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renal disease diet

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https://www.readbyqxmd.com/read/29777021/serum-6-bromotryptophan-levels-identified-as-a-risk-factor-for-ckd-progression
#1
Adrienne Tin, Girish Nadkarni, Anne M Evans, Cheryl A Winkler, Erwin Bottinger, Casey M Rebholz, Mark J Sarnak, Lesley A Inker, Andrew S Levey, Michael S Lipkowitz, Lawrence J Appel, Dan E Arking, Josef Coresh, Morgan E Grams
Background Metabolite levels reflect physiologic homeostasis and may serve as biomarkers of disease progression. Identifying metabolites associated with APOL1 risk alleles-genetic variants associated with CKD risk commonly present in persons of African descent-may reveal novel markers of CKD progression relevant to other populations. Methods We evaluated associations between the number of APOL1 risk alleles and 760 serum metabolites identified via untargeted profiling in participants of the African American Study of Kidney Disease and Hypertension (AASK) ( n =588; Bonferroni significance threshold P <6...
May 18, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29772737/distal-colon-motor-dysfunction-in-mice-with-chronic-kidney-disease-putative-role-of-uremic-toxins
#2
Elsa Hoibian, Nans Florens, Laetitia Koppe, Hubert Vidal, Christophe O Soulage
Although gastrointestinal complications are a common feature of patients with chronic kidney disease (CKD), the impact of uremia on bowel motility remains poorly understood. The present study was, therefore, designed to investigate the impact of uremia on gut motility. Kidney failure was induced in mice by chemical nephrectomy using an adenine diet (0.25% w/w ). Gastrointestinal transit time and colon motility were explored in vivo and ex vivo . Colons from control mice were incubated with uremic plasma or uremic toxins (urea, indoxyl-sulfate or p-cresyl-sulfate) at concentrations encountered in patients with end-stage renal disease...
May 16, 2018: Toxins
https://www.readbyqxmd.com/read/29769033/case-report-on-pathogenetic-link-between-gluten-and-iga-nephropathy
#3
Stefano Costa, Giovanni Currò, Salvatore Pellegrino, Maria Cristina Lucanto, Giovanni Tuccari, Antonio Ieni, Giuseppina Visalli, Giuseppe Magazzù, Domenico Santoro
BACKGROUND: A relationship between IgA nephropathy (IgAN) and celiac disease (CD) has been reported. We show the pathogenetic link for the first time. CASE PRESENTATION: A 39-year-old man with cystic fibrosis (CF) and CF-related diabetes started to present gross hematuria, back pain and headache. At admission, laboratory analysis showed increase in serum creatinine of 1.5 mg/dl, together with hematuria and mild proteinuria (1 g/24 h). He underwent a renal biopsy to investigate the cause of hematuria and renal failure...
May 16, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29764624/hydrolyzed-proteins-from-herring-and-salmon-rest-raw-material-contain-peptide-motifs-with-angiotensin-i-converting-enzyme-inhibitors-and-resulted-in-lower-urine-concentrations-of-protein-cystatin-c-and-glucose-when-fed-to-obese-zucker-fa-fa-rats
#4
Aslaug Drotningsvik, Daniela Maria Pampanin, Rasa Slizyte, Ana Carvajal, Ingmar Høgøy, Tore Remman, Oddrun Anita Gudbrandsen
The use of angiotensin-I converting enzyme (ACE) inhibitors is a common strategy for treating kidney disease. Several amino acid sequences with ACE inhibiting activity are identified in filet and rest raw material from various species of fish, and fish protein hydrolysates could be of interest for possible treatment or prevention of kidney disease. Therefore, we hypothesized that protein hydrolysates from rest raw material from herring and salmon contained ACE inhibiting motifs, and could beneficially affect typical markers for kidney function in an obesity rat model prone to developing renal failure...
April 2018: Nutrition Research
https://www.readbyqxmd.com/read/29760664/reduced-renal-mass-salt-sensitive-hypertension-is-resistant-to-renal-denervation
#5
Ionut Tudorancea, Thomas E Lohmeier, Barbara T Alexander, Dragos Pieptu, Dragomir N Serban, Radu Iliescu
Aim: Activation of the sympathetic nervous system is common in resistant hypertension (RHT) and also in chronic kidney disease (CKD), a prevalent condition among resistant hypertensives. However, renal nerve ablation lowers blood pressure (BP) only in some patients with RHT. The influence of loss of nephrons per se on the antihypertensive response to renal denervation (RDNx) is unclear and was the focus of this study. Methods: Systemic hemodynamics and sympathetically mediated low frequency oscillations of systolic BP were determined continuously from telemetrically acquired BP recordings in rats before and after surgical excision of ∼80% of renal mass and subsequent RDNx...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29757885/maximizing-your-nutrition-minute-bridging-nutritional-gaps-across-the-life-span
#6
Wendy L Wright, Kathleen M Zelman
BACKGROUND AND PURPOSE: Poor diet quality has been associated with increased mortality and an increased risk of chronic disease. Given the shortfalls in the typical American diet and the prevalence of nutrition-related chronic disease among US adults, the need for nutrition education is paramount. Nurse practitioners (NPs) are well placed to provide basic nutrition counseling but often face challenges to making this a reality. In a typical office visit, the time available to discuss diet and nutrition can be as little as one minute or less...
March 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29756122/very-low-protein-diet-to-postpone-renal-failure-pathophysiology-and-clinical-applications-in-chronic-kidney-disease
#7
Vincenzo Bellizzi, Patrizia Calella, Juan Jesus Carrero, Denis Fouque
The uremic syndrome is a metabolic disorder characterized by the impairment of renal handling of several solutes, the resulting accumulation of toxic products and the activation of some adaptive but detrimental mechanisms which all together contribute to the progression of renal damage. In moderate to advanced renal failure, the dietary manipulation of nutrients improves metabolic abnormalities and may contribute to delay the time of dialysis initiation. This commentary focuses on the physiopathological rationale and the clinical application of the very low-protein diet supplemented with ketoanalogs for the management of chronic kidney disease...
March 2018: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29751994/dietary-potential-renal-acid-load-and-risk-of-albuminuria-and-reduced-kidney-function-in-the-jackson-heart-study
#8
Tanushree Banerjee, Katherine Tucker, Michael Griswold, Sharon B Wyatt, Jane Harman, Bessie Young, Herman Taylor, Neil R Powe
OBJECTIVE: Diets high in sulfur-rich protein and low in fruit and vegetables affect human acid-base balance adversely and may have a harmful effect on progression of chronic kidney disease (CKD). Little is known about the relationship of participant characteristics, dietary acid load (DAL), and kidney injury in African-Americans with high risk of CKD progression. DESIGN AND METHODS: We examined the association of DAL with CKD in 3,257 African-Americans aged >20 years in Jackson Heart Study...
May 8, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29743031/safety-and-effectiveness-of-low-protein-diet-supplemented-with-ketoacids-in-diabetic-patients-with-chronic-kidney-disease
#9
Vincenzo Bellizzi, Patrizia Calella, Julia Nava Hernández, Verónica Figueroa González, Silvia Moran Lira, Serena Torraca, Rocio Urbina Arronte, Pietro Cirillo, Roberto Minutolo, Rafael A Montúfar Cárdenas
BACKGROUND: The impact of the low-protein diet on nutrition in CKD diabetics is uncertain. METHODS: The metabolic and nutritional effects of a low-protein (0.5-0.6 g/kg/d), normal-high energy (30-35 kcal/kg/d) diet supplemented with ketoacids (LPD-KA) were prospectively evaluated in CKD patients with (DM) and without (non-DM) diabetes mellitus. RESULTS: 197 patients on CKD stages 3-5 were enrolled. DM (n = 81) and non-DM (n = 116) were comparable for gender (Male 58 vs 55%), age (66 ± 9 vs 63 ± 18 years), renal function (eGFR 23 ± 13 vs 24 ± 13 mL/min)...
May 9, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29740333/flavonoids-in-kidney-health-and-disease
#10
REVIEW
Félix Vargas, Paola Romecín, Ana I García-Guillén, Rosemary Wangesteen, Pablo Vargas-Tendero, M Dolores Paredes, Noemí M Atucha, Joaquín García-Estañ
This review summarizes the latest advances in knowledge on the effects of flavonoids on renal function in health and disease. Flavonoids have antihypertensive, antidiabetic, and antiinflammatory effects, among other therapeutic activities. Many of them also exert renoprotective actions that may be of interest in diseases such as glomerulonephritis, diabetic nephropathy, and chemically-induced kidney insufficiency. They affect several renal factors that promote diuresis and natriuresis, which may contribute to their well-known antihypertensive effect...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29738479/animal-and-plant-protein-intake-and-body-mass-index-and-waist-circumference-in-a-korean-elderly-population
#11
Ki-Byeong Park, Hyun Ah Park, Jae-Heon Kang, Kyoungwoo Kim, Young Gyu Cho, Jinyoung Jang
Controversy exists on whether animal and plant proteins influence obesity differently. The purpose of this study was to evaluate the association between total, animal, and plant protein intake with the body mass index (BMI), waist circumference (WC), and renal function in the Korean elderly. Study participants included Korean adults aged 60 years or older from the Korean National Health and Nutrition Examination Survey in 2013⁻2014. Height, weight, and waist circumference were measured and the body mass index was calculated...
May 8, 2018: Nutrients
https://www.readbyqxmd.com/read/29738375/magnesium-citrate-protects-against-vascular-calcification-in-an-adenine-induced-crf-rat-model
#12
PhD Zhihui-Yao, M D Yang-Xu, M D Weidong-Ma, Xin-Yuan Sun, PhD Shan-Jia, M D Yang-Zheng, M D Xiaohuan-Liu, M D Yajie-Fan, M D Congxia-Wang
BACKGROUND: Hypomagnemia was identified as a strong risk factor for cardiovascular disease in patients with chronic renal failure (CRF). However, the effects of magnesium (Mg) on vascular calcification (VC) have not been fully elucidated. Thus we aim to determine the effects of Mg citrate (MgCit) on VC in CRF rats. METHODS: Rats were divided into 5 groups: group 1 (normal diet); group 2 (normal diet with MgCit); group 3 (VC model of CRF induced by 0.75% adenine and 0...
April 24, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29736630/variations-in-clinical-management-of-non-vitamin-k-antagonist-oral-anticoagulants-in-patients-with-atrial-fibrillation-according-to-different-equations-for-estimating-renal-function-post-hoc-analysis-of-a-prospective-cohort
#13
Vincenzo Livio Malavasi, Daniele Pettorelli, Elisa Fantecchi, Cristina Zoccali, Giuliana Laronga, Tommaso Trenti, Gregory Yoke Hong Lip, Giuseppe Boriani
Prescription of non-vitamin K antagonist oral anticoagulants (NOACs) requires an assessment of renal function (RF) and the Cockcroft-Gault (CG) equation is traditionally recommended. The objective of the study was to evaluate the potential changes in NOACs management using different equations for estimating RF. In a post hoc analysis of a prospective cohort of patients with atrial fibrillation, we considered different equations: (1) CG for creatinine clearance (CrCl), (2) modification of diet in renal disease (MDRD), (3) CKD-EPI, (4) Berlin Initiative Study 1 (BIS-1) and (5) full age spectrum (FAS), for glomerular filtration rate (GFR)...
May 7, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29731059/long-term-follow-up-of-living-kidney-donors-with-chronic-kidney-disease-at-1-year-after-nephrectomy
#14
J C Na, J S Park, M-G Yoon, H H Lee, Y E Yoon, K H Huh, Y S Kim, W K Han
BACKGROUND: Although renal function recovery of living kidney donors has been reported in a number of studies, many patients show poor recovery, and the long-term prognosis of these patients has not been well studied. In this investigation we explored the long-term prognosis of renal function in patients with chronic kidney disease (CKD) at 1 year after nephrectomy. METHODS: Patients who underwent donor nephrectomy during the period from March 2006 to April 2014, with a follow-up creatinine study at 1 year postoperatively and more than 3 years of follow-up, were included in the study...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29730503/fibulin-7-a-heparin-binding-matricellular-protein-promotes-renal-tubular-calcification-in-mice
#15
Jun Tsunezumi, Hidekazu Sugiura, Lalhaba Oinam, Aktar Ali, Bui Quoc Thang, Aiko Sada, Yoshito Yamashiro, Makoto Kuro-O, Hiromi Yanagisawa
Ectopic calcification occurs during development of chronic kidney disease and has a negative impact on long-term prognosis. The precise molecular mechanism and prevention strategies, however, are not established. Fibulin-7 (Fbln7) is a matricellular protein structurally similar to elastogenic short fibulins, shown to bind dental mesenchymal cells and heparin. Here, we report that Fbln7 is highly expressed in renal tubular epithelium in the adult kidney and mediates renal calcification in mice. In vitro analysis revealed that Fbln7 bound heparin at the N-terminal coiled-coil domain...
May 3, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29728307/outcome-measures-used-to-report-kidney-function-in-studies-investigating-surgical-management-of-kidney-tumours-a-systematic-review
#16
REVIEW
Robert J Ellis, Yeoungjee Cho, Sharon J Del Vecchio, Megan McStea, Christudas Morais, Jeff S Coombes, Simon T Wood, Glenda C Gobe, Ross S Francis
CONTEXT: Most practice decisions relevant to preserving kidney function in patients managed surgically for kidney tumours are driven by observational studies. A wide range of outcome measures are used in these studies, which reduces comparability and increases the risk of reporting bias. OBJECTIVE: To comprehensively and succinctly describe the outcomes used to evaluate kidney function in studies evaluating surgical management of kidney tumours. EVIDENCE ACQUISITION: Electronic search of the PubMed database was conducted to identify studies with at least one measure of kidney function in patients managed surgically for kidney tumours, published between January 2000 and September 2017...
May 1, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29716795/metformin-prevents-the-development-of-severe-chronic-kidney-disease-and-its-associated-mineral-and-bone-disorder
#17
Ellen Neven, Benjamin Vervaet, Kerstin Brand, Ulrike Gottwald-Hostalek, Britt Opdebeeck, Annelies De Maré, Anja Verhulst, Jean-Daniel Lalau, Said Kamel, Marc E De Broe, Patrick C D'Haese
Chronic kidney disease (CKD) causes dysregulation of mineral metabolism, vascular calcification and renal osteodystrophy, an entity called 'CKD-Mineral and Bone Disorder' (CKD-MBD). Here we determine whether metformin, an anti-diabetic drug, exerts favorable effects on progressive, severe CKD and concomitant mineral metabolism disturbances. Rats with CKD-MBD, induced by a 0.25% adenine diet for eight weeks, were treated with 200 mg/kg/day metformin or vehicle from one week after CKD induction onward. Severe, stable CKD along with marked hyperphosphatemia and hypocalcemia developed in these rats which led to arterial calcification and high bone turnover disease...
April 28, 2018: Kidney International
https://www.readbyqxmd.com/read/29714040/mitoprotection-preserves-the-renal-vasculature-in-porcine-metabolic-syndrome
#18
Alfonso Eirin, Ahmad F Hedayat, Christopher M Ferguson, Stephen C Textor, Amir Lerman, Lilach O Lerman
NEW FINDINGS: What is the central question of this study? We hypothesized that chronic mitoprotection would decrease renal vascular remodeling and dysfunction in swine metabolic syndrome. What is the main finding and its importance? This study shows that experimental metabolic syndrome exerts renal microvascular and endothelial cell mitochondrial injury, which were attenuated by mitoprotection, underscoring the contribution of mitochondrial injury to the pathogenesis of metabolic syndrome-induced vascular damage...
April 30, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29707388/risk-factors-and-co-morbidities-associated-with-changes-in-renal-function-among-antiretroviral-treatment-na%C3%A3-ve-adults-in-south-africa-a-chart-review
#19
Shirelle Assaram, Tivani P Mashamba-Thompson, Nombulelo P Magula
Introduction: Our systematic scoping review has demonstrated a research gap in antiretroviral treatment (ART) nephrotoxicity as well as in the long-term outcomes of renal function for patients on ART in South Africa. Bearing in mind the high prevalence of human immunodeficiency virus (HIV) in South Africa, this is of great concern. Objectives: To determine the risk factors and co-morbidities associated with changes in renal function in HIV-infected adults in South Africa...
2018: Southern African Journal of HIV Medicine
https://www.readbyqxmd.com/read/29702558/a-low-protein-diet-for-diabetic-kidney-disease-its-effect-and-molecular-mechanism-an-approach-from-animal-studies
#20
REVIEW
Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koya
A low-protein diet (LPD) can be expected to retard renal function decline in advanced stages of chronic kidney disease (CKD), including diabetic kidney disease (DKD), and is recommended in a clinical setting. Regarding the molecular mechanisms of an LPD against DKD, previous animal studies have shown that an LPD exerts reno-protection through mainly the improvement of glomerular hyperfiltration/hypertension due to the reduction of intraglomerular pressure. On the other hand, we have demonstrated that an LPD, particularly a very-LPD (VLPD), improved tubulo-interstitial damage, inflammation and fibrosis, through the restoration of autophagy via the reduction of a mammalian target of rapamycin complex 1 (mTORC1) activity in type 2 diabetes and obesity animal models...
April 27, 2018: Nutrients
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