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JOURNAL ARTICLE
Paula Rodríguez-Molino, Araceli González Sánchez, Antoni Noguera-Julián, Aleix Soler-García, Patricia Martínez Paz, Ana Méndez-Echevarría, Fernando Baquero-Artigao, Miguel González Muñoz, María Jesús Ruíz-Serrano, Manuel Monsonís, Rocío Sánchez León, Jesús Saavedra-Lozano, Begoña Santiago-García, Talía Sainz
We analyzed 136 children with tuberculosis disease or infection and a positive QuantiFERON-TB (QFT) assay, followed-up for a median of 21 months (0.4-11years). QFT reversed in 16.9% of cases, with significant decreases in TB1 (-1.72 vs . -0.03 IU/ml, p=0.001) and TB2 (-1.65 vs . -0.43 IU/ml, p=0.005) levels compared to non-reverters. We found a higher QFT reversion rate among children under 5 years (25.0% vs 11.9%, p=0.042), and those with TST induration <15mm (29% vs 13.3%, p=0.055). Our data reveal that, although QFT test remained positive in the majority of children, reversion occurred in 16% of cases in a progressive and stable pattern...
2024: Frontiers in Immunology
#2
JOURNAL ARTICLE
Esther Culebras, Mercedes Martínez, Consuelo Novella, Jose Manuel León, Esther Marcos, Alberto Delgado-Iribarren, Esther Ríos
BACKGROUND: The aim of the study was to evaluate the humoral and cellular immunity after SARS-CoV-2 infection and/or vaccination according to the type of vaccine, number of doses and combination of vaccines. METHODS: Volunteer subjects were sampled between September 2021 and July 2022 in Hospital Clínico San Carlos, Madrid (Spain). Participants had different immunological status against SARS-CoV-2: vaccinated and unvaccinated, with or without previous COVID-19 infection, including healthy and immunocompromised individuals...
2024: Frontiers in Cellular and Infection Microbiology
#3
JOURNAL ARTICLE
Paula Rodríguez-Molino, Marc Tebruegge, Antoni Noguera-Julian, Olaf Neth, Katy Fidler, Folke Brinkmann, Talia Sainz, Inga Ivaskeviciene, Nicole Ritz, Maria Joao Brito, Tiago Milheiro Silva, Vira Chechenieva, Maryna Serdiuk, Laura Lancella, Cristina Russo, Aleix Soler-García, Maria Luisa Navarro, Renate Krueger, Cornelia Feiterna-Sperling, Anna Starshinova, Antonina Hiteva, Anna Hoffmann, Paulius Kalibatas, Andrea Lo Vecchio, Sara Maria Scarano, Matilde Bustillo, Daniel Blázquez Gamero, María Espiau, Danilo Buonsenso, Lola Falcón, Louise Turnbull, Elena Colino, Santiago Rueda, Charlotte Buxbaum, Begoña Carazo, Cristina Alvarez, Marta Dapena, Anabel Piqueras, Svetlana Velizarova, Iveta Ozere, Florian Götzinger, Marta Pareja, Maria Isabel Garrote Llanos, Beatriz Soto, Sonia Rodríguez Martín, Jose Javier Korta, Beatriz Pérez-Gorricho, Mercedes Herranz, Ángel Hernández-Bartolomé, Mariana Díaz-Almirón, Malte Kohns Vasconcelos, Laura Ferreras-Antolín, Begoña Santiago-García
BACKGROUND: In high-resource settings the survival of immunocompromised (IC) children has increased and immunosuppressive therapies are increasingly being used. This study aimed to determine the clinical characteristics, performance of diagnostic tools and outcome of IC children with TB in Europe. METHODS: Multicentre, matched case-control study within the Paediatric Tuberculosis Network European Trials Group (ptbnet), capturing TB cases <18 years diagnosed 2000-2020...
April 3, 2024: Clinical Infectious Diseases
#4
JOURNAL ARTICLE
Tracy Ayers, Andrew N Hill, Julia Raykin, Sarita Mohanty, Robert W Belknap, Richard Brostrom, Renuka Khurana, Michael Lauzardo, Thaddeus L Miller, Masahiro Narita, April C Pettit, Alexandra Pyan, Katya L Salcedo, Araxi Polony, Jennifer Flood
IMPORTANCE: Elimination of tuberculosis (TB) disease in the US hinges on the ability of tests to detect individual risk of developing disease to inform prevention. The relative performance of 3 available TB tests-the tuberculin skin test (TST) and 2 interferon-γ release assays (IGRAs; QuantiFERON-TB Gold In-Tube [QFT-GIT] and SPOT.TB [TSPOT])-in predicting TB disease development in the US remains unknown. OBJECTIVE: To compare the performance of the TST with the QFT-GIT and TSPOT IGRAs in predicting TB disease in high-risk populations...
April 1, 2024: JAMA Network Open
#5
Priya R Chandrasekaran, Hiok Hong Chan, Tien-En Tan, Farah N I Ibrahim, Jinzhi Zhao, Kelvin Y C Teo
PURPOSE: To report a case of secondary Multiple Evanescent White Dot Syndrome in a patient with preexisting wet age-related macular degeneration. OBSERVATION: A 75-year-old male on treat and extend regimen for wet age-related macular degeneration (AMD) presented with a sudden loss of vision and saw central dark shadow in the right eye (RE) for a duration of 1 week. There was no significant history preceding the visual loss. Examination showed a visual acuity (VA) of counting fingers at 1 meter in the right eye and 20/25 in the left eye...
June 2024: American Journal of Ophthalmology Case Reports
#6
JOURNAL ARTICLE
Graciela Russomando, Diana Sanabria, Chyntia Carolina Díaz Acosta, Leticia Rojas, Laura Franco, Rossana Arenas, Giovanni Delogu, Mame Diarra Bousso Ndiaye, Rim Bayaa, Niaina Rakotosamimanana, Delia Goletti, Jonathan Hoffmann
INTRODUCTION: New diagnostic tools are needed to rapidly assess the efficacy of pulmonary tuberculosis (PTB) treatment. The aim of this study was to evaluate several immune biomarkers in an observational and cross-sectional cohort study conducted in Paraguay. METHODS: Thirty-two patients with clinically and microbiologically confirmed PTB were evaluated before starting treatment (T0), after 2 months of treatment (T1) and at the end of treatment (T2). At each timepoint plasma levels of IFN-y, 17 pro- and anti-inflammatory cytokines/chemokines and complement factors C1q, C3 and C4 were assessed in unstimulated and Mtb-specific stimulated whole blood samples using QuantiFERON-TB gold plus and recombinant Mycobacterium smegmatis heparin binding hemagglutinin (rmsHBHA) as stimulation antigen...
2024: Frontiers in Immunology
#7
Maria Filoftea Mercuț, Oana Maria Ică, Cornelia Andreea Tănasie, Răzvan Mercuț, Carmen Luminița Mocanu, Andreea Mihaela Nicolcescu, Ciprian Danielescu
Eales disease manifests as an obliterative periphlebitis affecting the retina; it originates from the periphery and progresses posteriorly. It is characterized by retinal vessel wall inflammation, ischemia, and retinal neovascularization. In this report, we present the case of a 34-year-old male who attended our clinic with a sudden blurring of vision in his right eye. A diagnosis of bilateral retinal vasculitis with vitreal hemorrhage was ascertained in his RE. A dilated ocular fundus examination revealed perivenous sheathing of the peripheral vessels in both eyes...
February 22, 2024: Journal of Personalized Medicine
#8
JOURNAL ARTICLE
Setareh Mamishi, Babak Pourakbari, Reihaneh Hosseinpour Sadeghi, Majid Marjani, Shima Mahmoudi
The diagnosis of extrapulmonary tuberculosis (EPTB) poses a significant challenge, with controversies surrounding the accuracy of IFN-γ release assays (IGRAs). This study aimed to assess the diagnostic accuracy of RD1 immunodominant T-cell antigens, including ESAT-6, CFP-10, PE35, and PPE68 proteins, for immunodiagnosis of EPTB. Twenty-nine patients with EPTB were enrolled, and recombinant PE35, PPE68, ESAT-6, and CFP-10 proteins were evaluated in a 3-day Whole Blood Assay. IFN-γ levels were measured using a Human IFN-γ ELISA kit, and the QuantiFERON-TB Gold Plus (QFT-Plus) test was performed...
March 26, 2024: FEMS Microbiology Letters
#9
JOURNAL ARTICLE
Bi Ran, Jiangyue Qin, Yanqiu Wu, Fuqiang Wen
BACKGROUND: People are constantly exposed to phthalates, but few reliable studies have focused on the connection between phthalate exposure and latent tuberculosis infection (LTBI). METHODS: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) database (2011-2012). The LTBI was assessed by QuantiFERON®-TB Gold-In-Tube (QFT) or tuberculin skin testing (TST). The odds ratios (ORs) and 95% confidence intervals (CIs) per log10 unit change in the concentration of phthalate metabolites were calculated using crude and adjusted logistic regression models...
March 30, 2024: Heliyon
#10
JOURNAL ARTICLE
Julia Xia, Alan G Palestine, Amit K Reddy
PURPOSE: To evaluate the diagnostic value of QuantiFERON Gold (QFT-G) testing for ocular inflammation in a low prevalence tuberculosis (TB) area. DESIGN: Diagnostic utility analysis. METHODS: A review was performed for all uveitis patients who underwent QFT-G testing at the University of Colorado Eye Center from 2009-2022. Records were reviewed to assess QFT-G positivity rate and to identify which patients were tested for diagnostic purposes, defined as meeting the Standardization of Uveitis Nomenclature (SUN) criteria for tubercular uveitis (TBU): anterior uveitis with iris nodules, serpiginous-like choroiditis, choroidal nodule resembling a tuberculoma, multifocal choroiditis, or occlusive retinal vasculitis...
March 20, 2024: American Journal of Ophthalmology
#11
JOURNAL ARTICLE
Nejla Stambouli, Khadija Bahrini, Chihebeddine Romdhani, Aicha Rebai, Sana Boughariou, Mohamed Zakraoui, Bilel Arfaoui, Sameh Seyli, Yasmine Boukhalfa, Riadh Battikh, Mohamed Ben Moussa, Iheb Labben, Mustpha Ferjani, Hedi Gharssallah
On March 13, 2021, Tunisia started a widespread immunization program against SARS-CoV-2 utilizing different vaccinations that had been given emergency approval. Herein, we followed prospectively a cohort of participant who received COVID-19 vaccine (Pfizer BioNTech and Sputnik-Gameleya V). The goal of this follow-up was to define the humoral and cellular immunological profile after immunization by assessing neutralizing antibodies and IFN- γ release. 26 vaccinated health care workers by Pfizer BioNTech (n = 12) and Sputnik-Gameleya V (n = 14) were enrolled from June to December 2021 in Military hospital of Tunis...
March 13, 2024: Journal of Immunological Methods
#12
JOURNAL ARTICLE
Argita D Salindri, Sara C Auld, Unjali P Gujral, Elaine M Urbina, Jason R Andrews, Moises A Huaman, Matthew J Magee
OBJECTIVES: Tuberculosis infection (TBI) is marked by dynamic host-pathogen interactions with persistent low-grade inflammation and is associated with increased risk of cardiovascular diseases (CVD) including acute coronary syndrome, myocardial infarction and stroke. However, few studies assess the relationship between TBI and hypertension, an intermediate of CVD. We sought to determine the association between TBI and hypertension using data representative of the adult US population. METHODS: We performed cross-sectional analyses using data from the 2011-2012 US National Health and Nutrition Examination Survey (NHANES)...
March 12, 2024: BMJ Open
#13
JOURNAL ARTICLE
Tomas M Perez-Porcuna, Antoni Noguera-Julian, Maria Teresa Riera-Bosch, Esperança Macià-Rieradevall, José Santos-Santiago, Maria Àngels Rifà Pujol, Maria Eril, Lídia Aulet-Molist, Emma Padilla-Esteba, Maria Teresa Tórtola, Jordi Gómez I Prat, Anna Vilamala Bastarras, Josep Sebastià Rebull-Fatsini, Andrea Papaleo, Neus Rius-Gordillo, Alessandra Q Gonçalves, Àngels Naranjo-Orihuela, Marta Urgelles, Mónica G García-Lerín, Gemma Jimenez-Lladser, Beatriz Lorenzo-Pino, Mónica Adriana Giuliano-Cuello, Maria Teresa Pascual-Sánchez, Mónica Marco-García, Rosa Abellana, Maria Espiau, Maria Nieves Altet-Gómez, Angels Orcau-Palau, Joan A Caylà, Antoni Soriano-Arandes
BACKGROUND: Most paediatric tuberculosis (TB) cases in low-TB-incidence countries involve children born to migrant families. This may be partially explained by trips to their countries of origin for visiting friends and relatives (VFR). We aimed to estimate the risk of latent TB infection (LTBI) and TB in children VFR. METHODS: We conducted a prospective multicentric observational study in Catalonia (Spain) from 06/2017 to 12/2019. We enrolled children aged < 15 years with a negative tuberculin skin test (TST) at baseline and at least one parent from a high-TB-incidence country, and who had travelled to their parent's birth country for ≥21 days...
March 4, 2024: Journal of Travel Medicine
#14
JOURNAL ARTICLE
Paulo Cesar Pereira Dos Santos, Nicole Louise Messina, Roberto Dias de Oliveira, Patricia Vieira da Silva, Marco Antonio Moreira Puga, Margareth Dalcolmo, Glauce Dos Santos, Marcus Vinícius Guimarães de Lacerda, Bruno Araújo Jardim, Fernando Fonseca de Almeida E Val, Nigel Curtis, Jason R Andrews, Julio Croda
BACKGROUND: The effectiveness of BCG vaccine for adult pulmonary tuberculosis remains uncertain. In this study, we aimed to evaluate the effect of vaccination with BCG-Denmark to prevent initial and sustained interferon-γ release assay conversion in Brazilian health-care workers. METHODS: This substudy is a nested randomised controlled trial embedded within the BRACE trial (NCT04327206). Specifically, this substudy enrolled Brazilian health-care workers (aged ≥18 years) from three sites in Brazil (Manaus, Campo Grande, and Rio de Janeiro) irrespective of previously receiving BCG vaccination...
February 26, 2024: Lancet Infectious Diseases
#15
JOURNAL ARTICLE
Prevalence of latent tuberculosis infection in Asian nations: A systematic review and meta-analysis.
Abhigan B Shrestha, Imran S Siam, Jarin Tasnim, Abhinav Dahal, Poulami Roy, Sushil Neupane, Ashok Adhikari, Barsha Khanal, Rupesh Ghimirie, Dikshya Shrestha, Suju Bhattarai, Sajina Shrestha, Nischal Mainali, Yubraj Sedai, Uday Singh
BACKGROUND: Tuberculosis (TB) is a serious public health concern around the world including Asia. TB burden is high in Asian countries and significant population harbor latent tuberculosis infection(LTBI). AIM: This systematic review and meta-analysis aims to evaluate the prevalence of LTBI in Asian countries. METHOD: We performed a systematic literature search on PubMed, Embase, and ScienceDirect to identify relevant articles published between January 1, 2005, and January 1, 2023 investigating the overall prevalence of latent TB among people of Asia...
February 2024: Immunity, Inflammation and Disease
#16
JOURNAL ARTICLE
Jee Whang Kim, Joshua Nazareth, Joanne Lee, Hemu Patel, Gerrit Woltmann, Raman Verma, Anne O'Garra, Pranabashis Haldar
OBJECTIVES: We investigated whether quantifying the serial QuantiFERON-TB Gold (QFT) response improves tuberculosis (TB) risk stratification in pulmonary TB (PTB) contacts. METHODS: 297 untreated adult household PTB contacts, QFT tested at baseline and 3 months after index notification, were prospectively observed (median 1460 days). Normal variance of serial QFT responses was established in 46 extra-pulmonary TB contacts. This informed categorisation of the response in QFT-positive PTB contacts as: converters; persistently QFT-positive with significant increase (PPincrease ); and without significant increase (PPno-increase )...
February 24, 2024: International Journal of Infectious Diseases: IJID
#17
JOURNAL ARTICLE
Ilona Součková, Ondřej Souček, Jan Krejsek, Oldřich Vyšata, David Matyáš, Marek Peterka, Michal Novotný, Pavel Kunc, Zbyšek Pavelek
The aim of this study was to conduct QuantiFERON Monitor (QFM) testing in patients with multiple sclerosis (MS), which is used to monitor the state of the immune system through the non-specific stimulation of leukocytes followed by determining the level of interferon-gamma (IFN-γ) released from activated cells. Additionally, we tested the level of selected cytokines (IFN-α, IFN-γ, IL-1α, IL-1β, IL-1ra, IL-2, IL-3, IL-4, IL-6, IL-7, IL-10, IL-15, IL-33, VEGF) from stimulated blood samples to further understand the immune response...
February 11, 2024: International Journal of Molecular Sciences
#18
Philip Nolan, Sanya Samad, Thomas Kiernan
This paper reports on the unlikely case of a 68-year-old man presenting with a non-resolving, mild lower respiratory tract infection, subsequently diagnosed with pericardial tuberculosis (TB) in the absence of TB risk factors and with negative TB serology. Pericardial and pleural effusions were found incidentally on CT pulmonary angiogram, with a small pericardial effusion without tamponade seen on the echocardiogram. During his three-month inpatient stay, the patient was rarely very unwell, though no treatment led to clinical and biochemical resolution of symptoms...
January 2024: Curēus
#19
JOURNAL ARTICLE
Raquel Fernández-Moreno, Aurora Páez-Vega, Diego Rodríguez-Cano, Ana Salinas, Fernando Rodríguez-Cantalejo, Aurora Jurado, Julián Torre-Cisneros, Sara Cantisán
BACKGROUND: The QuantiFERONCMV (QF-CMV) assay is an interferon-gamma release assay (IGRA) used to monitor CMV-specific cell-mediated immunity (CMV-CMI) by ELISA in transplant patients. However, a chemiluminescent immunoassay (CLIA) has been developed to quantify IFNG in the QuantiFERON-Tuberculosis (TB) to detect latent TB infection. OBJECTIVES: The aim of this work is to compare the results of QF-CMV by ELISA with those obtained by CLIA in an automated Liaison XL analyzer using the QuantiFERON-TB Gold Plus reagents...
February 8, 2024: Journal of Clinical Virology
#20
JOURNAL ARTICLE
Henan Xin, Xuefang Cao, Boxuan Feng, YiJun He, Tonglei Guo, Jiang Du, Lingyu Shen, Yuanzhi Di, Zisen Liu, Dakuan Wang, Bin Zhang, Zhanjiang Zhang, Xueling Guan, Fei Shen, Ling Guan, Shougao Pan, Weitao Duan, Qi Jin, Lei Gao
BACKGROUND: Recurrence posed an important challenge to pulmonary tuberculosis (PTB) control in China. The prospective study aimed to identify potential risk factors and to explore the value of QuantiFERON-TB Gold Plus (QFT-Plus) in identifying at-risk individuals with treated prior PTB history. METHODS: All eligible individuals aged ≥18 years who had been diagnosed with PTB before 2016 in Zhongmu County, where with an average level of TB prevalence in China, were included and received baseline survey including chest radiography, QuantiFERON-TB Gold In-Tube (QFT-GIT) and QFT-Plus, then PTB recurrence was tracked through a 2-year follow-up...
February 6, 2024: Infectious Diseases
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