keyword
https://read.qxmd.com/read/38536896/exploring-the-temporal-dynamics-of-methane-ebullition-in-a-subtropical-freshwater-reservoir
#1
JOURNAL ARTICLE
Lediane Marcon, Tobias Bleninger, Michael Männich, Mayra Ishikawa, Stephan Hilgert, Andreas Lorke
The transport of methane from sediments to the atmosphere by rising gas bubbles (ebullition) can be the dominant, yet highly variable emission pathway from shallow aquatic ecosystems. Ebullition fluxes have been reported to vary in space and time, as methane production, accumulation, and bubble release from the sediment matrix is affected by several physical and bio-geochemical processes acting at different timescales. Time-series analysis and empirical models have been used for investigating the temporal dynamics of ebullition and its controls...
2024: PloS One
https://read.qxmd.com/read/38536872/membrane-contact-sites-regulate-vacuolar-fission-via-sphingolipid-metabolism
#2
JOURNAL ARTICLE
Kazuki Hanaoka, Kensuke Nishikawa, Atsuko Ikeda, Philipp Schlarmann, Saku Sasaki, Sotaro Fujii, Sayumi Yamashita, Aya Nakaji, Kouichi Funato
Membrane contact sites (MCSs) are junctures that perform important roles including coordinating lipid metabolism. Previous studies have indicated that vacuolar fission/fusion processes are coupled with modifications in the membrane lipid composition. However, it has been still unclear whether MCS-mediated lipid metabolism controls the vacuolar morphology. Here, we report that deletion of tricalbins (Tcb1, Tcb2, and Tcb3), tethering proteins at endoplasmic reticulum (ER)-plasma membrane (PM) and ER-Golgi contact sites, alters fusion/fission dynamics and causes vacuolar fragmentation in the yeast Saccharomyces cerevisiae ...
March 27, 2024: ELife
https://read.qxmd.com/read/38536776/electroacupuncture-stimulation-enhances-the-permeability-of-the-blood-brain-barrier-a-systematic-review-and-meta-analysis-of-preclinical-evidence-and-possible-mechanisms
#3
JOURNAL ARTICLE
Nuo Xu, Peng Gong, Shiting Xu, Yangyun Chen, Mengyuan Dai, Zhaoxing Jia, Xianming Lin
An important cellular barrier to maintain the stability of the brain's internal and external environment is the blood-brain barrier (BBB). It also prevents harmful substances from entering brain tissue through blood circulation while providing protection for the central nervous system. It should be noted, however, that the intact BBB can be a barrier to the transport of most drugs into the brain via the conventional route of administration, which can prevent them from reaching effective concentrations for the treatment of disorders affecting the central nervous system...
2024: PloS One
https://read.qxmd.com/read/38536774/the-impact-of-climate-change-on-the-agriculture-and-the-economy-of-southern-gaul-new-perspectives-of-agent-based-modelling
#4
JOURNAL ARTICLE
Nicolas Bernigaud, Alberte Bondeau, Joël Guiot, Frédérique Bertoncello, Marie-Jeanne Ouriachi, Laurent Bouby, Philippe Leveau, Loup Bernard, Delphine Isoardi
What impact did the Roman Climate Optimum (RCO) and the Late Antique Little Ice Age (LALIA) have on the rise and fall of the Roman Empire? Our article presents an agent-based modelling (ABM) approach developed to evaluate the impact of climate change on the profitability of vineyards, olive groves, and grain farms in Southern Gaul, which were the main source of wealth in the roman period. This ABM simulates an agroecosystem model which processes potential agricultural yield values from paleoclimatic data. The model calculates the revenues made by agricultural exploitations from the sale of crops whose annual volumes vary according to climate and market prices...
2024: PloS One
https://read.qxmd.com/read/38535861/analysis-of-trypanosoma-equiperdum-recombinant-proteins-for-the-serological-diagnosis-of-dourine
#5
JOURNAL ARTICLE
Mirella Luciani, Gisella Armillotta, Tiziana Di Febo, Ivanka Krasteva, Simonetta Ulisse, Chiara Di Pancrazio, Caterina Laguardia, Fabrizia Perletta, Anna Serroni, Marta Maggetti, Lilia Testa, Flavio Sacchini, Mariangela Iorio, Diamante Rodomonti, Manuela Tittarelli, Maria Teresa Mercante
The significance of Trypanosoma equiperdum as the causative agent of dourine cannot be understated, especially given its high mortality rate among equids. International movement of equids should be subject to thorough health checks and screenings to ensure that animals are not infected with Trypanosoma equiperdum . This involves the implementation of quarantine protocols, testing procedures, and the issuance of health certificates to certify the health status of the animals. Three proteins, the peptidyl-prolyl cis-trans isomerase (A0A1G4I8N3), the GrpE protein homolog (A0A1G4I464) and the transport protein particle (TRAPP) component, putative (A0A1G4I740) (UniProt accession numbers SCU68469...
March 13, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535847/short-road-transport-and-slaughter-stress-affects-the-expression-profile-of-serotonin-receptors-adrenocortical-and-hematochemical-responses-in-horses
#6
JOURNAL ARTICLE
Giuseppe Bruschetta, Gabriella Zanghì, Renato Paolo Giunta, Alida Maria Ferlazzo, Katiuska Satué, Angela D'Ascola, Esterina Fazio
Horse transport is considered a cause of stress in animals and is known to affect the 5-HT concentrations in both the brain and other tissues. The aim of this research was to investigate the effect of horse transportation and slaughter stress on plasma serotonin's concentration and the expression levels of the related 5-HT1B and 5-HT2A receptors in PBMCs. Furthermore, the IL-12 levels and a variety of blood parameters, including triglycerides, total cholesterol, glucose, aspartate aminotransferase, creatine phosphokinase, lactate dehydrogenase, were also considered...
March 3, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535215/just-around-the-corner-advances-in-the-optimization-of-yeasts-and-filamentous-fungi-for-lactic-acid-production
#7
REVIEW
Nadielle Tamires Moreira Melo, Ana Caroline de Oliveira Junqueira, Letícia Ferreira Lima, Kamila Botelho Sampaio de Oliveira, Micaela Cristiane Gomes Dos Reis, Octávio Luiz Franco, Hugo Costa Paes
Lactic acid (LA) production has seen significant progress over the past ten years. LA has seen increased economic importance due to its broadening use in different sectors such as the food, medicine, polymer, cosmetic, and pharmaceutical industries. LA production bioprocesses using microorganisms are economically viable compared to chemical synthesis and can benefit from metabolic engineering for improved productivity, purity, and yield. Strategies to optimize LA productivity in microorganisms on the strain improvement end include modifying metabolic routes, adding gene coding for lactate transporters, inducing tolerance to organic acids, and choosing cheaper carbon sources as fuel...
March 9, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535119/adme-gene-related-pharmacogenomic-labeling-of-fda-approved-drugs-comparison-with-clinical-pharmacogenetics-implementation-consortium-cpic-evidence-levels
#8
JOURNAL ARTICLE
Subrata Deb, Robert Hopefl, Anthony Allen Reeves, Dena Cvetkovic
Pharmacogenomics (PGx) can facilitate the transition to patient-specific drug regimens and thus improve their efficacy and reduce toxicity. The aim of this study was to evaluate the overlap of PGx classification for drug absorption, distribution, metabolism, and elimination (ADME)-related genes in the U.S. Food and Drug Administration (FDA) PGx labeling and in the Clinical Pharmacogenetics Implementation Consortium (CPIC) database. FDA-approved drugs and PGx labeling for ADME genes were identified in the CPIC database...
February 20, 2024: Medicines (Basel, Switzerland)
https://read.qxmd.com/read/38534987/targeting-solute-carrier-transporters-slcs-as-a-therapeutic-target-in-different-cancers
#9
REVIEW
Ravi Bharadwaj, Swati Jaiswal, Erandi E Velarde de la Cruz, Ritesh P Thakare
Solute carrier (SLC) transporters constitute a vast superfamily of transmembrane proteins tasked with regulating the transport of various substances such as metabolites, nutrients, ions, and drugs across cellular membranes. SLC transporters exhibit coordinated expression patterns across normal tissues, suggesting a tightly regulated regulatory network governing normal cellular functions. These transporters are crucial for the transport of various metabolites, including carbohydrates, proteins, lipids, and nucleic acids...
March 21, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534983/collateral-damage-in-the-placenta-during-viral-infection-in-pregnancy-a-possible-mechanism-for-vertical-transmission-and-an-adverse-pregnancy-outcome
#10
REVIEW
Victor Javier Cruz-Holguín, Luis Didier González-García, Manuel Adrián Velázquez-Cervantes, Haruki Arévalo-Romero, Luis Adrián De Jesús-González, Addy Cecilia Helguera-Repetto, Guadalupe León-Reyes, Ma Isabel Salazar, Leticia Cedillo-Barrón, Moisés León-Juárez
In mammals, the placenta is a connection between a mother and a new developing organism. This tissue has a protective function against some microorganisms, transports nutrients, and exchanges gases and excretory substances between the mother and the fetus. Placental tissue is mainly composed of chorionic villi functional units called trophoblasts (cytotrophoblasts, the syncytiotrophoblast, and extravillous trophoblasts). However, some viruses have developed mechanisms that help them invade the placenta, causing various conditions such as necrosis, poor perfusion, and membrane rupture which, in turn, can impact the development of the fetus and put the mother's health at risk...
March 20, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534580/beyond-traditional-medicine-evs-loaded-hydrogels-as-a-game-changer-in-disease-therapeutics
#11
REVIEW
Shutong Du, Xiaohu Zhou, Bo Zheng
Extracellular vesicles (EVs), especially exosomes, have shown great therapeutic potential in the treatment of diseases, as they can target cells or tissues. However, the therapeutic effect of EVs is limited due to the susceptibility of EVs to immune system clearance during transport in vivo. Hydrogels have become an ideal delivery platform for EVs due to their good biocompatibility and porous structure. This article reviews the preparation and application of EVs-loaded hydrogels as a cell-free therapy strategy in the treatment of diseases...
February 21, 2024: Gels
https://read.qxmd.com/read/38532826/neuropathology-and-epilepsy-surgery-2024-update
#12
JOURNAL ARTICLE
Ingmar Blümcke
Neuropathology-based studies in neurosurgically resected brain tissue obtained from carefully examined patients with focal epilepsies remain a treasure box for excellent insights into human neuroscience, including avenues to better understand the neurobiology of human brain organization and neuronal hyperexcitability at the cellular level including glio-neuronal interaction. It also allows to translate results from animal models in order to develop personalized treatment strategies in the near future. A nice example of this is the discovery of a new disease entity in 2017, termed mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy or MOGHE, in the frontal lobe of young children with intractable seizures...
January 2024: Free neuropathology
https://read.qxmd.com/read/38531493/developing-and-validating-clinical-prediction-models-in-hepatology-an-overview-for-clinicians
#13
REVIEW
Rickard Strandberg, Peter Jepsen, Hannes Hagström
Prediction models are everywhere in clinical medicine. We use them to assign a diagnosis or a prognosis, and there is a continuous effort to develop better prediction models. It is important to understand the fundamentals of prediction modeling, and here we describe nine steps to develop and validate a clinical prediction model with the intention of implementing it in clinical practice: Determine if there is a need for a new prediction model; define the purpose and intended use for the model; assess the quality and quantity of the data you wish to develop the model on; develop the model using sound statistical methods; generate risk predictions on the probability scale (0-100%); evaluate the performance of the model in terms of discrimination, calibration, and clinical utility; validate the model using bootstrapping to correct for the apparent optimism in performance; validate the model on external datasets to assess the generalizability and transportability of the model; and finally publish the model so that it can be implemented or validated by others...
March 24, 2024: Journal of Hepatology
https://read.qxmd.com/read/38531108/current-status-of-la-crosse-virus-in-north-america-and-potential-for-future-spread
#14
JOURNAL ARTICLE
Taylor Goldman, Davidson H Hamer
La Crosse virus (LACV) is an arthropod-borne RNA virus with substantial potential for future spread in North America. La Crosse virus is responsible for La Crosse encephalitis, a leading cause of arboviral encephalitis in children in the United States. Primarily transmitted by Aedes triseriatus (Eastern treehole) mosquitos and amplified by small mammal hosts, LACV has caused infections throughout the upper Midwest and, more recently, the mid-Atlantic and southeastern United States. Notably, in recent years, infections have also been identified increasingly in the Appalachian region...
March 26, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38530312/food-insecurity-prevalence-and-risk-factors-at-a-large-academic-medical-center-in-michigan
#15
JOURNAL ARTICLE
Cindy W Leung, Minal R Patel, Markell Miller, Eileen Spring, Zixi Wang, Julia A Wolfson, Alicia J Cohen, Michele Heisler, Wei Hao
IMPORTANCE: Health care systems are increasingly adopting methods to screen for and integrate food insecurity and other social risk factors into electronic health records. However, there remain knowledge gaps regarding the cumulative burden of food insecurity in large clinical settings, which patients are most at risk, and the extent to which patients are interested in social assistance through their health care system. OBJECTIVE: To evaluate the 5-year prevalence and associated risk factors of food insecurity among adult primary care patients, and to examine factors associated with patients' interest in social assistance among those with food insecurity...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38529769/dosimetry-during-iodine-131-therapy-a-technical-point-of-view-from-a-single-centre-s-own-experience
#16
JOURNAL ARTICLE
Wioletta Chalewska, Paulina Cegla, Anna Moczulska, Edyta Strzemecka, Agata Sackiewicz, Marek Dedecjus
BACKGROUND: Nuclear medicine uses radionuclides in medicine for diagnosis, staging, therapy, and monitoring the response to therapy. The application of radiopharmaceutical therapy for the treatment of certain diseases is well-established, and the field is expanding. Internal dosimetry is multifaceted and includes different workflows, as well as various calculations based on patient- specific dosimetry. AIM: The objective of this study was to introduce the technical issues which might occur during iodine-131 (¹³¹I) dosimetry performed in nuclear medicine departments...
2024: Nuclear Medicine Review. Central & Eastern Europe
https://read.qxmd.com/read/38529605/role-of-abca1-in-atherosclerosis-novel-mutations-and-potential-plant-derived-therapies
#17
JOURNAL ARTICLE
Siarhei A Dabravolski, Nikolay A Orekhov, Victor Y Glanz, Vasily N Sukhorukov, Elizaveta M Pleshko, Alexander N Orekhov
ATP-binding cassette transporter A1 (ABCA1) is one of the key proteins regulating cholesterol homeostasis and playing a crucial role in atherosclerosis development. ABCA1 regulates the rate-limiting step of reverse cholesterol transport, facilitates the efflux of surplus intracellular cholesterol and phospholipids, and suppresses inflammation through several signalling pathways. At the same time, many mutations and Single Nucleotide Polymorphisms (SNPs) have been identified in the ABCA1 gene, which affects its biological function and is associated with several hereditary diseases (such as familial hypo-alpha-lipoproteinaemia and Tangier disease) and increased risk of cardiovascular diseases (CVDs)...
March 25, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38529311/malaria-biochemical-physiological-diagnostic-and-therapeutic-updates
#18
JOURNAL ARTICLE
Enas El Saftawy, Mohamed F Farag, Hossam H Gebreil, Mohamed Abdelfatah, Basma Emad Aboulhoda, Mansour Alghamdi, Emad A Albadawi, Marwa Ali Abd Elkhalek
BACKGROUND: Malaria has been appraised as a significant vector-borne parasitic disease with grave morbidity and high-rate mortality. Several challenges have been confronting the efficient diagnosis and treatment of malaria. METHOD: Google Scholar, PubMed, Web of Science, and the Egyptian Knowledge Bank (EKB) were all used to gather articles. RESULTS: Diverse biochemical and physiological indices can mirror complicated malaria e.g., hypoglycemia, dyslipidemia, elevated renal and hepatic functions in addition to the lower antioxidant capacity that does not only destroy the parasite but also induces endothelial damage...
2024: PeerJ
https://read.qxmd.com/read/38529310/waterlogging-in-soil-restricts-the-growth-of-gleditsia-sinensis-seedlings-and-inhibits-the-accumulation-of-lignans-and-phenolic-acids-in-thorns
#19
JOURNAL ARTICLE
Zai-Qi Luo, Xiao-Qian Shi, Xian-Ying Wang, Qiu-Lan Yang, Xin Pan, Wen-Xia Pan, Chun-Li Luo, Shan-Shan Yu, Wen-Wen Zhou, Bin-Rui Ren, Yin Yi, Xi-Min Zhang
Gleditsia sinensis , commonly known as Chinese Zaojiao, has important economic value and medicinal compounds in its fruits and thorns, making it widely cultivated artificially in China. However, the available literature on the impact of waterlogging on the growth of G. sinensis seedlings and the accumulation of metabolite compounds in its thorns is limited. To address this knowledge gap, G. sinensis seedlings were planted in soil supplemented with pindstrup substrate, which enhances the water-holding capacity of the soil...
2024: PeerJ
https://read.qxmd.com/read/38528830/towards-maintaining-canine-training-aid-integrity-effects-of-environmental-factors-and-operational-use-on-the-triacetone-triperoxide-polymer-odor-capture-and-release-system
#20
JOURNAL ARTICLE
Emily Cropper, Paige Riley, Alison G Simon
There are many factors that may affect the longevity of or guide the use of canine training aids. Literature to date has mainly focused on identifying the headspace volatiles associated with training aids or odors and only minimal research exists into how different variables may alter those volatiles. The current study examines several factors affecting canine training aids: humidity, air flow, transportation, and operational deployment, using the triacetone triperoxide polymer odor capture-and-release canine training aid (TATP POCR) as the target...
March 26, 2024: Journal of Forensic Sciences
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