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https://www.readbyqxmd.com/read/29145948/type-of-atrial-fibrillation-and-outcomes-in%C3%A2-patients-with-heart-failure-and-reduced%C3%A2-ejection%C3%A2-fraction
#1
Ulrik M Mogensen, Pardeep S Jhund, William T Abraham, Akshay S Desai, Kenneth Dickstein, Milton Packer, Jean L Rouleau, Scott D Solomon, Karl Swedberg, Michael R Zile, Lars Køber, John J V McMurray
BACKGROUND: Atrial fibrillation (AF) is common in heart failure (HF), but the outcome by type of AF is largely unknown. OBJECTIVES: This study investigated outcomes related to type of AF (paroxysmal, persistent or permanent, or new onset) in 2 recent large trials in patients with HF with reduced ejection fraction. METHODS: The study analyzed patients in the PARADIGM-HF (Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure) and ATMOSPHERE (Aliskiren Trial to Minimize Outcomes in Patients with Heart Failure) trials...
November 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29141857/contemporary-characteristics-and-outcomes-in-chagasic-heart-failure-compared-with-other-nonischemic-and-ischemic-cardiomyopathy
#2
Li Shen, Felix Ramires, Felipe Martinez, Luiz Carlos Bodanese, Luis Eduardo Echeverría, Efraín A Gómez, William T Abraham, Kenneth Dickstein, Lars Køber, Milton Packer, Jean L Rouleau, Scott D Solomon, Karl Swedberg, Michael R Zile, Pardeep S Jhund, Claudio R Gimpelewicz, John J V McMurray
BACKGROUND: Chagas' disease is an important cause of cardiomyopathy in Latin America. We aimed to compare clinical characteristics and outcomes in patients with heart failure (HF) with reduced ejection fraction caused by Chagas' disease, with other etiologies, in the era of modern HF therapies. METHODS AND RESULTS: This study included 2552 Latin American patients randomized in the PARADIGM-HF (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) and ATMOSPHERE (Aliskiren Trial to Minimize Outcomes in Patients With Heart Failure) trials...
November 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29098939/adsorption-of-inorganic-mercury-from-aqueous-solutions-onto-dry-biomass-of-chlorella-vulgaris-kinetic-and-isotherm-study
#3
Carlo Solisio, Saleh Al Arni, Attilio Converti
This study focused on kinetics and equilibrium isotherms of mercury biosorption from water using dry biomass of Chlorella vulgaris as biosorbent at pH 5.0. Biosorption tests were performed at 2.0 g/L biomass dosage varying initial Hg concentration from 11.0 to 90.6 mg/L. The Lagergren equation was found to best describe the process, with R(2) of 0.984 and specific rate constant of 0.029±0.004 min(-1). Although equilibrium data were well fitted by the Dubinin and Radushkevich isotherm (R(2) = 0.870; qDR = 16...
November 3, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29066613/severe-negative-energy-balance-during-21-d-at-high-altitude-decreases-fat-free-mass-regardless-of-dietary-protein-intake-a-randomized-controlled-trial
#4
Claire E Berryman, Andrew J Young, J Philip Karl, Robert W Kenefick, Lee M Margolis, Renee E Cole, John W Carbone, Harris R Lieberman, Il-Young Kim, Arny A Ferrando, Stefan M Pasiakos
In this 2-phase randomized controlled study, we examined whether consuming a higher protein (HP) diet would attenuate fat-free mass (FFM) loss during energy deficit (ED) at high altitude (HA) in 17 healthy males (mean ± sd: 23 ± 6 yr; 82 ± 14 kg). During phase 1 at sea level (SL, 55 m), participants consumed a eucaloric diet providing standard protein (SP; 1.0 g protein/kg,) for 21 d. During phase 2, participants resided at HA (4300 m) for 22 d and were randomly assigned to either an SP or HP (2.0 g protein/kg) diet designed to elicit a 40% ED...
October 24, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29066101/quality-of-meal-protein-determines-anabolic-response-in-older-adults
#5
Il-Young Kim, Yun-A Shin, Scott E Schutzler, Gohar Azhar, Robert R Wolfe, Arny A Ferrando
BACKGROUND & AIMS: It has been demonstrated that the relative content and profile of essential amino acids (EAA) play a determining role for stimulation of muscle protein synthesis (MPS) following intake of pure EAA or protein alone. METHODS: To test if this also holds in the context of mixed meals at both whole body and muscle levels, twelve older subjects (57-74 yrs) received primed continuous infusion of L-[ring-(2)H5]phenylalanine and L-[ring-(2)H2]tyrosine over a 9-h experimental period to determine whole body protein kinetics and MPS in the fasted state and following consumption of egg-based (EGG) or cereal-based (CEREAL) isocaloric and isonitrogenous breakfast...
October 6, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29060439/design-of-an-mhealth-system-for-maternal-and-children-hiv-care
#6
Allya P Koesoema, Arni Ariani, Yoke S Irawan, Soegijardjo Soegijoko
While progress has been made to slow down its spread and increase uptake of treatment, human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is still a highly significant health problem for many low- and middle-income countries (LMICs). Specifically, almost half of new HIV patients in Asia Pacific were children. The prevention of mother-to-child transmission faces complex socioeconomic and other problems. With the increasing growth of mobile technologies in LMICs, especially in Asia Pacific, mHealth, the application of mobile technology for health applications, has a significant potential to help alleviate these problems...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29053805/longitudinal-measures-of-deformation-are-associated-with-a-composite-measure-of-contractility-derived-from-pressure-volume-loop-analysis-in-children
#7
Shahryar M Chowdhury, Ryan J Butts, Carolyn L Taylor, Varsha M Bandisode, Karen S Chessa, Anthony M Hlavacek, Arni Nutting, Girish S Shirali, G Hamilton Baker
Aims: The relationship between echocardiographic measures of left ventricular (LV) systolic function and reference-standard measures have not been assessed in children. The objective of this study was to assess the validity of echocardiographic indices of LV systolic function via direct comparison to a novel composite measure of contractility derived from pressure-volume loop (PVL) analysis. Methods and results: Children with normal loading conditions undergoing routine left heart catheterization were prospectively enrolled...
June 29, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29048993/personalized-risk-prediction-in-clinical-oncology-research-applications-and-practical-issues-using-survival-trees-and-random-forests
#8
Chen Hu, Jon Arni Steingrimsson
A crucial component of making individualized treatment decisions is to accurately predict each patient's disease risk. In clinical oncology, disease risks are often measured through time-to-event data, such as overall survival and progression/recurrence-free survival, and are often subject to censoring. Risk prediction models based on recursive partitioning methods are becoming increasingly popular largely due to their ability to handle nonlinear relationships, higher-order interactions, and/or high-dimensional covariates...
October 19, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/29042280/biochemical-and-biophysical-characterization-of-a-mycoredoxin-protein-glutaredoxin-a1-from-corynebacterium-pseudotuberculosis
#9
Raphael J Eberle, Liege A Kawai, Fabio R de Moraes, Ljubica Tasic, Raghuvir K Arni, Monika A Coronado
Glutaredoxin A1 from Corynebacterium pseudotuberculosis was shown to be a mycoredoxin protein. In this study, we established a process to overexpress and purify glutaredoxin A1. The aim of this study was the investigation of the Glutaredoxin A1 from C. pseudotuberculosis behavior under different redox environments and the identification of lead molecules, which can be used for specific inhibitor development for this protein family. A quantitative assay was performed measuring the rate of insulin reduction spectrophotometrically at 640nm through turbidity formation from the precipitation of the free insulin...
October 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29038434/barley-six-rowed-spike3-encodes-a-putative-jumonji-c-type-h3k9me2-me3-demethylase-that-represses-lateral-spikelet-fertility
#10
Hazel Bull, M Cristina Casao, Monika Zwirek, Andrew J Flavell, William T B Thomas, Wenbin Guo, Runxuan Zhang, Paulo Rapazote-Flores, Stylianos Kyriakidis, Joanne Russell, Arnis Druka, Sarah M McKim, Robbie Waugh
The barley inflorescence (spike) comprises a multi-noded central stalk (rachis) with tri-partite clusters of uni-floretted spikelets attached alternately along its length. Relative fertility of lateral spikelets within each cluster leads to spikes with two or six rows of grain, or an intermediate morphology. Understanding the mechanisms controlling this key developmental step could provide novel solutions to enhanced grain yield. Classical genetic studies identified five major SIX-ROWED SPIKE (VRS) genes, with four now known to encode transcription factors...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29035983/injury-pattern-in-icelandic-elite-male-handball-players
#11
Elis Thor Rafnsson, Örnólfur Valdimarsson, Thorarinn Sveinsson, Árni Árnason
OBJECTIVE: To examine the incidence, type, location, and severity of injuries in Icelandic elite male handball players and compare across factors like physical characteristics and playing position. DESIGN: Prospective cohort study. SETTING: The latter part of the preseason and the competitive season of Icelandic male handball. PARTICIPANTS: Eleven handball teams (185 players) from the 2 highest divisions in Iceland participated in the study...
October 10, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29029636/gene-expression-modules-in-primary-breast-cancers-as-risk-factors-for-organotropic-patterns-of-first-metastatic-spread-a-case-control-study
#12
Katherine Lawler, Efterpi Papouli, Cristina Naceur-Lombardelli, Anca Mera, Kayleigh Ougham, Andrew Tutt, Siker Kimbung, Ingrid Hedenfalk, Jun Zhan, Hongquan Zhang, Richard Buus, Mitch Dowsett, Tony Ng, Sarah E Pinder, Peter Parker, Lars Holmberg, Cheryl E Gillett, Anita Grigoriadis, Arnie Purushotham
BACKGROUND: Metastases from primary breast cancers can involve single or multiple organs at metastatic disease diagnosis. Molecular risk factors for particular patterns of metastastic spread in a clinical population are limited. METHODS: A case-control design including 1357 primary breast cancers was used to study three distinct clinical patterns of metastasis, which occur within the first six months of metastatic disease: bone and visceral metasynchronous spread, bone-only, and visceral-only metastasis...
October 13, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29024353/exercise-and-physical-activity-for-patients-with-esld-improving-functional-status-and-sarcopenia-while-on-the-transplant-waitlist
#13
REVIEW
Andrés Duarte-Rojo, Astrid Ruiz-Margáin, Aldo J Montaño-Loza, Ricardo Macías-Rodríguez, Arny Ferrando, W Ray Kim
Sarcopenia and physical deconditioning are frequent complications in patients with cirrhosis and end-stage liver disease (ESLD). They are the end result of impaired dietary intake, chronic inflammation, altered macro- and micronutrient metabolism, and low physical activity. Frailty is the end result of prolonged sarcopenia and physical deconditioning. It severely affects a patient's functional status, and presents in about 1 in 5 patients on the liver transplant (LT) waitlist. Sarcopenia, poor physical fitness/cardiopulmonary endurance, and frailty are all associated with increased mortality in ESLD...
October 11, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29018174/prognostic-value-of-n-terminal-pro-b-type-natriuretic-peptide-levels-in-heart-failure-patients-with-and-without-atrial-fibrillation
#14
Søren Lund Kristensen, Pardeep S Jhund, Ulrik M Mogensen, Rasmus Rørth, William T Abraham, Akshay Desai, Kenneth Dickstein, Jean L Rouleau, Michael R Zile, Karl Swedberg, Milton Packer, Scott D Solomon, Lars Køber, John J V McMurray
BACKGROUND: Patients with heart failure (HF) and atrial fibrillation (AF) have higher circulating levels of NT-proBNP (N-terminal pro-B-type natriuretic peptide) than HF patients without AF. There is uncertainty about the prognostic importance of a given concentration of NT-proBNP in HF patients with and without AF. We investigated this question in a large cohort of patients with HF and reduced ejection fraction. METHODS AND RESULTS: We studied 14 737 patients with HF and reduced ejection fraction and a measurement of NT-proBNP at time of screening, enrolled in either the PARADIGM-HF trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) or the ATMOSPHERE trial (Aliskiren Trial to Minimize Outcomes in Patients With Heart Failure), of whom 3575 (24%) had AF on their baseline ECG...
October 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29017436/role-of-markov-modeling-approaches-to-understand-the-impact-of-infertility-treatments
#15
Arni S R Srinivasa Rao, Michael P Diamond
We are proposing to use Markov modeling type of analysis to understand data generated by treatments for infertility in women receiving ovarian stimulations. We describe the conceptual novelties, need for such an analysis, basics of the proposed methods, and theoretical constructions of various probabilities associated with practical level implementation of the Markov modeling procedures. This method can be adopted to infertility-related data visualizations whenever progression of outcome stages in infertility treatment is recorded...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28987926/set-size-manipulations-reveal-the-boundary-conditions-of-perceptual-ensemble-learning
#16
Andrey Chetverikov, Gianluca Campana, Árni Kristjánsson
Recent evidence suggests that observers can grasp patterns of feature variations in the environment with surprising efficiency. During visual search tasks where all distractors are randomly drawn from a certain distribution rather than all being homogeneous, observers are capable of learning highly complex statistical properties of distractor sets. After only a few trials (learning phase), the statistical properties of distributions - mean, variance and crucially, shape - can be learned, and these representations affect search during a subsequent test phase (Chetverikov, Campana, & Kristjánsson, 2016)...
October 16, 2017: Vision Research
https://www.readbyqxmd.com/read/28986012/effect-of-patient-choice-and-hospital-competition-on-service-configuration-and-technology-adoption-within-cancer-surgery-a-national-population-based-study
#17
Ajay Aggarwal, Daniel Lewis, Malcolm Mason, Arnie Purushotham, Richard Sullivan, Jan van der Meulen
BACKGROUND: There is a scarcity of evidence about the role of patient choice and hospital competition policies on surgical cancer services. Previous evidence has shown that patients are prepared to bypass their nearest cancer centre to receive surgery at more distant centres that better meet their needs. In this national, population-based study we investigated the effect of patient mobility and hospital competition on service configuration and technology adoption in the National Health Service (NHS) in England, using prostate cancer surgery as a model...
October 3, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28985871/ex%C3%A2-vivo-treatment-with-inhaled-n-acetylcysteine-in-porcine-lung-transplantation
#18
Yoshito Yamada, Ilker Iskender, Stephan Arni, Sven Hillinger, Tugba Cosgun, Keke Yu, Wolfgang Jungraithmayr, Nikola Cesarovic, Walter Weder, Ilhan Inci
BACKGROUND: We have shown the beneficial effects of N-acetylcysteine (NAC) on posttransplant lung function, when both donor and recipient were pretreated intravenously. However, systemic treatment of multiorgan donors may not be clinically relevant. Thus, we hypothesized that ex vivo treatment of donors with nebulized NAC would be adequate to prevent from ischemia-reperfusion injury after lung transplantation. METHODS: Lungs were retrieved from domestic pigs and stored at 4°C for 24 h followed by 2 h of ex vivo lung perfusion (EVLP) to administer 50 mg/kg of NAC via nebulization in the NAC group (n = 6)...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28978141/ex-vivo-multiplex-profiling-of-protein-tyrosine-kinase-activities-in-early-stages-of-human-lung-adenocarcinoma
#19
Stephan Arni, Thi Hong Nhung Le, Rik de Wijn, Refugio Garcia-Villegas, Martjin Dankers, Walter Weder, Sven Hillinger
Despite constant improvement in existing therapeutic efforts, the overall survival rate of lung cancer patients remains low. Enzyme activities may identify new therapeutically targetable biomarkers and overcome the marked lack of correlation between cellular abundance of translated proteins and corresponding mRNA expression levels. We analysed tyrosine kinase activities to classify lung adenocarcinoma (LuAdCa) resection specimens based on their underlying changes in cellular processes and pathways that are agents of or result from malignant transformation...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28920578/participation-in-physical-and-sportive-activities-among-adult-turkish-people-with-haemophilia-a-single-centre-experience
#20
Arni Lehmeier, Muhlis Cem Ar, Sevil Sadri, Mehmet Yürüyen, Zafer Başlar
No abstract text is available yet for this article.
September 18, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
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