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JOURNAL ARTICLE
S Y Zhang, S Q Gao, Z Y Wang, M Wu, Z Tian, S Y Zhang
Objective: To investigate the risk factors and long-term prognosis of major adverse cardiovascular events(MACEs) in patients with dilated cardiomyopathy (DCM). Methods: This study was a single-center retrospective cohort study. Clinical information from 300 patients with DCM hospitalized in Peking Union Medical College Hospital from April 2013 to April 2023 was collected. Based on echocardiography results, the patients were divided into two groups: isolated DCM and DCM with left ventricular non-compaction cardiomyopathy (LVNC)...
April 24, 2024: Zhonghua Xin Xue Guan Bing za Zhi
#2
JOURNAL ARTICLE
Trie Arni Djunadi, Youjin Oh, Jeeyeon Lee, Jisang Yu, Liam Il-Young Chung, Yeunho Lee, Leeseul Kim, Timothy Hong, Soowon Lee, Zunairah Shah, Joo Hee Park, Sung Mi Yoon, Young Kwang Chae
INTRODUCTION: Immune checkpoint inhibitors (ICIs) may be associated with hyperprogressive disease (HPD). However, there is currently no standardized definition of HPD, with its risk factors and clinical implications remaining unclear. We investigated HPD in lung cancer patients undergoing immunotherapy, aiming to redefine HPD, identify risk factors, and assess its impact on survival. METHODS: Clinical and radiologic data from 121 non-small cell lung cancer (NSCLC) patients with 136 immunotherapy cases were reviewed retrospectively...
March 16, 2024: Clinical Lung Cancer
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JOURNAL ARTICLE
Giovanni Davogustto, Quinn S Wells, Frank E Harrell, Stephen J Greene, Dan M Roden, Lynne W Stevenson
BACKGROUND: An angiotensin receptor-neprilysin inhibitor (ARNI) is the preferred renin-angiotensin system (RAS) inhibitor for heart failure with reduced ejection fraction (HFrEF). Among eligible patients, insurance status and prescriber concern regarding out-of-pocket costs may constrain early initiation of ARNI and other new therapies. OBJECTIVES: In this study, the authors sought to evaluate the association of insurance and other social determinants of health with ARNI initiation at discharge from HFrEF hospitalization...
April 4, 2024: JACC. Heart Failure
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JOURNAL ARTICLE
Stephen J Greene, Hanna K Gaggin, Mo Zhou, Lori D Bash, Dominik Lautsch, Laurence Djatche, Yan Song, James Signorovitch, Andra S Stevenson, Robert O Blaustein, Javed Butler
AIMS: Patients with HFrEF and worsening HF events (WHFE) are at particularly high risk and urgently need disease-modifying therapy. CHART-HF assessed treatment patterns and reasons for medication decisions among HFrEF patients with and without WHFE. METHODS AND RESULTS: CHART-HF collected retrospective electronic medical records of outpatients with HF and EF < 45% between 2017-2019 from a nationwide panel of 238 cardiologists (458 patients) and the Geisinger Health System (GHS) medical record (1000 patients)...
April 19, 2024: ESC Heart Failure
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JOURNAL ARTICLE
Hongtao Yin, Lixiang Ma, Yanqing Zhou, Xiuying Tang, Runjun Li, Yingjun Zhou, Jiaxiu Shi, Jun Zhang
Effects of angiotensin receptor/neprilysin inhibitors (ARNI) on ventricular remodeling in patients with heart failure, especially heart failure with reduced ejection fraction (HFrEF), are better than those of angiotensin-converting enzyme inhibitors (ACEI). Acute myocardial infarction (AMI) complicated by mitral regurgitation exacerbates ventricular remodeling and increases the risk of heart failure. There is limited evidence on the effects of early administration of ARNI in patients with AMI complicated by mitral regurgitation...
April 18, 2024: Heart and Vessels
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JOURNAL ARTICLE
Jonas Ghouse, Gardar Sveinbjörnsson, Marijana Vujkovic, Anne-Sofie Seidelin, Helene Gellert-Kristensen, Gustav Ahlberg, Vinicius Tragante, Søren A Rand, Joseph Brancale, Silvia Vilarinho, Pia Rengtved Lundegaard, Erik Sørensen, Christian Erikstrup, Mie Topholm Bruun, Bitten Aagaard Jensen, Søren Brunak, Karina Banasik, Henrik Ullum, Niek Verweij, Luca Lotta, Aris Baras, Tooraj Mirshahi, David J Carey, David E Kaplan, Julie Lynch, Timothy Morgan, Tae-Hwi Schwantes-An, Daniel R Dochtermann, Saiju Pyarajan, Philip S Tsao, Triin Laisk, Reedik Mägi, Julia Kozlitina, Anne Tybjærg-Hansen, David Jones, Kirk U Knowlton, Lincoln Nadauld, Egil Ferkingstad, Einar S Björnsson, Magnus O Ulfarsson, Árni Sturluson, Patrick Sulem, Ole B Pedersen, Sisse R Ostrowski, Daniel F Gudbjartsson, Kari Stefansson, Morten Salling Olesen, Kyong-Mi Chang, Hilma Holm, Henning Bundgaard, Stefan Stender
We report a multi-ancestry genome-wide association study on liver cirrhosis and its associated endophenotypes, alanine aminotransferase (ALT) and γ-glutamyl transferase. Using data from 12 cohorts, including 18,265 cases with cirrhosis, 1,782,047 controls, up to 1 million individuals with liver function tests and a validation cohort of 21,689 cases and 617,729 controls, we identify and validate 14 risk associations for cirrhosis. Many variants are located near genes involved in hepatic lipid metabolism...
April 17, 2024: Nature Genetics
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JOURNAL ARTICLE
LaShawn Glasgow, Christian Douglas, Joel G Sprunger, Aimee N C Campbell, Redonna Chandler, Anindita Dasgupta, JaNae Holloway, Katherine R Marks, Sara M Roberts, Linda Sprague Martinez, Katherine Thompson, Roger D Weiss, Arnie Aldridge, Kat Asman, Carolina Barbosa, Derek Blevins, Deborah Chassler, Lindsay Cogan, Laura Fanucchi, Megan E Hall, Timothy Hunt, Elizabeth Jadovich, Frances R Levin, Patricia Lincourt, Michelle R Lofwall, Vanessa Loukas, Ann Scheck McAlearney, Edward Nunes, Emmanuel Oga, Devin Oller, Maria Rudorf, Ann Marie Sullivan, Jeffery Talbert, Angela Taylor, Julie Teater, Nathan Vandergrift, Kristin Woodlock, Gary A Zarkin, Bridget Freisthler, Jeffrey H Samet, Sharon L Walsh, Nabila El-Bassel
BACKGROUND: The U.S. opioid overdose crisis persists. Outpatient behavioral health services (BHS) are essential components of a comprehensive response to opioid use disorder and overdose fatalities. The Helping to End Addiction Long-Term® (HEALing) Communities Study developed the Communities That HEAL (CTH) intervention to reduce opioid overdose deaths in 67 communities in Kentucky, Ohio, New York, and Massachusetts through the implementation of evidence-based practices (EBPs), including BHS...
April 5, 2024: Drug and Alcohol Dependence
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REVIEW
Jose Antonio, Cassandra Evans, Arny A Ferrando, Jeffrey R Stout, Brandi Antonio, Harry Cinteo, Patrick Harty, Shawn M Arent, Darren G Candow, Scott C Forbes, Chad M Kerksick, Flavia Pereira, Drew Gonzalez, Richard B Kreider
Protein supplementation often refers to increasing the intake of this particular macronutrient through dietary supplements in the form of powders, ready-to-drink shakes, and bars. The primary purpose of protein supplementation is to augment dietary protein intake, aiding individuals in meeting their protein requirements, especially when it may be challenging to do so through regular food (i.e. chicken, beef, fish, pork, etc.) sources alone. A large body of evidence shows that protein has an important role in exercising and sedentary individuals...
December 2024: Journal of the International Society of Sports Nutrition
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JOURNAL ARTICLE
Aiga Ivdre, Mikelis Kirpluks, Arnis Abolins, Laima Vevere, Beatrise Sture, Aigars Paze, Daniela Godina, Janis Rizikovs, Ugis Cabulis
The utilization of polyols derived from renewable sources presents an opportunity to enhance the sustainability of rigid polyurethane (PUR) foams, thereby contributing to the advancement of a circular bioeconomy. This study explores the development of PUR rigid foams exclusively using polyols sourced from second-generation renewable biomass feedstocks, specifically depolymerized birch bark suberin (suberinic acids) and tall oil fatty acids. The polyols achieved a total renewable material content as high as 74%, with a suberinic acid content of 37%...
March 29, 2024: Polymers
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JOURNAL ARTICLE
Christian C Garcia, Dylan K Richards, Felicia R Tuchman, Kevin A Hallgren, Henry R Kranzler, Henri-Jean Aubin, Stephanie S O'Malley, Karl Mann, Arnie Aldridge, Michaela Hoffman, Raymond F Anton, Katie Witkiewitz
AIMS: Among individuals with alcohol use disorder (AUD), sleep disturbances are pervasive and contribute to the etiology and maintenance of AUD. However, despite increased attention toward the relationship between alcohol use and sleep, limited empirical research has systematically examined whether reductions in drinking during treatment for AUD are associated with improvements in sleep problems. METHODS: We used data from a multisite, randomized, controlled trial that compared 6 months of treatment with gabapentin enacarbil extended-release with placebo for adults with moderate-to-severe AUD (N = 346)...
March 16, 2024: Alcohol and Alcoholism
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JOURNAL ARTICLE
Dylan K Richards, Felicia R Tuchman, Kevin A Hallgren, Henry R Kranzler, Henri-Jean Aubin, Stephanie S O'Malley, Karl Mann, Arnie Aldridge, Raymond F Anton, Katie Witkiewitz
OBJECTIVES: This study aimed to evaluate the validity of World Health Organization (WHO) risk drinking level reductions as meaningful endpoints for clinical practice and research. This study examined whether such reductions were associated with a lower likelihood of a current alcohol use disorder (AUD) diagnosis and fewer AUD criteria. METHODS: We conducted a secondary data analysis to address these objectives using data from a multisite randomized controlled trial of gabapentin enacarbil extended release in treating moderate to severe AUD among adults (N = 346)...
April 12, 2024: Journal of Addiction Medicine
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JOURNAL ARTICLE
Marynold Purificacion, Roslina Binti Mohd Shah, Thierry De Meeûs, Saripah Binti Bakar, Anisah Bintil Savantil, Meriam Mohd Yusof, Divina Amalin, Hien Nguyen, Endang Sulistyowati, Aris Budiman, Arni Ekayanti, Jerome Niogret, Sophie Ravel, Marc J B Vreysen, Adly M M Abd-Alla
The cocoa pod borer (CPB) Conopomorpha cramerella (Snellen) (Lepidoptera: Gracillaridae) is one of the major constraints for cocoa production in South East Asia. In addition to cultural and chemical control methods, autocidal control tactics such as the Sterile Insect Technique (SIT) could be an efficient addition to the currently control strategy, however SIT implementation will depend on the population genetics of the targeted pest. The aim of the present work was to search for suitable microsatellite loci in the genome of CPB that is partially sequenced...
2024: PloS One
#13
JOURNAL ARTICLE
Andrea B Stefansdottir, Luis Vieira, Arni Johnsen, Daniel Isacson, Andres Rodriguez, Maria Mani
Background Perioperative management in autologous breast reconstruction has gained focus in recent years. This study compares two pain management protocols in patients undergoing abdominal-based free flap breast reconstruction: a past protocol (PP) and a current protocol (CP)-both intended to reduce opioid consumption postoperatively. The PP entails use of a pain catheter in the abdominal wound and the CP consists of an intraoperative nerve block in addition to refinements in the oral pain management...
March 2024: Archives of Plastic Surgery
#14
Victoria Palmer, Trie Arni Djunadi, Bhuvana Tantry, Angela Grigos
Cutaneous angiosarcoma is an aggressive tumor most commonly presenting on the head and neck. In this case report, we describe the presentation of sepsis secondary to an aggressive and rapidly expanding wound, located in a sun-protected area on the body, in a patient with multiple concurrent comorbidities. Treatment was tailored toward targeting the causative organisms, as well as identifying the histologic morphology of the pathologic legion. Histopathology and immunohistochemistry were used to confirm the diagnosis of cutaneous angiosarcoma, and the patient-centered decision surrounding palliative chemotherapy is outlined...
March 2024: Curēus
#15
REVIEW
Hiroaki Hiraiwa, Takahiro Okumura, Toyoaki Murohara
In this comprehensive state-of-the-art review, we provide an evidence-based analysis of current drug therapies for patients with heart failure with preserved ejection fraction (HFpEF) in the acute and chronic phases with concurrent hypertension. Additionally, we explore the latest developments and emerging evidence on the efficacy, safety, and clinical outcomes of common and novel drug treatments in the management of HFpEF with concurrent hypertension. During the acute phase of HFpEF, intravenous diuretics, mineralocorticoid receptor antagonists (MRAs), and vasodilators are pivotal, while in the chronic phase, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have proven effective in enhancing clinical outcomes...
April 4, 2024: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
#16
JOURNAL ARTICLE
Alexander Michel, Coralie Lecomte, Christoph Ohlmeier, Hanaya Raad, Frederike Basedow, Dennis Haeckl, Dominik Beier, Thomas Evers
BACKGROUND: Data are limited regarding guideline-directed medical therapy (GDMT) treatment patterns in patients with worsening heart failure (HF). METHODS: We used administrative claims databases in Germany and the USA to conduct a retrospective cohort study of patients with worsening HF. Two cohorts of patients with prevalent HF and a HF hospitalization (HFH) from 2016 to 2019, alive at discharge (N = 75,140 USA; N = 47,003 Germany) were identified. Index date was the first HFH during the study period...
April 4, 2024: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
#17
JOURNAL ARTICLE
Iván D Montoya, Colleen Watson, Arnie Aldridge, Danielle Ryan, Sean M Murphy, Brenda Amuchi, Kathryn E McCollister, Bruce R Schackman, Joshua L Bush, Drew Speer, Kristin Harlow, Stephen Orme, Gary A Zarkin, Mathieu Castry, Eric E Seiber, Joshua A Barocas, Benjamin P Linas, Laura E Starbird
BACKGROUND: Communities That HEAL (CTH) is a novel, data-driven community-engaged intervention designed to reduce opioid overdose deaths by increasing community engagement, adoption of an integrated set of evidence-based practices, and delivering a communications campaign across healthcare, behavioral-health, criminal-legal, and other community-based settings. The implementation of such a complex initiative requires up-front investments of time and other expenditures (i.e., start-up costs)...
April 2, 2024: Addiction Science & Clinical Practice
#18
JOURNAL ARTICLE
Lingling Zhang, Zhican Liu, Yunlong Zhu, Mingxin Wu, Haobo Huang, Wenbin Yang, Ke Peng, Jianping Zeng
BACKGROUND: Accurately predicting post-discharge mortality risk in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) remains a complex and critical challenge. The primary objective of this study was to develop and validate a robust risk prediction model to assess the 12-month and 24-month mortality risk in STEMI patients after hospital discharge. METHODS: A retrospective study was conducted on 664 STEMI patients who underwent PPCI at Xiangtan Central Hospital Chest Pain Center between 2020 and 2022...
March 30, 2024: Journal of Cardiothoracic Surgery
#19
JOURNAL ARTICLE
Juan Duarte Torres, Selim R Krim
PURPOSE OF REVIEW: Hypertension remains one of the most common clinical problems leading to significant posttransplant complications. This study reviews the pathophysiology of hypertension in the postcardiac transplant phase and provides an update on currently available antihypertensive therapies for heart transplant patients. RECENT FINDINGS: The true prevalence of hypertension in the heart transplant population remains unknown. Effective blood pressure (BP) control is key to prevent left ventricular remodeling, diastolic dysfunction and stroke...
March 28, 2024: Current Opinion in Cardiology
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JOURNAL ARTICLE
Arnis Strods, Karīna Narbute, Valērija Movčana, Kévin Gillois, Roberts Rimša, Patrik Hollos, Fēlikss Rūmnieks, Arnita Spule, Gatis Mozoļevskis, Arturs Abols
Organ-on-a-chip (OOC) is an innovative microfluidic device mimicking the structure and functionality of real tissue. OOCs typically involve cell culture with microfluidics to emulate the biological forces of different organ tissues and disease states, providing a next-generation experimental platform. When combined with simulated microgravity conditions, such as those produced by random positioning machines, they offer unique insights into disease processes. Microgravity has been shown to affect cellular behaviors, like proliferation and viability, though its influence on cell physiology is not fully explored...
March 9, 2024: Micromachines
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