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https://www.readbyqxmd.com/read/27831563/tissue-type-plasminogen-activator-controls-neuronal-death-by-raising-surface-dynamics-of-extrasynaptic-nmda-receptors
#1
Flavie Lesept, Arnaud Chevilley, Julie Jezequel, Laurent Ladépêche, Richard Macrez, Margaux Aimable, Sophie Lenoir, Thomas Bertrand, Laëtitia Rubrecht, Pascale Galea, Laurent Lebouvier, Karl-Uwe Petersen, Yannick Hommet, Eric Maubert, Carine Ali, Laurent Groc, Denis Vivien
N-methyl-d-aspartate receptors (NMDARs) are ion channels whose synaptic versus extrasynaptic localization critically influences their functions. This distribution of NMDARs is highly dependent on their lateral diffusion at the cell membrane. Each obligatory subunit of NMDARs (GluN1 and GluN2) contains two extracellular clamshell-like domains with an agonist-binding domain and a distal N-terminal domain (NTD). To date, the roles and dynamics of the NTD of the GluN1 subunit in NMDAR allosteric signaling remain poorly understood...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27825685/pericardiectomy-after-previous-bypass-grafting-analyzing-risk-and-effectiveness-in-this-rare-clinical-entity
#2
Erin A Gillaspie, Joseph A Dearani, Richard C Daly, Kevin L Greason, Lyle D Joyce, Jae Oh, Hartzell V Schaff, John M Stulak
BACKGROUND: Historically the most common causes of pericarditis necessitating pericardiectomy are infection, radiation, idiopathic causes, and inflammation. More recently, there has been a rise in iatrogenic pericardial constriction, with most cases occurring after coronary artery bypass grafting (CABG). To date, there has been no large series evaluating the incidence, presentation, and effectiveness of surgical intervention. We review our 20-year experience managing this special subset of patients...
November 5, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27807495/giant-mediastinal-germ-cell-tumour-an-enigma-of-surgical-consideration
#3
Firdaus Hayati, Nurayub Mohd Ali, Levin Kesu Belani, Nornazirah Azizan, Andee Dzulkarnaen Zakaria, Mohd Ramzisham Abdul Rahman
We present a case of 16-year-old male, who was referred from private centre for dyspnoea, fatigue, and orthopnea. The chest radiograph revealed complete opacification of left chest which was confirmed by computed tomography as a large left mediastinal mass measuring 14 × 15 × 18 cm. The diagnostic needle core biopsy revealed mixed germ cell tumour with possible combination of embryonal carcinoma, yolk sac, and teratoma. After 4 cycles of neoadjuvant BEP regime, there was initial response of tumour markers but not tumour bulk...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27641097/surgical-removal-of-an-unusual-massive-mediastinal-tumour-preceded-by-interventional-embolisation
#4
Claudia Villanueva, Mathew Doyle, Jessica Berger, Gary Fermanis, Derek Glenn
Massive mediastinal tumours are rare in clinical practice and complete surgical resection may be associated with serious complications. Preoperative angiography and embolisation are valuable adjuncts in the management of giant tumours to decrease perioperative blood loss, provide a clear operative field and facilitate complete resection. We report the safe use of preoperative embolisation which facilitated excision via clamshell incision, of a highly vascular massive anterior mediastinal tumour with an unusual final diagnosis...
August 30, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27368053/architecture-of-fully-occupied-glua2-ampa-receptor-tarp-complex-elucidated-by-cryo-em
#5
Yan Zhao, Shanshuang Chen, Craig Yoshioka, Isabelle Baconguis, Eric Gouaux
Fast excitatory neurotransmission in the mammalian central nervous system is largely carried out by AMPA-sensitive ionotropic glutamate receptors. Localized within the postsynaptic density of glutamatergic spines, AMPA receptors are composed of heterotetrameric receptor assemblies associated with auxiliary subunits, the most common of which are transmembrane AMPA receptor regulatory proteins (TARPs). The association of TARPs with AMPA receptors modulates receptor trafficking and the kinetics of receptor gating and pharmacology...
August 4, 2016: Nature
https://www.readbyqxmd.com/read/27367976/immature-mediastinal-teratoma-with-unusual-histopathology-a-case-report-of-multi-lineage-somatic-type-malignant-transformation-and-a-review-of-the-literature
#6
Osama M Mustafa, Shamayel F Mohammed, Ali Aljubran, Waleed N Saleh
Germ cell tumors (GCTs) represent a well-recognized group of heterogeneous neoplasms with diverse clinical, histopathological, diagnostic, and prognostic characteristics. We present a rare case of a locally aggressive, chemotherapy-resistant immature mediastinal teratoma with a peculiar histological finding of a multilineage somatic-type malignant degeneration. A 21-year-old male patient presented with a 3-week history of persistent, blood-tinged productive cough and shortness of breath. A contrast-enhanced computed tomography (CT) scan of the chest showed a heterogeneous mass occupying the right hemithorax and abutting on adjacent structures...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27269803/lower-limb-muscle-activation-patterns-during-off-axis-elliptical-compared-with-conventional-gluteal-muscle-strengthening-exercises
#7
Cindy Y Lin, Liang-Ching Tsai, Joel Press, Yupeng Ren, Sun G Chung, Li-Qun Zhang
CONTEXT: Gluteal-muscle strength has been identified as an important component of injury prevention and rehabilitation in several common knee injuries. However, many conventionally prescribed gluteal-strengthening exercises are not performed during dynamic weight-bearing activities, which is when most injuries occur. OBJECTIVES: To compare lower-limb muscle-activation patterns between conventional gluteal-strengthening exercises and off-axis elliptical exercises with motorized foot-plate perturbations designed to activate gluteal muscles during dynamic exercise...
May 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27234784/prolonged-negative-pressure-wound-therapy-followed-by-split-thickness-skin-graft-placement-for-wide-dehiscence-of-clamshell-incision-after-bilateral-lung-transplantation-a-case-report
#8
H Suzuki, T Watanabe, T Okazaki, H Notsuda, H Niikawa, Y Matsuda, M Noda, A Sakurada, Y Hoshikawa, T Aizawa, T Miura, Y Okada
Clamshell incision is a standard approach for bilateral lung transplantation, providing a good operative field; however, once wide dehiscence occurs, its management is sometimes difficult because of intense immunosuppression and malnutrition of the recipient. A 22-year-old man with idiopathic pulmonary arterial hypertension underwent cadaveric bilateral lung transplantation through a clamshell incision using standard cardiopulmonary bypass. He developed wound dehiscence on postoperative day (POD) 20 that resulted in exposure of the bilateral fifth ribs and open pneumothorax...
April 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27226581/conformational-selection-and-submillisecond-dynamics-of-the-ligand-binding-domain-of-the-n-methyl-d-aspartate-receptor
#9
Drew M Dolino, Soheila Rezaei Adariani, Sana A Shaikh, Vasanthi Jayaraman, Hugo Sanabria
The N-methyl-d-aspartate (NMDA) receptors are heteromeric non-selective cation channels that require the binding of glycine and glutamate for gating. Based on crystal structures, the mechanism of partial agonism at the glycine-binding site is thought to be mediated by a shift in the conformational equilibrium between an open clamshell and a closed clamshell-like structure of the bilobed ligand-binding domain (LBD). Using single-molecule Förster resonance energy transfer (smFRET) and multiparameter fluorescence detection, which allows us to study the conformational states and dynamics in the submillisecond time scale, we show that there are at least three conformational states explored by the LBD: the low FRET, medium FRET, and high FRET states...
July 29, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27210468/a-20-year-experience-with-isolated-pericardiectomy-analysis-of-indications-and-outcomes
#10
Erin A Gillaspie, John M Stulak, Richard C Daly, Kevin L Greason, Lyle D Joyce, Jae Oh, Hartzell V Schaff, Joseph A Dearani
OBJECTIVES: Outcome after pericardiectomy depends on many factors, but no large study has provided clarity on the effects of patient variables or cause of pericarditis on patient survival. We report early and late results from a 20-year experience with isolated pericardiectomy. METHODS: From January 1993 to December 2013, 938 patients underwent pericardiectomy at our institution. In order to establish a homogeneous population to analyze the impact of pericardiectomy, we excluded patients with prior chest radiation, malignancy, and concomitant valvular or coronary procedures...
August 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26933056/balance-between-coiled-coil-stability-and-dynamics-regulates-activity-of-bvgs-sensor-kinase-in-bordetella
#11
E Lesne, E-M Krammer, E Dupre, C Locht, M F Lensink, R Antoine, F Jacob-Dubuisson
UNLABELLED: The two-component system BvgAS controls the expression of the virulence regulon of Bordetella pertussis. BvgS is a prototype of bacterial sensor kinases with extracytoplasmic Venus flytrap perception domains. Following its transmembrane segment, BvgS harbors a cytoplasmic Per-Arnt-Sim (PAS) domain and then a predicted 2-helix coiled coil that precede the dimerization-histidine-phosphotransfer domain of the kinase. BvgS homologs have a similar domain organization, or they harbor only a predicted coiled coil between the transmembrane and the dimerization-histidine-phosphotransfer domains...
2016: MBio
https://www.readbyqxmd.com/read/26910426/dynamics-of-the-ligand-binding-domain-layer-during-ampa-receptor-activation
#12
Jelena Baranovic, Miriam Chebli, Hector Salazar, Anna L Carbone, Katja Faelber, Albert Y Lau, Oliver Daumke, Andrew J R Plested
Ionotropic glutamate receptors are postsynaptic tetrameric ligand-gated channels whose activity mediates fast excitatory transmission. Glutamate binding to clamshell-shaped ligand binding domains (LBDs) triggers opening of the integral ion channel, but how the four LBDs orchestrate receptor activation is unknown. Here, we present a high-resolution x-ray crystal structure displaying two tetrameric LBD arrangements fully bound to glutamate. Using a series of engineered metal ion trapping mutants, we showed that the more compact of the two assemblies corresponds to an arrangement populated during activation of full-length receptors...
February 23, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/26869662/outcomes-of-minimally-invasive-lung-transplantation-in-a-single-centre-the-routine-approach-for-the-future-or-do-we-still-need-clamshell-incision
#13
Nandor Marczin, Aron-Frederik Popov, Bartlomiej Zych, Rosalba Romano, Rudolf Kiss, Anton Sabashnikov, Simona Soresi, Fabio De Robertis, Toufan Bahrami, Mohamed Amrani, Alexander Weymann, Grainne McDermott, Heike Krueger, Martin Carby, Paras Dalal, André Ruediger Simon
OBJECTIVES: Minimally invasive lung transplantation (MILT) via bilateral anterior thoracotomies has emerged as a novel surgical strategy with potential patient benefits when compared with transverse thoracosternotomy (clamshell incision, CS). The aim of this study is to compare MILT with CS by focusing on operative characteristics, postoperative organ function and support and mid-term clinical outcomes at Harefield Hospital. METHODS: It was a retrospective observational study evaluating all bilateral sequential lung transplants between April 2010 and November 2013...
May 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/26700974/a-novel-portable-foldable-laparoscopic-trainer-for-surgical-education
#14
Xiangyu Chen, Jinhong Pan, Jingyu Chen, Heqing Huang, Juan Wang, Liqin Zou, Haitao Guo, Hong Chen, Ji Zheng
OBJECTIVES: Training in laparoscopic surgeries is difficult due to high cost and limited opportunity of commercially available laparoscopic training. Many "home-made" trainers were reported to solve this obstacle, but they were either cumbersome or high cost, or both. This study aimed to create an available and effective trainer to enable the trainees in developing laparoscopic skills anytime and anywhere. METHORDS: The laparoscopic trainer contains clamshell-like plastic plates and an electronic device with camera function, which could be supplied into a serious of laparoscopic procedures...
March 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/26692413/predicting-dredging-associated-effects-to-coral-reefs-in-apra-harbor-guam-part-1-sediment-exposure-modeling
#15
Joseph Z Gailani, Tahirih C Lackey, David B King, Duncan Bryant, Sung-Chan Kim, Deborah J Shafer
Model studies were conducted to investigate the potential coral reef sediment exposure from dredging associated with proposed development of a deepwater wharf in Apra Harbor, Guam. The Particle Tracking Model (PTM) was applied to quantify the exposure of coral reefs to material suspended by the dredging operations at two alternative sites. Key PTM features include the flexible capability of continuous multiple releases of sediment parcels, control of parcel/substrate interaction, and the ability to efficiently track vast numbers of parcels...
March 1, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/26661043/pharmacology-and-structural-analysis-of-ligand-binding-to-the-orthosteric-site-of-glutamate-like-glud2-receptors
#16
Anders S Kristensen, Kasper B Hansen, Peter Naur, Lars Olsen, Natalie L Kurtkaya, Shashank M Dravid, Trine Kvist, Feng Yi, Jacob Pøhlsgaard, Rasmus P Clausen, Michael Gajhede, Jette S Kastrup, Stephen F Traynelis
The GluD2 receptor is a fundamental component of postsynaptic sites in Purkinje neurons, and is required for normal cerebellar function. GluD2 and the closely related GluD1 are classified as members of the ionotropic glutamate receptor (iGluR) superfamily on the basis of sequence similarity, but do not bind l-glutamate. The amino acid neurotransmitter D-Ser is a GluD2 receptor ligand, and endogenous D-Ser signaling through GluD2 has recently been shown to regulate endocytosis of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type iGluRs during synaptic plasticity in the cerebellum, such as long-term depression...
February 2016: Molecular Pharmacology
https://www.readbyqxmd.com/read/26652544/modified-transverse-thoracosternotomy-and-cost-effective-reinforced-sternal-closure
#17
Joseph Costa, Joshua R Sonett, Frank D'Ovidio
The bilateral transverse thoracosternotomy clamshell incision provides excellent exposure to the mediastinal structures in double lung transplantation. The use of a modified transverse sternotomy and a figure of 8 configuration with one monofilament metal wire, along with two longitudinal wires across the sternal division, results in greater stability and equally distributed oblique tension. Our described technique was more cost effective and resulted in no incidence of dehiscence. We present our experience using a modified transverse sternotomy and reinforced sternal closure method...
December 2015: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/26611510/results-of-pulmonary-resection-sarcoma-and-germ-cell-tumors
#18
REVIEW
DuyKhanh P Ceppa
Pulmonary metastasis occurs in as many as 88% and 80% of stage IV patients with sarcoma and germ cell tumors, respectively. Pulmonary metastatectomy may be the only means of rendering a patient disease free. Sublobar resection (wedge or segmentectomy), lobectomy, and pneumonectomy achieve complete resection. Bilateral disease can be resected via staged thoracoscopy/thoracotomy, median sternotomy, or clamshell thoracotomy. Multiple resections and re-resections have resulted in improved survival. Five-year survival rates as high as 35% to 52% for sarcoma and 80% for germ cell tumor can be realized...
February 2016: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/26585692/successful-repair-of-acute-type-a-aortic-dissection-15%C3%A2-years-following-bilateral-lung-transplantation
#19
Joshua L Hermsen, Ronson Madathil, Kathleen S Berfield, Kevin Li, Jason W Smith, Michael S Mulligan
This report describes a patient treated for acute type A aortic dissection 15 years after undergoing bilateral lung transplantation by a clamshell thoracotomy.
January 2016: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/26536444/nonoperative-management-in-neurologically-intact-thoracolumbar-burst-fractures-clinical-and-radiographic-outcomes
#20
Patrick W Hitchon, Kingsley Abode-Iyamah, Nader S Dahdaleh, Christopher Shaffrey, Jennifer Noeller, Wenzhuan He, Toshio Moritani
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: The identification of factors that lead to the failure of nonoperative management in neurologically intact thoracolumbar burst fractures. SUMMARY OF BACKGROUND DATA: The treatment of thoracolumbar burst fractures (TLBF) can be controversial, particularly in the neurologically intact. Surgery for intact burst fractures has been advocated for early mobilization and a shorter hospital stay...
March 2016: Spine
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