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Biliary injury

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https://www.readbyqxmd.com/read/29032604/the-impact-of-inter-center-sharing-on-the-outcomes-of-pediatric-split-liver-transplantation
#1
Ahmed M Elsabbagh, Cassie Williams, Raffaele Girlanda, Jason Hawksworth, Alexander Kroemer, Cal S Matsumoto, Thomas M Fishbein
BACKGROUND: Split liver transplantation allows for expansion of the pool of organs available for pediatric liver transplantation. The impact of sharing segments of the same liver between centers has not been studied. STUDY DESIGN: Retrospective analysis of 24 pediatric split liver transplant cases in a recent cohort. We evaluated the outcomes of pediatric recipients who shared organs with adult patients in our own center (group A) compared to recipients who shared organs with adult patients in other centers...
October 15, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29031964/-the-thoracic-surgeon-and-the-management-of-the-bronchial-biliary-fistula-of-hydatid-origin
#2
S Rabiou, L Belliraj, F Z Ammor, I Issoufou, B Sylla, M Lakranbi, Y Ouadnouni, D Benajah, M Smahi
INTRODUCTION: The bronchial biliary fistula surgery is a major one, always going with a higher rate of complication especially in case of bile duct obstruction. The aim of this study is to find out the contribution of endoscopic sphincterotomy while reporting the results of surgical treatment of bronchial biliary fistulae by exclusive thoracotomy. METHODS: This was a retrospective study, which took place in the Department of Thoracic Surgery, University Hospital Hassan II, from January 2009 to March 2016...
October 12, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29025383/repair-of-bile-duct-injury-with-autologous-vein-graft-and-stent
#3
Bin Xie, Haiping Luo, Xinglong Yang, Yanping Zhao, Chongwu He, Xiaobin Wan, Zhitao Xu, Xingwei Yu, Wubo Liu, Qiang Liu
OBJECTIVES: We investigated the effects of autologous vein transplant on bile duct injury repair, through observation of the hepatic and biliary system tissue morphology changes and animal survival after bile duct injury repair. MATERIALS AND METHODS: Rabbits were equally divided into groups. Group A had cholecystectomy and common bile duct resection (length of 0.5 cm), transplant of an autologous vein (length of 0.5 cm), and stent implant. Group B had cholecystectomy and common bile duct resection (length of 1...
October 12, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29024427/combined-liver-kidney-perfusion-enhances-protective-effects-of-normothermic-perfusion-on-livers-grafts-from-donation-after-cardiac-death
#4
Xiaoshun He, Fei Ji, Zhiheng Zhang, Yunhua Tang, Lu Yang, Shanzhou Huang, Wenwen Li, Qiao Su, Wei Xiong, Zebin Zhu, Linhe Wang, Lei Lv, Jiyou Yao, Linan Zhang, Longjuan Zhang, Zhiyong Guo
It has been showed that combined liver-kidney normothermic machine perfusion (NMP) is able to better maintain the circuit's biochemical milieu. Nevertheless, whether the combined perfusion is superior to liver perfusion alone in protecting livers from donation after cardiac death (DCD) is unclear. We aimed to test the hypothesis and explored the mechanisms. Livers from 15 DCD pig donors were subjected to either static cold storage group (Group A), liver alone NMP group (Group B), or combined liver-kidney NMP group (Group C)...
October 10, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29023915/a-randomized-trial-of-obeticholic-acid-monotherapy-in-patients-with-primary-biliary-cholangitis
#5
Kris V Kowdley, Velimir Luketic, Roger Chapman, Gideon M Hirschfield, Raoul Poupon, Christoph Schramm, Catherine Vincent, Christian Rust, Albert Parés, Andrew Mason, David Shapiro, Luciano Adorini, Cathi Sciacca, Tessa Beecher-Jones, Olaf Böhm, Richard Pencek, David Jones
BACKGROUND: Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, was studied as monotherapy in an international, randomized, double-blind, placebo-controlled Phase 2 study in patients with primary biliary cholangitis (PBC) who were then reported for up to 6 years. The goals of the study were to assess the benefit of OCA in the absence of UDCA, which is relevant for patients who are intolerant of UDCA and at higher risk of disease progression. METHODS: Patients were randomized and dosed with placebo (n=23), OCA 10-mg (n=20), or OCA 50-mg (n=16) given as monotherapy once daily for 3 months (1 randomized patient withdrew prior to dosing)...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29018539/clinical-characteristics-of-antimitochondrial-antibody-positive-patients-at-a-safety-net-health-care-system-in-arizona
#6
Susanna Tan, Napatkamon Ayutyanont, Bikash Bhattarai, Zohreh Movahedi, Lakshmi Jayaram, Robert Gish, Abdul Nadir
BACKGROUND AND AIMS: To assess whether aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (AP) levels can predict the diagnosis of primary biliary cholangitis (PBC) or any other diagnoses and whether PBC occurs either simultaneously or independently of other liver diseases among antimitochondrial antibody (AMA)-positive patients. METHODS: Demographic and clinical variables were assessed in 90 AMA-positive patients with and without liver biopsies...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28989567/conjugated-hyperbilirubinemia-presenting-in-first-fourteen-days-in-term-neonates
#7
Fang Kuan Chiou, Christina Ong, Kong Boo Phua, Fares Chedid, Ajmal Kader
AIM: To describe the etiology and characteristics of early-onset conjugated hyperbilirubinemia (ECHB) presenting within 14 d of life in term neonates. METHODS: Retrospective review was performed of term infants up to 28-d-old who presented with conjugated hyperbilirubinemia (CHB) at a tertiary center over a 5-year period from January 2010 to December 2014. CHB is defined as conjugated bilirubin (CB) fraction greater than 15% of total bilirubin and CB greater or equal to 25 μmol/L...
September 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28987473/diagnosis-and-management-of-biliary-injuries
#8
J Bart Rose, William G Hawkins
No abstract text is available yet for this article.
August 2017: Current Problems in Surgery
https://www.readbyqxmd.com/read/28986171/early-indications-of-anit-induced-cholestatic-liver-injury-alteration-of-hepatocyte-polarization-and-bile-acid-homeostasis
#9
Tingting Yang, Huifang Mei, Dengqiu Xu, Wang Zhou, Xiaoyu Zhu, Lixin Sun, Xin Huang, Xue Wang, Ting Shu, Jia Liu, Jiaxin Ding, H M Hassan, Luyong Zhang, Zhenzhou Jiang
Hepatocyte polarization is essential for biliary secretion, and loss of polarity causes bile secretory failure and hepatotoxicity. Here, we showed that alpha-naphthyl isothiocyanate (ANIT)-induced liver injury was accompanied by the dynamic interruption of bile acid homeostasis in rat plasma, liver and bile, which was characterized by the redistribution of bile acids in plasma and bile and a small range of fluctuations in the liver. Molecular mechanism studies indicated that these factors are dynamically mediated by the disruption of bile acid transporters and hepatic tight junctions...
October 3, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28985867/laparoscopic-subtotal-cholecystectomy-compared-to-total-cholecystectomy-a-matched-national-analysis
#10
Young Kim, Koffi Wima, Andrew D Jung, Grace E Martin, Vikrom K Dhar, Shimul A Shah
BACKGROUND: Laparoscopic subtotal cholecystectomy (LSC) is considered a safe alternative to laparoscopic cholecystectomy (LC) if biliary anatomy is obscured by inflammation. While case series studies have observed low morbidity rates with LSC, the impact of operative conversion on patient outcomes is poorly understood. METHODS: A national analysis of all patients who underwent LC or LSC from 2009 to 2013 was performed using the University HealthSystem Consortium database...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28959005/machine-perfusion-at-20%C3%A2-c-prevents-ischemic-injury-and-reduces-hypoxia-inducible-factor-1%C3%AE-expression-during-rat-liver-preservation
#11
Clarissa Berardo, Laura Giuseppina Di Pasqua, Veronica Siciliano, Vittoria Rizzo, Plinio Richelmi, Andrea Ferrigno, Mariapia Vairetti
BACKGROUND Ischemic cholangitis is the main cause of liver failure after transplantation and subnormothermic machine perfusion may represent a better strategy than conventional cold storage, minimizing preservation injury. We compared livers preserved by machine perfusion at 20°C (MP20) or by cold storage at 4°C (CS4) with regard to hypoxia-inducible factor (HIF)-1α mRNA expression and protein stabilization in hypoxic conditions. MATERIAL AND METHODS Livers from male Wistar rats were stored on ice at 4°C in UW solution (CS4) or perfused with oxygenated Krebs-Henseleit buffer at 20°C (MP20) for six hours...
September 29, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28958806/role-of-tangeretin-as-a-potential-bioavailability-enhancer-for-silybin-pharmacokinetic-and-pharmacological-studies
#12
Zhong-Wen Yuan, Ya-Zhuo Li, Zhong-Qiu Liu, Sen-Ling Feng, Hua Zhou, Chang-Xiao Liu, Liang Liu, Ying Xie
Biological responses of a variety of naturally occurring compounds in vivo were restrained by their poor oral bioavailability. Silybin, as one of the active ingredients of silymarin, has presented promising bioactivity for the treatment of chronic liver diseases and cancer. However, its exposure in body was limited. In this study, silybin was demonstrated to be substrates of both BCRP and MRP2 by utilizing monolayer Caco-2 cell model and confirmed in MDCK cells overexpressing specific efflux transporter. Of all compounds screened, tangeretin, a potent inhibitor of efflux transporters of BCRP, MRP2 and P-gp, was able to enhance exposure of silybin by inhibiting functions of the barriers mediating transcellular transport...
September 25, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28954990/risk-factors-for-an-additional-port-in-single-incision-laparoscopic-cholecystectomy-in-patients-with-cholecystitis
#13
Kenichiro Araki, Ken Shirabe, Akira Watanabe, Norio Kubo, Shigeru Sasaki, Hideki Suzuki, Takayuki Asao, Hiroyuki Kuwano
Although single-incision laparoscopic cholecystectomy is now widely performed in patients with cholecystitis, some cases require an additional port to complete the procedure. In this study, we focused on risk factor of additional port in this surgery. We performed single-incision cholecystectomy in 75 patients with acute cholecystitis or after cholecystitis between 2010 and 2014 at Gunma University Hospital. Surgical indications followed the TG13 guidelines. Our standard procedure for single-incision cholecystectomy routinely uses two needlescopic devices...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28948425/endoscopic-therapy-of-biliary-injury-after-cholecystectomy
#14
Mia Rainio, Outi Lindström, Marianne Udd, Carola Haapamäki, Arno Nordin, Leena Kylänpää
BACKGROUND: Iatrogenic bile duct injury (BDI) is a common complication after cholecystectomy. Patients are mainly treated endoscopically, but the optimal treatment method has remained unclear. AIMS: The aim was to analyze endoscopic treatment in BDI after cholecystectomy and to explore endoscopic sphincterotomy (ES), with or without stenting, as the primary treatment for an Amsterdam type A bile leak. METHODS: All patients referred to Helsinki University Hospital endoscopy unit due to a suspected BDI between the years 2004 and 2014 were included in this retrospective study...
September 25, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28932348/liver-transplantation-in-the-treatment-of-severe-iatrogenic-liver-injuries
#15
REVIEW
Andrea Lauterio, Riccardo De Carlis, Stefano Di Sandro, Fabio Ferla, Vincenzo Buscemi, Luciano De Carlis
The place of liver transplantation in the treatment of severe iatrogenic liver injuries has not yet been widely discussed in the literature. Bile duct injuries during cholecystectomy represent the leading cause of liver transplantation in this setting, while other indications after abdominal surgery are less common. Urgent liver transplantation for the treatment of severe iatrogenic liver injury may-represent a surgical challenge requiring technically difficult and time consuming procedures. A debate is ongoing on the need for centralization of complex surgery in tertiary referral centers...
August 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28922301/hypothermic-liver-perfusion
#16
Andrea Schlegel, Xavier Muller, Philipp Dutkowski
PURPOSE OF REVIEW: The review describes recent developments in hypothermic machine liver perfusion with a special focus on underlying protective mechanisms, and the role of this perfusion technique in high-risk donor-recipient combinations. RECENT FINDINGS: To maximize the number of transplantable donor livers, several centres are exploring new machine preservation techniques. In this context, hypothermic machine perfusion has been recently introduced into the clinical setting of human liver transplantation, and the effect of endischemic cold liver perfusion on posttransplant complications is currently under investigation in two multicentre, randomized controlled trials...
September 15, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28921801/complications-symptoms-quality-of-life-and-pregnancy-in-cholestatic-liver-disease
#17
Kais Zakharia, Anilga Tabibian, Keith D Lindor, James H Tabibian
Cholestatic liver diseases (CLDs) encompass a variety of disorders of bile formation and/or flow which generally result in progressive hepatobiliary injury and ultimately end-stage liver disease. Many patients with CLD are diagnosed between the ages of 20-50 years, a particularly productive period of life professionally, biologically, and in other respects; it is not surprising, thus, that CLD is often associated with impaired health-related quality of life (HRQOL) and uncertainty regarding implications for and outcomes of pregnancy...
September 18, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28918963/laparoscopic-subtotal-cholecystectomy-a-surgical-alternative-to-reduce-complications-in-complex-cases
#18
Génesis Jara, José Rosciano, Wuendys Barrios, Liumariel Vegas, Omaira Rodríguez, Renata Sánchez, Alexis Sánchez
INTRODUCTION: Laparoscopic cholecystectomy is a common procedure in general surgery, and in complex cases it is important for the surgeon to know all the alternatives with low associated morbidity. Laparoscopic subtotal cholecystectomy should be considered as an option when a critical view of safety cannot be obtained, because it has a low complication rate and gives the advantages of minimally invasive surgery. METHODS: Retrospective study of laparoscopic subtotal cholecystectomies in an eight years period...
September 14, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28893353/the-cholangiocyte-adenosine-il6-axis-regulates-survival-during-biliary-cirrhosis
#19
Elise Lavoie, Michel Fausther, Jessica Goree, Jonathan Dranoff
BACKGROUND AND AIMSEpithelial response to injury is critical to the pathogenesis of biliary cirrhosis, and IL6 has been suggested as a mediator of this phenomenon. Several liver cell types can secrete IL6 following activation by various signaling molecules including circulating adenosine. The aims of this study are to assess whether adenosine can induce IL6 secretion by cholangiocytes via the A2b adenosine receptor (A2bAR) and determine the effect of A2bAR-sensitive IL6 release on injury response in biliary cirrhosis...
September 11, 2017: Gene Expression
https://www.readbyqxmd.com/read/28888832/ageing-sensitized-by-ipla2%C3%AE-deficiency-induces-liver-fibrosis-and-intestinal-atrophy-involving-suppression-of-homeostatic-genes-and-alteration-of-intestinal-lipids-and-bile-acids
#20
Li Jiao, Hongying Gan-Schreier, Xingya Zhu, Wang Wei, Sabine Tuma-Kellner, Gerhard Liebisch, Wolfgang Stremmel, Walee Chamulitrat
Ageing is a major risk factor for various forms of liver and gastrointestinal (GI) disease and genetic background may contribute to the pathogenesis of these diseases. Group VIA phospholipase A2 or iPLA2β is a homeostatic PLA2 by playing a role in phospholipid metabolism and remodeling. Global iPLA2β(-/-) mice exhibit aged-dependent phenotypes with body weight loss and abnormalities in the bone and brain. We have previously reported the abnormalities in these mutant mice showing susceptibility for chemical-induced liver injury and colitis...
September 6, 2017: Biochimica et Biophysica Acta
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