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One legacy

A N Gorban, I Y Tyukin
The concentrations of measure phenomena were discovered as the mathematical background to statistical mechanics at the end of the nineteenth/beginning of the twentieth century and have been explored in mathematics ever since. At the beginning of the twenty-first century, it became clear that the proper utilization of these phenomena in machine learning might transform the curse of dimensionality into the blessing of dimensionality This paper summarizes recently discovered phenomena of measure concentration which drastically simplify some machine learning problems in high dimension, and allow us to correct legacy artificial intelligence systems...
April 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Shanda H Blackmon, Andrea J Carpenter
The legacy of Nina Starr Braunwald lives on in the form of her innovations, clearing a path for women in cardiothoracic surgery, and the lives of those she has trained or supported. As one of the early pioneers in cardiac surgery, she represents what is excellent in our profession. The Braunwald family has donated to The Thoracic Surgery Foundation in the form of Research Awards, and a survey was conducted to determine the career paths of recipients since the first award in 1993.
March 16, 2018: Annals of Thoracic Surgery
Ayman Ebied, Ahmed Zayda, Sameh Marei, Hany Elsayed
INTRODUCTION: Successful treatment of knee comminuted periarticular fractures associated with osteoporosis and pre-existing arthritis is a challenging task. METHODS: This is a prospective study on 27 patients who had comminuted intra and periarticular knee fractures and pre-existing arthritis. Fractures were classified according to Muller's AO classification. Primary knee arthroplasty was performed ± internal fixation following 4 weeks of splinting. A stem was added to the tibial tray and Legacy Constrained Condylar Knee (LCCK) or Rotating Hinge (RH) prosthesis were used depending on the level of ligament damage and bone defects...
2018: SICOT-J
Manuel Delgado-Baquerizo, David J Eldridge, Fernando T Maestre, Senani B Karunaratne, Pankaj Trivedi, Peter B Reich, Brajesh K Singh
The technical comment from Sanderman provides a unique opportunity to deepen our understanding of the mechanisms explaining the role of paleoclimate in the contemporary distribution of global soil C content, as reported in our article. Sanderman argues that the role of paleoclimate in predicting soil C content might be accounted for by using slowly changing soil properties as predictors. This is a key point that we highlighted in the supplementary materials of our article, which demonstrated, to the degree possible given available data, that soil properties alone cannot account for the unique portion of the variation in soil C explained by paleoclimate...
March 2018: Science Advances
Richard Njouom, Isabelle Siffert, Gaëtan Texier, Guillaume Lachenal, Mathurin Cyrille Tejiokem, Jacques Pépin, Arnaud Fontanet
Cameroon is thought to have one of the highest prevalences of Hepatitis C virus (HCV) infection in the world (4·9% among adults). A marked cohort effect exists in several communities where ≈50% of the elderly are infected. Better assessment of HCV distribution is needed for planning treatment programs. We tested for HCV antibodies 14150 capillary blood samples collected during the 2011 Demographic and Health Survey, whose participants were representative of the Cameroonian population aged 15-49 (both genders) and 50-59 years (men only)...
March 13, 2018: Journal of Viral Hepatitis
Thomas C Jeffries, Smriti Rayu, Uffe N Nielsen, Kaitao Lai, Ali Ijaz, Loic Nazaries, Brajesh K Singh
Chemical contamination of natural and agricultural habitats is an increasing global problem and a major threat to sustainability and human health. Organophosphorus (OP) compounds are one major class of contaminant and can undergo microbial degradation, however, no studies have applied system-wide ecogenomic tools to investigate OP degradation or use metagenomics to understand the underlying mechanisms of biodegradation in situ and predict degradation potential. Thus, there is a lack of knowledge regarding the functional genes and genomic potential underpinning degradation and community responses to contamination...
2018: Frontiers in Microbiology
Fanny Guglielmucci, Isabella G Franzoi, Michela Bonafede, Francesca V Borgogno, Federica Grosso, Antonella Granieri
Aim: A cancer diagnosis-and in particular a Malignant Mesothelioma (MM) one-breaks the somatopsychic balance of the individual, compromising the quality of residual life and giving rise to many negative emotions difficult to integrate and to elaborate (such as depression, fears, anxieties, hopelessness, guilt, shame, and rage). Several national and international guidelines acknowledged the importance of evaluating psychological and socio-relational features in MM patients and their caregiver. However, only few studies have investigated the subjective experience of MM patients and even less research has focused on the caregivers' experience...
2018: Frontiers in Psychology
Francesca Rita Novara, Haymo Ross
The Prize is right! Chemistry-A European Journal will start an exciting journey exploring the significance of Nobel Prize awards in Chemistry in the corresponding contemporary chemistry fields. In this new journal feature called "The Nobel Legacy", a recurring series of invited Review-type articles each one connected to a particular Nobel Prize in Chemistry will be published.
March 6, 2018: Chemistry: a European Journal
Nicole Curato
One would be hard-pressed nowadays to find any practitioners and scholars in the field of post-disaster reconstruction who would argue against the virtues of community participation. In practice, however, the legacy of community participation has been mixed. This paper pursues this line of inquiry by examining the manifestations of participation in three communities affected by Typhoon Haiyan that struck the Philippines on 8 November 2013. The findings suggest that different governance logics emerge in each of the three case studies: authoritarian; communitarian; and deliberative...
February 27, 2018: Disasters
Emily L Mroz, Susan Bluck
People's preferences for memorializing loved ones vary and may depend on their personal attitudes and experiences with death. Participants (N = 145) completed the Memorializing Preferences Checklist and measures of personal attitudes and life experiences with death. Factor analysis identified four Memorializing Preferences. In terms of predicting preferences, greater acknowledgement of death, and having experienced more losses, predicted preference for memorializing through Societal Tradition, Community Legacy, and Continuing Intimacy...
February 23, 2018: Death Studies
Thomas Schneider, Geoffrey H Smith, Michael R Rossi, Charles E Hill, Linsheng Zhang
Bioinformatic analysis is an integral and critical part of clinical next-generation sequencing. It is especially challenging for some pipelines to consistently identify insertions and deletions. We present the validation of an open source tumor amplicon pipeline (OTA-pipeline) for clinical next-generation sequencing targeting solid tumor-associated variants. Raw data generated from 557 TruSight Tumor 26 samples as well as in silico data were analyzed by the OTA-pipeline and legacy pipeline and compared. Discrepant results were confirmed by orthogonal methods...
February 19, 2018: Journal of Molecular Diagnostics: JMD
Hannes Schroeder, Martin Sikora, Shyam Gopalakrishnan, Lara M Cassidy, Pierpaolo Maisano Delser, Marcela Sandoval Velasco, Joshua G Schraiber, Simon Rasmussen, Julian R Homburger, María C Ávila-Arcos, Morten E Allentoft, J Víctor Moreno-Mayar, Gabriel Renaud, Alberto Gómez-Carballa, Jason E Laffoon, Rachel J A Hopkins, Thomas F G Higham, Robert S Carr, William C Schaffer, Jane S Day, Menno Hoogland, Antonio Salas, Carlos D Bustamante, Rasmus Nielsen, Daniel G Bradley, Corinne L Hofman, Eske Willerslev
The Caribbean was one of the last parts of the Americas to be settled by humans, but how and when the islands were first occupied remains a matter of debate. Ancient DNA can help answering these questions, but the work has been hampered by poor DNA preservation. We report the genome sequence of a 1,000-year-old Lucayan Taino individual recovered from the site of Preacher's Cave in the Bahamas. We sequenced her genome to 12.4-fold coverage and show that she is genetically most closely related to present-day Arawakan speakers from northern South America, suggesting that the ancestors of the Lucayans originated there...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
Sören Verstraete, Ilse Vanhorebeek, Esther van Puffelen, Inge Derese, Catherine Ingels, Sascha C Verbruggen, Pieter J Wouters, Koen F Joosten, Jan Hanot, Gonzalo G Guerra, Dirk Vlasselaers, Jue Lin, Greet Van den Berghe
BACKGROUND: Children who have suffered from critical illnesses that required treatment in a paediatric intensive care unit (PICU) have long-term physical and neurodevelopmental impairments. The mechanisms underlying this legacy remain largely unknown. In patients suffering from chronic diseases hallmarked by inflammation and oxidative stress, poor long-term outcome has been associated with shorter telomeres. Shortened telomeres have also been reported to result from excessive food consumption and/or unhealthy nutrition...
February 21, 2018: Critical Care: the Official Journal of the Critical Care Forum
Richard W Smith, Richard D Moccia, Carmel E Mothersill, Colin B Seymour
This study extends the investigation of the legacy effects of exposure to a single radiation dose at one of four early life stages, in adult rainbow trout (Part A), by examining the effects of a second identical dose after one year; i.e. egg 48 h after fertilisation (48 h egg) + 1 year, eyed egg + 1 year, yolk sac larvae (YSL) + 1 year and first feeder + 1 year. This included the induction of a bystander effect in non-irradiated trout which had swam with the irradiated fish. The second radiation dose negated any beneficial proteomic responses following early life stage irradiation only, particularly irradiation of 48 h eggs and eyed eggs (Part A)...
February 9, 2018: Environmental Research
Xiaojia Zhu, Yuyan Guan, Anthony V Signore, Chandrasekhar Natarajan, Shane G DuBay, Yalin Cheng, Naijian Han, Gang Song, Yanhua Qu, Hideaki Moriyama, Federico G Hoffmann, Angela Fago, Fumin Lei, Jay F Storz
When different species experience similar selection pressures, the probability of evolving similar adaptive solutions may be influenced by legacies of evolutionary history, such as lineage-specific changes in genetic background. Here we test for adaptive convergence in hemoglobin (Hb) function among high-altitude passerine birds that are native to the Qinghai-Tibet Plateau, and we examine whether convergent increases in Hb-O2 affinity have a similar molecular basis in different species. We documented that high-altitude parid and aegithalid species from the Qinghai-Tibet Plateau have evolved derived increases in Hb-O2 affinity in comparison with their closest lowland relatives in East Asia...
February 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
Krysta S Barton, Tyler Tate, Nancy Lau, Karen B Taliesin, Elisha D Waldman, Abby R Rosenberg
CONTEXT: Supporting patients' spiritual needs is central to palliative care. Adolescents and Young Adults (AYAs) may be developing their spiritual identities; it is unclear how to navigate conversations concerning their spiritual needs. OBJECTIVES: To (1) describe spiritual narratives among AYAs based on their self-identification as religious, spiritual, both, or neither; and, (2) identify language to support AYA spiritual needs in keeping with their self-identities...
February 8, 2018: Journal of Pain and Symptom Management
Florian Reverey, Lars Ganzert, Gunnar Lischeid, Andreas Ulrich, Katrin Premke, Hans-Peter Grossart
Understanding interrelations between an environment's hydrological past and its current biogeochemistry is necessary for the assessment of biogeochemical and microbial responses to changing hydrological conditions. The question how previous dry-wet events determine the contemporary microbial and biogeochemical state is addressed in this study. Therefore, sediments exposed to the atmosphere of areas with a different hydrological past within one kettle hole, i.e. (1) the predominantly inundated pond center, (2) the pond margin frequently desiccated for longer periods and (3) an intermediate zone, were incubated with the same rewetting treatment...
February 2, 2018: Science of the Total Environment
Elizabeth M Reagan, Robert T Nguyen, Shreyas T Ravishankar, Vikram Chabra, Barbara Fuentes, Rebecca Spiegel, Sam Parnia
OBJECTIVES: To date, no studies have examined real-time electroencephalography and cerebral oximetry monitoring during cardiopulmonary resuscitation as markers of the magnitude of global ischemia. We therefore sought to assess the feasibility of combining cerebral oximetry and electroencephalography in patients undergoing cardiopulmonary resuscitation and further to evaluate the electroencephalography patterns during cardiopulmonary resuscitation and their relationship with cerebral oxygenation as measured by cerebral oximetry...
February 6, 2018: Critical Care Medicine
Domancar Orona-Tamayo, María Elena Valverde, Octavio Paredes López
This review reported an updated survey on the molecular functional properties of bioactive peptides derived from different Latin American ancient grains such as Maize, common Bean, Amaranth, Quinoa and Chia seeds. Seed storage proteins encrypted in their sequences diverse peptides associated with a wide range of benefit effects on the human health and the most studied are antihypertensive, anti-cholesterolemic, antioxidant, anti-inflammatory, anticancer, antimicrobial and immunomodulatory properties, additionally, in the last decades molecular properties have been also used for their characterization to understand their activities and it makes it highly attractive to be incorporated into food formulations and to complement or replace some conventional cereal grains...
February 1, 2018: Critical Reviews in Food Science and Nutrition
George M Bohigian, Robert M Feibel
The Francis I. Proctor Foundation for Research in Ophthalmology is internationally recognized for its research in the fields of ocular inflammatory and infectious diseases. Although the name of one of its founders, Francis I. Proctor, MD (1864-1936) is memorialized, the legacy of his wife, Elizabeth C. Proctor (1882-1975) is not as well known. They were both full partners in this endeavor. Francis, a successful and wealthy ophthalmologist, retired to Santa Fe, New Mexico. After their marriage, they became interested in the problem of blinding trachoma, then an endemic problem on the Native American Indian reservations...
January 1, 2018: Journal of Medical Biography
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