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https://www.readbyqxmd.com/read/29348638/changes-in-cytokine-responses-to-tb-antigens-esat-6-cfp-10-and-tb-7-7-and-inflammatory-markers-in-peripheral-blood-during-therapy
#1
Ah Young Leem, Joo Han Song, Eun Hye Lee, Hyejon Lee, Bora Sim, Song Yee Kim, Kyung Soo Chung, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Joon Chang, Young Ae Kang
Multiple cytokines and inflammatory markers control TB infection. We aimed to investigate the changes in multiple cytokines and inflammatory markers in active TB patients following anti-TB drug therapy. Twenty-nine patients with active TB were recruited prospectively between December 2010 and July 2017. Blood samples were collected before (T0), after 2 months (T2), and at the end of anti-TB treatment (Tend). We measured the levels of Interferon (IFN)-γ, interleukin (IL)-2, IL-12, IL-10, IL-13 and tumor necrosis factor (TNF)-α in supernatants collected from the QuantiFERON-TB Gold In-Tube assay (QFT-GIT), as well as the WBC, neutrophil, platelet count and neutrophil to lymphocyte ratio (NLR) in whole blood...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348181/intensity-of-exposure-to-pulmonary-tuberculosis-determines-risk-of-tuberculosis-infection-and-disease
#2
Carlos Acuña-Villaorduña, Edward C Jones-López, Geisa Fregona, Patricia Marques-Rodrigues, Mary Gaeddert, Carolina Geadas, David Jamil Hadad, Laura F White, Lucilia Pereira Dutra Molina, Solange Vinhas, Rodrigo Ribeiro-Rodrigues, Padmini Salgame, Moises Palaci, David Alland, Jerrold J Ellner, Reynaldo Dietze
Household contacts of pulmonary tuberculosis (TB) patients are at increased risk of TB infection and disease. However, their risk in relation to the intensity of exposure remains unknown.We studied smear-positive TB cases and their household contacts in Vitória, Brazil. We collected clinical, demographic and radiographic information from TB cases, and obtained tuberculin skin test (TST) and QuantiFERON-TB Gold (QFT) results from household contacts. We measured intensity of exposure using a proximity score and sleep location in relation to the TB index case and defined infection by TST ≥10 mm or QFT ≥0...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29345081/screening-for-latent-tuberculosis-infection-among-patients-with-rheumatoid-arthritis-in-the-era-of-biologics-and-targeted-synthetic-disease-modifying-anti-rheumatic-drugs-in-india-a-high-burden-tb-country-the-importance-of-mantoux-and-quantiferon-tb-gold-tests
#3
Anand N Malaviya, Vishal K Aggarwal, Roopa Rawat, Sadhana Baghel, Ravita Thakran, Qamar Zaheer, Shriram Garg, Sanjiv Kapoor
AIM: To test the validity of an augmented tuberculosis skin test (a-TST) combined with Quantiferon TB-gold® (QFTG) test for the screening of latent tuberculosis infection (LTBI) in patients with rheumatoid arthritis (RA) being considered for treatment with biologic disease-modifying anti-rheumatic drugs or targeted synthetic disease-modifying anti-rheumatic drugs. METHOD: Standard TST using 1 tuberculin unit (TU) of purified protein derivative (PPD, RT23 strain) was carried out...
January 17, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29343541/immune-monitoring-of-infectious-complications-in-transplant-patients-an-important-step-towards-improved-clinical-management
#4
Rajiv Khanna
Immune reconstitution following organ transplantation is absolutely critical in preventing infectious complications. However, understanding the kinetics of immune reconstitution and its potential impact on the clinical management of transplant patients remains a significant challenge. Over the last decade, various platform technologies have emerged which have provided important insights into the immune reconstitution kinetics in transplant patients. However, many of these technologies are too complicated and cumbersome to implement in a clinical setting...
January 17, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29334817/quantiferon-plus-does-not-discriminate-between-active-and-latent-tuberculosis
#5
Regina W Hofland, Aik W J Bossink, Stefan Nierkens, Sanne P A Paardekooper, Brigitte T A van den Broek, Jan-Willem J Lammers, Ineke van Haeften, Steven F T Thijsen
No abstract text is available yet for this article.
January 15, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29331844/assessing-the-risk-of-cmv-reactivation-and-reconstitution-of-antiviral-immune-response-post-bone-marrow-transplantation-by-the-quantiferon-cmv-assay-and-real-time-pcr
#6
Adalbert Krawczyk, Jessica Ackermann, Birgit Goitowski, Rudolf Trenschel, Markus Ditschkowski, Jörg Timm, Hellmut Ottinger, Dietrich W Beelen, Nico Grüner, Melanie Fiedler
BACKGROUND: CMV reactivation is a major cause of severe complications in allogeneic hematopoietic stem cell transplant (HSCT) recipients. The risk of CMV reactivation depends on the serostatus (+/-) of the donor (D) and recipient (R). The reconstitution of CMV-specific T-cell responses after transplantation is crucial for the control of CMV reactivation. OBJECTIVES: The study aimed to determine the cellular immune status correlating with protection from high-level CMV viremia (>5000 copies/ml) and disease...
January 9, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29325465/prevalence-of-positive-quantiferon-gold-in-tube-testing-in-hidradenitis-suppurativa
#7
Tina Boortalary, Kanchan Misra, Sean McNish, Derek Jones, Victoria K Shanmugam
Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disease of the apocrine sweat glands. Tumor necrosis factor-alpha (TNF-α) inhibitors are commonly used to treat HS. However, prior to initiating therapy patients must be screened for mycobacterium tuberculosis (mTB) exposure. Several mTB screening tests based on interferon gamma release assays are commercially available, but the performance of these assays in the HS population is unknown. The purpose of this study was to investigate the performance of the QuantiFERON gold in-tube assay (QFT-GIT) in a cohort of patients with Hidradenitis suppurativa (HS)...
January 12, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29321075/a-phase-i-open-label-trial-on-the-safety-and-immunogenicity-of-the-adjuvanted-tuberculosis-subunit-vaccine-h1-ic31%C3%A2-in-people-living-in-a-tb-endemic-area
#8
Jemal Hussein, Martha Zewdie, Lawrence Yamuah, Ahmed Bedru, Markos Abebe, Alemnew F Dagnew, Menberework Chanyalew, Asfawesen G Yohannes, Jemal Ahmed, Howard Engers, T Mark Doherty, Peter Bang, Ingrid Kromann, Søren T Hoff, Abraham Aseffa
BACKGROUND: H1/IC31® is a tuberculosis (TB) subunit vaccine candidate consisting of the fusion protein of Ag85B and ESAT-6 (H1) formulated with the IC31® adjuvant. Previous trials have reported on the H1/IC31® vaccine in M. tuberculosis (Mtb)-naïve, BCG-vaccinated and previously Mtb-infected individuals. In this trial, conducted between December 2008 and April 2010, the safety and immunogenicity of H1/IC31® was assessed in participants living in Ethiopia - a highly TB-endemic area...
January 10, 2018: Trials
https://www.readbyqxmd.com/read/29311240/potential-immunological-biomarkers-for-detection-of-mycobacterium-tuberculosis-infection-in-endemic-setting-ethiopia
#9
Takele Teklu, Kwon Keehwan, Biniam Wondale, Milkessa HaileMariam, Mengistu Legesse, Girmay Medhin, Aboma Zewude, Rembert Pieper, Gobena Ameni
Accurate diagnosis and early treatment of tuberculosis (TB) and latent TB infection (LTBI) are vital to prevent and control TB. The lack of specific biomarkers hinders these efforts. This study's purpose was to screen immunological markers that discriminate M. tuberculosis (Mtb) infection outcomes in an endemic setting of Ethiopia. Whole blood from 90 participants was stimulated using the ESAT-6/CFP-10 antigen cocktail. The interferon-γ (IFN-γ)-based QuantiFERON diagnostic test was used to distinguish between LTBI and uninfected control cases...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29305542/monitoring-of-cmv-specific-cell-mediated-immunity-in-heart-transplant-recipients-clinical-utility-of-the-quantiferon%C3%A2-cmv-assay-for-the-management-of-post-transplant-cmv-infection
#10
Angela Chiereghin, Luciano Potena, Laura Borgese, Dino Gibertoni, Diego Squarzoni, Gabriele Turello, Evangelia Petrisli, Giulia Piccirilli, Liliana Gabrielli, Francesco Grigioni, Tiziana Lazzarotto
Background: The clinical utility of QuantiFERON®-CMV (QFN®-CMV) assay in heart transplant recipients was assessed.Methods: Forty-four CMV-seropositive patients were enrolled: 17 received antiviral prophylaxis and 27 were managed pre-emptively. CMV-DNAemia monitoring was performed by a quantitative real-time PCR assay. QFN®-CMV assay was retrospectively performed on blood samples collected at five post-transplant time-points.Results: A higher proportion of patients with indeterminate QFN®-CMV result after the suspension of prophylaxis developed CMV infection compared to patients who showed a global T-cell responsiveness (P=0...
January 5, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29281051/evaluation-of-a-novel-global-immunity-assay-to-predict-infection-in-organ-transplant-recipients
#11
Muhtashim Mian, Yoichiro Natori, Victor Ferreira, Nazia Selzner, Shahid Husain, Lianne Singer, S Joseph Kim, Atul Humar, Deepali Kumar
Background: Solid organ transplant recipients (SOTRs) are predisposed to infection due to the need for lifelong immunosuppression, although tools to measure the overall degree of immunosuppression are limited. In this study, we used a novel global cell-mediated immunity (CMI) assay to quantify the degree of immunosuppression and predict subsequent infections. Methods: Consecutive SOTRs were enrolled and provided whole blood to conduct the global CMI assay (QuantiFERON Monitor) at 1, 3, and 6 months posttransplant...
December 21, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29277097/systemic-review-agreement-between-the-latent-tuberculosis-screening-tests-among-patients-with-rheumatic-diseases
#12
Junhee Pyo, Soo-Kyung Cho, Dam Kim, Yoon-Kyoung Sung
Background/Aims: To estimate the level of agreement and positivity rates of latent tuberculosis infection (LTBI) tests prior to the use of tumor necrosis factor (TNF) inhibitors in relation to underlying rheumatic diseases and endemic tuberculosis levels. Methods: The Ovid-Medline, Embase, and Cochrane Libraries were searched for articles before October 2013 involving LTBI screening in rheumatic patients, including rheumatoid arthritis (RA), ankylosing spondylitis (AS), juvenile idiopathic arthritis (JIA), and psoriatic arthritis...
December 28, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29232714/cytomegalovirus-cmv-immune-monitoring-with-elispot-and-quantiferon-cmv-assay-in-seropositive-kidney-transplant-recipients
#13
Hyeyoung Lee, Ki Hyun Park, Ji Hyeong Ryu, Ae-Ran Choi, Ji Hyun Yu, Jihyang Lim, Kyungja Han, Sang Il Kim, Chul Woo Yang, Byung Ha Chung, Eun-Jee Oh
Although cytomegalovirus (CMV) specific cell-mediated immunity (CMI) has been suggested as a predictive marker for CMV infection, proper CMI monitoring strategy in CMV-seropositive recipients and optimal method are not defined. The aim of this study was to evaluate two interferon gamma release assays during early post-transplant period as a predictor of the development of CMV infection in CMV-seropositive patients. A total of 124 CMV-seropositive recipients who received kidney transplantation from CMV-seropositive donor were prospectively examined...
2017: PloS One
https://www.readbyqxmd.com/read/29228845/correction-to-choi-et-al-diagnostic-usefulness-of-the-quantiferon-tb-gold-in-tube-test-qft-git-for-tuberculous-vertebral-osteomyelitis
#14
(no author information available yet)
No abstract text is available yet for this article.
December 12, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29218257/pulmonary-tuberculosis-versus-recurrent-chemotherapy-induced-pneumonitis-a-clinical-dilemma
#15
Gulrayz Ahmed, Muhammad W Saif
Chemotherapy-induced lung toxicity can affect pulmonary parenchyma, pleura, airways, pulmonary vascular system, mediastinum or the neuromuscular system that is responsible for respiration. Chemotherapy-induced pulmonary toxicity is a diagnosis of exclusion. When the patients with malignancies develop pulmonary toxicity such as pneumonitis and distinguishing it from alternative diseases such as infectious, thrombotic, cardiac, malignant or exacerbation of chronic lung conditions can be difficult. Moreover, such patients are often immunosuppressed, physically stressed from the underlying disease and the cancer treatment and hence, more susceptible to usual and unusual or opportunistic infections...
October 4, 2017: Curēus
https://www.readbyqxmd.com/read/29216851/what-does-igra-testing-add-to-the-diagnosis-of-ocular-tuberculosis-a-bayesian-latent-class-analysis
#16
Rupesh Agrawal, Robert Grant, Bhaskar Gupta, Dinesh Visva Gunasekeran, Julio J Gonzalez-Lopez, Peter K F Addison, Mark Westcott, Carlos E Pavesio
BACKGROUND: To evaluate the contribution made to the diagnostic work-up for patients with suspected ocular tuberculosis (TB) by QuantiFERON-TB Gold In-Tube (QFT) tests using latent class analysis model. METHODS: A single centre retrospective cohort study. A Bayesian latent class model was constructed on the basis of demographics, phenotypes and test results from patients attending a tertiary referral center in the UK. This estimated the probability of ocular TB for each patient in two versions, first with and then without QFT...
December 8, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29216277/immune-mediated-inflammatory-diseases-differently-affect-igras-accuracy-for-latent-tuberculosis-infection-diagnosis-in-clinical-practice
#17
Irene Latorre, Sonia Mínguez, José-Manuel Carrascosa, Juan Naves, Raquel Villar-Hernández, Beatriz Muriel, Cristina Prat, Esther García-García, Irma Casas, Eugeni Domènech, Carlos Ferrándiz, Lourdes Mateo, Jose Domínguez
BACKGROUND: Clinical accuracy of IGRAs remains unclear on patients with immune-mediated inflammatory diseases (IMIDs). Here, we assess the impact of immunosuppressants and IMIDs on QuantiFERON-TB Gold In-Tube (QFN-G-IT) and T-SPOT.TB accuracy. METHODS: Patients with IMIDs who required latent tuberculosis infection (LTBI) screening were enrolled and classified into: (i) 50 patients with inflammatory rheumatic diseases, (ii) 50 patients with psoriasis and (iii) 30 patients with Crohn's disease...
2017: PloS One
https://www.readbyqxmd.com/read/29196694/latent-tuberculosis-infection-among-patients-with-erectile-dysfunction
#18
Ahmad F A Hasanain, Ali M A Mahran, Ahmed S Safwat, Amany M A Nafee, Ali A H Zayed, Sherif M Abdel-Aal, Sally M Bakkar, Ahmad Elbadry I Abonnoor
No previous studies have investigated the prevalence of latent tuberculosis infection (LTBI) among patients with erectile dysfunction (ED) or its contribution to the development of high-grade ED through a process of chronic inflammation-induced atherosclerosis. The aim of this study was to determine the frequency of LTBI among patients with erectile dysfunction and to explore the contribution of LTBI to high-grade ED. For all the study sample, clinical evaluation, imaging studies, and laboratory investigations were provided...
December 1, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29189087/diagnostic-usefulness-of-the-quantiferon-tb-gold-in-tube-test-qft-git-for-tuberculous-vertebral-osteomyelitis
#19
Sungim Choi, Kyung Hwa Jung, Hyo-Ju Son, Seung Hyun Lee, Jung Min Hong, Min Chul Kim, Min Jae Kim, Yong Pil Chong, Heungsup Sung, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim
BACKGROUND: Interferon (IFN)-γ-releasing assay for diagnosing tuberculosis (TB) has shown promise; however, there are only a few reports on usefulness of the QuantiFERON-TB Gold In-Tube test (QFT-GIT) for diagnosing TB vertebral osteomyelitis. METHODS: All patients presenting at a tertiary hospital between January 2010 and July 2016 with suspected TB vertebral osteomyelitis were retrospectively enrolled to evaluate the diagnostic performance of QFT-GIT. We used QFT-GIT to measure the IFN-γ response to ESAT-6, CFP-10 and TB7...
November 30, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29182688/interferon-gamma-release-assay-for-the-diagnosis-of-latent-tuberculosis-infection-a-latent-class-analysis
#20
Tan N Doan, Damon P Eisen, Morgan T Rose, Andrew Slack, Grace Stearnes, Emma S McBryde
BACKGROUND: Accurate diagnosis and subsequent treatment of latent tuberculosis infection (LTBI) is essential for TB elimination. However, the absence of a gold standard test for diagnosing LTBI makes assessment of the true prevalence of LTBI and the accuracy of diagnostic tests challenging. Bayesian latent class models can be used to make inferences about disease prevalence and the sensitivity and specificity of diagnostic tests using data on the concordance between tests. We performed the largest meta-analysis to date aiming to evaluate the performance of tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) for LTBI diagnosis in various patient populations using Bayesian latent class modelling...
2017: PloS One
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