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https://www.readbyqxmd.com/read/27403879/selective-hair-cell-ablation-and-noise-exposure-lead-to-different-patterns-of-changes-in-the-cochlea-and-the-cochlear-nucleus
#1
Takaomi Kurioka, Min Young Lee, Amarins N Heeringa, Lisa A Beyer, Donald L Swiderski, Ariane C Kanicki, Lisa L Kabara, David F Dolan, Susan E Shore, Yehoash Raphael
In experimental animal models of auditory hair cell (HC) loss, insults such as noise or ototoxic drugs often lead to secondary changes or degeneration in non-sensory cells and neural components, including reduced density of spiral ganglion neurons, demyelination of auditory nerve fibers and altered cell numbers and innervation patterns in the cochlear nucleus (CN). However, it is not clear whether loss of HCs alone leads to secondary degeneration in these neural components of the auditory pathway. To elucidate this issue, we investigated changes of central components after cochlear insults specific to HCs using diphtheria toxin receptor (DTR) mice expressing DTR only in HCs and exhibiting complete HC loss when injected with diphtheria toxin (DT)...
September 22, 2016: Neuroscience
https://www.readbyqxmd.com/read/27351769/clinical-biopsychosocial-physiotherapy-assessment-of-patients-with-chronic-pain-the-first-step-in-pain-neuroscience-education
#2
Amarins J Wijma, C Paul van Wilgen, Mira Meeus, Jo Nijs
Pain neuroscience education (PNE) is increasingly used as part of a physical therapy treatment in patients with chronic pain. A thorough clinical biopsychosocial assessment is recommended prior to PNE to allow proper explanation of the neurophysiology of pain and the biopsychosocial interactions in an interactive and patient-centered manner. However, without clear guidelines, clinicians are left wondering how a biopsychosocial assessment should be administered. Therefore, we provided a practical guide, based on scientific research and clinical experience, for the biopsychosocial assessment of patients with chronic pain in physiotherapy practice...
July 2016: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/27142228/pain-following-cancer-treatment-guidelines-for-the-clinical-classification-of-predominant-neuropathic-nociceptive-and-central-sensitization-pain
#3
Jo Nijs, Laurence Leysen, Nele Adriaenssens, Maria Encarnación Aguilar Ferrándiz, Nele Devoogdt, An Tassenoy, Kelly Ickmans, Dorien Goubert, C Paul van Wilgen, Amarins J Wijma, Kevin Kuppens, Wouter Hoelen, Astrid Hoelen, Niamh Moloney, Mira Meeus
BACKGROUND: In addition to fatigue, pain is the most frequent persistent symptom in cancer survivors. Clear guidelines for both the diagnosis and treatment of pain in cancer survivors are lacking. Classification of pain is important as it may facilitate more specific targeting of treatment. In this paper we present an overview of nociceptive, neuropathic and central sensitization pain following cancer treatment, as well as the rationale, criteria and process for stratifying pain classification...
June 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27084416/after-amarin-v-fda-what-will-the-future-hold-for-off-label-promotion-regulation
#4
Tim K Mackey, Bryan A Liang
No abstract text is available yet for this article.
June 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27032824/amarin-agreement-opens-off-label-promotion-door
#5
Asher Mullard
No abstract text is available yet for this article.
April 1, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/26978686/an-uninformative-truth-the-logic-of-amarin-s-off-label-promotion
#6
Spencer Phillips Hey, Aaron S Kesselheim
Spencer Phillips Hey and Aaron Kesselheim propose that informativeness-asserting scientific facts-rather than truthfulness ought to be the standard for regulating commercial speech about pharmaceuticals.
March 2016: PLoS Medicine
https://www.readbyqxmd.com/read/26961922/smoking-cessation-support-among-oncology-practitioners-in-a-regional-cancer-center-in-the-middle-east-improving-a-critical-service-for-cancer-care
#7
Nour A Obeidat, Hiba S Ayub, Rula Amarin, Barakat Aburajab Altamimi, Iyad Ghonimat, Susan Abughosh, Feras I Hawari
No abstract text is available yet for this article.
April 2016: Oncologist
https://www.readbyqxmd.com/read/26955816/educational-needs-of-oncology-practitioners-in-a-regional-cancer-center-in-the-middle-east-improving-the-content-of-smoking-cessation-training-programs
#8
N A Obeidat, F I Hawari, R Amarin, B Aburajab Altamimi, I M Ghonimat
Little is known with regard to perceptions and information needs of oncology practitioners in the Middle East as they pertain to smoking cessation (SC) support for cancer patients. We sought to assess these in a regional cancer center. A survey was distributed to oncology practitioners (physicians, nurses, pharmacists, and physio- and respiratory therapists) at King Hussein Cancer Center (Amman, Jordan) for self-completion. The survey included SC-related measures of perceptions, knowledge, and practices. Descriptive statistics and cross tabulations were performed to identify misperceptions and knowledge gaps that could be corrected through continuing education...
March 8, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/26513338/sequencing-and-de-novo-draft-assemblies-of-a-fathead-minnow-pimephales-promelas-reference-genome
#9
Frank R Burns, Amarin L Cogburn, Gerald T Ankley, Daniel L Villeneuve, Eric Waits, Yun-Juan Chang, Victor Llaca, Stephane D Deschamps, Raymond E Jackson, Robert Alan Hoke
The present study was undertaken to provide the foundation for development of genome-scale resources for the fathead minnow (Pimephales promelas), an important model organism widely used in both aquatic toxicology research and regulatory testing. The authors report on the first sequencing and 2 draft assemblies for the reference genome of this species. Approximately 120× sequence coverage was achieved via Illumina sequencing of a combination of paired-end, mate-pair, and fosmid libraries. Evaluation and comparison of these assemblies demonstrate that they are of sufficient quality to be useful for genome-enabled studies, with 418 of 458 (91%) conserved eukaryotic genes mapping to at least 1 of the assemblies...
January 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/26333170/extensional-viscosity-of-copper-nanowire-suspensions-in-an-aqueous-polymer-solution
#10
Amarin G McDonnell, Naveen N Jason, Leslie Y Yeo, James R Friend, Wenlong Cheng, Ranganathan Prabhakar
Suspensions of copper nanowires are emerging as new electronic inks for next-generation flexible electronics. Using a novel surface acoustic wave driven extensional flow technique we are able to perform currently lacking analysis of these suspensions and their complex buffer. We observe extensional viscosities from 3 mPa s (1 mPa s shear viscosity) to 37.2 Pa s via changes in the suspension concentration, thus capturing low viscosities that have been historically very challenging to measure. These changes equate to an increase in the relative extensional viscosity of nearly 12,200 times at a volume fraction of just 0...
November 7, 2015: Soft Matter
https://www.readbyqxmd.com/read/26332553/forbidden-and-permitted-statements-about-medications-loosening-the-rules
#11
Jerry Avorn, Ameet Sarpatwari, Aaron S Kesselheim
In May 2015, Amarin, a small Irish pharmaceutical company, brought a preemptive suit against the Food and Drug Administration (FDA), arguing that if the agency were to refuse to allow it to distribute information about the usefulness of its product (a prescription fish oil) for an unapproved..
September 3, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26198162/pulmonary-embolism-diagnosed-from-right-heart-changes-seen-after-exercise-stress-echocardiography
#12
Brian C Case, Micheas Zemedkun, Amarin Sangkharat, Allen J Taylor, Monvadi B Srichai
No abstract text is available yet for this article.
August 2015: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/25969844/motility-induced-changes-in-viscosity-of-suspensions-of-swimming-microbes-in-extensional-flows
#13
Amarin G McDonnell, Tilvawala C Gopesh, Jennifer Lo, Moira O'Bryan, Leslie Y Yeo, James R Friend, Ranganathan Prabhakar
Suspensions of motile cells are model systems for understanding the unique mechanical properties of living materials which often consist of ensembles of self-propelled particles. We present here a quantitative comparison of theory against experiment for the rheology of such suspensions in extensional flows. The influence of motility on viscosities of cell suspensions is studied using a novel acoustically-driven microfluidic capillary-breakup extensional rheometer. Motility increases the extensional viscosity of suspensions of algal pullers, but decreases it in the case of bacterial or sperm pushers...
June 21, 2015: Soft Matter
https://www.readbyqxmd.com/read/25518169/prevalence-of-injuries-in-wushu-competition-during-the-1st-asian-martial-arts-games-2009
#14
Pichet Yiemsiri, Amarin Wanawan
OBJECTIVE: To determine the prevalence and characteristic of injuries in Wushu Competition during the IP' Asian MartialArts Games 2009. MATERIAL AND METHOD: Sixty international athletes (38 males) participating in Wushu Competition during the 1st Asian Martial Arts Games 2009. Injuries were recorded on injury report forms to document any injuries seen and treatment provided by tournament physician during competitions. The injury forms described the athlete s causes, type, site, and severity of the injuries...
February 2014: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/25360130/spontaneous-behavior-in-noise-and-silence-a-possible-new-measure-to-assess-tinnitus-in-guinea-pigs
#15
Amarins N Heeringa, Martijn J H Agterberg, Pim van Dijk
This study describes two experiments that were conducted in search for a behavioral paradigm to test for tinnitus in guinea pigs. Conditioning paradigms are available to determine the presence of tinnitus in animals and are based on the assumption that tinnitus impairs their ability to detect silent intervals in continuous noise. Guinea pigs have not been subjected to these paradigms yet; therefore, we investigated whether guinea pigs could be conditioned in the two-way shuttle-box paradigm to respond to silent intervals in noise...
2014: Frontiers in Neurology
https://www.readbyqxmd.com/read/25296654/efficacy-of-dehydroepiandrosterone-to-overcome-the-effect-of-ovarian-ageing-ditto-a-proof-of-principle-randomised-controlled-trial-protocol
#16
RANDOMIZED CONTROLLED TRIAL
Kannamannadiar Jayaprakasan, Amarin Narkwichean, Walid E Maalouf, Bruce K Campbell
INTRODUCTION: Dehydroepiandrosterone (DHEA) has been proposed to improve pregnancy rates in women with diminished ovarian reserve undergoing in vitro fertilisation (IVF) treatment. However, evidence regarding its efficacy is supported by a limited number of randomised controlled trials (RCTs). This double-blinded RCT aims to measure the effect of DHEA supplementation prior to and during controlled ovarian hyperstimulation on ovarian response prior to IVF treatment in women predicted to have poor ovarian reserve...
October 8, 2014: BMJ Open
https://www.readbyqxmd.com/read/25110876/hematopoietic-stem-cell-transplantation-of-an-adolescent-with-neurological-manifestations-of-homozygous-missense-prf1-mutation
#17
Ayad Ahmed Hussein, Tuka Hamadah, Monther Qandeel, Maher Sughayer, Rula Amarin, Asem Mansour, Samuel C Chiang, Abdulhadi Al-Zaben, Marie Meeths, Yenan T Bryceson
Individuals with biallelic truncating PRF1 mutations typically present with fulminant early-onset familial hemophagocytic lymphohistiocytosis (FHL). We report a 19-year-old male with a 5-year history of recurrent fever and headaches progressing to refractory seizures. Brain imaging revealed multiple ring enhancing lesions. Laboratory investigations demonstrated that the patient displayed defective lymphocyte cytotoxicity and carried a homozygous missense PRF1 mutation, c.394G > A (p.Gly132Arg). The patient was successfully treated with chemo-immunotherapy followed by matched related allogeneic hematopoietic stem cell transplantation (HSCT)...
December 2014: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/24592879/fallopian-tube-recanalisation-using-dedicated-radiographic-tubal-assessment-set-in-angiography-suite
#18
Mh Al-Omari, A Al-Mnayyis, N Obeidat, Z Amarin, F Zayed, L Rousan, H Al-Balas, K Alawneh, M El-Heis, Z Omari, R Hanania
INTRODUCTION: Fallopian tube recanalisation (FTR) for proximal fallopian tube obstruction (PFTO) is considered a good treatment option for tubal infertility. The aim of this study was to assess the safety and the technical and clinical success rates of FTR using a dedicated radiographic tubal assessment set (FluoroSet(®) ) in the angiography suite. METHODS: This study is a retrospective analysis of data prospectively collected between February 2007 and June 2011 at King Abdullah University Hospital, Irbid, Jordan...
August 2014: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/24428087/d-dimer-as-a-tumor-marker-in-pre-operative-assessment-of-adnexal-masses
#19
Pongkasem Worasethsin, Amarin Narkwichean
OBJECTIVE: To determine the sensitivity, specificity, and predictive value ofserum D-dimer testing in preoperative assessment of adnexal masses. MATERIAL AND METHOD: D-dimer levels were measured pre-operatively in 200 women diagnosed with adnexal masses who underwent surgical treatment at Department of Obstetrics and Gynecology, King Chulalongkorn Memorial Hospital between June 2007 and May 2008. The CA-125 level was also recorded RESULTS: When using cut-off value at 500 ng/ml, D-dimer has 91...
November 2013: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/23992623/birth-associated-long-bone-fractures
#20
Asma Basha, Zouhair Amarin, Freih Abu-Hassan
OBJECTIVE: To assess the incidence and outcome of neonatal long-bone fractures at a tertiary teaching hospital. METHODS: A retrospective study of all neonates with long-bone fractures delivered at Jordan University Hospital between January 1, 2000, and December 31, 2010. RESULTS: Among a total of 34 519 live births, 8 neonates had a long-bone fracture (incidence 0.23/1000 live births); of these, 6 had a femur fracture (0.17/1000 live births) and 2 had a humerus fracture (0...
November 2013: International Journal of Gynaecology and Obstetrics
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