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https://www.readbyqxmd.com/read/28935212/the-value-of-anticoccidials-for-sustainable-global-poultry-production
#1
REVIEW
Stefanie Kadykalo, Tara Roberts, Michelle Thompson, Jeff Wilson, Marcelo Lang, Olivier Espeisse
Coccidiosis is a self-limiting disease that is universally present in poultry operations, causing extensive damage to the intestinal lining of the bird. Global economic losses from coccidiosis are estimated to be $3 billion per year. In-feed anticoccidial use has been the predominant form of coccidiosis control. However, due to widespread emergence of antimicrobial resistance, concerns have been raised regarding the safety of anticoccidials and potential impact on human, animal, and environmental health. To investigate the alternatives, risks, and benefits to anticoccidial use, a comprehensive review of recent literature was conducted...
September 18, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28929197/venous-invasion-by-hepatic-tumors-imaging-appearance-and-implications-for-management
#2
REVIEW
Scott M Thompson, Michael L Wells, James C Andrews, Eric C Ehman, Christine O Menias, Christopher L Hallemeier, Lewis R Roberts, Sudhakar K Venkatesh
Venous invasion by hepatic tumors most commonly occurs with hepatocellular carcinoma and is associated with worse patient prognosis. Imaging plays an important role in the diagnosis of tumor thrombus in the liver. Moreover, differentiating between bland and tumor thrombus in the liver has important diagnostic, staging, therapeutic, and prognostic implications and may require a multimodal imaging approach including ultrasound, computed tomography, and/or magnetic resonance imaging. Treatment of hepatic malignancies with associated tumor thrombus is dependent on tumor type, disease extent within the liver, liver hemodynamics, and underlying liver function...
September 19, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28920890/exercise-in-patients-with-multiple-sclerosis
#3
REVIEW
Robert W Motl, Brian M Sandroff, Gert Kwakkel, Ulrik Dalgas, Anthony Feinstein, Christoph Heesen, Peter Feys, Alan J Thompson
Exercise can be a beneficial rehabilitation strategy for people with multiple sclerosis to manage symptoms, restore function, optimise quality of life, promote wellness, and boost participation in activities of daily living. However, this population typically engages in low levels of health-promoting physical activity compared with adults from the general population, a fact which has not changed in the past 25 years despite growing evidence of the benefits of exercise. To overcome this challenge, the main limitations to promoting exercise through the patient-clinician interaction must be addressed...
October 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28919801/transforming-growth-factor-%C3%AE-1-smad3-independent-epithelial-mesenchymal-transition-in-type-i-collagen-glomerulopathy
#4
Amanda C Brodeur, Anna M Roberts-Pilgrim, Kimberlee L Thompson, Craig L Franklin, Charlotte L Phillips
The glomerulofibrotic Col1a2-deficient mouse model demonstrates glomerular homotrimeric type I collagen deposition in mesangial and subendothelial spaces. In this report, we investigate the role of transforming growth factor β1 (TGF-β1) in myofibroblast activation and epithelial-mesenchymal transition (EMT) in this glomerulopathy. Immunohistochemical analyses of glomerular α-sma, desmin, vimentin, and proliferating cell nuclear antigen demonstrated parietal epithelial cell proliferation and EMT in late stages of the glomerulopathy in the Col1a2-deficient mice...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28919267/post-carotid-endarterectomy-hypertension-part-2-association-with-peri-operative-clinical-anaesthetic-and-transcranial-doppler-derived-parameters
#5
Jeremy E Newman, Mathew J Bown, Robert D Sayers, Jonathan P Thompson, Thompson G Robinson, Bryan Williams, Ronney Panerai, Peter Lacy, A Ross Naylor
OBJECTIVE/BACKGROUND: The first paper in this series observed that pre-operative baroreceptor dysfunction and poorly controlled hypertension were independently predictive for identifying patients who went on to require treatment for post-endarterectomy hypertension (PEH). The second paper examines the influence of intra-operative patient, transcranial Doppler (TCD) ultrasound, and anaesthetic variables on the incidence of PEH. METHODS: In total, 106 patients underwent carotid endarterectomy (CEA) under general anaesthesia...
September 14, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28913657/radical-cystectomy-for-recurrent-urothelial-carcinoma-after-prior-partial-cystectomy-perioperative-and-oncologic-outcomes
#6
Ross J Mason, Igor Frank, Bimal Bhindi, Matthew K Tollefson, R Houston Thompson, R Jeffrey Karnes, Robert Tarrell, Prabin Thapa, Stephen A Boorjian
PURPOSE: To evaluate perioperative and oncologic outcomes of patients undergoing radical cystectomy (RC) for recurrence of urothelial carcinoma (UC) after prior partial cystectomy (PC), and to compare these outcomes to patients undergoing primary RC. METHODS: Patients who underwent RC for recurrence of UC after prior PC were matched 1:3 to patients undergoing primary RC based on age, pathologic stage, and decade of surgery. Perioperative and oncologic outcomes were compared using Wilcoxon sign-rank test, McNemars test, the Kaplan-Meier method, and Cox proportional hazards regression analyses...
September 14, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28910237/effects-of-once-weekly-exenatide-on-cardiovascular-outcomes-in-type-2-diabetes
#7
Rury R Holman, M Angelyn Bethel, Robert J Mentz, Vivian P Thompson, Yuliya Lokhnygina, John B Buse, Juliana C Chan, Jasmine Choi, Stephanie M Gustavson, Nayyar Iqbal, Aldo P Maggioni, Steven P Marso, Peter Öhman, Neha J Pagidipati, Neil Poulter, Ambady Ramachandran, Bernard Zinman, Adrian F Hernandez
Background The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. Methods We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke...
September 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28891399/response-of-human-fetal-liver-progenitor-cell-types-to-temperature-and-ph-stresses-in-vitro
#8
Eva Schmelzer, Hubert G Foka, Robert L Thompson, Angelo Luca, Bruno Gridelli, Jörg C Gerlach
Prolonged physiological stresses including abnormal pH and temperature are deleterious. Yet, human hepatic progenitors have been shown to be quite tolerant of temporary temperature stress such as in cold ischemia. We aimed to identify how various stresses affect liver progenitors, and to determine whether distinct effects exist on different progenitor cells of the human liver. Total fetal liver cells were exposed to low (25°C), normal (37°C), or high (40°C) temperatures, or low (6.76), normal (7.35), or high (7...
September 11, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28882909/effect-of-time-and-day-of-admission-on-hospital-care-quality-for-patients-with-chronic-obstructive-pulmonary-disease-exacerbation-in-england-and-wales-single-cohort-study
#9
Christopher Michael Roberts, Derek Lowe, Emma Skipper, Michael C Steiner, Rupert Jones, Colin Gelder, John R Hurst, Gillian E Lowrey, Catherine Thompson, Robert A Stone
OBJECTIVE: To evaluate if observed increased weekend mortality was associated with poorer quality of care for patients admitted to hospital with chronic obstructive pulmonary disease (COPD) exacerbation. DESIGN: Prospective case ascertainment cohort study. SETTING: 199 acute hospitals in England and Wales, UK. PARTICIPANTS: Consecutive COPD admissions, excluding subsequent readmissions, from 1 February to 30 April 2014 of whom 13 414 cases were entered into the study...
September 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28865287/do-silhouettes-and-photographs-produce-fundamentally-different-object-based-correspondence-effects
#10
Robert W Proctor, Mei-Ching Lien, Lane Thompson
When participants classify pictures of objects as upright or inverted with a left or right keypress, responses are faster if the response location (left/right) corresponds with the location of a handle (left/right) than if it does not. This result has typically been attributed to a grasping affordance (automatic activation of muscles associated with grasping the object with the ipsilateral hand), but several findings have indicated instead that the effect is a spatial correspondence effect, much like the Simon effect for object location...
December 2017: Cognition
https://www.readbyqxmd.com/read/28864240/global-motion-perception-is-associated-with-motor-function-in-2-year-old-children
#11
Benjamin Thompson, Christopher J D McKinlay, Arijit Chakraborty, Nicola S Anstice, Robert J Jacobs, Nabin Paudel, Tzu-Ying Yu, Judith M Ansell, Trecia A Wouldes, Jane E Harding
The dorsal visual processing stream that includes V1, motion sensitive area V5 and the posterior parietal lobe, supports visually guided motor function. Two recent studies have reported associations between global motion perception, a behavioural measure of processing in V5, and motor function in pre-school and school aged children. This indicates a relationship between visual and motor development and also supports the use of global motion perception to assess overall dorsal stream function in studies of human neurodevelopment...
August 31, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28862926/alirocumab-treatment-and-achievement-of-non-high-density-lipoprotein-cholesterol-and-apolipoprotein-b-goals-in-patients-with-hypercholesterolemia-pooled-results-from-10-phase-3-odyssey-trials
#12
Harold E Bays, Lawrence A Leiter, Helen M Colhoun, Desmond Thompson, Laurence Bessac, Robert Pordy, Peter P Toth
BACKGROUND: Non-high-density lipoprotein cholesterol (non-HDL-C) and apolipoprotein (apo) B are better predictors of atherosclerotic cardiovascular disease risk than low-density lipoprotein cholesterol alone. US and European lipid management guidelines support non-HDL-C and apoB as targets for lipid-lowering therapy. METHODS AND RESULTS: This analysis evaluated the efficacy of alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, on non-HDL-C and apoB...
August 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28859793/optimizing-cholesterol-treatment-in-patients-with-muscle-complaints
#13
REVIEW
Robert S Rosenson, Steven Baker, Maciej Banach, Kenneth M Borow, Lynne T Braun, Eric Bruckert, Liam R Brunham, Alberico L Catapano, Marshall B Elam, G B John Mancini, Patrick M Moriarty, Pamela B Morris, Paul Muntner, Kausik K Ray, Erik S Stroes, Beth A Taylor, Valerie H Taylor, Gerald F Watts, Paul D Thompson
Statins are highly effective for preventing cardiovascular events by reducing low-density lipoprotein cholesterol (LDL-C). However, many patients taking statins report muscle-related symptoms that prevent the use of guideline recommended doses. Patients with reported intolerance to statins have a high risk of cardiovascular events. Clinical strategies that optimize cardiovascular risk reduction through LDL-C lowering need to be applied in patients experiencing intolerable side effects that they attribute to statins...
September 5, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28845738/numerical-versus-narrative-a-comparison-between-methods-to-measure-medical-student-performance-during-clinical-clerkships
#14
Josef Bartels, Christopher John Mooney, Robert Thompson Stone
BACKGROUND: Medical school evaluations typically rely on both language-based narrative descriptions and psychometrically converted numeric scores to convey performance to the grading committee. We evaluated inter-rater reliability and correlation of numeric versus narrative evaluations for students on their Neurology Clerkship. DESIGN/METHODS: 50 Neurology Clerkship in-training evaluation reports completed by their residents and faculty members at the University of Rochester School of Medicine were dissected into narrative and numeric components...
August 28, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28843844/cognitive-decline-in-huntington-s-disease-expansion-gene-carriers
#15
Verena Baake, Robert H A M Reijntjes, Eve M Dumas, Jennifer C Thompson, Raymund A C Roos
BACKGROUND: In Huntington's Disease (HD) cognitive decline can occur before unequivocal motor signs become apparent. As cognitive decline often starts early in the course of the disease and has a progressive nature over time, cognition can be regarded as a key target for symptomatic treatment. The specific progressive profile of cognitive decline over time is unknown. OBJECTIVE: The aim of this study is to quantify the progression of cognitive decline across all HD stages, from pre-motormanifest to advanced HD, and to investigate if CAG length mediates cognitive decline...
August 3, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28842533/genomic-analysis-of-the-dna-replication-timing-program-during-mitotic-s-phase-in-maize-zea-mays-l-root-tips
#16
Emily Elizabeth Wear, Jawon Song, Greg Zynda, Chantal LeBlanc, Tae-Jin Lee, Leigh Mickelson-Young, Lorenzo Concia, Patrick Mulvaney, Eric S Szymanski, George C Allen, Robert Martienssen, Matthew W Vaughn, Linda Hanley-Bowdoin, William Thompson
All plants and animals must replicate their DNA, using a regulated process to ensure that their genomes are completely and accurately replicated. DNA replication timing programs have been extensively studied in yeast and animal systems, but much less is known about the replication programs of plants. We report a novel adaptation of the "Repli-seq" assay for use in intact root tips of maize (Zea mays) that include several different cell lineages, and present replication profiles from cells in early, mid, and late S phase of the mitotic cell cycle...
August 25, 2017: Plant Cell
https://www.readbyqxmd.com/read/28841632/delirium-and-catatonia-in-critically-ill-patients-the-delirium-and-catatonia-prospective-cohort-investigation
#17
Jo E Wilson, Richard Carlson, Maria C Duggan, Pratik Pandharipande, Timothy D Girard, Li Wang, Jennifer L Thompson, Rameela Chandrasekhar, Andrew Francis, Stephen E Nicolson, Robert S Dittus, Stephan Heckers, E Wesley Ely
OBJECTIVES: Catatonia, a condition characterized by motor, behavioral, and emotional changes, can occur during critical illness and appear as clinically similar to delirium, yet its management differs from delirium. Traditional criteria for medical catatonia preclude its diagnosis in delirium. Our objective in this investigation was to understand the overlap and relationship between delirium and catatonia in ICU patients and determine diagnostic thresholds for catatonia. DESIGN: Convenience cohort, nested within two ongoing randomized trials...
August 24, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28840401/rural-and-urban-differences-in-sexual-behaviors-among-adolescents-in-florida
#18
Erika L Thompson, Helen Mahony, Charlotte Noble, Wei Wang, Robert Ziemba, Markku Malmi, Sarah B Maness, Eric R Walsh-Buhi, Ellen M Daley
The national teen birth rate is higher in rural compared to urban areas. While national data suggest rural areas may present higher risk for adverse sexual health outcomes among adolescents, it is unknown whether there are differences within the state of Florida. Overall, Florida has poorer sexual health indicators for adolescents compared to national rates. The purpose of this study was to assess differences in sexual behaviors among Florida adolescents by rural-urban community location. This study includes baseline data from a randomized controlled trial conducted in Florida high schools...
August 24, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28837413/radiologic-features-of-small-pulmonary-nodules-and-lung-cancer-risk-in-the-national-lung-screening-trial-a-nested-case-control-study
#19
Ying Liu, Hua Wang, Qian Li, Melissa J McGettigan, Yoganand Balagurunathan, Alberto L Garcia, Zachary J Thompson, John J Heine, Zhaoxiang Ye, Robert J Gillies, Matthew B Schabath
Purpose To extract radiologic features from small pulmonary nodules (SPNs) that did not meet the original criteria for a positive screening test and identify features associated with lung cancer risk by using data and images from the National Lung Screening Trial (NLST). Materials and Methods Radiologic features in SPNs in baseline low-dose computed tomography (CT) screening studies that did not meet NLST criteria to be considered a positive screening examination were extracted. SPNs were identified for 73 incident case patients who were given a diagnosis of lung cancer at either the first or second follow-up screening study and for 157 control subjects who had undergone three consecutive negative screening studies...
August 24, 2017: Radiology
https://www.readbyqxmd.com/read/28837178/tyrosine-sulfation-modulates-activity-of-tick-derived-thrombin-inhibitors
#20
Robert E Thompson, Xuyu Liu, Jorge Ripoll-Rozada, Noelia Alonso-García, Benjamin L Parker, Pedro José Barbosa Pereira, Richard J Payne
Madanin-1 and chimadanin are two small cysteine-free thrombin inhibitors that facilitate blood feeding in the tick Haemaphysalis longicornis. Here, we report a post-translational modification-tyrosine sulfation-of these two proteins that is critical for potent anti-thrombotic and anticoagulant activity. Inhibitors produced in baculovirus-infected insect cells displayed heterogeneous sulfation of two tyrosine residues within each of the proteins. One-pot ligation-desulfurization chemistry enabled access to homogeneous samples of all possible sulfated variants of the proteins...
September 2017: Nature Chemistry
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