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https://www.readbyqxmd.com/read/28528902/x-cells-are-globally-distributed-genetically-divergent-fish-parasites-related-to-perkinsids-and-dinoflagellates
#1
Mark A Freeman, Janina Fuss, Árni Kristmundsson, Marit F M Bjorbækmo, Jean-François Mangot, Javier Del Campo, Patrick J Keeling, Kamran Shalchian-Tabrizi, David Bass
"X-cells" have long been associated with tumor-like formations (xenomas) in marine fish, including many of commercial interest. The name was first used to refer to the large polygonal cells that were found in epidermal xenomas from flatfish from the Pacific Northwest [1]. Similar looking cells from pseudobranchial xenomas had previously been reported from cod in the Atlantic [2] and Pacific Oceans [3]. X-cell pathologies have been reported from five teleost orders: Pleuronectiformes (flatfish), Perciformes (perch-like fish), Gadiformes (cods), Siluriformes (catfish), and Salmoniformes (salmonids)...
May 13, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28528433/hydrolysis-of-phosphatidylcholine-isoprostanes-ptdcho-ip-by-peripheral-human-group-iia-v-and-x-secretory-phospholipases-a2-spla2
#2
Arnis Kuksis, Waldemar Pruzanski
Biologically active F- and E/D-type-prostane ring isomers (F2-IP and E2/D2-IP, respectively) are produced in situ by non-enzymatic peroxidation of arachidonic acid esterified to GroPCho (PtdCho-IP) and are universally distributed in tissue lipoproteins and cell membranes. Previous work has shown that platelet-activating factor acetylhydrolases (PAF-AH) are the main endogenous PLA2 involved in degradation of PtdCho-IP. The present study shows that the PtdCho-IP are also subject to hydrolysis by group IIA, V and X secretory PLA2, which also have a wide peripheral tissue distribution...
May 20, 2017: Lipids
https://www.readbyqxmd.com/read/28520449/-novelties-in-the-treatment-of-heart-failure
#3
Filip Souček, Jan Novak
Heart failure (HF) is a complex clinical syndrome which is manifested by characteristic symptoms and objective signs of cardiac insufficiency. The incidence of HF, particularly its chronic form, is estimated 0.4-2 % in the central and western Europe, with an increase in higher age groups, affecting 10-20 % of the population aged over 80. With respect to its growing incidence and prevalence, novel modalities of pharmacological and non-pharmacological treatment are being developed in order to improve quality of life and survival of the affected patients...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28512738/first-in-class-composite-angiotensin-receptor-neprilysin-inhibitors-arni-in-practice
#4
REVIEW
Maya H Barghash, Akshay S Desai
No abstract text is available yet for this article.
May 16, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28504994/preoperative-low-dose-aspirin-exposure-and-outcomes-after-emergency-neurosurgery-for-traumatic-intracranial-hemorrhage-in-elderly-patients
#5
Alex T Lee, Arni Gagnidze, Sharon R Pan, Pimwan Sookplung, Bala Nair, Shu-Fang Newman, Alon Ben-Ari, Ahmed Zaky, Kevin Cain, Monica S Vavilala, Irene Rozet
BACKGROUND: Antiplatelet medications are usually discontinued before elective neurosurgery, but this is not an option for emergent neurosurgery. We performed a retrospective cohort study to examine whether preoperative aspirin use was associated with worse outcomes after emergency neurosurgery in elderly patients. METHODS: We analyzed all cases of emergency neurosurgical procedures for traumatic intracranial hemorrhage from 2008 to 2012 at a level 1 trauma center...
May 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28500017/tablet-based-well-being-check-for-the-elderly-development-and-evaluation-of-usability-and-acceptability
#6
Pradeep Ray, Junhua Li, Arni Ariani, Vasvi Kapadia
BACKGROUND: Many elderly people prefer to live at home independently. One of the major concerns raised by the family members is the safety and well-being of their elderly family members when living independently in a home environment. To address this issue, assistive technology solutions have been available in the market. Despite their availability and proliferation, these types of solutions are not popular with the elderly due to their intrusive nature, privacy-related issues, social stigma, and fear of losing human interaction...
May 12, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28489317/pharmacogenomics-of-angiotensin-receptor-neprilysin-inhibitor-and-its-long-term-side-effects
#7
REVIEW
Chayakrit Krittanawong, Takeshi Kitai
The development of the promising agent sacubitril/valsartan, known as an angiotensin receptor blocker-neprilysin inhibitor (ARNI), to improve heart failure (HF) management, may benefit morbidity, mortality, and readmission rates in patients with HF. The PARADIGM-HF trial demonstrated that the ARNI can reduce morbidity and mortality in patients with heart failure with reduced ejection fraction (HFrEF), while ongoing PARAMOUNT and PARAGON-HF trials determined whether the ARNI has morbidity and mortality benefits in patients with heart failure with preserved ejection fraction (HFpEF)...
May 10, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28489009/-vanishing-lungs-a-case-report
#8
Thorunn Halldora Thordardottir, Arni Jon Geirsson, Sif Hansdottir
A 55 year old female with rheumatoid arthritis who was repeatedly admitted to internal medicine for fever, shortness of breath and pleuritic chest pain. Laboratory work up showed normal WBC but elevated CRP and sedimentatation rate. Cultures were negative. Imaging studies revealed elevated diaphragms, bilateral atelectasis and pleural fluid but normal lung parenchyma. Lung function testing showed restriction. Anti-dsDNA and anti-Ro/SSA were elevated. A clinical diagnosis of anti-TNF-induced lupus secondary to infliximab and shrinking lung syndrome was made...
May 2017: Læknablađiđ
https://www.readbyqxmd.com/read/28464620/effects-of-stimulus-order-on-auditory-distance-discrimination-of-virtual-nearby-sound-sources
#9
Simone Spagnol, Rebekka Hoffmann, Árni Kristjánsson, Federico Avanzini
Stimulus order has been reported to affect perceived loudness. This letter investigates how temporal order affects distance discrimination of receding and approaching pairs of sound sources rendered binaurally in the anechoic near-field. Individual discrimination thresholds for different virtual locations were measured through an adaptive procedure. The threshold values show a bias toward approaching stimuli for closer reference distances (≤50 cm) and toward receding stimuli for farther reference distances (100 cm), but only when absolute intensity cues are available...
April 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28460827/heart-failure
#10
REVIEW
Marco Metra, John R Teerlink
Heart failure is common in adults, accounting for substantial morbidity and mortality worldwide. Its prevalence is increasing because of ageing of the population and improved treatment of acute cardiovascular events, despite the efficacy of many therapies for patients with heart failure with reduced ejection fraction, such as angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), β blockers, and mineralocorticoid receptor antagonists, and advanced device therapies. Combined angiotensin receptor blocker neprilysin inhibitors (ARNIs) have been associated with improvements in hospital admissions and mortality from heart failure compared with enalapril, and guidelines now recommend substitution of ACE inhibitors or ARBs with ARNIs in appropriate patients...
April 28, 2017: Lancet
https://www.readbyqxmd.com/read/28451908/arny-demain
#11
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28451907/on-being-an-honorary-member-of-arny-s-army-some-musings-about-fungal-fermentations-secondary-metabolism-and-scientific-communities
#12
Joan Wennstrom Bennett
This essay is an unabashed celebration of applied microbiology and secondary metabolism, and how one scientist-Arnold Demain-has been a spokesman for industrial microbiology and biotechnology. There are many reasons for Arny's professional success. During his long and distinguished career, Arnold Demain has expanded and enriched our understanding of the importance secondary metabolism. He has studied topics that ranged from pickles, to pectinolytic enzymes, to penicillin. His experimental versatility was conducted under the unifying theme of fermentation microbiology...
May 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28432703/selective-calixarene-directed-synthesis-of-mxene-plates-crumpled-sheets-spheres-and-scrolls
#13
Arni Vaughn, Jeremy Ball, Tobias Heil, David Morgan, Giulio Lampronti, Gabija Maršalkaitė, Colin L Raston, Nicholas P Power, Suela Kellici
Fully exploiting the electronic and mechanical properties of 2D laminar materials not only requires efficient and effective means of their exfoliation into low dimensional layers, but also necessitates a means of changing their morphology so as to explore any enhancement that this may offer. MXenes are a rapidly emerging new class of such laminar materials with unique properties. However, access to other morphologies of MXenes has not yet been fully realised. To this end we have developed the synthesis of MXenes (Ti2C) as plates, crumpled sheets, spheres and scrolls, which involves selective intercalation of p-phosphonic calix[n]arenes, with control in morphology arising from the choice of the size of the macrocycle, n = 4, 5, 6 or 8...
April 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28419972/neprilysin-inhibitors-a-new-hope-to-halt-the-diabetic-cardiovascular-and-renal-complications
#14
REVIEW
Vajir Malek, Anil Bhanudas Gaikwad
Diabetes is an enormous and ever-growing calamity and a global public health threat of the 21st century. Besides insulin and oral hypoglycaemic drugs, blockage of the renin-angiotensin system (RAS) denotes a key pharmacotherapy for the management of cardiovascular (CVD) and chronic kidney diseases (CKD), which are the leading causes of disability and death among diabetic patients. Neprilysin (NEP) inhibition, auxiliary to RAS blockage increases the bioavailability of natriuretic peptides and benefits the cardio-renal system...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28405777/how-visual-working-memory-contents-influence-priming-of-visual-attention
#15
Nancy B Carlisle, Árni Kristjánsson
Recent evidence shows that when the contents of visual working memory overlap with targets and distractors in a pop-out search task, intertrial priming is inhibited (Kristjánsson, Sævarsson & Driver, Psychon Bull Rev 20(3):514-521, 2013, Experiment 2, Psychonomic Bulletin and Review). This may reflect an interesting interaction between implicit short-term memory-thought to underlie intertrial priming-and explicit visual working memory. Evidence from a non-pop-out search task suggests that it may specifically be holding distractors in visual working memory that disrupts intertrial priming (Cunningham & Egeth, Psychol Sci 27(4):476-485, 2016, Experiment 2, Psychological Science)...
April 12, 2017: Psychological Research
https://www.readbyqxmd.com/read/28401875/-tumors-of-unknown-origin-case-report
#16
Arni Jon Geirsson, Sigridur Thordis Valtysdottir, Andres Sigvaldason, Margret Sigurdardottir
IgG4 related disease is a recently recognized chronic fibrotic, inflammatory condition, caused by infiltrating IgG4 positive plasma cells that can cause tumor like disease in almost any organ in the body. Typical histopathology is lymphoplasmocytic infiltration of IgG4 positive cells, storiform fibrosis and obliterative phlebitis. Glucocorticoids alone or in combination with B-cell depletion with rituximab causes often good, lasting response. We present here a lady with recurrent lung infiltration that simulated pneumonia and later tumor of the lung...
April 2017: Læknablađiđ
https://www.readbyqxmd.com/read/28385919/supplementing-an-energy-adequate-higher-protein-diet-with-protein-does-not-enhance-fat-free-mass-restoration-after-short-term-severe-negative-energy-balance
#17
Claire E Berryman, John J Sepowitz, Holly L McClung, Harris R Lieberman, Emily K Farina, James P McClung, Arny A Ferrando, Stefan M Pasiakos
Negative energy balance during military operations can be severe and result in significant reductions in fat-free mass (FFM). Consuming supplemental high-quality protein following such military operations may accelerate restoration of FFM. Body composition (dual-energy x-ray absorptiometry) and whole-body protein turnover (single-pool (15)N-alanine method) were determined before (PRE) and after 7 d (POST) of severe negative energy balance during military training in 63 male US Marines (mean±SD, 25±3 y, 84±9 kg)...
April 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28377626/problems-with-visual-statistical-learning-in-developmental-dyslexia
#18
Heida Maria Sigurdardottir, Hilda Bjork Danielsdottir, Margret Gudmundsdottir, Kristjan Helgi Hjartarson, Elin Astros Thorarinsdottir, Árni Kristjánsson
Previous research shows that dyslexic readers are impaired in their recognition of faces and other complex objects, and show hypoactivation in ventral visual stream regions that support word and object recognition. Responses of these brain regions are shaped by visual statistical learning. If such learning is compromised, people should be less sensitive to statistically likely feature combinations in words and other objects, and impaired visual word and object recognition should be expected. We therefore tested whether people with dyslexia showed diminished capability for visual statistical learning...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28359417/early-adoption-of-sacubitril-valsartan-for-patients-with-heart-failure-with-reduced-ejection-fraction-insights-from-get-with-the-guidelines-heart-failure-gwtg-hf
#19
Nancy Luo, Gregg C Fonarow, Steven J Lippmann, Xiaojuan Mi, Paul A Heidenreich, Clyde W Yancy, Melissa A Greiner, Bradley G Hammill, N Chantelle Hardy, Stuart J Turner, Warren K Laskey, Lesley H Curtis, Adrian F Hernandez, Robert J Mentz, Emily C O'Brien
OBJECTIVES: The aim of this study was to assess the prevalence and variation in angiotensin receptor/neprilysin inhibitor (ARNI) prescription among a real-world population with heart failure with reduced ejection fraction (HFrEF). BACKGROUND: The U.S. Food and Drug Administration approved sacubitril/valsartan for patients with HFrEF in July 2015. Little is known about the early patterns of use of this novel therapy. METHODS: The study included patients discharged alive from hospitals in Get With the Guidelines-Heart Failure (GWTG-HF), a registry of hospitalized patients with heart failure, between July 2015 and June 2016 who had documentation of whether ARNIs were prescribed at discharge...
April 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28357089/chromothripsis-and-progression-free-survival-in-metastatic-colorectal-cancer
#20
Elina Skuja, Dagnija Kalniete, Miki Nakazawa-Miklasevica, Zanda Daneberga, Arnis Abolins, Gunta Purkalne, Edvins Miklasevics
Metastatic dissemination of the primary tumor is the major cause of death in colorectal cancer (CRC) patients. Multiple chromosomal breaks and chromothripsis, a phenomenon involving multiple chromosomal fragmentations occurring in a single catastrophic event, are associated with cancer genesis, progression and developing of metastases. The aim of this study was to evaluate the effect of chromothripsis and total breakpoint count (breakpoint instability index) on progression-free survival (PFS). A total of 19 patients with metastatic CRC (mCRC) receiving FOLFOX first-line palliative chemotherapy between August, 2011 and October, 2012 were selected for this study...
February 2017: Molecular and Clinical Oncology
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