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https://www.readbyqxmd.com/read/29028285/trends-in-the-incidence-rate-type-and-treatment-of-surgically-verified-endometriosis-a-nationwide-cohort-study
#1
Liisu Saavalainen, Tuulia Tikka, Anna But, Mika Gissler, Jari Haukka, Aila Tiitinen, Päivi Härkki, Oskari Heikinheimo
To study the trends in incidence rate, type and surgical treatment, and patient characteristics of surgically verified endometriosis during 1987-2012 MATERIAL AND METHODS: This is a register-based cohort study. We identified women receiving their first diagnosis of endometriosis in surgery from the Finnish Hospital Discharge Register (FHDR). Quality of the FHDR records was assessed bidirectionally. The age-standardized incidence rates of the first surgically verified endometriosis was assessed by calendar year RESULTS: The cohort comprises 49 956 women...
October 13, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29027327/laparoscopic-ventral-hernia-repair-using-only-5-mm-ports
#2
Nicholas Bell-Allen, Harriet O'Rourke, Lisa Hong, Nicholas O'Rourke
BACKGROUND: The technique of laparoscopic ventral hernia repair has been evolving since it was first described over 20 years ago. We report a new technique where polyester mesh was back loaded through a 5-mm port site, coming into contact with the skin. This avoids the need for any 10-12-mm ports. METHODS: A prospective database of laparoscopic ventral hernia repairs was examined. A single surgeon performed 344 laparoscopic ventral hernia repairs using this technique over 60 months...
October 12, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29019814/the-optimization-of-the-prevascularization-procedures-for-improving-subcutaneous-islet-engraftment
#3
Satomi Suzuki Uematsu, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Yasuhiro Igarashi, Ibrahim Fathi, Shigehito Miyagi, Noriaki Ohuchi, Susumu Satomi, Masafumi Goto
BACKGROUND: Subcutaneous islet transplantation (SC Tx) is associated with minimal invasiveness, but poor vascularization. Thus, the optimization of the prevascularization procedures is crucial for improving the outcomes. Although the effectiveness of basic fibroblast growth factor (bFGF) was reported, the optimal procedures remain unclear. We sought to optimize the prevascularization procedures including the use of a novel scaffold, recombinant peptide (RCP). METHODS: Devices containing various amount of bFGF with/without heparin, or RCP were implanted into the subcutaneous space of diabetic C57BL/6 mice...
October 10, 2017: Transplantation
https://www.readbyqxmd.com/read/29019556/comparative-study-of-postoperative-pain-between-the-lichtenstein-and-laparoscopy-surgical-techniques-for-the-treatment-of-unilateral-primary-inguinal-hernia
#4
Leandro Mendonça Pedroso, Renato Miranda DE-Melo, Nelson Jorge DA-Silva-Jr
BACKGROUND: There are several surgical treatment options for inguinal hernia; however, there is no consensus on the literature identifying which surgical technique promotes less postoperative pain. AIM: To compare the intensity of postoperative pain between the surgical techniques Lichtenstein and transabdominal pre-peritoneal laparoscopy for the treatment of unilateral primary inguinal hernia. METHODS: Were included 60 patients, of which 30 were operated through the Lichtenstein technique and 30 patients through the transabdominal pre-peritoneal laparoscopy...
July 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/29019111/institutional-experience-with-ostomies-created-during-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemoperfusion
#5
Sam Pakraftar, Lekshmi Ramalingam, Yongli Shuai, Heather L Jones, James F Pingpank, Steven S Ahrendt, Matthew P Holtzman, Amer H Zureikat, Herbert J Zeh, David L Bartlett, Haroon A Choudry
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion (CRS-HIPEC) is a complex procedure that often requires ostomy creation to protect high-risk anastomoses. This study aimed to evaluate the authors' institutional experience with CRS-HIPEC-associated ostomies, determine predictors of ostomy creation and reversal, and assess their impact on survival. METHODS: The study analyzed clinicopathologic, perioperative, and oncologic data from a prospective database of 1435 CRS-HIPEC procedures for peritoneal metastases...
October 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29018838/adverse-post-operative-outcomes-in-jehovah-s-witnesses-with-gynecologic-cancer-within-30%C3%A2-days-of-surgery-a-single-institution-review-of-36-cases
#6
Laura J Moulton, Peter G Rose, Haider Mahdi
Rates of blood transfusion are reported as high as 32% in women undergoing major gynecologic cancer surgery. Therefore, care of the gynecologic oncology patient who refuses blood products, such as Jehovah's witnesses, can pose a unique challenge. The objective of this study was to determine rate of adverse post-operative outcomes within 30 days of surgery in Jehovah's witnesses with gynecologic cancer. This was a retrospective cohort study of Jehovah's witnesses undergoing laparotomy or minimally invasive surgery (MIS) for gynecologic cancer at a single institution...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29017824/early-postoperative-intraperitoneal-chemotherapy-is-associated-with-survival-benefit-for-appendiceal-adenocarcinoma-with-peritoneal-dissemination
#7
Yeqian Huang, Nayef A Alzahrani, Winston Liauw, Hussein Soudy, Abdulaziz M Alzahrani, David L Morris
INTRODUCTION: The combined approach of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has achieved encouraging outcomes for patients with PMCA with peritoneal dissemination. However, there is little evidence for the use of EPIC in addition to HIPEC in this group of patients. PATIENTS AND METHODS: This was a retrospective study of prospectively collected data of consecutive patients with PMCA who underwent CRS and perioperative intraperitoneal chemotherapy by one surgical team at St George Hospital in Sydney, Australia between Jan 1996 and Aug 2016...
September 28, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29017004/eating-frequency-predicts-changes-in-regional-body-fat-distribution-in-healthy-adults
#8
G Georgiopoulos, K Karatzi, M Yannakoulia, E Georgousopoulou, E Efthimiou, A Mareti, I Bakogianni, A Mitrakou, C Papamichael, K Stamatelopoulos
Background: Eating frequency (EF) has been associated with generalized obesity. Aim: We aimed to prospectively investigate potential associations of frequency of eating episodes with regional fat layers. Design: EF was evaluated at baseline in 115 subjects free of clinically overt cardiovascular disease (54 ± 9.1 years, 70 women) in a prospective, observational study. Methods: Metabolic parameters known to be associated with dietary factors and anthropometric markers including ultrasound assessment of subcutaneous (Smin) and pre-peritoneal (Pmax) fat and their ratio Smin/Pmax (AFI) were evaluated at baseline and at follow-up, 5 years later...
June 21, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28993690/spred2-deficiecy-protects-mice-from-polymicrobial-septic-peritonitis-by-enhancing-inflammation-and-bacterial-clearance
#9
Junya Itakura, Miwa Sato, Toshihiro Ito, Megumi Mino, Soichiro Fushimi, Sakuma Takahashi, Teizo Yoshimura, Akihiro Matsukawa
Sepsis is an infection-induced systemic inflammatory syndrome and a major cause of death for critically ill patients. Here, we examined whether the absence of Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, influences host defense against polymicrobial sepsis (PMS) induced by cecal ligation and puncture (CLP). Compared to wild-type mice, Spred2(-/-) mice exhibited higher survival rates with increased level of leukocyte infiltration and local chemokine production and reduced plasma and peritoneal bacterial loads after CLP...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28992134/risk-of-new-onset-diabetes-in-end-stage-renal-disease-patients-undergoing-dialysis-analysis-from-registry-data-of-taiwan
#10
I-Kuan Wang, Cheng-Li Lin, Hung-Chih Chen, Shih-Yi Lin, Chiz-Tzung Chang, Tzung-Hai Yen, Fung-Chang Sung
Background: This study compared the risk of developing new-onset diabetes between hemodialysis (HD) and peritoneal dialysis (PD) patients. We further investigated the effectiveness of icodextrin in reducing the risk of new-onset diabetes in PD patients. Methods: From the Taiwan health insurance database, 36 879 incident HD patients and 6382 incident PD patients from 2000 to 2010 were identified as study cohorts. We further selected an additional HD cohort matched by propensity scores (PSs) of PD patients...
August 10, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28991079/peritoneal-involvement-is-more-common-than-nodal-involvement-in-patients-with-high-grade-appendix-tumors-who-are-undergoing-prophylactic-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#11
Akash Mehta, Rohin Mittal, Kandiah Chandrakumaran, Norman Carr, Sanjeev Dayal, Faheez Mohamed, Brendan Moran, Tom Cecil
BACKGROUND: Right hemicolectomy is routinely recommended in patients with histologic findings of high-grade appendix tumors after appendicectomy. Undetected peritoneal disease may be encountered at surgery. In high-grade appendix tumors with disease detected radiologically, complete cytoreduction may not be possible and outcomes poor. For these reasons, we adopted a policy of prophylactic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. OBJECTIVE: The purpose of this study was to quantify the rates of peritoneal and nodal metastatic disease in patients with high-grade appendix tumors without obvious metastatic disease and to report the long-term outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in these patients...
November 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28989919/the-efficacy-and-safety-of-pegylated-liposomal-doxorubicin-monotherapy-and-combination-therapy-with-carboplatin-in-korean-patients-with-recurrent-ovarian-fallopian-tube-or-primary-peritoneal-cancer-a-single-institution-experience
#12
Young-Jae Lee, Yong-Man Kim, Shin-Wha Lee, Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Young-Tak Kim, Joo-Hyun Nam
OBJECTIVE: This study aimed to evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD) with or without carboplatin in Korean patients with recurrent ovarian cancer (ROC), fallopian tube, or primary peritoneal cancer. METHODS: This retrospective study included 52 patients with ROC, fallopian tube, or primary peritoneal cancer who received PLD (50 mg/m(2)) between 1(st) December 2014 and 31(th) July 2016. RESULTS: The mean number of chemotherapy cycles was 3...
September 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28988116/macrophage-c-type-lectin-is-essential-for-phagosome-maturation-and-acidification-during-escherichia-coli-induced-peritonitis
#13
Wook-Bin Lee, Ji-Jing Yan, Ji-Seon Kang, Lark Kyun Kim, Young-Joon Kim
Sepsis is a life-threatening condition caused by an uncontrolled response to bacterial infection. Impaired bactericidal activity in the host is directly associated with severe sepsis; however, the underlying regulatory mechanism(s) is largely unknown. Here, we show that MCL (macrophage C-type lectin) plays a crucial role in killing bacteria during Escherichia coli-induced peritonitis. MCL-deficient mice with E. coli-induced sepsis showed lower survival rates and reduced bacterial clearance when compared with control mice, despite similar levels of proinflammatory cytokine production...
October 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28985855/safety-of-perioperative-ketorolac-administration-in-pediatric-appendectomy
#14
Hibbut-Ur-Rauf Naseem, Robert Michael Dorman, George Ventro, David H Rothstein, Kaveh Vali
BACKGROUND: Recent studies in adults undergoing gastrointestinal surgeries show an increased rate of complications with the use of ketorolac. This calls into question the safety of ketorolac in certain procedures. We sought to evaluate the impact of perioperative ketorolac administration on outcomes in pediatric appendectomy. METHODS: The Pediatric Health Information System database was queried for patients aged 5-17 y with a primary diagnosis of appendicitis and a primary procedure of appendectomy during the period 2010-2014...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28985839/peritoneal-drainage-is-associated-with-higher-survival-rates-for-necrotizing-enterocolitis-in-premature-extremely-low-birth-weight-infants
#15
Jun Tashiro, Amy E Wagenaar, Eduardo A Perez, Juan E Sola
BACKGROUND: To evaluate peritoneal drainage (PD) and laparotomy ± resection/ostomy (LAP) as initial approaches to the surgical management of necrotizing enterocolitis (NEC) in premature, extremely low birth weight (ELBW) infants. METHODS: Kids' Inpatient Database (2003-2012) was searched for cases of NEC (International Classification of Diseases, ninth revision, Clinical Modification [ICD-9-CM] 777.5x) in premature (<37 weeks), extremely low birth weight (<1000 g) infants...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28984812/factors-associated-with-diffusely-increased-renal-uptake-of-tc-99m-diphosphono-propanedicarboxylic-acid-on-bone-scintigraphy-in-patients-with-end-stage-renal-disease
#16
Keunyoung Kim, Seong-Jang Kim, Sang H Song, In-Joo Kim, Kyoungjune Pak, So J Kim, Senghyeon Shin, Bum S Kim
OBJECTIVE: We aimed to determine the factors contributing toward diffusely increased renal uptake on bone scintigraphy using technetium-99m (Tc-99m) diphosphono-propanedicarboxylic acid (DPD) in patients with end-stage renal disease. PATIENTS AND METHODS: One-hundred and forty-three bone scintigraphies, performed between June 2007 and July 2013, in 135 patients with chronic kidney disease were analyzed retrospectively, including 22 bone scintigraphies (15 patients; eight women; seven men) with glomerular filtration rates less than 15 ml/min/1...
October 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28983956/transitional-dialysis-care-units-a-new-approach-to-increase-home-dialysis-modality-uptake-and-patient-outcomes
#17
REVIEW
José A Morfín, Alex Yang, Elizabeth Wang, Brigitte Schiller
Home hemodialysis (HHD) and peritoneal dialysis (PD) are associated with better clinical outcomes, lower hospitalization rates, and improved quality of life compared with conventional in-center hemodialysis. However, <12% of patients requiring dialysis therapy use HHD or PD in the United States, even though over 90% of nephrologists would choose home-based dialysis modalities for themselves. Inadequate patient education and decision-making support are key barriers to patients choosing home-based therapy...
October 5, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28981543/bacterial-colonization-patterns-in-daily-chlorhexidine-care-at-the-exit-site-in-peritoneal-dialysis-patients-a-prospective-randomized-controlled-trial
#18
Hsi-Hao Wang, Shih-Yuan Hung, Min-Yu Chang, Yi-Che Lee, Hsiu-Fang Lin, Tsun-Mei Lin, Su-Pen Yang, Hsi-Hsun Lin, Su-Ching Yang, Jiun-Ling Wang
Bacterial colonization patterns in daily chlorhexidine care at the exit site in peritoneal dialysis (PD) patients were not known. We performed a prospective, randomized controlled trial enrolling 89 PD patients. After stratification by initial Staphylococcus aureus (SA) carrier status, patients were randomly assigned to receive daily 4% chlorhexidine care (intervention group) or normal saline (control group) at the exit site. Monthly, we cultured bacteria from the exit site and nasal swabs for 1 year. The SA colonization rates at exit site at 6 and 12 months were significantly lower in the intervention group than the control group (5...
2017: PloS One
https://www.readbyqxmd.com/read/28980179/cross-sectional-location-of-gastric-cancer-affects-the-long-term-survival-of-patients-as-tumor-invasion-deepens
#19
Yoon Ju Jung, Ho Seok Seo, Ji Hyun Kim, Cho Hyun Park, Han Hong Lee
BACKGROUND: The prognosis of gastric cancer is generally determined by tumor depth and lymph node metastasis, while the effect of cross-sectional tumor location on prognosis remains unclear. METHODS: This study recruited patients who had been diagnosed with gastric cancer and who underwent gastrectomy from 1989 to 2012. The cross-sectional locations of the gastric cancers were classified into four regions: the lesser (LC) and greater curvatures (GC), and anterior (AW) and posterior walls (PW)...
October 4, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28978552/tryptophan-derived-3-hydroxyanthranilic-acid-contributes-to-angiotensin-ii-induced-abdominal-aortic-aneurysm-formation-in-mice-in-vivo
#20
Qiongxin Wang, Ye Ding, Ping Song, Huaiping Zhu, Imoh S Okon, Nan-Yang Ding, Houzao Chen, Depei Liu, Ming-Hui Zou
Background -Abnormal amino acid metabolism is associated with vascular disease. However, the causative link between dysregulated tryptophan metabolism and abdominal aortic aneurysm (AAA) is unknown. Methods -Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism. Mice with deficiencies in both apolipoprotein e (Apoe) and IDO (Apoe(-/-)/IDO(-/-)) were generated by cross-breeding IDO(-/-) mice with Apoe(-/-) mice. Results -The acute infusion of angiotensin II (AngII) markedly increased the incidence of AAA in Apoe(-/-) mice, but not in Apoe(-/-)/IDO(-/-) mice, which presented decreased elastic lamina degradation and aortic expansion...
October 4, 2017: Circulation
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