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https://www.readbyqxmd.com/read/29112095/cardiac-repair-in-a-patient-who-had-a-previous-clamshell-thoracotomy
#1
Daniel Ricaurte, Renee Aboushi, Brian Myer, Thomas M Scalea
No abstract text is available yet for this article.
November 3, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29053438/tailored-approach-to-surgical-exposure-reduces-surgical-site-complications-after-bilateral-lung-transplantation
#2
Stefan Elde, Stephen Huddleston, Scott Jackson, Rosemary Kelly, Sara Shumway, Gabriel Loor
BACKGROUND: We evaluated the effects of tailoring the operative approach on major surgical site complications and outcomes in lung transplant recipients. PATIENTS AND METHODS: Beginning in July 2013, bilateral lung transplants at a single institution were performed either through sternotomy or clamshell depending on proximity of hilar structures by computed tomography (CT), anticipated complexity, past surgical history, and surgeon experience. Patient demographics and outcomes were collected in the institution's Transplant Information Services (TIS)...
October 20, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29019687/simulated-dynamics-of-glycans-on-ligand-binding-domain-of-nmda-receptors-reveals-strong-dynamic-coupling-between-glycans-and-protein-core
#3
Anton V Sinitskiy, Vijay S Pande
N-Methyl-d-aspartate (NMDA) receptors, key neuronal receptors playing the central role in learning and memory, are heavily glycosylated in vivo. Astonishingly little is known about the structure, dynamics, and physiological relevance of glycans attached to them. We recently demonstrated that certain glycans on the ligand binding domain (LBD) of NMDA receptors (NMDARs) can serve as intramolecular potentiators, changing EC50 of NMDAR coagonists. In this work, we use molecular dynamics trajectories, in aggregate 86...
October 31, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28844590/surgical-approaches-anaesthetic-management-and-outcome-in-pediatric-superior-mediastinal-tumors
#4
Gehad Ahmed, Mohammed M Hegazy, Tarek Raafat, Hanafy Hafez, Sayed Fadel, Maged Elshafiey
BACKGROUND: Pediatric superior mediastinal tumors are a heterogeneous group of tumors with marked variation in pathology and extension. We reviewed our experience with different surgical approaches to tumors originating from or extending to superior mediastinum in pediatrics. PATIENTS AND METHODS: The medical records of all patients who had undergone resection for superior mediastinal tumors in Children's Cancer Hospital - Egypt, between January 2008 to December 2015, were reviewed for demographic data, clinico-pathological features, radiologic findings, operative techniques and outcome...
August 22, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28838515/surgical-repair-of-cervical-aortic-arch-with-brain-circulation-anomaly-through-clamshell-incision
#5
Toshihito Gomibuchi, Tatsuichiro Seto, Takateru Yamamoto, Ko Nakahara, Noburo Ohashi, Yoshinori Ohtsu, Yuko Wada, Daisuke Fukui, Kenji Okada
We report the successful surgical repair of a cervical aortic arch and diverticulum with a brain circulation anomaly through a clamshell incision. Because of the reliability of selective antegrade cerebral perfusion and superior exposure, we chose an approach through a clamshell incision. We describe the utility of this approach for treating a cervical aortic arch with a diverticulum.
September 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28761055/a-single-channel-mechanism-for-pharmacological-potentiation-of-glun1-glun2a-nmda-receptors
#6
Divyan A Chopra, Kiran Sapkota, Mark W Irvine, Guangyu Fang, David E Jane, Daniel T Monaghan, Shashank M Dravid
NMDA receptors (NMDARs) contribute to several neuropathological processes. Novel positive allosteric modulators (PAMs) of NMDARs have recently been identified but their effects on NMDAR gating remain largely unknown. To this end, we tested the effect of a newly developed molecule UBP684 on GluN1/GluN2A receptors. We found that UBP684 potentiated the whole-cell currents observed under perforated-patch conditions and slowed receptor deactivation. At the single channel level, UBP684 produced a dramatic reduction in long shut times and a robust increase in mean open time...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28749259/management-of-pododermatitis-with-an-orthotic-boot-in-a-southern-isabela-giant-tortoise-chelonoidis-vicina
#7
Lynnette Waugh, Jennifer D'Agostino, Gretchen A Cole, Alicia Hahn, Jonathan D Day
A 62-yr-old male Southern Isabela giant tortoise (Chelonoidis vicina) had a 1-yr history of chronic, reoccurring pododermatitis on the palmar surface of the left forelimb. Aggressive wound management was instituted and included surgical debridement, vacuum-assisted closure, and orthotic boot support during healing. A custom fabricated, carbon fiber clamshell Charcot Restraint Orthotic Walker walking boot was utilized to reduce focal pressure over the wound during weight bearing and promote a more normal gait...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28734456/clamshell-closure-with-absorbable-sternal-pins-in-lung-transplant-recipients
#8
Anne Olland, Jérémie Reeb, Sophie Guinard, Joseph Seitlinger, Nicola Santelmo, Romain Kessler, Pierre-Emmanuel Falcoz, Gilbert Massard
Clamshell (bilateral anterolateral thoracotomy combined to transverse sternotomy) is an invasive surgical approach that is helpful in particular situations, especially bilateral lung transplantation. The closure technique remains challenging because clamshell incision can end with override, separation, or sternal pseudarthrosis complications. We describe the use of new absorbable sternal pins to stabilize the sternal closure and to help avoid additional sternal complications.
August 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28715027/elongation-of-magnetic-relaxation-times-in-a-single-molecule-magnet-through-intermetallic-interactions-a-clamshell-type-dinuclear-terbium-iii-phthalocynaninato-quadruple-decker-complex
#9
Yoji Horii, Keiichi Katoh, Brian K Breedlove, Masahiro Yamashita
A clamshell-type terbium(iii)-phthalocyaninato quadruple-decker complex was synthesized. Magnetic measurements revealed that Tb-Tb interactions caused an increase in the magnetic relaxation time and enhanced the SMM properties.
July 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28671862/median-sternotomy-for-lung-transplantation-techniques-and-advantages
#10
Nicholas R Teman, Jianzhou T Xiao, Curtis G Tribble, Patrick E Parrino
Lung transplantation is traditionally performed with a clamshell thoracotomy or bilateral anterior thoracotomy incisions. We have performed 121 lung transplants with a median sternotomy incision from 2013-2017. We present our technique for lung transplantation utilizing cardiopulmonary bypass with a median sternotomy, and discuss the potential advantages of this technique.
June 19, 2017: Heart Surgery Forum
https://www.readbyqxmd.com/read/28651998/elephant-trunk-technique-with-a-handmade-skirted-tube-graft-how-do-we-prepare-it
#11
Gökhan Lafci, Eren Gunertem, Serpil Sahin, Garip Altintas, Mahmut Ulaş
The surgical treatment of diffuse thoracic aortic pathologies remains a challenge in aortic surgery for surgeons. Traditionally, these aortic diseases are treated with a 2-step approach known as the "elephant trunk procedure." This technique gives us an opportunity for the construction of the distal anastomosis during the initial operation. However, this staged approach is associated with a substantial overall mortality and morbidity. In order to improve the outcomes, few single-stage repair methods have been tried...
June 24, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28581551/luminescence-of-tartrate-bridged-dinuclear-2-2-bipyridine-platinum-ii-complexes-emission-color-controlled-by-intra-and-inter-molecular-interactions-in-the-solid-state
#12
Keiji Ohno, Honami Tanuma, Yukiko Kusano, Sumio Kaizaki, Akira Nagasawa, Takashi Fujihara
Novel dinuclear Pt(II) complexes with a chiral (l-) and an achiral (meso-) tartrate [{Pt(II)(bpy)}2(μ-x-tart)] (bpy: 2,2'-bipyridine; tartH2(2-): tartrate; x = l (1), meso (2)) and with a racemic (dl-) tartrate [{Pt(II)(bpy)}2(μ-d-tart)][{Pt(II)(bpy)}2(μ-l-tart)] (3) were synthesized, and the influence of their stereochemistry on their molecular and crystal structures affecting their luminescence was discussed. Effects of the dinuclearity on the structures and luminescence were revealed by comparison with those of a novel racemic mononuclear complex [Pt(II)(bpy)(d-tartH2)][Pt(II)(bpy)(l-tartH2)] (4)...
June 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28534738/optocontrol-of-glutamate-receptor-activity-by-single-side-chain-photoisomerization
#13
Viktoria Klippenstein, Christian Hoppmann, Shixin Ye, Lei Wang, Pierre Paoletti
Engineering light-sensitivity into proteins has wide ranging applications in molecular studies and neuroscience. Commonly used tethered photoswitchable ligands, however, require solvent-accessible protein labeling, face structural constrains, and are bulky. Here, we designed a set of optocontrollable NMDA receptors by directly incorporating single photoswitchable amino acids (PSAAs) providing genetic encodability, reversibility, and site tolerance. We identified several positions within the multi-domain receptor endowing robust photomodulation...
May 23, 2017: ELife
https://www.readbyqxmd.com/read/28525608/surgical-resection-for-advanced-lung-cancer-using-the-hemi-clamshell-approach
#14
Yasushi Shintani, Ryu Kanzaki, Tomohiro Kawamura, Soichiro Funaki, Masato Minami, Meinoshin Okumura, Eiji Okura, Yoshihisa Kadota, Mitsunori Ohta
OBJECTIVES: The hemi-clamshell (HCS) approach consists of partial sternotomy with antero-lateral thoracotomy. This study evaluated the utilities and outcomes of the HCS approach in advanced lung cancer patients. METHODS: We retrospectively investigated 45 patients who underwent surgery for advanced lung cancer via the HCS procedure between 2000 and 2014, the indications for surgery being tumour invasion extending to the aorta arch in 5, descending aorta in 9, main pulmonary artery in 5, superior vena cava in 6, right or left atrium in 4, apical thoracic dome in 7 patients and mediastinal lymphadenopathy for left-sided lung cancer in 12...
September 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28507245/conformational-changes-of-an-interdomain-linker-mediate-mechanical-signal-transmission-in-sensor-kinase-bvgs
#15
Elodie Lesne, Elian Dupré, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson
The whooping cough agent, Bordetella pertussis, controls the expression of its large virulence regulon in a coordinated manner through the two-component system BvgAS. BvgS is a dimeric, multidomain sensor kinase. Each monomer comprises, in succession, tandem periplasmic Venus flytrap (VFT) domains, a transmembrane segment, a cytoplasmic Per-Arnt-Sim (PAS) domain, a kinase module, and additional phosphorelay domains. BvgS shifts between kinase and phosphatase modes of activity in response to chemical modulators that modify the clamshell motions of the VFT domains...
September 15, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28448049/controlled-release-of-chlorine-dioxide-in-a-perforated-packaging-system-to-extend-the-storage-life-and-improve-the-safety-of-grape-tomatoes
#16
Xiuxiu Sun, Elizabeth Baldwin, Anne Plotto, Jan Narciso, Christopher Ference, Mark Ritenour, Ken Harrison, Joseph Gangemi, Jinhe Bai
A controlled-release chlorine dioxide (ClO2) pouch was developed by sealing a slurry form of ClO2 into semipermeable polymer film; the release properties of the pouch were monitored in containers with or without fruit. The pouch was affixed to the inside of a perforated clamshell containing grape tomatoes, and the effect on microbial population, firmness, and weight loss was evaluated during a 14 day storage period at 20 °C. Within 3 days, the ClO2 concentration in the clamshells reached 3.5 ppm and remained constant until day 10...
April 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28399991/in-package-inhibition-of-e-%C3%A2-coli-o157-h7-on-bulk-romaine-lettuce-using-cold-plasma
#17
Sea C Min, Si Hyeon Roh, Brendan A Niemira, Glenn Boyd, Joseph E Sites, Joseph Uknalis, Xuetong Fan
Dielectric barrier discharge atmospheric cold plasma (DACP) treatment was evaluated for the inactivation of Escherichia coli O157:H7, surface morphology, color, carbon dioxide generation, and weight loss of bulk Romaine lettuce in a commercial plastic clamshell container. The lettuce samples were packed in a model bulk packaging configuration (three rows with either 1, 3, 5, or 7 layers) in the container and treated by DACP (42.6 kV, 10 min). DACP treatment reduced the number of E. coli O157:H7 in the leaf samples in the 1-, 3-, and 5-layer configurations by 0...
August 2017: Food Microbiology
https://www.readbyqxmd.com/read/28378791/computationally-discovered-potentiating-role-of-glycans-on-nmda-receptors
#18
Anton V Sinitskiy, Nathaniel H Stanley, David H Hackos, Jesse E Hanson, Benjamin D Sellers, Vijay S Pande
N-methyl-D-aspartate receptors (NMDARs) are glycoproteins in the brain central to learning and memory. The effects of glycosylation on the structure and dynamics of NMDARs are largely unknown. In this work, we use extensive molecular dynamics simulations of GluN1 and GluN2B ligand binding domains (LBDs) of NMDARs to investigate these effects. Our simulations predict that intra-domain interactions involving the glycan attached to residue GluN1-N440 stabilize closed-clamshell conformations of the GluN1 LBD. The glycan on GluN2B-N688 shows a similar, though weaker, effect...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28329118/comparison-of-surgical-approach-and-extent-of-resection-for-masaoka-koga-stage-i-and-ii-thymic-tumours-in-europe-north-america-and-asia-an-international-thymic-malignancy-interest-group-retrospective-database-analysis
#19
Wentao Fang, Xiaopan Yao, Alberto Antonicelli, Zhitao Gu, Frank Detterbeck, Eric Vallières, Ralph W Aye, Alexander S Farivar, James Huang, Yue Shang, Brian E Louie
OBJECTIVES: Surgeons at different institutions worldwide choose different types of operations for thymic tumours. It is not known whether these differences affect the outcomes of the patients. METHODS: A total of 1430 patients with Masaoka-Koga pathological Stage I-II thymic tumours without myasthenia gravis or pre-treatment were identified from the International Thymic Malignancy Interest Group retrospective database. Outcomes of patients from 3 major continents (Europe, North America and Asia) were compared...
July 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28289744/adsorption-of-the-natural-protein-surfactant-rsn-2-onto-liquid-interfaces
#20
Giovanni B Brandani, Steven J Vance, Marieke Schor, Alan Cooper, Malcolm W Kennedy, Brian O Smith, Cait E MacPhee, David L Cheung
To stabilize foams, droplets and films at liquid interfaces a range of protein biosurfactants have evolved in nature. Compared to synthetic surfactants, these combine surface activity with biocompatibility and low solution aggregation. One recently studied example is Rsn-2, a component of the foam nest of the frog Engystomops pustulosus, which has been predicted to undergo a clamshell-like opening transition at the air-water interface. Using atomistic molecular dynamics simulations and surface tension measurements we study the adsorption of Rsn-2 onto air-water and cyclohexane-water interfaces...
March 14, 2017: Physical Chemistry Chemical Physics: PCCP
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