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https://www.readbyqxmd.com/read/29793195/alcohol-and-drugs-use-among-drivers-injured-in-road-accidents-in-campania-italy-a-8-years-retrospective-analysis
#1
Anna Carfora, Carlo Pietro Campobasso, Paola Cassandro, Raffaella Petrella, Renata Borriello
A recent update of the Italian Road Traffic Law (RTL 41/2016), established severe penal sanctions when drivers, driving under the influence of alcohol (DUI) or drugs (DUID), are involved in road accident that results in death or injuries. A study was carried out to assess the trends of consumption of alcohol, illicit drugs or pharmaceutical among injured drivers suspected for DUI or DUID from 2009 to 2016 in the region of Campania (Italy). Confirmation toxicological analyses were performed on 780 blood samples and 1017 urine samples collected from 1797 injured drivers...
May 9, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29793117/metagenomic-insights-into-the-microbiota-profiles-and-bioaugmentation-mechanism-of-organics-removal-in-coal-gasification-wastewater-in-an-anaerobic-anoxic-oxic-system-by-methanol
#2
Weichao Xu, Yuxiu Zhang, Hongbin Cao, Yuxing Sheng, Haibo Li, Yuping Li, He Zhao, Xuefei Gui
Coal gasification wastewater is a typical high phenol-containing, toxic and refractory industrial wastewater. Here, lab-scale anaerobic-anoxic-oxic system was employed to treat real coal gasification wastewater, and methanol was added to oxic tank as the co-substrate to enhance the removal of refractory organic pollutants. The results showed that the average COD removal in oxic effluent increased from 24.9% to 36.0% by adding methanol, the total phenols concentration decreased from 54.4 to 44.9 mg/L. GC-MS analysis revealed that contents of phenolic components and polycyclic aromatic hydrocarbons (PAHs) were decreased compared to the control and their degradation intermediates were observed...
May 18, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29793099/carbon-monoxide-analysis-method-in-human-blood-by-airtight-gas-syringe-gas-chromatography-mass-spectrometry-ags-gc-ms-relevance-for-postmortem-poisoning-diagnosis
#3
S Oliverio, V Varlet
Carbon monoxide is one of the most abundant toxic air pollutants. Symptoms of a CO intoxication are non-specific, leading to a high number of misdiagnosed CO poisoning cases that are missing in the disease statistics. The chemical nature of the molecule makes it difficult to detect for long periods and at low levels, thus requiring a very accurate and sensitive method. Current methods capable of accurate and sensitive analyses are available, however an inconsistency between results and symptoms are frequently reported...
May 18, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29792983/impact-of-genetic-influence-on-serum-total-and-free-25-hydroxyvitamin-d-in-humans
#4
Balázs Szili, Boglárka Szabó, Péter Horváth, Bence Bakos, Györgyi Kirschner, János P Kósa, Erzsébet Toldy, Zsuzsanna Putz, Péter Lakatos, Ádám Tabák, István Takács
Serum 25-hydroxyvitamin D /25OHD/ levels in humans are determined primarily by environmental factors such as UV-B radiation and diet, including vitamin D intake. Although some genetic determinants of 25OHD levels have been shown, the magnitude of this association has not yet been clarified. The present study evaluates the genetic contribution to total- /t-25OHD/ and free-25OHD /f-25OHD/ in a representative sample of the Hungarian population (n = 462). The study was performed at the end of winter to minimize the effect of sunlight, which is a major determinant of serum vitamin D levels...
May 21, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29792963/extraction-characterization-and-biological-activity-of-sulfated-polysaccharides-from-seaweed-dictyopteris-divaricata
#5
Yinxin Cui, Xin Liu, Shufang Li, Limin Hao, Juan Du, DaHai Gao, Qiaozhen Kang, Jike Lu
Dictyopteris divaricata is a kind of important brown algae with many biological activities. It has been receiving more and more attention, yet there are rarely studies done on its polysaccharides. In this study, the optimum extraction and biological activity of seaweed polysaccharides from Dictyopteris divaricata (DDSP) were investigated. Response surface methodology (RSM), based on a three-level, three-variable Box-Behnken design (BBD), was employed to obtain the best possible combinations for maximum polysaccharides yield...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792200/wedge-shaped-microfluidic-chip-for-circulating-tumor-cells-isolation-and-its-clinical-significance-in-gastric-cancer
#6
Chaogang Yang, Nangang Zhang, Shuyi Wang, Dongdong Shi, Chunxiao Zhang, Kan Liu, Bin Xiong
BACKGROUND: Circulating tumor cells (CTCs) have great potential in both basic research and clinical application for the managements of cancer. However, the complicated fabrication processes and expensive materials of the existing CTCs isolation devices, to a large extent, limit their clinical translation and CTCs' clinical value. Therefore, it remains to be urgently needed to develop a new platform for achieving CTCs detection with low-cost, mass-producible but high performance. METHODS: In the present study, we introduced a novel wedge-shaped microfluidic chip (named CTC-ΔChip) fabricated by two pieces of glass through wet etching and thermal bonding technique for CTCs isolation, which achieved CTCs enrichment by different size without cell surface expression markers and CTCs identification with three-color immunocytochemistry method (CK+/CD45-/Nucleus+)...
May 23, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29791785/expressed-exome-capture-sequencing-eecseq-a-method-for-cost-effective-exome-sequencing-for-all-organisms
#7
Jonathan B Puritz, Katie E Lotterhos
Exome capture is an effective tool for surveying the genome for loci under selection. However, traditional methods require annotated genomic resources. Here, we present a method for creating cDNA probes from expressed mRNA, which are then used to enrich and capture genomic DNA for exon regions. This approach, called "EecSeq", eliminates the need for costly probe design and synthesis. We tested EecSeq in the eastern oyster, Crassostrea virginica, using a controlled exposure experiment. Four adult oysters were heat shocked at 36° C for 1 hour along with four control oysters kept at 14° C...
May 23, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29791595/microrna-3129-promotes-cell-proliferation-in-gastric-cancer-cell-line-sgc7901-via-positive-regulation-of-prb
#8
Shaofeng Yang, Nan Sheng, Lili Pan, Jing Cao, Jiao Liu, Ran Ma
Several microRNAs (miRNAs) have been reported as oncogenes or tumor suppressors in many cancers, including gastric cancer (GC). However, the role and molecular mechanism of miR-3129 in GC is largely unknown. We aimed to explore the function and the underlying molecular mechanism of miR-3129 in GC. Cancer tissues and corresponding adjacent tissues were collected from 50 patients with GC, and the expression of miR-3129 was detected by RT-qPCR. The expression of miR-3129 and pRb in human GC cell line SCG7091 was altered by transient transfection...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29791580/influence-of-aerobic-training-on-the-mechanics-of-ventricular-contraction-after-acute-myocardial-infarction-a-pilot-study
#9
Giovani Luiz De Santi, Henrique Turin Moreira, Eduardo Elias Vieira de Carvalho, Júlio César Crescêncio, André Schmidt, José Antônio Marin-Neto, Lourenço Gallo-Júnior
The study of myocardial contractility, based on the new anatomical concepts that govern cardiac mechanics, represents a promising strategy of analysis of myocardial adaptations related to physical training in the context of post-infarction. We investigated the influence of aerobic training on physical capacity and on the evaluation parameters of left ventricular contraction mechanics in patients with myocardial infarction. Thirty-one patients (55.1 ± 8.9 years) who had myocardial infarction in the anterior wall were prospectively investigated in three groups: interval training group (ITG) (n = 10), moderate training group (MTG) n = 10) and control group (CG) (n = 10)...
April 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29790763/decarbonylative-coupling-of-%C3%AE-keto-acids-and-ynamides-for-synthesis-of-%C3%AE-keto-imides
#10
Renjie Chen, Linwei Zeng, Bo Huang, Yangyong Shen, Sunliang Cui
A novel decarbonylative coupling of α-keto acids and ynamides with extrusion of CO for synthesis of β-keto imides is reported. This process features mild reaction conditions, a broad substrate scope, and high efficiency. An isotope-labeling reaction and GC analysis were conducted to elucidate a plausible reaction mechanism.
May 23, 2018: Organic Letters
https://www.readbyqxmd.com/read/29790747/characterization-of-the-potent-aroma-compounds-in-preserved-egg-yolk-by-gas-chromatography-olfactometry-quantitative-measurements-and-odor-activity-value
#11
Yu Zhang, Yuping Liu, Wenxi Yang, Jia Huang, Yingqiao Liu, Mingquan Huang, Baoguo Sun, Changlin Li
To characterize potent odor-active compounds in preserved egg yolk (PEY), volatile compounds were isolated by headspace solid-phase microextraction and solvent-assisted flavor evaporation. Gas chromatography-olfactometry (GC-O) and gas chromatography-mass spectrometry (GC-MS) analyses identified a total of 53 odor-active compounds by comparing the odor characteristics, MS data, and retention indices with those of reference compounds. Twenty-seven odorants were detected in at least 5 isolates that were extracted and analyzed by the same method, and their flavor dilution (FD) factors, ranging from 1 to 2048, were measured by aroma extract dilution analysis (AEDA)...
May 23, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29790675/loss-of-cyclin-dependent-kinase-like-2-predicts-poor-prognosis-in-gastric-cancer-and-its-overexpression-suppresses-cells-growth-and-invasion
#12
Chia-Lang Fang, Yih-Huei Uen, Han-Kun Chen, You-Cheng Hseu, Chih-Chan Lin, Shih-Ting Hung, Ding-Ping Sun, Kai-Yuan Lin
Cyclin-dependent kinase-like 2 (CDKL2), a new member of the cyclin-dependent kinase family, may be involved in gastric cancer (GC) progression. Thus, we conducted this study to explore the clinical effect of CDKL2 in GC. Immunohistochemistry was used to measure CDKL2 levels in gastric tissues. The association of a high CDKL2 level with clinical and pathological characteristics, and the correlation between the CDKL2 level and disease-free and overall survival were analyzed. Transfection was employed to overexpress CDKL2 in GC cells and to investigate the effect of CDKL2 overexpression on cell proliferation and invasion...
May 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29790507/a-novel-liquid-chromatography-detector-based-on-a-dielectric-barrier-discharge-molecular-emission-spectrometer-with-online-microwave-assisted-hydrolysis-for-determination-of-dithiocarbamates
#13
Bingjun Han, Ya Li, Bing Qian, Yan He, Lixu Peng, Huamei Yu
A novel detector for liquid chromatography (LC) for the determination of dithiocarbamate (DTC) fungicides is presented with a miniaturized dielectric barrier discharge-microplasma molecular emission spectrometer and an online microwave-assisted hydrolysis reactor. DTCs in the sample/standard solutions together with SnCl2 were pumped to the reactor to be converted to CS2 with high efficiency, which was then separated from the liquid phase and transformed for the detection of the specific molecular emission at 257...
May 23, 2018: Analyst
https://www.readbyqxmd.com/read/29790345/characterization-of-the-major-odor-active-compounds-in-dry-jujubes-cultivars-by-application-of-gas-chromatography-olfactometry-and-odor-activity-value
#14
Zuobing Xiao, Jiancai Zhu
The volatile compounds of jujube (Ziziphus jujube Mill.) puree obtained from three cultivars: 'jinsixiaozao' (Y1), 'youzao' (Y2), and 'yuzao' (Y3) were analyzed by gas chromatography-olfactometry (GC-O), gas chromatography-mass spectrometry, GC-flame photometric detection, and nitrogen phosphorus detector. The results showed that a total of 37, 37, and 35 odor-active compounds were identified by GC-O in samples of Y1, Y2, and Y3, respectively. In addition, the odor activity value (OAV) was used to determine the important compounds...
May 23, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29790285/peripapillary-vessel-density-changes-in-leber-s-hereditary-optic-neuropathy-a-new-biomarker
#15
Nicole Balducci, Maria Lucia Cascavilla, Antonio Ciardella, Chiara La Morgia, Giacinto Triolo, Vincenzo Parisi, Francesco Bandello, Alfredo A Sadun, Valerio Carelli, Piero Barboni
IMPORTANCE: The contribution of the microvascular supply to the pathogenesis of Leber's Hereditary Optic Neuropathy (LHON) is poorly understood. BACKGROUND: We aimed at measuring the peripapillary capillary vessel density (VD) using optical coherence tomography angiography (OCT-A) at different stages of LHON. DESIGN: Prospective, cross-sectional, multicenter, observational study. PARTICIPANTS: Twenty-two LHON patients divided in 4 groups: unaffected mutation carriers (LHON-u); early subacute stage (LHON-e); late subacute stage (LHON-l); chronic stage (LHON-ch)...
May 22, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29790169/met-in-gastric-cancer-with-liver-metastasis-the-relationship-between-met-amplification-and-met-overexpression-in-primary-stomach-tumors-and-liver-metastasis
#16
Han S Kim, Hong J Chon, Hyunki Kim, Su-Jin Shin, Volker Wacheck, Aaron M Gruver, Jong S Kim, Sun Y Rha, Hyun C Chung
BACKGROUND AND OBJECTIVES: Although MET amplification/overexpression was observed in a subset of gastric cancer (GC) patients, the relationship between MET amplification/overexpression in primary GC and liver metastasis was unclear. METHODS: GC samples and matched liver metastases (N = 47) were analyzed by fluorescence/silver in-situ hybridization (FISH/SISH) and by immunohistochemistry for MET amplification and MET expression, respectively. MET-copy number (CN) and Met expression data from The Cancer Genome Atlas Stomach Adenocarcinoma (TCGA-STAD, N = 356) were also analyzed...
May 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29789713/upregulation-of-the-long-noncoding-rna-foxd2-as1-promotes-carcinogenesis-by-epigenetically-silencing-ephb3-through-ezh2-and-lsd1-and-predicts-poor-prognosis-in-gastric-cancer
#17
Tong-Peng Xu, Wen-Yu Wang, Pei Ma, You Shuai, Kun Zhao, Yan-Fen Wang, Wei Li, Rui Xia, Wen-Ming Chen, Er-Bao Zhang, Yong-Qian Shu
Accumulating data indicate that long noncoding RNAs (lncRNAs) serve as important modulators in biological processes and are dysregulated in diverse tumors. The function of FOXD2-AS1 in gastric cancer (GC) progression and related biological mechanisms remain undefined. A comprehensive analysis identified that FOXD2-AS1 enrichment was upregulated markedly in GC and positively correlated with a large tumor size, a later pathologic stage, and a poor prognosis. Gene-set enrichment analysis (GSEA) in GEO datasets uncovered that cell cycle and DNA replication associated genes were enriched in patients with high FOXD2-AS1 expression...
May 23, 2018: Oncogene
https://www.readbyqxmd.com/read/29789659/comparison-of-glaucoma-diagnostic-ability-between-wide-field-swept-source-oct-retinal-nerve-fiber-layer-maps-and-spectral-domain-oct
#18
Won June Lee, Sohee Oh, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To compare the diagnostic ability of wide-field swept-source optical coherence tomography (SS-OCT) retinal nerve fiber layer (RNFL) maps with spectral-domain OCT (SD-OCT) maps for detection of preperimetric (PPG) and early glaucoma (EG). PATIENTS AND METHODS: One hundred and forty-six eyes, including 37 healthy eyes, 38 eyes with PPG, and 71 eyes with EG, were analyzed. The patients underwent both SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA, USA) and wide-field SS-OCT scanning (DRI-OCT-1 Atlantis; Topcon, Tokyo, Japan)...
May 23, 2018: Eye
https://www.readbyqxmd.com/read/29789551/epidermal-glucocorticoid-and-mineralocorticoid-receptors-act-cooperatively-to-regulate-epidermal-development-and-counteract-skin-inflammation
#19
Judit Bigas, Lisa M Sevilla, Elena Carceller, Julia Boix, Paloma Pérez
Endogenous and synthetic glucocorticoids (GCs) regulate epidermal development and combat skin inflammatory diseases. GC actions can be mediated through the GC receptor (GR) and/or the mineralocorticoid receptor (MR), highly homologous ligand-activated transcription factors. While the role of GR as a potent anti-inflammatory mediator is well known, that of MR is not as clear, nor is whether these receptors cooperate or antagonize each other in the epidermis. To address this, we generated mice with epidermal-specific loss of both receptors (double knockout, DKO), and analyzed the phenotypical and functional consequences relative to single KOs or controls (CO)...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29789536/long-noncoding-rna-gastric-cancer-related-lncrna1-mediates-gastric-malignancy-through-mirna-885-3p-and-cyclin-dependent-kinase-4
#20
Zhijuan Lin, Zhixia Zhou, Hang Guo, Yuqi He, Xin Pang, Xumei Zhang, Ying Liu, Xiang Ao, Peifeng Li, Jianxun Wang
Gastric cancer (GC) is one of the most common malignancy and the third leading cancer-related death in China. Long noncoding RNAs (lncRNAs) have been implicated in numerous tumors, including GC, however, the mechanism of many functional lncRNAs is still unclear. In this study, we identified the abundantly expressed lncRNA, RP11-290F20.3, in GC cells and patient tumor tissues. We named this lncRNA as GC-related lncRNA1 (GCRL1), which could regulate gastric cell proliferation and metastasis, both in vitro and in vivo...
May 22, 2018: Cell Death & Disease
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