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https://www.readbyqxmd.com/read/29159881/characterization-of-photon-counting-multi-slit-breast-tomosynthesis
#1
Karl Berggren, Björn Cederström, Mats Lundqvist, Erik Fredenberg
PURPOSE: It has been shown that breast tomosynthesis may improve sensitivity and specificity compared to 2D mammography, resulting in increased detection-rate of cancers or lowered call-back rates. The purpose of this study is to characterize a spectral photon-counting multi-slit breast tomosynthesis system that is able to do single-scan spectral imaging with multiple collimated x-ray beams. The system differs in many aspects compared to conventional tomosynthesis using energy-integrating flat-panel detectors...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29159811/a-deep-learning-method-for-classifying-mammographic-breast-density-categories
#2
Aly A Mohamed, Wendie A Berg, Hong Peng, Yahong Luo, Rachel C Jankowitz, Shandong Wu
PURPOSE: Mammographic breast density is an established risk marker for breast cancer and is visually assessed by radiologists in routine mammogram image reading, using four qualitative Breast Imaging and Reporting Data System (BI-RADS) breast density categories. It is particularly difficult for radiologists to consistently distinguish the two most common and most variably assigned BI-RADS categories, i.e., "scattered density" and "heterogeneously dense". The aim of this work was to investigate a deep learning-based breast density classifier to consistently distinguish these two categories, aiming at providing a potential computerized tool to assist radiologists in assigning a BI-RADS category in current clinical workflow...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29159779/simultaneous-whole-body-and-breast-18f-fdg-pet-mri-examinations-in-patients-with-breast-cancer-a-comparison-of-apparent-diffusion-coefficients-and-maximum-standardized-uptake-values
#3
Michiro Sasaki, Mitsuhiro Tozaki, Kazunori Kubota, Wakana Murakami, Daisuke Yotsumoto, Yasuaki Sagara, Yasuyo Ohi, Shunichi Oosako, Yoshiaki Sagara
PURPOSE: To compare standardized uptake value (SUV) and apparent diffusion coefficient (ADC) values acquired using a PET/MRI scanner in breast cancer patients. MATERIALS AND METHODS: Whole-body PET/MRI and breast PET/MRI were performed in 108 consecutive patients. Ninety-four patients who had a total of 100 breast cancers were analyzed. SUVmax and ADCmean acquired using breast PET/MRI were compared with pathologic prognostic factors. RESULTS: All the lesions were visually detectable using PET and diffusion-weighted imaging (DWI) on breast PET/MRI; however, lesions were visually undetectable on whole-body DWI in 13 patients (13%) or on whole-body PET in 7 patients (7%)...
November 20, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29158836/a-laser-activated-biocompatible-theranostic-nanoagent-for-targeted-multimodal-imaging-and-photothermal-therapy
#4
Liming Deng, Xiaojun Cai, Danli Sheng, Yang Yang, Eric M Strohm, Zhigang Wang, Haitao Ran, Dong Wang, Yuanyi Zheng, Pan Li, Tingting Shang, Yi Ling, Fengjuan Wang, Yang Sun
Multifunctional nanoparticles have been reported for cancer detection and treatment currently. However, the accurate diagnosis and efficient treatment for tumors are still not satisfied. Here we report on the development of targeted phase change multimodal polymeric nanoparticles for the imaging and treatment of HER2-positive breast cancer. METHODS: We evaluated the multimodal imaging capabilities of the prepared nanoparticles in vitro using agar-based phantoms. The targeting performance and cytotoxicity of the nanoparticles were examined in cell culture using SKBR3 (over-expressing HER2) and MDA-MB-231 (HER2 negative) cells...
2017: Theranostics
https://www.readbyqxmd.com/read/29158825/noninvasive-imaging-of-cd206-positive-m2-macrophages-as-an-early-biomarker-for-post-chemotherapy-tumor-relapse-and-lymph-node-metastasis
#5
Chenran Zhang, Xinhe Yu, Liquan Gao, Yang Zhao, Jianhao Lai, Dehua Lu, Rui Bao, Bing Jia, Lijun Zhong, Fan Wang, Zhaofei Liu
Tumor relapse after initial regression post-chemotherapy is a major challenge in cancer treatment, as it usually leads to local-regional recurrence or inoperable distant metastasis. M2 macrophages diminish the tumor-inhibitory effect of chemotherapy and correlate with distant metastasis and poor prognosis. In this study, we investigated whether molecular imaging of M2 macrophages could serve as an early biomarker for tumor relapse after chemotherapy and tumor lymph node metastasis in preclinical mouse models...
2017: Theranostics
https://www.readbyqxmd.com/read/29157453/computer-aided-tumor-diagnosis-in-3-d-breast-elastography
#6
Yao-Sian Huang, Etsuo Takada, Sachiyo Konno, Chiun-Shen Huang, Ming-Hao Kuo, Ruey-Feng Chang
BACKGROUND AND OBJECTIVE: Breast cancer is the major cause of cancer-related mortality in women. However, the death rate can be effectively decreased if the breast cancer can be detected early and treated appropriately. In recent years, many studies have indicated that the elastography has the better diagnosis performance than conventional ultrasound (US). METHOD: In this study, the 3-D tumor contour is obtained by using the proposed segmentation methods and then the features containing texture information, shape information, ellipsoid fitting information are extracted respectively by using the segmented 3-D tumor contour and B-mode images, and the features containing elasticity information are calculated using the same contour and elastographic images...
January 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29157313/calpain-5-gene-expression-in-the-mouse-eye-and-brain
#7
Kellie Schaefer, MaryAnn Mahajan, Anuradha Gore, Stephen H Tsang, Alexander G Bassuk, Vinit B Mahajan
OBJECTIVE: Our objective was to characterize CAPN5 gene expression in the mouse central nervous system. Mouse brain and eye sections were probed with two high-affinity RNA oligonucleotide analogs designed to bind CAPN5 RNA and one scramble, control oligonucleotide. Images were captured in brightfield. RESULTS: CAPN5 RNA probes were validated on mouse breast cancer tumor tissue. In the eye, CAPN5 was expressed in the ganglion cell, inner nuclear and outer nuclear layers of the retina...
November 21, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29156828/the-%C3%AE-glucan-from-lentinus-edodes-suppresses-cell-proliferation-and-promotes-apoptosis-in-estrogen-receptor-positive-breast-cancers
#8
Hui Xu, Siwei Zou, Xiaojuan Xu
Breast cancer is now the most common cancer in worldwide women, and novel interventions are needed to overcome the resistance occurring in the estrogen-targeted endocrine therapy. Herein, we demonstrate that the β-glucan from Lentinus edodes (LNT) exhibited a profound inhibition ratio of ∼53% against estrogen receptor positive (ER+) MCF-7 tumor growth in nude mice similar to the positive control of cisplatin. Immunohistochemistry images showed that LNT evidently suppressed cell proliferation and promoted apoptosis in MCF-7 tumor tissues...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156817/near-infrared-photothermal-therapy-using-anti-egfr-gold-nanorod-conjugates-for-triple-negative-breast-cancer
#9
Meihua Zhang, Hoe Suk Kim, Tiefeng Jin, Jisu Woo, Yin Ji Piao, Woo Kyung Moon
Current EGFR-targeted therapy for triple negative breast cancer (TNBC) has produced disappointing results. A rational therapeutic strategy to improve EGFR-targeted treatment for TNBC is therefore needed. In this study we evaluated the feasibility of treating TNBC using photoacoustic imaging (PAI)-guided near-infrared photothermal therapy (NIR-PTT) with anti-EGFR-conjugated gold nanorods (anti-EGFR-GN). NIR-PTT combined with anti-EGFR-GN exerted synergistic anti-proliferative and apoptotic actions through upregulation of HSP70 and cleaved caspase-3, downregulation of Ki-67 and EGFR, and inhibition of several intracellular signaling molecules (mTOR, AKT, ERK1/2 and FAK)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155879/subtypes-of-breast-cancer-show-different-spatial-distributions-of-brain-metastases
#10
Sunghyon Kyeong, Yoon Jin Cha, Sung Gwe Ahn, Sang Hyun Suh, Eun Ju Son, Sung Jun Ahn
The aim of our study was to test the hypothesis that the spatial distribution of breast cancer brain metastases (BM) differ according to their biological subtypes. MR images of 100 patients with BM from primary breast cancer were retrospectively reviewed. Patients were divided according to the biological subtype of the primary tumor, (triple-negative: 24, HER2 positive: 48, luminal: 28). All images marked with BMs were standardized to the human brain MRI atlas provided by the Montreal Neurological Institute 152 database...
2017: PloS One
https://www.readbyqxmd.com/read/29155240/matrix-metalloproteinases-a-challenging-paradigm-of-cancer-management
#11
REVIEW
Ali Alaseem, Khalid Alhazzani, Priya Dondapati, Saad Alobid, Anupam Bishayee, Appu Rathinavelu
Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases implicated in a variety of physiological and pathological processes. Over the decades, MMPs have been studied for their role in cancer progression, migration, and metastasis. As a result, accumulated evidence of MMPs incriminating role has made them an attractive therapeutic target. Early generations of broad-spectrum MMP inhibitors exhibited potent inhibitory activities, which subsequently led to clinical trials. Unexpectedly, these trials failed to meet the desired goals, mainly due to the lack of efficacy, poor oral bioavailability, and toxicity...
November 16, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29154532/cus-based-theranostic-micelles-for-nir-controlled-combination-chemotherapy-and-photothermal-therapy-and-photoacoustic-imaging
#12
Guojun Chen, Ben Ma, Yuyuan Wang, Ruosen Xie, Chun Li, Kefeng Dou, Shaoqin Gong
Cancer remains a major threat to human health due to low therapeutic efficacies of currently available cancer treatment options. Nanotheranostics, capable of simultaneous therapy and diagnosis/monitoring of diseases, has attracted increasing amounts of attention, particularly for cancer treatment. In this study, CuS-based theranostic micelles capable of simultaneous combination chemotherapy and photothermal therapy (PTT), as well as photoacoustic imaging, were developed for targeted cancer therapy. The micelle was formed by a CuS nanoparticle (NP) functionalized by thermosensitive amphiphilic poly(acrylamide-acrylonitrile)-poly(ethylene glycol) block copolymers...
November 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29153715/cisplatin-and-doxorubicin-high-loaded-nanodrug-based-on-biocompatible-thioether-and-ethane-bridged-hollow-mesoporous-organosilica-nanoparticles
#13
Junjie Zhang, Lixing Weng, Xiaodan Su, Guangming Lu, Wenfei Liu, Yuxia Tang, Yunlei Zhang, Jun Wen, Zhaogang Teng, Lianhui Wang
Herein, a mesoporous organosilica nanoparticle (MON) based nanodrug highly loaded with cisplatin (CDDP) and doxorubicin (DOX) (denoted as MONs/CDDP/DOX) has been successfully prepared for the first time. The MONs are characterized with core-contained double hollow shells, thioether and ethane groups separately incorporated frameworks, uniform diameter (420 nm), large surface area (592 m(2)/g), and ordered pore size (2.5 nm). The safety evaluation of the MONs based on cell viability, haemolytic activity, histological change, and serum biochemical index demonstrates that they have excellent biological compatibility...
November 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29153373/improving-digital-breast-tomosynthesis-reading-time-a-pilot-multi-reader-multi-case-study-using-concurrent-computer-aided-detection-cad
#14
Corinne Balleyguier, Julia Arfi-Rouche, Laurent Levy, Patrick R Toubiana, Franck Cohen-Scali, Alicia Y Toledano, Bruno Boyer
PURPOSE: Evaluate concurrent Computer-Aided Detection (CAD) with Digital Breast Tomosynthesis (DBT) to determine impact on radiologist performance and reading time. MATERIALS AND METHODS: The CAD system detects and extracts suspicious masses, architectural distortions and asymmetries from DBT planes that are blended into corresponding synthetic images to form CAD-enhanced synthetic images. Review of CAD-enhanced images and navigation to corresponding planes to confirm or dismiss potential lesions allows radiologists to more quickly review DBT planes...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29153365/comparison-of-screening-cedm-and-mri-for-women-at-increased-risk-for-breast-cancer-a-pilot-study
#15
Maxine S Jochelson, Katja Pinker, D David Dershaw, Mary Hughes, Girard F Gibbons, Kareem Rahbar, Mark E Robson, Debra A Mangino, Debra Goldman, Chaya S Moskowitz, Elizabeth A Morris, Janice S Sung
OBJECTIVES: Contrast enhanced digital mammography (CEDM) is a new breast imaging technology increasingly used in the diagnostic setting but its utility in the pure screening setting has not been reported. The goal of this pilot study is to prospectively compare screening CEDM to breast MRI in women with an increased risk for breast cancer. METHODS: In this IRB-approved HIPAA-compliant study, 318 women at increased breast cancer risk were consented (December 2012-May 2015) to undergo CEDM in addition to their scheduled MRI...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29152816/body-image-dissatisfaction-in-patients-undergoing-breast-reconstruction-examining-the-roles-of-breast-symmetry-and-appearance-investment
#16
Irene Teo, Gregory P Reece, Sheng-Cheng Huang, Kanika Mahajan, J Andon, Pujjal Khanal, Clement Sun, Krista Nicklaus, Fatima Merchant, Mia K Markey, Michelle Cororve Fingeret
OBJECTIVE: Reconstruction as part of treatment for breast cancer is aimed at mitigating body image concerns post-mastectomy. Although algorithms have been developed to objectively assess breast reconstruction outcomes, associations between objectively quantified breast aesthetic appearance and patient-reported body image outcomes have not been examined. Further, the role of appearance investment in explaining a patient's body image is not well understood. We investigated the extent to which objectively quantified breast symmetry and patient-reported appearance investment were associated with body image dissatisfaction in patients undergoing cancer-related breast reconstruction...
November 19, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29152563/integrated-radiomic-framework-for-breast-cancer-and-tumor-biology-using-advanced-machine-learning-and-multiparametric-mri
#17
Vishwa S Parekh, Michael A Jacobs
Radiomics deals with the high throughput extraction of quantitative textural information from radiological images that not visually perceivable by radiologists. However, the biological correlation between radiomic features and different tissues of interest has not been established. To that end, we present the radiomic feature mapping framework to generate radiomic MRI texture image representations called the radiomic feature maps (RFM) and correlate the RFMs with quantitative texture values, breast tissue biology using quantitative MRI and classify benign from malignant tumors...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29151311/how-to-manage-pseudoangiomatous-stromal-hyperplasia-our-clinical-experience
#18
Emine Kurt, Sevim Turanlı, Fatma Markoç, Uğur Berberoğlu
Background/aim: Pseudoangiomatous stromal hyperplasia (PASH) is a rare and benign mesenchymal proliferative breast lesion. Our aim is to review the clinical and radiological features of PASH and define a standard approach for its diagnosis and management. Materials and methods: Clinical records of 35 consecutive patients with PASH were retrospectively reviewed between 2009 and 2015. Patients with clinically or radiologically detected mass and patients who underwent biopsy for other indications and were diagnosed incidentally were included in the study...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29150365/correlation-between-ultrasound-appearance-of-small-breast-cancer-and-axillary-lymph-node-metastasis
#19
Xiaoqin Yu, Xiaoyan Hao, Jing Wan, Yingying Wang, Lan Yu, Binyue Liu
To study the correlation of ultrasonographic signs of small breast cancer (maximum diameter ≤2.0 cm) with axillary lymph node metastasis, pre-operative ultrasonographic images of 153 small breast malignant neoplasms in 143 breast cancer patients were analyzed according to their pathologic features. Of the small breast tumors included, 47 showed axillary lymph node metastasis. Diagnosis of all patients was obtained with radical axillary surgery or a sentinel lymph node biopsy procedure. Ultrasonographic signs included irregular shape, microlobulated contour, spiculation, microcalcification, posterior echo attenuation, blood-flow grade, perforating vessels, changes in fascia or cooper's ligament and maximum cortical thickness of lymph nodes...
November 14, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29148694/ambient-aqueous-synthesis-of-ultrasmall-ni0-85se-nanoparticles-for-non-invasive-photoacoustic-imaging-and-combined-photothermal-chemo-therapy-of-cancer
#20
Xianwen Wang, Fei Li, Xu Yan, Yan Ma, Zhaohua Miao, Liang Dong, Huajian Chen, Yang Lu, Zhengbao Zha
Big size induced long-term retention in the body has hampered the translational applications of many reported nanomedicine. Herein, we reported a multifunctional theranostic agent composed of ultrasmall polyacrylic acid functionalized Ni0.85Se nanoparticles (PAA-Ni0.85Se NPs), which were successfully obtained through a facile ambient aqueous precipitation strategy. Without exhibiting any noticeable toxicity, the as-prepared PAA-Ni0.85Se NPs (average diameter of 6.40 ± 1.89 nm) showed a considerable absorption in near-infrared (NIR) region and high photothermal conversion efficiency (PTCE) of 54...
November 17, 2017: ACS Applied Materials & Interfaces
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