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Alan daugherty

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https://www.readbyqxmd.com/read/28802695/scarce-resource-allocation-during-disasters-a-mixed-method-community-engagement-study
#1
Elizabeth Lee Daugherty Biddison, Howard S Gwon, Monica Schoch-Spana, Alan C Regenberg, Chrissie Juliano, Ruth R Faden, Eric S Toner
BACKGROUND: During a catastrophe, health care providers may face difficult questions regarding who will receive limited life-saving resources. The ethical principles that should guide decision-making have been considered by expert panels but have not been well explored with the public or front line clinicians. The objective of this study was to characterize the public's values regarding how scarce mechanical ventilators should be allocated during an influenza pandemic, with the ultimate goal of informing a statewide scare resource allocation framework...
August 9, 2017: Chest
https://www.readbyqxmd.com/read/28729366/recommendation-on-design-execution-and-reporting-of-animal-atherosclerosis-studies-a-scientific-statement-from-the-american-heart-association
#2
REVIEW
Alan Daugherty, Alan R Tall, Mat J A P Daemen, Erling Falk, Edward A Fisher, Guillermo García-Cardeña, Aldons J Lusis, A Phillip Owens, Michael E Rosenfeld, Renu Virmani
Animal studies are a foundation for defining mechanisms of atherosclerosis and potential targets of drugs to prevent lesion development or reverse the disease. In the current literature, it is common to see contradictions of outcomes in animal studies from different research groups, leading to the paucity of extrapolations of experimental findings into understanding the human disease. The purpose of this statement is to provide guidelines for development and execution of experimental design and interpretation in animal studies...
July 20, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28729353/recommendation-on-design-execution-and-reporting-of-animal-atherosclerosis-studies-a-scientific-statement-from-the-american-heart-association
#3
REVIEW
Alan Daugherty, Alan R Tall, Mat J A P Daemen, Erling Falk, Edward A Fisher, Guillermo García-Cardeña, Aldons J Lusis, A Phillip Owens, Michael E Rosenfeld, Renu Virmani
Animal studies are a foundation for defining mechanisms of atherosclerosis and potential targets of drugs to prevent lesion development or reverse the disease. In the current literature, it is common to see contradictions of outcomes in animal studies from different research groups, leading to the paucity of extrapolations of experimental findings into understanding the human disease. The purpose of this statement is to provide guidelines for development and execution of experimental design and interpretation in animal studies...
July 20, 2017: Circulation Research
https://www.readbyqxmd.com/read/28663257/smooth-muscle-cells-derived-from-second-heart-field-and-cardiac-neural-crest-reside-in-spatially-distinct-domains-in-the-media-of-the-ascending-aorta
#4
Hisashi Sawada, Debra L Rateri, Jessica J Moorleghen, Mark W Majesky, Alan Daugherty
OBJECTIVE: Smooth muscle cells (SMCs) of the proximal thoracic aorta are embryonically derived from the second heart field (SHF) and cardiac neural crest (CNC). However, distributions of these embryonic origins are not fully defined. The regional distribution of SMCs of different origins is speculated to cause region-specific aortopathies. Therefore, the aim of this study was to determine the distribution of SMCs of SHF and CNC origins in the proximal thoracic aorta. APPROACH AND RESULTS: Mice with repressed LacZ in the ROSA26 locus were bred to those expressing Cre controlled by either the Wnt1 or Mef2c (myocyte-specific enhancer factor 2c) promoter to trace CNC- and SHF-derived SMCs, respectively...
June 29, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28539494/aortic-aneurysms
#5
REVIEW
Hong Lu, Alan Daugherty
No abstract text is available yet for this article.
June 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28500592/a-color-segmentation-based-method-to-quantify-atherosclerotic-lesion-compositions-with-immunostaining
#6
Congqing Wu, Alan Daugherty, Hong Lu
There is an increasing recognition that atherosclerotic lesion composition, rather than size, is the determinant of acute events. Immunostaining is a commonly used method to characterize atherosclerotic lesion compositions. Here, we describe a color segmentation-based approach in HSI (hue, saturation, and intensity) color mode, which minimizes subjectivity and produces accurate and consistent quantifications of atherosclerotic lesion compositions.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28459768/macrophage-mediated-mechanisms-in-atherosclerosis-still-tangled
#7
Feiming Ye, Jian-An Wang, Alan Daugherty, Hong Lu
No abstract text is available yet for this article.
June 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28420827/relaxin-and-matrix-metalloproteinase-9-in-angiotensin-ii-induced-abdominal-aortic-aneurysms
#8
Deborah A Howatt, Maya Dajee, Xiaojie Xie, Jessica Moorleghen, Debra L Rateri, Anju Balakrishnan, Valdeci Da Cunha, Douglas G Johns, David E Gutstein, Alan Daugherty, Hong Lu
BACKGROUND: This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA).Methods and Results:Male C57BL/6 or apolipoprotein E(-/-)mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E(-/-)mice...
April 18, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28270575/truncated-trkb-t1-mediated-astrocyte-dysfunction-contributes-to-impaired-motor-function-and-neuropathic-pain-after-spinal-cord-injury
#9
Jessica J Matyas, Cliona M O'Driscoll, Laina Yu, Marina Coll-Miro, Sean Daugherty, Cynthia L Renn, Alan I Faden, Susan G Dorsey, Junfang Wu
Following spinal cord injury (SCI), astrocytes demonstrate long-lasting reactive changes, which are associated with the persistence of neuropathic pain and motor dysfunction. We previously demonstrated that upregulation of trkB.T1, a truncated isoform of the brain-derived neurotrophic factor receptor (BDNF), contributes to gliosis after SCI, but little is known about the effects of trkB.T1 on the function of astrocytes. As trkB.T1 is the sole isoform of trkB receptors expressed on astrocytes, we examined the function of trkB...
April 5, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28153877/recipients-of-the-2017-early-career-investigator-awards
#10
Alan Daugherty
No abstract text is available yet for this article.
February 2, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28119286/transforming-growth-factor-%C3%AE-in-thoracic-aortic-aneurysms-good-bad-or-irrelevant
#11
EDITORIAL
Alan Daugherty, Zheying Chen, Hisashi Sawada, Debra L Rateri, Mary B Sheppard
No abstract text is available yet for this article.
January 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27818490/corrigendum-structure-and-functions-of-angiotensinogen
#12
Hong Lu, Lisa A Cassis, Craig W Vander Kooi, Alan Daugherty
No abstract text is available yet for this article.
November 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27815372/female-mice-with-an-xy-sex-chromosome-complement-develop-severe-angiotensin-ii-induced-abdominal-aortic-aneurysms
#13
Yasir Alsiraj, Sean E Thatcher, Richard Charnigo, Kuey Chen, Eric Blalock, Alan Daugherty, Lisa A Cassis
BACKGROUND: Abdominal aortic aneurysms (AAAs) are a deadly pathology with strong sexual dimorphism. Similar to humans, female mice exhibit far lower incidences of angiotensin II-induced AAAs than males. In addition to sex hormones, the X and Y sex chromosomes, and their unique complements of genes, may contribute to sexually dimorphic AAA pathology. Here, we defined the effect of female (XX) versus male (XY) sex chromosome complement on angiotensin II-induced AAA formation and rupture in phenotypically female mice...
January 24, 2017: Circulation
https://www.readbyqxmd.com/read/27618768/insights-into-ascending-aortic-aneurysm-pathogenesis-using-in-vivo-and-ex-vivo-imaging-systems-in-angiotensin-ii-infused-mice
#14
COMMENT
Mary B Sheppard, Alan Daugherty, Hong Lu
No abstract text is available yet for this article.
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27579551/calcification-in-atherosclerotic-lesions
#15
Hong Lu, Mary Sheppard, Alan Daugherty
No abstract text is available yet for this article.
October 2016: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/27470509/hypercholesterolemia-induced-by-a-pcsk9-gain-of-function-mutation-augments-angiotensin-ii-induced-abdominal-aortic-aneurysms-in-c57bl-6-mice-brief-report
#16
COMPARATIVE STUDY
Hong Lu, Deborah A Howatt, Anju Balakrishnan, Mark J Graham, Adam E Mullick, Alan Daugherty
OBJECTIVE: Gain-of-function mutations of PCSK9 (proprotein convertase subtilisin/kexin type 9) lead to hypercholesterolemia. This study was to determine whether infection of normocholesterolemic mice with an adeno-associated viral (AAV) vector expressing a gain-of-function mutation of mouse PCSK9 increased angiotensin II (AngII)-induced abdominal aortic aneurysms. APPROACH AND RESULTS: In an initial study, male C57BL/6 mice were injected intraperitoneally with either an empty vector or PCSK9 gain-of-function mutation (D377Y)...
September 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27339496/mirs-mirs-in-the-wall-who-is-the-most%C3%A2-causative-of-them-all
#17
EDITORIAL
Mary Sheppard, Debra L Rateri, Alan Daugherty
No abstract text is available yet for this article.
June 28, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27335467/complying-with-the-national-institutes-of-health-guidelines-and-principles-for-rigor-and-reproducibility-refutations
#18
Alan Daugherty, Robert A Hegele, Nigel Mackman, Daniel J Rader, Ann Marie Schmidt, Christian Weber
No abstract text is available yet for this article.
July 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27104863/tgf-%C3%AE-neutralization-enhances-angii-induced-aortic-rupture-and-aneurysm-in-both-thoracic-and-abdominal-regions
#19
Xiaofeng Chen, Debra L Rateri, Deborah A Howatt, Anju Balakrishnan, Jessica J Moorleghen, Lisa A Cassis, Alan Daugherty
AngII and TGF-β interact in development of thoracic and abdominal aortic diseases, although there are many facets of this interaction that have not been clearly defined. The aim of the present study was to determine the effects of TGF-β neutralization on AngII induced-aortic pathologies. Male C57BL/6J mice were administered with either a rabbit or mouse TGF-β neutralizing antibody and then infused with AngII. The rabbit TGF-β antibody modestly reduced serum TGF-β concentrations, with no significant enhancements to AngII-induced aneurysm or rupture...
2016: PloS One
https://www.readbyqxmd.com/read/27084890/a-high-throughput-sequencing-test-for-diagnosing-inherited-bleeding-thrombotic-and-platelet-disorders
#20
Ilenia Simeoni, Jonathan C Stephens, Fengyuan Hu, Sri V V Deevi, Karyn Megy, Tadbir K Bariana, Claire Lentaigne, Sol Schulman, Suthesh Sivapalaratnam, Minka J A Vries, Sarah K Westbury, Daniel Greene, Sofia Papadia, Marie-Christine Alessi, Antony P Attwood, Matthias Ballmaier, Gareth Baynam, Emilse Bermejo, Marta Bertoli, Paul F Bray, Loredana Bury, Marco Cattaneo, Peter Collins, Louise C Daugherty, Rémi Favier, Deborah L French, Bruce Furie, Michael Gattens, Manuela Germeshausen, Cedric Ghevaert, Anne C Goodeve, Jose A Guerrero, Daniel J Hampshire, Daniel P Hart, Johan W M Heemskerk, Yvonne M C Henskens, Marian Hill, Nancy Hogg, Jennifer D Jolley, Walter H Kahr, Anne M Kelly, Ron Kerr, Myrto Kostadima, Shinji Kunishima, Michele P Lambert, Ri Liesner, José A López, Rutendo P Mapeta, Mary Mathias, Carolyn M Millar, Amit Nathwani, Marguerite Neerman-Arbez, Alan T Nurden, Paquita Nurden, Maha Othman, Kathelijne Peerlinck, David J Perry, Pawan Poudel, Pieter Reitsma, Matthew T Rondina, Peter A Smethurst, William Stevenson, Artur Szkotak, Salih Tuna, Christel van Geet, Deborah Whitehorn, David A Wilcox, Bin Zhang, Shoshana Revel-Vilk, Paolo Gresele, Daniel B Bellissimo, Christopher J Penkett, Michael A Laffan, Andrew D Mumford, Augusto Rendon, Keith Gomez, Kathleen Freson, Willem H Ouwehand, Ernest Turro
Inherited bleeding, thrombotic, and platelet disorders (BPDs) are diseases that affect ∼300 individuals per million births. With the exception of hemophilia and von Willebrand disease patients, a molecular analysis for patients with a BPD is often unavailable. Many specialized tests are usually required to reach a putative diagnosis and they are typically performed in a step-wise manner to control costs. This approach causes delays and a conclusive molecular diagnosis is often never reached, which can compromise treatment and impede rapid identification of affected relatives...
June 9, 2016: Blood
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