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https://www.readbyqxmd.com/read/28737968/pattern-of-tumor-shrinkage-during-neoadjuvant-chemotherapy-is-associated-with-prognosis-in-low-grade-luminal-early-breast-cancer
#1
Ippei Fukada, Kazuhiro Araki, Kokoro Kobayashi, Tomoko Shibayama, Shunji Takahashi, Naoya Gomi, Yumi Kokubu, Katsunori Oikado, Rie Horii, Futoshi Akiyama, Takuji Iwase, Shinji Ohno, Kiyohiko Hatake, Naohiro Sata, Yoshinori Ito
Purpose To evaluate the association between tumor shrinkage patterns shown with magnetic resonance (MR) imaging during neoadjuvant chemotherapy (NAC) and prognosis in patients with low-grade luminal breast cancer. Materials and Methods This retrospective study was approved by the institutional review board and informed consent was obtained from all subjects. The low-grade luminal breast cancer was defined as hormone receptor-positive and human epidermal growth factor receptor 2-negative with nuclear grades 1 or 2...
July 24, 2017: Radiology
https://www.readbyqxmd.com/read/28737925/lipid-bilayer-gated-mesoporous-silica-nanocarriers-for-tumor-targeted-delivery-of-zoledronic-acid-in-vivo
#2
Diti Desai, Jixi Zhang, Jouko Sandholm, Jaakko Lehtimäki, Tove Grönroos, Johanna Tuomela, Jessica M Rosenholm
Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate used for the treatment of bone diseases and calcium metabolism. Anticancer activity of ZOL has been established, but its extraskeletal effects are limited due to its rapid uptake and accumulation to bone hydroxyapatite. In this work, we report on the development of tethered lipid bilayer-gated mesoporous silica nanocarriers (MSNs) for the incorporation, retention and intracellular delivery of ZOL. The in vitro anticancer activity of ZOL-loaded nanocarriers was evaluated by cell viability assay and live-cell imaging...
July 24, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28736788/characterisation-of-anticancer-peptides-at-the-single-cell-level
#3
L Armbrecht, G Gabernet, F Kurth, J A Hiss, G Schneider, P S Dittrich
The development of efficacious anticancer therapeutics is difficult due to the heterogeneity of the cellular response to chemotherapy. Anticancer peptides (ACPs) are promising drug candidates that have been shown to be active against a range of cancer cells. However, few ACP studies focus on tumour single-cell heterogeneities. In order to address this need, we developed a microfluidic device and an imaging procedure that enable the capture, monitoring, and analysis of several hundred single cells for the study of drug response...
July 24, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28736367/-establishment-of-mouse-model-of-bone-metastasis-of-prostate-cancer-and-breast-cancer-via-femoral-artery-injection-of-tumor-cells
#4
Zhao-Yang Yin, Si-Yong Qi, Xiang Cheng, Liang Guo, Hong-Yu Chen, Ming Shi
OBJECTIVE: To explore an efficient and reliable method for establishing an animal model of bone metastasis of tumors. METHODS: Male C57BL/6J mice were randomized into 4 equal groups to receive injections of normal saline or prostate cancer RM-1 cell suspension via the femoral artery or the external iliac artery, and breast cancer 4T1-luc cells were injected in 15 female BALB/c mice via the femoral artery. The operation time, postoperative survival rate, and the tumor formation rates in the mice with two different injection methods were compared...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28734571/multimodal-ultrasound-computer-assisted-tomography-an-approach-to-the-recognition-of-breast-lesions
#5
Krzysztof J Opieliński, Piotr Pruchnicki, Paweł Szymanowski, Wioletta K Szepieniec, Hanna Szweda, Elżbieta Świś, Marcin Jóźwik, Michał Tenderenda, Mariusz Bułkowski
The research here presented aims at developing a new, promising method for the imaging diagnostics of breast lesions - ultrasound tomography (UST). A currently implemented device enables the reconstruction three complementary images for each coronal breast section. Based on in vivo breast examination, the authors developed an approach to breast diagnostics which employs ultrasound transmission and reflection tomography imaging. The obtained transmission images of ultrasound speed distribution show good correlation of glandular tissue areas with their visualization on MRI images...
July 3, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28733706/phage-display-selection-in-vitro-characterization-and-correlative-pet-imaging-of-a-novel-her3-peptide
#6
Benjamin M Larimer, Nicholas Phelan, Eric Wehrenberg-Klee, Umar Mahmood
PURPOSE: HER3 (ERBB3) is a receptor tyrosine kinase that is implicated in treatment resistance across multiple cancers, including those of the breast, lung, and prostate. Overexpression of HER3 following targeted therapy can occur rapidly and heterogeneously both within a single lesion and across sites of metastasis, making protein quantification by biopsy highly challenging. A global, non-invasive methodology such as positron emission tomography (PET) imaging can permit serial quantification of HER3, providing a useful approach to monitor HER3 expression across the entire tumor burden both prior to and following treatment...
July 21, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28733539/cancer-antigen-15-3-platelet-distribution-width-and-fibrinogen-in-combination-to-distinguish-breast-cancer-from-benign-breast-disease-in-non-conclusive-mammography-patients
#7
Shuang Fu, Zhi-Yuan Yun, Ming-Ming Cui, Hongxue Meng, Cheng Qian, Tiemin Liu, Zhi-Ping Liu, Rui-Tao Wang, Kai-Jiang Yu
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females. However, mammographic diagnosis is sometimes non-conclusive with a Breast imaging Reporting and Data System (Bi-RaDS) result of 0. Cancer antigen 15-3 (CA15-3) is the most widely used serum tumor marker for breast cancer screening. Platelet distribution width (PDW) is an early indicator of platelet activation. Fibrinogen contributed to angiogenesis and distant metastasis. The aim of this study was to investigate the ability of CA15-3, PDW, and fibrinogen individually or in combination, to distinguish breast cancer from benign breast disease...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732648/a-systematic-review-of-women-s-satisfaction-and-regret-following-risk-reducing-mastectomy
#8
REVIEW
Lucy Braude, Laura Kirsten, Jemma Gilchrist, Ilona Juraskova
OBJECTIVE: A systematic review of quantitative and qualitative studies, to describe patient satisfaction and regret associated with risk-reducing mastectomies (RRM), and the patient-reported factors associated with these among women at high risk of developing breast cancer. METHODS: Studies were identified using Medline, CINAHL, Embase and PsycInfo databases (1995-2016). Data were extracted and crosschecked for accuracy. Article quality was assessed using standardised criteria...
July 1, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28731491/patient-satisfaction-and-acceptance-of-their-totally-implanted-central-venous-catheter-a-french-prospective-multicenter-study
#9
Pierre-Yves Marcy, Renaud Schiappa, Jean-Marc Ferrero, Christian Dahlet, Olivier Brenet, Gabriel Yazbec, Pierre-Yves Dubois, Bernard Salm, Yves Fouche, Veronique Mari, Marion Montastruc, Nathalie Lebrec, Benoit Ancel, Nicolas Paillocher, Denis Dupoiron, Olivier Rangeard, Jocelyn Gal, Marc Ettaiche, Yann Chateau, Emmanuel Chamorey
INTRODUCTION: Most cancer patients require a totally implanted central venous catheter (TIVAD) for their treatment. In a previous study, we developed and validated a questionnaire dubbed QASICC (Questionnaire for Acceptance of, and Satisfaction with, Implanted Central Venous Catheter) assessing patient satisfaction with, and acceptance of, their TIVAD. In the present study, we conducted a large, prospective, multicenter study in cancer patients aimed to analyze factors that could influence patients' acceptance of, and satisfaction with, their device...
July 19, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28730339/breast-cancer-neoplastic-seeding-in-the-setting-of-image-guided-needle-biopsies-of-the-breast
#10
REVIEW
Lumarie Santiago, Beatriz E Adrada, Monica L Huang, Wei Wei, Rosalind P Candelaria
PURPOSE: To identify clinicopathologic, technical, and imaging features associated with neoplastic seeding (NS) following image-guided needle breast biopsy. METHODS: We performed an institutional review board-approved retrospective review of patients presenting with a new diagnosis of breast cancer or suspicious breast findings requiring biopsy with subsequent diagnosis of NS. The time from biopsy to NS diagnosis was calculated. Histology, grade, estrogen receptor (ER) status, progesterone receptor (PR) status, HER2 status, T category, and N category were recorded...
July 20, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28729183/differentiation-between-idiopathic-granulomatous-mastitis-and-malignant-breast-lesions-using-strain-ratio-on-ultrasonic-elastography
#11
B Yağcı, I Erdem Toslak, B Çekiç, M Öz, B R Karakaş, M Akdemir, S Yıldız, D Süren, D Bova
PURPOSE: The goal of this study was to investigate the strain elastography imaging characteristics of idiopathic granulomatous mastitis (IGM) and compare strain ratio values of IGM with those of breast cancer. MATERIAL AND METHODS: Twenty-three consecutive women with IGM (mean age, 37.9±6.6 [SD] years; range: 26-52 years) and 45 women with malignant breast tumor (mean age, 52.8±12.0 [SD], range, 32-77 years) who had been scheduled for ultrasound-guided core biopsy were recruited to the study...
July 17, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28728883/long-term-survival-outcomes-of-primary-breast-cancer-in-women-with-or-without-preoperative-magnetic-resonance-imaging-a%C3%A2-matched-cohort-study
#12
W J Choi, J H Cha, H H Kim, H J Shin, E Y Chae, K H Jung, J-H Ahn, S-B Kim, B H Son, S H Ahn
AIMS: To investigate whether preoperative magnetic resonance imaging (MRI) in patients with primary breast cancer is predictive of disease-free (DFS) and overall survival and to determine the prognostic factors indicating survival. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board and the requirement for informed consent was waived. From 2009 to 2010, 828 women with primary breast cancer and preoperative MRI were matched with 1613 women without such imaging...
July 17, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28728876/is-technetium-99m-sestamibi-imaging-able-to-predict-pathologic-nonresponse-to-neoadjuvant-chemotherapy-in-breast-cancer-a-meta-analysis-evaluating-current-use-and-shortcomings
#13
Angela Collarino, Elizabeth J de Koster, Renato A Valdés Olmos, Lioe-Fee de Geus-Oei, Lenka M Pereira Arias-Bouda
BACKGROUND: Interest in technetium-99m ((99m)Tc)-sestamibi imaging for neoadjuvant chemotherapy (NAC) response monitoring in locally advanced breast cancer (LABC) is increasing but remains matter of discussion. The present study conducted a meta-analysis of the diagnostic performance of (99m)Tc-sestamibi to predict pathologic nonresponse to NAC for primary LABC. MATERIALS AND METHODS: A systematic data search was performed. Studies with a minimum of 10 LABC patients that had evaluated (99m)Tc-sestamibi imaging for NAC nonresponse using conventional planar scintimammography, breast-specific γ-imaging, and/or single photon emission computed tomography/computed tomography (SPECT/CT) were included...
June 29, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28727573/diffusion-weighted-mr-imaging-in-prediction-of-response-to-neoadjuvant-chemotherapy-in-patients-with-breast-cancer
#14
Xue-Ying Hu, Ying Li, Guan-Qiao Jin, Shao-Lv Lai, Xiang-Yang Huang, Dan-Ke Su
This study aims to evaluate the potential of apparent diffusion coefficient (ADC) derived from diffusion-weighted MR imaging for predicting the treatment response to neoadjuvant chemotherapy (NACT) in patients with breast cancer. Magnetic resonance imaging was performed prior to NACT and after two cycles of NACT. The correlation between mean ADCpre values, mean ADCpost values, changes in ADC values and changes in tumor diameters after NACT was examined using Spearman rank correlation. A total of 164 breast cancers were enrolled in this study...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28727561/a-cots-based-microwave-imaging-system-for-breast-cancer-detection
#15
Mario R Casu, Marco Vacca, Jorge A Tobon, Azzurra Pulimeno, Imran Sarwar, Raffaele Solimene, Francesca Vipiana
Microwave imaging is an emerging breast cancer diagnostic technique, which aims at complementing already established methods like mammography, magnetic resonance imaging, and ultrasound. It offers two striking advantages: no-risk for the patient and potential low-cost for national health systems. So far, however, the prototypes developed for validation in labs and clinics used costly lab instruments such as a vector network analyzer (VNA). Moreover, the CPU time required by complex image reconstruction algorithms may not be compatible with the duration of a medical examination...
July 18, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28726673/off-on-fluorescence-monitoring-of-intracellular-ag-in-single-living-cells-using-an-ag-responsive-probe
#16
Jian Lv, Li-Jun Zhao, Ruo-Can Qian, Yi-Tao Long
Detection of silver ions (Ag+) in living cells has becoming more and more attractive due to the important biological impact of Ag+ on cellular functions. Here, we put forward a new approach to realize the in situ fluorescence imaging and detection of Ag+ in single cells via an ultrasensitive Ag+-responsive probe, 3', 6'-bis (diethylamino)-2-(2-iodoethyl) spiro[isoindoline-1, 9'-xanthen]-3-one (BDISIX). In the presence of Ag+, the fluorescence of the probe can be turned "on", generating strong red fluorescence...
July 20, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28726506/maximizing-value-through-innovations-in-radiologist-driven-communications-in-breast-imaging
#17
Christoph I Lee, Janie M Lee
OBJECTIVE: The purposes of this article are to provide an overview of current and emerging practices in radiologist communications with both referring physicians and patients across the breast cancer care continuum; to highlight areas in which radiologist-driven communications can improve value in breast cancer screening, diagnosis, and treatment; and describe how the integrative reporting and consultative practices of breast imagers can serve as models of higher-value patient-centered care in other radiology subspecialties...
July 20, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28726117/applying-a-new-bilateral-mammographic-density-segmentation-method-to-improve-accuracy-of-breast-cancer-risk-prediction
#18
Shiju Yan, Yunzhi Wang, Faranak Aghaei, Yuchen Qiu, Bin Zheng
PURPOSE: How to optimally detect bilateral mammographic asymmetry and improve risk prediction accuracy remains a difficult and unsolved issue. Our aim was to find an effective mammographic density segmentation method to improve accuracy of breast cancer risk prediction. METHODS: A dataset including 168 negative mammography screening cases was used. We applied a mutual threshold to bilateral mammograms of left and right breasts to segment the dense breast regions...
July 19, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28725587/multi-parametric-mri-imaging-of-the-prostate-implications-for-focal-therapy
#19
REVIEW
James S Wysock, Herbert Lepor
The primary goal of a focal therapy treatment paradigm is to achieve cancer control through targeted tissue destruction while simultaneously limiting deleterious effects on peri-prostatic structures. Focal therapy approaches are employed in several oncologic treatment protocols, and have been shown to provide equivalent cancer control for malignancies such as breast cancer and renal cell carcinoma. Efforts to develop a focal therapy approach for prostate cancer have been challenged by several concepts including the multifocal nature of the disease and limited capability of prostate ultrasound and systematic biopsy to reliably localize the site(s) and aggressiveness of disease...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28723286/association-between-computer-aided-diagnosis-measured-peak-enhancement-and-washout-component-at-preoperative-mr-imaging-and-operable-hormone-receptor-positive-breast-cancer
#20
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