln), 2029 C/T (Arg677Trp) and 1892 C/A (Pro631His) with susceptibility and progression to HIV-1 in North Indian individuals...
July 20, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28463989/identifying-sources-pathways-and-risk-drivers-in-ecosystems-of-japanese-encephalitis-in-an-epidemic-prone-north-indian-district
#5
Manish Kakkar, Sanjay Chaturvedi, Vijay Kumar Saxena, Tapan N Dhole, Ashok Kumar, Elizabeth T Rogawski, Syed Abbas, Vidya V Venkataramanan, Pranab Chatterjee
Japanese Encephalitis (JE) has caused repeated outbreaks in endemic pockets of India. This study was conducted in Kushinagar, a highly endemic district, to understand the human-animal-ecosystem interactions, and the drivers that influence disease transmission. Utilizing the ecosystems approach, a cross-sectional, descriptive study, employing mixed methods design was employed. Four villages (two with pig-rearing and two without) were randomly selected from a high, a medium and a low burden (based on case counts) block of Kushinagar...
2017: PloS One
https://www.readbyqxmd.com/read/28344828/lc-ms-ms-assay-for-quantitation-of-enalapril-and-enalaprilat-in-plasma-for-bioequivalence-study-in-indian-subjects
#6
Dhiman Halder, Shubhasis Dan, Murari Mohun Pal, Easha Biswas, Nilendra Chatterjee, Pradipta Sarkar, Umesh Chandra Halder, Tapan Kumar Pal
BACKGROUND: Enalapril (EPL) is an angiotensin-converting enzyme inhibitor for the treatment of hypertension and chronic heart failure. Enalaprilat (EPLT) is an active metabolite that contributes to the overall activity of EPL. AIM: To quantitate EPL along with its metabolite EPLT using LC-MS/MS, a bioanalytical method was developed and validated with tolbutamide in human plasma using a protein precipitation technique. RESULTS: The sensitive and selective method has an LLOQ of 1 ng/ml with a linearity range of 1-500 ng/ml for both EPL and EPLT using 300 µl of plasma without any matrix effect...
March 2017: Future Science OA
https://www.readbyqxmd.com/read/28242765/a-novel-role-for-the-wnt-inhibitor-apcdd1-in-adipocyte-differentiation-implications-for-diet-induced-obesity
#7
Nicole K H Yiew, Tapan K Chatterjee, Yao Liang Tang, Rod Pellenberg, Brian K Stansfield, Zsolt Bagi, David J Fulton, David W Stepp, Weiqin Chen, Vijay Patel, Vinayak M Kamath, Sheldon E Litwin, David Y Hui, Steven M Rudich, Ha Won Kim, Neal L Weintraub
Impaired adipogenic differentiation during diet-induced obesity (DIO) promotes adipocyte hypertrophy and inflammation, thereby contributing to metabolic disease. Adenomatosis polyposis coli down-regulated 1 (APCDD1) has recently been identified as an inhibitor of Wnt signaling, a key regulator of adipogenic differentiation. Here we report a novel role for APCDD1 in adipogenic differentiation via repression of Wnt signaling and an epigenetic linkage between miR-130 and APCDD1 in DIO. APCDD1 expression was significantly up-regulated in mature adipocytes compared with undifferentiated preadipocytes in both human and mouse subcutaneous adipose tissues...
April 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28128864/aliphatic-c-c-bond-cleavage-in-%C3%AE-hydroxy-ketones-by-a-dioxygen-derived-nucleophilic-iron-oxygen-oxidant
#8
Shrabanti Bhattacharya, Rubina Rahaman, Sayanti Chatterjee, Tapan K Paine
A nucleophilic iron-oxygen oxidant, formed in situ in the reaction between an iron(II)-benzilate complex and O2 , oxidatively cleaves the aliphatic C-C bonds of α-hydroxy ketones. In the cleavage reaction, α-hydroxy ketones without any α-C-H bond afford a 1:1 mixture of carboxylic acid and ketone. Isotope labeling studies established that one of the oxygen atoms from dioxygen is incorporated into the carboxylic acid product. Furthermore, the iron(II) complex cleaves an aliphatic C-C bond of 17-α-hydroxyprogesterone affording androstenedione and acetic acid...
January 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28068635/inositol-hexa-phosphoric-acid-phytic-acid-a-nutraceuticals-attenuates-iron-induced-oxidative-stress-and-alleviates-liver-injury-in-iron-overloaded-mice
#9
Anwesha Bhowmik, Durbadal Ojha, Debayan Goswami, Rashmi Das, Nidhi S Chandra, Tapan K Chatterjee, Amit Chakravarty, Sudipa Chakravarty, Debprasad Chattopadhyay
Inositol hexa phosphoric acid (IP6) or Phytic acid, a natural antioxidant of some leguminous plants, known to act as a protective agent for seed storage in plants by suppressing iron catalyzed oxidative process. Following the same mechanism, we have tested the effect of IP6 on iron overloaded in vitro oxidative stress, and studied it's in vivo hepatoprotective ability in iron-dextran (injection)-induced iron overloaded liver injury in mice (intraperitoneal). Our results showed that IP6 had in vitro iron chelation (IC50 38...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27398481/use-of-spectroscopic-techniques-to-reveal-the-nature-of-the-interactions-of-two-sialic-acid-specific-lectins-with-gold-nanoparticles
#10
Shuvendu Singha, Gopa Dutta, Partha P Bose, Subrata Das, Munmun Bardhan, Bishnu P Chatterjee, Tapan Ganguly
From UV-vis absorption, steady state and time resolved fluorescence measurements coupled with circular dichroism (CD) spectral studies, it was revealed that among the two lectins: Sambucus nigra agglutinin (SNA) and Saraca indica (saracin II), SNA forms stronger binding complex in the ground state with gold nanoparticles (GNPs). From the measurements of Stern-Volmer (SV) constants Ksv, and binding constants K(A) and number of binding sites two important inferences could be drawn. Firstly, the fluorescence quenching is primarily due to static quenching and secondly SNA forms stronger binding with GNPs relative to the other lectin saracin II...
January 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27148606/substrate-dependent-aromatic-ring-fission-of-catechol-and-2-aminophenol-with-o2-catalyzed-by-a-nonheme-iron-complex-of-a-tripodal-n4-ligand
#11
Triloke Ranjan Lakshman, Sayanti Chatterjee, Biswarup Chakraborty, Tapan Kanti Paine
The catalytic reactivity of an iron(ii) complex [(TPA)Fe(II)(CH3CN)2](2+) (1) (TPA = tris(2-pyridylmethyl)amine) towards oxygenative aromatic C-C bond cleavage of catechol and 2-aminophenol is presented. Complex 1 exhibits catalytic and regioselective C-C bond cleavage of 3,5-di-tert-butylcatechol (H2DBC) to form intradiol products, whereas it catalyzes extradiol-type C-C bond cleavage of 2-amino-4,6-di-tert-butylphenol (H2AP). The catalytic reactions are found to be pH-dependent and the complex exhibits maximum turnovers at pH 5 in acetonitrile-phthalate buffer...
June 7, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/26828771/linker-induced-structural-diversity-and-photophysical-property-of-mofs-for-selective-and-sensitive-detection-of-nitroaromatics
#12
Tapan K Pal, Nabanita Chatterjee, Parimal K Bharadwaj
The linker [1,1':3',1″-terphenyl]-4,4',4″,6'-tetracarboxylic acid (H4L) was used to construct two three-dimensional (3D) metal-organic frameworks (MOFs), namely, {[Cd2(L)(L1)(DMF)(H2O)](2DMF)(3H2O)}n (1) and {[Cd4(L)2(L2)3(H2O)2](8DMF)(8H2O)}n (2) (DMF = N,N'-dimethylformamide) in the presence of colinkers 4,4'-bipyridine (L1) and 2-amino-4,4'-bipyridine (L2), respectively, under solvothermal condition. A small change in the colinker leads to significant differences in the overall structure of the MOFs...
February 15, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/26822989/hydroxylation-versus-halogenation-of-aliphatic-c-h-bonds-by-a-dioxygen-derived-iron-oxygen-oxidant-functional-mimicking-of-iron-halogenases
#13
Sayanti Chatterjee, Tapan Kanti Paine
An iron-oxygen intermediate species generated in situ in the reductive activation of dioxygen by an iron(II)-benzilate complex of a monoanionic facial N3 ligand, promoted the halogenation of aliphatic C-H bonds in the presence of a protic acid and a halide anion. An electrophilic iron(IV)-oxo oxidant with a coordinated halide is proposed as the active oxidant. The halogenation reaction with dioxygen and the iron complex mimics the activity of non-heme iron halogenases.
June 27, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/26467254/red-blood-cell-dysfunction-induced-by-high-fat-diet-potential-implications-for-obesity-related-atherosclerosis
#14
Dusten Unruh, Ramprasad Srinivasan, Tyler Benson, Stephen Haigh, Danielle Coyle, Neil Batra, Ryan Keil, Robert Sturm, Victor Blanco, Mary Palascak, Robert S Franco, Wilson Tong, Tapan Chatterjee, David Y Hui, W Sean Davidson, Bruce J Aronow, Theodosia Kalfa, David Manka, Abigail Peairs, Andra Blomkalns, David J Fulton, Julia E Brittain, Neal L Weintraub, Vladimir Y Bogdanov
BACKGROUND: High-fat diet (HFD) promotes endothelial dysfunction and proinflammatory monocyte activation, which contribute to atherosclerosis in obesity. We investigated whether HFD also induces the dysfunction of red blood cells (RBCs), which serve as a reservoir for chemokines via binding to Duffy antigen receptor for chemokines (DARC). METHODS AND RESULTS: A 60% HFD for 12 weeks, which produced only minor changes in lipid profile in C57/BL6 mice, markedly augmented the levels of monocyte chemoattractant protein-1 bound to RBCs, which in turn stimulated macrophage migration through an endothelial monolayer...
November 17, 2015: Circulation
https://www.readbyqxmd.com/read/26317058/role-of-histone-deacetylase-9-in-regulating-adipogenic-differentiation-and-high-fat-diet-induced-metabolic-disease
#15
Tapan K Chatterjee, Joshua E Basford, Kan Hui Yiew, David W Stepp, David Y Hui, Neal L Weintraub
Adipose tissue serves as both a storage site for excess calories and as an endocrine organ, secreting hormones such as adiponectin that promote metabolic homeostasis. In obesity, adipose tissue expands primarily by hypertrophy (enlargement of existing adipocytes) rather than hyperplasia (generation of new adipocytes via adipogenic differentiation of preadipocytes). Progressive adipocyte hypertrophy leads to inflammation, insulin resistance, dyslipidemia, and ectopic lipid deposition, the hallmark characteristics of metabolic disease...
October 2014: Adipocyte
https://www.readbyqxmd.com/read/26183616/histone-deacetylases-and-cardiometabolic-diseases
#16
REVIEW
Kan Hui Yiew, Tapan K Chatterjee, David Y Hui, Neal L Weintraub
Cardiometabolic disease, emerging as a worldwide epidemic, is a combination of metabolic derangements leading to type 2 diabetes mellitus and cardiovascular disease. Genetic and environmental factors are linked through epigenetic mechanisms to the pathogenesis of cardiometabolic disease. Post-translational modifications of histone tails, including acetylation and deacetylation, epigenetically alter chromatin structure and dictate cell-specific gene expression patterns. The histone deacetylase family comprises 18 members that regulate gene expression by altering the acetylation status of nucleosomal histones and by functioning as nuclear transcriptional corepressors...
September 2015: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/26107050/comparison-of-redox-activity-between-2-aminothioether-and-2-aminothiophenol-redox-induced-dimerization-of-2-aminothioether-via-c-c-coupling
#17
Pradip Ghosh, Sutanuva Mandal, Ipsita Chatterjee, Tapan Kumar Mondal, Sreebrata Goswami
Three chemical reactions of two 2-aminothioethers and 2-aminothiophenol with CpRu(II)Cl(PPh3)2 (Cp(-) = cyclopentadienyl anion), under identical reaction conditions, are reported. While 2-(methylthio)aniline, H2L(1) and an analogous substrate, 2-(phenylthio)aniline yielded dicationic dinuclear complexes [(PPh3)CpRu(II)(L(3/)L(4))Ru(II)Cp(PPh3)]Cl2 (where L(3) = (4E)-4-(4-imino-3-(methylthio)cyclohexa-2,5-dienylidene)-2-(methylthio)cyclohexa-2,5-dienimine ([1a]Cl2) and L(4) = (4E)-4-(4-imino-3-(phenylthio)cyclohexa-2,5-dienylidene)-2-(phenylthio)cyclohexa-2,5-dienimine ([1b]Cl2)), the reaction with 2-aminothiophenol (H2L(2)) produced a mononuclear complex [(PPh3)CpRu(II)(L(2))]Cl (where L(2) = 6-iminocyclohexa-2,4-dienethione) ([2]Cl)...
July 6, 2015: Inorganic Chemistry
https://www.readbyqxmd.com/read/26088714/olefin-cis-dihydroxylation-and-aliphatic-c-h-bond-oxygenation-by-a-dioxygen-derived-electrophilic-iron-oxygen-oxidant
#18
Sayanti Chatterjee, Tapan Kanti Paine
Many iron-containing enzymes involve metal-oxygen oxidants to carry out O2-dependent transformation reactions. However, the selective oxidation of C-H and C=C bonds by biomimetic complexes using O2 remains a major challenge in bioinspired catalysis. The reactivity of iron-oxygen oxidants generated from an Fe(II)-benzilate complex of a facial N3 ligand were thus investigated. The complex reacted with O2 to form a nucleophilic oxidant, whereas an electrophilic oxidant, intercepted by external substrates, was generated in the presence of a Lewis acid...
August 3, 2015: Angewandte Chemie
https://www.readbyqxmd.com/read/26000650/a-novel-triterpene-from-astraeus-hygrometricus-induces-reactive-oxygen-species-leading-to-death-in-leishmania-donovani
#19
Suvadip Mallick, Somaditya Dey, Supratim Mandal, Aritri Dutta, Debarati Mukherjee, Gunjan Biswas, Soumya Chatterjee, Sanjaya Mallick, Tapan Kumar Lai, Krishnendu Acharya, Chiranjib Pal
AIM: The effect of astrakurkurone, a novel triterpene, isolated from Indian mushroom Astraeus hygrometricus has been investigated to elucidate the mechanisms involved in selective cell death of Leishmania donovani. MATERIALS & METHODS: The hypotheses were investigated using flow-cytometry, scanning electron microscopy and confocal microscopy. RESULTS: The time dependent elevation of astrakurkurone-induced reactive oxygen species (ROS) was found intimately associated with apoptosis...
2015: Future Microbiology
https://www.readbyqxmd.com/read/25646806/oxygenative-aromatic-ring-cleavage-of-2-aminophenol-with-dioxygen-catalyzed-by-a-nonheme-iron-complex-catalytic-functional-model-of-2-aminophenol-dioxygenases
#20
Sayanti Chatterjee, Tapan Kanti Paine
2-Aminophenol dioxygenases catalyze the oxidative ring cleavage of 2-aminophenol to 2-picolinic acid using O2 as the oxidant. Inspired by the reaction catalyzed by these nonheme iron enzymes, a biomimetic iron(III)-2-amidophenolate complex, [(tBu-L(Me))Fe(III)(4,6-di-tBu-AP)](ClO4) (1a) of a facial tridentate ligand (tBu-L(Me) = 1-[bis(6-methyl-pyridin-2-yl)-methyl]-3-tert-butyl-urea and 4,6-di-tBu-H2AP = 2-amino-4,6-di-tert-butylphenol) bearing a urea group have been isolated. The complex reacts with O2 to cleave the C-C bond of 4,6-di-tBu-AP regioselectively and catalytically to afford 4,6-di-tert-butyl-2-picolinic acid...
February 16, 2015: Inorganic Chemistry
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