keyword
MENU ▼
Read by QxMD icon Read
search

Niacin

keyword
https://www.readbyqxmd.com/read/29137352/maternal-high-calorie-diet-induces-mitochondrial-dysfunction-and-senescence-phenotype-in-subcutaneous-fat-of-newborn-mice
#1
Daniele Lettieri-Barbato, Fabiana D'Angelo, Francesca Sciarretta, Giuseppe Tatulli, Flavia Tortolici, Maria Rosa Ciriolo, Katia Aquilano
Mitochondrial dysfunction, inflammation and senescence-like features are observed in adipose depots in aging and obesity. Herein, we evaluated how maternal high calorie diet (HCD) may impact on subcutaneous adipose tissue (sAT) of the newborn mice. Adult C57BL/6J mice were randomly divided in three groups: normal calorie diet (NCD), HCD and HCD supplemented with niacin 8 weeks before mating. Mothers and pups were then sacrificed and metabolic and molecular analyses were carried out on sAT. HCD induced mitochondria dysfunction in mothers without inflammation and senescence, whereas in pups we also revealed the occurrence of senescent phenotype...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133979/dietary-nutrients-associated-with-preservation-of-lung-function-in-hispanic-and-non-hispanic-white-smokers-from-new-mexico
#2
Shuguang Leng, Maria A Picchi, Yohannes Tesfaigzi, Guodong Wu, W James Gauderman, Fadi Xu, Frank D Gilliland, Steven A Belinsky
Background: COPD is the third leading cause of death in the United States. Cigarette smoking accelerates the age-related forced expiratory volume in 1 s (FEV1) decline, an important determinant for the genesis of COPD. Hispanic smokers have lower COPD prevalence and FEV1 decline than non-Hispanic whites (NHWs). Patients and methods: A nutritional epidemiological study was conducted in the Lovelace Smokers cohort (LSC; n=1,829) and the Veterans Smokers cohort (n=508) to identify dietary nutrients (n=139) associated with average FEV1 and its decline and to assess whether nutrient intakes could explain ethnic disparity in FEV1 decline between Hispanics and NHW smokers...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29118161/dietary-nutrient-intake-ethnicity-and-epigenetic-silencing-of-lung-cancer-genes-detected-in-sputum-in-new-mexican-smokers
#3
Shuguang Leng, Maria A Picchi, Huining Kang, Guodong Wu, Piotr T Filipczak, Daniel E Juri, Xiequn Zhang, W James Gauderman, Frank D Gilliland, Steven A Belinsky
Lung cancer (LC) gene methylation detected in sputum assesses field cancerization and predicts LC incidence. Hispanic smokers have higher LC susceptibility compared to non-Hispanic Whites (NHW). We aimed to identify novel dietary nutrients affecting LC gene methylation and determine the degree of ethnic disparity in methylation explained by diet. Dietary intakes of 139 nutrients were assessed using a validated Harvard food frequency questionnaire in 327 Hispanics and 1502 NHWs from the Lovelace Smokers cohort (LSC)...
November 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29113038/micronutrient-dietary-intake-in-latina-pregnant-adolescents-and-its-association-with-level-of-depression-stress-and-social-support
#4
Angelie Singh, Caroline Trumpff, Jeanine Genkinger, Alida Davis, Marisa Spann, Elizabeth Werner, Catherine Monk
Adolescent pregnant women are at greater risk for nutritional deficits, stress, and depression than their adult counterparts, and these risk factors for adverse pregnancy outcomes are likely interrelated. This study evaluated the prevalence of nutritional deficits in pregnant teenagers and assessed the associations among micronutrient dietary intake, stress, and depression. One hundred and eight pregnant Latina adolescents completed an Automated Self-Administered 24-hour dietary recall (ASA24) in the 2nd trimester...
November 4, 2017: Nutrients
https://www.readbyqxmd.com/read/29109962/micronutrient-intake-in-a-cohort-of-italian-adults-with-type-1-diabetes-adherence-to-dietary-recommendations
#5
Marisa Giorgini, Marilena Vitale, Lutgarda Bozzetto, Ornella Ciano, Angela Giacco, Anna Rivieccio, Ilaria Calabrese, Gabriele Riccardi, Angela A Rivellese, Giovanni Annuzzi
Micronutrients are of fundamental importance in maintaining health status. However, data on their dietary intake are few particularly in persons with diabetes. The aim of this study was to evaluate in adults with type 1 diabetes (T1DM) attending a tertiary-level diabetes center in Southern Italy the intake of micronutrients (both vitamins and minerals) and the adherence to recommendations. Seven-day food records of 60 T1DM patients were analyzed. Micronutrient intake was evaluated based on the Italian food composition tables and expressed as amount per 1000 kcal of energy intake to adjust for possible underreporting...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29108128/safety-assessment-of-niacin-in-the-us-food-and-drug-administration-s-mini-sentinel-system
#6
Joshua J Gagne, Monika Houstoun, Marsha E Reichman, Christian Hampp, James H Marshall, Sengwee Toh
PURPOSE: The Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2-THRIVE) trial found higher incidence rates of adverse reactions, including bleeding, in patients receiving the combination of extended-release niacin and laropiprant versus placebo. It is not known whether these adverse events are attributable to laropiprant, not approved in the USA, or to extended-release niacin. We compared rates of major gastrointestinal bleeding and intracranial hemorrhage among initiators of extended-release niacin and initiators of fenofibrate...
November 6, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29102145/modulating-adipose-tissue-lipolysis-and-remodeling-to-improve-immune-function-during-the-transition-period-and-early-lactation-of-dairy-cows
#7
G Andres Contreras, Clarissa Strieder-Barboza, Jenne De Koster
Despite major advances in our understanding of transition and early lactation cow physiology and the use of advanced dietary, medical, and management tools, at least half of early lactation cows are reported to develop disease and over half of cow deaths occur during the first week of lactation. Excessive lipolysis, usually measured as plasma concentrations of free fatty acids (FFA), is a major risk factor for the development of displaced abomasum, ketosis, fatty liver, and metritis, and may also lead to poor lactation performance...
October 25, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29100430/novel-naprt-specific-antibody-identifies-small-cell-lung-cancer-and-neuronal-cancers-as-promising-clinical-indications-for-a-nampt-inhibitor-niacin-co-administration-strategy
#8
Jonathan Cole, Marie-Christine Guiot, Michel Gravel, Cynthia Bernier, Gordon C Shore, Anne Roulston
Tumor cells are particularly dependent on NAD(+) due to higher rates of metabolism, DNA synthesis and repair. Nicotinamide phosphoribosyltransferase inhibitors (NAMPTis) inhibit NAD(+) biosynthesis and represent promising new anti-cancer agents. However, clinical efficacy has been limited by toxicities demonstrating the need for drug combinations to broaden the therapeutic index. One potential combination involves niacin/NAMPTi co-administration. Niacin can rescue NAD(+) biosynthesis through a parallel pathway that depends on nicotinic acid phosphoribosyltransferase (NAPRT) expression...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29096859/lipoprotein-a-apheresis-in-the-light-of-new-drug-developments
#9
Anja Vogt
Elevated levels of lipoprotein(a) (Lp(a)) contribute to the risk of early and severe cardiovascular disease (CVD). Recently <50 mg/dl was recommended as the desirable level for clinical use and decision making. All established medical therapies to lower cholesterol levels have no impact on lowering Lp(a) except niacin which is all too often poorly tolerated and not obtainable everywhere. Lipoprotein apheresis is an extracorporeal treatment to lower levels of Lp(a) significantly by > 60%. In some countries it is recommended in very high risk patients with early or progressive CVD...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29094796/severely-inadequate-micronutrient-intake-among-children-9-24%C3%A2-months-in-nepal-the-mal-ed-birth-cohort-study
#10
Marianne S Morseth, Liv Elin Torheim, Ram K Chandyo, Manjeswori Ulak, Sanjaya K Shrestha, Binob Shrestha, Are Hugo Pripp, Sigrun Henjum
Prevalence of micronutrient deficiencies is high among infants and children in low- and middle income countries, but knowledge about nutrient adequacy across the complementary feeding period is limited. We investigated probability of adequacy (PA) of breast milk and complementary food combined and nutrient density adequacy (NDA) of complementary food and tracking of NDA over time among 229 children from 9-24 months of age in Bhaktapur, Nepal. Monthly, 24 h dietary recalls (16 in total) were performed and subgrouped into four 4-month time periods...
November 2, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29077970/identification-of-the-niacin-blunted-subgroup-of-schizophrenia-patients-from-mood-disorders-and-healthy-individuals-in-chinese-population
#11
Liya Sun, Xuhan Yang, Jie Jiang, Xiaowen Hu, Ying Qing, Dandan Wang, Tianqi Yang, Chao Yang, Juan Zhang, Ping Yang, Peng Wang, Changqun Cai, Jijun Wang, Lin He, Chunling Wan
Schizophrenia (SZ) is a devastating mental disease caused by complex genetic and environmental factors. The pathological process and clinical manifestation of SZ are heterogeneous among patients, which hampers precise diagnosis and treatment of the disease. Since no objective marker for SZ has been established today, to identify a subgroup of the patients with homogeneous biochemical traits will provide a new angle for both researchers and clinicians to understand and manage the disease. In this study, we employed the niacin skin-flushing test in Chinese population and confirmed a niacin-blunted subgroup of SZ patients distinguishable from mood disorders (MD) and normal individuals...
October 25, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29072717/stable-isotope-labeling-by-essential-nutrients-in-cell-culture-silec-for-accurate-measurement-of-nicotinamide-adenine-dinucleotide-metabolism
#12
David W Frederick, Sophie Trefely, Alexia Buas, Jason Goodspeed, Jay Singh, Clementina Mesaros, Joseph A Baur, Nathaniel W Snyder
Nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) are conserved metabolic cofactors that mediate reduction-oxidation (redox) reactions throughout all domains of life. The diversity of synthetic routes and cellular processes involving the transfer of reducing equivalents to and from these cofactors makes the accurate quantitation and metabolic tracing of NAD(H) and NADP(H) of broad interest. However, current analytical techniques typically rely on standard curves that do not incorporate confounding effects of the sample matrix...
October 26, 2017: Analyst
https://www.readbyqxmd.com/read/29071784/simultaneous-determination-of-niacin-and-pyridoxine-at-trace-levels-by-using-diode-array-high-performance-liquid-chromatography-and-liquid-chromatography-with-quadrupole-time-of-flight-tandem-mass-spectrometry
#13
Sabriye Sel, Elif Öztürk Er, Sezgin Bakırdere
A highly sensitive and simple diode-array high-performance liquid chromatography and liquid chromatography with quadrupole time-of-flight tandem mass spectrometry method was developed for the simultaneous determination of niacin and pyridoxine in pharmaceutical drugs, tap water and wastewater samples. To determine the in vivo behavior of niacin and pyridoxine, analytes were subjected to simulated gastric conditions. The calibration plots of the diode-array high-performance liquid chromatography and liquid chromatography with quadrupole time-of-flight tandem mass spectrometry method showed good linearity over a wide concentration range with close to 1...
October 26, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29070711/dietary-b-vitamin-intake-is-associated-with-lower-urinary-monomethyl-arsenic-and-oxidative-stress-marker-15-f2t-isoprostane-among-new-hampshire-adults
#14
Caitlin G Howe, Zhigang Li, Michael S Zens, Thomas Palys, Yu Chen, Jacqueline Y Channon, Margaret R Karagas, Shohreh F Farzan
Background: Arsenic exposure has been associated with an increased risk of cardiovascular disease (CVD). Growing evidence suggests that B vitamins facilitate arsenic metabolism and may protect against arsenic toxicity. However, to our knowledge, few studies have evaluated this in US populations.Objective: Our objective was to examine whether higher B vitamin intake is associated with enhanced arsenic metabolism and lower concentrations of preclinical markers of CVD among New Hampshire adults.Methods: We used weighted quantile sum (WQS) regression to evaluate the collective impact of 6 dietary B vitamins (thiamin, riboflavin, folate, niacin, and vitamins B-6 and B-12) on 1) the proportion of arsenic metabolites in urine and 2) 6 CVD-related markers [including urinary 15-F2t-isoprostane (15-F2t-IsoP)] among 418 participants (26-75 y of age) from the New Hampshire Health Study...
October 25, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/29066482/the-effect-of-metformin-on-the-expression-of-gpr109a-nf-%C3%AE%C2%BAb-and-il-1%C3%AE-in-peripheral-blood-leukocytes-from-patients-with-type-2-diabetes-mellitus
#15
Xiaoling Xu, Shaoda Lin, Yongsong Chen, Xitao Li, Shuhua Ma, Yucai Fu, Chiju Wei, Chang Wang, Wencan Xu
OBJECTIVES: Type 2 Diabetes Mellitus (T2DM), which often accompanies dyslipidemia, is considered an inflammatory disease. GPR109A, as a niacin receptor, is up-regulated under high glucose concentration. Activation of GPR109A reduces GSIS and exerts anti-inflammatory effects by regulating NF-κB/IL-1β signaling. Metformin improves hyperglycemia, increases insulin sensitivity and attenuates the activation of the NF-κB pathway in T2DM. We aimed to examine whether metformin plays beneficial effects in T2DM by regulating the GPR109A signaling...
September 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29037390/effect-of-feeding-rumen-protected-capsule-containing-niacin-k2so4-vitamin-c-and-gamma-aminobutyric-acid-on-heat-stress-and-performance-of-dairy-cows
#16
W J Guo, L Zhen, J X Zhang, S Lian, H F Si, J R Guo, H M Yang
This study was conducted to evaluate the effects of supplemental rumen-protected capsule (RPC) on animal performance, serological indicators, and serum heat shock protein 70 (HSP70) of lactating Holstein cows under heat stress (HS). During summer months, 30 healthy multiparous lactating Holstein cows with a parity number of 3.1 ± 0.44, 70 ± 15 d in milk, an average body weight of 622 ± 62kg, and an average milk yield of 32.28 ± 0.96kg/d, were used. The cows were randomly allocated to two groups: a control group and an RPC-supplemented group (0...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29037329/smokers-report-lower-intake-of-key-nutrients-than-nonsmokers-yet-both-fall-short-of-meeting-recommended-intakes
#17
Susan K Raatz, Lisa Jahns, LuAnn K Johnson, Angela Scheett, Alicia Carriquiry, Andrine Lemieux, Motohiro Nakajima, Mustafa al'Absi
Smoking is a major risk factor in the development of preventable disease which may be due to a poorer diet and the reduced nutrient intake of smokers. Our objective was to compare and evaluate the reported intake of current smokers with that of nonsmokers among participants of a study evaluating stress and smoking. We hypothesized (1) that overall energy and nutrient intake would be reduced in smokers compared with nonsmokers and (2) that smokers would have increased noncompliance with Dietary Reference Intakes (DRIs)...
September 2017: Nutrition Research
https://www.readbyqxmd.com/read/29037327/low-dietary-intake-of-n-3-fatty-acids-niacin-folate-and-vitamin-c-in-korean-patients-with-schizophrenia-and-the-development-of-dietary-guidelines-for-schizophrenia
#18
Eun Jin Kim, So Young Lim, Hee Jae Lee, Ju-Yeon Lee, Seunggi Choi, Seon-Young Kim, Jae-Min Kim, Il-Seon Shin, Jin-Sang Yoon, Soo Jin Yang, Sung-Wan Kim
Inappropriate dietary intake and poor nutritional status are reported to be associated with metabolic syndrome and psychopathology in patients with schizophrenia. We hypothesized that inappropriate dietary habits and insufficient dietary intake of specific nutrients are associated with schizophrenia. To test the hypothesis, we assessed the dietary habits and nutritional intake of patients with schizophrenia and then developed suitable dietary guidelines. In total, 140 subjects (73 controls and 67 patients with schizophrenia from community mental health centers) were included, and dietary intakes were analyzed using a semi-quantitative food frequency questionnaire...
September 2017: Nutrition Research
https://www.readbyqxmd.com/read/29036893/development-and-validation-of-a-food-frequency-questionnaire-to-estimate-intake-among-children-and-adolescents-in-urban-peru
#19
Carly A Rodriguez, Emily R Smith, Eduardo Villamor, Nelly Zavaleta, Graciela Respicio-Torres, Carmen Contreras, Sara Perea, Judith Jimenez, Karen Tintaya, Leonid Lecca, Megan B Murray, Molly F Franke
Tools to assess intake among children in Latin America are limited. We developed and assessed the reproducibility and validity of a semi-quantitative food frequency questionnaire (FFQ) administered to children, adolescents, and their caregivers in Lima, Peru. We conducted 24-h diet recalls (DRs) and focus groups to develop a locally-tailored FFQ prototype for children aged 0-14 years. To validate the FFQ, we administered two FFQs and three DRs to children and/or their caregivers (N = 120) over six months. We examined FFQ reproducibility by quartile agreement and Pearson correlation coefficients, and validity by quartile agreement and correlation with DRs...
October 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29019348/paediatric-endocrinology-can-niacin-supplementation-protect-against-congenital-malformations
#20
Melanie Penke, Wieland Kiess
No abstract text is available yet for this article.
October 11, 2017: Nature Reviews. Endocrinology
keyword
keyword
7722
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"