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https://www.readbyqxmd.com/read/28225955/the-role-of-intradermal-proliferation-of-t-cells-in-the-pathogenesis-of-psoriasis
#1
Vladislav R Khairutdinov, Anastasiya F Mikhailichenko, Irena E Belousova, Ekatherina Sh Kuligina, Alexey V Samtsov, Evgeny N Imyanitov
BACKGROUND: Psoriasis is a common immune-mediated chronic inflammatory disease of the skin and joints, affecting 1-3% of the population. It is generally accepted that the pathogenesis of psoriasis involves accumulation of effector T-cells within lymph nodes and their subsequent migration into the skin through the blood system. Here we provide evidence that psoriatic plaque itself may serve as a source of inflammatory T-cells. OBJECTIVE: We examined the intradermal proliferation of T-cells and the number of effector/memory (CD45RO+) T-cells in the skin of psoriatic patients at different periods of the disease...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28217963/divergent-methylation-pattern-in-adult-stage-between-two-forms-of-tetranychus-urticae-koch-acari-tetranychidae
#2
Si-Xia Yang, Chao Guo, Xiu-Ting Zhao, Jing-Tao Sun, Xiao-Yue Hong
The two-spotted spider mite, Tetranychus urticae Koch has two forms: green form and red form. Understanding the molecular basis of how these two forms established without divergent genetic background is an intriguing area. As a well-known epigenetic process, DNA methylation has particularly important roles in gene regulation and developmental variation across diverse organisms that not alter genetic background. Here, to investigate whether DNA methylation could be associated with different phenotypic consequences in T...
February 19, 2017: Insect Science
https://www.readbyqxmd.com/read/28217865/caching-reduces-kleptoparasitism-in-a-solitary-large-felid
#3
Guy A Balme, Jennifer R B Miller, Ross T Pitman, Luke T B Hunter
Food caching is a common strategy used by a diversity of animals, including carnivores, to store and/or secure food. Despite its prevalence, the drivers of caching behaviour, and its impacts on individuals, remain poorly understood, particularly for short-term food cachers. Leopards Panthera pardus exhibit a unique form of short-term food caching, regularly hoisting, storing, and consuming prey in trees. We explored the factors motivating such behaviour among leopards in the Sabi Sand Game Reserve, South Africa, associated with four not mutually exclusive hypotheses: food-perishability, consumption-time, resource-pulse, and kleptoparasitism-avoidance...
February 19, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28215331/a-user-s-guide-for-characterizing-plasma-membrane-subdomains-in-living-cells-by-spot-variation-fluorescence-correlation-spectroscopy
#4
S Mailfert, Y Hamon, N Bertaux, H-T He, D Marguet
Due to the intrinsic molecular Brownian agitation within plasma membrane and the vast diversity of membrane components, it is expected that the plasma membrane organization is highly heterogeneous with the formation of local complex multicomponent assemblies of lipids and proteins on different time scales. Still, deciphering this lateral organization on living cells and on the appropriate length and temporal scales has been challenging but is crucial to advance our knowledge on the biological function of the plasma membrane...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28212681/toxoplasma-gondii-survey-in-cats-from-two-environments-of-the-city-of-rio-de-janeiro-brazil-by-modified-agglutination-test-on-sera-and-filter-paper
#5
Paula F Bolais, Philippe Vignoles, Pamela F Pereira, Rafael Keim, Abdelkrim Aroussi, Khadja Ismail, Marie-Laure Dardé, Maria Regina Amendoeira, Aurélien Mercier
BACKGROUND: Toxoplasma gondii is a protozoan with a worldwide distribution, in warm-blood animals, including humans. Local conditions and environmental disturbances may influence transmission dynamics of a zoonotic agent. This study evaluates the epidemiology of T. gondii based on toxoplasmosis prevalence in two populations of cats living in distinct urbanization conditions in Rio de Janeiro, Brazil. METHODS: Among 372 domestic cats sampled, 265 were from a public shelter located downtown Rio and 107 from a relatively preserved wild environment in a residential area...
February 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28196830/the-benefits-of-data-linkage-for-firefighter-injury-surveillance
#6
Shannon A Widman, Michael T LeVasseur, Loni P Tabb, Jennifer A Taylor
BACKGROUND: While survey data are available for national estimates of fire events and firefighter fatalities, data on firefighter injury at the national and local levels remain incomplete and unreliable. Data linkage provides a vehicle to maximise case detection and deepen injury description for the US fire service. METHODS: By linking departmental Human Resources records, despatch data, workers' compensation and first reports of injury, researchers were able to describe reported non-fatal injuries to 3063 uniformed members of the Philadelphia Fire Department (PFD), for the period of 2005 through 2013...
February 14, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28187177/a-comparison-of-ki-67-counting-methods-in-luminal-breast-cancer-the-average-method-vs-the-hot-spot-method
#7
Min Hye Jang, Hyun Jung Kim, Yul Ri Chung, Yangkyu Lee, So Yeon Park
In spite of the usefulness of the Ki-67 labeling index (LI) as a prognostic and predictive marker in breast cancer, its clinical application remains limited due to variability in its measurement and the absence of a standard method of interpretation. This study was designed to compare the two methods of assessing Ki-67 LI: the average method vs. the hot spot method and thus to determine which method is more appropriate in predicting prognosis of luminal/HER2-negative breast cancers. Ki-67 LIs were calculated by direct counting of three representative areas of 493 luminal/HER2-negative breast cancers using the two methods...
2017: PloS One
https://www.readbyqxmd.com/read/28183841/mathematical-modeling-links-wnt-signaling-to-emergent-patterns-of-metabolism-in-colon-cancer
#8
Mary Lee, George T Chen, Eric Puttock, Kehui Wang, Robert A Edwards, Marian L Waterman, John Lowengrub
Cell-intrinsic metabolic reprogramming is a hallmark of cancer that provides anabolic support to cell proliferation. How reprogramming influences tumor heterogeneity or drug sensitivities is not well understood. Here, we report a self-organizing spatial pattern of glycolysis in xenograft colon tumors where pyruvate dehydrogenase kinase (PDK1), a negative regulator of oxidative phosphorylation, is highly active in clusters of cells arranged in a spotted array. To understand this pattern, we developed a reaction-diffusion model that incorporates Wnt signaling, a pathway known to upregulate PDK1 and Warburg metabolism...
February 9, 2017: Molecular Systems Biology
https://www.readbyqxmd.com/read/28183839/mr-imaging-of-individual-perfusion-reorganization-using-superselective-pseudocontinuous-arterial-spin-labeling-in-patients-with-complex-extracranial-steno-occlusive-disease
#9
V Richter, M Helle, M J P van Osch, T Lindner, A S Gersing, P Tsantilas, H-H Eckstein, C Preibisch, C Zimmer
BACKGROUND AND PURPOSE: Patients with multiple stenoses or occlusions of the extracranial arteries require an individualized diagnostic approach. We evaluated the feasibility and clinical utility of a novel MR imaging technique for regional perfusion imaging in this patient group. MATERIALS AND METHODS: Superselective pseudocontinuous arterial spin-labeling with a circular labeling spot enabling selective vessel labeling was added to routine imaging in a prospective pilot study in 50 patients (10 women, 70...
February 9, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28182333/gnawing-at-striping-how-rodents-evolve-striped-patterns
#10
Robert N Kelsh, Kleio Petratou
Pigment patterns throughout the animal kingdom repeatedly utilise shared motifs (solid spots, hollow spots, stripes in different orientations), begging the question of whether these are generated by the same or different mechanisms in each case. Although intuitively this might seem unlikely, a whole body of work on mathematical modelling of these patterns suggests that, in theory at least, all such patterns could share an underlying mechanism. Within the mammals, one such motif is alternating longitudinal dark and light stripes, whether the supremely contrasting facial stripes of European Meles meles and American Badgers Taxidea taxus or the more subtle and more numerous stripes of the head, flanks and back of chipmunks, Tamias...
February 9, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28178767/probiotic-bacteria-inhibit-the-bovine-respiratory-pathogen-mannheimia-haemolytica-serotype-1-in-vitro
#11
S Amat, S Subramanian, E Timsit, T W Alexander
This study evaluated the potential of probiotic bacteria to inhibit growth and cell adhesion of the bovine respiratory pathogen Mannheimia haemoltyica serotype 1. The inhibitory effects of nine probiotic strains (Lactobacillus acidophilus, L. casei, L. helveticus, L. plantarum, L. rhamnosus, Lactococcus lactis, Streptococcus thermophilus and two Paenibacillus polymyxa strains) against M. haemolytica were evaluated using a spot-on-lawn method. Probiotic strains were then tested for their adherence to bovine bronchial epithelial (BBE) cells and the ability to displace and compete against M...
February 8, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28176296/brca1-and-brca2-mutations-in-ovarian-cancer-patients-from-china-ethnic-related-mutations-in-brca1-associated-with-an-increased-risk-of-ovarian-cancer
#12
Tingyan Shi, Pan Wang, Caixia Xie, Sheng Yin, Di Shi, Congchong Wei, Wenbin Tang, Rong Jiang, Xi Cheng, Qingyi Wei, Qing Wang, Rongyu Zang
BRCA1/2 are cancer predisposition genes involved in hereditary breast and ovarian cancer (HBOC). Mutation carriers display an increased sensitivity to inhibitors of poly (ADP-ribose) polymerase (PARP). Despite a number of small-size hospital-based studies being previously reported, there is not yet, to our knowledge, precise data of BRCA1/2 mutations among Chinese ovarian cancer patients. We performed a multicenter cohort study including 916 unselected consecutive epithelial ovarian cancer (EOC) patients from eastern China, to screen for BRCA1/2 mutations using the next-generation sequencing approach...
February 8, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28167148/the-association-between-male-biased-sex-ratio-and-indicators-of-stress-in-red-spotted-newts
#13
Andrea S Aspbury, Kristine L Grayson, Selamawit Fantaye, Ian Nichols, Miranda Myers-Burton, Xavier Ortiz-Mangual, Caitlin R Gabor
In populations with a male-biased operational sex ratio, coercive mating by males can have fitness consequences for females. One component of reduced fitness for females in populations with a male-biased OSR may be greater activation of the stress response, resulting in higher corticosterone release rates (CORT; a glucocorticoid stress hormone in amphibians). We test the hypothesis that a male-biased sex ratio affects female activity and release rates of CORT and testosterone (T) in male and female red-spotted newts (Notophthalmus viridescens)...
February 3, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28166967/embryonic-development-of-the-grass-pufferfish-takifugu-niphobles-from-egg-to-larvae
#14
V Gallego, M Yoshida, D Kurokawa, J F Asturiano, G J Fraser
Tetraodontidae (pufferfish) family members carry the smallest genomes among vertebrates, and these pocket-sized genomes have directly contributed to our understanding of the structure and evolution of higher animals. The grass pufferfish (Takifugu niphobles) could be considered a potential new model organism for comparative genomics and development due to the potential access to embryos, and availability of sequence data for two similar genomes: that of spotted green pufferfish (Tetraodon nigroviridis) and Fugu (Takifugu rubripes)...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28164667/albuminuria-is-suggested-as-a-potential-health-screening-biomarker-for-senior-citizens-and-general-population-with-hypertension-or-diabetes-in-china
#15
Dongmei Gu, Pengcheng Xu, Yuhua Yuan, Hongwei Fu
BACKGROUND: To evaluate the possibility of albuminuria as a screening biomarker for seniors or general population with hypertension and diabetes. METHODS: 478 health check-up individuals were enrolled. Albumin to creatinine ratio (ACR) was calculated by testing urinary albumin and creatinine of spot urine sample. Each urine sample was also analyzed by the routine urine test in parallel with ACR. Potential risk factors associated with the presence of albuminuria were analyzed using independent t-test or chi-square test...
November 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28161147/factors-associated-with-worsening-proliferative-diabetic-retinopathy-in-eyes-treated-with-panretinal-photocoagulation-or-ranibizumab
#16
Susan B Bressler, Wesley T Beaulieu, Adam R Glassman, Jeffrey G Gross, Lee M Jampol, Michele Melia, Mark A Peters, Michael E Rauser
PURPOSE: To compare rates and identify predictive factors for events that represent worsening of proliferative diabetic retinopathy (PDR) in eyes treated with panretinal photocoagulation (PRP) or ranibizumab. DESIGN: Randomized clinical trial (55 United States sites). PARTICIPANTS: Three hundred ninety-four study eyes from 305 adults with PDR, visual acuity (VA) 20/320 or better, and no history of PRP. INTERVENTION: Panretinal photocoagulation or intravitreous ranibizumab injections (0...
February 1, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28159785/identification-of-peptidoglycan-hydrolase-constructs-with-synergistic-staphylolytic-activity-in-cow-milk
#17
Carolin T Verbree, Steven M Dätwyler, Susanne Meile, Fritz Eichenseher, David M Donovan, Martin J Loessner, Mathias Schmelcher
: Peptidoglycan hydrolases (PGH) have been suggested as novel therapeutics for the treatment of bovine mastitis. However, activity in the presence of cow milk is an important requirement for drugs administered into the bovine udder. We have screened a library of >170 recombinant PGHs, including engineered bacteriophage endolysins, for enzymes with activity against Staphylococcus aureus in milk, using a microtiter plate-based protocol. Nine suitable PGH constructs were identified by this approach and further compared in time-kill assays for their efficacy against S...
February 3, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28151704/urinary-melatonin-in-relation-to-postmenopausal-breast-cancer-risk-according-to-melatonin-1-receptor-status
#18
Elizabeth E Devore, Erica T Warner, Heather Eliassen, Susan B Brown, Andrew H Beck, Susan Hankinson, Eva Schernhammer
BACKGROUND: Urinary melatonin levels have been associated with a reduced risk of breast cancer in postmenopausal women, but this association might vary according to tumor melatonin 1 receptor (MT1R) expression. METHODS: We conducted a nested case-control study among 1,354 postmenopausal women in the Nurses' Health Study, who were cancer free when they provided first-morning spot urine samples in 2000-2002; urine samples were assayed for 6-sulfatoxymelatonin (aMT6s, a major metabolite of melatonin)...
November 9, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28147672/distance-magnetic-nanoparticle-detection-using-a-magnetoelectric-sensor-for-clinical-interventions
#19
D T Huong Giang, D X Dang, N X Toan, N V Tuan, A T Phung, N H Duc
Distance magnetic nanoparticle detections were investigated by using a magnetoelectric based magnetic sensor with a long type bilayer Metglas/PZT laminate composite. In homogeneous magnetic fields, the sensor exhibits a sensitivity of 307.4 mV/Oe, which is possible for a detection limit of 2.7 × 10(-7) emu. This sensor can detect an amount of 0.31 μg of the superparamagnetic Fe3O4-chitosan fluid at 2 mm height above the sensor surface. To detect a spot with magnetic nanoparticles at a distance of about 7...
January 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28147670/a-facility-for-the-analysis-of-the-electronic-structures-of-solids-and-their-surfaces-by-synchrotron-radiation-photoelectron-spectroscopy
#20
M Hoesch, T K Kim, P Dudin, H Wang, S Scott, P Harris, S Patel, M Matthews, D Hawkins, S G Alcock, T Richter, J J Mudd, M Basham, L Pratt, P Leicester, E C Longhi, A Tamai, F Baumberger
A synchrotron radiation beamline in the photon energy range of 18-240 eV and an electron spectroscopy end station have been constructed at the 3 GeV Diamond Light Source storage ring. The instrument features a variable polarisation undulator, a high resolution monochromator, a re-focussing system to form a beam spot of 50 × 50 μm(2), and an end station for angle-resolved photoelectron spectroscopy (ARPES) including a 6-degrees-of-freedom cryogenic sample manipulator. The beamline design and its performance allow for a highly productive and precise use of the ARPES technique at an energy resolution of 10-15 meV for fast k-space mapping studies with a photon flux up to 2 ⋅ 10(13) ph/s and well below 3 meV for high resolution spectra...
January 2017: Review of Scientific Instruments
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