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https://www.readbyqxmd.com/read/28732399/analysis-of-emerging-organic-contaminants-in-water-fish-and-suspended-particulate-matter-spm-in-the-joint-danube-survey-using-solid-phase-extraction-followed-by-uhplc-ms-ms-and-gc-ms-analysis
#1
Robert Loos, Simona Tavazzi, Giulio Mariani, Gert Suurkuusk, Bruno Paracchini, Gunther Umlauf
In the third Joint Danube Survey (JDS3), emerging organic contaminants were analysed in the dissolved water phase of samples from the Danube River and its major tributaries. Analyses were performed using solid-phase extraction (SPE) followed by ultra-high-pressure liquid chromatography triple-quadrupole mass spectrometry (UHPLC-MS-MS) and gas chromatography-mass spectrometry (GC-MS). The polar organic compounds analysed by UHPLC-MS-MS were 1H-benzotriazole, methylbenzotriazoles, carbamazepine, 10,11-dihydro-10,11-dihydroxy-carbamazepine, diclofenac, sulfamethox-azole, 2,4-D (2,4-dichlorophenoxyacetic acid), MCPA (2-methyl-4-chlorophenoxyacetic acid), metolachlor, cybutryne (irgarol), terbutryn, DEET (N,N-diethyl-m-toluamide), and several perfluoroalkyl acids (C6-C9; C8=perfluorooctanoic acid (PFOA)) and perfluorooctansulfonic acid (PFOS)...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28732066/inhibition-of-pulmonary-%C3%AE-carotene-15-15-oxygenase-expression-by-glucocorticoid-involves-ppar%C3%AE
#2
Xiaoming Gong, Raju Marisiddaiah, Lewis P Rubin
β-carotene 15,15'-oxygenase (BCO1) catalyzes the first step in the conversion of dietary provitamin A carotenoids to vitamin A. This enzyme is expressed in a variety of developing and adult tissues, suggesting that its activity may regulate local retinoid synthesis. Vitamin A and related compounds (retinoids) are critical regulators of lung epithelial development, integrity, and injury repair. A balance between the actions of retinoids and glucocorticoids (GCs) promotes normal lung development and, in particular, alveolarization...
2017: PloS One
https://www.readbyqxmd.com/read/28731231/comparative-analysis-of-juice-volatiles-in-selected-mandarins-mandarin-relatives-and-other-citrus-genotypes
#3
Yuan Yu, Jinhe Bai, Chunxian Chen, Anne Plotto, Elizabeth A Baldwin, Frederick G Gmitter
BACKGROUND: Citrus fruit flavor is an important attribute prioritized in variety improvement. This study compared juice volatiles compositions from 13 selected citrus genotypes, including six mandarins (Citrus reticulata), three sour oranges (C. aurantium), one blood orange (C. sinensis), one lime (C. limonia), one clementine (C. clementina) and one satsuma (C. unshiu). RESULTS: Large differences were observed in volatiles compositions among the citrus genotypes...
July 21, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28731194/smurf1-promotes-the-proliferation-migration-and-invasion-of-gastric-cancer-cells
#4
Youmao Tao, Caixia Sun, Tao Zhang, Yan Song
Smad ubiquitin regulatory factor 1 (SMURF1), a well-known E3 ubiquitin ligase, targets substrate proteins for ubiquitination and proteasomal degradation. Accumulating studies have shown that SMURF1 acts as an oncogenic factor in human malignancies. However, the clinical significance of SMURF1 and its role in gastric cancer (GC) remain unclear. The expression of SMURF1 was detected in 68 cases of GC and corresponding tumor-adjacent specimens. Our results revealed that SMURF1 was prominently overexpressed in GC specimens compared to corresponding tumor-adjacent tissues...
July 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28731175/heat-shock-induced-hikeshi-protects-cell-viability-via-nuclear-translocation-of-heat-shock-protein-70
#5
Toru Yanoma, Kyoichi Ogata, Takehiko Yokobori, Munenori Ide, Erito Mochiki, Yoshitaka Toyomasu, Mitsuhiro Yanai, Norimichi Kogure, Akiharu Kimura, Masaki Suzuki, Nobuhiro Nakazawa, Tuya Bai, Tetsunari Oyama, Takayuki Asao, Ken Shirabe, Hiroyuki Kuwano
Heat shock proteins (HSPs), particularly HSP70, help restore normal cellular function following damage caused by stressors. HSP expression in tumor tissues indicates cancer progression, and while the development of HSP inhibitors is progressing, these substances are not widely used to treat cancer. HIKESHI (C11orf73) does not control the intracellular movement of HSP70 at normal temperatures; however, it does regulate the function and movements of HSP70 during heat shock. In this study, we examined the intracellular movement of HSP70 during heat shock to investigate the significance of HIKESHI expression in gastric cancer (GC) and determine if HIKESHI inhibition has cytotoxic effects...
July 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28731138/upregulation-of-long-non-coding-rna-dq786243-promotes-the-progression-of-gastric-cancer
#6
Ting Shan, Juanyun Fan, Qin Zhao, Kaiyuan Deng, Jiazeng Xia
Long non‑coding RNAs (lncRNAs) have been identified as key regulatory factors in various biological processes. Their dysregulation has been observed in several types of human cancer, including gastric cancer (GC). The aim of the present study was to investigate the putative roles of the lncRNA DQ786243 in the progression of GC, as well as evaluate its diagnostic and therapeutic potential in GC. The expression of DQ786243 in 82 pairs of GC tissues and adjacent healthy tissues, as well as in three GC cell lines and a human normal gastric epithelial cell line, was assessed using reverse transcription‑quantitative polymerase chain reaction...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28730944/integrating-bioassays-and-analytical-chemistry-as-an-improved-approach-to-support-safety-assessment-of-food-contact-materials
#7
Julien Veyrand, Maricel Marin-Kuan, Claudine Bezencon, Nancy Frank, Violaine Guérin, Sander Koster, Hélia Latado, Julie Mollergues, Amaury Patin, Dominique Piguet, Patrick Serrant, Jesus Varela, Benoît Schilter
Food contact materials (FCM) contain chemicals which can migrate into food and result in human exposure. Although it is mandatory to ensure that migration does not endanger human health, there is still no consensus on how to pragmatically assess the safety of FCM since traditional approaches would require extensive toxicological and analytical testing which are expensive and time consuming. Recently, the combination of bioassays, analytical chemistry and risk assessment has been promoted as a new paradigm to identify toxicologically relevant molecules and address safety issues...
July 21, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28730780/vascular-endothelial-growth-factor-gene-polymorphisms-and-gastric-cancer-risk-a-meta-analysis
#8
Meng Zhuang, Zhi Peng, Jian Wang, Xiangqian Su
PURPOSE: Vascular endothelial growth factor (VEGF) plays important roles in the process of tumor growth and metastasis. Although the association between VEGF polymorphisms and gastric cancer risk has been extensively studied, available results remain controversial. To derive a convincing estimation of the relationship, a meta-analysis containing 6 VEGF (+936C/T, -634G/C, -460T/C, +1612G/A, -2578C/A and -1154G/A) gene polymorphisms was performed. METHODS: We conducted a systematic search of PubMed and Chinese National Knowledge Infrastructure (CNKI) to select relevant articles...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28730527/characterization-of-the-complete-mitochondrial-genome-of-acanthoscelides-obtectus-coleoptera-chrysomelidae-bruchinae-with-phylogenetic-analysis
#9
Jie Yao, Hong Yang, Renhuai Dai
Acanthoscelides obtectus is a common species of the subfamily Bruchinae and a worldwide-distributed seed-feeding beetle. The complete mitochondrial genome of A. obtectus is 16,130 bp in length with an A + T content of 76.4%. It contains a positive AT skew and a negative GC skew. The mitogenome of A. obtectus contains 13 protein-coding genes (PCGs), 22 tRNA genes, two rRNA genes and a non-coding region (D-loop). All PCGs start with an ATN codon, and seven (ND3, ATP6, COIII, ND3, ND4L, ND6, and Cytb) of them terminate with TAA, while the remaining five (COI, COII, ND1, ND4, and ND5) terminate with a single T, ATP8 terminates with TGA...
July 20, 2017: Genetica
https://www.readbyqxmd.com/read/28729958/mutational-analysis-of-driver-genes-with-tumor-suppressive-and-oncogenic-roles-in-gastric-cancer
#10
Tianfang Wang, Yining Liu, Min Zhao
Gastric cancer (GC) is a complex disease with heterogeneous genetic mechanisms. Genomic mutational profiling of gastric cancer not only expands our knowledge about cancer progression at a fundamental genetic level, but also could provide guidance on new treatment decisions, currently based on tumor histology. The fact that precise medicine-based treatment is successful in a subset of tumors indicates the need for better identification of clinically related molecular tumor phenotypes, especially with regard to those driver mutations on tumor suppressor genes (TSGs) and oncogenes (ONGs)...
2017: PeerJ
https://www.readbyqxmd.com/read/28729344/exogenous-stress-hormones-alter-energetic-and-nutrient-costs-of-development-and-metamorphosis
#11
Lucas J Kirschman, Marshall D McCue, Justin G Boyles, Robin W Warne
Variation in environmental conditions during larval life stages can shape development during critical windows and have lasting effects on the adult organism. Changes in larval developmental rates in response to environmental conditions, for example, can trade-off with growth to determine body size and condition at metamorphosis, which can affect adult survival and fecundity. However, it is unclear how use of energy and nutrients shape trade-offs across life stage transitions because no studies have quantified these costs of larval development and metamorphosis...
July 20, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28729047/p53-deregulation-in-epstein-barr-virus-associated-gastric-cancer
#12
Joana Ribeiro, Mariana Malta, Ana Galaghar, Fernanda Silva, Luís Pedro Afonso, Rui Medeiros, Hugo Sousa
TP53 is a tumour suppressor gene frequently mutated in human cancers; nevertheless, in EBV-associated malignancies mutations are uncommon despite frequent deregulation of the p53 pathway. In this study, we aimed to investigate p53 expression, TP53 mRNA levels and TP53 mutations in EBV-associated gastric carcinoma (EBVaGC). A case-control study was performed using 46 patients: 15 EBVaGC and 31 EBV-negative GC (EBVnGC) cases. p53 expression was detected by immunohistochemistry (IHC), the evaluation of p53 mRNA levels was performed by RT-qPCR and TP53 mutations were investigated only in EBVaGC cases using the DNA sanger sequencing method...
July 17, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28728929/an-evaporation-assisted-dispersive-liquid-liquid-microextraction-technique-as-a-simple-tool-for-high-performance-liquid-chromatography-tandem-mass-spectrometry-determination-of-insecticides-in-wine
#13
Irina Timofeeva, Daria Kanashina, Leonid Moskvin, Andrey Bulatov
A sample pre-treatment technique based on evaporation-assisted dispersive liquid-liquid microextraction (EVA-DLLME), followed by HPLC-MS/MS has been developed for the determination of organophosphate insecticides (malathion, diazinon, phosalone) in wine samples. The procedure includes the addition of mixture of organic solvents (with density higher than water), consisting of the extraction (low density) and volatile (high density) solvents, to aqueous sample followed by heating of the mixture obtained, what promotes the volatile solvent evaporation and moving extraction solvent droplets from down to top of the aqueous sample and, as a consequence, microextraction of target analytes...
July 11, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28728263/-identification-of-mutations-associated-with-coronary-artery-lesion-susceptibility-in-kawasaki-disease-by-targeted-enrichment-of-genomic-region-sequencing-technique
#14
D Y Zhu, S R Song, L J Xie, F Qiu, J Yang, T T Xiao, M Huang
Objective: To screen and identify the mutations in Kawasaki disease by targeted enrichment of genomic region sequencing technique and investigate susceptibility genes associated with coronary artery lesion. Method: This was a case-control study.A total of 114 patients diagnosed as Kawasaki disease treated in Shanghai Children's Hospital between December 2015 and November 2016 were studied and another 45 healthy children who were physically examined in outpatient department were enrolled as control group. Patients were divided into two groups based on the results of echocardiogram...
July 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28728109/zero-valent-aluminum-for-reductive-removal-of-aqueous-pollutants-over-a-wide-ph-range-performance-and-mechanism-especially-at-near-neutral-ph
#15
Shiying Yang, Di Zheng, Tengfei Ren, Yixuan Zhang, Jia Xin
Zero-valent aluminum (ZVAl) draws much attention due to its strong reducibility. However, under neutral pH conditions, the reduction ability of ZVAl for pollutant removal has still been suspected because of the formed compact surface film of Al-(hydr)oxide. In this study, unmodified ZVAl was employed to reductively remove aqueous pollutants over a wide pH range, and its performance and mechanism, especially at near-neutral pH, were systematically studied for the first time. Results demonstrated that ZVAl had a wide range of pH applicability from 2 to 12, even in neutral environment...
July 6, 2017: Water Research
https://www.readbyqxmd.com/read/28727382/can-baseline-serum-creatinine-and-e-gfr-predict-renal-function-outcome-after-augmentation-cystoplasty-in-children
#16
Prempal Singh, Ankur Bansal, Virender Sekhon, Sandeep Nunia, M S Ansari
OBJECTIVE: To assess cut-off value of creatinine and glomerular filtration rate for augmentation cystoplasty (AC) in paediatric age-group. MATERIALS AND METHODS: Data of all paediatric-patients (<18 years) with small capacity bladder, in whom AC was advised between 2005-2015 were reviewed. All patients were divided in two-groups, AC-group and control-group (without AC). Creatinine and e-GFR were assessed at the time of surgery, at 6 months and at last follow-up...
July 20, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28727101/the-effect-of-frequency-of-supplementing-rumen-protected-unsaturated-fatty-acids-on-blood-serum-fatty-acid-profiles-in-beef-heifers-and-lactating-cows
#17
E K Cook, M E Garcia-Ascolani, R E Ricks, S K Duckett, G C Lamb, N DiLorenzo, N M Long
The objective of this study was to determine if supplementation frequency of rumen-protected fat (RPF) influences circulating serum concentrations of fatty acids (FA), NEFA, and urea nitrogen in beef heifers and lactating cows. In Exp. 1, 12 early gestation beef heifers were supplemented 0.5 kg of corn gluten feed (CGF) daily during a 2-wk adaptation period. During the last 3 d of adaptation, blood samples were collected immediately before supplementation and then 8 and 16 h postsupplementation daily. Each heifer was then randomly assigned to 1 of 3 supplementation frequency treatments of RPF (3, 5, or 7 d/wk) for 3 wk in a 3 × 3 Latin square design with 3 periods (4 heifers per treatment per period), with each treatment receiving the same amount of RPF and CGF per wk (1...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726786/calcium-binding-protein-s100a14-induces-differentiation-and-suppresses-metastasis-in-gastric-cancer
#18
Min Zhu, Hongyi Wang, Jiantao Cui, Wenmei Li, Guo An, Yuanming Pan, Qingying Zhang, Rui Xing, Youyong Lu
S100A14 is a calcium-binding protein involved in cell proliferation and differentiation as well as the metastasis of human tumors. In this study, we characterized the regulation of S100A14 expression between biological signatures and clinical pathological features in gastric cancer (GC). Our data demonstrated that S100A14 induced the differentiation of GC by upregulating the expression of E-cadherin and PGII. Moreover, S100A14 expression negatively correlated with cell migration and invasion in in vitro and in vivo experimental models...
July 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28726773/t-cell-autonomous-death-induced-by-regeneration-of-inert-glucocorticoid-metabolites
#19
Lourdes Rocamora-Reverte, Holger M Reichardt, Andreas Villunger, GJan Wiegers
Glucocorticoids (GC) are essential regulators of T-cell development and function. Activation of the immune system increases systemic adrenal-derived GC levels which downregulate immune activity as part of a negative feedback control system. Increasing evidence shows, however, that GC can also be derived from extra-adrenal sources such as the thymus or intestine, thus providing local control of GC-mediated effects. The thymus reportedly produces GC, but whether thymic epithelial cells or thymocytes produce GC acting either in an autocrine or paracrine fashion is not clear...
July 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28726757/characterization-of-essential-oil-composition-in-different-basil-species-and-pot-cultures-by-a-gc-ms-method
#20
Andrea Muráriková, Anton Ťažký, Jarmila Neugebauerová, Alexandra Planková, Josef Jampílek, Pavel Mučaji, Peter Mikuš
Basil (Ocimum L.) species are used as medicinal plants due to their essential oils exhibiting specific biological activity. The present work demonstrated that both the variety and season/conditions of cultivation had a significant effect on (i) the produced amount (extraction yield), (ii) qualitative, as well as (iii) quantitative profile of basil essential oil. Among studied basil varieties, a new variety, 'Mánes', was characterized for the first time. Based on our quantitative evaluation of GC-MS profiles, the following chemotypes and average concentrations of a main component were detected in the studied basil varieties: 'Ohře', 'Lettuce Leaf', 'Purple Opaal', 'Dark Green' (linalool, 5...
July 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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