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https://www.readbyqxmd.com/read/29035737/rethinking-liquid-biopsy-microfluidic-assays-for-mobile-tumor-cells-in-human-body-fluids
#1
REVIEW
Kuang Hong Neoh, Ayon Ahmed Hassan, Anqi Chen, Yukun Sun, Peng Liu, Kai-Feng Xu, Alice S T Wong, Ray P S Han
Traditionally, liquid biopsy is a blood test involving the harvesting of tumor materials from peripheral blood. Tumor cells from non-blood body fluids have always been clinically available in cytological examinations but limited for use in differential diagnosis due to the low sensitivity of conventional cytopathology. With the recent significant progress in microfluidic and downstream molecular technologies, liquid biopsies have now evolved to include harvesting tumor cells and DNA fragments in all kinds of non-blood body fluids...
October 3, 2017: Biomaterials
https://www.readbyqxmd.com/read/29035107/maternal-social-disadvantage-and-newborn-telomere-length-in-archived-dried-blood-spots-from-the-michigan-neonatal-biobank
#2
Belinda L Needham, Margaret T Hicken, Ishtar O Govia, Colter Mitchell, Cleopatra M Abdou
Telomeres are the protective caps at the ends of eukaryotic chromosomes. Short telomere length is associated with morbidity and mortality among adults and may mark the biological impact of social experiences. Using archived dried blood spots from the Michigan Neonatal Biobank, this study examined markers of maternal social disadvantage (educational attainment, receipt of public assistance, marital status, and race/ethnicity) from linked birth certificates as predictors of telomere length at birth in a sample of 192 singleton neonates born to non-Hispanic black, non-Hispanic white, and Latina mothers aged 20-35 years...
2017: Biodemography and Social Biology
https://www.readbyqxmd.com/read/29032899/th1-epitope-peptides-induce-protective-immunity-against-rickettsia-rickettsii-infection-in-c3h-hen-mice
#3
Wenping Gong, Xiaolu Xiong, Pengcheng Wang, Jun Jiao, Xiaomei Yang, Bohai Wen
Rickettsia rickettsii is the causative pathogen of Rocky Mountain spotted fever (RMSF). Adr2, YbgF and OmpB are protective antigens of R. rickettsii. In this study, 90 candidate peptides were selected from these antigens based on their high-affinity binding capacity for the MHC class II molecule H2 I-A or H2 I-E using bioinformatic methods. Six peptides were determined using ELISPOT assay to be immunodominant based on the IFN-γ recall responses of CD4(+) T cells from mice immunized with R. rickettsii. Six nucleotide sequences encoding the immunodominant peptides were linked in series and inserted into a plasmid for expression in Escherichia coli cells, resulting in a new, recombinant polypeptide termed GWP...
October 9, 2017: Vaccine
https://www.readbyqxmd.com/read/29032039/the-efficacy-of-poly-%C3%AE-hydroxy-butyrate-phb-biosurfactant-derived-from-staphylococcus-hominis-against-white-spot-syndrome-virus-wssv-in-penaeus-monodon
#4
M Monica, T Priyanka, Akshaya Murugesan, V Rajeswari, Sivakumar Lingappa, S T Somasundaram, R Shenbhagarathai
White Spot Syndrome Virus (WSSV) is one of the most important causative agents of Penaeid shrimps diseases that incur heavy losses to the shrimp aquaculture. It has severe impact on the sustainability and the production of Penaeus monodon. Hence, the present study focussed on the investigation of Poly-β-hydroxybutyrate/biosurfactant as immunostimulants against WSSV infected shrimps. Infection of WSSV was periodically checked in all the experimental shrimps using PCR diagnostic kit. After ensuring all shrimps were free of viral infection, experiments were carried out to analyze the nonspecific immune responses (prophenol oxidase, nitro blue tetrazolium reduction assay and total haemocyte count) both in control and experimental group...
October 11, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29030958/association-of-meox2-polymorphism-with-nonsyndromic-cleft-palate-only-in-a-vietnamese-population
#5
Duy Le Tran, Hideto Imura, Akihiro Mori, Satoshi Suzuki, Teruyuki Niimi, Maya Ono, Chisato Sakuma, Shinichi Nakahara, Tham Thi Hong Nguyen, Phuong Thi Pham, Viet Hoang, Van Thi Tuyet Tran, Minh Duc Nguyen, Nagato Natsume
To evaluate the association between the single nucleotide polymorphism (SNP) rs227493 in the MEOX2 gene and nonsyndromic cleft palate only, this research was conducted as a case-control study by comparing a nonsyndromic cleft palate only group with an independent, healthy, and unaffected control group who were both examined by specialists. Based on clinical examination and medical records, we analyzed a total of 570 DNA samples, including 277 cases and 293 controls, which were extracted from dry blood spot samples collected from both the Odonto and Maxillofacial Hospital in Ho Chi Minh City and Nguyen Dinh Chieu Hospital in Ben Tre province respectively...
October 14, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/29029248/efficacy-of-nanoencapsulated-thymus-eriocalyx-and-thymus-kotschyanus-essential-oils-by-a-mesoporous-material-mcm-41-against-tetranychus-urticae-acari-tetranychidae
#6
Asgar Ebadollahi, Jalal Jalali Sendi, Alireza Aliakbar
Inspite of well-established potentiality of plant essential oils as biopesticides, their environmentally low persistence is considered as a hindering obstacle for its commercialization. In the present study, chemical composition and toxicity of essential oils isolated from leaves of Thymus eriocalyx and Thymus kotschyanus were evaluated against two-spotted spider mite, Tetranychus urticae. The chemicals present in the crude oil were found to be thymol (28.83%), oleic acid (11.51%), palmitic acid (8.60%), borneol (5...
September 27, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29023010/bio-controlling-effect-of-leaf-extract-of-tagetes-patula-l-marigold-on-growth-parameters-and-diseases-of-tomato
#7
Gayatri Nahak, Rajani Kanta Sahu
BACKGROUND: The genus Tagetes (Asteraceae) is native to Americas but some of its members (in particular T. erecta and T. patula) commonly known as marigolds were naturalized in the old world (India, North Africa and Europe) as early as in 16th century. The flowers of French marigold (Tagetes patula L.) are widely used in folk medicine, in particular for treating inflammation-related disorders. MATERIALS AND METHODS: This study investigated the potential use of marigold (Tagetes patula L...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29018418/microbial-diversity-in-a-hypersaline-sulfate-lake-a-terrestrial-analog-of-ancient-mars
#8
Alexandra Pontefract, Ting F Zhu, Virginia K Walker, Holli Hepburn, Clarissa Lui, Maria T Zuber, Gary Ruvkun, Christopher E Carr
Life can persist under severe osmotic stress and low water activity in hypersaline environments. On Mars, evidence for the past presence of saline bodies of water is prevalent and resulted in the widespread deposition of sulfate and chloride salts. Here we investigate Spotted Lake (British Columbia, Canada), a hypersaline lake with extreme (>3 M) levels of sulfate salts as an exemplar of the conditions thought to be associated with ancient Mars. We provide the first characterization of microbial structure in Spotted Lake sediments through metagenomic sequencing, and report a bacteria-dominated community with abundant Proteobacteria, Firmicutes, and Bacteroidetes, as well as diverse extremophiles...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29016879/agonist-ox40-immunotherapy-improves-survival-in-glioma-bearing-mice-and-is-complementary-with-vaccination-with-irradiated-gm-csf-expressing-tumor-cells
#9
Nusrat Jahan, Hammad Talat, William T Curry
Background: Glioma immunotherapy is an active area of clinical investigation. Glioma-associated immunosuppression remains an obstacle to efficacious immunotherapy, and combination approaches are likely necessary for durable success. OX40 is a member of the tumor necrosis factor receptor superfamily that is upregulated on activated lymphocytes, ligation of which results in enhanced activity and may be active against cancer. We sought to confirm the efficacy of agonist anti-OX40 immunotherapy against glioma and hypothesized that it is complementary with irradiated whole tumor cell vaccination...
July 7, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28993676/properties-analysis-of-transcription-factor-gene-tasmyb36-from-trichoderma-asperellum-cbs433-97-and-its-heterogeneous-transfomation-to-improve-antifungal-ability-of-populus
#10
Shida Ji, Zhiying Wang, Jinjie Wang, Haijuan Fan, Yucheng Wang, Zhihua Liu
The transcription of TasMYB36 in the biocontrol species T. asperellum was upregulated in four different pathogenic fermentation broths, suggesting that TasMYB36 plays an important role in the response to biotic stresses. Seventy-nine MYB transcription factors that were homologous to TasMYB36 from six sequenced Trichoderma genomes were analyzed. They were distributed in fourteen clades in the phylogenetic tree. The 79 MYBs contained 113 DNA binding domains, and their amino acid sequences were conserved and were different to those in plants...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28992302/northern-spotted-owl-strix-occidentalis-caurina-genome-divergence-with-the-barred-owl-strix-varia-and-characterization-of-light-associated-genes
#11
Zachary R Hanna, James B Henderson, Jeffrey D Wall, Christopher A Emerling, Jérôme Fuchs, Charles Runckel, David P Mindell, Rauri C K Bowie, Joseph L DeRisi, John P Dumbacher
We report here the assembly of a northern spotted owl (Strix occidentalis caurina) genome. We generated Illumina paired-end sequence data at 90× coverage using nine libraries with insert lengths ranging from ∼250 to 9,600 nt and read lengths from 100 to 375 nt. The genome assembly is comprised of 8,108 scaffolds totaling 1.26 × 109 nt in length with an N50 length of 3.98 × 106 nt. We calculated the genome-wide fixation index (FST) of S. o. caurina with the closely related barred owl (Strix varia) as 0...
October 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28990181/long-term-impairment-attributable-to-congenital-cytomegalovirus-infection-a-retrospective-cohort-study
#12
Marjolein J Korndewal, Anne Marie Oudesluys-Murphy, Aloys C M Kroes, Marianne A B van der Sande, Hester E de Melker, Ann C T M Vossen
AIM: This study aimed to estimate long-term impairment attributable to congenital cytomegalovirus infection (cCMV). METHOD: This nationwide cohort study retrospectively assessed cCMV in children born in 2008 in the Netherlands, testing 31 484 stored neonatal dried blood spots. Extensive medical data of cCMV-positive children (n=133) and matched cCMV-negative comparison children (n=274) up to 6 years of age were analysed. RESULTS: Moderate to severe long-term impairment was diagnosed in 24...
October 9, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28987439/evaluation-of-t-and-b-memory-cell-responses-elicited-by-the-pandemic-h1n1-vaccine-in-hiv-infected-and-hiv-uninfected-individuals
#13
Peifang Sun, Nancy F Crum-Cianflone, Gabriel Defang, Maya Williams, Anuradha Ganesan, Brian K Agan, Tahaniyat Lalani, Timothy Whitman, Carolyn Brandt, Timothy H Burgess
BACKGROUND: This study was to compare B and T memory cells elicited by a single dose monovalent 2009 influenza A (H1N1) vaccine (strain A/California/7/2009 H1N1) in HIV(+) and HIV(-) groups, and to analyze the impact of the prior seasonal vaccines to the immunogenicity of this vaccine. METHODS: Blood samples were collected before vaccination (day 0) and at days 28 and 180. Participants were categorized into HIV(-)/LAIV, HIV(-)/TIV and HIV(+)/TIV subgroups according to the trivalent live-attenuated or inactivated (LAIV or TIV) seasonal influenza vaccines they received previously...
October 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28981923/-mutation-analysis-for-a-pedigree-affected-with-keratitis-ichthyosis-deafness-syndrome
#14
Lulu Li, Yuan Li, Wei Lin, Xiuli Zhao
OBJECTIVE: To identify mutation of GJB2 gene and provide genetic counseling for a family affected with keratitis-ichthyosis-deafness (KID) syndrome. METHODS: Genomic DNA was extracted from peripheral blood samples with a standard phenol-chloroform method. PCR and Sanger sequencing were used to analyze potential mutation in the proband. Suspected mutation was verified with a PCR-high-resolution melting (PCR-HRM) method. T-clone sequencing was applied to determine the parental origin of the mutation...
October 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28981669/role-of-fly-cleaning-behavior-on-carriage-of-escherichia-coli-and-pseudomonas-aeruginosa
#15
B J Jacques, T J Bourret, J J Shaffer
Flies are known to be mechanical vectors of bacterial, viral, and parasitic diseases. Although flies are known to transmit disease, the effects of cleaning behavior have not been well studied. This study quantified the cleaning effectiveness and behavior of three fly species: Sarcophaga bullata, Musca domestica L., and Drosophila virilis. Flies were transferred to plates of Escherichia coli or Pseudomonas aeruginosa and allowed to walk on the bacteria for a total of 5 min. After the flies were contaminated, they were either immediately collected to quantify bacteria or were placed onto sterile plates to clean for 5 or 10 min...
July 14, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28979271/a-streamlined-approach-by-a-combination-of-bioindication-and-geostatistical-methods-for-assessing-air-contaminants-and-their-effects-on-human-health-in-industrialized-areas-a-case-study-in-southern-brazil
#16
Angélica B Ferreira, Andreza P Ribeiro, Maurício L Ferreira, Cláudia T Kniess, Cristiano C Quaresma, Raffaele Lafortezza, José O Santos, Mitiko Saiki, Paulo H Saldiva
Industrialization in developing countries associated with urban growth results in a number of economic benefits, especially in small or medium-sized cities, but leads to a number of environmental and public health consequences. This problem is further aggravated when adequate infrastructure is lacking to monitor the environmental impacts left by industries and refineries. In this study, a new protocol was designed combining biomonitoring and geostatistics to evaluate the possible effects of shale industry emissions on human health and wellbeing...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28973721/genetic-diversity-of-arboreal-cotton-populations-of-the-brazilian-semiarid-a-remnant-primary-gene-pool-for-cotton-cultivars
#17
I P P de Menezes, L V Hoffmann, T H de Lima, A R da Silva, V S Lucena, P A V Barroso
Mocó cotton belong to the same species as the cultivated species, Gossypium hirsutum, and cultivated forms were mainly landraces but also developed as cultivars, bearing good fiber quality and drought tolerant when cropped as a perennial species. The northeast Brazil crop system based on this cotton type is finished, with a few small area planted in the three main States, where it was previously cultivated (Ceará, Paraíba, and Rio Grande do Norte), but in others, maintenance is accomplished by single dooryard plants...
September 27, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28969780/experimental-transmission-of-toxocara-canis-from-blattella-germanica-and-periplaneta-americana-cockroaches-to-a-paratenic-host
#18
T González-García, M A Muñoz-Guzmán, H Sánchez-Arroyo, M G Prado-Ochoa, J A Cuéllar-Ordaz, F Alba-Hurtado
The present study assessed the capacity of Blattella germanica and Periplaneta americana to disseminate and transmit infective phases of T. canis to rats, which were used as a model paratenic host. P. americana and B. germanica inoculated orally with T. canis larvated eggs shed eggs and larvae in their fecal matter during the first 6days post-inoculation. Larvae were recovered from the brain, lungs, kidneys and liver of rats that had been inoculated with either infected cockroaches or their feces. ELISAs of serum detected an increase of antibodies anti-T...
November 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28969132/prognostic-significance-of-epidermal-growth-factor-receptor-in-patients-of-glioblastoma-multiforme
#19
Kalpalata Tripathy, Bidyutprava Das, Ajit Kumar Singh, Aparajita Misra, Sanjib Misra, Sudhansu Sekhar Misra
INTRODUCTION: Glioblastoma Multiforme (GBM) is the most aggressive glial tumour with hallmark characteristics of rampant proliferation of glial cells along with high pleomorphism, necrosis, endothelial proliferation and high MIB-1 labeling index (cell proliferation marker). These tumours are managed by surgery followed by Radiotherapy (RT), Chemotherapy (CT) and adjuvant CT Temozolomide (TMZ). AIM: To evaluate Epidermal Growth Factor Receptor (EGFR) protein expression in GBM patients...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28967977/nail-involvement-in-alopecia-areata-a-questionnaire-based-survey-of-impact-on-quality-of-life-and-review-of-the-literature
#20
Yvonne B M Roest, Henrià T van Middendorp, Andrea W M Evers, Peter C M van de Kerkhof, Marcel C Pasch
Alopecia areata (AA) is an immune-mediated disease causing temporary or permanent hair loss. Up to 46% of patients with AA also have nail involvement. The aim of this study was to determine the presence, types, and clinical implications of nail changes in patients with AA. This questionnaire-based survey evaluated 256 patients with AA. General demographic variables, specific nail changes, nail-related quality of life (QoL), and treatment history and need were evaluated. Prevalence of nail involvement in AA was 64...
October 2, 2017: Acta Dermato-venereologica
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