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Niacin

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https://www.readbyqxmd.com/read/28933636/nicotinic-acid-inhibits-angiogenesis-likely-through-cytoskeleton-remodeling
#1
Lemen Pan, Guanfeng Yu, Xiangjian Chen, Xiaoqiang Li
Angiogenesis is a physiological procedure during which the new blood vessels develop from the pre-existing vessels. Uncontrolled angiogenesis is related to various diseases including cancers. Clinical inhibition of undesired angiogenesis is still under investigation. We utilized nicotinic acid, a family member of the B-vitamin niacin (vitamin B3) that has been used in the prevention and treatment of atherosclerosis or other lipid-metabolic disorders, to treat human umbilical vein endothelial cells (HUVECs) and chick chorioallantoic membrane (CAM), and investigated its influence on angiogenesis in vitro and in vivo...
September 21, 2017: Organogenesis
https://www.readbyqxmd.com/read/28927896/niacin-and-heart-disease-prevention-engraving-its-tombstone-is-a-mistake
#2
REVIEW
Harold Robert Superko, Xue-Qiao Zhao, Howard N Hodis, John R Guyton
Niacin (nicotinic acid) has been used for primary and secondary coronary heart disease prevention for over 40 years. Until recently clinical trials incorporating niacin as part of an intervention strategy consistently demonstrated reduction in clinical events and lesion improvement, including ≥6% absolute mortality reduction. Two large clinical event trials in 2011 (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes) and 2014 (Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events) concluded that niacin added to statin therapy did not provide clinical event benefit over statin alone...
August 24, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28921450/nutrients-other-than-selenium-are-important-for-promoting-children-s-health-in-kashin-beck-disease-areas
#3
Yujie Ning, Xi Wang, Xiong Guo, Pan Zhang, Pengfei Qu, Feng Zhang, Sen Wang, Yanxia Lei, Mikko Lammi
Overall nutritional status has been proved associated with people's health. The overall nutritional status of children in Kashin-Beck disease (KBD) areas has been overlooked for decades. Therefore, it is worth investigating in the current generation to gather evidence and make suggestions for improvement. A cross-sectional study with three 24-h dietary recalls was conducted to collect raw data on the daily food intake of children. Recorded food was converted into daily nutrient intakes using CDGSS 3.0 software...
September 18, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28855229/niacin-nad-and-malformations
#4
Robert Scott-Jupp
No abstract text is available yet for this article.
August 30, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28845528/nutrient-intake-and-urinary-incontinence-in-korean-women-a-propensity-score-matched-analysis-from-the-korea-national-health-and-nutrition-examination-survey-data
#5
Jun Ho Lee, Hyo Serk Lee
OBJECTIVES: To evaluate the relationship between dietary nutrients and female urinary incontinence using nationally representative data from Korea. METHODS: We included 8090 women aged >20 years who had participated in the Korea National Health and Nutrition Examination Survey IV. We carried out a propensity-matched study by identifying women with urinary incontinence. Women without urinary incontinence, matched for age, body mass index, menopause, delivery history, hypertension, diabetes, hypercholesterolemia, stroke, asthma, chronic obstructive pulmonary disease and amount of total food intake, were included as a control group at a 2:1 ratio (661 women with urinary incontinence; 1322 women without urinary incontinence)...
August 28, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28842638/efficacy-of-laropiprant-in-minimizing-brain-injury-following-experimental-intracerebral-hemorrhage
#6
Abdullah Shafique Ahmad, Monique Mendes, Damian Hernandez, Sylvain Doré
Intracerebral hemorrhage (ICH) is one of the most devastating and disabling forms of stroke, yet effective treatments are still lacking. Prostaglandins and their receptors have been implicated in playing vital roles in ICH outcomes. Recently, laropiprant, a DP1 receptor antagonist, has been used in combination with niacin to abolish the prostaglandin D2-(PGD2)-induced flushing. Here, we test the hypothesis that laropiprant limits bleeding and rescues the brain from ICH. Wildtype (WT) and DP1(-/-) mice were subjected ICH and neurologic deficits and hemorrhagic lesion outcomes were evaluated at 72 hours after the ICH...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28839213/metabolomic-compounds-identified-in-piriformospora-indica-colonized-chinese-cabbage-roots-delineate-symbiotic-functions-of-the-interaction
#7
Mo Da-Sang Hua, Rajendran Senthil Kumar, Lie-Fen Shyur, Yuan-Bin Cheng, Zhihong Tian, Ralf Oelmüller, Kai-Wun Yeh
Root colonization by endophytic fungus Piriformospora indica facilitating growth/development and stress tolerance has been demonstrated in various host plants. However, global metabolomic studies are rare. By using high-throughput gas-chromatography-based mass spectrometry, 549 metabolites of 1,126 total compounds observed were identified in colonized and uncolonized Chinese cabbage roots, and hyphae of P. indica. The analyses demonstrate that the host metabolomic compounds and metabolite pathways are globally reprogrammed after symbiosis with P...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807460/metabolic-syndrome-cluster-does-not-provide-incremental-prognostic-information-in-patients-with-stable-cardiovascular-disease-a-post-hoc-analysis-of-the-aim-high-trial
#8
Radmila Lyubarova, Jennifer G Robinson, Michael Miller, Debra L Simmons, Ping Xu, Beth L Abramson, Marshall B Elam, Todd M Brown, Ruth McBride, Jerome L Fleg, Patrice Desvigne-Nickens, Woubeshet Ayenew, William E Boden
BACKGROUND: Metabolic syndrome (MS) is a well-known risk factor for the development of cardiovascular (CV) disease; yet, controversy persists whether it adds incremental prognostic value in patients with established CV disease. OBJECTIVES: This study was performed to determine if MS is associated with worse CV outcomes in patients with established CV disease treated intensively with statins. METHODS: We performed a post hoc analysis of the Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes trial, in which patients with established CV disease and atherogenic dyslipidemia (n = 3414) were randomly assigned to receive extended release niacin or placebo during a mean 36-month follow-up, to assess whether the presence of MS or the number of MS components contributed to CV outcomes...
July 5, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28806113/-hungarian-diet-and-nutritional-status-survey-the-otap2014-study-v-vitamin-intake-of-the-hungarian-population
#9
Erzsébet Schreiberné Molnár, Zsuzsanna Nagy-Lőrincz, Barbara Nagy, Márta Bakacs, Orsolya Kis, Eszter Sarkadi Nagy, Éva Martos
INTRODUCTION AND AIM: The Hungarian Diet and Nutritional Status Survey was implemented on a sub-sample of the European Health Interview Survey. In this paper, the authors present the data on the vitamin intake of the Hungarian population. METHOD: The survey represents the vitamin intake of the Hungarian non-institutionalised adult population of 18 years and older. There are significant differences between men's and women's vitamin intake. RESULTS: The intake of all water-soluble vitamins except for vitamin C is higher in men than in women, and the difference between the genders regarding the intake of vitamin E and D is significant...
August 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28803010/short-communication-apparent-ruminal-synthesis-of-b-vitamins-in-lactating-dairy-cows-fed-saccharomyces-cerevisiae-fermentation-product
#10
D S Castagnino, Y Ying, M S Allen, R Gervais, P Y Chouinard, C L Girard
Apparent ruminal synthesis and duodenal flow of thiamin, riboflavin, niacin, vitamin B6, folates, and vitamin B12 were evaluated in an experiment using 15 ruminally and duodenally cannulated lactating Holstein cows fed a basal diet, according to a crossover design, supplemented or not with 56 g/d of Saccharomyces cerevisiae fermentation product. Duration of the treatment period was 28 d. The basal ration had 28% neutral detergent fber, 30% starch and 16.5% crude protein; forages were corn silage (67% of forage dry matter) and alfalfa silage (33% of forage dry matter)...
August 9, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28792876/nad-deficiency-congenital-malformations-and-niacin-supplementation
#11
Hongjun Shi, Annabelle Enriquez, Melissa Rapadas, Ella M M A Martin, Roni Wang, Julie Moreau, Chai K Lim, Justin O Szot, Eddie Ip, James N Hughes, Kotaro Sugimoto, David T Humphreys, Aideen M McInerney-Leo, Paul J Leo, Ghassan J Maghzal, Jake Halliday, Janine Smith, Alison Colley, Paul R Mark, Felicity Collins, David O Sillence, David S Winlaw, Joshua W K Ho, Gilles J Guillemin, Matthew A Brown, Kazu Kikuchi, Paul Q Thomas, Roland Stocker, Eleni Giannoulatou, Gavin Chapman, Emma L Duncan, Duncan B Sparrow, Sally L Dunwoodie
BACKGROUND: Congenital malformations can be manifested as combinations of phenotypes that co-occur more often than expected by chance. In many such cases, it has proved difficult to identify a genetic cause. We sought the genetic cause of cardiac, vertebral, and renal defects, among others, in unrelated patients. METHODS: We used genomic sequencing to identify potentially pathogenic gene variants in families in which a person had multiple congenital malformations...
August 10, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28781803/cystoid-macular-edema-secondary-to-paclitaxel-therapy-for-ovarian-cancer-a-case-report
#12
Emma Bassi, Vera Loizzi, Claudio Furino, Rosa Martino, Giovanni Alessio, Cicinelli Ettore, Gennaro Cormio
Paclitaxel is a member of the taxane agents that has demonstrated efficacy in ovarian cancer, both in first- and in second-line therapy. Counted among the side-effects of this drug are neurological disorders. In the present study, a rare case of a non-neuropathic ocular disorder, known as cystoid macular edema (CME), due to paclitaxel in patients treated for ovarian cancer is described. Macular edema, or CME, is a common cause of visual impairment that has been classically demonstrated by fluorescein angiograms, showing capillary leakage...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28780095/short-communication-effect-of-fatty-acid-supplements-on-apparent-ruminal-synthesis-of-b-vitamins-in-lactating-dairy-cows
#13
D S Castagnino, K J Harvatine, M S Allen, R Gervais, P Y Chouinard, C L Girard
The effect of fat supplements (FS) providing different proportions of saturated (SFA) and unsaturated (UFA) fatty acids on supply, apparent ruminal synthesis (ARS), and duodenal flow (DF) of some B vitamins (thiamine, riboflavin, niacin, vitamin B6, folates, and vitamin B12) were evaluated in an experiment using 8 ruminally and duodenally cannulated lactating Holstein cows. The experiment was a replicated 4 × 4 Latin square design with 21-d treatment periods. The 4 treatments were a control diet without fatty acid supplement and 3 diets with 2...
August 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28769047/effect-of-niacin-on-inflammation-and-angiogenesis-in-a-murine-model-of-ulcerative-colitis
#14
Hesham Aly Salem, Walaa Wadie
Butyrate and niacin are produced by gut microbiota, however butyrate has received most attention for its effects on colonic health. The present study aimed at exploring the effect of niacin on experimental colitis as well as throwing some light on the ability of niacin to modulate angiogenesis which plays a crucial role of in the pathogenesis of inflammatory bowel disease. Rats were given niacin for 2 weeks. On day 8, colitis was induced by intrarectal administration of iodoacetamide. Rats were sacrificed on day 15 and colonic damage was assessed macroscopically and histologically...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28768650/intake-of-niacin-folate-vitamin-b-6-and-vitamin-b-12-through-young-adulthood-and-cognitive-function-in-midlife-the-coronary-artery-risk-development-in-young-adults-cardia-study
#15
Bo Qin, Pengcheng Xun, David R Jacobs, Na Zhu, Martha L Daviglus, Jared P Reis, Lyn M Steffen, Linda Van Horn, Stephen Sidney, Ka He
Background: Epidemiologic evidence regarding niacin, folate, vitamin B-6, and vitamin B-12 intake in relation to cognitive function is limited, especially in midlife.Objective: We hypothesize that higher intake of these B vitamins in young adulthood is associated with better cognition later in life.Design: This study comprised a community-based multicenter cohort of black and white men and women aged 18-30 y in 1985-1986 (year 0, i.e., baseline) from the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 3136)...
August 2, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28766583/niacin-associated-acute-hepatotoxicity-leading-to-emergency-liver-transplantation
#16
Silvia Schaffellner, Vanessa Stadlbauer, Michael Sereinigg, Helmut Mìller, Christoph Högenauer, Peter Fickert, Jakub Krumnikl, Carolin Lackner, Daniela Kniepeiss, Rudolf E Stauber
No abstract text is available yet for this article.
August 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28766509/high-density-lipoprotein-metabolism-and-reverse-cholesterol-transport-strategies-for-raising-hdl-cholesterol
#17
Katerina Tosheska Trajkovska, Sonja Topuzovska
A key to effective treatment of cardiovascular disease is to understand the body's complex lipoprotein transport system. Reverse cholesterol transport (RCT) is the process of cholesterol movement from the extrahepatic tissues back to the liver. Lipoproteins containing apoA-I [highdensity lipoprotein (HDL)] are key mediators in RCT, whereas non-high-density lipoproteins (non-HDL, lipoproteins containing apoB) are involved in the lipid delivery pathway. HDL particles are heterogeneous; they differ in proportion of proteins and lipids, size, shape, and charge...
August 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28763003/short-term-effects-of-a-ready-to-drink-pre-workout-beverage-on-exercise-performance-and-recovery
#18
Patrick B Collins, Conrad P Earnest, Ryan L Dalton, Ryan J Sowinski, Tyler J Grubic, Christopher J Favot, Adriana M Coletta, Christopher Rasmussen, Mike Greenwood, Richard B Kreider
In a double-blind, randomized and crossover manner, 25 resistance-trained participants ingested a placebo (PLA) beverage containing 12 g of dextrose and a beverage (RTD) containing caffeine (200 mg), β-alanine (2.1 g), arginine nitrate (1.3 g), niacin (65 mg), folic acid (325 mcg), and Vitamin B12 (45 mcg) for 7-days, separated by a 7-10-day. On day 1 and 6, participants donated a fasting blood sample and completed a side-effects questionnaire (SEQ), hemodynamic challenge test, 1-RM and muscular endurance tests (3 × 10 repetitions at 70% of 1-RM with the last set to failure on the bench press (BP) and leg press (LP)) followed by ingesting the assigned beverage...
August 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28762704/niacin-does-not-decrease-mortality-in-patients-with-coronary-artery-disease-or-low-hdl
#19
Allen F Shaughnessy
No abstract text is available yet for this article.
July 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28760418/energy-and-nutrient-intake-of-infants-and-young-children-in-pastoralist-communities-of-ethiopia
#20
Girma Mengistu, Tibebu Moges, Aregash Samuel, Kaleab Baye
OBJECTIVE: Nutrient intake from complementary foods often is suboptimal in subsistent farming households of developing countries, but little is known about this in pastoralist communities. The aim of this study was to estimate the energy and nutrient intake of children ages 6 to 23 mo living in pastoralist communities of Ethiopia. METHOD: As part of the Ethiopian National Food Consumption Survey, 24-h dietary recall data were collected through in-home interviews from a nationally representative sample...
September 2017: Nutrition
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