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https://www.readbyqxmd.com/read/29166615/olfactory-experience-and-developmental-stage-dependent-control-of-cpeb4-regulates-c-fos-mrna-translation-for-granule-cell-survival
#1
Ching-San Tseng, Hsu-Wen Chao, Hsien-Sung Huang, Yi-Shuian Huang
Mammalian olfactory bulbs (OBs) require continuous replenishment of interneurons (mainly granule cells [GCs]) to support local circuits throughout life. Two spatiotemporally distinct waves of postnatal neurogenesis contribute to expanding and maintaining the GC pool. Although neonate-born GCs have a higher survival rate than adult-born GCs, the molecular mechanism underlying this survival remains unclear. Here, we find that cytoplasmic polyadenylation element-binding protein 4 (CPEB4) acts as a survival factor exclusively for early postnatal GCs...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29165376/preparation-of-vitexin-nanoparticles-by-combining-the-antisolvent-precipitation-and-high-pressure-homogenization-approaches-followed-by-lyophilization-for-dissolution-rate-enhancement
#2
Chengbo Gu, Ziwei Liu, Xiaohan Yuan, Wang Li, Yuangang Zu, Yujie Fu
Vitexin, a natural flavonoid found in many medicinal plants, is well known for its rich pharmacological activities. However, the poor water solubility of vitexin has limited its therapeutic application. The aim of this study was to prepare the nanoparticles of vitexin by combining the antisolvent precipitation (ASP) and high pressure homogenization (HPH) approaches followed by lyophilization for improving the dissolution rate of this poorly water-soluble drug. The effects of main factors influencing the mean particle size (MPS) of vitexin were investigated and optimized...
November 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29164813/chemical-polymorphism-of-essential-oils-of-artemisia-vulgaris-growing-wild-in-lithuania
#3
Asta Judzentiene, Jurga Budiene
Compositional variability of mugwort (Artemisia vulgaris L.) essential oils has been investigated in the study. Plant material (over ground parts at full flowering stage) was collected from forty-four wild populations in Lithuania. The oils from aerial parts were obtained by hydrodistillation and analyzed by GC(FID) and GC/MS. In total, up to 111 components were determined in the oils. As the major constituents were found: sabinene, 1,8-cineole, artemisia ketone, both thujone isomers, camphor, cis-chrysanthenyl acetate, davanone and davanone B...
November 21, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29164812/inter-and-intraspecific-variability-of-nitrogenated-compounds-in-gorgonian-corals-via-application-of-a-fast-one-step-analytical-protocol
#4
Chiara Samorì, Federica Costantini, Paola Galletti, Emilio Tagliavini, Marco Abbiati
Gorgonian corals play a structural role in temperate and tropical biogenic reefs, forming animal forests and creating biodiversity hot spots. In the Mediterranean Sea, slow-growing and long-lived gorgonian species are threatened by human disturbances and global environmental changes and concern about their conservation is rising. Alkaloid metabolites have proven to be essential in protecting these species from environmental stressors.. Traditional profiling methodologies to detect these metabolites require a large quantity of living tissue...
November 21, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29164790/comparative-study-of-fatty-acids-profile-in-eleven-wild-mushrooms-of-boletacea-and-russulaceae-families
#5
Marija V Dimitrijevic, Violeta D Mitic, Olga P Jovanovic, Vesna P Stankov Jovanovic, Jelena S Nikolic, Goran M Petrovic, Gordana S Stojanovic
Eleven species of wild mushrooms which belong to Boletaceae and Russulaceae families were examined by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) analysis for the presence of fatty acids. As far as we know, the fatty acid profiles of B. purpureus and B. rhodoxanthus were described for the first time. Twenty-six fatty acids were determined. Linoleic (19.5 - 72%), oleic (0.11 - 64%), palmitic (5.9 - 22%) and stearic acids (0.81 - 57%) were present in the highest contents. In all samples, unsaturated fatty acids dominate...
November 21, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29164140/phenotypic-and-genotypic-features-of-a-salmonella-heidelberg-strain-isolated-in-broilers-in-brazil-and-their-possible-association-to-antibiotics-and-short-chain-organic-acids-resistance-and-susceptibility
#6
Elizabeth Santin, Ricardo Mitsuo Hayashi, Jessica Caroline Wammes, Ricardo Gonzalez-Esquerra, Marcelo Falsarella Carazzolle, Caio César de Melo Freire, Paulo Sérgio Monzani, Anderson Ferreira da Cunha
Salmonella enterica serovar Heidelberg is a human pathogen also found in broilers. A strain (UFPR1) has been associated with field reports of resistance to short-chain organic acids (SCOA) in broilers in the South of Brazil, but was susceptible to a Bacillus subtilis-based probiotic added in feed in a related study. This work aimed to (i) report clinical symptoms caused by SH UFPR1 in broilers, (ii) study its susceptibility to some antibiotics in vitro, and (iii) SCOA in vivo; and (iv) relate these phenotypic observations with its genome characteristics...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29164013/physician-adherence-to-sexually-transmitted-infection-screening-guidelines-in-an-ob-gyn-teaching-clinic-in-hawai-i
#7
Alyssa Dee P Carlson, Mary Tschann, Somsook Santibenchakul, Eric L Hurwitz, Jennifer Salcedo
Rates of chlamydia (CT) and gonorrhea (GC) have risen for the first time in the United States since 2006. Certain population groups are disproportionately affected by these sexually transmitted infections (STIs) as well as HIV. The Centers for Disease Control and Prevention (CDC) and professional societies have published screening guidelines for these STIs for women under the age of 25. We aimed to quantify physician adherence to GC/CT and HIV screening guidelines and to determine demographic factors associated with GC/CT and HIV screening recommendations among women 14-25 years old in Honolulu, Hawai'i...
November 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/29163810/myeloid-ecotropic-viral-integration-site-1-inhibits-cell-proliferation-invasion-or-migration-in-human-gastric-cancer
#8
Fei Song, Hong Wang, Yingying Wang
Myeloid ecotropic viral integration site 1 (MEIS1) has been identified to be a potential tumor suppressor in some cancers. However, the mechanisms underlying MEIS1-induced cancer development and progression were not clear. Here, we investigated the expression and role of MEIS1 in gastric cancer. In vivo, we analyzed tumor growth using nude mice model. In the present study, MEIS1 expression was obviously decreased in GC cell lines compared with that in normal gastric cell lines (all p<0.001). MEIS1 overexpression inhibited cell proliferation and G1/S transition accompanied by decreased Cyclin D1 and Cyclin A expression...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163617/phenylpropanoid-scent-compounds-in-petunia-x-hybrida-are-glycosylated-and-accumulate-in-vacuoles
#9
Alon Cna'ani, Reut Shavit, Jasmin Ravid, Javiera Aravena-Calvo, Oded Skaliter, Tania Masci, Alexander Vainstein
Floral scent has been studied extensively in the model plant Petunia. However, little is known about the intracellular fate of scent compounds. Here, we characterize the glycosylation of phenylpropanoid scent compounds in Petunia x hybrida. This modification reduces scent compounds' volatility, reactivity, and autotoxicity while increasing their water-solubility. Gas chromatography-mass spectrometry (GC-MS) analyses revealed that flowers of petunia cultivars accumulate substantial amounts of glycosylated scent compounds and that their increasing level parallels flower development...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29163507/impact-of-chronic-viral-infection-on-t-cell-dependent-humoral-immune-response
#10
REVIEW
Stéphane Rodriguez, Mikaël Roussel, Karin Tarte, Patricia Amé-Thomas
During the last decades, considerable efforts have been done to decipher mechanisms supported by microorganisms or viruses involved in the development, differentiation, and function of immune cells. Pathogens and their associated secretome as well as the continuous inflammation observed in chronic infection are shaping both innate and adaptive immunity. Secondary lymphoid organs are functional structures ensuring the mounting of adaptive immune response against microorganisms and viruses. Inside these organs, germinal centers (GCs) are the specialized sites where mature B-cell differentiation occurs leading to the release of high-affinity immunoglobulin (Ig)-secreting cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163465/b-cell-activating-factor-and-the-b-cell-compartment-in-hiv-siv-infection
#11
REVIEW
Gwenoline Borhis, Maria Trovato, Nada Chaoul, Hany M Ibrahim, Yolande Richard
With the goal to design effective HIV vaccines, intensive studies focused on broadly neutralizing antibodies, which arise in a fraction of HIV-infected people. Apart from identifying new vulnerability sites in the viral envelope proteins, these studies have shown that a fraction of these antibodies are produced by self/poly-reactive B-cells. These findings prompted us to revisit the B-cell differentiation and selection process during HIV/SIV infection and to consider B-cells as active players possibly shaping the helper T-cell program within germinal centers (GCs)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163463/selective-glucocorticoid-receptor-properties-of-gsk866-analogs-with-cysteine-reactive-warheads
#12
Chandra S Chirumamilla, Ajay Palagani, Balu Kamaraj, Ken Declerck, Marinus W C Verbeek, Ryabtsova Oksana, Karolien De Bosscher, Nadia Bougarne, Bart Ruttens, Kris Gevaert, René Houtman, Winnok H De Vos, Jurgen Joossens, Pieter Van Der Veken, Koen Augustyns, Xaveer Van Ostade, Annemie Bogaerts, Hans De Winter, Wim Vanden Berghe
Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand-binding strategies, classified as selective glucocorticoid receptor (GR) agonists (SEGRAs) or selective glucocorticoid receptor modulators (SEGRMs). In the current study, GSK866 analogs with electrophilic covalent-binding warheads were developed with potential SEGRA properties to improve their clinical safety profile for long-lasting topical skin disease applications...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163376/complete-genome-sequence-analysis-of-enterobacter-sp-sa187-a-plant-multi-stress-tolerance-promoting-endophytic-bacterium
#13
Cristina Andrés-Barrao, Feras F Lafi, Intikhab Alam, Axel de Zélicourt, Abdul A Eida, Ameerah Bokhari, Hanin Alzubaidy, Vladimir B Bajic, Heribert Hirt, Maged M Saad
Enterobacter sp. SA187 is an endophytic bacterium that has been isolated from root nodules of the indigenous desert plant Indigofera argentea. SA187 could survive in the rhizosphere as well as in association with different plant species, and was able to provide abiotic stress tolerance to Arabidopsis thaliana. The genome sequence of SA187 was obtained by using Pacific BioScience (PacBio) single-molecule sequencing technology, with average coverage of 275X. The genome of SA187 consists of one single 4,429,597 bp chromosome, with an average 56% GC content and 4,347 predicted protein coding DNA sequences (CDS), 153 ncRNA, 7 rRNA, and 84 tRNA...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163367/a-testis-specific-long-non-coding-rna-lncrna-tcam1-regulates-immune-related-genes-in-mouse-male-germ-cells
#14
Misuzu Kurihara, Kai Otsuka, Shin Matsubara, Akira Shiraishi, Honoo Satake, Atsushi P Kimura
Spermatogenesis is precisely controlled by hormones from the hypothalamus-pituitary-gonadal axis and testis-specific genes, but the regulatory mechanism is not fully understood. Recently, a large number of long non-coding RNAs (lncRNAs) are found to be transcribed at each stage of meiosis of male germ cells, and their functions in spermatogenesis have yet to be fully investigated. lncRNA-testicular cell adhesion molecule 1 (lncRNA-Tcam1) is a nuclear lncRNA which is specifically expressed in mouse male germ cells and presumed to play a role in gene regulation during meiosis...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29163083/effective-connectivity-analysis-of-the-brain-network-in-drivers-during-actual-driving-using-near-infrared-spectroscopy
#15
Zhian Liu, Ming Zhang, Gongcheng Xu, Congcong Huo, Qitao Tan, Zengyong Li, Quan Yuan
Driving a vehicle is a complex activity that requires high-level brain functions. This study aimed to assess the change in effective connectivity (EC) between the prefrontal cortex (PFC), motor-related areas (MA) and vision-related areas (VA) in the brain network among the resting, simple-driving and car-following states. Twelve young male right-handed adults were recruited to participate in an actual driving experiment. The brain delta [HbO2] signals were continuously recorded using functional near infrared spectroscopy (fNIRS) instruments...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29162924/dysbiosis-of-the-microbiome-in-gastric-carcinogenesis
#16
Natalia Castaño-Rodríguez, Khean-Lee Goh, Kwong Ming Fock, Hazel M Mitchell, Nadeem O Kaakoush
The gastric microbiome has been proposed as an etiological factor in gastric carcinogenesis. We compared the gastric microbiota in subjects presenting with gastric cancer (GC, n = 12) and controls (functional dyspepsia (FD), n = 20) from a high GC risk population in Singapore and Malaysia. cDNA from 16S rRNA transcripts were amplified (515F-806R) and sequenced using Illumina MiSeq 2 × 250 bp chemistry. Increased richness and phylogenetic diversity but not Shannon's diversity was found in GC as compared to controls...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162310/therapeutic-mechanisms-of-glucocorticoids
#17
REVIEW
Jolien Vandewalle, Astrid Luypaert, Karolien De Bosscher, Claude Libert
Glucocorticoids (GCs) have been used clinically for decades as potent anti-inflammatory and immunosuppressive agents. Nevertheless, their use is severely hampered by the risk of developing side effects and the occurrence of glucocorticoid resistance (GCR). Therefore, efforts to understand the complex mechanisms underlying GC function and GCR are ongoing. The goal is to generate new glucocorticoid receptor (GR) ligands that can dissociate anti-inflammatory from metabolic side effects and/or overcome GCR. In this review paper we discuss recent insights into GR-mediated actions in GCR and novel therapeutic strategies for acute and chronic inflammatory diseases...
November 18, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29162158/long-noncoding-rna-malat1-regulates-autophagy-associated-chemoresistance-via-mir-23b-3p-sequestration-in-gastric-cancer
#18
Hu YiRen, Yu YingCong, You Sunwu, Li Keqin, Tong Xiaochun, Chen Senrui, Chen Ende, Lin XiZhou, Chen Yanfan
BACKGROUND: Chemoresistance has long been recognized as a major obstacle in cancer therapy. Clarifying the underlying mechanism of chemoresistance would result in novel strategies to improve patient's response to chemotherapeutics. METHODS: lncRNA expression levels in gastric cancer (GC) cells was detected by quantitative real-time PCR (qPCR). MALAT1 shRNAs and overexpression vector were transfected into GC cells to down-regulate or up-regulate MALAT1 expression...
November 21, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/29161990/efficient-phenol-removal-from-petrochemical-wastewater-using-biochar-la-ultrasonic-persulphate-system-characteristics-reusability-and-kinetic-study
#19
Rasool Razmi, Bahman Ramavandi, Mehdi Ardjmand, Amir Heydarinasab
The entry of phenol into the environment causes damage to humans and living beings. Hence, it is essential to reduce phenol concentration from wastewaters to below standard level. This research has analysed the physio-chemical properties of a catalyst that has been developed-biochar-La, including BJH, BET, EDX, SEM, FTIR, pHpzc, and iodine number. The catalyst consisted of effective functional groups, including C=S, C-O, C=C, -COOH and O-H, with a specific surface area of 31.2 m(2)/g. The catalyst was used in the biochar-La/ultrasonic/persulphate system to remove phenol from wastewater...
November 22, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29161603/-37-cl-compound-specific-isotope-analysis-and-assessment-of-functional-genes-for-monitoring-monochlorobenzene-mcb-biodegradation-under-aerobic-conditions
#20
Massimo Marchesi, Luca Alberti, Orfan Shouakar-Stash, Ilaria Pietrini, Francesca de Ferra, Giovanna Carpani, Ramon Aravena, Andrea Franzetti, Tatiana Stella
A laboratory approach was adopted in this study to explore the potential of (37)Cl-CSIA in combination with (13)C-CSIA and Biological Molecular Tools (BMTs) to estimate the occurrence of monochloroenzene (MCB) aerobic biodegradation. A new analytical method for (37)Cl-CSIA of MCB was developed in this study. This methodology using a GC-IRMS allowed to determine δ(37)Cl values within an internal error of ±0.3‰. Samples from a heavily MCB contaminated site were collected and MCB aerobic biodegradation microcosms with indigenous cultures in natural and enhanced conditions were set up...
November 18, 2017: Science of the Total Environment
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