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https://www.readbyqxmd.com/read/28934714/efficacy-of-dehydroepiandrosterone-dhea-to-overcome-the-effect-of-ovarian-ageing-ditto-a-proof-of-principle-double-blinded-randomized-placebo-controlled-trial
#1
Amarin Narkwichean, Walid Maalouf, Miriam Baumgarten, Lukasz Polanski, Nick Raine-Fenning, Bruce Campbell, Kannamannadiar Jayaprakasan
OBJECTIVE: To evaluate the effect of DHEA supplementation on In-Vitro Fertilisation (IVF) outcome as assessed by ovarian response, oocyte developmental competence and live birth rates in women predicted to have poor ovarian reserve (OR). The feasibility of conducting a large trial is also assessed by evaluating the recruitment rates and compliance of the recruited participants with DHEA/placebo intake and follow-up rates. STUDY DESIGN: A single centre, double blinded, placebo controlled, randomized trial was performed over two years with 60 women undergoing in-vitro fertilisation (IVF)...
September 8, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28820617/patient-centeredness-in-physiotherapy-what-does-it-entail-a-systematic-review-of-qualitative-studies
#2
Amarins J Wijma, Anouck N Bletterman, Jacqui R Clark, Sigrid C J M Vervoort, Anneke Beetsma, Doeke Keizer, Jo Nijs, C Paul Van Wilgen
PURPOSE: The literature review is aimed at examining and summarizing themes related to patient-centeredness identified in qualitative research from the perspectives of patients and physiotherapists. Following the review, a secondary aim was to synthesize the themes to construct a proposed conceptual framework for utilization within physiotherapy. METHODS: A systematic search of qualitative studies was conducted including all articles up to 2015 September. Methodological quality was examined with a checklist...
November 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28807856/low-levels-of-genetic-diversity-associated-with-evidence-of-negative-selection-on-the-babesia-bovis-apical-membrane-antigen-1-from-parasite-populations-in-thailand
#3
Amarin Rittipornlertrak, Boondarika Nambooppha, Pacharathon Simking, Veerasak Punyapornwithaya, Saruda Tiwananthagorn, Sathaporn Jittapalapong, Yang-Tsung Chung, Nattawooti Sthitmatee
Babesia bovis, a parasite infecting cattle and buffalo, continues to spread throughout the developing world. The babesial vaccine was developed to be a sustainable alternative treatment to control the parasite. However, genetic diversity is a major obstacle for designing and developing a safe and effective vaccine. The apical membrane antigen 1 (AMA-1) is considered to be a potential vaccine candidate antigen among immunogenic genes of B. bovis. To gain a more comprehensive understanding of B. bovis AMA-1 (BbAMA-1), three B...
August 12, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28752522/pentoxifylline-increases-the-level-of-nitric-oxide-produced-by-human-spermatozoa
#4
S A Banihani, R F Abu-Alhayjaa, Z O Amarin, K H Alzoubi
Pentoxifylline (PF) is a xanthine derivative drug primarily used to treat peripheral vascular disorders. It is currently used in assisted reproductive technologies to enhance human sperm motility. However, the mechanism by which this enhancement occurs is not fully understood. Given that nitric oxide has been identified as a trigger to sperm motion, we asked whether nitric oxide modulates the stimulatory effect of PF on sperm motility. A total of 41 semen samples from infertile males were studied. Nitric oxide production in the presence of 5 mm PF was tested using different bio-analytical methods (spectrophotometry, fluorometry and fluorescence microscopy)...
July 28, 2017: Andrologia
https://www.readbyqxmd.com/read/28713613/the-use-of-human-mature-cystic-ovarian-teratoma-as-a-model-to-study-the-development-of-human-lymphatics
#5
Rashid Al-Jomard, Zouhair Amarin
The angiogenic theory to the development of human lymphatics is not clear. The objective of this study was to investigate the development of human lymphatics. Semi-thin and thin paraffin sections from human mature cystic ovarian teratoma tissues were studied using light and electron microscopy. Lymphatics were formed by the differentiation of mesenchymal cells that gradually acquired morphological features of endothelial cells. It is suggested that in human mature cystic ovarian teratoma the lymphatic endothelium develops from mesenchymal cells, and not from cells derived from mature endothelium of a preexisting vein or lymphatic...
June 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/28621106/a-rapid-and-efficient-screening-method-for-antibacterial-compound-producing-bacteria
#6
Sachithra Hettiarachchi, Su-Jin Lee, Youngdeuk Lee, Young-Kyung Kwon, Mahanama De Zoysa, Song Moon, Eunyoung Jo, Taeho Kim, Do-Hyung Kang, Soo-Jin Heo, Chulhong Oh
Antibacterial compounds are widely used in the treatment of human and animal diseases. The overuse of antibiotics has led to a rapid rise in the prevalence of drug-resistant bacteria, making the development of new antibacterial compounds essential. This study focused on developing a fast and easy method for identifying marine bacteria that produce antibiotic compounds. Eight randomly selected marine target bacterial species (Agrococcus terreus, Bacillus algicola, Mesoflavibacter zeaxanthinifaciens, Pseudoalteromonas flavipulchra, P...
August 28, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28524700/what-is-important-in-transdisciplinary-pain-neuroscience-education-a-qualitative-study
#7
Amarins J Wijma, Caroline M Speksnijder, Astrid F Crom-Ottens, J M Corine Knulst-Verlaan, Doeke Keizer, Jo Nijs, C Paul van Wilgen
PURPOSE: The main focus of Pain Neuroscience Education is around changing patients' pain perceptions and minimizing further medical care. Even though Pain Neuroscience Education has been studied extensively, the experiences of patients regarding the Pain Neuroscience Education process remain to be explored. Therefore, the aim of this study was to explore the experiences in patients with non-specific chronic pain. MATERIALS AND METHODS: Fifteen patients with non-specific chronic pain from a transdisciplinary treatment centre were in-depth interviewed...
May 19, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28441203/the-pervasive-culture-of-abuse-in-medical-education-a-focus-on-developing-countries
#8
Justin Z Amarin, Saif M Borgan
No abstract text is available yet for this article.
May 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28417223/dorsal-metacarpal-veins-anatomic-variation-and-potential-clinical-implications
#9
Sara S Elmegarhi, Justin Z Amarin, Maher T Hadidi, Darwish H Badran, Islam M Massad, Amjad M Bani-Hani, Amjad T Shatarat
The dorsal metacarpal veins are frequently cannulated. Cannulation success is determined by several variable anatomic features. The objective of this study is to classify, for the first time, the anatomic variants of the dorsal metacarpal veins. In this cross-sectional study, 520 university students and staff were conveniently recruited. The dorsal metacarpal veins in 1040 hands were studied. Venous visibility was enhanced by either tourniquet application or near-infrared illumination. Variant patterns of the dorsal metacarpal veins were classified...
April 17, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/28339336/response-to-letter
#10
Amarins J Wijma, C Paul van Wilgen, Mira Meeus, Jo Nijs
No abstract text is available yet for this article.
March 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28339330/-clinical-biopsychosocial-physiotherapy-assessment-of-patients-with-chronic-pain-the-first-step-in-pain-neuroscience-education-by-amarins-j-wijma-et-al-2016
#11
Rob A B Oostendorp, Hans Elvers, Emilia Mikolajewska, Marjan Laekeman, Emiel van Trijffel, Han Samwel
No abstract text is available yet for this article.
March 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28099752/association-between-timing-of-elective-cesarean-delivery-and-adverse-outcomes-among-women-with-at-least-two-previous-cesareans
#12
COMPARATIVE STUDY
Jehan Hamadneh, Haifaa Alchalabi, Shereen Hamadneh, Zouhair Amarin, Yousef S Khader, Manal Kassab, Mahmoud Bani-Hani
OBJECTIVE: To assess the impact of delivery at 37 weeks of pregnancy versus 38 weeks or later on maternal and neonatal outcomes among women with multiple previous cesareans. METHODS: In a retrospective study, data were assessed from women with at least two previous cesareans who delivered by cesarean at 37 weeks of pregnancy or later at a tertiary referral hospital in Jordan between January 2013 and November 2015. RESULTS: Among 886 eligible women, 505 (57...
April 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28009529/high-prevalence-of-middle-east-respiratory-coronavirus-in-young-dromedary-camels-in-jordan
#13
Neeltje van Doremalen, Zaidoun S K Hijazeen, Peter Holloway, Bilal Al Omari, Chester McDowell, Danielle Adney, Hani A Talafha, Javier Guitian, John Steel, Nadim Amarin, Markos Tibbo, Ehab Abu-Basha, Ahmad M Al-Majali, Vincent J Munster, Juergen A Richt
Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) was determined in 45 dromedary camels from two geographically separated herds in Jordan. Virus shedding was only detected in swabs obtained from the respiratory tract and primarily observed in camels younger than 3 years. MERS-CoV seroprevalence increased with age of camels. Bovine and sheep sera were seronegative. Phylogenetic analysis of partial S2 clustered the Jordanian MERS-CoV strains with contemporary MERS-CoV strains associated with nosocomial outbreaks...
February 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/27403879/selective-hair-cell-ablation-and-noise-exposure-lead-to-different-patterns-of-changes-in-the-cochlea-and-the-cochlear-nucleus
#14
COMPARATIVE STUDY
Takaomi Kurioka, Min Young Lee, Amarins N Heeringa, Lisa A Beyer, Donald L Swiderski, Ariane C Kanicki, Lisa L Kabara, David F Dolan, Susan E Shore, Yehoash Raphael
In experimental animal models of auditory hair cell (HC) loss, insults such as noise or ototoxic drugs often lead to secondary changes or degeneration in non-sensory cells and neural components, including reduced density of spiral ganglion neurons, demyelination of auditory nerve fibers and altered cell numbers and innervation patterns in the cochlear nucleus (CN). However, it is not clear whether loss of HCs alone leads to secondary degeneration in these neural components of the auditory pathway. To elucidate this issue, we investigated changes of central components after cochlear insults specific to HCs using diphtheria toxin receptor (DTR) mice expressing DTR only in HCs and exhibiting complete HC loss when injected with diphtheria toxin (DT)...
September 22, 2016: Neuroscience
https://www.readbyqxmd.com/read/27351769/clinical-biopsychosocial-physiotherapy-assessment-of-patients-with-chronic-pain-the-first-step-in-pain-neuroscience-education
#15
REVIEW
Amarins J Wijma, C Paul van Wilgen, Mira Meeus, Jo Nijs
Pain neuroscience education (PNE) is increasingly used as part of a physical therapy treatment in patients with chronic pain. A thorough clinical biopsychosocial assessment is recommended prior to PNE to allow proper explanation of the neurophysiology of pain and the biopsychosocial interactions in an interactive and patient-centered manner. However, without clear guidelines, clinicians are left wondering how a biopsychosocial assessment should be administered. Therefore, we provided a practical guide, based on scientific research and clinical experience, for the biopsychosocial assessment of patients with chronic pain in physiotherapy practice...
July 2016: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/27142228/pain-following-cancer-treatment-guidelines-for-the-clinical-classification-of-predominant-neuropathic-nociceptive-and-central-sensitization-pain
#16
Jo Nijs, Laurence Leysen, Nele Adriaenssens, Maria Encarnación Aguilar Ferrándiz, Nele Devoogdt, An Tassenoy, Kelly Ickmans, Dorien Goubert, C Paul van Wilgen, Amarins J Wijma, Kevin Kuppens, Wouter Hoelen, Astrid Hoelen, Niamh Moloney, Mira Meeus
BACKGROUND: In addition to fatigue, pain is the most frequent persistent symptom in cancer survivors. Clear guidelines for both the diagnosis and treatment of pain in cancer survivors are lacking. Classification of pain is important as it may facilitate more specific targeting of treatment. In this paper we present an overview of nociceptive, neuropathic and central sensitization pain following cancer treatment, as well as the rationale, criteria and process for stratifying pain classification...
June 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27084416/after-amarin-v-fda-what-will-the-future-hold-for-off-label-promotion-regulation
#17
Tim K Mackey, Bryan A Liang
No abstract text is available yet for this article.
June 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27032824/amarin-agreement-opens-off-label-promotion-door
#18
Asher Mullard
No abstract text is available yet for this article.
April 1, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/26978686/an-uninformative-truth-the-logic-of-amarin-s-off-label-promotion
#19
Spencer Phillips Hey, Aaron S Kesselheim
Spencer Phillips Hey and Aaron Kesselheim propose that informativeness-asserting scientific facts-rather than truthfulness ought to be the standard for regulating commercial speech about pharmaceuticals.
March 2016: PLoS Medicine
https://www.readbyqxmd.com/read/26961922/smoking-cessation-support-among-oncology-practitioners-in-a-regional-cancer-center-in-the-middle-east-improving-a-critical-service-for-cancer-care
#20
Nour A Obeidat, Hiba S Ayub, Rula Amarin, Barakat Aburajab Altamimi, Iyad Ghonimat, Susan Abughosh, Feras I Hawari
No abstract text is available yet for this article.
April 2016: Oncologist
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