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Juvenile Bipolar Disorder

Anna Jopowicz, Agnieszka Piechal, Iwona Kurkowska-Jastrzębska
AIM: Valproic acid (VPA) is used in epilepsy treatment and as a stabilizer in bipolar affective disorder for over 40 years. Although, the pharmacokinetic properties of valproic acid are well known, it is often forgotten that the formulation of the drug significantly influences its gastrointestinal absorption. CASE: We are describing the case of 30 year-old female patient, diagnosed at the age of 13 with juvenile myoclonic epilepsy. Complete ineffectiveness of the treatment was caused by malabsorption of sodium valproate and valproic acid in the patient...
March 12, 2017: Neurologia i Neurochirurgia Polska
M Woodbury-Smith, D A Bilder, J Morgan, L Jerominski, T Darlington, T Dyer, A D Paterson, H Coon
BACKGROUND: It has long been recognized that there is an association between enlarged head circumference (HC) and autism spectrum disorder (ASD), but the genetics of HC in ASD is not well understood. In order to investigate the genetic underpinning of HC in ASD, we undertook a genome-wide linkage study of HC followed by linkage signal targeted association among a sample of 67 extended pedigrees with ASD. METHODS: HC measurements on members of 67 multiplex ASD extended pedigrees were used as a quantitative trait in a genome-wide linkage analysis...
2017: Journal of Neurodevelopmental Disorders
N Dugand, S Thümmler, C Pradier, F Askenazy
BACKGROUND: Child and adolescent psychiatrists are frequently confronted with suicide attempts and comorbid mood disorders. Diagnoses of juvenile bipolar disorders (BD) are rare and controversial and standardized assessment is helpful for a reliable diagnosis. The main objective of this study was to identify the number of juvenile bipolar disorder diagnoses according to DSM-5 criteria in a population of children and adolescents hospitalized for suicide attempts. Secondary objectives were the assessment of a patient's characteristics and the comparison of suicide attempt recurrence during 12 months of follow-up...
March 2, 2017: L'Encéphale
K-Alexander Engelhardt, Eberhard Fuchs, Rainer K W Schwarting, Markus Wöhr
Communication is the act of information transfer between sender and receiver. In rats, vocal communication can be studied through ultrasonic vocalizations (USV). 50-kHz USV occur in appetitive situations, most notably juvenile play, likely expressing the sender׳s positive affective state. Such appetitive 50-kHz USV serve important pro-social communicative functions and elicit social exploratory and approach behavior in the receiver. Emission of 50-kHz USV can be induced pharmacologically by the administration of psychostimulant drugs, such as amphetamine...
January 21, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Alessandra Tesei, Alessandro Crippa, Silvia Busti Ceccarelli, Maddalena Mauri, Massimo Molteni, Carlo Agostoni, Maria Nobile
Over the last 15 years, considerable interest has been given to the potential role of omega-3 polyunsaturated fatty acids (PUFAs) for understanding pathogenesis and treatment of neurodevelopmental and psychiatric disorders. This review aims to systematically investigate the scientific evidence supporting the hypothesis on the omega-3 PUFAs deficit as a risk factor shared by different pediatric neuropsychiatric disorders. Medline PubMed database was searched for studies examining blood docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) status in children with neuropsychiatric disorders...
December 17, 2016: European Child & Adolescent Psychiatry
Amber L Beckley, Avshalom Caspi, Honalee Harrington, Renate M Houts, Tara Renae Mcgee, Nick Morgan, Felix Schroeder, Sandhya Ramrakha, Richie Poulton, Terrie E Moffitt
PURPOSE: To describe official adult-onset offenders, investigate their antisocial histories and test hypotheses about their origins. METHODS: We defined adult-onset offenders among 931 Dunedin Study members followed to age 38, using criminal-court conviction records. RESULTS: Official adult-onset offenders were 14% of men, and 32% of convicted men, but accounted for only 15% of convictions. As anticipated by developmental theories emphasizing early-life influences on crime, adult-onset offenders' histories of antisocial behavior spanned back to childhood...
September 1, 2016: Journal of Criminal Justice
Jean Xavier, Nadège Bourvis, Antoine Tanet, Tatiana Ramos, Didier Perisse, Isabelle Marey, David Cohen, Angèle Consoli
OBJECTIVE: Wolfram syndrome (WS, MIM 222300) is a rare autosomal, recessive neurodegenerative disorder associated with mutations in WFS1, a gene that has been associated with bipolar disorder (BD). WS, characterized by the association of juvenile-onset diabetes mellitus (DM) and bilateral progressive optic atrophy (BPOA), encompasses several other clinical features, including cognitive impairments and psychiatric disorders. Detailed data on the psychiatric phenotype are still scarce, and how WS relates to BD is still unknown...
April 5, 2016: Journal of Child and Adolescent Psychopharmacology
P S Apaolaza, A Del Pozo-Rodríguez, M A Solinís, J M Rodríguez, U Friedrich, J Torrecilla, B H F Weber, A Rodríguez-Gascón
X-linked juvenile retinoschisis (XLRS) is a retinal degenerative disorder caused by mutations in the RS1 gene encoding a protein termed retinoschisin. The disease is an excellent candidate for gene replacement therapy as the majority of mutations have been shown to lead to a complete deficiency of the secreted protein in the retinal structures. In this work, we have studied the ability of non-viral vectors based on solid lipid nanoparticles (SLN) to induce the expression of retinoschisin in photoreceptors (PR) after intravitreal administration to Rs1h-deficient mice...
June 2016: Biomaterials
Giulia Serra
No abstract text is available yet for this article.
April 2016: Lancet Psychiatry
Liang-Jen Wang, Yu-Chiau Shyu, Shin-Sheng Yuan, Chun-Ju Yang, Kang-Chung Yang, Tung-Liang Lee, Sheng-Yu Lee
UNLABELLED: In this study, we aimed to evaluate the relationship between attention-deficit/hyperactivity disorder (ADHD) during childhood and subsequent diagnoses of bipolar disorder (BD), as well as to determine whether the pharmacotherapy for ADHD (methylphenidate and atomoxetine) influence the risks of developing BD. A nationwide cohort of patients newly diagnosed with ADHD (n = 144,920) and age- and gender-matching controls (n = 144,920) were found in Taiwan's National Health Insurance database from January 2000 to December 2011...
January 2016: Journal of Psychiatric Research
John Kasinathan
OBJECTIVE: Describe characteristics of mentally ill young offenders released from custody and predictors of those who rapidly returned to custody. METHOD: Ambidirectional cohort study of 51 young males with mental disorders released from the largest New South Wales Juvenile Justice Centre (2005-2007), a health file audit at time of release and prospective determination of reincarceration. RESULTS: Overall 47% were Aboriginal, 43% originated from regional communities, substance disorders were highly prevalent and only 12% accessed prior community mental health care...
October 2015: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Rene L Olvera, David C Glahn, Louise O'Donnell, Carrie E Bearden, Jair C Soares, Anderson M Winkler, Steven R Pliszka
BACKGROUND: There is increasing evidence that bipolar disorder (BD) and conduct disorder (CD) are co-occurring disorders. Magnetic resonance imaging has revealed differences in the structure and function of the frontal cortex in these disorders when studied separately; however, the impact of BD comorbidity on brain structure in adolescents with CD has not yet been examined. METHOD: We conducted an optimized voxel based morphometry (VBM) study of juvenile offenders with the following diagnoses: conduct disorder with comorbid bipolar disorder (CD-BD; n = 24), conduct disorder without bipolar disorder (CD; n = 24) and healthy controls (HC, n = 24)...
2014: Journal of Clinical Medicine
Gianni L Faedda, Ciro Marangoni, Giulia Serra, Paola Salvatore, Gabriele Sani, Gustavo H Vázquez, Leonardo Tondo, Paolo Girardi, Ross J Baldessarini, Athanasios Koukopoulos
OBJECTIVE: To evaluate the presence of affective signs and symptoms as precursors of bipolar disorder in prospective studies, including assessment of their prevalence, duration, and predictive value. DATA SOURCES: We followed PRISMA guidelines to search PubMed, CINAHL, PsycINFO, EMBASE, SCOPUS, and ISI Web of Science databases to May 31, 2013, using the terms bipolar disorder AND (antecedent* OR predict* OR prodrom* OR prospect*) AND (diagnosis OR development). Hand searching of identified reports led to additional relevant references...
May 2015: Journal of Clinical Psychiatry
Philippe Gélisse, Arielle Crespel
Myoclonic status epilepticus or mixed absence-myoclonic status is uncommon in juvenile myoclonic epilepsy (JME), often precipitated by sleep deprivation, withdrawal of medication, or inadequate antiepileptic drugs (Thomas et al., 2006; Crespel et al., 2013). Such episodes respond well to benzodiazepines or valproate (Crespel et al., 2013). We present the video-EEG of a 24-year-old woman with JME and bipolar disorder. She had a confusional state five days after withdrawal of clonazepam (14 mg/d) and introduction of oxazepam (200 mg/d), followed by catatonic stupor with subtle myoclonus of the face and the arms...
March 2015: Epileptic Disorders: International Epilepsy Journal with Videotape
Pierre Alexis Geoffroy, Renaud Jardri, Bruno Etain, Pierre Thomas, Benjamin Rolland
Bipolar disorder (BD) is a severe mental condition with neurodevelopmental features that clinically results in pathological fluctuations of mood. Whereas it was classically or traditionally considered as an adult-onset disorder, recent findings suggest that BD may occur very early in the life course, thus, determining what is now called Juvenile bipolar disorder (JBD). One of the reasons for which JBD has been so difficult to identify is that JBD primary symptoms vary much from the typical adulthood BD clinical expression...
September 2014: La Presse Médicale
Julie Brunelle, Vanessa Milhet, Angèle Consoli, David Cohen
Juvenile mania is a concept widely developed but also highly debated since the 1990s. In the heart of this debate, Severe Mood Dysregulation (SMD) and "Temper Dysregulation disorder with Dysphoria" (recently integrated in DSM-5) showed their interest. Actually, the objective is to distinguish two clinical phenotypes in order to avoid confusion between (1) what would raise more of mood dysregulation with chronic manic like symptoms, and (2) bipolar disorder type I with episodic and acute manic episodes. Therapeutic stakes are major...
April 2014: La Revue du Praticien
Joana C Narvaez, Cristian P Zeni, Roberta P Coelho, Flavia Wagner, Gabriel F Pheula, Carla R Ketzer, Clarissa M Trentini, Silzá Tramontina, Luis A Rohde
OBJECTIVE: To assess differences in executive functioning between children and adolescents with attention-deficit/hyperactivity disorder (ADHD) comorbid or not with bipolar disorder (BD), and to study the neuropsychological profile of subjects with the comorbidity in a clinical sample from a developing country. METHOD: Case-control study comparing 23 participants with BD + ADHD and 85 ADHD-only subjects aged 6 to 17 years old. Both groups were drug-free. Executive function domains were assessed with the Stroop Test, the Wisconsin Card Sorting Test, and the Continuous Performance Test II...
January 2014: Revista Brasileira de Psiquiatria
Stewart Adelson, Robinette Bell, Adam Graff, David Goldenberg, Elizabeth Haase, Jennifer I Downey, Richard C Friedman
While there is consensus that bipolar disorder exists in children and adolescents, its diagnostic criteria are debated. Excessive sexual behavior has been reported in youth who may have juvenile bipolar disorder (JBD), and has been termed "hypersexuality." Although there is no universal definition of this term, this observation has led to a hypothesis that increased sexual behavior characterizes the bipolar syndrome in children and adolescents, and differentiates it from attention deficit hyperactivity disorder...
2013: Psychodynamic Psychiatry
M Cederlöf, P Ostberg, E Pettersson, H Anckarsäter, C Gumpert, S Lundström, P Lichtenstein
BACKGROUND: Psychotic-like experiences (PLEs) and juvenile mania in adolescence index risk for severe psychopathology in adulthood. The importance of childhood problems with communication, reading, speech and mathematics for the development of PLEs and juvenile mania is not well understood. METHOD: Through the Child and Adolescent Twin Study in Sweden, we identified 5812 children. The parents were interviewed about their children's development at age 9 or 12 years...
April 2014: Psychological Medicine
Cristian Patrick Zeni, Silzá Tramontina, Thamis Aline Zeni, Roberta Coelho, Gabriel Pheula, Julio Bernardi, Ursula Maldaner, Talita Lopes Silva, Angélica Salatino-Oliveira, Mara Hutz, Luis Augusto Rohde
OBJECTIVES: To assess the role of the Val66Met polymorphism at the brain-derived neurotrophic factor (BDNF) gene on the performance of children and adolescents with bipolar disorder [juvenile bipolar disorder (JBD)] on the Wisconsin Card Sorting Test (WCST). METHODS: Children and adolescents were assessed by the K-SADS-PL and a clinical evaluation for BD and comorbid conditions. Manic and depressive symptoms were assessed with the Young Mania Rating Scale and the Children Depression Rating Scale - Reviewed...
March 2013: Revista Brasileira de Psiquiatria
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