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https://www.readbyqxmd.com/read/28337457/screening-for-tuberculosis-in-health-care-workers-experience-in-an-italian-teaching-hospital
#1
Christian Napoli, Filippo Ferretti, Filippo Di Ninno, Riccardo Orioli, Alessandra Marani, Maria Giuditta Sarlo, Claudio Prestigiacomo, Assunta De Luca, Giovanni Battista Orsi
Health care workers (HCW) are particularly at risk of acquiring tuberculosis (TB), even in countries with low TB incidence. Therefore, TB screening in HCW is a useful prevention strategy in countries with both low and high TB incidence. Tuberculin skin test (TST) is widely used although it suffers of low specificity; on the contrary, the in vitro enzyme immunoassay tests (IGRA) show superior specificity and sensitivity but are more expensive. The present study reports the results of a three-year TB surveillance among HCW in a large teaching hospital in Rome, using TST (by standard Mantoux technique) and IGRA (by QuantiFERON-TB) as first- and second-level screening tests, respectively...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28328809/infectious-diseases-prevalence-vaccination-coverage-and-diagnostic-challenges-in-a-population-of-internationally-adopted-children-referred-to-a-tertiary-care-children-s-hospital-from-2009-to-2015
#2
Sara Sollai, Francesca Ghetti, Leila Bianchi, Maurizio de Martino, Luisa Galli, Elena Chiappini
Infectious diseases are common in internationally adopted children (IAC).With the objective to evaluate infectious diseases prevalence in a large cohort of IAC and to explore possible risk factors for tuberculosis (TB) and parasitic infections, clinical and laboratory data at first screening visit of all IAC (<18 years) consecutively referred to our Center in 2009 to 2015 were collected and analyzed.In total, 1612 children (median age: 5.40 years; interquartile range: 3.00-7.90) were enrolled, 123/1612 (7...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28318613/latent-tuberculosis-infection-screening-prior-to-biological-treatment-in-tunisian-patients
#3
Marwa Slouma, Ines Mahmoud, Olfa Saidane, Selma Bouden, Leila Abdelmoula
OBJECTIVES: The screening of latent tuberculosis infection (LTBI) is necessary to prevent infection in patients with chronic inflammatory disease (CID) undergoing biological treatment. We aimed to assess the efficacy of LTBI screening prior to biological treatment in Tunisia, considered as a high-incidence area of active TB disease. METHODS: We conducted a retrospective study over a period of 8 years [2007-2014] including patients with chronic inflammatory rheumatism receiving biologic agents since at least 6 months...
February 24, 2017: Thérapie
https://www.readbyqxmd.com/read/28318196/-paradoxical-reaction-to-antituberculosis-treatment-in-an-immunocompetent-girl-with-pulmonary-tuberculosis
#4
Ignacio Ruiz Del Olmo Izuzquiza, Claudia Orden Rueda, Laura Ochoa Gómez, Nuria Clavero Montañés, Enrique Berdún Chéliz, Carmelo Guerrero Laleona
Paradoxical reaction to antituberculosis treatment is rare in paediatric population. We report a 9-year-old girl with high fever and productive cough for the last three weeks. Tuberculine test and Quantiferon were positive, erythrocyte sedimentation rate was 64 mm/h, culture and polymerase chain reaction for M. tuberculosis negative, and chest X ray showed a widened right mediastinum. Tuberculosis was diagnosed, therefore treatment with standard doses of rifampicin, isoniazid, pyrazinamide and ethambutol was started...
April 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28317810/comparison-of-cost-effectiveness-between-the-quantiferon-tb-gold-in-tube-and-t-spot-tests-for-screening-health-care-workers-for-latent-tuberculosis-infection
#5
Shigeto Mukai, Katsumi Shigemura, Fukashi Yamamichi, Koichi Kitagawa, Nozomi Takami, Masashi Nomi, Soichi Arakawa, Masato Fujisawa
OBJECTIVE/BACKGROUND: There are several methods used to screen for latent tuberculosis (TB) infection (LTBI) including the QuantiFERON-TB Gold-in-Tube (QFT-GIT) and T-SPOT-TB (T-SPOT) tests. Many studies have reported the equivalence of these two methods, but it is unclear which of them is more cost effective. We investigated the age and cost issues of these tests in screening for LTBI among health-care workers. MATERIALS AND METHODS: One hundred and forty new employees during 2008-2011 in our hospital were screened using the QFT-GIT test, and 140 new employees during 2011-2014 were screened with the T-SPOT test for LTBI...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28317801/utility-of-quantiferon-tuberculosis-gold-in-tube-test-for-detecting-latent-tuberculosis-infection-among-close-household-contacts-of-confirmed-tuberculosis-patients-in-accra-ghana
#6
Gloria Ivy Mensah, Sandra Akoley Sowah, Nana Yaw Asare Yeboah, Kennedy Kwasi Addo, Dolly Jackson-Sillah
OBJECTIVE/BACKGROUND: Introduction of the interferon gamma (IFN-γ) release assays with their higher sensitivity and specificity over the traditional tuberculin skin test has improved testing for latent tuberculosis infection (LTBI). None of the IFN-γ release assays has ever been used to screen for LTBI in Ghana. This study set out to determine the utility of the QuantiFERON TB Gold-in-Tube (QFT-GIT) test for the diagnosis of LTBI among close household contacts of newly diagnosed sputum smear-positive tuberculosis (TB) patents in Accra, Ghana, and the associated risk factors for a positive QFT-GIT test...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28317629/mycobacterium-kansasii-infection-in-a-patient-receiving-biologic-therapy-not-all-reactive-interferon-gamma-release-assays-are-tuberculosis
#7
Nasir Saleem, Raya Saba, Srikanth Maddika, Mitchell Weinstein
Mycobacterium kansasii, a nontuberculous mycobacterium, can lead to lung disease similar to tuberculosis. Immunotherapeutic biologic agents predispose to infections with mycobacteria, including M kansasii. T-cell-mediated interferon gamma release assays like QuantiFERON-TB Gold Test (QFT) are widely used by clinicians for the diagnosis of infections with Mycobacterium tuberculosis; however, QFT may also show positive result with certain nontuberculous mycobacterial infections. We report a case of M kansasii pulmonary infection, with a positive QFT, in an immunocompromised patient receiving prednisone, leflunomide and tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody...
April 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28299430/alternative-quantiferon-cytokines-for-diagnosis-of-children-with-active-tuberculosis-and-hiv-co-infection-in-ghana
#8
Christian Lundtoft, Anthony Afum-Adjei Awuah, Norman Nausch, Anthony Enimil, Ertan Mayatepek, Ellis Owusu-Dabo, Marc Jacobsen
IFN-γ release assays (IGRAs) often present false-negative or indeterminate results in children with tuberculosis. HIV co-infection may contribute to decreased sensitivity of IGRAs by impairing T-cell IFN-γ expression. Measurement of alternative cytokines in QuantiFERON(®) (QFT) supernatants can circumvent the IFN-γ-dependency and may improve QFT sensitivity. We aimed to identify additional cytokines from QFT supernatants for detection of Mycobacterium tuberculosis infection in children with tuberculosis and HIV co-infection from Ghana...
March 15, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28298455/evaluation-of-quantiferon%C3%A2-tb-gold-plus-in-healthcare-workers-in-a-low-incidence-setting
#9
Hee-Won Moon, Rajiv L Gaur, Sara Shu-Hwa Tien, Mary Spangler, Madhukar Pai, Niaz Banaei
Background: Although launched in 2015, little is known about the accuracy of QuantiFERON-TB Gold-Plus (QFT-Plus) for diagnosis of latent M. tuberculosis infection (LTBI). Unlike its predecessor, QFT-Plus utilizes two antigen tubes to elicit an immune response from CD4+ and CD8+ T lymphocytes. We conducted a cross-sectional study in low-risk healthcare workers (HCWs) at a single U.S. center to compare QFT-Plus to QuantiFERON-TB Gold in-tube (QFT).Method: 989 HCWs were tested with both QFT and QFT-Plus. Risk factors for LTBI were obtained from a questionnaire...
March 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28293411/a-strange-manifestation-of-malaria-in-a-native-nigerian-boy
#10
Paola Magro, Ilaria Izzo, Barbara Saccani, Salvatore Casari, Silvio Caligaris, Lina Rachele Tomasoni, Alberto Matteelli, Annamaria Lombardi, Antonella Meini, Francesco Castelli
The protective role of Sickle Cell Trait (SCT) in malaria endemic areas has been proved, and prevalence of HbS gene in malaria endemic areas is high. Splenic infarction is a well-known complication of SCT, while the association with malaria is considered rare. A Nigerian boy was admitted to our ward after returning from his country of origin, for P. falciparum malaria. He underwent abdominal ultrasound for upper right abdominal pain, showing cholecystitis and multiple splenic lesions suggestive of abscesses...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28292277/poor-predictability-of-quantiferon-tb-assay-in-recipients-and-donors-for-tuberculosis-development-after-kidney-transplantation-in-an-intermediate-tb-burden-country
#11
Enkthuya Jambaldorj, Miyeun Han, Jong Cheol Jeong, Tai Yeon Koo, Sang Il Min, Eun Young Song, Jongwon Ha, Curie Ahn, Jaeseok Yang
BACKGROUND: Tuberculosis (TB) is a common opportunistic infection after kidney transplantation (KT). The QuantiFERON-TB-Gold In-Tube test (QFT) is widely used for assessing latent TB; however, it is currently unclear whether the pre-KT QFT of the recipient and donor can predict post-KT TB. METHODS: We retrospectively reviewed patients who received KT between January 2009 and December 2015 at Seoul National University Hospital. The QFT was performed in 458 KT recipients and 239 paired living donors, and 138 KT recipients underwent both the QFT and tuberculin skin test (TST)...
March 14, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28276801/tuberculosis-infection-and-disease-in-the-2015-cohort-of-unaccompanied-minors-seeking-asylum-in-northern-stockholm-sweden
#12
Rutger Bennet, Margareta Eriksson
BACKGROUND: Minors with a stated age <18 years unaccompanied by a responsible adult form an increasing part of refugees to Europe. They are older than other asylum-seeking children and many come from countries with a high tuberculosis (TB) incidence. During the 2015 refugee crisis, 35,369 of 162,877 refugees (22%) seeking asylum in Sweden were unaccompanied minors, which gave us the opportunity to study their burden of TB infection and disease. METHODS: Of the unaccompanied minors seeking asylum in Sweden during 2015, 2936 (8...
February 19, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28274215/comparing-interferon-gamma-release-assays-with-tuberculin-skin-test-for-identifying-latent-tuberculosis-infection-that-progresses-to-active-tuberculosis-systematic-review-and-meta-analysis
#13
Peter Auguste, Alexander Tsertsvadze, Joshua Pink, Rachel Court, Noel McCarthy, Paul Sutcliffe, Aileen Clarke
BACKGROUND: Timely and accurate identification of people with latent tuberculosis infection (LTBI) is important for controlling Mycobacterium tuberculosis (TB). There is no gold standard for diagnosis of LTBI. Screening tests such as interferon gamma release assays (IGRAs) and tuberculin skin test (TST) provide indirect and imperfect information. This systematic review compared two types of IGRAs QuantiFERON®-TB Gold In-Tube test (QFT-GIT) and T-SPOT.TB with TST for identification of LTBI by predicting progression to a diagnosis of active TB in three subgroups: children, immunocompromised people, and those recently arrived from countries with high TB burden...
March 9, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28270092/validation-of-t-track%C3%A2-cmv-to-assess-the-functionality-of-cytomegalovirus-reactive-cell-mediated-immunity-in-hemodialysis-patients
#14
Bernhard Banas, Carsten A Böger, Gerhard Lückhoff, Bernd Krüger, Sascha Barabas, Julia Batzilla, Mathias Schemmerer, Josef Köstler, Hanna Bendfeldt, Anne Rascle, Ralf Wagner, Ludwig Deml, Joachim Leicht, Bernhard K Krämer
BACKGROUND: Uncontrolled cytomegalovirus (CMV) replication in immunocompromised solid-organ transplant recipients is a clinically relevant issue and an indication of impaired CMV-specific cell-mediated immunity (CMI). Primary aim of this study was to assess the suitability of the immune monitoring tool T-Track® CMV to determine CMV-reactive CMI in a cohort of hemodialysis patients representative of patients eligible for renal transplantation. Positive and negative agreement of T-Track® CMV with CMV serology was examined in 124 hemodialysis patients, of whom 67 (54%) revealed a positive CMV serostatus...
March 7, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28264462/use-of-the-quantiferon-tb-gold-in-tube-test-in-the-diagnosis-and-monitoring-of-treatment-efficacy-in-active-pulmonary-tuberculosis
#15
Ping-Chin Chang, Pin-Hui Wang, Kow-Tong Chen
The value of QuantiFERON in the diagnosis of tuberculosis disease and in the monitoring of the response to anti-tuberculosis treatment is unclear. The aims of this study were to evaluate the accuracy of the QuantiFERON-TB Gold In-Tube (QFT-GIT) test in the diagnosis of tuberculosis and in the monitoring of the response to anti-tuberculosis treatment in patients with active pulmonary tuberculosis (PTB). Between January 2013 and December 2015, 133 cases with active PTB and 133 controls with no mycobacterial infection, matched by age (within 3 years) and by the week that they visited Tainan Chest Hospital, were enrolled in the study...
February 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28254396/new-insights-on-tuberculous-aortitis
#16
Laure Delaval, Tiphaine Goulenok, Paul Achouh, David Saadoun, Julien Gaudric, Quentin Pellenc, Jean-Emmanuel Kahn, Nicoletta Pasi, Damien van Gysel, Patrick Bruneval, Thomas Papo, Karim Sacre
OBJECTIVE: Aortitis is an exceedingly rare manifestation of tuberculosis. We describe 11 patients with tuberculous aortitis (TA). METHODS: Multicenter medical charts of patients hospitalized between 2003 and 2015 with TA in Paris, France, were reviewed. Demographic, medical history, laboratory, imaging, pathologic findings, treatment, and follow-up data were extracted from medical records. TA was considered when aortitis was diagnosed in a patient with active tuberculosis...
February 18, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28249638/comparison-of-quantiferon-tb-gold-in-tube-qft-git-and-tuberculin-skin-test-tst-for-diagnosis-of-latent-tuberculosis-in-haemodialysis-hd-patients-a-meta-analysis-of-%C3%AE%C2%BA-estimates
#17
E Ayubi, A Doosti-Irani, A Sanjari Moghaddam, S Khazaei, K Mansori, S Safiri, M Sani, E Mostafavi
Diagnosis of latent tuberculosis infection (LTBI) is a concern in haemodialysis (HD) patients. Many studies have compared QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) for detecting LTBI and reported the κ statistic of agreement between QFT-GIT and TST in HD patients. The present study aimed to systematically review this literature and conduct meta-analysis of individual studies that estimated the κ between QFT-GIT with TST among HD patients. All relevant published studies that were available as full-text were obtained by searching Medline (1950), Web of Sciences (1945), Scopus (1973) through May 2016...
March 2, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28225338/potential-biomarkers-associated-with-discrimination-between-latent-and-active-pulmonary-tuberculosis
#18
R Kamakia, S Kiazyk, J Waruk, A Meyers, J Ochanda, T B Ball, J Oyugi
SETTING: A third of the world's population has latent tuberculous infection (LTBI). Current TB diagnostics used in developing countries are ineffective and are unable to distinguish LTBI from active TB. Identifying biomarkers that could aid in the early detection of TB and in distinguishing TB states could be a major breakthrough in global TB control. OBJECTIVE: To identify potential immune biomarkers to distinguish active TB from LTBI. DESIGN: A cross-sectional study was conducted among 19 active TB patients, 8 TB-negative individuals (controls) and 16 LTBI non-human immunodeficiency virus infected individuals in Nairobi, Kenya...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28225337/multiple-cytokines-for-the-detection-of-mycobacterium-tuberculosis-infection-in-children-with-tuberculosis
#19
N Nausch, C Lundtoft, G Schulz, H Henckel, E Mayatepek, B Fleischer, F M Marx, M Jacobsen
SETTING: Interferon-gamma (IFN-γ) release assays (IGRAs) play an important role in the diagnosis of Mycobacterium tuberculosis infection. However, in children with tuberculosis (TB), some studies have shown increased frequencies of false-negative or indeterminate IGRA results. OBJECTIVE: To analyse the spectrum of different cytokines to improve the diagnostic accuracy of IGRAs in latent tuberculous infection (LTBI) and active TB. DESIGN: We performed multiplex cytokine expression analysis of QuantiFERON® Gold In-Tube supernatants in children with active TB (n = 21) and disease-free contacts with (n = 15) and without LTBI (n = 12), to determine the sensitivity and specificity of the modified tests...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28224776/clinical-usefulness-of-monitoring-cytomegalovirus-specific-immunity-by-quantiferon-cmv-in-pediatric-allogeneic-hematopoietic-stem-cell-transplantation-recipients
#20
Sae Mi Lee, Yae Jean Kim, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Eun Suk Kang
Cytomegalovirus (CMV) is a well-established cause of morbidity and mortality in pediatric recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). CD8⁺ T-cells are important for controlling CMV infection. We conducted a prospective pilot study to investigate the clinical utility of measuring the CMV-specific T-cell immune response using the QuantiFERON-CMV assay (QF-CMV) in pediatric allo-HSCT recipients. Overall, 16 of 25 (64%) patients developed CMV infection. QF-CMV was evaluated in these 16 patients during the early and late phases of the first CMV infection post allo-HSCT...
May 2017: Annals of Laboratory Medicine
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