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https://www.readbyqxmd.com/read/28227749/reconstructing-multivariate-causal-structure-between-functional-brain-networks-through-a-laguerre-volterra-based-granger-causality-approach
#1
Andrea Duggento, Gaetano Valenza, Luca Passamonti, Maria Guerrisi, Riccardo Barbieri, Nicola Toschi, Andrea Duggento, Gaetano Valenza, Luca Passamonti, Maria Guerrisi, Riccardo Barbieri, Nicola Toschi, Andrea Duggento, Nicola Toschi, Maria Guerrisi, Luca Passamonti, Riccardo Barbieri, Gaetano Valenza
Classical multivariate approaches based on Granger causality (GC) which estimate functional connectivity in the brain are almost exclusively based on autoregressive models. Nevertheless, information available from past samples is limited due to both signal autocorrelation and necessarily low model orders. Consequently, multiple time-scales interactions are usually unaccounted for. To overcome these limitations, in this study we propose the use of discrete-time orthogonal Laguerre basis functions within a Wiener-Volterra decomposition of the BOLD signals to perform effective GC assessments of brain functional connectivity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226831/muscle-synergy-analysis-in-transtibial-amputee-during-ramp-ascending-activity
#2
P Mehryar, M S Shourijeh, H F Maqbool, M Torabi, A A Dehghani-Sanij, P Mehryar, M S Shourijeh, H F Maqbool, M Torabi, A A Dehghani-Sanij, A A Dehghani-Sanij, M S Shourijeh, P Mehryar, M Torabi, H F Maqbool
In developed countries, the highest number of amputees are elderly with transtibial amputation. Walking on inclined surfaces is difficult for amputees due to loss of muscle volume and strength thereby transtibial amputees (TA) rely on the intact limb to maintain stability. The aim of this study was to use the concatenated non-negative matrix factorization (CNMF) technique to calculate muscle synergy components and compare the difference in muscle synergies and their associated activation profiles in the healthy and amputee groups during ramp ascending (RA) activity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226600/analysis-of-magnetoencephalography-signals-from-alzheimer-s-disease-patients-using-granger-causality
#3
Celia Juan-Cruz, Carlos Gomez, Jesus Poza, Alberto Fernandez, Roberto Hornero, Celia Juan-Cruz, Carlos Gomez, Jesus Poza, Alberto Fernandez, Roberto Hornero, Roberto Hornero, Celia Juan-Cruz, Carlos Gomez, Jesus Poza, Alberto Fernandez
The aim of this study was to analyze resting-state magnetoencephalography (MEG) activity in Alzheimer's disease (AD) by means of Granger Causality (GC), an effective connectivity measure that provides an estimation of the information flow between brain regions. For this task, five minutes of MEG recordings were acquired with a 148-channel whole-head magnetometer from 36 AD patients and 26 healthy controls. Abnormalities in AD connectivity were found in the five typical frequency bands: delta (δ, 1-4 Hz), theta (θ, 4-8 Hz), alpha (α, 8-13 Hz), beta (β, 13-30 Hz), and gamma (γ, 30-65 Hz)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226360/-research-progress-of-peripheral-blood-count-test-in-the-evaluation-of-prognosis-of-gastric-cancer
#4
Zhengshui Xu, Hua Cheng
Gastric cancer (GC) is one of the most common tumor in the world, and remains a major public health problem and one of the leading causes of death. Recently many researches have demonstrated that systemic inflammatory response is associated with prognosis and response to therapy in gastric cancer, and the peripheral blood count test can partly reflect the systemic inflammatory response. Based on the peripheral blood count test, there are a lot of research regarding the relation between the platelet count (PLT), neutrophil, lymphocyte, white blood cell (WBC), neutrophil to lymphocyte ratio(NLR), platelet to lymphocyte ratio (PLR) with their prognostic role in gastric cancer...
February 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28226330/nutritional-recovery-after-open-and-laparoscopic-distal-gastrectomy-for-early-gastric-cancer-a-prospective-multicenter-comparative-trial-ccog1204
#5
Hidenobu Matsushita, Chie Tanaka, Kenta Murotani, Kazunari Misawa, Seiji Ito, Yuichi Ito, Mitsuro Kanda, Yoshinari Mochizuki, Kiyoshi Ishigure, Toyohisa Yaguchi, Jin Teramoto, Hiroshi Nakayama, Yoshihisa Kawase, Michitaka Fujiwara, Yasuhiro Kodera
BACKGROUND: Little information from prospective clinical trials is available on the influences of surgical approaches on postoperative body compositions and nutritional status. We designed a prospective non-randomized trial to compare postoperative chronological changes in body composition and nutritional status between laparoscopic and open distal gastrectomy for stage I gastric cancer (GC). METHODS: Body compositions and nutritional indicators in blood tests were measured at the baseline and at the 1st, 3rd, 6th, and 12th postoperative months (POM)...
February 23, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28226066/chlamydia-trachomatis-infection-in-young-pregnant-women-in-southern-brazil-a-cross-sectional-study
#6
Mariângela Freitas da Silveira, Iândora Krolow Timm Sclowitz, Ludmila Gonçalves Entiauspe, Marilia Arndt Mesenburg, Dulce Stauffert, Guilherme Lucas de Oliveira Bicca, Carine Pieniz, Adriane Brod Manta
This study estimated the prevalence of Chlamydia trachomatis infection during pregnancy in a sample of women up to 29 years of age in the city of Pelotas, Rio Grande do Sul State, Brazil, and investigated socio-demographic risk factors such as maternal age, marital status, maternal schooling, and family income. C. trachomatis infection was diagnosed with PCR using BD ProbeTecTM CT/GC Amplified DNA Assay. Socio-demographic, behavioral, and reproductive data were collected using structured questionnaires. All collections were performed by previously trained medical students...
February 13, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28225829/inhibition-of-arabidopsis-chloroplast-%C3%AE-amylase-bam3-by-maltotriose-suggests-a-mechanism-for-the-control-of-transitory-leaf-starch-mobilisation
#7
Jing Li, Wenxu Zhou, Perigio Francisco, Russell Wong, Dongke Zhang, Steven M Smith
Starch breakdown in leaves at night is tightly matched to the duration of the dark period, but the mechanism by which this regulation is achieved is unknown. In Arabidopsis chloroplasts, β-amylase BAM3 hydrolyses transitory starch, producing maltose and residual maltotriose. The aim of the current research was to investigate the regulatory and kinetic properties of BAM3. The BAM3 protein was expressed in Escherichia coli and first assayed using a model substrate. Enzyme activity was stimulated by treatment with dithiothreitol and was increased 40% by 2-10 μM Ca2+ but did not require Mg2+...
2017: PloS One
https://www.readbyqxmd.com/read/28225753/complement-drives-glucosylceramide-accumulation-and-tissue-inflammation-in-gaucher-disease
#8
Manoj K Pandey, Thomas A Burrow, Reena Rani, Lisa J Martin, David Witte, Kenneth D Setchell, Mary A Mckay, Albert F Magnusen, Wujuan Zhang, Benjamin Liou, Jörg Köhl, Gregory A Grabowski
Gaucher disease is caused by mutations in GBA1, which encodes the lysosomal enzyme glucocerebrosidase (GCase). GBA1 mutations drive extensive accumulation of glucosylceramide (GC) in multiple innate and adaptive immune cells in the spleen, liver, lung and bone marrow, often leading to chronic inflammation. The mechanisms that connect excess GC to tissue inflammation remain unknown. Here we show that activation of complement C5a and C5a receptor 1 (C5aR1) controls GC accumulation and the inflammatory response in experimental and clinical Gaucher disease...
February 22, 2017: Nature
https://www.readbyqxmd.com/read/28225553/correlations-among-mercury-concentration-and-stable-isotope-ratios-of-carbon-and-nitrogen-of-amino-acids-in-scalp-hair-from-whale-meat-eaters-and-heavy-fish-eaters
#9
Tetsuya Endo, Hideki Ogasawara, Moriaki Hayasaka, Yohei Hotta, Osamu Kimura, Klaus J Petzke
RATIONALE: As Hg accumulation in marine animals generally increases with increased trophic level (δ(15) N values) through the food web, predators accumulate higher levels of Hg. The main source of human Hg intake is the consumption of fish and other marine animals, and Hg concentration in scalp hair is the preferred marker for evaluating consumption of marine animals. Difference of δ(15) N values between trophic and source amino acids of human consumers could enable us to estimate the trophic level of consumer without knowing the bulk δ(15) N value of their prey...
February 22, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28225098/urinary-metabolic-signatures-and-early-triage-of-acute-radiation-exposure-in-rat-model
#10
Mingxiao Zhao, Kim Kt Lau, Xian Zhou, Jianfang Wu, Jun Yang, Chang Wang
After a large-scale radiological accident, early-response biomarkers to assess radiation exposure over a broad dose range are not only the basis of rapid radiation triage, but are also the key to the rational use of limited medical resources and to the improvement of treatment efficiency. Because of its high throughput, rapid assays and minimally invasive sample collection, metabolomics has been applied to research into radiation exposure biomarkers in recent years. Due to the complexity of radiobiological effects, most of the potential biomarkers are both dose-dependent and time-dependent...
February 22, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28225058/superstatistical-model-of-bacterial-dna-architecture
#11
Mikhail I Bogachev, Oleg A Markelov, Airat R Kayumov, Armin Bunde
Understanding the physical principles that govern the complex DNA structural organization as well as its mechanical and thermodynamical properties is essential for the advancement in both life sciences and genetic engineering. Recently we have discovered that the complex DNA organization is explicitly reflected in the arrangement of nucleotides depicted by the universal power law tailed internucleotide interval distribution that is valid for complete genomes of various prokaryotic and eukaryotic organisms. Here we suggest a superstatistical model that represents a long DNA molecule by a series of consecutive ~150 bp DNA segments with the alternation of the local nucleotide composition between segments exhibiting long-range correlations...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224911/determination-of-total-cyanide-in-soil-by-isotope-dilution-gc-ms-following-pentafluorobenzyl-derivatization
#12
Beatrice Campanella, Lorenzo Biancalana, Lucia D'Ulivo, Massimo Onor, Emilia Bramanti, Zoltan Mester, Enea Pagliano
The high toxicity of cyanide, along with its widespread industrial use, has fuelled interest in the development of analytical methods for its determination in complex matrices. In this study, we propose a novel approach for the measurement of total cyanide in soil samples based on single-step derivatization with pentafluorobenzyl bromide (F5Bn-Br) followed by quantitation with gas chromatography mass spectrometry in negative chemical ionization mode. The reaction between CN(-) and F5Bn-Br resulted in the identification of several derivatives such as F5Bn-CN, (F5Bn)(F5Ph)CH-CN, and (F5Bn)2(F5Ph)C-CN...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224910/identification-of-sink-spots-in-two-thermal-desorption-gc-ms-systems-for-the-analysis-of-polycyclic-aromatic-hydrocarbons
#13
Yingjie Li, Jiping Zhu
Thermal desorption (TD) GC/MS has been used for the analysis of polycyclic aromatic hydrocarbons (PAHs) and other semi-volatile organic compounds. However, thermal desorption recovery of PAHs have not been well studied and the cause of PAH residues in a TD system has not been clearly understood. Our results showed that low volatility of PAHs can lead to their incomplete recovery in a TD system: for the PAHs with low vapour pressures, up to 10% and 3% could be lost in a two-stage (TS) TD system and a short-path (SP) TD system, respectively...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224907/multi-block-data-analysis-using-comdim-for-the-evaluation-of-complex-samples-characterization-of-edible-oils
#14
Larissa Naida Rosa, Luana Caroline de Figueiredo, Elton Guntendorfer Bonafé, Aline Coqueiro, Jesuí Vergílio Visentainer, Paulo Henrique Março, Douglas N Rutledge, Patrícia Valderrama
The ComDim chemometrics method for multi-block analysis was employed to evaluate thirty-two vegetable oil samples analyzed by near infrared (NIR) and ultraviolet-visible (UV-Vis) spectroscopy, and by Gas Chromatography with flame ionization detection (GC-FID) for their fatty acids composition. This unsupervised pattern recognition method was able to extract information from the tables of results that could be presented in informative graphs showing the relationship between the samples through the scores, the predominance of information in particular tables through the saliences and the contribution of the variables in each table which were responsible for the similarities observed in the samples, through the loadings plots...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224894/development-of-drug-delivery-systems-for-taxanes-using-ionic-gelation-of-carboxyacyl-derivatives-of-chitosan
#15
Yury A Skorik, Anton A Golyshev, Andreii S Kritchenkov, Ekaterina R Gasilova, Daria N Poshina, Amal J Sivaram, Rangasamy Jayakumar
Nanoparticles of two chitosan derivatives - N-succinyl-chitosan (SC) and N-glutaryl-chitosan (GC) - were developed as passive transport systems for taxanes (paclitaxel and docetaxel) using an ionic gelation technique with sodium tripolyphosphate. These nanoparticles had an apparent hydrodynamic diameter of 300-350nm, a ζ-potential of 25-31mV, an encapsulation efficiency of 21-26%, and a drug loading efficiency of 6-13%. DLS and SLS analysis shows that the nanoparticles have a unimodal size distribution and spherical form...
April 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28224723/synthetic-extreme-environments-overlooked-sources-of-potential-biotechnologically-relevant-microorganisms
#16
Timothy Sibanda, Ramganesh Selvarajan, Memory Tekere
Synthetic extreme environments like carwash effluent tanks and drains are potential sources of biotechnologically important microorganisms and molecules which have, however, remained unexplored. Using culture- and molecular-based methods, a total of 17 bacterial isolates belonging to the genera Shewanella, Proteus, Paenibacillus, Enterobacter and Citrobacter, Aeromonas, Pseudomonas and Pantoea were identified. Hydrocarbon utilization and enzyme production screening assays showed that Aeromonas sp. CAC11, Paenibacillus sp...
February 22, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28224464/laparoscopic-gastrojejunostomy-for-patients-with-unresectable-gastric-cancer-with-gastric-outlet-obstruction
#17
Toshiyasu Ojima, Mikihito Nakamori, Masaki Nakamura, Masahiro Katsuda, Keiji Hayata, Hiroki Yamaue
BACKGROUND: There have been no comparative studies of open gastrojejunostomy (OGJ) and laparoscopic gastrojejunostomy (LGJ) in gastric cancer (GC) patients with gastric outlet obstruction (GOO) to explore both short- and long-term outcomes. The aim of this study was to compare the safety and feasibility of short-term oral intake as well as the long-term oncological outcome of OGJ and LGJ. METHODS: This was a retrospective study of 53 consecutive unresectable GC patients who underwent GJ for GOO in our institute...
February 21, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28224423/prognostic-significance-of-autophagy-related-proteins-expression-in-resected-human-gastric-adenocarcinoma
#18
Bing Qu, Lei Yao, Hua-Ling Ma, Hong-Lei Chen, Zhi Zhang, Jiang Xie
Gastric adenocarcinoma (GC) is one of the most common malignancies in the world and one of the most frequent causes of cancer-related death. Autophagy is a highly regulated catabolic pathway responsible for the degradation of long-lived proteins and damaged intracellular organelles. However, the mechanism and guiding significance of autophagy in the development and progression of GC have remained to be elucidated. This study aimed to explore the clinicopathological significances and prognostic values of autophagy-related proteins AMBRA1 and Beclin-1 in GC...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28224294/cardio-metabolic-risk-factors-in-youth-with-classical-21-hydroxylase-deficiency
#19
Kansuda Ariyawatkul, Supatporn Tepmongkol, Suphab Aroonparkmongkol, Taninee Sahakitrungruang
: Patients with congenital adrenal hyperplasia (CAH) appear to have adverse cardiovascular risk profile and other long-term health problems in adult life, but there are limited data in young CAH patients. We aim to evaluate the cardio-metabolic risk factors in adolescents and young adults with classical 21-hydroxylase deficiency (21-OHD). We performed a cross-sectional study of 21 patients (17 females) with classic CAH detected clinically and not through newborn screening, aged 15.2 ± 5...
February 21, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28224154/unexpectedly-high-concentrations-of-monoterpenes-in-a-study-of-uk-homes
#20
Chunting Michelle Wang, Benjamin Barratt, Nicola Carslaw, Artemis Doutsi, Rachel E Dunmore, Martyn W Ward, Alastair C Lewis
The abundance of volatile organic compounds (VOCs) found in homes depends on many factors such as emissions, ventilation and the oxidative environment and these are evolving over time, reflecting changes in chemical use, behaviour and building design/materials. The concentrations of VOCs in 25 UK homes of varying ages, design and occupancy were quantified using continuous indoor air sampling over five days. Air was collected through low flow (1 mL min(-1)) constant flow restrictors into evacuated 6 L internally silica-treated canisters until the canisters reached atmospheric pressure...
February 22, 2017: Environmental Science. Processes & Impacts
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